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Conserved domains on  [gi|515951694|ref|WP_017382277|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Enterobacter]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 18527488)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator containing a cupin-like domain, controls the expression of genes involved in stress response

Gene Ontology:  GO:0003677
PubMed:  10473770|15808743|10556324

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
6-75 4.74e-21

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 82.35  E-value: 4.74e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694   6 DNMNQRISARIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIARAE 75
Cdd:COG1396    2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGAD 71
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
91-184 7.00e-13

Uncharacterized conserved protein, cupin superfamily [Function unknown];


:

Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 62.34  E-value: 7.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694  91 RDPQTHYLRRHVSPRSDM-PIDLVQVELPAGSDVPMPASSYAlARQLIWLQAGELVFLEGDTRHEMKAGDCLELGPPNDC 169
Cdd:COG3837    8 PGPEAGRRYRRLGDALGLtRLGVNLITLPPGASSSPYHAHSA-EEEFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPH 86

                         90
                 ....*....|....*
gi 515951694 170 RFINETDESCLYLVV 184
Cdd:COG3837   87 RLRNRGDEPARYLVV 101
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
6-75 4.74e-21

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 82.35  E-value: 4.74e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694   6 DNMNQRISARIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIARAE 75
Cdd:COG1396    2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGAD 71
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 15-70 1.76e-15

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 67.19  E-value: 1.76e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 515951694  15 RIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTL 70
Cdd:cd00093    3 RLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
15-70 3.15e-15

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 66.77  E-value: 3.15e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 515951694    15 RIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTL 70
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 16-70 1.64e-13

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 62.17  E-value: 1.64e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 515951694   16 IRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTL 70
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
91-184 7.00e-13

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 62.34  E-value: 7.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694  91 RDPQTHYLRRHVSPRSDM-PIDLVQVELPAGSDVPMPASSYAlARQLIWLQAGELVFLEGDTRHEMKAGDCLELGPPNDC 169
Cdd:COG3837    8 PGPEAGRRYRRLGDALGLtRLGVNLITLPPGASSSPYHAHSA-EEEFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPH 86

                         90
                 ....*....|....*
gi 515951694 170 RFINETDESCLYLVV 184
Cdd:COG3837   87 RLRNRGDEPARYLVV 101
PHA01976 PHA01976
helix-turn-helix protein
 16-74 8.76e-07

helix-turn-helix protein


Pssm-ID: 177330 [Multi-domain]  Cd Length: 67  Bit Score: 44.56  E-value: 8.76e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515951694  16 IRLeRESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIARA 74
Cdd:PHA01976   8 IKA-RNARAWSAPELSRRAGVRHSLIYDFEADKRLPNLKTLLRLADALGVTLDWLCGRC 65
TIGR00270 TIGR00270
TIGR00270 family protein; [Hypothetical proteins, Conserved]
 16-67 1.57e-06

TIGR00270 family protein; [Hypothetical proteins, Conserved]


Pssm-ID: 129371 [Multi-domain]  Cd Length: 154  Bit Score: 46.06  E-value: 1.57e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 515951694   16 IRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISM 67
Cdd:TIGR00270  74 IRREREKRGWSQEQLAKKIQEKESLIKKIENAEIEPEPKVVEKLEKLLKIKL 125
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 115-184 1.25e-05

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 41.47  E-value: 1.25e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515951694  115 VELPAGSDVPMPASSYAlaRQLIWLQAGELVFLEGDTRHEMKAGDCLELgPPNDC-RFINETDESCLYLVV 184
Cdd:pfam07883   3 VTLPPGESSPPHRHPGE--DEFFYVLEGEGELTVDGEEVVLKAGDSVYF-PAGVPhRFRNTGDEPARLLDV 70
cupin_XRE_C cd02209
XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; ...
 97-184 1.33e-05

XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380339 [Multi-domain]  Cd Length: 90  Bit Score: 42.11  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694  97 YLRRHVSPR-SDMPIDLVQVELPAGSDVPmPASSYAlARQLIWLQAGELVFLEGDTRHEMKAGDCLELGPPNDCRFINET 175
Cdd:cd02209    2 YTYELLSPGlPGRKMEPFLVTLPPGGSGG-EPYSHE-GEEFGYVLEGELELTVGGETYVLEAGDSIYFDSDVPHRYRNPG 79


                 ....*....
gi 515951694 176 DESCLYLVV 184
Cdd:cd02209   80 DEPARVLWV 88
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
6-75 4.74e-21

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 82.35  E-value: 4.74e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694   6 DNMNQRISARIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIARAE 75
Cdd:COG1396    2 STLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGAD 71
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
8-75 5.98e-17

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 71.42  E-value: 5.98e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515951694   8 MNQRISARIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIARAE 75
Cdd:COG1476    1 MKKKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSLEE 68
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 4-68 8.69e-16

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 68.43  E-value: 8.69e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515951694   4 MTDNMNQRISA----RIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMS 68
Cdd:COG1813    1 MAKESTGELVEdygeRIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISLA 69
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 15-70 1.76e-15

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 67.19  E-value: 1.76e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 515951694  15 RIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTL 70
Cdd:cd00093    3 RLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
15-70 3.15e-15

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 66.77  E-value: 3.15e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 515951694    15 RIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTL 70
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 16-70 1.64e-13

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 62.17  E-value: 1.64e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 515951694   16 IRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTL 70
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
91-184 7.00e-13

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 62.34  E-value: 7.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694  91 RDPQTHYLRRHVSPRSDM-PIDLVQVELPAGSDVPMPASSYAlARQLIWLQAGELVFLEGDTRHEMKAGDCLELGPPNDC 169
Cdd:COG3837    8 PGPEAGRRYRRLGDALGLtRLGVNLITLPPGASSSPYHAHSA-EEEFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPH 86

                         90
                 ....*....|....*
gi 515951694 170 RFINETDESCLYLVV 184
Cdd:COG3837   87 RLRNRGDEPARYLVV 101
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 4-84 2.84e-12

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 60.03  E-value: 2.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694   4 MTDNMNQRISARIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIARaemQEGKLLR 83
Cdd:COG3620   10 VTVSPDDTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKIAEALGKELSAVLVV---DDGKLVG 86


                 .
gi 515951694  84 L 84
Cdd:COG3620   87 I 87
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 15-74 1.30e-11

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 57.30  E-value: 1.30e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694   15 RIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIARA 74
Cdd:pfam12844   3 RLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLLQGE 62
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 8-48 3.15e-08

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 48.65  E-value: 3.15e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 515951694   8 MNQRISARIRLERESRGWSLSELAERAGISRAMIHKIERGD 48
Cdd:COG1426    2 ALETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIEEGD 42
VapI COG3093
Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense ...
 21-87 5.05e-08

Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain [Defense mechanisms];


Pssm-ID: 442327 [Multi-domain]  Cd Length: 87  Bit Score: 48.27  E-value: 5.05e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515951694  21 ESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIAraeMQEGKLLRLANQ 87
Cdd:COG3093   19 EPLGLSQTELAKALGVSRQRISEILNGKRAITADTALRLARAFGTSAEFWLN---LQAAYDLWLARQ 82
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 11-66 4.66e-07

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 45.21  E-value: 4.66e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 515951694   11 RISARIRLERESRGWSLSELAERAGISRAMIHKIERG-DSSPTATLLARLSGAFGIS 66
Cdd:pfam13560   1 ELGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGrRGRPSPAVVERLARALGVD 57
COG1395 COG1395
Predicted transcriptional regulator [Transcription];
15-52 6.77e-07

Predicted transcriptional regulator [Transcription];


Pssm-ID: 441005 [Multi-domain]  Cd Length: 313  Bit Score: 48.29  E-value: 6.77e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 515951694  15 RIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPT 52
Cdd:COG1395  131 KLRELREERGLSLGELASELGVSRRTISKYERGEMDAS 168
PHA01976 PHA01976
helix-turn-helix protein
 16-74 8.76e-07

helix-turn-helix protein


Pssm-ID: 177330 [Multi-domain]  Cd Length: 67  Bit Score: 44.56  E-value: 8.76e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515951694  16 IRLeRESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIARA 74
Cdd:PHA01976   8 IKA-RNARAWSAPELSRRAGVRHSLIYDFEADKRLPNLKTLLRLADALGVTLDWLCGRC 65
PRK04140 PRK04140
transcriptional regulator;
15-59 1.44e-06

transcriptional regulator;


Pssm-ID: 235224 [Multi-domain]  Cd Length: 317  Bit Score: 47.16  E-value: 1.44e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 515951694  15 RIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARL 59
Cdd:PRK04140 130 VLREAREELGLSLGELASELGVSRRTISKYENGGMNASIEVAIKL 174
TIGR00270 TIGR00270
TIGR00270 family protein; [Hypothetical proteins, Conserved]
 16-67 1.57e-06

TIGR00270 family protein; [Hypothetical proteins, Conserved]


Pssm-ID: 129371 [Multi-domain]  Cd Length: 154  Bit Score: 46.06  E-value: 1.57e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 515951694   16 IRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISM 67
Cdd:TIGR00270  74 IRREREKRGWSQEQLAKKIQEKESLIKKIENAEIEPEPKVVEKLEKLLKIKL 125
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
105-184 6.18e-06

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 43.30  E-value: 6.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694 105 RSDMPIDLVQVELPAGSDVPMPassYALARQLIWLQAGELVFLEGDTRHEMKAGDCLELgPPNDC-RFINETDESCLYLV 183
Cdd:COG1917   18 DGEDELEVVRVTFEPGARTPWH---SHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFI-PPGVPhAFRNLGDEPAVLLV 93


                 .
gi 515951694 184 V 184
Cdd:COG1917   94 V 94
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 115-184 1.25e-05

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 41.47  E-value: 1.25e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515951694  115 VELPAGSDVPMPASSYAlaRQLIWLQAGELVFLEGDTRHEMKAGDCLELgPPNDC-RFINETDESCLYLVV 184
Cdd:pfam07883   3 VTLPPGESSPPHRHPGE--DEFFYVLEGEGELTVDGEEVVLKAGDSVYF-PAGVPhRFRNTGDEPARLLDV 70
cupin_XRE_C cd02209
XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; ...
 97-184 1.33e-05

XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380339 [Multi-domain]  Cd Length: 90  Bit Score: 42.11  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694  97 YLRRHVSPR-SDMPIDLVQVELPAGSDVPmPASSYAlARQLIWLQAGELVFLEGDTRHEMKAGDCLELGPPNDCRFINET 175
Cdd:cd02209    2 YTYELLSPGlPGRKMEPFLVTLPPGGSGG-EPYSHE-GEEFGYVLEGELELTVGGETYVLEAGDSIYFDSDVPHRYRNPG 79


                 ....*....
gi 515951694 176 DESCLYLVV 184
Cdd:cd02209   80 DEPARVLWV 88
PRK09943 PRK09943
HTH-type transcriptional regulator PuuR;
1-78 5.06e-05

HTH-type transcriptional regulator PuuR;


Pssm-ID: 182158 [Multi-domain]  Cd Length: 185  Bit Score: 42.09  E-value: 5.06e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515951694   1 MNTMTDNMNQRISARirleRESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIARAEMQE 78
Cdd:PRK09943   1 MSDEGLAPGKRLSEI----RQQQGLSQRRAAELSGLTHSAISTIEQDKVSPAISTLQKLLKVYGLSLSEFFSEPEKPD 74
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
23-71 6.80e-05

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 39.36  E-value: 6.80e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 515951694  23 RGWSLSELAERAGISRAMIHKIERGD-SSPTATLLARLSGAFGISMSTLI 71
Cdd:COG3655   13 RGMTKKELAEATGISRATLSRLKNGKaKAVRLDTLEKICKALDCQPGDLL 62
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 15-71 9.27e-05

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 39.06  E-value: 9.27e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 515951694   15 RIRLERESRGWSLSELAERAGISRAMIHKIERGDS-SPTATLLARLSGAFGISMSTLI 71
Cdd:pfam13443   1 KLRKLMADRGISKSDLARATGISRATLSRLRKGKPkRVSLDTLDKICDALGCQPGDLL 58
HTH_25 pfam13413
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 15-50 9.45e-05

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433187 [Multi-domain]  Cd Length: 62  Bit Score: 39.02  E-value: 9.45e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 515951694   15 RIRLERESRGWSLSELAERAGISRAMIHKIERGDSS 50
Cdd:pfam13413   1 RLRAAREARGLSLEDVAERTKIRPRYLEALEEDDFD 36
PRK09706 PRK09706
transcriptional repressor DicA; Reviewed
 9-98 9.55e-05

transcriptional repressor DicA; Reviewed


Pssm-ID: 182039 [Multi-domain]  Cd Length: 135  Bit Score: 40.61  E-value: 9.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694   9 NQRISARIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIARAEMQEGKLLRLANQP 88
Cdd:PRK09706   3 NLTLGQRIRYRRKQLKLSQRSLAKAVKVSHVSISQWERDETEPTGKNLFALAKALQCSPTWLLFGDEDKQPTPPVPLNQP 82

                         90
                 ....*....|
gi 515951694  89 VWRDPQTHYL 98
Cdd:PRK09706  83 VELSEDQKEL 92
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
14-59 2.53e-04

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 37.99  E-value: 2.53e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 515951694  14 ARIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARL 59
Cdd:COG2944    9 EEIRALRERLGLSQAEFAALLGVSVSTVRRWEQGRRKPSGAALKLL 54
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
18-129 4.45e-04

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 39.80  E-value: 4.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515951694  18 LERESRGWSLSELAERAGISRAMIHKI----------ERGDSSPTATL---LARLSGAFGISMSTL-IARAEMQEgkLLR 83
Cdd:COG1414   18 LAEAGGGLSLSELARRLGLPKSTVHRLlatleeegyvERDPEGGRYRLgprLLELGSAALRRLDLRrLARPVLEE--LAE 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 515951694  84 LANQP----VWRDPQTHYLRRHVSPRSdmpidlVQVELPAGSDVPMPASS 129
Cdd:COG1414   96 ETGETvhlaVLDGDEVVYVARVEGPRP------VRVSSRVGSRLPLHATA 139
antidote_HigA TIGR02607
addiction module antidote protein, HigA family; Members of this family form a distinct clade ...
 24-67 1.37e-03

addiction module antidote protein, HigA family; Members of this family form a distinct clade within the larger family HTH_3 of helix-turn-helix proteins, described by pfam01381. Members of this clade are strictly bacterial and nearly always shorter than 110 amino acids. This family includes the characterized member HigA, without which the killer protein HigB cannot be cloned. The hig (host inhibition of growth) system is noted to be unusual in that killer protein is uncoded by the upstream member of the gene pair. [Regulatory functions, DNA interactions, Regulatory functions, Protein interactions, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 274228 [Multi-domain]  Cd Length: 78  Bit Score: 36.06  E-value: 1.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 515951694   24 GWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISM 67
Cdd:TIGR02607  18 GLSVRALAKALGVSRSTLSRIVNGRAAITADMALRLAKALGTSP 61
PRK09726 PRK09726
type II toxin-antitoxin system antitoxin HipB;
1-73 1.75e-03

type II toxin-antitoxin system antitoxin HipB;


Pssm-ID: 182049  Cd Length: 88  Bit Score: 36.11  E-value: 1.75e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515951694   1 MNTMTDNMNQRISARIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIAR 73
Cdd:PRK09726   2 MSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAK 74
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 15-72 4.05e-03

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 36.86  E-value: 4.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 515951694  15 RIRLERESRGWSLSELAERAGISRAMIHKIERGDSSPTATLLARLSGAFGISMSTLIA 72
Cdd:PRK08154  32 RVRTLRARRGMSRKVLAQASGVSERYLAQLESGQGNVSILLLRRVARALGCSLADLLG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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