|
Name |
Accession |
Description |
Interval |
E-value |
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
1-430 |
0e+00 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 948.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 1 MLERLSWKRLVFELILCCIPALILGAIFGYLPWFLLVAVTGLLVWHFWNLLRLSWWLWVDRSMTPPPGSGSWEPLLYGLH 80
Cdd:PRK11006 1 MLERLSWKRLVLELALFCLPALILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLFYGLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 81 QMQMRNKKRRRELGSLIKRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPEFTLYLKKRD 160
Cdd:PRK11006 81 QMQLRNRKRRRELGNLIKRFRSGAESLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPEFTQYLKTRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 161 FSRPHNLKLNNGRHLEIRVMPYSDRQWLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPRE 240
Cdd:PRK11006 161 FSRPLTLVLNNGRHLEIRVMPYTEGQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALRE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 241 KALHTMREQTFRMEGLVKQLLTLSKIEAAPSLALNDIIDVPMMLRVVEREAQTLSHNQHTLSFDVDNTLKVLGSEDELRS 320
Cdd:PRK11006 241 KALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 321 AISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSH 400
Cdd:PRK11006 321 AISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSH 400
|
410 420 430
....*....|....*....|....*....|
gi 515952576 401 HESRLNIESTLGKGTRFSFVIPERLIAKKS 430
Cdd:PRK11006 401 HDSRLEIESEVGKGTRFSFVLPERLIAKNS 430
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
93-421 |
0e+00 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 519.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 93 LGSLIKRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPEFTLYLKKRDFSRP--HNLKLN 170
Cdd:TIGR02966 1 LSALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPEFVEYLAAGRFSEPleLPSPIN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 171 NGRHLEIRVMPYSDRQWLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQTLEGAP-REKALHTMREQ 249
Cdd:TIGR02966 81 SERVLEIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEeWNRALEIMLEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 250 TFRMEGLVKQLLTLSKIEAAPSLALNDIIDVPMMLRVVEREAQTLSHN-QHTLSFDVDNTLKVLGSEDELRSAISNLVYN 328
Cdd:TIGR02966 161 SQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGkNHQITFEIDGGVDVLGDEDELRSAFSNLVSN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 329 AVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIE 408
Cdd:TIGR02966 241 AIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIE 320
|
330
....*....|...
gi 515952576 409 STLGKGTRFSFVI 421
Cdd:TIGR02966 321 SELGKGSTFSFIF 333
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
75-422 |
2.77e-94 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 289.14 E-value: 2.77e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 75 LLYGLHQMQMRNKKRRRELGSLIKRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPEFTL 154
Cdd:COG5002 36 LLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 155 YLKKRDFSRPHNLKLNNGRHLEIRVMPYSDRQWLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQTL 234
Cdd:COG5002 116 ALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 235 EGAP-REKALHTMREQTFRMEGLVKQLLTLSKIEAAPSLALNDIIDVPMMLRVVEREAQTLSHN-QHTLSFDV-DNTLKV 311
Cdd:COG5002 196 DDPEeRREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEkGIELELDLpEDPLLV 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 312 LGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGL 391
Cdd:COG5002 276 LGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGL 355
|
330 340 350
....*....|....*....|....*....|.
gi 515952576 392 AIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:COG5002 356 AIVKHIVEAHGGRIWVESEPGKGTTFTITLP 386
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
173-422 |
1.14e-65 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 213.23 E-value: 1.14e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 173 RHLEIRVMPYSDRQWLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQTleGAPREKALHTMREQTFR 252
Cdd:COG0642 79 LLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQREYLETILRSADR 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 253 MEGLVKQLLTLSKIEAAPSLALNDIIDVPMMLR-VVEREAQTLSHNQHTLSFDVDNTL-KVLGSEDELRSAISNLVYNAV 330
Cdd:COG0642 157 LLRLINDLLDLSRLEAGKLELEPEPVDLAELLEeVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAI 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 331 NHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDkaRSRQTGGSGLGLAIVKHAVSHHESRLNIEST 410
Cdd:COG0642 237 KYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESE 314
|
250
....*....|..
gi 515952576 411 LGKGTRFSFVIP 422
Cdd:COG0642 315 PGKGTTFTVTLP 326
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
190-422 |
2.91e-65 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 208.99 E-value: 2.91e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 190 VARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQ-TLEGAPREKALHTMREQTFRMEGLVKQLLTLSKIEA 268
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEeDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 269 AP------SLALNDIIDvpmmlRVVEREAQTLSHNQHTLSFDVD-NTLKVLGSEDELRSAISNLVYNAVNHTPKGTHIAV 341
Cdd:COG2205 82 GKlslelePVDLAELLE-----EAVEELRPLAEEKGIRLELDLPpELPLVYADPELLEQVLANLLDNAIKYSPPGGTITI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 342 CWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDkaRSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVI 421
Cdd:COG2205 157 SARREGDGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
.
gi 515952576 422 P 422
Cdd:COG2205 235 P 235
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-425 |
7.76e-63 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 198.19 E-value: 7.76e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 318 LRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHA 397
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*...
gi 515952576 398 VSHHESRLNIESTLGKGTRFSFVIPERL 425
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPSSR 108
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
87-422 |
1.17e-54 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 187.09 E-value: 1.17e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 87 KKRRRELGSLIKRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLryPEFTLY-----LKKRDF 161
Cdd:COG5000 79 KEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELL--PELDLAellreALERGW 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 162 SRPHNLKLNNGRHLEIRVMPYSDRQWLMVARDVTQMHQLE-----G--ARRnffanVSHELRTPLTVLQGYLEMMQEQTL 234
Cdd:COG5000 157 QEEIELTRDGRRTLLVRASPLRDDGYVIVFDDITELLRAErlaawGelARR-----IAHEIKNPLTPIQLSAERLRRKLA 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 235 EGAP-----REKALHTMREQTFRMEGLVKQLLTLSKIEAaPSLA---LNDIIDvpmmlRVVEREAQTLSHNQHTLSFDVD 306
Cdd:COG5000 232 DKLEedredLERALDTIIRQVDRLKRIVDEFLDFARLPE-PQLEpvdLNELLR-----EVLALYEPALKEKDIRLELDLD 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 307 NTL-KVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYrvdkarSRQTG 385
Cdd:COG5000 306 PDLpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPK 379
|
330 340 350
....*....|....*....|....*....|....*..
gi 515952576 386 GSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:COG5000 380 GTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
109-422 |
1.36e-50 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 179.95 E-value: 1.36e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 109 DAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYP-EFTLylkkRD-FSRPHNLKL---NNGRHLEIRV--MP 181
Cdd:NF033092 269 DGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEeEYTL----RDlLEEQDSLLLdfsTEEEPLILRAnfSV 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 182 YSDRQWLM-----VARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLE-----MMQEQTLegAPRekALHTMREQTF 251
Cdd:NF033092 345 IQRESGFIngliaVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEaladgAWKDPEL--APR--FLGVTQNETE 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 252 RMEGLVKQLLTLSKIEAApSLALN-DIIDVPMML-RVVEREAQTLSHNQHTLSFDVDN-TLKVLGSEDELRSAISNLVYN 328
Cdd:NF033092 421 RMIRLVNDLLQLSRMDSK-DYKLNkEWVNFNEFFnYIIDRFEMILKNKNITFKREFPKrDLWVEIDTDKITQVLDNIISN 499
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 329 AVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIE 408
Cdd:NF033092 500 AIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAE 579
|
330
....*....|....
gi 515952576 409 STLGKGTRFSFVIP 422
Cdd:NF033092 580 SEEGKGTTIYFTLP 593
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
92-422 |
9.86e-49 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 169.64 E-value: 9.86e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 92 ELGSLIKRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPE-----FTLYLKKRDFSRPHN 166
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSplrelLERALAEGQPVTERE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 167 LKLNNG----RHLEIRVMPYSDRQ----WLMVARDVTQMHQLEGARR---------NFFANVSHELRTPLTVLQGYLEMM 229
Cdd:COG3852 81 VTLRRKdgeeRPVDVSVSPLRDAEgeggVLLVLRDITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGAAQLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 230 qEQTLEGAPREKALHTMREQTFRMEGLVKQLLTLSKIEAAP--SLALNDIIDVpmMLRVVEREAQtlshNQHTLSFDVDN 307
Cdd:COG3852 161 -ERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPErePVNLHEVLER--VLELLRAEAP----KNIRIVRDYDP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 308 TL-KVLGSEDELRSAISNLVYNAVNHTPKGTHI----AVCWQHTPAG------AEFSVEDNGPGIGPEHLPRLTERFYrv 376
Cdd:COG3852 234 SLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTItirtRVERQVTLGGlrprlyVRIEVIDNGPGIPEEILDRIFEPFF-- 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 515952576 377 dkarSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:COG3852 312 ----TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
82-425 |
4.17e-45 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 163.22 E-value: 4.17e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 82 MQMRN----KKRRRELGSLIKRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLR------------WPDDNGQNILN 145
Cdd:COG5809 121 AISRDiterKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISieeligksilelIHSDDQENVAA 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 146 LLRypEFTLYLKKRDFSRPHNLKLNNGRHLEIRVMP---YSDRQW-LMVARDVTQMHQLEGARRN---------FFANVS 212
Cdd:COG5809 201 FIS--QLLKDGGIAQGEVRFWTKDGRWRLLEASGAPikkNGEVDGiVIIFRDITERKKLEELLRKseklsvvgeLAAGIA 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 213 HELRTPLTVLQGYLEMMQEQTLEGapREKALHTMREQTFRMEGLVKQLLTLSKIEAA--PSLALNDIID--VPMMlrvve 288
Cdd:COG5809 279 HEIRNPLTSLKGFIQLLKDTIDEE--QKTYLDIMLSELDRIESIISEFLVLAKPQAIkyEPKDLNTLIEevIPLL----- 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 289 rEAQTLSHNQHTLSFDVDNTLKVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGA-EFSVEDNGPGIGPEHLP 367
Cdd:COG5809 352 -QPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKvVISVTDEGCGIPEERLK 430
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 515952576 368 RLTERFYrvdkarSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIPERL 425
Cdd:COG5809 431 KLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKL 482
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
209-422 |
2.04e-37 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 139.55 E-value: 2.04e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 209 ANVSHELRTPLTVLQGYLEMMQ---EQTLEGAPREKALHTMREQTFRMEGLVKQLLTLSKIEAAP--SLALNDIIDvpMM 283
Cdd:COG4191 147 AGIAHEINNPLAAILGNAELLRrrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEErePVDLNELID--EA 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 284 LRVVEREaqtLSHNQHTLSFDVDNTL-KVLGSEDELRSAISNLVYN---AVNHTPKGThIAVCWQHTPAGAEFSVEDNGP 359
Cdd:COG4191 225 LELLRPR---LKARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINaidAMEEGEGGR-ITISTRREGDYVVISVRDNGP 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515952576 360 GIGPEHLPRLTERFY---RVDKarsrqtgGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:COG4191 301 GIPPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
208-424 |
3.23e-36 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 139.15 E-value: 3.23e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 208 FAN-VSHELRTPLTVLQGYLEMMQEQtLEGAPREKA---LHTMREQTFRMEGLVKQLLTLSKIEAAP----SLALNDII- 278
Cdd:COG4251 285 FAYvASHDLREPLRKISGFSQLLEED-YGDKLDEEGreyLERIRDAAERMQALIDDLLAYSRVGRQElefePVDLNELLe 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 279 DVPMMLRVVEREAQTlshnqhtlSFDVDNTLKVLGSEDELRSAISNLVYNAVNHTPKGT--HIAVCWQHTPAGAEFSVED 356
Cdd:COG4251 364 EVLEDLEPRIEERGA--------EIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEppRIEIGAEREGGEWVFSVRD 435
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515952576 357 NGPGIGPEHLPRLTERFYRVDkaRSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIPER 424
Cdd:COG4251 436 NGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
313-424 |
3.89e-36 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 128.54 E-value: 3.89e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 313 GSEDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKaRSRQTGGSGLGLA 392
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 515952576 393 IVKHAVSHHESRLNIESTLGKGTRFSFVIPER 424
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
200-422 |
1.99e-35 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 135.98 E-value: 1.99e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 200 LEGARR---NFFANVSHELRTPLTVLqgyleMMQEQTLEGAPR-----EKALHTMREQTFRMEGLVKQLLTLSKIEAAPS 271
Cdd:TIGR01386 234 LEDAFQrlsQFSADLAHELRTPLTNL-----LGQTQVALSQPRtgeeyREVLESNLEELERLSRMVSDMLFLARADNGQL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 272 LALNDIIDVPMMLRVVEREAQTLSHNQhTLSFDVDNTLKVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAE 351
Cdd:TIGR01386 309 ALERVRLDLAAELAKVAEYFEPLAEER-GVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVR 387
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515952576 352 FSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKgTRFSFVIP 422
Cdd:TIGR01386 388 VSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
178-422 |
2.63e-34 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 133.03 E-value: 2.63e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 178 RVMPYSDRQWLMVARDVTQM----HQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPreKALHTMREQTFRM 253
Cdd:NF012163 210 RVTPTSNDELGKLAQDFNQLastlEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGIRKFTP--ESLDSLQAEVGTL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 254 EGLVKQLLTLSKIEA---APSLALNDIidVPMMLRVVEREAQTLSHNQHTLSFDVDNTLKVLGSEDELRSAISNLVYNAV 330
Cdd:NF012163 288 TKLVDDLHDLSMSDEgalAYQKASVDL--VPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSL 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 331 NHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIE-S 409
Cdd:NF012163 366 RYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAhS 445
|
250
....*....|...
gi 515952576 410 TLGkGTRFSFVIP 422
Cdd:NF012163 446 PLG-GLRIVVTLP 457
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
206-424 |
3.43e-34 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 132.97 E-value: 3.43e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 206 NFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPREKALHTMREQTFRMEGLVKQLLTLSKIEAA---PSLALNDIIDvpM 282
Cdd:PRK09835 264 NFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNqliPEKKMLDLAD--E 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 283 MLRVVEREAQTLSHNQHTLSFDVDNTLkVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIG 362
Cdd:PRK09835 342 VGKVFDFFEAWAEERGVELRFVGDPCQ-VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIA 420
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515952576 363 PEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIESTLgKGTRFSFVIPER 424
Cdd:PRK09835 421 PEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLPRL 481
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
318-421 |
5.87e-34 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 122.33 E-value: 5.87e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 318 LRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKarSRQTGGSGLGLAIVKHA 397
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 515952576 398 VSHHESRLNIESTLGKGTRFSFVI 421
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
86-422 |
9.47e-33 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 129.08 E-value: 9.47e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 86 NKKRRRELGSLIKRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYP---EFTLYLKKR--- 159
Cdd:COG5805 145 KKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCdkeEFKERIESItev 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 160 --DFSRPHNLKLNNGRH--LEIRVMPYSDR-----QWLMVARDVTQMHQLEGARRNF---------FANVSHELRTPLTV 221
Cdd:COG5805 225 wqEFIIEREIITKDGRIryFEAVIVPLIDTdgsvkGILVILRDITEKKEAEELMARSeklsiagqlAAGIAHEIRNPLTS 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 222 LQGYLEMMQEqTLEGapREKALHTMREQTFRMEGLVKQLLTLSKIEAA--PSLALNDII-DVPMMLrvverEAQTLSHNQ 298
Cdd:COG5805 305 IKGFLQLLQP-GIED--KEEYFDIMLSELDRIESIISEFLALAKPQAVnkEKENINELIqDVVTLL-----ETEAILHNI 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 299 HTLSFDVDNTLKVLGSEDELRSAISNLVYNAVNHTPKGTHIAVcwqHTPAGAEF---SVEDNGPGIGPEHLPRLTERFYr 375
Cdd:COG5805 377 QIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITI---HTEEEDNSviiRVIDEGIGIPEERLKKLGEPFF- 452
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 515952576 376 vdkarSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:COG5805 453 -----TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
190-422 |
1.24e-31 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 125.73 E-value: 1.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 190 VARDVTQM-HQLEGarRNFFANV----SHELRTPLTVLQGYLEMMQEQtLEGAPREKALHTMREQTFRMEGLVKQLLTLS 264
Cdd:PRK11100 239 LAQALESMrVKLEG--KAYVEQYvqtlTHELKSPLAAIRGAAELLQED-PPPEDRARFTGNILTQSARLQQLIDRLLELA 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 265 KIEAAPSLALNDIIDVPMMLR--VVEREAQtLSHNQHTLSFDVDNtLKVLGSEDELRSAISNLVYNAVNHTPKGTHIAVC 342
Cdd:PRK11100 316 RLEQRQELEVLEPVALAALLEelVEAREAQ-AAAKGITLRLRPDD-ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLS 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 343 WQHTPAGAEFSVEDNGPGIgPEH-LPRLTERFY---RVDKARSrqtgGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFS 418
Cdd:PRK11100 394 AEVDGEQVALSVEDQGPGI-PDYaLPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLAT 468
|
....
gi 515952576 419 FVIP 422
Cdd:PRK11100 469 LTLP 472
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
313-424 |
1.25e-30 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 113.62 E-value: 1.25e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 313 GSEDELRSAISNLVYNAVNHTPKGTHIAVCwQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKarsRQTGGSGLGLA 392
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|..
gi 515952576 393 IVKHAVSHHESRLNIESTLGKGTRFSFVIPER 424
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| PhoR |
pfam11808 |
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members ... |
7-90 |
1.35e-30 |
|
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members include PhoR. A member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR is the bifunctional histidine autokinase/phospho-PhoB phosphatase that donates a phosphoryl group to PhoB when environmental Pi is limiting and removes the phosphoryl group from phosphorylated PhoB (PhoB-P) when environmental Pi is abundant.
Pssm-ID: 432090 Cd Length: 84 Bit Score: 112.70 E-value: 1.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 7 WKRLVFELILCCIPALILGAIFGYLPWFLLVAVTGLLVWHFWNLLRLSWWLWVDRSMTPPPGSGSWEPLLYGLHQMQMRN 86
Cdd:pfam11808 1 WRRLLWRLALLLLPALLLGLLFGHLAAALLLALLAYLAWHLYQLLRLSRWLWRPRKLTPPDGSGLWGEIFYGLYRLQRRN 80
|
....
gi 515952576 87 KKRR 90
Cdd:pfam11808 81 RRRR 84
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
105-422 |
4.62e-30 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 122.38 E-value: 4.62e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 105 ESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPEftlylkkrDFSRPHNLKLNNGR-HLEIRV-MPY 182
Cdd:PRK11360 269 ESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFPPNT--------PFASPLLDTLEHGTeHVDLEIsFPG 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 183 SDRQW-------------------LMVARDVT-------QMHQLE--GARRNFFANVSHELRTPLTVLQGYLEMMQEQTl 234
Cdd:PRK11360 341 RDRTIelsvstsllhnthgemigaLVIFSDLTerkrlqrRVARQErlAALGELVAGVAHEIRNPLTAIRGYVQIWRQQT- 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 235 EGAPREKALHTMREQTFRMEGLVKQLLTLSKieaaPSLALNDIIDVPMMLRVVEREAQTLSH-NQHTLSFDVDNTL-KVL 312
Cdd:PRK11360 420 SDPPSQEYLSVVLREVDRLNKVIDQLLEFSR----PRESQWQPVSLNALVEEVLQLFQTAGVqARVDFETELDNELpPIW 495
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 313 GSEDELRSAISNLVYNAVNHTPKGTHIAV-CWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVdKARsrqtgGSGLGL 391
Cdd:PRK11360 496 ADPELLKQVLLNILINAVQAISARGKIRIrTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTT-KAK-----GTGLGL 569
|
330 340 350
....*....|....*....|....*....|.
gi 515952576 392 AIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:PRK11360 570 ALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
201-422 |
6.92e-27 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 112.03 E-value: 6.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 201 EGARRNFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPreKALHTMREQTFRMEGLVKQL--LTLSKIEAapsLAL-NDI 277
Cdd:PRK10549 237 EQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTP--ESVASLQAEVGTLTKLVDDLhqLSLSDEGA---LAYrKTP 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 278 IDVPMMLRVV-----EReaqtLSHNQHTLSFDVDNTLKVLGSEDELRSAISNLVYNAVNHTPKG--THIAVCWQHTPAGA 350
Cdd:PRK10549 312 VDLVPLLEVAggafrER----FASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGgsLHISAEQRDKTLRL 387
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515952576 351 EFsvEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIE-STLGkGTRFSFVIP 422
Cdd:PRK10549 388 TF--ADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITVELP 457
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
318-422 |
4.37e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 101.42 E-value: 4.37e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 318 LRSAISNLVYNAVNHTPKGTHIAVCW----QHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAI 393
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTLRVSleeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 515952576 394 VKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
205-425 |
5.50e-26 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 107.75 E-value: 5.50e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 205 RNFFANVSHELRTPLTVLQGYLEMMQEQ-TLEGAPREKALHtmreqtfRMEGLVKQLLTLSKIEAAPSLA-------LND 276
Cdd:PRK10755 138 RLFTADVAHELRTPLAGIRLHLELLEKQhHIDVAPLIARLD-------QMMHTVEQLLQLARAGQSFSSGhyqtvklLED 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 277 IIdVPMMLRVVEREAQtlsHNQHTLSFDVDNTLKVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVED 356
Cdd:PRK10755 211 VI-LPSQDELSEMLEQ---RQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVED 286
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 357 NGPGIGPEHLPRLTERFYRVDkarsRQTGGSGLGLAIVKHAVSHHESRLNIESTL-GKGTRFSFVIPERL 425
Cdd:PRK10755 287 EGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQFFLQNRQeRSGTRAWVWLPKAQ 352
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
209-422 |
8.27e-26 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 108.42 E-value: 8.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 209 ANVSHELRTPLTVLQGYLEMMQEQTLEGAPREKALHTMREQTFRMEGLVKQLLTLSKieaaPSLALNDIIDVPMMLRVVE 288
Cdd:COG5806 206 ASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAK----PQPEKLEKIDVSEELEHVI 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 289 REAQTLSHNQH-TLSFDVDNTLKVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLP 367
Cdd:COG5806 282 DVLSPYANMNNvEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLE 361
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 515952576 368 RLTERFYrvdkarSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:COG5806 362 RLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLP 410
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
4-422 |
2.74e-25 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 106.47 E-value: 2.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 4 RLSWKRLVFELILCCIPALILGAIFGYLPWFLLVAVTGLLVWHFWNLLRLSWWLWVDRSmtpppgsgswepLLYGLHQMQ 83
Cdd:COG3290 2 LLLLLLLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLIL------------LLLLLLLLA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 84 MRNKKRRRELGSLIKRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLrwpDDNGQNILNLLRYpeftlYLKKRDFSR 163
Cdd:COG3290 70 ALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLAE-----VLETGERDE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 164 PHNLklnNGRHLEIRVMPYSDRQ----WLMVARDVTQMH----QLEGARRnfFANV----SHELRTPLTVLQGYLEMMQE 231
Cdd:COG3290 142 EILL---NGRVLVVNRVPIRDDGrvvgAVATFRDRTELErleeELEGVKE--LAEAlraqRHDFRNHLHTISGLLQLGEY 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 232 qtlegaprEKALHTMREQTFRMEGLVKQLLTLSKieaapslalNDIIDVpmmlrVVEREAQTLSHNQHTLSFDVDNTLKV 311
Cdd:COG3290 217 --------DEALEYIDEISEELQELIDSLLSRIG---------NPVLAA-----LLLGKAARARERGIDLTIDIDSDLPD 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 312 LG-SEDELRSAISNLVYNAVNHTPKGT----HIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRvdkarSRQTGG 386
Cdd:COG3290 275 LPlSDTDLVTILGNLLDNAIEAVEKLPeeerRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS-----TKLGEG 349
|
410 420 430
....*....|....*....|....*....|....*.
gi 515952576 387 SGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:COG3290 350 RGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
192-424 |
1.82e-24 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 105.49 E-value: 1.82e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 192 RDVTQMHQLEGARRNFFANVSHELRTPLTVLQ--GYLEMMQEQTLEGAPREKAlHTMREQTFRMEGLVKQLLTLSKIEA- 268
Cdd:NF040691 259 RQIRQLEELSRLQQRFVSDVSHELRTPLTTIRmaADVIHDSRDDFDPATARSA-ELLHTELDRFESLLSDLLEISRFDAg 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 269 APSLALNDIIDVPMMLRVVEREAQTLSHNQHTLSFDVDNTlKVLGSEDELR--SAISNLVYNAVNHTpKGTHIAVcwqhT 346
Cdd:NF040691 338 AAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGT-PVVAEVDPRRveRVLRNLVVNAIEHG-EGKPVVV----T 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 347 PAGAE----FSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:NF040691 412 VAQDDtavaVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
..
gi 515952576 423 ER 424
Cdd:NF040691 492 RV 493
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
196-425 |
3.40e-24 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 103.91 E-value: 3.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 196 QMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQTlegAPREKALHtmREQTfRMEGLVKQLLTLSKIEAaPSLALN 275
Cdd:PRK10604 204 NINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLS---AAESQALN--RDIG-QLEALIEELLTYARLDR-PQNELH 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 276 -DIIDVPMMLRVVEREAQTLsHNQHTLSFDVDNTLKVLGSEDELRS-AISNLVYNAVNHTPKGTHIAVCWQHtpAGAEFS 353
Cdd:PRK10604 277 lSEPDLPAWLSTHLADIQAV-TPEKTVRLDTPHQGDYGALDMRLMErVLDNLLNNALRYAHSRVRVSLLLDG--NQACLI 353
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515952576 354 VEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIPERL 425
Cdd:PRK10604 354 VEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWH 425
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
308-416 |
6.27e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 95.94 E-value: 6.27e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 308 TLKVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCwQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKarsRQTGGS 387
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIK-LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGS 79
|
90 100
....*....|....*....|....*....
gi 515952576 388 GLGLAIVKHAVSHHESRLNIESTLGKGTR 416
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFLGNAQGGGLE 108
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-422 |
1.41e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 94.31 E-value: 1.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 318 LRSAISNLVYNAVNHTPKGTHIAvcWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHA 397
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLD--ISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 515952576 398 VSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
315-422 |
2.23e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 94.07 E-value: 2.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 315 EDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIV 394
Cdd:cd16946 2 RDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAIC 81
|
90 100
....*....|....*....|....*....
gi 515952576 395 KHAVSHHESRLNIE-STLGkGTRFSFVIP 422
Cdd:cd16946 82 HNIALAHGGTISAEhSPLG-GLRLVLTLP 109
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
205-405 |
2.79e-23 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 101.26 E-value: 2.79e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 205 RNFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPREKALHTMREQTFRMEGLVKQLLTLSKIEAapslaLNDIIDV-PMM 283
Cdd:PRK10337 238 RRFTSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDS-----LDNLQDVaEIP 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 284 LRVVEREAqTLSHNQHTLSFDVDNTLKVLGSEDE-------LRSAISNLVYNAVNHTPKGTHIAVcwqhTPAGAEFSVED 356
Cdd:PRK10337 313 LEDLLQSA-VMDIYHTAQQAGIDVRLTLNAHPVIrtgqpllLSLLVRNLLDNAIRYSPQGSVVDV----TLNARNFTVRD 387
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 515952576 357 NGPGIGPEHLPRLTERFYRvdkARSRQTGGSGLGLAIVKHAVSHHESRL 405
Cdd:PRK10337 388 NGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNV 433
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
192-401 |
5.47e-23 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 100.37 E-value: 5.47e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 192 RDVTQ--------MHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEqtlegaprekalhtmrEQTFRMEGLVKQlltl 263
Cdd:PRK09467 209 RSVTRafnqmaagIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMSE----------------EDGYLAESINKD---- 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 264 skIEAapslaLNDIIDVPM-MLRVVERE--------------AQTLSHNQHTLSFDV-DNTLKVLGSEDELRSAISNLVY 327
Cdd:PRK09467 269 --IEE-----CNAIIEQFIdYLRTGQEMpmemadlnallgevIAAESGYEREIETALqPGPIEVPMNPIAIKRALANLVV 341
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515952576 328 NAVNHtpkGTH-IAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSrqTGGSGLGLAIVKHAVSHH 401
Cdd:PRK09467 342 NAARY---GNGwIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQH 411
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
211-422 |
1.15e-21 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 96.92 E-value: 1.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 211 VSHELRTPLTVLQGYLEMMQEQTLEGapreKALHTMREQTFRMEGLVKQLLTLSKIEA----------APSLaLNDIIDV 280
Cdd:PRK09470 250 ISHELRTPLTRLQLATALLRRRQGES----KELERIETEAQRLDSMINDLLVLSRNQQknhleretfkANSL-WSEVLED 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 281 pmmlrvVEREAQtlsHNQHTLSFDVD-NTLKVLGSEDELRSAISNLVYNAVNHTpkGTHIAVCWQHTPAGAEFSVEDNGP 359
Cdd:PRK09470 325 ------AKFEAE---QMGKSLTVSAPpGPWPINGNPNALASALENIVRNALRYS--HTKIEVAFSVDKDGLTITVDDDGP 393
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515952576 360 GIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIE-STLGkGTRFSFVIP 422
Cdd:PRK09470 394 GVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEdSPLG-GLRLTIWLP 456
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-414 |
1.94e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 85.58 E-value: 1.94e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 318 LRSAISNLVYNAVNHTpkGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSrqTGGSGLGLAIVKHA 397
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90
....*....|....*..
gi 515952576 398 VSHHESRLNIESTLGKG 414
Cdd:cd16950 77 SDAHGGSLTLANRAGGG 93
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
198-422 |
8.44e-20 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 92.01 E-value: 8.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 198 HQLEGARR----------NFFANVSHELRTPLTVLQGYLEMMQEQTLEgAPREKALHTMREQTFRMEGLVKQLLTLSKIE 267
Cdd:PRK15347 382 QALAEAKQraeqankrksEHLTTISHEIRTPLNGVLGALELLQNTPLT-AEQMDLADTARQCTLSLLAIINNLLDFSRIE 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 268 AA------PSLALNDIIDVPMMlrVVEREAQTLSHNQHTL-SFDVDNTLKVLGSEdeLRSAISNLVYNAVNHTPKGtHIA 340
Cdd:PRK15347 461 SGqmtlslEETALLPLLDQAML--TIQGPAQSKSLTLRTFvGAHVPLYLHLDSLR--LRQILVNLLGNAVKFTETG-GIR 535
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 341 VCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKarsrQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFV 420
Cdd:PRK15347 536 LRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLV 611
|
..
gi 515952576 421 IP 422
Cdd:PRK15347 612 LP 613
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-422 |
1.81e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 83.15 E-value: 1.81e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 318 LRSAISNLVYNAVNHTPKGTH--IAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDkarSRQT-GGSGLGLAIV 394
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREEyEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 515952576 395 KHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
191-422 |
3.32e-19 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 90.22 E-value: 3.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 191 ARDVTQmhQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPReKALHTMREQTFRMEGLVKQLLTLSKIEAAp 270
Cdd:TIGR02956 453 ARAEAE--EANRAKSAFLATMSHEIRTPLNGILGTLELLGDTGLTSQQQ-QYLQVINRSGESLLDILNDILDYSKIEAG- 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 271 SLALNDI-IDVPMMLRVVEREAQTLSHNQH-TLSFDVDNTLK--VLGSEDELRSAISNLVYNAVNHTPKGT---HIAVCW 343
Cdd:TIGR02956 529 HLSISPRpFDLNALLDDVHHLMVSRAQLKGiQLRLNIPEQLPnwWQGDGPRIRQVLINLVGNAIKFTDRGSvvlRVSLND 608
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515952576 344 QHTPAgaeFSVEDNGPGIGPEHLPRLTERFYRVDKARSrqTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:TIGR02956 609 DSSLL---FEVEDTGCGIAEEEQATLFDAFTQADGRRR--SGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
316-422 |
1.05e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 81.00 E-value: 1.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 316 DELRSAISNLVYNAVNHTPKGTHIAVCWQHT-PAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIV 394
Cdd:cd16925 3 EKYERVVLNLLSNAFKFTPDGGRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIV 82
|
90 100
....*....|....*....|....*...
gi 515952576 395 KHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16925 83 KEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
187-430 |
1.82e-18 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 87.15 E-value: 1.82e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 187 WLMVARDVTQMHQLEGARR-------NFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPREKALHTMREQTFRMEGLVKQ 259
Cdd:PRK10364 213 WYRRYLRSRQLLQDEMKRKeklvalgHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSE 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 260 LLTLSKieaaPS------LALNDIIDvpMMLRVVEREAQTlshNQHTLSFDVDNTLKVLGSE-DELRSAISNLVYNAVNH 332
Cdd:PRK10364 293 LLELVK----PThlalqaVDLNDLIN--HSLQLVSQDANS---REIQLRFTANDTLPEIQADpDRLTQVLLNLYLNAIQA 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 333 TPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYrVDKARsrqtgGSGLGLAIVKHAVSHHESRLNIESTLG 412
Cdd:PRK10364 364 IGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYF-TTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEG 437
|
250
....*....|....*...
gi 515952576 413 KGTRFSFVIPERLIAKKS 430
Cdd:PRK10364 438 KGATFTLWLPVNITRRDP 455
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
203-431 |
1.88e-18 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 88.25 E-value: 1.88e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 203 ARRNFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPREKALHTMREQTFRMEGLVKQLLTLSKIEAAPSLALNDIIDVPM 282
Cdd:PRK09959 711 AKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 283 MLRVVEREAQTLSHNQhTLSFDVDNTLK----VLGSEDELRSAISNLVYNAVNHTPKG----THIAVCWQHTPAGAEFSV 354
Cdd:PRK09959 791 LVQNTCHSFGAIAASK-SIALSCSSTFPdhylVKIDPQAFKQVLSNLLSNALKFTTEGavkiTTSLGHIDDNHAVIKMTI 869
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515952576 355 EDNGPGIGPEHLPRLTERFYRVdkARSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIPERLIAKKSA 431
Cdd:PRK09959 870 MDSGSGLSQEEQQQLFKRYSQT--SAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEISQQVAT 944
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
209-422 |
4.01e-18 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 85.39 E-value: 4.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 209 ANVSHELRTPLT----VLQGyLEMMQEQT---LEGAPREKALHTMREQTFRMEGLVKQLLTLSKiEAAPSLALN-DIIDV 280
Cdd:PRK09303 156 AMLAHDLRTPLTaaslALET-LELGQIDEdteLKPALIEQLQDQARRQLEEIERLITDLLEVGR-TRWEALRFNpQKLDL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 281 -PMMLRVVEREAQTLSHNQHTLSFDVDNTL-KVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQH-TPAGAEFSVEDN 357
Cdd:PRK09303 234 gSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHrTTQKVQVSICDT 313
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515952576 358 GPGIGPEHLPRLTERFYRVDkaRSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:PRK09303 314 GPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
201-422 |
4.23e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 87.01 E-value: 4.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 201 EGARRNFFANVSHELRTPLTVLQGYLEM-MQEQTLEGAPREKALHTMREQTFRMEGLVKQLLTLSKIEA------APSLA 273
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEIlTLDLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSggfnlrKEWLT 740
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 274 LNDIidVPMMLRVVEreaQTLSHNQHTLSFDVDNTL-KVLGSEDElRSAIsNLVYNAVNHTPKGTHIAVCWQHTPAGAEF 352
Cdd:PRK10490 741 LEEV--VGSALQMLE---PGLSGHPINLSLPEPLTLiHVDGPLFE-RVLI-NLLENAVKYAGAQAEIGIDAHVEGERLQL 813
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 353 SVEDNGPGIGPEHLPRLTERFYRVDKARSrqTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:PRK10490 814 DVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
203-265 |
6.46e-18 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 77.25 E-value: 6.46e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515952576 203 ARRNFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPREKALHTMREQTFRMEGLVKQLLTLSK 265
Cdd:cd00082 3 AKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
182-422 |
7.54e-18 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 86.27 E-value: 7.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 182 YSDRQWLMVARDVTQmHQLEGARR-----NFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPREKALHTMREQTFRMEGL 256
Cdd:PRK13837 424 AIERRRLETERDALE-RRLEHARRleavgTLASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLI 502
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 257 VKQLLTLSKIEAAPS--LALNDIIDVPM-MLRVvereaqtlSHNQH-TLSFDVDNT-LKVLGSEDELRSAISNLVYNAV- 330
Cdd:PRK13837 503 IDQILAFGRKGERNTkpFDLSELVTEIApLLRV--------SLPPGvELDFDQDQEpAVVEGNPAELQQVLMNLCSNAAq 574
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 331 ----------------NHTPKG-THIAVcwqhtPAG--AEFSVEDNGPGIGPEHLPRLTERFYrvdKARSrqtGGSGLGL 391
Cdd:PRK13837 575 amdgagrvdislsrakLRAPKVlSHGVL-----PPGryVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGL 643
|
250 260 270
....*....|....*....|....*....|.
gi 515952576 392 AIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:PRK13837 644 ATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
203-268 |
2.49e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 75.71 E-value: 2.49e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515952576 203 ARRNFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPREkALHTMREQTFRMEGLVKQLLTLSKIEA 268
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQRE-YLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
176-428 |
2.78e-17 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 84.22 E-value: 2.78e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 176 EIRVMPYSD----RQWLM-VARDVTQ--MHQ--LEGARRN---FFANVSHELRTPLTVLQGYLEMMQEQTLEGaprekal 243
Cdd:PRK11091 243 ELRKVPFYDrvgkRHGLMgFGRDITErkRYQdaLEKASRDkttFISTISHELRTPLNGIVGLSRILLDTELTA------- 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 244 htmrEQTFRMEGLVKQLLTLSKIeaapslaLNDIIDVPMM-LRVVEREAQTLSHN---------------QHTLSFDVDN 307
Cdd:PRK11091 316 ----EQRKYLKTIHVSAITLGNI-------FNDIIDMDKMeRRKLQLDNQPIDFTdfladlenlsglqaeQKGLRFDLEP 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 308 TL----KVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRV-DKARSR 382
Cdd:PRK11091 385 LLplphKVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGK 464
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 515952576 383 QTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIPERLIAK 428
Cdd:PRK11091 465 PATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAE 510
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
203-268 |
3.46e-17 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 75.30 E-value: 3.46e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515952576 203 ARRNFFANVSHELRTPLTVLQGYLEMMQEQTLeGAPREKALHTMREQTFRMEGLVKQLLTLSKIEA 268
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTEL-SEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
209-422 |
3.50e-16 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 79.27 E-value: 3.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 209 ANVSHELRTPLTVLQGYLEMMQEQTLEgaPREKALHTMREQTFRMEGLVKQLLTLSKIEAA------PSLALNDIIDvpm 282
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDGVFE--PDPALFKSLLNQVEGLSHLVEDLRTLSLVENQqlrlnyESVDLKDSIE--- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 283 mlRVVEREAQTLSHNQHTLSFDVDNTLkVLGSEDELRSAISNLVYNAVNHTPKGThIAVCWQHTPAGAEFSVEDNGPGIG 362
Cdd:NF012226 218 --KVLKMFEDRLEQAQLTIVLNLTATP-VFCDRRRIEQVLIALIDNAIRYANAGK-LKISSSVIQDDWILQIEDEGPGIA 293
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515952576 363 PEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRlnIE-STLGKGTRFSFVIP 422
Cdd:NF012226 294 EEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGS--IEySNSQGNSVFTIKLP 352
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
321-422 |
4.09e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 70.92 E-value: 4.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 321 AISNLVYNAVNHTPKGTHIAVCWQhtPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSH 400
Cdd:cd16939 4 ALDNLLRNALRYAHRTVRIALLVS--GGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALW 81
|
90 100
....*....|....*....|...
gi 515952576 401 HESRLNI-ESTLGkGTRFSFVIP 422
Cdd:cd16939 82 HGGHVECdDSELG-GACFRLTWP 103
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
200-422 |
5.72e-14 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 74.12 E-value: 5.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 200 LEGAR--RNFFANVSHELRTPLTVLQGYlemmQEQTLEgapreKALHTMRE---QTfrMEGLVKQLLTL-------SKIE 267
Cdd:PRK11107 287 QEAARikSEFLANMSHELRTPLNGVIGF----TRQTLK-----TPLTPTQRdylQT--IERSANNLLAIindildfSKLE 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 268 AApSLALNDIidvPMMLRVVEREAQTL-SHNQHT----LSFDVDNTL--KVLGseDELR--SAISNLVYNAVNHTPKGtH 338
Cdd:PRK11107 356 AG-KLVLENI---PFSLRETLDEVVTLlAHSAHEkgleLTLNIDPDVpdNVIG--DPLRlqQIITNLVGNAIKFTESG-N 428
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 339 IAVCWQHTPAGA-----EFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGK 413
Cdd:PRK11107 429 IDILVELRALSNtkvqlEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNR 508
|
....*....
gi 515952576 414 GTRFSFVIP 422
Cdd:PRK11107 509 GSTFWFHLP 517
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
207-422 |
7.90e-14 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 73.47 E-value: 7.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 207 FFANVSHELRTPLTVLQGYLEMMQEQTL-EGAPRekALHTMREQTFRMEGLVKQLLTLSKIEA----------APSLALN 275
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLLQTKELpKGVDR--LVTAMNNSSSLLLKIISDILDFSKIESeqlkieprefSPREVIN 527
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 276 DIID--VPMMLRvvereaqtlshNQHTL-SF---DVDNTLkvLGSEDELRSAISNLVYNAVNHTPKGT---HIAVcwqht 346
Cdd:PRK10841 528 HITAnyLPLVVK-----------KRLGLyCFiepDVPVAL--NGDPMRLQQVISNLLSNAIKFTDTGCivlHVRV----- 589
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515952576 347 pAGA--EFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:PRK10841 590 -DGDylSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-407 |
1.05e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 67.10 E-value: 1.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 318 LRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIgPEH-LPRLTERFYRVDKARSRQTgGSGLGLAIVKH 396
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGI-PDYaLNRVFERFYSLPRPHSGQK-STGLGLAFVQE 82
|
90
....*....|.
gi 515952576 397 AVSHHESRLNI 407
Cdd:cd16945 83 VAQLHGGRITL 93
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
203-424 |
1.26e-13 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 73.02 E-value: 1.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 203 ARRNFFANVSHELRTPLTVLQGYLEMMQEQTLEGAPREKaLHTMREQTFRMEGLVKQLLTLSKIEA-APSLALNDIIDVP 281
Cdd:PRK11466 443 AKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDD-LRAITDSGESLLTILNDILDYSAIEAgGKNVSVSDEPFEP 521
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 282 M-----MLRVVE-REAQTLSHNQHTLSFDVDNTLKvlGSEDELRSAISNLVYNAVNHTPKGtHIAVCWQHTPAGAEFSVE 355
Cdd:PRK11466 522 RpllesTLQLMSgRVKGRPIRLATDIADDLPTALM--GDPRRIRQVITNLLSNALRFTDEG-SIVLRSRTDGEQWLVEVE 598
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515952576 356 DNGPGIGPEHLPRLTERFYRVDKARsrqtGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIPER 424
Cdd:PRK11466 599 DSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
189-422 |
1.33e-13 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 72.85 E-value: 1.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 189 MVARDVTQMHQLEgarrNFFANVSHELRTPLTVLQGYLEMMQEQTLEGApREKALHTMREQTFRMEGLVKQLLTLSKIEA 268
Cdd:TIGR03785 474 MVARLRQYTHYLE----NMSSRLSHELRTPVAVVRSSLENLELQALEQE-KQKYLERAREGTERLSMILNNMSEATRLEQ 548
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 269 apSLALNDIIDVPMMLRVVEREA---QTLSHNQHTLSFDVDNTLkVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQH 345
Cdd:TIGR03785 549 --AIQSAEVEDFDLSEVLSGCMQgyqMTYPPQRFELNIPETPLV-MRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQ 625
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515952576 346 TPAGAEFSVEDNGPGIgPEHLP-RLTERFYRVDKARSRQTGGSGLGLAIVKHAVSHHESRLNIESTL-GKGTRFSFVIP 422
Cdd:TIGR03785 626 NKSHALLTVSNEGPPL-PEDMGeQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQqNDGVVFRISLP 703
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
105-424 |
2.60e-13 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 70.88 E-value: 2.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 105 ESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPEFTLYLKKRDFSRPHN-------LKLNNGRH-LE 176
Cdd:PRK11073 14 NSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMRESLQAGQGftdnevtLVIDGRSHiLS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 177 IRVMPYSDRQWLMVARDVTQM---------HQLEGARRNFFANVSHELRTPLTVLQGylemmQEQTLEGAPREKAL---- 243
Cdd:PRK11073 94 LTAQRLPEGMILLEMAPMDNQrrlsqeqlqHAQQVAARDLVRGLAHEIKNPLGGLRG-----AAQLLSKALPDPALteyt 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 244 HTMREQTFRMEGLVKQLLTLSKieaaPSLALNDIIDvpmmlRVVEREAQTLS---HNQHTLSFDVDNTLKVLGSE-DELR 319
Cdd:PRK11073 169 KVIIEQADRLRNLVDRLLGPQR----PGTHVTESIH-----KVAERVVQLVSlelPDNVRLIRDYDPSLPELAHDpDQIE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 320 SAISNLVYNAVNH-TPKGTHIAV----CWQHTPAG------AEFSVEDNGPGIGPEHLPRLterFYRVDKARSrqtGGSG 388
Cdd:PRK11073 240 QVLLNIVRNALQAlGPEGGTITLrtrtAFQLTLHGeryrlaARIDIEDNGPGIPPHLQDTL---FYPMVSGRE---GGTG 313
|
330 340 350
....*....|....*....|....*....|....*.
gi 515952576 389 LGLAIVKHAVSHHESRLNIESTLGKgTRFSFVIPER 424
Cdd:PRK11073 314 LGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIR 348
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-422 |
3.34e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 65.38 E-value: 3.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 318 LRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARsRQTGGSGLGLAIVKHA 397
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKL 84
|
90 100
....*....|....*....|....*..
gi 515952576 398 VS--HHEsrLNIESTLGKGTRFSFVIP 422
Cdd:cd16948 85 CDklGHK--IDVESEVGEGTTFTITFP 109
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
301-421 |
6.57e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 65.35 E-value: 6.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 301 LSFDVDNTLKVLGSEDELRSAISNLVYNAVNHTPKgtHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDkar 380
Cdd:cd16954 21 ISLDISPELRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLD--- 95
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 515952576 381 sRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVI 421
Cdd:cd16954 96 -EQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-422 |
1.18e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 63.94 E-value: 1.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 318 LRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKarSRQTGGSGLGLAIVKHA 397
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 515952576 398 VSHHESRLNIEStLGKGTRFSFVIP 422
Cdd:cd16923 79 IELHGGSASAEY-DDNHDLFKVRLP 102
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
317-422 |
1.40e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 63.60 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 317 ELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSrqtgGSGLGLAIVKH 396
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYR 78
|
90 100
....*....|....*....|....*.
gi 515952576 397 AVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-422 |
1.80e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 60.38 E-value: 1.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 322 ISNLVYNAVNHTpKGTHIAVCWQHTPAGAE-----FSVEDNGPGIGPEHLPRLTERFYRvdkarSRQTGGSGLGLAIVKH 396
Cdd:cd16915 5 VGNLIDNALDAL-AATGAPNKQVEVFLRDEgddlvIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 515952576 397 AVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
315-421 |
5.21e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 59.40 E-value: 5.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 315 EDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARsRQTGGSGLGLAIV 394
Cdd:cd16975 2 TLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYIA 80
|
90 100
....*....|....*....|....*..
gi 515952576 395 KHAVSHHESRLNIESTLGKGTRFSFVI 421
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-422 |
5.73e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 59.12 E-value: 5.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 318 LRSAISNLVYNAVNHTPKGT-HIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYrVDKARSRQTG-GSGLGLAIVK 395
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 515952576 396 HAVSHHESRLNIES----TLGKGTRFSFVIP 422
Cdd:cd16953 80 QIIEAHGGISVAENhnqpGQVIGARFTVQLP 110
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
98-194 |
6.67e-10 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 56.27 E-value: 6.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 98 KRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLL-------RYPEFTLYLKKRDFSRP--HNLK 168
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIpeeddaeVAELLRQALLQGEESRGfeVSFR 80
|
90 100 110
....*....|....*....|....*....|...
gi 515952576 169 LNNGR--HLEIRVMPYSD-----RQWLMVARDV 194
Cdd:pfam00989 81 VPDGRprHVEVRASPVRDaggeiLGFLGVLRDI 113
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
211-419 |
1.69e-09 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 59.68 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 211 VSHELRTPLTVLQGYLEMMQ----EQTLEGAPREKALHTMREQTFRMEGLVKQLLTLS---KIEAAPsLALNDIIDVpmM 283
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIQaalsHPDADRGRMARSVENIRAAAERAATLTQQLLAFArkqRLEGRV-LNLNGLVSG--M 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 284 LRVVEReaqtlshnqhTLSFDVdnTLKVLGSED---------ELRSAISNLVYNAVNHTPKGTHIAVCWQ----HTPAGA 350
Cdd:PRK13557 247 GELAER----------TLGDAV--TIETDLAPDlwncridptQAEVALLNVLINARDAMPEGGRVTIRTRnveiEDEDLA 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 351 EF-----------SVEDNGPGIGPEHLPRLTERFYrvdkaRSRQTG-GSGLGLAIVKHAVSHHESRLNIESTLGKGT--R 416
Cdd:PRK13557 315 MYhglppgryvsiAVTDTGSGMPPEILARVMDPFF-----TTKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTtvR 389
|
...
gi 515952576 417 FSF 419
Cdd:PRK13557 390 LYF 392
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
306-418 |
3.05e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 54.83 E-value: 3.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 306 DNTLKVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYRVDKARSRQTG 385
Cdd:cd16947 9 DRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQ 88
|
90 100 110
....*....|....*....|....*....|...
gi 515952576 386 GSGLGLAIVKHAVSHHESRLNIESTLGKGTRFS 418
Cdd:cd16947 89 GNGLGLTITKRLAESMGGSIYVNSKPYEKTVFT 121
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-419 |
3.73e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 54.00 E-value: 3.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 324 NLVYNAVN--HTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYrvdkaRSRQTG-GSGLGLAIVKHAVSH 400
Cdd:cd16976 7 NLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSISYGIVEE 81
|
90
....*....|....*....
gi 515952576 401 HESRLNIESTLGKGTRFSF 419
Cdd:cd16976 82 HGGRLSVANEEGAGARFTF 100
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-422 |
3.82e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 53.94 E-value: 3.82e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 353 SVEDNGPGIGPEHLPRLterFYRVDKARSrqtGGSGLGLAIVKHAVSHHESRLNIESTLGKgTRFSFVIP 422
Cdd:cd16918 47 SVIDNGPGIPPDLQDTI---FYPMVSGRE---NGTGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-422 |
7.31e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 53.31 E-value: 7.31e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515952576 354 VEDNGPGIGPEHLPRLTERfYRVDKARsrqtgGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16944 46 VCDNGKGFPREMRHRATEP-YVTTRPK-----GTGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-422 |
9.16e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 52.78 E-value: 9.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 322 ISNLVYNAV----NHTPKGTHIAVcwQHTPAGAEF---SVEDNGPGIGPEHLPRLTERFYrvdkarSRQTGGSGLGLAIV 394
Cdd:cd16920 5 LINLVRNGIeamsEGGCERRELTI--RTSPADDRAvtiSVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 515952576 395 KHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| ActS_PrrB_HisK |
NF033792 |
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ... |
213-391 |
1.26e-08 |
|
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.
Pssm-ID: 468186 [Multi-domain] Cd Length: 423 Bit Score: 56.76 E-value: 1.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 213 HELRTPLTVLQgyL---EMMQEQTLEGAPREKAlHTMREQTFRMEGLVKQLLTLSKIEAApslalndIIDvPMMLRVVER 289
Cdd:NF033792 211 HELGTPLATIA--LvakELERELPDDPPLREDA-ELLRSQAERCRDILRRLTSLGEEGDA-------HLD-RLPLSALIE 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 290 EAQtlshNQHtLSFDVDNTLKVLGSED---------ELRSAISNLVYNAVNHTpkGTHIAVCWQHTPAGAEFSVEDNGPG 360
Cdd:NF033792 280 EAA----APH-RGFGKEIEVVVAGDPGeepvirrnpEILYGLGNLIENAVDFA--RSTVTVTASWDAESVTITIEDDGPG 352
|
170 180 190
....*....|....*....|....*....|.
gi 515952576 361 IGPEHLPRLTERFYRVDKARSRQTGGSGLGL 391
Cdd:NF033792 353 FPPDVLSRIGEPYVTTRRGEERRPGGGGLGL 383
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
211-414 |
2.23e-08 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 56.23 E-value: 2.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 211 VSHELRTPLTVLQGYLEMMqEQTLEGAPREKALHT---MREQTFRMEGLVKQLLTLSKIEAAP--SLALNDIIDVPMMLr 285
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSA-KKALEQENYAQLPTSldkIEGLIERMDKIIKSLRQFSRKSDTPlqPVDLRQVIEQAWEL- 517
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 286 vVEREAQTLshnQHTLSFDVDntLKVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPeh 365
Cdd:COG4192 518 -VESRAKPQ---QITLHIPDD--LMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL-- 589
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 515952576 366 LPRLTERFYrvdkarSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKG 414
Cdd:COG4192 590 VDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTLERG 632
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
318-422 |
2.64e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 52.00 E-value: 2.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 318 LRSAISNLVYNAVNHTPKGTHI--AVCWQHTPAGAE-------------FSVEDNGPGIGPEHLPRLTERFYRvdkarSR 382
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLtiETSNQRVDADYAlnyrdlipgnyvcLEVSDTGSGMPAEVLRRAFEPFFT-----TK 75
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 515952576 383 QTG-GSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16919 76 EVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
325-424 |
2.67e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 55.79 E-value: 2.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 325 LVYNAVNH----TPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFyrvdkarSRQTGGSGLGLAIVKHAVSH 400
Cdd:COG2972 344 LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKL 416
|
90 100
....*....|....*....|....*..
gi 515952576 401 H---ESRLNIESTLGKGTRFSFVIPER 424
Cdd:COG2972 417 YygeEYGLEIESEPGEGTTVTIRIPLE 443
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
321-422 |
2.57e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 48.58 E-value: 2.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 321 AISNLVYNAVNHTPK----GTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTERFYrvdkarsrqTGGSGLGLAIVK- 395
Cdd:cd16957 5 ALQVLVENAIRHAFPkrkeNNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTV---------TSEKGTGTALENl 75
|
90 100 110
....*....|....*....|....*....|.
gi 515952576 396 ----HAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16957 76 nrrlIGLFGSEACLHIESEVHGGTEVWFVIP 106
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
205-416 |
2.67e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 52.71 E-value: 2.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 205 RNFFANVSHELRTPLTVLQGYLEMM---QEQTLEgapreKALHTMREQTFRMEGLVKQLLTLSKIEAAPSLALNDIIDVP 281
Cdd:PRK10815 267 RTTLTDLTHSLKTPLAVLQSTLRSLrsgKQMSVE-----QAEPIMLEQISRISQQIGYYLHRASMRSEHNLLSRELHSVA 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 282 MML--------RVVEREAQTLShnqhtlsFDVDNTLKVLGSEDELRSAISNLVYNAVNHTPKGTHIAVCwqHTPAGAEFS 353
Cdd:PRK10815 342 PLLdnltsalnKVYQRKGVNIT-------LDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISAR--QTDEHLHIV 412
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515952576 354 VEDNGPGIGPEHLPRLTERFYRVDKARSrqtgGSGLGLAIVKHAVSHHESRLNI-ESTLGkGTR 416
Cdd:PRK10815 413 VEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAgDSPLG-GAR 471
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
316-422 |
4.97e-07 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 48.37 E-value: 4.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 316 DELRSAISNLVYNAVNHTPKG---THIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRlterfyrvdkaRSRQTGGSGLGLA 392
Cdd:COG2172 33 DDLVLAVSEAVTNAVRHAYGGdpdGPVEVELELDPDGLEIEVRDEGPGFDPEDLPD-----------PYSTLAEGGRGLF 101
|
90 100 110
....*....|....*....|....*....|
gi 515952576 393 IVKHAVshheSRLNIESTLGkGTRFSFVIP 422
Cdd:COG2172 102 LIRRLM----DEVEYESDPG-GTTVRLVKR 126
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-422 |
1.03e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 46.39 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 328 NAVNHTPkGTHIAVCWQHTPAGAEFSVEDNGPGIGPEhlprlterfyrvdkarsRQTGGSGLGLAIVKHAVSHHESRLNI 407
Cdd:cd16917 11 NALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRERAELLGGTLTI 72
|
90
....*....|....*
gi 515952576 408 ESTLGKGTRFSFVIP 422
Cdd:cd16917 73 GSRPGGGTRVTARLP 87
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
99-152 |
1.24e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 45.47 E-value: 1.24e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 515952576 99 RFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPEF 152
Cdd:smart00091 2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDR 55
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
87-204 |
1.60e-06 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 49.25 E-value: 1.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 87 KKRRRELGSLIKRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPEFTLYLK--------- 157
Cdd:COG2202 126 KRAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLEllrrllegg 205
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 515952576 158 KRDFSRPHNLKLNNGRHLEIRVMPYSDRQ------WLMVARDVTQMHQLEGAR 204
Cdd:COG2202 206 RESYELELRLKDGDGRWVWVEASAVPLRDggevigVLGIVRDITERKRAEEAL 258
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
107-213 |
1.99e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 46.09 E-value: 1.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 107 LPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPEFTLYLKKRDfsrpHNLKLNNGRHLEIRVMPYsDRQ 186
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLE----NLLSGGEPVTLEVRLRRK-DGS 75
|
90 100
....*....|....*....|....*..
gi 515952576 187 WLMVARDVTQMHQLEGARRNFFANVSH 213
Cdd:cd00130 76 VIWVLVSLTPIRDEGGEVIGLLGVVRD 102
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
98-204 |
1.99e-06 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 46.52 E-value: 1.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 98 KRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYP---EFTLYLKKRDFSRPH------NLK 168
Cdd:TIGR00229 3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEdreEVRERIERRLEGEPEpvseerRVR 82
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 515952576 169 LNNG--RHLEIRVMPYSD----RQWLMVARDVTQMHQLEGAR 204
Cdd:TIGR00229 83 RKDGseIWVEVSVSPIRTnggeLGVVGIVRDITERKEAEEAL 124
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
299-422 |
3.25e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 49.14 E-value: 3.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 299 HTLSFDVDNTLKVLGSED---ELRSAISNLVYN---AVNHTPKGThIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTER 372
Cdd:PRK11086 412 ITLIISEDSQLPDSGDEDqvhELITILGNLIENaleAVGGEEGGE-ISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDK 490
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 515952576 373 FYrvdkarSRQTGGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:PRK11086 491 GY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
308-422 |
3.42e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 48.08 E-value: 3.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 308 TLKVLGSEDELRSAISNLVY--------NAVNHTpKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPrlterfyrvdka 379
Cdd:COG4585 145 ELDVDGDPDRLPPEVELALYrivqealtNALKHA-GATRVTVTLEVDDGELTLTVRDDGVGFDPEAAP------------ 211
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 515952576 380 rsrqtgGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:COG4585 212 ------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
81-201 |
6.04e-06 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 48.23 E-value: 6.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 81 QMQMRNKKRRRELGSLIkrfrsgaESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPEFTLYLKKRD 160
Cdd:COG3829 1 AEELELKELEEELEAIL-------DSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVLKTGK 73
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 515952576 161 FSRPHNLKLNN-GRHLEIRVMP-YSDRQWLMV---ARDVTQMHQLE 201
Cdd:COG3829 74 PVTGVIQKTGGkGKTVIVTAIPiFEDGEVIGAvetFRDITELKRLE 119
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-422 |
1.17e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 43.99 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 322 ISNLVYNAVNHTPK----GTHIAVCWQHTPA-GAEFSVEDNGPGIGPEHLPRLterfyrvdkaRSRQTGGSGLGLAIVKH 396
Cdd:cd16955 6 IQPLVENAIVHGIQekkgKGVVKISVKKQLKnRLHIAVEDNGIGISPKVIERV----------EQDEMPGNKIGLLNVHQ 75
|
90 100
....*....|....*....|....*..
gi 515952576 397 AVSH-HESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16955 76 RLKLgYGEGLHIRSRPDPGTLIAFYIP 102
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
321-404 |
2.04e-05 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 43.03 E-value: 2.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 321 AISNLVYNAVNHTPKGTH---IAVCWQHTPAGAEFSVEDNGPGIGPeHLPRLTERFYRVdkarsrqtggSGLGLAIVKHA 397
Cdd:cd16936 4 AVSEAVTNAVRHAYRHDGpgpVRLELDLDPDRLRVEVTDSGPGFDP-LRPADPDAGLRE----------GGRGLALIRAL 72
|
....*..
gi 515952576 398 VSHHESR 404
Cdd:cd16936 73 MDEVGYR 79
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
88-205 |
2.86e-05 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 45.40 E-value: 2.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 88 KRRRELGSLIKRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPEFTLYLK--------KR 159
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLEllraalagGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 515952576 160 DFSRPHNLKLNNG--RHLEIRVMPYSDRQ-----WLMVARDVTQMHQLEGARR 205
Cdd:COG2202 81 VWRGELRNRRKDGslFWVELSISPVRDEDgeitgFVGIARDITERKRAEEALR 133
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
173-422 |
3.09e-05 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 46.46 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 173 RHLEIRVMPYS--------DRQwLMVARDVTQMHQL----EGARRNFFANVSHELRTPLTVLQGYLEMMQeQTLEGAPRE 240
Cdd:PRK10618 408 RMFRSQLAPRTqlfllrdqDRE-VLVNKKLQQAQREyeknQQARKAFLQNIGDELKQPLQSLAQLAAQLR-QTSDEEQQQ 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 241 KALHTMREQTFRMEGLVKQLLTLSKIEA------APSLALNDIID--VPMMLRVVEREAQTLSHNQHtlsFDVDNTLkvL 312
Cdd:PRK10618 486 PELDQLAEQSDVLVRLVDNIQLLNMLETqdwkpeQELFSLQDLIDevLPEVLPAIKRKGLQLLIHNH---LKAEQLR--I 560
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 313 GSEDELRSAISNLVYNAVNHTPKGtHIAVCWQHTPAGAE---FSVEDNGPGIGPE-----HLPRLTE----RFYRvdkar 380
Cdd:PRK10618 561 GDRDALRKILLLLLNYAITTTAYG-KITLEVDQDESSPDrltIRILDTGAGVSIKeldnlHFPFLNQtqgdRYGK----- 634
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 515952576 381 srqtgGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:PRK10618 635 -----ASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLK 671
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-422 |
3.20e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 42.82 E-value: 3.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 325 LVYNAVNH-----TPKGThIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTErfyrvdkarsRQTGGSGLGLAIVKHAVS 399
Cdd:cd16924 9 LVENAIQHglsplTDKGV-VTISALKEDNHVMIEVEDNGRGIDPKVLNILGK----------KPKEGNGIGLYNVHQRLI 77
|
90 100
....*....|....*....|....*.
gi 515952576 400 H---HESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16924 78 LlfgEDYGIHIASEPDKGTRITFTIP 103
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
316-421 |
3.76e-05 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 43.05 E-value: 3.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 316 DELRSAISNLVYNAVNH---TPKGTHIAVCWQHTPAGAEFSVEDNGPGIGPEHLPRLTErfyrVDKARSRQTGgsGLGLA 392
Cdd:pfam13581 30 DEVELAVGEACTNAVEHayrEGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDL----EEPDEDRKEG--GRGLA 103
|
90 100
....*....|....*....|....*....
gi 515952576 393 IVKHAVSHHESRLNiestlGKGTRFSFVI 421
Cdd:pfam13581 104 LIRGLMDDVEYTRG-----GEGNTVRMRK 127
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
325-424 |
1.06e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 44.51 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 325 LVYNAVNH----TPKGtHIAVCWQHTPAGAEFSVEDNGPGIGPEhlprlterfyrVDKARSRqtggsGLGLAIVKHAVSH 400
Cdd:COG3920 407 LVTNALKHaflsGEGG-RIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQ 469
|
90 100
....*....|....*....|....
gi 515952576 401 HESRLNIEStlGKGTRFSFVIPER 424
Cdd:COG3920 470 LGGTLELDR--PEGTRVRITFPLA 491
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
98-153 |
2.29e-04 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 39.07 E-value: 2.29e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 515952576 98 KRFRSGAESLPDAVILTTEEGTIFWCNGLAQQLLGLRWPDDNGQNILNLLRYPEFT 153
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLED 56
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
105-199 |
3.44e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 40.09 E-value: 3.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 105 ESLPDAVILTTEEGTIFWCNG--------LAQQLLGLRWPDdngqnILNLLRYPEFTLYLKK-----RDFSRPHNLKLN- 170
Cdd:pfam08448 2 DSLPDALAVLDPDGRVRYANAaaaelfglPPEELLGKTLAE-----LLPPEDAARLERALRRalegeEPIDFLEELLLNg 76
|
90 100 110
....*....|....*....|....*....|....
gi 515952576 171 NGRHLEIRVMPYSDRQ-----WLMVARDVTQMHQ 199
Cdd:pfam08448 77 EERHYELRLTPLRDPDgevigVLVISRDITERRR 110
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
308-422 |
2.56e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 38.72 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 308 TLKVLGSE--------DELRSAISNLVYNAVNH-------------TPKGThIAVCWQHTPAGAEFSVEDNGPGIGPEH- 365
Cdd:cd16916 21 ELVVEGEDteldksvlEKLADPLTHLLRNAVDHgieapeerlaagkPPEGT-ITLRAEHQGNQVVIEVSDDGRGIDREKi 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515952576 366 LPRLTERFYRVDKARSRQT----------------------GGSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:cd16916 100 REKAIERGLITADEAATLSddevlnlifapgfstaeqvtdvSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
386-422 |
2.97e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 39.78 E-value: 2.97e-03
10 20 30
....*....|....*....|....*....|....*..
gi 515952576 386 GSGLGLAIVKHAVSHHESRLNIESTLGKGTRFSFVIP 422
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
317-416 |
5.46e-03 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 36.58 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515952576 317 ELRSAISNLVYNAVNHTPKG-THIAVCWQHTPAGAEFSVEDNGPGIGpehlprlterfyRVDKARS---RQTGGSGLGLA 392
Cdd:cd16934 25 EIATAVTELARNLLKHAGGGqVLLEVVAEGGRVALEILAVDQGPGIA------------DVDEALRdgfSTGGGLGLGLG 92
|
90 100
....*....|....*....|....
gi 515952576 393 IVKHAVshheSRLNIESTLGKGTR 416
Cdd:cd16934 93 GVRRLA----DEFDLHSAPGRGTV 112
|
|
| |
