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Conserved domains on  [gi|515929459|ref|WP_017360042|]
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MULTISPECIES: low molecular weight protein arginine phosphatase [Bacillus]

Protein Classification

low molecular weight protein arginine phosphatase( domain architecture ID 11611418)

low molecular weight protein arginine phosphatase is a member of the low molecular weight phosphatase (LMWP) family, sharing a highly conserved active site motif (V/I)CXGNTCRS; it has been shown that the conserved threonine, which is an isoleucine in many LMWPTPs, confers specificity to phosphoarginine over phosphotyrosine; similar to Bacillus subtilis YwlE which catalyzes the specific dephosphorylation of phosphoarginine residues in a large number of proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 1-143 3.66e-79

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


:

Pssm-ID: 319972  Cd Length: 142  Bit Score: 230.40  E-value: 3.66e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   1 MNILFVCTGNTCRSPMAQALFSSIADEKGlqVTVKSAGIFASDAGKASPQAVEALFEKSIPL-NHSSSKLTEELLHEADY 79
Cdd:cd16344    1 MKILFVCTGNTCRSPMAEAILKKLLEELD--VEVKSAGIFAVDGSPASPNAVEVLKEKGIDLsGHRSQQLTEELLEWADL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515929459  80 VFTMTIQHKQLIVEQYAHVKDKVFTLKEFATGSEGDVSDPFGGSLSIYQETRDELETLLYQLAK 143
Cdd:cd16344   79 ILTMTESHKQALLSLYPEAADKVFTLKEYVGGEDGDISDPFGGSLEVYRQTAEELEELIEKLLK 142
 
Name Accession Description Interval E-value
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 1-143 3.66e-79

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 230.40  E-value: 3.66e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   1 MNILFVCTGNTCRSPMAQALFSSIADEKGlqVTVKSAGIFASDAGKASPQAVEALFEKSIPL-NHSSSKLTEELLHEADY 79
Cdd:cd16344    1 MKILFVCTGNTCRSPMAEAILKKLLEELD--VEVKSAGIFAVDGSPASPNAVEVLKEKGIDLsGHRSQQLTEELLEWADL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515929459  80 VFTMTIQHKQLIVEQYAHVKDKVFTLKEFATGSEGDVSDPFGGSLSIYQETRDELETLLYQLAK 143
Cdd:cd16344   79 ILTMTESHKQALLSLYPEAADKVFTLKEYVGGEDGDISDPFGGSLEVYRQTAEELEELIEKLLK 142
LMWPc smart00226
Low molecular weight phosphatase family;
3-143 4.01e-47

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 149.16  E-value: 4.01e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459     3 ILFVCTGNTCRSPMAQALFSSIAdekGLQVTVKSAGIFASDAGKASPQAVEALFEKSIPLNHSSSKLTEELLHEADYVFT 82
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYV---GDRVKIDSAGTGAWVGGGADPRAVKVLKEHGIDLSHHASQLTSSDFKNADLVLA 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515929459    83 MTIQHKQLIVEQYAHVKDKVFTLKEFAtgsegDVSDPFGGSLSIYQETRDELETLLYQLAK 143
Cdd:smart00226  78 MDGSHLRNICRLKPPSRAKVELFGHYV-----DVDDPYYGGIDGFERVYDELENALQEFLK 133
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
3-142 1.29e-42

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 137.89  E-value: 1.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459    3 ILFVCTGNTCRSPMAQALFSSIADEKGL--QVTVKSAGIFASDAGKASPQAVEALFEKSIPLN-HSSSKLTEELLHEADY 79
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLgdKVEVDSAGTGAWPGNPADPRAVEVLKEHGIDLSgHYARQLSTEDFASFDL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515929459   80 VFTMTIQHKQLIVEQY-AHVKDKVFTLKEFatGSEGDVSDPFGGSLSIYQETRDELETLLYQLA 142
Cdd:pfam01451  81 ILAMDSEHKRDLCPLApERYRAKVMLLGEY--GEQLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
1-147 4.37e-41

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 133.75  E-value: 4.37e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   1 MNILFVCTGNTCRSPMAQALFSSIADEKglqVTVKSAGIFAsdAGKASPQAVEALFEKSIPL-NHSSSKLTEELLHEADY 79
Cdd:COG0394    4 KRVLFVCTGNICRSPMAEALLRHLAGGR---VEVDSAGTEP--GGPVDPRAVAVLAERGIDLsGHRSRQLDEEDLPEFDL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515929459  80 VFTMTIQHKQLIVEQY-AHVKdkvfTLKEFatgsegDVSDPFGGSLSIYQETRDELETLLYQLAKKLKQ 147
Cdd:COG0394   79 VITMCDSAAEELCPLFpGAAK----LLLHW------DVPDPYYGGLEAFREVRDEIERRIEALLAKLRR 137
PRK13530 PRK13530
arsenate reductase (thioredoxin);
3-146 1.42e-13

arsenate reductase (thioredoxin);


Pssm-ID: 237415  Cd Length: 133  Bit Score: 63.23  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   3 ILFVCTGNTCRSPMAQALFSSIADEKGlqvTVKSAGIfasDAGKASPQAVEALFEKSIPL-NHSSSKLTEELLHEADYVF 81
Cdd:PRK13530   6 IYFLCTGNSCRSQMAEGWGKQYLGDKW---NVYSAGI---EAHGVNPNAIKAMKEVGIDIsNQTSDIIDNDILNNADLVV 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515929459  82 TMTiqhkqliveqyAHVKDKVFTLKEFATGSEGDVSDPFGGSLSIYQETRDELETLLYQLAKKLK 146
Cdd:PRK13530  80 TLC-----------SHADDVCPSTPPHVKRVHWGFDDPAGKEWSEFQRVRDEIGERIKRFAETGE 133
arsC_pI258_fam TIGR02691
arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent ...
 3-134 2.27e-12

arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent arsenate reductase of Staphylococcus aureaus plasmid pI258 and other mechanistically similar arsenate reductases. The mechanism involves an intramolecular disulfide bond cascade, and aligned members of this family have four absolutely conserved Cys residues. This group of arsenate reductases belongs to the low-molecular weight protein-tyrosine phosphatase family (pfam01451), as does a group of glutathione/glutaredoxin type arsenate reductases (TIGR02689). At least two other, non-homologous groups of arsenate reductases involved in arsenical resistance are also known. This enzyme reduces arsenate to arsenite, which may be more toxic but which is more easily exported. [Cellular processes, Detoxification]


Pssm-ID: 131738  Cd Length: 129  Bit Score: 60.18  E-value: 2.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459    3 ILFVCTGNTCRSPMAQALFSSIADEKglqVTVKSAGIfasDAGKASPQAVEALFEKSIPLNHSSSKLT-EELLHEADYVF 81
Cdd:TIGR02691   1 IYFLCTGNSCRSQMAEGWGKKYLGDE---WEVYSAGI---EAHGLNPNAVKAMKEVGIDISNQTSDLIdLDILNKADLVV 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 515929459   82 TMTIQHKQLIVEQYAHVKDKVFTLKEFAtGSEGDVSDpfggSLSIYQETRDEL 134
Cdd:TIGR02691  75 TLCGDARDKCPATPPHVKREHWGLDDPA-RAEGTEEE----KWAVFRRVRDEI 122
 
Name Accession Description Interval E-value
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 1-143 3.66e-79

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 230.40  E-value: 3.66e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   1 MNILFVCTGNTCRSPMAQALFSSIADEKGlqVTVKSAGIFASDAGKASPQAVEALFEKSIPL-NHSSSKLTEELLHEADY 79
Cdd:cd16344    1 MKILFVCTGNTCRSPMAEAILKKLLEELD--VEVKSAGIFAVDGSPASPNAVEVLKEKGIDLsGHRSQQLTEELLEWADL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515929459  80 VFTMTIQHKQLIVEQYAHVKDKVFTLKEFATGSEGDVSDPFGGSLSIYQETRDELETLLYQLAK 143
Cdd:cd16344   79 ILTMTESHKQALLSLYPEAADKVFTLKEYVGGEDGDISDPFGGSLEVYRQTAEELEELIEKLLK 142
LMWPc smart00226
Low molecular weight phosphatase family;
3-143 4.01e-47

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 149.16  E-value: 4.01e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459     3 ILFVCTGNTCRSPMAQALFSSIAdekGLQVTVKSAGIFASDAGKASPQAVEALFEKSIPLNHSSSKLTEELLHEADYVFT 82
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYV---GDRVKIDSAGTGAWVGGGADPRAVKVLKEHGIDLSHHASQLTSSDFKNADLVLA 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515929459    83 MTIQHKQLIVEQYAHVKDKVFTLKEFAtgsegDVSDPFGGSLSIYQETRDELETLLYQLAK 143
Cdd:smart00226  78 MDGSHLRNICRLKPPSRAKVELFGHYV-----DVDDPYYGGIDGFERVYDELENALQEFLK 133
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
3-142 1.29e-42

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 137.89  E-value: 1.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459    3 ILFVCTGNTCRSPMAQALFSSIADEKGL--QVTVKSAGIFASDAGKASPQAVEALFEKSIPLN-HSSSKLTEELLHEADY 79
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLgdKVEVDSAGTGAWPGNPADPRAVEVLKEHGIDLSgHYARQLSTEDFASFDL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515929459   80 VFTMTIQHKQLIVEQY-AHVKDKVFTLKEFatGSEGDVSDPFGGSLSIYQETRDELETLLYQLA 142
Cdd:pfam01451  81 ILAMDSEHKRDLCPLApERYRAKVMLLGEY--GEQLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
1-147 4.37e-41

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 133.75  E-value: 4.37e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   1 MNILFVCTGNTCRSPMAQALFSSIADEKglqVTVKSAGIFAsdAGKASPQAVEALFEKSIPL-NHSSSKLTEELLHEADY 79
Cdd:COG0394    4 KRVLFVCTGNICRSPMAEALLRHLAGGR---VEVDSAGTEP--GGPVDPRAVAVLAERGIDLsGHRSRQLDEEDLPEFDL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515929459  80 VFTMTIQHKQLIVEQY-AHVKdkvfTLKEFatgsegDVSDPFGGSLSIYQETRDELETLLYQLAKKLKQ 147
Cdd:COG0394   79 VITMCDSAAEELCPLFpGAAK----LLLHW------DVPDPYYGGLEAFREVRDEIERRIEALLAKLRR 137
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 3-143 1.82e-36

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 122.21  E-value: 1.82e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   3 ILFVCTGNTCRSPMAQALFSSiadEKGLQVTVKSAGIFASDAGKASPQAVEALFEKSIPLNHSSSKLTEELLHEADYVFT 82
Cdd:cd00115    2 ILFICTGNICRSPMAEAIFKQ---LLGDEWKVDSAGTGAHHGEGADPRAVRVLKEVGIDISHRSDQIKSEHLDNYDLVLV 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515929459  83 MTIQHKQLIVEQYAHVKDKvfTLKEFATGSEGDVSDPFGGSLSIYQETRDELETLLYQLAK 143
Cdd:cd00115   79 MDGSNLDKIPRIFPEARGK--TWLPHVKLEHGEIDDPYRGDIEDFRRVRDELENASKRFAE 137
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 1-135 2.64e-35

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 119.46  E-value: 2.64e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   1 MNILFVCTGNTCRSPMAQALFSSIADEKG-LQVTVKSAGIFASDAGK-ASPQAVEALFEKSIPLN-HSSSKLTEELLHEA 77
Cdd:cd16343    1 KKILFVCLGNICRSPMAEAVLRHLLPKAGgDDVEVDSAGTSAWHGGEpPDPRARAVLKEHGIDLSgHRARQLTAEDFDEF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515929459  78 DYVFTMTIQHKQLIVEQY-AHVKDKVFTLKEFATGSEGDVSDPFGGSLSIYQETRDELE 135
Cdd:cd16343   81 DLILAMDESNLRDLRRLApAEARGKVFLLGDFDPEGGKDVPDPYYGGREGFEEVYDLIE 139
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 2-83 8.30e-19

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 76.72  E-value: 8.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   2 NILFVCTGNTCRSPMAQALFSSIADEKglqVTVKSAGifaSDAGKASPQAVEALFEKSIPLNHSSSK-LTEELLHEADYV 80
Cdd:cd16345    1 KVLFLCTGNSARSQMAEALLRHLGGDR---FEAYSAG---SEPAGVNPLAIEVMKEIGIDISGQRSKsLDEFLGQEFDYV 74


                 ...
gi 515929459  81 FTM 83
Cdd:cd16345   75 ITV 77
COG4551 COG4551
Predicted protein tyrosine phosphatase [General function prediction only];
1-101 1.28e-13

Predicted protein tyrosine phosphatase [General function prediction only];


Pssm-ID: 443615  Cd Length: 109  Bit Score: 62.93  E-value: 1.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   1 MNILFVCTGNTCRSPMAQALFSSIADekglqVTVKSAGIfASDAGKaspqavealfeksiplnhsssKLTEELLHEADYV 80
Cdd:COG4551    2 MNVLFVCSRNRWRSPTAEQVFRNHPG-----VEVRSAGT-SPDARV---------------------PVTAELIEWADVI 54

                         90       100
                 ....*....|....*....|..
gi 515929459  81 FTMTIQHKQLIVEQYA-HVKDK 101
Cdd:COG4551   55 FVMEKKHRNRLSKRFGrLLKGK 76
PRK13530 PRK13530
arsenate reductase (thioredoxin);
3-146 1.42e-13

arsenate reductase (thioredoxin);


Pssm-ID: 237415  Cd Length: 133  Bit Score: 63.23  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   3 ILFVCTGNTCRSPMAQALFSSIADEKGlqvTVKSAGIfasDAGKASPQAVEALFEKSIPL-NHSSSKLTEELLHEADYVF 81
Cdd:PRK13530   6 IYFLCTGNSCRSQMAEGWGKQYLGDKW---NVYSAGI---EAHGVNPNAIKAMKEVGIDIsNQTSDIIDNDILNNADLVV 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515929459  82 TMTiqhkqliveqyAHVKDKVFTLKEFATGSEGDVSDPFGGSLSIYQETRDELETLLYQLAKKLK 146
Cdd:PRK13530  80 TLC-----------SHADDVCPSTPPHVKRVHWGFDDPAGKEWSEFQRVRDEIGERIKRFAETGE 133
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
2-147 3.43e-13

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 62.62  E-value: 3.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   2 NILFVCTGNTCRSPMAQALFSSIADEkglqVTVKSAGIFASDAGKASPQAVEALFEKSIPL-NHSSSKLTEELLHEADYV 80
Cdd:PRK10126   4 NILVVCVGNICRSPTAERLLQRYHPE----LKVESAGLGALVGKGADPTAISVAAEHQLSLeGHCARQISRRLCRNYDLI 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459  81 FTMTIQHKQLIVEQYAHVKDKVFTLKEFatGSEGDVSDPfggslsiYQETRDELE---TLLYQLAKKLKQ 147
Cdd:PRK10126  80 LTMEKRHIERLCEMAPEMRGKVMLFGHW--DNECEIPDP-------YRKSREAFEavyTLLERSARQWAQ 140
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 2-147 1.55e-12

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 61.19  E-value: 1.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459   2 NILFVCTGNTCRSPMAQALFSsiadEKGLQVTVKSAGIFASDAGKASPQAVEALFEKSIPLN-HSSSKLTEELLHEADYV 80
Cdd:PRK11391   4 SILVVCTGNICRSPIGERLLR----KRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEgHAGRKLTAEMARNYDLI 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515929459  81 FTMTIQHKQLIVEQYAHVKDKVFTLKEFATGSEgdVSDPFGGSLSIYQETRDELETLLYQLAKKLKQ 147
Cdd:PRK11391  80 LAMESEHIAQVTAIAPEVRGKTMLFGQWLEQKE--IPDPYRKSQDAFEHVYGMLERASQEWAKRLSR 144
arsC_pI258_fam TIGR02691
arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent ...
 3-134 2.27e-12

arsenate reductase (thioredoxin); This family describes the well-studied thioredoxin-dependent arsenate reductase of Staphylococcus aureaus plasmid pI258 and other mechanistically similar arsenate reductases. The mechanism involves an intramolecular disulfide bond cascade, and aligned members of this family have four absolutely conserved Cys residues. This group of arsenate reductases belongs to the low-molecular weight protein-tyrosine phosphatase family (pfam01451), as does a group of glutathione/glutaredoxin type arsenate reductases (TIGR02689). At least two other, non-homologous groups of arsenate reductases involved in arsenical resistance are also known. This enzyme reduces arsenate to arsenite, which may be more toxic but which is more easily exported. [Cellular processes, Detoxification]


Pssm-ID: 131738  Cd Length: 129  Bit Score: 60.18  E-value: 2.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459    3 ILFVCTGNTCRSPMAQALFSSIADEKglqVTVKSAGIfasDAGKASPQAVEALFEKSIPLNHSSSKLT-EELLHEADYVF 81
Cdd:TIGR02691   1 IYFLCTGNSCRSQMAEGWGKKYLGDE---WEVYSAGI---EAHGLNPNAVKAMKEVGIDISNQTSDLIdLDILNKADLVV 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 515929459   82 TMTIQHKQLIVEQYAHVKDKVFTLKEFAtGSEGDVSDpfggSLSIYQETRDEL 134
Cdd:TIGR02691  75 TLCGDARDKCPATPPHVKREHWGLDDPA-RAEGTEEE----KWAVFRRVRDEI 122
ars_reduc_gluta TIGR02689
arsenate reductase, glutathione/glutaredoxin type; Members of this protein family represent a ...
 3-135 1.81e-05

arsenate reductase, glutathione/glutaredoxin type; Members of this protein family represent a novel form of arsenate reductase, using glutathione and glutaredoxin rather than thioredoxin for reducing equivalents as do some homologous arsenate reductases. An example of this type is Synechocystis sp. strain PCC 6803 slr0946, and of latter type (excluded from this model) is Staphylococcus aureus plasmid pI258 ArsC. Both are among the subset of arsenate reductases that belong the the low-molecular-weight protein-tyrosine phosphatase superfamily. [Cellular processes, Detoxification]


Pssm-ID: 131736  Cd Length: 126  Bit Score: 41.81  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515929459    3 ILFVCTGNTCRSPMAQALFSSIADEKglqVTVKSAGIFASdagKASPQAVEALFEKSIPLNHSSSKLTEElLHEADYVFT 82
Cdd:TIGR02689   3 VMFVCKRNSCRSQMAEGFAKTLGAGK---IAVTSCGLESS---RVHPTAIAVMEEVGIDISGQTSKPLEN-FNAEDYDVV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 515929459   83 MTIQHKQLIVEQyAHVKDKVFtlkefatgSEGDVSDPFGGSLSIYQETRDELE 135
Cdd:TIGR02689  76 ISLCGCGVNLPE-AWVTREIF--------EDWQLEDPDGQSLEVFRRVRDEIK 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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