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Conserved domains on  [gi|515928745|ref|WP_017359328|]
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MULTISPECIES: tRNA1(Val) (adenine(37)-N6)-methyltransferase [Bacillus]

Protein Classification

tRNA1(Val) (adenine(37)-N6)-methyltransferase( domain architecture ID 11467886)

tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase is a class I SAM-dependent methyltransferase that specifically methylates the adenine in position 37 of tRNA(1)(Val)

CATH:  2.20.25.110
EC:  2.1.1.223
Gene Ontology:  GO:0016430|GO:1904047|GO:0008170|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 8-246 5.24e-115

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 329.03  E-value: 5.24e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745   8 ERLDYLLAEDMKIIQSKTVFAFSLDAVLLAKFAYVPiQKGEIIDLCTGNGIVPLLLSTRS-KASITGVEIQERLFDMAKR 86
Cdd:COG4123    1 ERLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVK-KGGRVLDLGTGTGVIALMLAQRSpGARITGVEIQPEAAELARR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  87 SVAHNQLEQQIELIHGDLNDMPKRYGNHKVDVITCNPPYFKtPSKDEINENEYLAIARHEIHCTLEDVIRVSSTLLKQGG 166
Cdd:COG4123   80 NVALNGLEDRITVIHGDLKEFAAELPPGSFDLVVSNPPYFK-AGSGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745 167 KLAMVHRPGRLLEIVEMMKKYRIEPKRIQFVYPKQGKEANTILVEGMKDGKPDLKILPPLFVYGEDQEYTKEIRTILYGE 246
Cdd:COG4123  159 RFALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRILPPLVIHDEDGEYTPEVKALLRDF 238
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 8-246 5.24e-115

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 329.03  E-value: 5.24e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745   8 ERLDYLLAEDMKIIQSKTVFAFSLDAVLLAKFAYVPiQKGEIIDLCTGNGIVPLLLSTRS-KASITGVEIQERLFDMAKR 86
Cdd:COG4123    1 ERLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVK-KGGRVLDLGTGTGVIALMLAQRSpGARITGVEIQPEAAELARR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  87 SVAHNQLEQQIELIHGDLNDMPKRYGNHKVDVITCNPPYFKtPSKDEINENEYLAIARHEIHCTLEDVIRVSSTLLKQGG 166
Cdd:COG4123   80 NVALNGLEDRITVIHGDLKEFAAELPPGSFDLVVSNPPYFK-AGSGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745 167 KLAMVHRPGRLLEIVEMMKKYRIEPKRIQFVYPKQGKEANTILVEGMKDGKPDLKILPPLFVYGEDQEYTKEIRTILYGE 246
Cdd:COG4123  159 RFALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRILPPLVIHDEDGEYTPEVKALLRDF 238
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 49-171 8.31e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 8.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  49 IIDLCTGNGIVPLLLSTRSKASITGVEIQERLFDMAKRSVAHNqLEQQIELIHGDLNDMPKrYGNHKVDVITCNPPYFKT 128
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAAL-LADNVEVLKGDAEELPP-EADESFDVIISDPPLHHL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 515928745 129 PskdeineneylaiarHEIHCTLEDVIRVsstlLKQGGKLAMV 171
Cdd:cd02440   80 V---------------EDLARFLEEARRL----LKPGGVLVLT 103
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 34-170 1.07e-11

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 62.87  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  34 VLLAKFAYVPIQKGEIIDLCTGNGIVPL-LLSTRSKASITGVEIQERLFDMAKRSVAHNqLEQQIELIHGDLNDmpkRYG 112
Cdd:PRK09328  97 VEWALEALLLKEPLRVLDLGTGSGAIALaLAKERPDAEVTAVDISPEALAVARRNAKHG-LGARVEFLQGDWFE---PLP 172

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515928745 113 NHKVDVITCNPPYfktpskdeINENEYLAIAR----HEIHCTL---ED-------VIRVSSTLLKQGGKLAM 170
Cdd:PRK09328 173 GGRFDLIVSNPPY--------IPEADIHLLQPevrdHEPHLALfggEDgldfyrrIIEQAPRYLKPGGWLLL 236
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 49-122 6.24e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 54.88  E-value: 6.24e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515928745   49 IIDLCTGNGIVPLLLSTRSKASITGVEIQERLFDMAKRSVAHNQLeqQIELIHGDLNDMPkrYGNHKVDVITCN 122
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLP--FPDGSFDLVVSS 70
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 8-246 5.24e-115

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 329.03  E-value: 5.24e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745   8 ERLDYLLAEDMKIIQSKTVFAFSLDAVLLAKFAYVPiQKGEIIDLCTGNGIVPLLLSTRS-KASITGVEIQERLFDMAKR 86
Cdd:COG4123    1 ERLDGFLFKQFRIIQPRCGYRFGTDAVLLAAFAPVK-KGGRVLDLGTGTGVIALMLAQRSpGARITGVEIQPEAAELARR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  87 SVAHNQLEQQIELIHGDLNDMPKRYGNHKVDVITCNPPYFKtPSKDEINENEYLAIARHEIHCTLEDVIRVSSTLLKQGG 166
Cdd:COG4123   80 NVALNGLEDRITVIHGDLKEFAAELPPGSFDLVVSNPPYFK-AGSGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745 167 KLAMVHRPGRLLEIVEMMKKYRIEPKRIQFVYPKQGKEANTILVEGMKDGKPDLKILPPLFVYGEDQEYTKEIRTILYGE 246
Cdd:COG4123  159 RFALIHPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRILPPLVIHDEDGEYTPEVKALLRDF 238
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 49-187 1.52e-15

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 74.03  E-value: 1.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  49 IIDLCTGNGIVPL-LLSTRSKASITGVEIQERLFDMAKRSVAHNQLEQQIELIHGDL-NDMPkryGNHKVDVITCNPPYf 126
Cdd:COG2890  116 VLDLGTGSGAIALaLAKERPDARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLfEPLP---GDGRFDLIVSNPPY- 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745 127 ktpskdeINENEY----------------------LAIARHeihctledVIRVSSTLLKQGGKLAMVHRPGRLLEIVEMM 184
Cdd:COG2890  192 -------IPEDEIallppevrdheprlaldggedgLDFYRR--------IIAQAPRLLKPGGWLLLEIGEDQGEAVRALL 256


                 ...
gi 515928745 185 KKY 187
Cdd:COG2890  257 EAA 259
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 49-171 8.31e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 8.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  49 IIDLCTGNGIVPLLLSTRSKASITGVEIQERLFDMAKRSVAHNqLEQQIELIHGDLNDMPKrYGNHKVDVITCNPPYFKT 128
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAAL-LADNVEVLKGDAEELPP-EADESFDVIISDPPLHHL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 515928745 129 PskdeineneylaiarHEIHCTLEDVIRVsstlLKQGGKLAMV 171
Cdd:cd02440   80 V---------------EDLARFLEEARRL----LKPGGVLVLT 103
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 34-170 1.07e-11

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 62.87  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  34 VLLAKFAYVPIQKGEIIDLCTGNGIVPL-LLSTRSKASITGVEIQERLFDMAKRSVAHNqLEQQIELIHGDLNDmpkRYG 112
Cdd:PRK09328  97 VEWALEALLLKEPLRVLDLGTGSGAIALaLAKERPDAEVTAVDISPEALAVARRNAKHG-LGARVEFLQGDWFE---PLP 172

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515928745 113 NHKVDVITCNPPYfktpskdeINENEYLAIAR----HEIHCTL---ED-------VIRVSSTLLKQGGKLAM 170
Cdd:PRK09328 173 GGRFDLIVSNPPY--------IPEADIHLLQPevrdHEPHLALfggEDgldfyrrIIEQAPRYLKPGGWLLL 236
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 49-122 6.24e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 54.88  E-value: 6.24e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515928745   49 IIDLCTGNGIVPLLLSTRSKASITGVEIQERLFDMAKRSVAHNQLeqQIELIHGDLNDMPkrYGNHKVDVITCN 122
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLP--FPDGSFDLVVSS 70
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 26-171 1.12e-08

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 53.27  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  26 VFAF-SLD---AVLLAKFAyvPIQKGEIIDLCTGNGIVPLLLSTRS-KASITGVEIQERLFDMAKRSVAHNQLEQqIELI 100
Cdd:COG2813   28 VFSRdRLDigtRLLLEHLP--EPLGGRVLDLGCGYGVIGLALAKRNpEARVTLVDVNARAVELARANAAANGLEN-VEVL 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515928745 101 HGDLNDmpkRYGNHKVDVITCNPPYF--KTPSKDEIneneylaiarHEIhctledvIRVSSTLLKQGGKLAMV 171
Cdd:COG2813  105 WSDGLS---GVPDGSFDLILSNPPFHagRAVDKEVA----------HAL-------IADAARHLRPGGELWLV 157
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-189 1.20e-07

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 49.90  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745   46 KGEIIDLCTGNGIVPLLLSTRS-KASITGVEIQERLFDMAKRSVAHNQLEQqIELIHGDLND--MPKRYgnhkvDVITCN 122
Cdd:pfam05175  32 SGKVLDLGCGAGVLGAALAKESpDAELTMVDINARALESARENLAANGLEN-GEVVASDVYSgvEDGKF-----DLIISN 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515928745  123 PPyFKTPSKDEineneyLAIArHEIhctledvIRVSSTLLKQGGKLAMV---HRPGRLL--------EIVEMMKKYRI 189
Cdd:pfam05175 106 PP-FHAGLATT------YNVA-QRF-------IADAKRHLRPGGELWIVanrFLGYPPLleelfgnvEVVAKTNGFKV 168
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 49-197 1.75e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 49.56  E-value: 1.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  49 IIDLCTGNGIVpLLLSTRSKASITGVEIQERLFDMAKRSVAHNQLEQqIELIHGDLNDMPKRygNHKVDVITCNPPYfkt 128
Cdd:COG1041   30 VLDPFCGTGTI-LIEAGLLGRRVIGSDIDPKMVEGARENLEHYGYED-ADVIRGDARDLPLA--DESVDAIVTDPPY--- 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515928745 129 pskdeineNEYLAIARHEIHCTLEDVIRVSSTLLKQGGKLAMV-HRPgrlleIVEMMKK--YRIEPKRIQFV 197
Cdd:COG1041  103 --------GRSSKISGEELLELYEKALEEAARVLKPGGRVVIVtPRD-----IDELLEEagFKVLERHEQRV 161
PRK14968 PRK14968
putative methyltransferase; Provisional
 32-141 1.07e-06

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 47.59  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  32 DAVLLAKFAYVpiQKGE-IIDLCTGNGIVPLLLSTRSKaSITGVEIQERLFDMAKRSVAHNQL-EQQIELIHGDLNDmpk 109
Cdd:PRK14968  11 DSFLLAENAVD--KKGDrVLEVGTGSGIVAIVAAKNGK-KVVGVDINPYAVECAKCNAKLNNIrNNGVEVIRSDLFE--- 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 515928745 110 RYGNHKVDVITCNPPYFKTPSKDEINENEYLA 141
Cdd:PRK14968  85 PFRGDKFDVILFNPPYLPTEEEEEWDDWLNYA 116
PRK14967 PRK14967
putative methyltransferase; Provisional
 48-130 7.08e-06

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 45.81  E-value: 7.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  48 EIIDLCTGNGIVPLLLSTRSKASITGVEIQERlfdmAKRSVAHNQLEQ--QIELIHGDLNDMpkrYGNHKVDVITCNPPY 125
Cdd:PRK14967  39 RVLDLCTGSGALAVAAAAAGAGSVTAVDISRR----AVRSARLNALLAgvDVDVRRGDWARA---VEFRPFDVVVSNPPY 111


                 ....*
gi 515928745 126 FKTPS 130
Cdd:PRK14967 112 VPAPP 116
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
49-121 2.28e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 44.26  E-value: 2.28e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515928745  49 IIDLCTGNGIVPLLLSTRSKASITGVEIQERLFDMAKRSVAHNQLEQQIELIHGDLNDM-PKRygnhKVDVITC 121
Cdd:COG4076   39 VLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLdLPE----KADVIIS 108
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 44-170 1.29e-04

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 42.54  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  44 IQKGEIIDLCTGNGIVPL-LLSTRSKASITGVEIQERLFDMAKRSVAHNQLEQQIELIHGDLNDmpkRYGNHKVDVITCN 122
Cdd:PRK01544 137 DKFLNILELGTGSGCIAIsLLCELPNANVIATDISLDAIEVAKSNAIKYEVTDRIQIIHSNWFE---NIEKQKFDFIVSN 213

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 515928745 123 PPYFKTPSKDE-----INENEYLAIARHEIHCTLEDVI-RVSSTLLKQGGKLAM 170
Cdd:PRK01544 214 PPYISHSEKSEmaietINYEPSIALFAEEDGLQAYFIIaENAKQFLKPNGKIIL 267
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 58-144 1.50e-04

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 41.19  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745   58 IVPLLLSTRSKASITGVEIQERLFDMAKRSVAHNQLEQQIELIHGDLNDMPKRygNHKVDVITCNPPYFKTPSKDEINEN 137
Cdd:pfam01170  53 IAPGKFDARVRAPLYGSDIDRRMVQGARLNAENAGVGDLIEFVQADAADLPLL--EGSVDVIVTNPPYGIRLGSKGALEA 130


                  ....*..
gi 515928745  138 EYLAIAR 144
Cdd:pfam01170 131 LYPEFLR 137
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 49-179 4.77e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 39.32  E-value: 4.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745   49 IIDLCTGNGIVPLLLSTR--SKASITGVEIQERLFDMAKRSVAHNQLEQqIELIHGDLNDMPKRYGNHKVDVITCNPPYF 126
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEElgPNAEVVGIDISEEAIEKARENAQKLGFDN-VEFEQGDIEELPELLEDDKFDVVISNCVLN 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515928745  127 KTPSKDEI--------NENEYLAIARHEIHCTLEDVIRVSSTLLK-QGGKLAMVHRPGRLLE 179
Cdd:pfam13847  86 HIPDPDKVlqeilrvlKPGGRLIISDPDSLAELPAHVKEDSTYYAgCVGGAILKKKLYELLE 147
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
33-124 6.89e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 39.50  E-value: 6.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  33 AVLLAKFAYVP--IQKGEIIDLCTGNGIVPLLLSTRSKASITGVEIQERLFDMAKRSVahNQLEQQIELIHGDLNDMPkr 110
Cdd:COG2263   31 AAELLHLAYLRgdIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIARENA--ERLGVRVDFIRADVTRIP-- 106

                         90
                 ....*....|....
gi 515928745 111 yGNHKVDVITCNPP 124
Cdd:COG2263  107 -LGGSVDTVVMNPP 119
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 49-120 8.23e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 39.75  E-value: 8.23e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515928745  49 IIDLCTGNGIVPLLLSTRS--KASITGVEIQERLFDMAKRSVAHNQLEQQIELIHGDLNDMPkrYGNHKVDVIT 120
Cdd:PRK00216  55 VLDLACGTGDLAIALAKAVgkTGEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEALP--FPDNSFDAVT 126
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
44-172 1.07e-03

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 39.40  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  44 IQKGE-IIDLCTGNG---------IVPLLLSTRSKASITGVEIQERLFDMAKRSVA-HNQLEQQIEliHGD--LNDMPKr 110
Cdd:COG0286   41 PKPGEtVYDPACGSGgflveaaeyLKEHGGDERKKLSLYGQEINPTTYRLAKMNLLlHGIGDPNIE--LGDtlSNDGDE- 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515928745 111 ygNHKVDVITCNPPyFKTPSKDEINENEYLAIARHEIHctledviRVSST----------LLKQGGKLAMVH 172
Cdd:COG0286  118 --LEKFDVVLANPP-FGGKWKKEELKDDLLGRFGYGLP-------PKSNAdllflqhilsLLKPGGRAAVVL 179
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 33-185 1.16e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 38.74  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  33 AVLLAKFAYVPiQKGEIIDLCTGNGIVPLLLSTRSKASITGVEIQERLFDMAKRSVAHNQLeQQIELIHGDLNDmPKRYG 112
Cdd:COG0500   15 AALLALLERLP-KGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLAE-LDPLP 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515928745 113 NHKVDVItcnppyfktpskdeineneylaIARHEIHCT----LEDVIRVSSTLLKQGGKLAMV-HRPGRLLEIVEMMK 185
Cdd:COG0500   92 AESFDLV----------------------VAFGVLHHLppeeREALLRELARALKPGGVLLLSaSDAAAALSLARLLL 147
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 30-121 1.18e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 38.37  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  30 SLDAVLLAKFAYV----PIQKGE-IIDLCTGNGIVPLLLSTRSKASITGVEIQERLFDMAKRSVAHNQLEQQIELIHGDL 104
Cdd:COG2230   31 TLEEAQEAKLDLIlrklGLKPGMrVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADY 110

                         90
                 ....*....|....*..
gi 515928745 105 NDMPkryGNHKVDVITC 121
Cdd:COG2230  111 RDLP---ADGQFDAIVS 124
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 37-131 1.53e-03

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 39.29  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  37 AKFAYVPiQKGEIIDLCTGNGIVPLLLS-TRSKASITGVEIQERLFDMAKRSVAhnQLEQQIELIHGDL--NDMPKRygn 113
Cdd:PRK14966 244 AVLARLP-ENGRVWDLGTGSGAVAVTVAlERPDAFVRASDISPPALETARKNAA--DLGARVEFAHGSWfdTDMPSE--- 317

                         90
                 ....*....|....*...
gi 515928745 114 HKVDVITCNPPYFKTPSK 131
Cdd:PRK14966 318 GKWDIIVSNPPYIENGDK 335
PHA03411 PHA03411
putative methyltransferase; Provisional
 47-139 3.10e-03

putative methyltransferase; Provisional


Pssm-ID: 177639 [Multi-domain]  Cd Length: 279  Bit Score: 38.16  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  47 GEIIDLCTGNGIVPLLLSTRSKAS-ITGVEIQERLFDMAKRsvahnqLEQQIELIHGDLNDMPKrygNHKVDVITCNPPY 125
Cdd:PHA03411  66 GKVLDLCAGIGRLSFCMLHRCKPEkIVCVELNPEFARIGKR------LLPEAEWITSDVFEFES---NEKFDVVISNPPF 136

                         90
                 ....*....|....
gi 515928745 126 FKTPSKDEINENEY 139
Cdd:PHA03411 137 GKINTTDTKDVFEY 150
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
8-122 6.41e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 36.51  E-value: 6.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745   8 ERLDYLLAEDMKIIQSKTVFAFSLDAVLLAKFAYVpiqkgeiIDLCTGNGIVPLLLSTRSKaSITGVEIQERLFDMAKRS 87
Cdd:COG4976   16 DSYDAALVEDLGYEAPALLAEELLARLPPGPFGRV-------LDLGCGTGLLGEALRPRGY-RLTGVDLSEEMLAKAREK 87

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 515928745  88 vahnqlEQQIELIHGDLNDMPkrYGNHKVDVITCN 122
Cdd:COG4976   88 ------GVYDRLLVADLADLA--EPDGRFDLIVAA 114
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
35-137 8.82e-03

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 36.85  E-value: 8.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515928745  35 LLAKFAYVpiQKGEIIDLC--TGNGIVPLLLSTRSKASITGVEIQERLFDMAkrSVAHNQLEQQIELIHGD-LNDMPkry 111
Cdd:COG0827  107 LVEKFTKK--EGLRILDPAvgTGNLLTTVLNQLKKKVNAYGVEVDDLLIRLA--AVLANLQGHPVELFHQDaLQPLL--- 179

                         90       100
                 ....*....|....*....|....*.
gi 515928745 112 gNHKVDVITCNPPYFKTPsKDEINEN 137
Cdd:COG0827  180 -IDPVDVVISDLPVGYYP-NDERAKR 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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