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Conserved domains on  [gi|515743413|ref|WP_017176013|]
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MULTISPECIES: glycosyltransferase family 2 protein [Staphylococcus]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 11421525)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  16037492|18518825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-210 2.84e-33

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 122.50  E-value: 2.84e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   1 MKLAVIIPVYNAENTIRKAVKSID--TTHDVEIICINDGSTDRTKQVLTELQKEVKHLIVY-HQDNQGAAKSRNMGLSAM 77
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLaqTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIrLERNRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413  78 SDDIdaFMFLDADDQFLPGKMDQMIQYYEKNEHlDIVIGqigrglngdWKVIPTHEDIHREAIVSLAEAPEILQSI---G 154
Cdd:COG0463   82 RGDY--IAFLDADDQLDPEKLEELVAALEEGPA-DLVYG---------SRLIREGESDLRRLGSRLFNLVRLLTNLpdsT 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 515743413 155 PGGKLFKAK-FNTLRFDEDvvFCEEHTFVtRAYLMARDIQLVPFIvygYNEREGSIT 210
Cdd:COG0463  150 SGFRLFRREvLEELGFDEG--FLEDTELL-RALRHGFRIAEVPVR---YRAGESKLN 200
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-210 2.84e-33

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 122.50  E-value: 2.84e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   1 MKLAVIIPVYNAENTIRKAVKSID--TTHDVEIICINDGSTDRTKQVLTELQKEVKHLIVY-HQDNQGAAKSRNMGLSAM 77
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLaqTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIrLERNRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413  78 SDDIdaFMFLDADDQFLPGKMDQMIQYYEKNEHlDIVIGqigrglngdWKVIPTHEDIHREAIVSLAEAPEILQSI---G 154
Cdd:COG0463   82 RGDY--IAFLDADDQLDPEKLEELVAALEEGPA-DLVYG---------SRLIREGESDLRRLGSRLFNLVRLLTNLpdsT 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 515743413 155 PGGKLFKAK-FNTLRFDEDvvFCEEHTFVtRAYLMARDIQLVPFIvygYNEREGSIT 210
Cdd:COG0463  150 SGFRLFRREvLEELGFDEG--FLEDTELL-RALRHGFRIAEVPVR---YRAGESKLN 200
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 5-140 6.71e-28

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 107.10  E-value: 6.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413    5 VIIPVYNAENTIRKAVKSI-DTTH-DVEIICINDGSTDRTKQVLTELQKEVKHLIVYHQD-NQGAAKSRNMGLSAMSDDI 81
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLlNQTYpNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPeNRGKAGARNAGLRAATGDY 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 515743413   82 daFMFLDADDQFLPGKMDQMIQYYEKNEHlDIVIGQIGRGlNGDWKVIPTHEDIHREAI 140
Cdd:pfam00535  82 --IAFLDADDEVPPDWLEKLVEALEEDGA-DVVVGSRYVI-FGETGEYRRASRITLSRL 136
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-117 5.62e-26

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 101.43  E-value: 5.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSI--DTTHDVEIICINDGSTDRTKQVLTELQKEVKHLIVY-HQDNQGAAKSRNMGLSAMSDDI 81
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLlaQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRViNEENQGLAAARNAGLKAARGEY 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 515743413  82 daFMFLDADDQFLPGKMDQMIQYYEKNEHLDIVIGQ 117
Cdd:cd00761   81 --ILFLDADDLLLPDWLERLVAELLADPEADAVGGP 114
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 2-126 3.89e-19

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 86.64  E-value: 3.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   2 KLAVIIPVYNAENTIRKAVKSI--DTTHDVEIICINDGSTDRTKQVLTELQKEVKHLIVYHQDNQGAAKSRNMGLSAMSD 79
Cdd:PRK10073   7 KLSIIIPLYNAGKDFRAFMESLiaQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQANAGVSVARNTGLAVATG 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 515743413  80 DIDAFMflDADDQFLPGKMDQMIQYYEKNeHLDIVIGqigrglNGDW 126
Cdd:PRK10073  87 KYVAFP--DADDVVYPTMYETLMTMALED-DLDVAQC------NADW 124
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
1-91 7.42e-05

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 44.01  E-value: 7.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   1 MKLAVIIPVYNAENTIRK---AVKSIDTTHDV--EIICINDGSTDRTKQVLTELQKEVKH---LIVYHQDNQGAAKSRNM 72
Cdd:NF038302   1 LDFTVAIPTYNGANRLPEvleRLRSQIGTESLswEIIVVDNNSTDNTAQVVQEYQKNWPSpypLRYCFEPQQGAAFARQR 80

                         90       100
                 ....*....|....*....|
gi 515743413  73 GLS-AMSDDIDafmFLDaDD 91
Cdd:NF038302  81 AIQeAKGELIG---FLD-DD 96
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-210 2.84e-33

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 122.50  E-value: 2.84e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   1 MKLAVIIPVYNAENTIRKAVKSID--TTHDVEIICINDGSTDRTKQVLTELQKEVKHLIVY-HQDNQGAAKSRNMGLSAM 77
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLaqTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIrLERNRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413  78 SDDIdaFMFLDADDQFLPGKMDQMIQYYEKNEHlDIVIGqigrglngdWKVIPTHEDIHREAIVSLAEAPEILQSI---G 154
Cdd:COG0463   82 RGDY--IAFLDADDQLDPEKLEELVAALEEGPA-DLVYG---------SRLIREGESDLRRLGSRLFNLVRLLTNLpdsT 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 515743413 155 PGGKLFKAK-FNTLRFDEDvvFCEEHTFVtRAYLMARDIQLVPFIvygYNEREGSIT 210
Cdd:COG0463  150 SGFRLFRREvLEELGFDEG--FLEDTELL-RALRHGFRIAEVPVR---YRAGESKLN 200
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 5-140 6.71e-28

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 107.10  E-value: 6.71e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413    5 VIIPVYNAENTIRKAVKSI-DTTH-DVEIICINDGSTDRTKQVLTELQKEVKHLIVYHQD-NQGAAKSRNMGLSAMSDDI 81
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLlNQTYpNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPeNRGKAGARNAGLRAATGDY 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 515743413   82 daFMFLDADDQFLPGKMDQMIQYYEKNEHlDIVIGQIGRGlNGDWKVIPTHEDIHREAI 140
Cdd:pfam00535  82 --IAFLDADDEVPPDWLEKLVEALEEDGA-DVVVGSRYVI-FGETGEYRRASRITLSRL 136
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-117 5.62e-26

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 101.43  E-value: 5.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSI--DTTHDVEIICINDGSTDRTKQVLTELQKEVKHLIVY-HQDNQGAAKSRNMGLSAMSDDI 81
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLlaQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRViNEENQGLAAARNAGLKAARGEY 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 515743413  82 daFMFLDADDQFLPGKMDQMIQYYEKNEHLDIVIGQ 117
Cdd:cd00761   81 --ILFLDADDLLLPDWLERLVAELLADPEADAVGGP 114
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 5-116 1.36e-20

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 88.01  E-value: 1.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSI----DTTHDVEIICINDGSTDRTKQVLTELQKEVKHL-IVYHQDNQGAAKSRNMGLSAMSD 79
Cdd:cd04179    1 VVIPAYNEEENIPELVERLlavlEEGYDYEIIVVDDGSTDGTAEIARELAARVPRVrVIRLSRNFGKGAAVRAGFKAARG 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 515743413  80 DIDAFMflDADDQFLPGKMDQMIQYYEKNEHlDIVIG 116
Cdd:cd04179   81 DIVVTM--DADLQHPPEDIPKLLEKLLEGGA-DVVIG 114
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 2-126 3.89e-19

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 86.64  E-value: 3.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   2 KLAVIIPVYNAENTIRKAVKSI--DTTHDVEIICINDGSTDRTKQVLTELQKEVKHLIVYHQDNQGAAKSRNMGLSAMSD 79
Cdd:PRK10073   7 KLSIIIPLYNAGKDFRAFMESLiaQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQANAGVSVARNTGLAVATG 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 515743413  80 DIDAFMflDADDQFLPGKMDQMIQYYEKNeHLDIVIGqigrglNGDW 126
Cdd:PRK10073  87 KYVAFP--DADDVVYPTMYETLMTMALED-DLDVAQC------NADW 124
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 1-109 8.92e-18

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 82.48  E-value: 8.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   1 MKLAVIIPVYNAENTIRKAVKSIDT----THDVEIICINDGSTDRTKQVLTELQKEVKHLIVYHQD-NQGAAKSRNMGLS 75
Cdd:COG1215   29 PRVSVIIPAYNEEAVIEETLRSLLAqdypKEKLEVIVVDDGSTDETAEIARELAAEYPRVRVIERPeNGGKAAALNAGLK 108

                         90       100       110
                 ....*....|....*....|....*....|....
gi 515743413  76 AMSDDIdaFMFLDADDQFLPGKMDQMIQYYEKNE 109
Cdd:COG1215  109 AARGDI--VVFLDADTVLDPDWLRRLVAAFADPG 140
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-104 3.43e-16

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 76.18  E-value: 3.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   1 MKLAVIIPVYNAENTIRKAVKSI--DTTHDVEIICINDGSTDRTKQVLTELQ-KEVKhlIVYHQDNQGAAKSRNMGLSAM 77
Cdd:COG1216    3 PKVSVVIPTYNRPELLRRCLESLlaQTYPPFEVIVVDNGSTDGTAELLAALAfPRVR--VIRNPENLGFAAARNLGLRAA 80

                         90       100
                 ....*....|....*....|....*..
gi 515743413  78 SDDIdaFMFLDADDQFLPGKMDQMIQY 104
Cdd:COG1216   81 GGDY--LLFLDDDTVVEPDWLERLLAA 105
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 5-125 8.58e-15

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 71.49  E-value: 8.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSIDTTH--DVEIICINDGSTDRTKQVLTELQKEVKHLIVYHQDNQGAAKSR--NMGLSAMSDD 80
Cdd:cd06423    1 IIVPAYNEEAVIERTIESLLALDypKLEVIVVDDGSTDDTLEILEELAALYIRRVLVVRDKENGGKAGalNAGLRHAKGD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 515743413  81 IdaFMFLDADDQFLPGKMDQMIQYYEKNEHLDIVIGQIgRGLNGD 125
Cdd:cd06423   81 I--VVVLDADTILEPDALKRLVVPFFADPKVGAVQGRV-RVRNGS 122
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 5-116 5.12e-14

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 70.29  E-value: 5.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVksiDTTHD---------VEIICINDGSTDRTKQVLTELQKEVKHLI-VYHQD-NQGAAKSRNMG 73
Cdd:cd04188    1 VVIPAYNEEKRLPPTL---EEAVEyleerpsfsYEIIVVDDGSKDGTAEVARKLARKNPALIrVLTLPkNRGKGGAVRAG 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 515743413  74 LSAMSDDIDAFMflDADDQFLPGKMDQMIQyYEKNEHLDIVIG 116
Cdd:cd04188   78 MLAARGDYILFA--DADLATPFEELEKLEE-ALKTSGYDIAIG 117
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 5-117 1.88e-12

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 64.81  E-value: 1.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSIDTT-----HDVEIICINDGSTDRTKQVLTELQKEVKHLIVYHQdnqgaakSRNMG-LSAMS 78
Cdd:cd04187    1 IVVPVYNEEENLPELYERLKAVleslgYDYEIIFVDDGSTDRTLEILRELAARDPRVKVIRL-------SRNFGqQAALL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 515743413  79 DDI-----DAFMFLDADDQFLPGKMDQMIQYYEknEHLDIVIGQ 117
Cdd:cd04187   74 AGLdhargDAVITMDADLQDPPELIPEMLAKWE--EGYDVVYGV 115
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 5-90 3.91e-10

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 59.55  E-value: 3.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSI---DTTHD-VEIICINDGSTDRTKQVLTELQKEVKHLIVYHQDNQGAAKSRNMGLSAMSDD 80
Cdd:cd02525    4 IIIPVRNEEKYIEELLESLlnqSYPKDlIEIIVVDGGSTDGTREIVQEYAAKDPRIRLIDNPKRIQSAGLNIGIRNSRGD 83

                         90
                 ....*....|
gi 515743413  81 IdaFMFLDAD 90
Cdd:cd02525   84 I--IIRVDAH 91
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-108 7.88e-10

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 57.18  E-value: 7.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSI--DTTHDVEIICINDGSTDRTKQVLTELQKEVKhlIVYHQDNQGAAKSRNMGLsAMSDDiD 82
Cdd:cd04186    1 IIIVNYNSLEYLKACLDSLlaQTYPDFEVIVVDNASTDGSVELLRELFPEVR--LIRNGENLGFGAGNNQGI-REAKG-D 76

                         90       100
                 ....*....|....*....|....*.
gi 515743413  83 AFMFLDADDQFLPGKMDQMIQYYEKN 108
Cdd:cd04186   77 YVLLLNPDTVVEPGALLELLDAAEQD 102
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 5-140 1.01e-09

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 57.71  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENT--IRKAVKSI--DTTHDVEIICINDGS-TDRTKQVLTELQKEVKHLIVYHQDNQGAAKSRNMGLSAMSD 79
Cdd:cd04195    2 VLMSVYIKEKPefLREALESIlkQTLPPDEVVLVKDGPvTQSLNEVLEEFKRKLPLKVVPLEKNRGLGKALNEGLKHCTY 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515743413  80 DIDAFMflDADDQFLPGKMDQMIQYYEKNEHLDIVIGQIGR-GLNGDWKVI----PTHEDIHREAI 140
Cdd:cd04195   82 DWVARM--DTDDISLPDRFEKQLDFIEKNPEIDIVGGGVLEfDSDGNDIGKrrlpTSHDDILKFAR 145
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 5-203 2.04e-09

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 56.78  E-value: 2.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSID--TTHDVEIICINDGSTDRTKQVLTELQKEVKHLI------VYHQDNQGAAKSrnmglsa 76
Cdd:cd06433    2 IITPTYNQAETLEETIDSVLsqTYPNIEYIVIDGGSTDGTVDIIKKYEDKITYWIsepdkgIYDAMNKGIALA------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413  77 mSDDIdaFMFLDADDQFLPGKMDQMIQYYEKNEHLDIVIG--QIGRGlNGDWKVIPTHEDIHREAIVSLAEAPEilQSIg 154
Cdd:cd06433   75 -TGDI--IGFLNSDDTLLPGALLAVVAAFAEHPEVDVVYGdvLLVDE-NGRVIGRRRPPPFLDKFLLYGMPICH--QAT- 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 515743413 155 pggkLFKAK-FNTLR-FDEDVVFCEEHTFVTRAYLMARDIQLVPFIVYGYN 203
Cdd:cd06433  148 ----FFRRSlFEKYGgFDESYRIAADYDLLLRLLLAGKIFKYLPEVLAAFR 194
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 4-109 4.68e-09

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 55.71  E-value: 4.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   4 AVIIPVYNAENTIRKAVKSIDT-TH-DVEIICINDGSTDRTKQVLTELQKEVKH--LIVYHQDNQGAAKSRNMGLSAMSD 79
Cdd:cd04196    1 AVLMATYNGEKYLREQLDSILAqTYkNDELIISDDGSTDGTVEIIKEYIDKDPFiiILIRNGKNLGVARNFESLLQAADG 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 515743413  80 DIdaFMFLDADDQFLPGKMDQMIQYYEKNE 109
Cdd:cd04196   81 DY--VFFCDQDDIWLPDKLERLLKAFLKDD 108
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 2-95 7.25e-09

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 55.37  E-value: 7.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   2 KLAVIIPVYNAENTIRKAVKSIDTTHDvEIICINDGSTDRTKQVLTELQkeVKhliVYHQDNQGAAKSRNMGLSAMSDD- 80
Cdd:cd02511    1 TLSVVIITKNEERNIERCLESVKWAVD-EIIVVDSGSTDRTVEIAKEYG--AK---VYQRWWDGFGAQRNFALELATNDw 74

                         90
                 ....*....|....*
gi 515743413  81 IdafMFLDADDQFLP 95
Cdd:cd02511   75 V---LSLDADERLTP 86
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-122 8.27e-09

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 55.37  E-value: 8.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSI---DTTHD-VEIICINDGSTDRTKQVLT-ELQKEVKHLIVYHQD---NQGAAKSRNMGLSA 76
Cdd:cd04192    1 VVIAARNEAENLPRLLQSLsalDYPKEkFEVILVDDHSTDGTVQILEfAAAKPNFQLKILNNSrvsISGKKNALTTAIKA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 515743413  77 MSDDIdaFMFLDADDQFLPGKMDQMIQYYEKNEHLDI---VIGQIGRGL 122
Cdd:cd04192   81 AKGDW--IVTTDADCVVPSNWLLTFVAFIQKEQIGLVagpVIYFKGKSL 127
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 2-118 2.77e-08

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 54.13  E-value: 2.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   2 KLAVIIPVYNAENTIRKAVKSIDT----THDVEIICINDGSTDRTKQVLTELQKEVKHLIVYHQdNQGAAKSRNMGLSAM 77
Cdd:cd06439   30 TVTIIIPAYNEEAVIEAKLENLLAldypRDRLEIIVVSDGSTDGTAEIAREYADKGVKLLRFPE-RRGKAAALNRALALA 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 515743413  78 SDDIDAFMflDADDQFLPGKMDQMIQYYEkNEHLDIVIGQI 118
Cdd:cd06439  109 TGEIVVFT--DANALLDPDALRLLVRHFA-DPSVGAVSGEL 146
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 5-120 2.72e-07

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 50.53  E-value: 2.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSI---DTTHDVEIICINDGSTDRTKQVLTELQKEVK----HLIVYHQDNQ-----GAAKSRNM 72
Cdd:cd06913    1 IILPVHNGEQWLDECLESVlqqDFEGTLELSVFNDASTDKSAEIIEKWRKKLEdsgvIVLVGSHNSPspkgvGYAKNQAI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 515743413  73 GLSAMSddidAFMFLDADDQFLPGKMDqmIQYYEKNEHLDIVIG-QIGR 120
Cdd:cd06913   81 AQSSGR----YLCFLDSDDVMMPQRIR--LQYEAALQHPNSIIGcQVRR 123
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 5-90 4.94e-07

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 49.50  E-value: 4.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSID--TTHDVEIICINDGSTDRTKQVLTELQKE----VKHliVYHQDNqG--AAKSRNMGLSA 76
Cdd:cd06420    1 LIITTYNRPEALELVLKSVLnqSILPFEVIIADDGSTEETKELIEEFKSQfpipIKH--VWQEDE-GfrKAKIRNKAIAA 77

                         90
                 ....*....|....
gi 515743413  77 MSDDIdaFMFLDAD 90
Cdd:cd06420   78 AKGDY--LIFIDGD 89
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 3-103 1.20e-06

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 48.72  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   3 LAVIIPVYNAENTIRKAVKSI--DTTHDVEIICINDGSTDRTKQVLTELQKEVKHlivyhqdnqgAAKSR----NMGLSA 76
Cdd:cd02522    1 LSIIIPTLNEAENLPRLLASLrrLNPLPLEIIVVDGGSTDGTVAIARSAGVVVIS----------SPKGRarqmNAGAAA 70

                         90       100
                 ....*....|....*....|....*..
gi 515743413  77 MSDDIdaFMFLDADDQFLPGKMDQMIQ 103
Cdd:cd02522   71 ARGDW--LLFLHADTRLPPDWDAAIIE 95
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 5-140 1.34e-06

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 48.68  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYN-AENtIRKAVKSIDTT---HDVEIICINDGSTDRTKQVLTELQKEV--KHLIVYHQDNQ-GAAKSRnmGLSAM 77
Cdd:cd06442    1 IIIPTYNeREN-IPELIERLDAAlkgIDYEIIVVDDNSPDGTAEIVRELAKEYprVRLIVRPGKRGlGSAYIE--GFKAA 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515743413  78 SDDIDAFMflDADDQFLPGKMDQMIQYYEKNEHlDIVIGQ--IGRGLNGDWkviptheDIHREAI 140
Cdd:cd06442   78 RGDVIVVM--DADLSHPPEYIPELLEAQLEGGA-DLVIGSryVEGGGVEGW-------GLKRKLI 132
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 4-103 7.33e-06

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 46.89  E-value: 7.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413    4 AVIIPVYNAENT--IRKAVKSIDTTHD--VEIICINDGSTDRTKQVLTELqKEVKHLIVYHQDNQ---GAAKSRNMGLSA 76
Cdd:pfam10111   1 SVVIPVYNGEKThwIQERILNQTFQYDpeFELIIINDGSTDKTLEEVSSI-KDHNLQVYYPNAPDttySLAASRNRGTSH 79

                          90       100
                  ....*....|....*....|....*..
gi 515743413   77 MSDDIdaFMFLDADDQFLPGKMDQMIQ 103
Cdd:pfam10111  80 AIGEY--ISFIDGDCLWSPDKFEKQLK 104
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 2-114 2.40e-05

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 44.50  E-value: 2.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   2 KLAVIIPVYNA-ENTIRKAVKSI--DTTHDVEIICINDGSTDR-TKQVLTELQKE---VKhlIVYHQDNQGAAKSRNMGL 74
Cdd:cd04184    2 LISIVMPVYNTpEKYLREAIESVraQTYPNWELCIADDASTDPeVKRVLKKYAAQdprIK--VVFREENGGISAATNSAL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 515743413  75 SAMSDDIDAfmFLDADDQFLPGKMDQMIQYYEKNEHLDIV 114
Cdd:cd04184   80 ELATGEFVA--LLDHDDELAPHALYEVVKALNEHPDADLI 117
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 2-114 3.68e-05

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 45.11  E-value: 3.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   2 KLAVIIPVYNAENT----IRKAVKSIDT-THDVEIICINDGSTDRTKQVLTEL-QKEVKHLI-VYHQDNQGAAKSRNMGL 74
Cdd:PRK10714   7 KVSVVIPVYNEQESlpelIRRTTAACESlGKEYEILLIDDGSSDNSAEMLVEAaQAPDSHIVaILLNRNYGQHSAIMAGF 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 515743413  75 SAMSDDIdaFMFLDADDQFLPGKMDQMIQYYEknEHLDIV 114
Cdd:PRK10714  87 SHVTGDL--IITLDADLQNPPEEIPRLVAKAD--EGYDVV 122
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
1-91 7.42e-05

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 44.01  E-value: 7.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   1 MKLAVIIPVYNAENTIRK---AVKSIDTTHDV--EIICINDGSTDRTKQVLTELQKEVKH---LIVYHQDNQGAAKSRNM 72
Cdd:NF038302   1 LDFTVAIPTYNGANRLPEvleRLRSQIGTESLswEIIVVDNNSTDNTAQVVQEYQKNWPSpypLRYCFEPQQGAAFARQR 80

                         90       100
                 ....*....|....*....|
gi 515743413  73 GLS-AMSDDIDafmFLDaDD 91
Cdd:NF038302  81 AIQeAKGELIG---FLD-DD 96
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 1-126 2.22e-04

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 41.99  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   1 MKLAVIIPVYNA-ENT------IRKAVKSIDtthDVEIICINDGSTDRTKQVLTELQK---EVKHLIVYHQDNQGAAKSR 70
Cdd:PLN02726   9 MKYSIIVPTYNErLNIalivylIFKALQDVK---DFEIIVVDDGSPDGTQDVVKQLQKvygEDRILLRPRPGKLGLGTAY 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515743413  71 NMGLSAMSDDIDAFMflDADDQFLPGKMDQMIQyYEKNEHLDIVIG---QIGRGLNGdW 126
Cdd:PLN02726  86 IHGLKHASGDFVVIM--DADLSHHPKYLPSFIK-KQRETGADIVTGtryVKGGGVHG-W 140
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 3-73 3.15e-03

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 38.98  E-value: 3.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   3 LAVIIPVYNAENTIRKAVKSI----------DTTHDVEIICINDGSTDRTKQVLTELQKEVKHLIVyhqDNQGAAKSRNM 72
Cdd:PTZ00260  72 LSIVIPAYNEEDRLPKMLKETikylesrsrkDPKFKYEIIIVNDGSKDKTLKVAKDFWRQNINPNI---DIRLLSLLRNK 148


                 .
gi 515743413  73 G 73
Cdd:PTZ00260 149 G 149
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 5-89 4.76e-03

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 38.34  E-value: 4.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYN-AENTIRKAVKS-IDTT-----HdvEIICINDGStdrTKQVLTELQKEVKHL------IVYHQDNQGAAKSRN 71
Cdd:cd02510    2 VIIIFHNeALSTLLRTVHSvINRTppellK--EIILVDDFS---DKPELKLLLEEYYKKylpkvkVLRLKKREGLIRARI 76

                         90
                 ....*....|....*...
gi 515743413  72 MGLSAMSDDIdaFMFLDA 89
Cdd:cd02510   77 AGARAATGDV--LVFLDS 92
EpsO_like cd06438
EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is ...
 5-101 5.28e-03

EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.


Pssm-ID: 133060 [Multi-domain]  Cd Length: 183  Bit Score: 37.58  E-value: 5.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515743413   5 VIIPVYNAENTIRKAVKSI---DTTHD-VEIICINDGSTDRTKQVLTELQKEVkhliVYHQDNQGAAKSRNMG-----LS 75
Cdd:cd06438    1 ILIPAHNEEAVIGNTVRSLkaqDYPRElYRIFVVADNCTDDTAQVARAAGATV----LERHDPERRGKGYALDfgfrhLL 76

                         90       100
                 ....*....|....*....|....*.
gi 515743413  76 AMSDDIDAFMFLDADDQFLPGKMDQM 101
Cdd:cd06438   77 NLADDPDAVVVFDADNLVDPNALEEL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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