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Conserved domains on  [gi|515927810|ref|WP_017358393|]
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MULTISPECIES: anti-sigma factor antagonist [Bacillus]

Protein Classification

anti-sigma factor antagonist( domain architecture ID 10794536)

anti-sigma factor antagonist is a positive regulator of sigma factor activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 1-106 2.37e-31

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


:

Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 106.53  E-value: 2.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810    1 MNMSVKEHQIDQKTKISVSGEIDVYSAPQLRETLMPKAE--AGEHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKL 78
Cdd:TIGR00377   1 MNLNIETEVQEGVVVVRLSGELDAHTAPLLREKVTPAAErtGIRPIVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVL 80

                          90       100
                  ....*....|....*....|....*...
gi 515927810   79 ENLSERLVRLFEITGLKDIIDISAKSEG 106
Cdd:TIGR00377  81 VSVSPRVARLLDITGLLRIIPIYPTVEE 108
 
Name Accession Description Interval E-value
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 1-106 2.37e-31

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 106.53  E-value: 2.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810    1 MNMSVKEHQIDQKTKISVSGEIDVYSAPQLRETLMPKAE--AGEHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKL 78
Cdd:TIGR00377   1 MNLNIETEVQEGVVVVRLSGELDAHTAPLLREKVTPAAErtGIRPIVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVL 80

                          90       100
                  ....*....|....*....|....*...
gi 515927810   79 ENLSERLVRLFEITGLKDIIDISAKSEG 106
Cdd:TIGR00377  81 VSVSPRVARLLDITGLLRIIPIYPTVEE 108
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 5-100 1.89e-27

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 96.44  E-value: 1.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810   5 VKEHQIDQKTKISVSGEIDVYSAPQLRETLMPKAEAG-EHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLENLSE 83
Cdd:cd07043    1 ITVEERGGVLVVRLSGELDAATAPELREALEELLAEGpRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSP 80

                         90
                 ....*....|....*..
gi 515927810  84 RLVRLFEITGLKDIIDI 100
Cdd:cd07043   81 AVRRVLELTGLDRLFPI 97
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 4-94 3.75e-24

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 87.99  E-value: 3.75e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810   4 SVKEHQIDQKTKISVSGEIDVYSAPQLRETLMPKAEAG-EHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLENLS 82
Cdd:COG1366    1 SIPVEVRDGVLVLPLIGELDAARAPELREALLEALETGaRRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVS 80

                         90
                 ....*....|..
gi 515927810  83 ERLVRLFEITGL 94
Cdd:COG1366   81 PAVARVLELTGL 92
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 16-105 1.28e-21

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 81.89  E-value: 1.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810   16 ISVSGEIDVYSAPQLRETLMPKAEAGE--HLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLENLSERLVRLFEITG 93
Cdd:pfam01740  13 LRLDGPLDFANAESLRERLLRALEEGEikHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPEVARTLEKTG 92

                          90
                  ....*....|..
gi 515927810   94 LKDIIDISAKSE 105
Cdd:pfam01740  93 LDDIIKIFPTVA 104
 
Name Accession Description Interval E-value
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 1-106 2.37e-31

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 106.53  E-value: 2.37e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810    1 MNMSVKEHQIDQKTKISVSGEIDVYSAPQLRETLMPKAE--AGEHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKL 78
Cdd:TIGR00377   1 MNLNIETEVQEGVVVVRLSGELDAHTAPLLREKVTPAAErtGIRPIVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVL 80

                          90       100
                  ....*....|....*....|....*...
gi 515927810   79 ENLSERLVRLFEITGLKDIIDISAKSEG 106
Cdd:TIGR00377  81 VSVSPRVARLLDITGLLRIIPIYPTVEE 108
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 5-100 1.89e-27

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 96.44  E-value: 1.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810   5 VKEHQIDQKTKISVSGEIDVYSAPQLRETLMPKAEAG-EHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLENLSE 83
Cdd:cd07043    1 ITVEERGGVLVVRLSGELDAATAPELREALEELLAEGpRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSP 80

                         90
                 ....*....|....*..
gi 515927810  84 RLVRLFEITGLKDIIDI 100
Cdd:cd07043   81 AVRRVLELTGLDRLFPI 97
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 4-94 3.75e-24

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 87.99  E-value: 3.75e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810   4 SVKEHQIDQKTKISVSGEIDVYSAPQLRETLMPKAEAG-EHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLENLS 82
Cdd:COG1366    1 SIPVEVRDGVLVLPLIGELDAARAPELREALLEALETGaRRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVS 80

                         90
                 ....*....|..
gi 515927810  83 ERLVRLFEITGL 94
Cdd:COG1366   81 PAVARVLELTGL 92
SpoIIAA COG5815
Stage II sporulation protein SpoIIAA (antagonist of anti-sigma F factor) [Cell cycle control, ...
 3-109 5.85e-24

Stage II sporulation protein SpoIIAA (antagonist of anti-sigma F factor) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444517  Cd Length: 110  Bit Score: 87.88  E-value: 5.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810   3 MSVKEHQIDQKTKISVSGEIDVYSAPQLRETLMPKAEAG--EHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLEN 80
Cdd:COG5815    1 MEVDFEKKGDTLIVRLEGELDHHTAEELREKIDRAIEKGgvKHLILNLEGVSFMDSSGLGVILGRYKKIKALGGKVAVIN 80

                         90       100
                 ....*....|....*....|....*....
gi 515927810  81 LSERLVRLFEITGLKDIIDISAKSEGGVQ 109
Cdd:COG5815   81 VSPQVKRIFELSGLFKIIKIYDSEEEALE 109
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 16-105 1.28e-21

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 81.89  E-value: 1.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810   16 ISVSGEIDVYSAPQLRETLMPKAEAGE--HLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLENLSERLVRLFEITG 93
Cdd:pfam01740  13 LRLDGPLDFANAESLRERLLRALEEGEikHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPEVARTLEKTG 92

                          90
                  ....*....|..
gi 515927810   94 LKDIIDISAKSE 105
Cdd:pfam01740  93 LDDIIKIFPTVA 104
MlaB COG3113
Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, ...
 3-99 1.67e-19

Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, contains STAS domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442347 [Multi-domain]  Cd Length: 97  Bit Score: 76.06  E-value: 1.67e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810   3 MSVKEHQIDQKTKISVSGEIDVYSAPQLRETLMPKAEAGEHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLENLS 82
Cdd:COG3113    1 MSEALLWNAEGGTLRLSGELTRDTVLALWAQLLALLAAGGAVEIDLSGVTRVDSAGLALLLELLREARAQGKTLRLTGVP 80

                         90
                 ....*....|....*..
gi 515927810  83 ERLVRLFEITGLKDIID 99
Cdd:COG3113   81 EQLRTLAALYGLDELLP 97
STAS_2 pfam13466
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 16-94 7.05e-16

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 433231 [Multi-domain]  Cd Length: 80  Bit Score: 66.48  E-value: 7.05e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515927810   16 ISVSGEIDVYSAPQLRETLMPKAEAGEHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLENLSERLVRLFEITGL 94
Cdd:pfam13466   1 LSLSGELDADTAPALREALLAALAAGSPVVVDLSGVERVDSAGLALLLALARRARARGKRLVLRGLPPALLRLLRLLGL 79
spore_II_AA TIGR02886
anti-sigma F factor antagonist; The anti-sigma F factor antagonist, also called stage II ...
 1-100 3.67e-13

anti-sigma F factor antagonist; The anti-sigma F factor antagonist, also called stage II sporulation protein AA, is a protein universal among endospore-forming bacteria, all of which belong to the Firmcutes [Regulatory functions, Protein interactions, Cellular processes, Sporulation and germination]


Pssm-ID: 131932  Cd Length: 106  Bit Score: 60.35  E-value: 3.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810    1 MNMSVKehqiDQKTKISVSGEIDVYSAPQLRETL--MPKAEAGEHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKL 78
Cdd:TIGR02886   1 IEFEVK----GDVLIVRLSGELDHHTAERVRRKIddAIERRPIKHLILNLKNVTFMDSSGLGVILGRYKKIKNEGGEVIV 76

                          90       100
                  ....*....|....*....|..
gi 515927810   79 ENLSERLVRLFEITGLKDIIDI 100
Cdd:TIGR02886  77 CNVSPAVKRLFELSGLFKIIRI 98
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
 26-99 4.58e-09

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 52.03  E-value: 4.58e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515927810  26 SAPQLRETLMPKAEAGEHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLENLSERLVRLFEITGLKDIID 99
Cdd:COG0659  436 NAERLKERLDALAPDPRVVILDLSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLERAGLLDELG 509
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
 26-99 3.71e-07

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 44.54  E-value: 3.71e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515927810  26 SAPQLRETLMPKAEAGEHLE---ICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLENLSERLVRLFEITGLKDIID 99
Cdd:cd07042   23 NAEYFKDRLLRLVDEDPPLKvviLDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQVRELLERAGLLDEIG 99
STAS cd06844
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of ...
 16-94 1.68e-05

Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain is found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors, like anti-anti-sigma factors and "stressosome" components. The sigma factor regulators are involved in protein-protein interaction which is regulated by phosphorylation.


Pssm-ID: 132911 [Multi-domain]  Cd Length: 100  Bit Score: 40.16  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515927810  16 ISVSGEIDVYSAPQLRETLMPKAE--AGEHLEICLKDVTYMDSTGLGVFVGLFKAAQKAGGTLKLENLSERLVRLFEITG 93
Cdd:cd06844   12 VRLEGELDHHSVEQFKEELLHNITnvAGKTIVIDISALEFMDSSGTGVLLERSRLAEAVGGQFVLTGISPAVRITLTESG 91


                 .
gi 515927810  94 L 94
Cdd:cd06844   92 L 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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