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Conserved domains on  [gi|515857186|ref|WP_017287814|]
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MULTISPECIES: urea ABC transporter permease subunit UrtB [Leptolyngbya]

Protein Classification

ABC transporter permease( domain architecture ID 359)

ABC transporter permease is the transmembrane subunit (TM) found in type 1 periplasmic-binding protein (PBP1)-dependent ATP-binding cassette (ABC) transporters which generally involved in the uptake of a broad range of substrates including metal ions, amino acids, sugars and peptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TM_PBP1_branched-chain-AA_like super family cl00454
Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette ...
28-382 7.05e-99

Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of monosaccharides including ribose, galactose, and arabinose. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. This group includes Escherichia coli LivM and LivH, two TMs which heterodimerize to form the translocation pathway of the E. coli branched-chain AA LIV-1/LS transporter. This transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) and LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine. Included in this group are proteins from transport systems that contain a single TM which homodimerizes to generate the transmembrane pore; for example E. coli RbsC, AlsC, and MglC, the TMs of the high affinity ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also to be involved in low affinity ribose transport.


The actual alignment was detected with superfamily member TIGR03409:

Pssm-ID: 444914 [Multi-domain]  Cd Length: 291  Bit Score: 295.69  E-value: 7.05e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186   28 IVFGLMGVINMAHGELMMLGAYTTFVVQNALKPLGgiWFDAYIFVALIAAFIVTAIFGVVLERGVIRYLYGRPLETLLAT 107
Cdd:TIGR03409  23 ITFGQMGVINMAHGEFIMIGAYTTYVVQQLFSSPG--LADLYLLIAIPLAFLVSALLGALIERTVIRHLYGRPLDTLLAT 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  108 WGVSLILQQLVRSVswqfviglivfcafffgglwflakrpnfeqfrgwaialllpisagialslgnylgqaygllmtkpw 187
Cdd:TIGR03409 101 WGISLILQQAVRSI------------------------------------------------------------------ 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  188 FGAQNVDVTAPRWLRGGLSIADT-QLSYARIFIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDAL 266
Cdd:TIGR03409 115 FGAPNVPVTAPEWLSGGLEITGAlSLPYNRLFIIVLALAVLLALALLLYRTRLGLRVRAVTQNRSMAAALGINTRRVDAL 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  267 AFAIGSGLAGVAGCAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIIAALAIGTANyiigsnllvdafsffpplaE 346
Cdd:TIGR03409 195 TFALGSGIAGVAGVALTLIGNVGPTLGQLYIVDSFLVVVFGGVGSLWGTVVAAFGLGVLN-------------------K 255
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 515857186  347 FFRFFSTISMAKVMVFALIIVFLQFRPAGLFPQKGR 382
Cdd:TIGR03409 256 ILEYFTGASLAKVLVLVLIILFLQWRPQGLFALKGR 291
 
Name Accession Description Interval E-value
urea_trans_UrtB TIGR03409
urea ABC transporter, permease protein UrtB; Members of this protein family are ABC ...
28-382 7.05e-99

urea ABC transporter, permease protein UrtB; Members of this protein family are ABC transporter permease proteins associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 200272 [Multi-domain]  Cd Length: 291  Bit Score: 295.69  E-value: 7.05e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186   28 IVFGLMGVINMAHGELMMLGAYTTFVVQNALKPLGgiWFDAYIFVALIAAFIVTAIFGVVLERGVIRYLYGRPLETLLAT 107
Cdd:TIGR03409  23 ITFGQMGVINMAHGEFIMIGAYTTYVVQQLFSSPG--LADLYLLIAIPLAFLVSALLGALIERTVIRHLYGRPLDTLLAT 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  108 WGVSLILQQLVRSVswqfviglivfcafffgglwflakrpnfeqfrgwaialllpisagialslgnylgqaygllmtkpw 187
Cdd:TIGR03409 101 WGISLILQQAVRSI------------------------------------------------------------------ 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  188 FGAQNVDVTAPRWLRGGLSIADT-QLSYARIFIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDAL 266
Cdd:TIGR03409 115 FGAPNVPVTAPEWLSGGLEITGAlSLPYNRLFIIVLALAVLLALALLLYRTRLGLRVRAVTQNRSMAAALGINTRRVDAL 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  267 AFAIGSGLAGVAGCAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIIAALAIGTANyiigsnllvdafsffpplaE 346
Cdd:TIGR03409 195 TFALGSGIAGVAGVALTLIGNVGPTLGQLYIVDSFLVVVFGGVGSLWGTVVAAFGLGVLN-------------------K 255
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 515857186  347 FFRFFSTISMAKVMVFALIIVFLQFRPAGLFPQKGR 382
Cdd:TIGR03409 256 ILEYFTGASLAKVLVLVLIILFLQWRPQGLFALKGR 291
LivH COG0559
Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport ...
28-382 1.29e-56

Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440325 [Multi-domain]  Cd Length: 290  Bit Score: 186.81  E-value: 1.29e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  28 IVFGLMGVINMAHGELMMLGAYTTFVVQNalkplggiWFDAYIFVALIAAFIVTAIFGVVLERGVIRYLYGRP-LETLLA 106
Cdd:COG0559   27 LIFGVMGVINFAHGEFVMLGAYVAYTLAT--------LLGLPLWLALLLAVLVAALLGVLLERLVIRPLRGAPpLALLLA 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 107 TWGVSLILQQLVRSVswqfviglivfcafffgglwflakrpnfeqfrgwaialllpisagialslgnylgqaygllmtkp 186
Cdd:COG0559   99 TIGLSLVLQGLVLLI----------------------------------------------------------------- 113
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 187 wFGAQNVDVtaPRWLRGGLSIADTQLSYARIFIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDAL 266
Cdd:COG0559  114 -FGADPRSF--PALLSGSVELGGVSIPAYRLFIIVVALVLLAALWLFLRRTRLGLAMRAVAQNREAARLMGINVDRVIAL 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 267 AFAIGSGLAGVAGCAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIIAALAIGTANyiigsnllvdafsffpplaE 346
Cdd:COG0559  191 TFALGAALAGLAGVLLAPIYSVSPTMGFLLGLKAFAAVVLGGLGSIPGAVVGGLLLGLAE-------------------S 251
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 515857186 347 FFRFFSTISMAKVMVFALIIVFLQFRPAGLFPQKGR 382
Cdd:COG0559  252 LGAAYLPSGYKDVVAFVLLILVLLVRPQGLFGRKER 287
TM_PBP1_LivH_like cd06582
Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two ...
28-377 2.73e-43

Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.


Pssm-ID: 119324 [Multi-domain]  Cd Length: 272  Bit Score: 151.81  E-value: 2.73e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  28 IVFGLMGVINMAHGELMMLGAYTTFVVqnalkplgGIWFDAYIFVALIAAFIVTAIFGVVLERGVIRYLYGRPLETLLAT 107
Cdd:cd06582   17 LIFGVTGVINFAHGEFYMLGAYVAYTL--------LVALGLPFWLALLLALLVAALLGVLLERLVLRPLRGAPLLTLLIT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 108 WGVSLILQQLVRSVSWQfviglivfcafffgglwflakrpnfeqfrgwaialllpisagialslgnylgqaygllmtkpw 187
Cdd:cd06582   89 FGGLLILLQGLLLIFGG--------------------------------------------------------------- 105
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 188 fgaqNVDVTAPRWLRGGLSIADTQLSYARIFIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDALA 267
Cdd:cd06582  106 ----DPRVPPPPLLSGSVELGGVTIPPYRLFIIAVALVLLAALYLFLRRTRLGRAIRAVAQNPEAARLLGINVRRVFALT 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 268 FAIGSGLAGVAGCAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIIAALAIGTANyiigsnllvdafsffpplaEF 347
Cdd:cd06582  182 FALGAALAGLAGVLLAPITGVSPTMGLLLLLKAFAAVVLGGLGSIPGAVVGGLLLGLAE-------------------SL 242
                        330       340       350
                 ....*....|....*....|....*....|
gi 515857186 348 FRFFSTISMAKVMVFALIIVFLQFRPAGLF 377
Cdd:cd06582  243 AAAYLSSGYKDAVAFVLLILVLLVRPQGLF 272
BPD_transp_2 pfam02653
Branched-chain amino acid transport system / permease component; This is a large family mainly ...
28-351 1.05e-14

Branched-chain amino acid transport system / permease component; This is a large family mainly comprising high-affinity branched-chain amino acid transporter proteins such as E. coli LivH and LivM, both of which are form the LIV-I transport system. Also found with in this family are proteins from the galactose transport system permease and a ribose transport system.


Pssm-ID: 396977 [Multi-domain]  Cd Length: 269  Bit Score: 73.45  E-value: 1.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186   28 IVFGLMGVINMAHGELMMLGAYTTFVVQNAlkplggiwFDAYIFVALIAAFIVTAIFGVVLERGVIRYLYGRPLETLLAT 107
Cdd:pfam02653  21 LIYGIAGVINLGHGGFMMLGAYVAAMLLNL--------LGPGLWLALPVGILVGAAVGLLIGILTLRLKINEVIITLLLN 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  108 WGVSLILQQLVRSVSWQFVIGLIVFCAFFFGGlwflakrpnfeqfrgwaialllpisagialslgnylgqaygllmtkpw 187
Cdd:pfam02653  93 LAALGLALFLVTGILGGEGGTSGITGPSGFPG------------------------------------------------ 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  188 fgaqnvdvtaprwlrgglsiadTQLSYARIFIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDALA 267
Cdd:pfam02653 125 ----------------------AFLSFAFAFIFLLALLLVLALWLLLYRTKFGRALRAVGENEEAARAAGINVKKLKLLT 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  268 FAIGSGLAGVAGCAVSLLGSVGP--NTGQNYIVDTFMVVVVGGVGKLVGSIIAALAIGTANyiigsNLLVDAFSFFPPLA 345
Cdd:pfam02653 183 FVISGALAGLAGALLALYTGVVPpsNFGVGLGLDAIAAVVLGGAGSPIGVVIGSLIIGLVQ-----SLGLGALGSPPELS 257

                  ....*.
gi 515857186  346 EFFRFF 351
Cdd:pfam02653 258 LLVLGA 263
PRK10740 PRK10740
high-affinity branched-chain amino acid ABC transporter permease LivH;
28-377 8.58e-08

high-affinity branched-chain amino acid ABC transporter permease LivH;


Pssm-ID: 182689 [Multi-domain]  Cd Length: 308  Bit Score: 53.39  E-value: 8.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  28 IVFGLMGVINMAHGELMMLGAYTTFVVQNALKPLGGIWFDAYIFVALIAAFIVTAIFGVVLERGVIRYL-YGRPLETLLA 106
Cdd:PRK10740  31 MVYGIIGMINFAHGEVYMIGSYVSFMIIAALMMMGIDTSWLLVAAGFVGAIVIASAYGWSIERVAYRPVrNSKRLIALIS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 107 TWGVSLILQQLVRSVSWQFVIGLivfcAFFFGGLWFLAKRPNFEQfrgwaialllpisagialslgnylgqaygllmtkp 186
Cdd:PRK10740 111 AIGMSIFLQNYVSLTEGSRDVAL----PSLFNGQWVVGHSENFSA----------------------------------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 187 wfgaqnvdvtaprwlrgglSIADTQLSyarifIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDAL 266
Cdd:PRK10740 152 -------------------SITTMQAV-----IWIVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIAL 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 267 AFAIGSGLAGVAGCAV-SLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIIAALAIGTANYIIGSNLlvdafsffppla 345
Cdd:PRK10740 208 TFVIGAAMAAVAGVLLgQFYGVINPYIGFMAGMKAFTAAVLGGIGSIPGAMIGGLILGIAEALSSAYL------------ 275
                        330       340       350
                 ....*....|....*....|....*....|..
gi 515857186 346 effrffsTISMAKVMVFALIIVFLQFRPAGLF 377
Cdd:PRK10740 276 -------STEYKDVVSFALLILVLLVMPTGIL 300
 
Name Accession Description Interval E-value
urea_trans_UrtB TIGR03409
urea ABC transporter, permease protein UrtB; Members of this protein family are ABC ...
28-382 7.05e-99

urea ABC transporter, permease protein UrtB; Members of this protein family are ABC transporter permease proteins associated with urea transport and metabolism. This protein is found in a conserved five-gene transport operon typically found adjacent to urease genes. It was shown in Cyanobacteria that disruption leads to the loss of high-affinity urea transport activity. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 200272 [Multi-domain]  Cd Length: 291  Bit Score: 295.69  E-value: 7.05e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186   28 IVFGLMGVINMAHGELMMLGAYTTFVVQNALKPLGgiWFDAYIFVALIAAFIVTAIFGVVLERGVIRYLYGRPLETLLAT 107
Cdd:TIGR03409  23 ITFGQMGVINMAHGEFIMIGAYTTYVVQQLFSSPG--LADLYLLIAIPLAFLVSALLGALIERTVIRHLYGRPLDTLLAT 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  108 WGVSLILQQLVRSVswqfviglivfcafffgglwflakrpnfeqfrgwaialllpisagialslgnylgqaygllmtkpw 187
Cdd:TIGR03409 101 WGISLILQQAVRSI------------------------------------------------------------------ 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  188 FGAQNVDVTAPRWLRGGLSIADT-QLSYARIFIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDAL 266
Cdd:TIGR03409 115 FGAPNVPVTAPEWLSGGLEITGAlSLPYNRLFIIVLALAVLLALALLLYRTRLGLRVRAVTQNRSMAAALGINTRRVDAL 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  267 AFAIGSGLAGVAGCAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIIAALAIGTANyiigsnllvdafsffpplaE 346
Cdd:TIGR03409 195 TFALGSGIAGVAGVALTLIGNVGPTLGQLYIVDSFLVVVFGGVGSLWGTVVAAFGLGVLN-------------------K 255
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 515857186  347 FFRFFSTISMAKVMVFALIIVFLQFRPAGLFPQKGR 382
Cdd:TIGR03409 256 ILEYFTGASLAKVLVLVLIILFLQWRPQGLFALKGR 291
LivH COG0559
Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport ...
28-382 1.29e-56

Branched-chain amino acid ABC-type transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440325 [Multi-domain]  Cd Length: 290  Bit Score: 186.81  E-value: 1.29e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  28 IVFGLMGVINMAHGELMMLGAYTTFVVQNalkplggiWFDAYIFVALIAAFIVTAIFGVVLERGVIRYLYGRP-LETLLA 106
Cdd:COG0559   27 LIFGVMGVINFAHGEFVMLGAYVAYTLAT--------LLGLPLWLALLLAVLVAALLGVLLERLVIRPLRGAPpLALLLA 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 107 TWGVSLILQQLVRSVswqfviglivfcafffgglwflakrpnfeqfrgwaialllpisagialslgnylgqaygllmtkp 186
Cdd:COG0559   99 TIGLSLVLQGLVLLI----------------------------------------------------------------- 113
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 187 wFGAQNVDVtaPRWLRGGLSIADTQLSYARIFIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDAL 266
Cdd:COG0559  114 -FGADPRSF--PALLSGSVELGGVSIPAYRLFIIVVALVLLAALWLFLRRTRLGLAMRAVAQNREAARLMGINVDRVIAL 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 267 AFAIGSGLAGVAGCAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIIAALAIGTANyiigsnllvdafsffpplaE 346
Cdd:COG0559  191 TFALGAALAGLAGVLLAPIYSVSPTMGFLLGLKAFAAVVLGGLGSIPGAVVGGLLLGLAE-------------------S 251
                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 515857186 347 FFRFFSTISMAKVMVFALIIVFLQFRPAGLFPQKGR 382
Cdd:COG0559  252 LGAAYLPSGYKDVVAFVLLILVLLVRPQGLFGRKER 287
TM_PBP1_LivH_like cd06582
Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two ...
28-377 2.73e-43

Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.


Pssm-ID: 119324 [Multi-domain]  Cd Length: 272  Bit Score: 151.81  E-value: 2.73e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  28 IVFGLMGVINMAHGELMMLGAYTTFVVqnalkplgGIWFDAYIFVALIAAFIVTAIFGVVLERGVIRYLYGRPLETLLAT 107
Cdd:cd06582   17 LIFGVTGVINFAHGEFYMLGAYVAYTL--------LVALGLPFWLALLLALLVAALLGVLLERLVLRPLRGAPLLTLLIT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 108 WGVSLILQQLVRSVSWQfviglivfcafffgglwflakrpnfeqfrgwaialllpisagialslgnylgqaygllmtkpw 187
Cdd:cd06582   89 FGGLLILLQGLLLIFGG--------------------------------------------------------------- 105
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 188 fgaqNVDVTAPRWLRGGLSIADTQLSYARIFIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDALA 267
Cdd:cd06582  106 ----DPRVPPPPLLSGSVELGGVTIPPYRLFIIAVALVLLAALYLFLRRTRLGRAIRAVAQNPEAARLLGINVRRVFALT 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 268 FAIGSGLAGVAGCAVSLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIIAALAIGTANyiigsnllvdafsffpplaEF 347
Cdd:cd06582  182 FALGAALAGLAGVLLAPITGVSPTMGLLLLLKAFAAVVLGGLGSIPGAVVGGLLLGLAE-------------------SL 242
                        330       340       350
                 ....*....|....*....|....*....|
gi 515857186 348 FRFFSTISMAKVMVFALIIVFLQFRPAGLF 377
Cdd:cd06582  243 AAAYLSSGYKDAVAFVLLILVLLVRPQGLF 272
BPD_transp_2 pfam02653
Branched-chain amino acid transport system / permease component; This is a large family mainly ...
28-351 1.05e-14

Branched-chain amino acid transport system / permease component; This is a large family mainly comprising high-affinity branched-chain amino acid transporter proteins such as E. coli LivH and LivM, both of which are form the LIV-I transport system. Also found with in this family are proteins from the galactose transport system permease and a ribose transport system.


Pssm-ID: 396977 [Multi-domain]  Cd Length: 269  Bit Score: 73.45  E-value: 1.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186   28 IVFGLMGVINMAHGELMMLGAYTTFVVQNAlkplggiwFDAYIFVALIAAFIVTAIFGVVLERGVIRYLYGRPLETLLAT 107
Cdd:pfam02653  21 LIYGIAGVINLGHGGFMMLGAYVAAMLLNL--------LGPGLWLALPVGILVGAAVGLLIGILTLRLKINEVIITLLLN 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  108 WGVSLILQQLVRSVSWQFVIGLIVFCAFFFGGlwflakrpnfeqfrgwaialllpisagialslgnylgqaygllmtkpw 187
Cdd:pfam02653  93 LAALGLALFLVTGILGGEGGTSGITGPSGFPG------------------------------------------------ 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  188 fgaqnvdvtaprwlrgglsiadTQLSYARIFIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDALA 267
Cdd:pfam02653 125 ----------------------AFLSFAFAFIFLLALLLVLALWLLLYRTKFGRALRAVGENEEAARAAGINVKKLKLLT 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  268 FAIGSGLAGVAGCAVSLLGSVGP--NTGQNYIVDTFMVVVVGGVGKLVGSIIAALAIGTANyiigsNLLVDAFSFFPPLA 345
Cdd:pfam02653 183 FVISGALAGLAGALLALYTGVVPpsNFGVGLGLDAIAAVVLGGAGSPIGVVIGSLIIGLVQ-----SLGLGALGSPPELS 257

                  ....*.
gi 515857186  346 EFFRFF 351
Cdd:pfam02653 258 LLVLGA 263
LivM COG4177
ABC-type branched-chain amino acid transport system, permease component [Amino acid transport ...
28-385 5.78e-09

ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443336 [Multi-domain]  Cd Length: 285  Bit Score: 56.63  E-value: 5.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  28 IVFGLMGVINMAHGELMMLGAYTTFVVQnalkplggIWFDAYIFVALIAAFIVTAIFGVVLERGVIR----YLygrplet 103
Cdd:COG4177   23 LLLGYTGLLSLGHAAFFGIGAYAAALLT--------THLGLPFWLALLLAGLVAALLGLLIGLPALRlrgdYL------- 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 104 LLATWGVSLILQQLVRSVSWqfviglivfcafFFGGlwflakrpnfeqfrgwaialllpiSAGIAlslgnylgqaygllm 183
Cdd:COG4177   88 AIATLAFAEIVRLLALNLES------------LTGG------------------------ADGLS--------------- 116
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 184 tkpwfgaqnvDVTAPRWLrgGLSIADTQLSYarIFIIVLTIACLFGVYWFLNqTSWGLRIRAVTQNRSMSACLGIPTQKV 263
Cdd:COG4177  117 ----------GIPRPTLF--GLDLGSPLAFY--YLVLALLVLVLLLLRRLVR-SRFGRALRAIRENEIAAEALGINVTRY 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 264 DALAFAIGSGLAGVAGC-AVSLLGSVGPNTgqnyivdtfmvvvvgGVGKLVGSIIAALAIGTANYIIGSnlLVDAFsFFP 342
Cdd:COG4177  182 KLLAFVLSAALAGLAGAlYAHYVGFVSPES---------------FSFLLSIEILLMVVLGGLGSLLGP--VLGAV-LLV 243
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 515857186 343 PLAEFFRFFSTISMakVMVFALIIVFLQFRPAGLFPQKGRTVD 385
Cdd:COG4177  244 LLPELLRSLPEYRL--LIFGLLLILVVLFRPRGLAGLLRRLRR 284
PRK10740 PRK10740
high-affinity branched-chain amino acid ABC transporter permease LivH;
28-377 8.58e-08

high-affinity branched-chain amino acid ABC transporter permease LivH;


Pssm-ID: 182689 [Multi-domain]  Cd Length: 308  Bit Score: 53.39  E-value: 8.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  28 IVFGLMGVINMAHGELMMLGAYTTFVVQNALKPLGGIWFDAYIFVALIAAFIVTAIFGVVLERGVIRYL-YGRPLETLLA 106
Cdd:PRK10740  31 MVYGIIGMINFAHGEVYMIGSYVSFMIIAALMMMGIDTSWLLVAAGFVGAIVIASAYGWSIERVAYRPVrNSKRLIALIS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 107 TWGVSLILQQLVRSVSWQFVIGLivfcAFFFGGLWFLAKRPNFEQfrgwaialllpisagialslgnylgqaygllmtkp 186
Cdd:PRK10740 111 AIGMSIFLQNYVSLTEGSRDVAL----PSLFNGQWVVGHSENFSA----------------------------------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 187 wfgaqnvdvtaprwlrgglSIADTQLSyarifIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDAL 266
Cdd:PRK10740 152 -------------------SITTMQAV-----IWIVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIAL 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 267 AFAIGSGLAGVAGCAV-SLLGSVGPNTGQNYIVDTFMVVVVGGVGKLVGSIIAALAIGTANYIIGSNLlvdafsffppla 345
Cdd:PRK10740 208 TFVIGAAMAAVAGVLLgQFYGVINPYIGFMAGMKAFTAAVLGGIGSIPGAMIGGLILGIAEALSSAYL------------ 275
                        330       340       350
                 ....*....|....*....|....*....|..
gi 515857186 346 effrffsTISMAKVMVFALIIVFLQFRPAGLF 377
Cdd:PRK10740 276 -------STEYKDVVSFALLILVLLVMPTGIL 300
NupP COG4603
ABC-type guanosine uptake system NupNOPQ, permease component NupP [Nucleotide transport and ...
220-289 1.33e-07

ABC-type guanosine uptake system NupNOPQ, permease component NupP [Nucleotide transport and metabolism];


Pssm-ID: 443653 [Multi-domain]  Cd Length: 356  Bit Score: 52.82  E-value: 1.33e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 220 IVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDALAFAIGSGLAGVAGcAVSLLGSVG 289
Cdd:COG4603  200 LLIALLAAVLVWVLLNRTTLGYELRAVGLNPRAARYAGINVKRLIVLAMLISGALAGLAG-AVEVLGVQG 268
AraH COG1172
Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component ...
218-296 8.31e-07

Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440785  Cd Length: 322  Bit Score: 50.10  E-value: 8.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 218 FIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDALAFAIGSGLAGVAG-CAVSLLGSVGPNTGQNY 296
Cdd:COG1172  170 VPVLIALVVALVAWFLLRRTRFGRYIYAVGGNEEAARLSGINVRRVKILAYVLSGLLAGLAGiLLAARLGSAQPNAGSGY 249
NupQ COG1079
ABC-type guanosine uptake system NupNOPQ, permease subunit NupQ [Nucleotide transport and ...
219-284 2.13e-06

ABC-type guanosine uptake system NupNOPQ, permease subunit NupQ [Nucleotide transport and metabolism];


Pssm-ID: 440697 [Multi-domain]  Cd Length: 309  Bit Score: 48.91  E-value: 2.13e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515857186 219 IIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDALAFAIGSGLAGVAGCAVSL 284
Cdd:COG1079  150 LVYLALLLVPLVWWVLYRTRFGLRLRAVGENPAAADALGINVYRIRYLAVLIGGALAGLGGAYLSL 215
TM_PBP1_transp_TpRbsC_like cd06580
Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. ...
218-279 2.34e-06

Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters, which are mainly involved in the uptake of branched-chain amino acids (AAs) or in the uptake of monosaccharides including ribose, galactose, and arabinose, and which generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction.


Pssm-ID: 119322 [Multi-domain]  Cd Length: 234  Bit Score: 48.20  E-value: 2.34e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515857186 218 FIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDALAFAIGSGLAGVAG 279
Cdd:cd06580   96 YLLLLALLLVILVWLLLYRTRFGLRLRAVGENPRAARYAGINVKRVRLLAMLISGALAGLAG 157
TM_PBP1_transp_AraH_like cd06579
Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the ...
218-296 2.38e-06

Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group also contains E. coli RbsC, AlsC, and MglC, which are TMs of other monosaccharide transporters, the ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also be involved in low affinity ribose transport. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Proteins in this subgroup have a single TM which homodimerizes to generate the transmembrane pore.


Pssm-ID: 119321 [Multi-domain]  Cd Length: 263  Bit Score: 48.56  E-value: 2.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 218 FIIVLTIACLFGVYWFLNQTSWGLRIRAVTQNRSMSACLGIPTQKVDALAFAIGSGLAGVAG-CAVSLLGSVGPNTGQNY 296
Cdd:cd06579  120 VPVLIALAVALVAWFLLRRTRFGRYLYAVGGNPEAARLSGINVRRVKILAYVLSGLLAGLAGiLLAARLGSAQPTAGNGY 199
TM_PBP1_LivM_like cd06581
Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two ...
28-378 4.62e-06

Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.


Pssm-ID: 119323 [Multi-domain]  Cd Length: 268  Bit Score: 47.82  E-value: 4.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186  28 IVFGLMGVINMAHGELMMLGAYTTFVVQnalkplggIWFDAYIFVALIAAFIVTAIFGVVLERGVIRYlygRPLETLLAT 107
Cdd:cd06581   13 LLLGYAGQLSLGHAAFFGIGAYTAALLA--------TRLGLPFWLALLAAGLVAALVGLLLGLPALRL---RGVYFAIAT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 108 WGVSLILQQLVRSVSWqfviglivfcafFFGGlwflakrpnfeqfrgwaialllpiSAGIALslgnylgqaygllmtkpw 187
Cdd:cd06581   82 LAFAEIVRLLALNWSS------------LTGG------------------------SNGLSG------------------ 107
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 188 fgaqnvdvtAPRWLRGGLSIADTQLSYarIFIIVLTIACLFGVYWFLNqTSWGLRIRAVTQNRSMSACLGIPTQKVDALA 267
Cdd:cd06581  108 ---------IPPPLLGGLLLSSPLAFY--YLVLAVLLLVLLLLRRLVR-SPFGRALRAIRENEVAAEALGINVTRYKLLA 175
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515857186 268 FAIGSGLAGVAGCA-VSLLGSVGPNTgqnyivdtfmvvvvgGVGKLVGSIIAALAIGTANYIIGSnlLVDAFsFFPPLAE 346
Cdd:cd06581  176 FALSAALAGLAGALyAHYLGFVSPES---------------FGFALSIELLLMVVLGGLGSLLGP--VLGAA-LLVLLPE 237
                        330       340       350
                 ....*....|....*....|....*....|..
gi 515857186 347 FFRFFsTISMAKVMVFALIIVFLQFRPAGLFP 378
Cdd:cd06581  238 LLRSL-GPGLRLLVFGLLLILVVLFLPRGLVG 268
TM_PBP1_branched-chain-AA_like cd06574
Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette ...
217-279 1.94e-05

Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of monosaccharides including ribose, galactose, and arabinose. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. This group includes Escherichia coli LivM and LivH, two TMs which heterodimerize to form the translocation pathway of the E. coli branched-chain AA LIV-1/LS transporter. This transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) and LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine. Included in this group are proteins from transport systems that contain a single TM which homodimerizes to generate the transmembrane pore; for example E. coli RbsC, AlsC, and MglC, the TMs of the high affinity ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also to be involved in low affinity ribose transport.


Pssm-ID: 119320 [Multi-domain]  Cd Length: 266  Bit Score: 45.73  E-value: 1.94e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515857186 217 IFIIVLTIACLFGVYWFLNqTSWGLRIRAVTQNRSMSACLGIPTQKVDALAFAIGSGLAGVAG 279
Cdd:cd06574  124 VVLLLIVLLVLFLVIWFLR-TKLGLAMRATGDNPDMARSLGINVDRTRILGLVISNALAALGG 185
COG4120 COG4120
ABC-type uncharacterized transport system, permease component [General function prediction ...
217-280 1.14e-04

ABC-type uncharacterized transport system, permease component [General function prediction only];


Pssm-ID: 443296  Cd Length: 296  Bit Score: 43.57  E-value: 1.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515857186 217 IFIIVLTIACLFGVYWFLNqTSWGLRIRAVTQNRSMSACLGIPTQKVDALAFAIGSGLAGVAGC 280
Cdd:COG4120  136 LVLLVIVLVIKLLLDWFLK-TELGLALRATGDNPQMARALGINTDRMKILGLALSNGLVALSGA 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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