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Conserved domains on  [gi|515743253|ref|WP_017175853|]
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MULTISPECIES: Na+/H+ antiporter subunit E [Staphylococcus]

Protein Classification

Na+/H+ antiporter subunit E( domain architecture ID 10014032)

Na+/H+ antiporter subunit E is part of a Na+/H+ prokaryotic antiporter complex consists of seven subunits (MrpABCDEFG), which are involved in Na+ excretion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12651 PRK12651
Na+/H+ antiporter subunit E;
1-158 4.51e-71

Na+/H+ antiporter subunit E;


:

Pssm-ID: 237159  Cd Length: 158  Bit Score: 210.86  E-value: 4.51e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   1 MALQFVLNIILAIIWMFLSGSYTFNNFLLGFLIGIGLVYLFKKVLPGSFYLKRVYKVIKLIVVFFIELMKANIDVSKIVL 80
Cdd:PRK12651   1 MAFQLLLNIILAVLWLFLTGSFSLGNFIIGFILGLFVLFLFRRLLPARFYLRRIYKLIKLVPIFLKELIKANIDVAKIVL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515743253  81 QPRLKNQPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEIESIKSSLEKVVREVGE 158
Cdd:PRK12651  81 KPKLNIEPGIVAVPTDLKTDWEITLLANLITLTPGTLTLDVSDDRKKLYIHAIDVKDKEEEIREIKDSFEKILLEVFE 158
 
Name Accession Description Interval E-value
PRK12651 PRK12651
Na+/H+ antiporter subunit E;
1-158 4.51e-71

Na+/H+ antiporter subunit E;


Pssm-ID: 237159  Cd Length: 158  Bit Score: 210.86  E-value: 4.51e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   1 MALQFVLNIILAIIWMFLSGSYTFNNFLLGFLIGIGLVYLFKKVLPGSFYLKRVYKVIKLIVVFFIELMKANIDVSKIVL 80
Cdd:PRK12651   1 MAFQLLLNIILAVLWLFLTGSFSLGNFIIGFILGLFVLFLFRRLLPARFYLRRIYKLIKLVPIFLKELIKANIDVAKIVL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515743253  81 QPRLKNQPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEIESIKSSLEKVVREVGE 158
Cdd:PRK12651  81 KPKLNIEPGIVAVPTDLKTDWEITLLANLITLTPGTLTLDVSDDRKKLYIHAIDVKDKEEEIREIKDSFEKILLEVFE 158
2a6301s05 TIGR00942
Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding ...
 15-158 1.71e-54

Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130017  Cd Length: 144  Bit Score: 168.48  E-value: 1.71e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   15 WMFLSGSYTFNNFLLGFLIGIGLVYLFKKVLPGSFYLKRVYKVIKLIVVFFIELMKANIDVSKIVLQPRLKNQPGFFIYH 94
Cdd:TIGR00942   1 WLFVTQSVTPGSIVLGLIFSTVLAWVTLNLQPARSRLHRWSRIIGFILRFLGDVIKANIDVTLIILRPRRPVNPGFMTVS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515743253   95 TDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEIESIKSSLEKVVREVGE 158
Cdd:TIGR00942  81 TDLKDENALALLANVITLTPGTAWLEYDRDRKIILFHVLDISNEELWRETITRSYEKDLKEIFE 144
MnhE COG1863
Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];
4-158 2.74e-54

Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441468  Cd Length: 162  Bit Score: 168.42  E-value: 2.74e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   4 QFVLNIILAIIWMFLSGSYTFNNFLLGFLIGIGLVYLFKKVLPGS-FYLKRVYKVIKLIVVFFIELMKANIDVSKIVLQP 82
Cdd:COG1863    7 HLLLSLLLALVWLLLSGSFSPGNLLLGLLLALLVLLLFRRLPPPRlPYLRRPLRLLRLLLYFLWDIVVANIDVARRVLRP 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515743253  83 RLKNQPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEIESIKSSLEKVVREVGE 158
Cdd:COG1863   87 RLPIRPGIVAVPLRLRSDLGITLLANSITLTPGTLTVDVDDDRRTLYVHALDVDDPEALIEEIKGRYERRLLEIFE 162
MNHE pfam01899
Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.
 8-156 6.14e-52

Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.


Pssm-ID: 460378  Cd Length: 150  Bit Score: 162.25  E-value: 6.14e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253    8 NIILAIIWMFLSGSYTFNNFLLGFLIGIGLVYLFKKVLPGSFYLKRVYK-VIKLIVVFFIELMKANIDVSKIVLQPRLKN 86
Cdd:pfam01899   1 NLLLAVVWLLLTGSFSPGNLLLGLLLGLLVLLLLRRLLPPRPPPRRPPLgLLRLLLYFLWEIVKANIQVARLVLRPKPPI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   87 QPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEIESIKSSLEKVVREV 156
Cdd:pfam01899  81 RPGIVAVPLRLRSDLALTLLANSITLTPGTLVVDVDRDRRVLYVHVLDVDDEEAARREIKGRLERRLLEI 150
 
Name Accession Description Interval E-value
PRK12651 PRK12651
Na+/H+ antiporter subunit E;
1-158 4.51e-71

Na+/H+ antiporter subunit E;


Pssm-ID: 237159  Cd Length: 158  Bit Score: 210.86  E-value: 4.51e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   1 MALQFVLNIILAIIWMFLSGSYTFNNFLLGFLIGIGLVYLFKKVLPGSFYLKRVYKVIKLIVVFFIELMKANIDVSKIVL 80
Cdd:PRK12651   1 MAFQLLLNIILAVLWLFLTGSFSLGNFIIGFILGLFVLFLFRRLLPARFYLRRIYKLIKLVPIFLKELIKANIDVAKIVL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515743253  81 QPRLKNQPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEIESIKSSLEKVVREVGE 158
Cdd:PRK12651  81 KPKLNIEPGIVAVPTDLKTDWEITLLANLITLTPGTLTLDVSDDRKKLYIHAIDVKDKEEEIREIKDSFEKILLEVFE 158
2a6301s05 TIGR00942
Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding ...
 15-158 1.71e-54

Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130017  Cd Length: 144  Bit Score: 168.48  E-value: 1.71e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   15 WMFLSGSYTFNNFLLGFLIGIGLVYLFKKVLPGSFYLKRVYKVIKLIVVFFIELMKANIDVSKIVLQPRLKNQPGFFIYH 94
Cdd:TIGR00942   1 WLFVTQSVTPGSIVLGLIFSTVLAWVTLNLQPARSRLHRWSRIIGFILRFLGDVIKANIDVTLIILRPRRPVNPGFMTVS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515743253   95 TDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEIESIKSSLEKVVREVGE 158
Cdd:TIGR00942  81 TDLKDENALALLANVITLTPGTAWLEYDRDRKIILFHVLDISNEELWRETITRSYEKDLKEIFE 144
MnhE COG1863
Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];
4-158 2.74e-54

Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441468  Cd Length: 162  Bit Score: 168.42  E-value: 2.74e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   4 QFVLNIILAIIWMFLSGSYTFNNFLLGFLIGIGLVYLFKKVLPGS-FYLKRVYKVIKLIVVFFIELMKANIDVSKIVLQP 82
Cdd:COG1863    7 HLLLSLLLALVWLLLSGSFSPGNLLLGLLLALLVLLLFRRLPPPRlPYLRRPLRLLRLLLYFLWDIVVANIDVARRVLRP 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515743253  83 RLKNQPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEIESIKSSLEKVVREVGE 158
Cdd:COG1863   87 RLPIRPGIVAVPLRLRSDLGITLLANSITLTPGTLTVDVDDDRRTLYVHALDVDDPEALIEEIKGRYERRLLEIFE 162
MNHE pfam01899
Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.
 8-156 6.14e-52

Na+/H+ ion antiporter subunit; Subunit of a Na+/H+ Prokaryotic antiporter complex.


Pssm-ID: 460378  Cd Length: 150  Bit Score: 162.25  E-value: 6.14e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253    8 NIILAIIWMFLSGSYTFNNFLLGFLIGIGLVYLFKKVLPGSFYLKRVYK-VIKLIVVFFIELMKANIDVSKIVLQPRLKN 86
Cdd:pfam01899   1 NLLLAVVWLLLTGSFSPGNLLLGLLLGLLVLLLLRRLLPPRPPPRRPPLgLLRLLLYFLWEIVKANIQVARLVLRPKPPI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   87 QPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEIESIKSSLEKVVREV 156
Cdd:pfam01899  81 RPGIVAVPLRLRSDLALTLLANSITLTPGTLVVDVDRDRRVLYVHVLDVDDEEAARREIKGRLERRLLEI 150
PRK08965 PRK08965
putative monovalent cation/H+ antiporter subunit E; Reviewed
 1-156 2.82e-49

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 181598  Cd Length: 162  Bit Score: 155.71  E-value: 2.82e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   1 MALQFVLNIILAIIWMFLSGSYTFNNFLLGFLIGIGLVYLFKKVLPGSFYLKRVYKVIKLIVVFFIELMKANIDVSKIVL 80
Cdd:PRK08965   5 LLPQPLLSLWLALVWLLLNGSFSLGNLLLGLLLGLLIPLLLALLVPLEGRLRRPLALLRLLLVVLYDLVVSNIQVAWLIL 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515743253  81 QPRLKNQPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEIESIKSSLEKVVREV 156
Cdd:PRK08965  85 RPGPRPRPGFVAVPLRLRSDLALTLLANIITLTPGTVVVEISRDRRTLYVHVLDLDDPEALIREIKQRYERLLMEI 160
PRK08383 PRK08383
putative monovalent cation/H+ antiporter subunit E; Reviewed
 63-158 1.90e-15

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 181407  Cd Length: 168  Bit Score: 69.45  E-value: 1.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253  63 VFFIELMKANIDVSKIVLQPRLKnqPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEI 142
Cdd:PRK08383  72 PLFWGMVKANLDVAYRVITGKIR--PGIVKVPVDLENDAQYTILSNSITLTPGTLTIEACPEEKALYVHWINVPEGLEKP 149

                         90
                 ....*....|....*....
gi 515743253 143 ES---IKSSLEKVVREVGE 158
Cdd:PRK08383 150 ESsepVSGPFEKWARRLGE 168
PRK12596 PRK12596
putative monovalent cation/H+ antiporter subunit E; Reviewed
 6-156 2.26e-15

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 105779  Cd Length: 171  Bit Score: 69.23  E-value: 2.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   6 VLNIILAIIWMFLSGsYTFNNFLLGFLIGIGLVYLFKKVLPGSFYLKRVYKVIKLIVVFFIELMKANIDVSKIVLQPRLK 85
Cdd:PRK12596   9 LLFVSLVLFWLLLNS-FTRAQFILGLVIAFGACRVMMALEPQKNHIRSPRMMIWLLYAASIDVLRSNIAVVRLILSPGRQ 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515743253  86 NQPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHSIDFSTKEEEIESIKSSLEKVVREV 156
Cdd:PRK12596  88 RHPGFVVIPLELQNRTALAVLACMITASPGTAWVDYNAARGILTIHVLDLEDAETWRHLIKERYERPLIEI 158
PRK12652 PRK12652
monovalent cation/H+ antiporter subunit E;
67-156 5.09e-10

monovalent cation/H+ antiporter subunit E;


Pssm-ID: 237160 [Multi-domain]  Cd Length: 357  Bit Score: 56.68  E-value: 5.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253  67 ELMKANIDVSKIVLQPRLKNQPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRtkIYIHSIDFSTKEEEIEsik 146
Cdd:PRK12652 237 EIVKANVAIAYVILHPSLPIDPTMVRVRAAVRSGLPLTTLANSITLTPGTLTVDVDDRH--LLVHSLTPSAREDLFD--- 311

                         90
                 ....*....|
gi 515743253 147 SSLEKVVREV 156
Cdd:PRK12652 312 GGLERAVRFV 321
PRK08382 PRK08382
putative monovalent cation/H+ antiporter subunit E; Reviewed
 4-156 1.61e-09

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 169415  Cd Length: 201  Bit Score: 54.02  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253   4 QFVLN-IILAIIWMFLSGSYTFNNFLLGFLIGIGLVYLF-----------KKVLPGSFYLKRVYKVIKLIVVFFiELMKA 71
Cdd:PRK08382  34 RFVLTwLILLAFWVIISGDLSPRGLILGALTTLIIASYMrdfltedirrsGHLLWKILYFALIYLPQYLIIMAF-RLLES 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253  72 NIDVSKIVLqpRLKNQPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISD--DRTKIYIHSIDFST--KEEEIESIKS 147
Cdd:PRK08382 113 NLKVAKHVI--FMDINPGIVKIKTDLHSDTGITILANSITLTPGTLTLDVVKklGETYLYVHWIDVETlnREKAGEKIKG 190


                 ....*....
gi 515743253 148 SLEKVVREV 156
Cdd:PRK08382 191 DIEEWLKKI 199
PRK06279 PRK06279
putative monovalent cation/H+ antiporter subunit E; Reviewed
 53-142 3.24e-06

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 180506 [Multi-domain]  Cd Length: 100  Bit Score: 43.50  E-value: 3.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253  53 RVYKVIKLIVVFFIELMKANIDVSKIVLQPRLKnqPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDDRTKIYIHS 132
Cdd:PRK06279   2 RLLYGIGYLIVLIKAIIEAWIDVVKRSLNGKID--PEVIEIETEINRPVGQVLLANSITLTPGTLTIDLDSEERILKVAS 79

                         90
                 ....*....|
gi 515743253 133 IDFSTKEEEI 142
Cdd:PRK06279  80 ISPRSRDDII 89
PRK12654 PRK12654
monovalent cation/H+ antiporter subunit E;
100-126 2.16e-03

monovalent cation/H+ antiporter subunit E;


Pssm-ID: 237161  Cd Length: 151  Bit Score: 36.43  E-value: 2.16e-03
                         10        20
                 ....*....|....*....|....*..
gi 515743253 100 DWQIVLLSNLITLTPGTVVLGISDDRT 126
Cdd:PRK12654  47 DWQITALAASITATPGTLSLGLREPRK 73
PRK06580 PRK06580
putative monovalent cation/H+ antiporter subunit E; Reviewed
 58-124 8.08e-03

putative monovalent cation/H+ antiporter subunit E; Reviewed


Pssm-ID: 180628  Cd Length: 103  Bit Score: 34.07  E-value: 8.08e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743253  58 IKLIVVF---FIELMKANIDVSKIVLQPRLKNQPGFFIYHTDLKHDWQIVLLSNLITLTPGTVVLGISDD 124
Cdd:PRK06580   7 IKFILYFpwlLLEIWKSAFSVIKIIWQRKIGIEPVFEWVDAEGLEEIGEIIYGNSITLTPGTVTLDINNN 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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