|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
39-408 |
4.21e-83 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 259.02 E-value: 4.21e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 39 TLALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLL 118
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 119 STMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIG 198
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 199 CFALASALMFWKILPESRHFRPTSLRpktLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQALV 278
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLG---LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 279 GLLSVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFGLLMTLFS-SLWLIFAGMLLFSAGFFAAHSVASSWIGPRAR 357
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGpSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 515953973 358 RAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFIALMLCAALLV 408
Cdd:cd17324 318 EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
37-378 |
7.61e-40 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 145.50 E-value: 7.61e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 37 RVTLALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCT 116
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 117 LLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAV 196
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 197 IGCFALASALMFWKILPESRHFRPTSLRPktlfiNFRLHWRDQGLPRLFLTGFLLMGSFVTLFNYIGYRLMlSPWHLSQA 276
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRG-----SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ-EVLGLSAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 277 LVGLLSVAY-LTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFGL-LMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGP 354
Cdd:COG2814 244 AAGLLLALFgLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLlLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
330 340
....*....|....*....|....*
gi 515953973 355 RA-RRAKGQASSLYLFSYYLGSSIA 378
Cdd:COG2814 324 LApPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
42-408 |
2.84e-30 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 119.99 E-value: 2.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 42 LFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTM 121
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 122 MTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFA 201
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 202 LASALMFWKILPESRHFRPT-SLRPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLFNYIGYRLMlSPWHLSQALVGL 280
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKrAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA-ELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 281 L-SVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVM-LFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-R 357
Cdd:cd17325 240 LfGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSaVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVpP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 515953973 358 RAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFIALMLCAALLV 408
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVL 370
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
58-413 |
3.21e-24 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 103.04 E-value: 3.21e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 58 PILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGL 137
Cdd:cd17320 20 PALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 138 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPESRH 217
Cdd:cd17320 100 GAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 218 FRPTSLRPKTLFINFRLHWRDqglPRLFLTGFLLMGSFVTLFNYIGYR--LMLSPWHLSQALVGLL----SVAYLTGTWS 291
Cdd:cd17320 180 EEKRKPLLSSLLRAYKRVLKN---RRFLGYALALGLSFAGLFAYLAAApfIYIEQLGLSPAQFGLLfalnAIALILGSLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 292 SPKAG---AMTARFGRGPVMLVSTAVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRARRAKGQASSLYL 368
Cdd:cd17320 257 NGRLVrrfGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLG 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 515953973 369 FSYYLGSSIAGTLGGVFWHNYGWNgvggFIALMLCAALLVGASLH 413
Cdd:cd17320 337 FLQFLIGALAGALVGLLPNGTALP----MGLLILVLGLLALLLLI 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
29-416 |
2.15e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 97.63 E-value: 2.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 29 KRGTPQFMRVTLALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTA 108
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 109 LMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFF 188
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 189 NWRIALAVIGCFALASA-LMFWkilpesrhfrptslrpktlfinfrlhwrdqglpRLFLTGFLLMGSFVTLFNYIGYRLM 267
Cdd:COG2271 162 GWRAAFLILGLPGLLLAlLRFW---------------------------------LLALAYFLVYFALYGFLTWLPTYLV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 268 LSpWHLSQALVGLL-SVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFG---LLMTLFSSLWLIFAGMLLFSAGFFA 343
Cdd:COG2271 209 EV-RGLSLAQAGLLlSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAlalLLLALLPSPALAIALLFLAGFGLGG 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515953973 344 AHSVASSWIGPRA-RRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFIALMLCAALLVGASLHKRL 416
Cdd:COG2271 288 AFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
56-408 |
1.03e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 95.72 E-value: 1.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 56 VQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALI 135
Cdd:cd17474 18 VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 136 GLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDfFNWRIALAVIGCFALASALMFWKILPES 215
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 216 RhfRPTSLRPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLFNY----IGYRLMLSPWH----LSQALVGLLSVAYLT 287
Cdd:cd17474 177 K--EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYlpflLELLYGISPIIigllFAGWSVLLALGSLFV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 288 GTWSspkagamTARFGRGPVMLVSTAVMLFGLLMTLFS-SLWLIFAGMLLFSAG---FFAAHSVASSWIGPRARRAKgqA 363
Cdd:cd17474 255 GRLL-------KKRFGARRILVIGLLLYALSLLLLGFVpSLALLLIAIVLFGLGlglNLPLLTTLVTELAPEEERGT--A 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 515953973 364 SSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFIALMLCAALLV 408
Cdd:cd17474 326 SSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-412 |
4.54e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 94.18 E-value: 4.54e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 36 MRVTLALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVC 115
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 116 TLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALA 195
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 196 VIGCFALASALMFWKILPESRHFRPTSlrPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLFNYIGyRLMLSPWHLSQ 275
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAA--AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP-PYLVDQFGLSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 276 ALVGLL-SVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFGLLMTLFS--SLWLIFAGMLLFSAGFFAAHSVASSWI 352
Cdd:COG2223 241 ATAGLLaALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAlgSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515953973 353 GPR-ARRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGwNGVGGFIALMLCAALLVGASL 412
Cdd:COG2223 321 PDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG-SYTAAFLVFAVLALVALVLTL 380
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
42-378 |
1.08e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 89.40 E-value: 1.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 42 LFSAGLATFALLYCVQPILP-VLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLST 120
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 121 MMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCF 200
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 201 ALASALMFWKILPESRHFRPTSLRPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQALVGL 280
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 281 LSVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFG----LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRA 356
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAalglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|...
gi 515953973 357 -RRAKGQASSLYLFSYYLGSSIA 378
Cdd:pfam07690 321 pKEERGTASGLYNTAGSLGGALG 343
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
40-415 |
2.23e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 89.16 E-value: 2.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 40 LALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLS 119
Cdd:COG2807 21 LAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 120 TMMTSWHGILVMRALIGLSLsGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGC 199
Cdd:COG2807 101 SLAPSVALLLAGTALIGAGI-AVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWAL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 200 FALASALMFWKILPESRHFRPTSLRPKTLfinfRLHWRDQGLPRLFLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQAlVG 279
Cdd:COG2807 180 LALLALLLWLPLLRRRPAAAAAAPAAASL----RSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATA-GL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 280 LLSVAYLTGTWSSPKAGAMTARFG-RGPVMLVSTAVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRARR 358
Cdd:COG2807 255 LLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRART 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 359 AK--GQASSLYLFSYYLGSSIAGTLGGVFW-HNYGWNGVGGFIALMLCAALLVGASLHKR 415
Cdd:COG2807 335 PAeaAALSGMAQSVGYLLAALGPLLVGALHdATGSWTAALLLLAALAVLMLVAGLLAGRP 394
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
59-363 |
7.89e-19 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 87.80 E-value: 7.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 59 ILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLS 138
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 139 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPESRHF 218
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 219 ----RPTSLRPKTLFINFRLHWRDQ-GLP--------------------RLFLTGFLLMGSFVTLF------NYIGYRLM 267
Cdd:TIGR00895 199 lvskRPETVRRIVNAIAPQMQAEAQsALPeqkstqgtkrsvfkalfqgkTARITVLLWLLYFMLLVgvyfltNWLPKLMV 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 268 LSPWHLSQALVGLLSVaYLTGTWSSPKAGAMTARFGRGPVMLVS--TAVMLFGLLMTLFSSLWLIFAGML--LFSAGFFA 343
Cdd:TIGR00895 279 ELGFSLSLAATGGALF-NFGGVIGSIIFGWLADRLGPRVTALLLllGAVFAVLVGSTLFSPTLLLLLGAIagFFVNGGQS 357
|
330 340
....*....|....*....|
gi 515953973 344 AHSVASSWIGPRARRAKGQA 363
Cdd:TIGR00895 358 GLYALMALFYPTAIRATGVG 377
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
42-412 |
1.25e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 86.71 E-value: 1.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 42 LFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTM 121
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 122 MTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDF--FNWRIALAVIGC 199
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 200 FALASALMFWKILPESRH---FRPTSLRPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQA 276
Cdd:cd06174 161 LALLAAILLLLVVPDPPEsarAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 277 LVGLLSVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAV--MLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIG- 353
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLlmALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAe 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 515953973 354 PRARRAKGQASSLYLFSYYLGSSIAGTLGGvFWHNYGWNGVGGFIALMLCAALLVGASL 412
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAG-FLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
42-385 |
1.51e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 83.40 E-value: 1.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 42 LFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTM 121
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 122 MTSWHGILVMRALIGLSLsGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFA 201
Cdd:cd17504 81 APNLPVLIAGRALQGIGG-AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 202 LASALMFWKILPesRHFRptslRPKTLFINfrlhwrdqglprlfLTGFLLMGSFVTLFNYIGYRLMLSPWH---LSQALV 278
Cdd:cd17504 160 VLLAALVPLIDL--RLLR----RRNVLLAN--------------ITALLAGFGMFMVFQLLPQLLQLPTPTgfgLGITEA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 279 GLLSVAY-LTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFGLLMTLF--SSLWLIFAGMLLFSAGF-FAAHSVASSWIGP 354
Cdd:cd17504 220 GLLLLPGaLVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALlhSSLWALVVALLLIGIGLgLAFASLPNIVVES 299
|
330 340 350
....*....|....*....|....*....|.
gi 515953973 355 RARRAKGQASSLYLFSYYLGSSIAGTLGGVF 385
Cdd:cd17504 300 VPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
59-385 |
4.11e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 79.14 E-value: 4.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 59 ILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLS 138
Cdd:cd17321 18 ALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 139 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMfwkilpeSRHF 218
Cdd:cd17321 98 AAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL-------ARTF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 219 RPTSLrpktlfinfrlhwrdqglpRLFLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQALVGLlsvaYLTGTWSSPKAGAM 298
Cdd:cd17321 171 SGAVL-------------------AAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPL----ALAMLVAAPLAGRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 299 TARFGRGPVMLVSTAVMLFGLLMTLF----SSLWLIFAGMLLFSAGF-FAAHSVASSWIGPRARRAKGQASSLYLFSYYL 373
Cdd:cd17321 228 ADRFGPRLVLVAGLLLTAVGLLLLALlgadSSVWLLLPGLVLLGLGLgLFATPLTNAALSSVPKEKAGAASGILNTARQL 307
|
330
....*....|..
gi 515953973 374 GSSIAGTLGGVF 385
Cdd:cd17321 308 GGALGVALLGAL 319
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
32-415 |
1.88e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 77.59 E-value: 1.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 32 TPQFMRVTLALFSAGLATFALLYCVQ-PILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALM 110
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWgPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 111 LASVCTLLSTMMTSWHGILVMRALIGLSLsGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDF--- 187
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGL-GLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLgls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 188 FNWRIALAVIGCFALASALMFWKI-LPESrhfRPTSLRPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLFNYIGyRL 266
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSkLPEI---EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLP-LY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 267 MLSPWHLSQALVGLL----SVAYLTGTWSspkAGAMTARFGRGPVMLVSTAVMLFGLLMTLFSS-LWLIFAGMLLFSAGF 341
Cdd:COG0738 237 LKDVLGLSEATAALGlslfWGGMTIGRFL---GGFLLKRFGPVRLLRLSALLAAVGLLLALLAPgPWLALIGLALVGLGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515953973 342 FAAHSVASSWIGPRARRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFIALMLCAALLVGASLHKR 415
Cdd:COG0738 314 SLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRK 387
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
36-319 |
1.35e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 73.69 E-value: 1.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 36 MRVTLALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVC 115
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 116 TLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALA 195
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 196 VIGCFALASALMFWKiLPESRHFRPTSLRPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQ 275
Cdd:COG0477 173 INAPLGLLALVLRLR-LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 515953973 276 ALVGLLSVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFGL 319
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
42-408 |
1.48e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 74.55 E-value: 1.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 42 LFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTM 121
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 122 MTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFA 201
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 202 LASALMFWKIlpesrhfRPTSLRPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTlFNYIGYRLMLSPWHLSQALVGLL 281
Cdd:cd17489 161 LLALLLVFLV-------KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIA-YGAISTFLPLYAAERGISNAGLF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 282 SVAY-LTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFGLLMTLFS-SLWLIFAGMLLFSAGFFAAHSVASSWIGPRARRA 359
Cdd:cd17489 233 FTVYaIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAgSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPH 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 515953973 360 K-GQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFIALMLCAALLV 408
Cdd:cd17489 313 RrGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
38-412 |
2.33e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 73.75 E-value: 2.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 38 VTLALFSAGLATFALLycvqPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTL 117
Cdd:cd17477 1 LLLSVALLGLGSGLLL----PLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 118 LSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLsGVFTDFFNWRIALAVI 197
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALPFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 198 GCFALASALMFWKILPESRHFRPTSLRPKTLFINFRLhwrdqGLPRLFLTGFLLmGSFVTLFNYIGYRLMLSpwhlSQAL 277
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIAPL-----ALLGAFVAGFLE-GAFYSLLPLYGLRLGLS----VAQA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 278 VGLLSVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFG--LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPR 355
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAalLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDR 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 515953973 356 ARRAK-GQASSLYLFSYYLGSSIAGTLGGVFwhnYGWNGVGGFIALMLCAALLVGASL 412
Cdd:cd17477 306 LPGDElVAANAALLLLYGLGSVIGPLLAGAL---MDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
37-209 |
8.93e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.22 E-value: 8.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 37 RVTLALFSAGLATFALLYCVQPILPV-LSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVC 115
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 116 TLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALA 195
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
170
....*....|....
gi 515953973 196 VIGCFALASALMFW 209
Cdd:cd17325 359 AAAALLLLAAVLFL 372
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
59-343 |
1.84e-13 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 71.08 E-value: 1.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 59 ILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLS 138
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 139 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILpesrhf 218
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 219 rptslrpktlfinfrlhwrdqglpRLFLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQALVGLLSVAyLTGTWSSPKAGAM 298
Cdd:cd17365 175 ------------------------LLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLN-IGGVIGSLLLGWL 229
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 515953973 299 TARFGRGPVMLVSTAVMLFGLLMTLFSSLWLIFAGMLLFSAGFFA 343
Cdd:cd17365 230 ADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACV 274
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
93-412 |
2.68e-13 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 70.71 E-value: 2.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 93 GPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGlslSG-VAAVGMTYLSEEIHPSFVAFSMGLYISGNS 171
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG---SGaISSVVMALLADLTREENRTKAMALIGASIG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 172 IGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPESRHFRPTSLRPKTLFINFRLHWRdqgLPRLFLTGFLL 251
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKR---LLRLDFSIFIL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 252 MGSFVTLFNYIGYRLMLSPWHLSQALVGLLSVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFGLLMTLFS--SLWL 329
Cdd:cd17472 207 HFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAatSLWL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 330 IFAGMLLFSAGFFAAHSVASSWIGPRAR-RAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFIaLMLCAALLV 408
Cdd:cd17472 287 LIIGLIIFFIGFNLLEALLPSLVSKIAPkEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTI-LILALLWLL 365
|
....
gi 515953973 409 GASL 412
Cdd:cd17472 366 VSFL 369
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-412 |
5.29e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 69.89 E-value: 5.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 56 VQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALI 135
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 136 GLSLSGVAAVGMTYLSEeIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPES 215
Cdd:cd17478 95 GIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 216 RHFRPTSLRPKTLFINFRLHWRdqglPRLFLTGFLLMGSFVT--LFNYIGYRLMLSPWHLSQALVgLLSVAYLTGTWSSP 293
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWR----ALLLLLIIVFLRSWVLssLTTFLPFYLVQRGYSLVFAGL-LLSLFLFAGAIGTL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 294 KAGAMTARFGRGPVMLVSTAVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRARRAKGQASSLYL-FSYY 372
Cdd:cd17478 249 IGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMgLSFG 328
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 515953973 373 LGSSIAGTLGGVFWHnygwngVGGFIALMLCAALLVGASL 412
Cdd:cd17478 329 LGGIGAPVLGALADA------FGLESVLLILALLPLLGAL 362
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
39-410 |
5.46e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 69.55 E-value: 5.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 39 TLALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLA--IGLLFTGPLSDAIGRKQVMVTALMLASVCT 116
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGrpIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 117 LLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFF----NWRI 192
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 193 ALAVIGCFALASALMFWKILpesrhfrptslrpktlfinfrlhwrdqglpRLFLTGFLLMGSFVTLFNYIGYRLMLSPWH 272
Cdd:cd17316 161 LFLIGALPALLALLLRRRTL------------------------------LLILLWFFISFGYYGLTTFLPTYLQTVLGL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 273 LSQALVGLLSVAYLTGTWSSPKAGAMTARFGRGPVMLVS---TAVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVAS 349
Cdd:cd17316 211 SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGlilSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALY 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515953973 350 SWIG---PRARRAKGQAsslylFSY---YLGSSIAGTLGGVFWHNYGWNGVGGFIALMLCAALLVGA 410
Cdd:cd17316 291 AYLAelfPTEVRATGVG-----LSYnlgRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
56-408 |
2.39e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.95 E-value: 2.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 56 VQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALI 135
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 136 GLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPES 215
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 216 RHFRPTSLRPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLFNYIGYRLmLSPWHLSQALVG-LLSVAYLTGTWSSPK 294
Cdd:cd17475 175 PAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFL-HDHLGLSVVAAGaLLAVAQLGGALGRIG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 295 AGAMTARFGRG---PVMLVSTAVMLFGLLMTLF----SSLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-RRAKGQASSL 366
Cdd:cd17475 254 LGRVSDRVFGGrrrPVLVITAAIAAAALLVLSLlspgTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAgPEQAGTALGL 333
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 515953973 367 YLFSYYLGSSIAGTL-GGVFWHNYGWNGVGGFIALMLCAALLV 408
Cdd:cd17475 334 ANTINFIGIAIGPPLfGLLVDATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
59-408 |
5.83e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 63.36 E-value: 5.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 59 ILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLS 138
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 139 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPesrhf 218
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR----- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 219 rptslrpktLFInfrlhwrdqglprLFLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQALVGLL-SVAYLTGTWSSPKAGA 297
Cdd:cd17319 180 ---------QVW-------------GLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLaAIPFLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 298 MTARF---GRGPVMLVSTAVMLFGL-LMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRARRAK-GQASSLYLFSYY 372
Cdd:cd17319 238 LSDRLlrgARRLVIIIGLLLAAVGLlLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAaATAGGLINSGGN 317
|
330 340 350
....*....|....*....|....*....|....*..
gi 515953973 373 LGSSIAGTL-GGVFWHNYGWNGVGGFIALMLCAALLV 408
Cdd:cd17319 318 LGGFVAPLLiGYLVDATGSYTAAFLFLAAVALLAALL 354
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
37-413 |
7.99e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 63.06 E-value: 7.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 37 RVTLALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCT 116
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 117 LLSTMMTS-WHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALA 195
Cdd:cd17355 83 VLLALATSlWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 196 VIGCFALA----SALMFWKILPESRHFRPTSLRPKTLFINFRLHWRDQGLPRL----FLTGFLLMGSFVTLFNYIGYRLM 267
Cdd:cd17355 163 VLALLALLvlvpVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLalafFLCGFAVVGLIVHLVPYLADRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 268 lsPWHLSQALVGLLSVAYLTGTWSSpkaGAMTARFGRGPVMLVS---TAVMLFGLLMTLFSSLWLIFAGMLLfsaGFFAA 344
Cdd:cd17355 243 --SPAAAAVALALIGLFNIVGRLLS---GWLGDRYSPRRLLAASyalRALGLALLLLLPFPPLALLLFAALF---GLGWG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515953973 345 HSVASSWIGPRARRAKGQASSLY---LFSYYLGSSIAGTLGGVFwhnYGWNGVGGFIALMLCAALLVGASLH 413
Cdd:cd17355 315 ATVPLTAALAARYFGARSYGTLFglvFAPHQLGSALGPWLGGLL---YDRTGSYTAAWALAVALGLIAALLV 383
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
84-374 |
1.08e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 62.59 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 84 MLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSM 163
Cdd:cd17473 47 FIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKML 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 164 GLYISGNSIGGMSGRLLSGVFTDfFNWRIALAVIGcFALASALMFWKILPESRHFRPTSLRPKTLfINFRLHWRDQGLpr 243
Cdd:cd17473 127 GLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFLPEPARKSKSAASPGAA-TAAALPWKRVLP-- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 244 LFLTGFLLMGSFVTLFNYIGYrLMLSPWHLSQALVGL-LSVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFG-LLM 321
Cdd:cd17473 202 IYFLAFLAMLLFYVIPIQLPF-LLQERGGGSAALIGLaLAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGfLLL 280
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 515953973 322 TLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-RRAKGQASSLYLFSYYLG 374
Cdd:cd17473 281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVpPELRGRAMGIVTSAFFLG 334
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
84-361 |
1.87e-10 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 62.31 E-value: 1.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 84 MLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGI--------LVMRALIGLSLSGVAAVGMTYLSEEIH 155
Cdd:cd17367 52 MRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIgiwapiilLLARLLQGLSVGGEYGTSATYLSEVAP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 156 PS----FVAFSMGLYISGNSIGGMSGRLLSGVFTD----FFNWRIALAVIGCFALAsALMFWKILPESRHFRPTSLRPKT 227
Cdd:cd17367 132 PGrrgfYSSFQYVTLIGGQLLALGVLLVLQHTLGEdqmaAWGWRIPFLLGGVLAVV-VLWLRRGLEETESFEAIAESNEA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 228 ---LFINFRLHWRDqglprLFLTGFLLMGSFVTLFNYIGY--RLMLSPWHLSQALVGLLSVAYLT-GTWSSPKAGAMTAR 301
Cdd:cd17367 211 sagTLRELRRHPRE-----LLLVVGLTAGGTLAFYTWTTYlqKFLVNTAGFSKGDATWITTAALLvFMLLQPLGGRLSDR 285
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515953973 302 FGRGPVMLVST---AVMLFGLLMTL--FSSLWLIFAGM---LLFSAGFFAAHSVASSWIGPRARRAKG 361
Cdd:cd17367 286 IGRRPLLLFFGiggTLATVPLLSALdhTDSPYTAFALVlvgLVFLSGYTSINAVVKAELFPTHVRALG 353
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
58-381 |
8.19e-10 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 60.09 E-value: 8.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 58 PILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGL 137
Cdd:TIGR00710 26 PAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 138 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPESRH 217
Cdd:TIGR00710 106 GASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 218 FRPTSlRPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLFNyIGYRLMLSPWHLSQALVGLL----SVAYLTGTWSSP 293
Cdd:TIGR00710 186 YEARI-QISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFS-GAPFVYIDIMGVSPSVFGLLfalnIIAMIFGGFLNG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 294 KAGAMTARFGRGPVMLVSTAVMLFGLLMTLFSSLW---LIFAGMLLFSAGFFAAHSVASSWIGPRARRAKGQASSLYLFS 370
Cdd:TIGR00710 264 RFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGswaMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASALFGTL 343
|
330
....*....|.
gi 515953973 371 YYLGSSIAGTL 381
Cdd:TIGR00710 344 RLVLGAIVGYL 354
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
39-216 |
9.19e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.88 E-value: 9.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 39 TLALFSAGLATFALLYCVQPILPV-LSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGR--KQVMVTALMLASVC 115
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 116 TLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALA 195
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170 180
....*....|....*....|.
gi 515953973 196 VIGCFALASALMFWKILPESR 216
Cdd:COG2271 342 LLAALALLAALLALLLLRETR 362
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
58-343 |
1.05e-09 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 59.54 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 58 PILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGL 137
Cdd:PRK11102 12 PALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 138 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPES-R 216
Cdd:PRK11102 92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETlP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 217 HFRPTSLRPKTLFINFRLHWRDQGLPRLFLTG---------FLLMGSFVtlfnYIGYrlmlspWHLSQALVG---LLSVA 284
Cdd:PRK11102 172 KERRQPFHLRTTIRNFASLFRHKRVLGYMLASgfsfagmfsFLTAGPFV----YIEL------NGVSPQNFGyyfALNIV 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 515953973 285 YLTgtwsspkagAMTARFGRGPVMLVSTAVMLFGLLMTLFSSLWLIFAGmlLFSAGFFA 343
Cdd:PRK11102 242 FLF---------VMTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVSA--LLDLGFWA 289
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
59-410 |
1.63e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 59.24 E-value: 1.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 59 ILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLS 138
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 139 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKI---LPES 215
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIrrfVKEP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 216 ------RHFRPTSLRPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLF---NYIGYRLMLSPWHLSQALVGLLSVAYL 286
Cdd:cd17371 181 pqwqaaRAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTwlpSYLTGERGLSFEGSAGYLVVTILGGFL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 287 tGTWSspkAGAMTARFGRGPVMLVSTAVMLFGLLMTLFSS------LWLIFAGmLLFSAGFFAAHSVASSWIGPRARRAK 360
Cdd:cd17371 261 -GYLA---GGFLADRIGRRNNFALFALGSAISILLYFFLPlsptliLILGFPL-GFFASGPFSGMGAYLTELFPTAVRAT 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 515953973 361 GQAsslylFSYYLGSSIAG---TLGGVFWHNYGWNGVGGFIALMLCAALLVGA 410
Cdd:cd17371 336 AQG-----FCYNVGRIIGAlfpFLVGFLATSGSLGTAIAVFAAVYYIAGLVLA 383
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
58-408 |
3.16e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 58.32 E-value: 3.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 58 PILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVT---ALMLASVCTLLSTmmTSWHGILVMRAL 134
Cdd:cd17370 20 SILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIlgyGLSALAKPLLALA--GSWQLVLLLRIL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 135 IGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFN----WRIALAVIGCFALASALMFWK 210
Cdd:cd17370 98 ERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGgnyrTIFLLAAIPALLALLILLFVV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 211 ILPEsrhfRPTSLRPKTLFINFRlhwrdqGLPRLFLtGFLLMGSFVTLFNY----IGYRLMLSPWHLSQAlVGLLSVAYL 286
Cdd:cd17370 178 KEYP----RPPKLRKKSKKTSLK------KLPKAFW-LYLLAVALFALGNFsfafLILRAQELGLSAALI-PLLYALFNL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 287 TGTWSSPKAGAMTARFGRGPVMLVSTAVMLFG-LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRAR-RAKGQAS 364
Cdd:cd17370 246 VYALAAYPAGRLSDRIGRKKLLILGYLSLALAyLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPaELRGTAY 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 515953973 365 SLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGF-IALMLCAALLV 408
Cdd:cd17370 326 GLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFsAVLALIALLLL 370
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
60-392 |
1.14e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 56.43 E-value: 1.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 60 LPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSL 139
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 140 SGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWR---IALAVIGCFALASALMfwkilpesr 216
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRwifYINLPIGILALLLAPL--------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 217 hfrptsLRPKTLFI-NFRLhwrdqGLPRLFLTGFLLMGSFVT----LFNYIGYRLMLSPWHL-SQALVGLLsvayltgtw 290
Cdd:cd17503 170 ------LDLRLFKDrNFTL-----GLLLSFLLGLGLFGAMFLlplyLQNVLGYSAFESGLVLaPGGLASAI--------- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 291 SSPKAGAMTARFGRGPVMLVSTAVMLFGLLMTLF----SSLWLIFAGMLLFSAGFFAAHSVASSW-IGPRARRAKGQASS 365
Cdd:cd17503 230 LSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltpdTSLWLIILPLFIRGLGMGLVFMPLNTLaLNSLPPEQIGDATA 309
|
330 340
....*....|....*....|....*..
gi 515953973 366 LYLFSYYLGSSIAGTLGGVFWHNYGWN 392
Cdd:cd17503 310 LFNTIRQLGGSIGTALLATLLTNRTQF 336
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
86-215 |
1.26e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 53.42 E-value: 1.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 86 AIGLLFTGPLS----DAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAF 161
Cdd:TIGR00880 8 ALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGV 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 515953973 162 SMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPES 215
Cdd:TIGR00880 88 ALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
59-219 |
1.80e-08 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 56.24 E-value: 1.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 59 ILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLS 138
Cdd:PRK03893 42 VLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 139 LSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRiALAVIGCFALASALMFWKILPESRHF 218
Cdd:PRK03893 122 MAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWR-ALFFIGILPIIFALWLRKNLPEAEDW 200
|
.
gi 515953973 219 R 219
Cdd:PRK03893 201 K 201
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
60-408 |
4.80e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.59 E-value: 4.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 60 LPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSL 139
Cdd:cd17312 26 KPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 140 SGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILpesrHFR 219
Cdd:cd17312 106 SMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFL----RDS 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 220 PtslrpktlfinfrlhwrdqglPRLFLTGFLLMgsFVTLFNYIgyRLMLSPWHLSQ----------ALVGLLSVAYLTGT 289
Cdd:cd17312 182 P---------------------PYVWVLSLAYA--FVYIVRYA--CLDWGPLYLYEvkgyslidagWFSSLYEVGGIAGT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 290 WSSPKAGAMTARFGRGPVMLVSTAVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSV------ASSWIGPraRRAKGQA 363
Cdd:cd17312 237 ILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPInliggaAAQDIGR--KEAAGTA 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 515953973 364 SSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFIALM-LCAALLV 408
Cdd:cd17312 315 TGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAaLLSVLLL 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
157-392 |
5.10e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.52 E-value: 5.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 157 SFVAFSMGLYISGNSIGGMSGRLLSGVF--TDFFNWRIALAVIGCFALASALMFWKILPESRHFRPTslrPKTLFINFRL 234
Cdd:COG2211 147 RLSSWRFAFAGLGGLLASVLPPPLVAAFggDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE---KVSLKESLKA 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 235 HWRDQGLpRLFLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQALVGLLSVAY-LTGTWSSPKAGAMTARFGRGPVMLVSTA 313
Cdd:COG2211 224 LLKNRPF-LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYfLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 314 VMLFGLLMTLF---SSLWLIFAGMLLFSAGFFAAHSVASSWIGPRA--------RRAKGQASSLYLFSYYLGSSIAGTLG 382
Cdd:COG2211 303 LAALGLLLLFFlgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktgRRREGLYFGIFTFAIKLGQALAGALA 382
|
250
....*....|
gi 515953973 383 GVFWHNYGWN 392
Cdd:COG2211 383 GLLLALFGYV 392
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
90-412 |
6.55e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 6.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 90 LFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAA-----VGMTYLSEEIHPSFVAFSMG 164
Cdd:cd06173 52 PFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASaffgpARQALLPELVPKEQLVRANA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 165 LYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASA--LMFWKILPESRHFRPTSLRPKTLFINFRLHWRDQGLP 242
Cdd:cd06173 132 LNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSAllLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLR 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 243 RLFLTG---FLLMGSFVTLFNYIGYR-LMLSPWHLSQAL----VGLLSVAYLTGTWSSpkagamtaRFGRGPVMLVSTAV 314
Cdd:cd06173 212 LLLLALalfALLGGALTVLLPLLAKEvLGGGAAGYGLLLaafgVGALLGALLLGRLSK--------RRRRGRLLLIGALL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 315 M-LFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRARRAK-GQASSLYLFSYYLGSSIAGTLGGVFWHNYGWN 392
Cdd:cd06173 284 LgLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELrGRVFSVYNALNSGAMPLGALLAGLLADALGLS 363
|
330 340
....*....|....*....|
gi 515953973 393 GVGGFIALMLCAALLVGASL 412
Cdd:cd06173 364 AVFLLAGALLLLAALLLLLL 383
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
27-248 |
7.02e-08 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 54.06 E-value: 7.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 27 FIKRGTPQFMRVTLAL--FSAGLATfallYCVQPILPVLSHEFG--VSPASSSISLSISTGMLAIGLLftGPLSDAIGRK 102
Cdd:PRK15403 8 FARHAATLFFPMALILydFAAYLTT----DLIQPGIINVVRDFNadVSLAPASVSLYLAGGMALQWLL--GPLSDRIGRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 103 QVMVTALM---LASVCTLLSTMMTSWhgiLVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRL 179
Cdd:PRK15403 82 PVLITGALiftLACAATLFTTSMTQF---LIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPL 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515953973 180 LSGVFTDFFNWRIALAVIGCFALASALMFWKILPESRHFRPTSLRPKTLFINFRLHWRDqglpRLFLTG 248
Cdd:PRK15403 159 SGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRN----RLFLTG 223
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
56-407 |
7.84e-08 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 54.17 E-value: 7.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 56 VQPILPVLSHEFGVSPASSSISLsisTGMLAIGLLF---TGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMR 132
Cdd:PRK15402 32 IQPGMLAVVEDFNAGAEWVPTSM---TAYLAGGMFLqwlLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLR 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 133 ALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKIL 212
Cdd:PRK15402 109 FLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAM 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 213 PESRHFRPTSLRPKTLFINFRLHWRDqglpRLFLTGFLLMGsFVT--LFNYIGyrlmLSPWHLSQALvGLLSVAYltGTW 290
Cdd:PRK15402 189 PETAGRVGEKLSLKELGRDYKLVLKN----RRFVAGALALG-LVSlpLLAWIA----LSPVILISGE-QLSSYEY--GLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 291 SSPKAGAMTA------------------RFGRGPvMLVSTAVMLFGLLMTLFSSLWLIfAGMLLFSAGFFAAHSVASSWI 352
Cdd:PRK15402 257 QVPVFGALIAgnltlarltsrrplrsliRMGLWP-MVAGLLLAALATVISSHAYLWLT-AGLSLYAFGIGLANAGLYRLT 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 515953973 353 GPRARRAKGQASSlylfSYYLGSSIAGTLGG-VFWHNYGWNGVGGFIALMLCAALL 407
Cdd:PRK15402 335 LFSSDVSKGTVSA----AMGMLSMLIFTVGIeLSKHAYLGGGNGLFNLFNLANGLL 386
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
84-361 |
1.67e-07 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 53.15 E-value: 1.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 84 MLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGI--------LVMRALIGLSLSGVAAVGMTYLSEEIH 155
Cdd:cd17368 52 MRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATIgiaapllvLLARLLQGFAAGGEVGGVTAYLVEAAP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 156 P-------SFVAFSMGLyisGNSIGGMSGRLLSGVFT----DFFNWRIALAvIGCFALASALMFWKILPESRHFRPTSLR 224
Cdd:cd17368 132 PgrrgfytSWQSASQQV---AIVAGALVGYLLSLTLTaealAEWGWRIPFF-IGLLIIPLGLWLRRSLEETEAFLERKAR 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 225 PKT--LFINFRLHWRdqglprLFLTGFLLMGSFVTLFNYIGYrlMLSPW-----HLSQALVGLLS-VAYLTGTWSSPKAG 296
Cdd:cd17368 208 PTRreLFALLANNRR------IILLGMLLVAGSTVTFYFTTV--YTPTYaktvlGLSARDSFLVTlLAGVANFIWAPLGG 279
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515953973 297 AMTARFGRGPVMLVSTAvmlfGLLMTLFSSLWLIFA----GMLL--------FSAGFFAAHSVASSWIGPRARRAKG 361
Cdd:cd17368 280 ALSDRIGRRPVLLVITL----AALVTLYPVFAWLTAapsfGRLLlvllvlsfFFGMYGGAMVVALVELFPVRVRSTG 352
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
61-222 |
3.73e-07 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 51.89 E-value: 3.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 61 PVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLS 140
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 141 GVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPESRHFRP 220
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQ 198
|
..
gi 515953973 221 TS 222
Cdd:PRK11551 199 AA 200
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
57-408 |
6.98e-07 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 51.07 E-value: 6.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 57 QPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSwhgilvmraLIG 136
Cdd:cd17331 20 QPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASS---------VPM 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 137 LSLSGVAAVGM-------TYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFW 209
Cdd:cd17331 91 LFLSRLPSVFMhamqaaqMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 210 KILPES-----RHFRPTSLRPKTLFIN--FRLHWRDQGLPRLFLTGFLL---MGSFVTLFNYIgyrlMLSPWHLSQALVG 279
Cdd:cd17331 171 LLIPSNtkskrEKEAKESASPPSVFNLkeILRLLRLPGVAFLLLVKLLSglpIGMFQSMFSLV----AMDFFGLTPEENG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 280 -LLSVAYLTGTWS-SPKAGAMTARFGRGPVMLVSTAVMLFG-LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRA 356
Cdd:cd17331 247 yLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGyLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 515953973 357 RRA-KGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVG---GFIALMLCAALLV 408
Cdd:cd17331 327 PPEdTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGllgAAINGLLTVYLLL 382
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
86-218 |
7.58e-07 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 51.12 E-value: 7.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 86 AIGLLFTGPLSDAIGRKQVMVTA---LMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFS 162
Cdd:pfam00083 60 FIGSLFAGKLGDRFGRKKSLLIAnvlFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGAL 139
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 515953973 163 MGLYISGNSIGGMSGRLLSGVFTDFFN---WRIALAVIGCFALASALMFWKiLPESRHF 218
Cdd:pfam00083 140 GSLYQLAITFGILLAYIFGLGLNKTSNsdgWRIPLGLQLVPALLLIIGLLF-LPESPRW 197
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
87-408 |
1.24e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.30 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 87 IGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPS--FVAFSMg 164
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPEnrTRAFSL- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 165 LYISGNsIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKiLPESRHFRPTSlRPKTLFINFRLHWRDQGLPRL 244
Cdd:cd17329 129 LYWAIN-LGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFL-LPETRPKRRAA-EKTEILRGYKIVLRDRAFLLF 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 245 FLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQALVGLLSVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFGLLMTLF 324
Cdd:cd17329 206 LLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAF 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 325 S-SLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-RRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGV-GGFIALM 401
Cdd:cd17329 286 AnTLAVLILAMIVLTLGEMLVFPAVQTLVAALApPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPwLILAALG 365
|
....*..
gi 515953973 402 LCAALLV 408
Cdd:cd17329 366 LIAAALL 372
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
272-417 |
1.43e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 49.87 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 272 HLSQALVGLL-SVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFG-LLMTLFSSLWLIFAGMLLFSAGFFAAHSVAS 349
Cdd:COG2807 49 GLSATQAGLLtTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGlLLRSLAPSVALLLAGTALIGAGIAVGNVLLP 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515953973 350 SWIGPRARRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFIALMLCAALLVGASLHKRLH 417
Cdd:COG2807 129 GLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP 196
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
243-410 |
3.01e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.82 E-value: 3.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 243 RLFLTGFLLMGSFVTLFNYIGYRLMLSP----WHLSQALVGLLSVAY-LTGTWSSPKAGAMTARFGRGPVMLVSTAVMLF 317
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLiaadLGASPAQAGLVVTAYlLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 318 GLLMTLFS-SLWLIFAGMLLFSAGFFAAHSVASSWIGPRARRAK-GQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVG 395
Cdd:COG2814 88 GSLLCALApSLWLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170
....*....|....*
gi 515953973 396 GFIALMLCAALLVGA 410
Cdd:COG2814 168 LVNAVLALLALLLLL 182
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
244-417 |
3.49e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.74 E-value: 3.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 244 LFLTGFLLMGSFVTLFNYIGyrLMLSPWHLSQALVGLLSVAYLTGTWSS-PKAGAMTARFGRGPVMLVSTAVMLFGLLMT 322
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLP--LYAHDLGGSEAVAGLVVGLFTLAALLArPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 323 LFS-SLWLIFAGMLLFSAGFFAAHSVASSW---IGPRARRakGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFI 398
Cdd:cd17489 79 LLAtSVALLLVLRLIHGIGWGAFTTAAATLvadIIPPSRR--GEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170
....*....|....*....
gi 515953973 399 ALMLCAALLVGASLHKRLH 417
Cdd:cd17489 157 AVLALLALLLVFLVKDPPP 175
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
33-174 |
4.46e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.43 E-value: 4.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 33 PQFMRVTLALFSAGLATFALLYCVQPIlpvLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLA 112
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLY---LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515953973 113 SVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGG 174
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
58-340 |
5.04e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 48.36 E-value: 5.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 58 PILPVLSHEFGVSPASSSISLSIStgMLAIGL--LFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALI 135
Cdd:PRK11652 29 PAIADMARDLNVREGAVQAVMAAY--LLTYGLsqLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQ 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 136 GL--SLSGVAAVGMT---YLSEEIHPSFVAFSMGLYISgnsigGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWK 210
Cdd:PRK11652 107 GLgtGVGGVMARTLPrdlYEGTQLRHANSLLNMGILVS-----PLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 211 ILPESrhfRPTSLRPKTLFINFRLHWRDQGLPRLFLtgfLLMGSF--VTLFNYIGYRLMLSPWHLSQALVGLLSV----A 284
Cdd:PRK11652 182 WMPET---RPADARRTRVLASYRTLLSNRRFNCYLL---MLIGTLagIAVFEACSGVLMGAVLGLSSMTVSILFIlpipA 255
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515953973 285 YLTGTWSspkAGAMTARFGRgpVMLVSTAVMLFGLLMTLFSSLW--------LIFAGMLLFSAG 340
Cdd:PRK11652 256 AFFGAWF---AGRPNKRFST--LMWQSVICCLLAGLLMWIPGWFgvmnvwtlLVPAALFFFGAG 314
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
90-407 |
5.82e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 47.93 E-value: 5.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 90 LFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSwHGILVMraLIGLSLSGVAAVGMTYL-------SEEIHPSFVAFS 162
Cdd:cd17471 50 QWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLR-NYWVLL--LVGVVLLSLGAAAFPQLfalareyADRSSGRDATLF 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 163 MGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPESRHFRPTSLRPKTlfinfRLHWRDQGLP 242
Cdd:cd17471 127 NSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASS-----LVKAPVNRRL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 243 RLFLTGFLLMgsFVTLFNYIGYR--LMLSPWHLSQALVGLL-SVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAV-MLFG 318
Cdd:cd17471 202 LLLFAAFTLL--FAANSMYIIAMplYVTNELGGSESWVGLLfGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAgVLFY 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 319 LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRARRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFI 398
Cdd:cd17471 280 LGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVC 359
|
....*....
gi 515953973 399 ALMLCAALL 407
Cdd:cd17471 360 AVLALLALV 368
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
86-216 |
1.63e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 46.80 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 86 AIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFvafsMGL 165
Cdd:cd17315 48 AIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKI----RGA 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 515953973 166 YISGNSIGGMSGRLLSGVFTDFF------NWRIALAVIGCFALASALMfWKILPESR 216
Cdd:cd17315 124 LGTLNQLMITFGILLAYLLGLALslsppgWWRLMFALAAVPALLQLLL-MFFLPESR 179
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
87-227 |
2.60e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 46.07 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 87 IGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLY 166
Cdd:PRK12307 68 FGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFL 147
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515953973 167 ISGNSIGGMSGRLLSGVFTDFFNWRIALaVIGCFALASALMFWKILPESRHFRPTSLRPKT 227
Cdd:PRK12307 148 VSGFGIGNIIAAYFMPSFAEAYGWRAAF-FVGLLPVLLVIYIRARAPESKEWEEAKLSGKG 207
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
86-231 |
3.04e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 46.10 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 86 AIGLLFTGPLSDAIGRKQVMV---TALMLASVCTLLSTMMTSWHGILVMRALIGLSLS-GVAAVGMtYLSeEIHPSFVAF 161
Cdd:cd17357 63 AIGSFISAFLANRFGRKNGLLisnALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGlSTGFVPM-YLQ-EISPSELRG 140
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515953973 162 SMGLYisgNSIGGMSGRLLSGVFT------DFFNWRIALAVIGCFALASALMFWkILPESrhfrptslrPKTLFIN 231
Cdd:cd17357 141 ALGSL---TQIGVTLGILLGQVFGlpsvlgTETLWPYLLFFPGIPALLQLAALP-FFPES---------PKFLLIS 203
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
42-216 |
3.14e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 45.69 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 42 LFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTM 121
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 122 MTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFF-NWRIALAVIGCF 200
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVL 163
|
170
....*....|....*.
gi 515953973 201 ALASALMFWKILPESR 216
Cdd:cd17328 164 GVLLAILLLLFVREPP 179
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
90-209 |
4.63e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 45.28 E-value: 4.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 90 LFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISG 169
Cdd:cd17489 245 PFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIF 324
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 515953973 170 NSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFW 209
Cdd:cd17489 325 FDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
19-209 |
5.52e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 5.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 19 PAAPQPVQFIKRGTPQFMRVTLALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDA 98
Cdd:cd17370 181 PRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDR 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 99 IGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGR 178
Cdd:cd17370 261 IGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLAS 340
|
170 180 190
....*....|....*....|....*....|.
gi 515953973 179 LLSGVFTDFFNWRIALAVIGCFALASALMFW 209
Cdd:cd17370 341 LIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
85-211 |
5.67e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.88 E-value: 5.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 85 LAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMG 164
Cdd:cd17317 38 VLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGI 117
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 515953973 165 LYISGNSIGGMsgrLLSGVFTDFFNWRIALAVIGCFALASALMFWKI 211
Cdd:cd17317 118 LFGLFWALGYM---LLALLAYLIRDWRWLQLAISLPGLLFLLLLWWL 161
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
245-408 |
6.17e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 6.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 245 FLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQALVGLLSVAY-LTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFGLLMTL 323
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFsLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 324 F-SSLWLIFAGMLLFSAGFFAAHSVASSWIGPRA-RRAKGQASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFIALM 401
Cdd:pfam07690 81 FaSSLWLLLVLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
....*..
gi 515953973 402 LCAALLV 408
Cdd:pfam07690 161 SLLAAVL 167
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
82-209 |
6.57e-05 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 44.59 E-value: 6.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 82 TGMLAIGLLFtGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAF 161
Cdd:cd17374 46 AGLLVGALIF-GHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRAL 124
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 515953973 162 SMGLYISGNSIGGMsgrLLSGVFTDFFNWRIALAVIGCFALASALMFW 209
Cdd:cd17374 125 AITLTSCFFSIGQM---LLAGLAYAIRDWRLLQLVVSVPFFLFFLYSW 169
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
87-410 |
6.64e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.83 E-value: 6.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 87 IGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGI--------LVMRALIGLSLSGVAAVGMTYLSEEIHPSf 158
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQIgilapillVLLRLLQGLALGGEWGGAVLMAVEHAPPK- 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 159 vafSMGLYISGNSIGGMSGRLLS-GVF--------TDFFN---WRIAlavigcFALASALMFWKI-----LPESRHFRPT 221
Cdd:cd17369 138 ---RRGFYGSFPQLGAPVGLLLAtGVFlllsallsDEAFLswgWRIP------FLLSAVLVAVGLyirlrLEETPVFRRA 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 222 SLRPKTLFINFRLHWRDQglPRLFLTGFLLMGSFVTLFnYIGYRLMLSpwHLSQAL-------VGLLSVAYLTGTWSSPK 294
Cdd:cd17369 209 KEAGQVVRAPLVEVLRRH--WRALLLAIGLRLAENVLF-YLFTTFALS--YATQTLgvdrstvLLAVLIASVVAAITIPL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 295 AGAMTARFGRGPVMLVST-AVMLFG----LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWI----GPRARrakgqass 365
Cdd:cd17369 284 FGWLSDRVGRRPVYLAGAlLAALFAfpffWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLaelfPTRVR-------- 355
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 515953973 366 lylfsyYLGSSIAGTLGGVfwhnygwngVGGFIALMLCAALLVGA 410
Cdd:cd17369 356 ------YTGASLGYQLGAI---------LGGGFAPLIATALVAAT 385
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
58-208 |
6.92e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 44.87 E-value: 6.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 58 PILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGL 137
Cdd:cd17323 20 PALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGF 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515953973 138 SLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWR----IALAVIGCFALASALMF 208
Cdd:cd17323 100 FGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRwifwFLAIISGFCLILIFLFL 174
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
60-209 |
6.98e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 6.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 60 LPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMrALIGLSL 139
Cdd:cd17478 218 LPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLL 296
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515953973 140 SGVAAVGMTYlSEEIHPSFVAFSMGLYIS-GNSIGGMsGRLLSGVFTDFFNWRIALAVIGCFALASALMFW 209
Cdd:cd17478 297 FASFPVTVVL-AQELLPGNVGLASGLMMGlSFGLGGI-GAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
90-209 |
7.17e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 7.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 90 LFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIhPSFVAFSMGLYISG 169
Cdd:cd17471 253 LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLM-PGQPGLATTLYSNA 331
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 515953973 170 NSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFW 209
Cdd:cd17471 332 SRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
32-207 |
8.25e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.52 E-value: 8.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 32 TPQFMRVTLALFsagLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALML 111
Cdd:cd17353 212 TPTFWLLWLMFF---LNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLI 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 112 ASVCTLLSTMMTSWHGI-LVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNW 190
Cdd:cd17353 289 QGVAMFLLPFIGSVAVLfVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGY 368
|
170
....*....|....*..
gi 515953973 191 RIALAVIGCFALASALM 207
Cdd:cd17353 369 NAAFIIAAALSLVALAL 385
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
37-211 |
9.33e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 9.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 37 RVTLALFSAGLATFALLYCVQPILP-VLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDA-IGRKQVMVTALMLasv 114
Cdd:cd17474 198 RGLLTFLVSAFLYFFLYFAFLTYLPfLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLL--- 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 115 CTLLSTMMTSWHGILVMraLIGLSLSGVA-----AVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFN 189
Cdd:cd17474 275 YALSLLLLGFVPSLALL--LIAIVLFGLGlglnlPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
|
170 180
....*....|....*....|..
gi 515953973 190 WRIALAVIGCFALASALMFWKI 211
Cdd:cd17474 353 LSAPFLVGAAIALAAAVLLALL 374
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
42-343 |
1.21e-04 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 43.93 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 42 LFSAGLATFAL---LYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLL 118
Cdd:PRK10091 5 ILSLALGTFGLgmaEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 119 STMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIG 198
Cdd:PRK10091 85 FTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 199 CFALASALMFWKILPESRHFRPTSLRPKTLFINFRLHWrdqglpRLFLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQALV 278
Cdd:PRK10091 165 VFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPW------LIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMT 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515953973 279 GLLSVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFGLLMTLFSS--LWLIFAGMLLFSAGFFA 343
Cdd:PRK10091 239 FIMMLVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLMLFFFGgmKTASLIFAFICCAGLFA 305
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
157-383 |
1.23e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.13 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 157 SFVAFSMGLYISGNSIGGMSGRLLSGVFTD---FFNWRIALAVIGCFALASALMFWKILPESRHFRPTSLRPKTLFINFR 233
Cdd:cd17332 136 SLTSWRMFFATIGGLLVTVLPPPLVAYFGGgnaSRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLK 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 234 LHWRDQGLPRLFLTGFLLMGSFVTLFNYIGY---RLMLSPWHLSQALVGLLSVAYLTGTWSSPKagamTARFGRGPVMLV 310
Cdd:cd17332 216 ALLKNRPFLILLLAYLLYFLAFNIVNTVLVYyfkYVLGGRAELVLLLLLILSGALLALLPWPPL----KKRFGKKKAFFI 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 311 STAVMLFGLLMTLF---SSLWLIFAGMLLFSAGFFAAHSVASSWIG--------PRARRAKGQASSLYLFSYYLGSSIAG 379
Cdd:cd17332 292 GLLLAILGLLLLFFlppGNLVLILVLAVLAGIGYGGANLLPWAMLAdvidygelKTGKRREGIFYSVMTFFRKLGLALAG 371
|
....
gi 515953973 380 TLGG 383
Cdd:cd17332 372 ALVG 375
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
35-340 |
1.31e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.78 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 35 FMRVTLALFSAGLATfallycVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGP----LSDAIGRKQVMVTALM 110
Cdd:cd17388 3 FILVTVLLDAMGIGL------IMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 111 LASVCTLLSTMMTSWHGILVMRALIGLSlSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDfFNW 190
Cdd:cd17388 77 GAALDYLLMAFAPTLWWLYLGRIIAGIT-GATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 191 RIALAVIGCFALASALMFWKILPESRH------FRPTSLRPktlFINFRLHWRDQGLPRLFLTGFLLMGS----FVTLFN 260
Cdd:cd17388 155 RAPFLVAAGLNGLNFLLGLFVLPESLPperrraFRWRRANP---FGSLRWLTGFPGLLGLLAVFFLIQLIgqvpATTWVL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 261 YIGYRLMLSPWH--LSQALVGLLSVAYLTGTwsspkAGAMTARFG-RGPVMLVSTAVMLFGLLMTLFSSLWLIFAGMLLF 337
Cdd:cd17388 232 FTEDRFDWSPTMvgLSLAVFGLLHALFQAFV-----TGPIAKRLGeKRAILLGLAADALGFLLLAFATQGWMVFPILILL 306
|
...
gi 515953973 338 SAG 340
Cdd:cd17388 307 ALG 309
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
36-211 |
1.45e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.76 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 36 MRVTLALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVC 115
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 116 TLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALA 195
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
170
....*....|....*.
gi 515953973 196 VIGCFALASALMFWKI 211
Cdd:cd06173 368 LAGALLLLAALLLLLL 383
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
190-414 |
1.47e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 44.14 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 190 WRIALAVIGCfALASALMFWKI--LPES---RHFRPTSLRPKTLFINFRLHWRDQGLpRLFLTG---FLLMGSFVTLfNY 261
Cdd:PRK08633 179 APAGLVLLAV-AVLGLIFAYRLpkVPAAapeVFDKKKYLFPKLLWRNLKLLRSDRVL-WLAIIGlsyFWFISQLAQA-NF 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 262 IGY---RLMLSPWHLSQALVGLLSVAYLTGtwsSPKAGAMTAR---FGRGPVMLVSTAVMLFglLMTLFSSLWLIFAGML 335
Cdd:PRK08633 256 PAYakeVLGLDNTFQVQYLLAASAIGIGIG---SLLAGRLSGRhieLGLVPLGALGLALSLF--LLPTAPSLASVLVLFF 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 336 LF--SAGFFaahSVA-SSWIGPRARRA-KGQ---ASSLYLFSYYLGSSIAGTLggvfWHNYGWNGVGGFIALMLCAALLV 408
Cdd:PRK08633 331 LFgfSAGLF---IVPlNALIQFRAPEKeLGKvlaANNFLQNVGMLLFLALTTL----FSGLGLSPAGLFYLIALVTLIGT 403
|
....*.
gi 515953973 409 GASLHK 414
Cdd:PRK08633 404 LYTLLL 409
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
113-381 |
1.59e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 43.78 E-value: 1.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 113 SVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLS-GVFT-----D 186
Cdd:cd17327 82 GLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAyGVFKilgvgG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 187 FFNWRIALAVIGCFALASALMFWKILP------------ESRHFRPTSLRPKTLFINFRLHWRDQGL----PRLFLTGFL 250
Cdd:cd17327 162 LAGWRWLFIIEGLITIIIGLVIFFWLPdnpskawflteeEKELAVERLRANQTGKGDQKFKWKQIKEafkdPRTWLLFLF 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 251 LMGSFVTLFNYIGYR-LMLSPWHLSQALVGLLSVA-YLTGTWSSPKAGAMTARF-GRGPVMLVSTAVMLFGLLMTLFSSL 327
Cdd:cd17327 242 FFCSQITNNGISNFLpLILKSLGFYSLQTNLLSVPiGALGAVSLLIAALLSDRFkKRGLFAIFACVLALVGSIILLAAPN 321
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 515953973 328 -WLIFAGMLLFSAGFFAAHSVASSWIGPRAR--RAKGQASSLYLFSYYLGSSIAGTL 381
Cdd:cd17327 322 pPGAYFAAYILGGGSYAGFPILLSWISSNCAgyTKRATVLAIMLIFYNVGNIVAPQI 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
37-209 |
1.87e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.31 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 37 RVTLALFSAGLATFALLYCVQPIL-PVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVC 115
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLaPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 116 TLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEeIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALA 195
Cdd:cd17324 278 LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
|
170
....*....|....
gi 515953973 196 VIGCFALASALMFW 209
Cdd:cd17324 357 VGAALLLLALLLAL 370
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
39-412 |
2.39e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.01 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 39 TLALFSAGLATFALlycvQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLL 118
Cdd:cd17341 5 WLSFFLGFMVWFLF----APLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 119 STM-MTSWHGILVMRALIGLSLsGVAAVGMTYLSEEIHPS-FVAFSMGLYISGNSIGGMSGRLLSGVF------TDFFNW 190
Cdd:cd17341 81 LALaVSSYWGLLVLGFLLGFAG-ANFASGQPWASFWFPKEkIGGAAGGIAGAGNMGVAVSQLLAPLIAgaivfdGGFVGW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 191 RIALAVIGCFALASALMFW---KILPESRHFRPTSLRPKTLFINFRLHWrdqglpRLFLTGFLLMGSFVTLFNYIG---- 263
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVLlfgDDLPTGKASALEFLKVQLAVLKNYRTW------ILSLLYGVTFGSFVGFSNVLPtyfk 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 264 --YRLMLSPWHLSQALVGLL-SVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFgLLMTLFSSLWLIFAGMLLFSAG 340
Cdd:cd17341 234 trFGLPLVTAGILAALFPLAgALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSL-SLPTSGTNLVLFLALFVALGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515953973 341 FFAAHSVASSWIGPRARRAKGQASSLylfsyylgSSIAGTLGG-----VFWHNYGWNGVgGFIALMLCAALLVGASL 412
Cdd:cd17341 313 AGAGNGSVFRMVPFIFRRELGAVTGL--------VGAIGGLGGfflplLFGSSALMTGS-GVGAFSLFGVLAVACTL 380
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
82-207 |
4.10e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.31 E-value: 4.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 82 TGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIhPSFVAF 161
Cdd:cd17333 245 WVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNL-PYAKGK 323
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 515953973 162 SMGLYISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALM 207
Cdd:cd17333 324 GTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
86-406 |
4.21e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 42.17 E-value: 4.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 86 AIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPS----FVAF 161
Cdd:cd17502 44 TAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRergkYQGY 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 162 SMGLYisgnSIGGMSGRLLSGVFTDFFNWR-----------IALAVIGCFALASALMfwkilpesrhfrptslrpktlfi 230
Cdd:cd17502 124 IGAVF----GIASVAGPLIGGAFTDHLSWRwcfyinlpiggLALALLRTILLSSIFG----------------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 231 nfrlhwrdqglprlFLTGFLLMGSFVTLFNYIGYRLMLSPWHLSQALVGLLSVAYLTGTWSspkaGAMTARFGR-GPVML 309
Cdd:cd17502 177 --------------FLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIIS----GALISKTGRyKPLIV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 310 VSTAVMLFG----LLMTLFSSLWLIFAGMLLFSAGF---FAAHSVASSWIGPRARRAKGQASSlylfsyYLGSSIAGTLG 382
Cdd:cd17502 239 IGTILMSVGagllTTLTLDTSKWLLIGYLILLGLGLgigFQQPLVAVQNAVPPADVGVATATN------TFFRSLGGTLG 312
|
330 340
....*....|....*....|....
gi 515953973 383 GVFWHNYGWNGVGGFIALMLCAAL 406
Cdd:cd17502 313 VAITDVFLVALALAALAFLLSLFL 336
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
50-414 |
7.61e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.42 E-value: 7.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 50 FALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRkqvMVTALMLASVCTLLSTMMTSW-HGI 128
Cdd:cd17335 10 FAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGK---RKALLLLSLLAAVLFFLSLFFvAQI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 129 LVMRALIGLSLSGVAAVGMTyLSEEIHPSFVAFSMGLY---ISGNSIGGMSGRLLSGVFTDffNWRIALAVIGCFALASA 205
Cdd:cd17335 87 FWLLLLLVILGAFFSAPVVP-LVDSITLQYLGEERERYgkqRLWGSIGFGIAALLVGILID--RSSTYKNYTIAFYVFAV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 206 LMFWKILPESR-HFRPTSLRPKTLFINFRLHWRDQGLPRLFLTGFLLMGSFVTLFNYigyrlmlSPWHL-----SQALVG 279
Cdd:cd17335 164 LMLLALLLALKfPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSF-------LFWHLqdlggSKTLIG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 280 LLS-VAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFG-LLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIG---P 354
Cdd:cd17335 237 LLWtVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRwLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASaaaP 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 355 RARRAKGQASsLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGGFIALMLCAALLVGASLHK 414
Cdd:cd17335 317 PGLRATAQGL-LQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
83-218 |
7.95e-04 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 41.89 E-value: 7.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 83 GMLaIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEI-------H 155
Cdd:TIGR01299 214 GMM-VGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLaqekrgeH 292
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515953973 156 PSFVA-FSM--GLYISGNS---IGGMSGRLLSGVFTDFFNWRIaLAVIGCFALASALMFWKILPESRHF 218
Cdd:TIGR01299 293 LSWLCmFWMigGIYAAAMAwaiIPHYGWSFQMGSAYQFHSWRV-FVIVCAFPCVFAIGALTFMPESPRF 360
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
33-209 |
9.03e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.02 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 33 PQFMRVTLALFSAGLATFALLYCVQPILpvlSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSD---AIGRKQVMVTAL 109
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYL---KQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 110 MLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFF- 188
Cdd:cd17319 256 LLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATg 335
|
170 180
....*....|....*....|.
gi 515953973 189 NWRIALAVIGCFALASALMFW 209
Cdd:cd17319 336 SYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
38-207 |
1.00e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.00 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 38 VTLALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTL 117
Cdd:cd17352 4 VVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 118 LSTMMTS-WHGILVMRALIGLSLsgvaavGMTYLseeihPSFVAFS----------MGLYISGNSIGGMSGRLLSGVFTD 186
Cdd:cd17352 84 LSSFATSlWQLYLTYGVLGGLGL------GLIYS-----PAIVIVGqyfekkrglaTGIAVAGSGVGTFVFPPLLRYLLD 152
|
170 180
....*....|....*....|.
gi 515953973 187 FFNWRIALAVIGCFALASALM 207
Cdd:cd17352 153 NYGWRGALLILGGLCLNLCVC 173
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
35-177 |
1.17e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 35 FMRVTLALFSAGLATFALLYCVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQ---VMVTALML 111
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLIL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515953973 112 ASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSG 177
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
86-152 |
1.39e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.63 E-value: 1.39e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515953973 86 AIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSE 152
Cdd:cd17359 50 AIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAE 116
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
50-213 |
1.89e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 40.23 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 50 FALLYCVQPILPV----LSHEFGVSPASssislsisTGML----AIGLLFT----GPLSDAIGRKQVMVTALMLASVCTL 117
Cdd:cd17380 8 TCICYADRVNMPIaivpMAKEFGWSKTD--------QGLVlssfFWGYALTqvlgGYLADRFGGKKVLLLAVALWSLATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 118 LSTMMTSWH--GILVMRALIGLsLSGVAAVGMTYL-SEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTDFFNWRIAL 194
Cdd:cd17380 80 LTPLLAYSSlpLLILSRILLGL-GEGVHFPSMTSLfSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVF 158
|
170
....*....|....*....
gi 515953973 195 AVIGCFALASALMFWKILP 213
Cdd:cd17380 159 YFFGLLGLLWALVWLIYLP 177
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
87-175 |
2.15e-03 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 39.76 E-value: 2.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 87 IGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSmgly 166
Cdd:cd17377 54 IGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVGKSYWALA---- 129
|
....*....
gi 515953973 167 isgNSIGGM 175
Cdd:cd17377 130 ---GSLGGL 135
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
86-211 |
3.08e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.75 E-value: 3.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 86 AIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGL 165
Cdd:COG2270 288 ALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGL 367
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 515953973 166 YisgnsigGMSGR-------LLSGVFTDFF-NWRIALAVIGCFALASALMFWKI 211
Cdd:COG2270 368 Y-------ALSGKaasflgpLLFGLVTQLTgSQRLGILSLIVFFVIGLVLLLRV 414
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
83-341 |
3.45e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 39.18 E-value: 3.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 83 GMLAIGLLFTGPLSDAIGRKQVmvtaLMLASVC-TLLSTMMTSWHGILVM---RALIGLSLsGVAAVGMTYLSEEIHPSF 158
Cdd:cd17360 46 AGAAVGAAIGGWLNDRFGRRPC----ILLADALfTIGAIVMAAAPNKEVLivgRVLVGLGV-GIASMTVPLYIAEAAPPR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 159 VafsMGLYISGNSIGGMSGRLLSGVFTDFFN-----WRIALAVIGCFALASA-LMFWkiLPESRHFRPTSLRpktLFINF 232
Cdd:cd17360 121 I---RGRLVTINVLFITGGQFVAYVINGAFSylpggWRWMLGLAAVPAVLQFiGLLF--LPESPRWPSTRRA---LIVGC 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 233 RLHWRDQglprlfLTGF-LLMGSFVTLFNYIGYRLMLSPWHLSQALVGLLSVAYLTGTWSspkagamTARFGRGPVMLVS 311
Cdd:cd17360 193 GLQAFQQ------FSGInTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYL-------IDKFGRRKLLLIS 259
|
250 260 270
....*....|....*....|....*....|
gi 515953973 312 TAVMLFGLlmtLFSSLWLIFAGMLLFSAGF 341
Cdd:cd17360 260 LFGVIVAL---VVLAVWLALVGLILYLAFF 286
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
87-214 |
4.66e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.82 E-value: 4.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 87 IGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMT-SWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGL 165
Cdd:cd17371 260 LGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPlSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGF 339
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 515953973 166 YISGNSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALASALMFWKILPE 214
Cdd:cd17371 340 CYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPE 388
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
93-213 |
4.67e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.14 E-value: 4.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 93 GPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWH--GILVMRALIGLsLSGVAAVGM-TYLSEEIHPSFVAFSMGLYISG 169
Cdd:cd17318 77 GYLAEKYGAKRVLGYSILITALLTLLTPLAARGGygALIVLRILQGL-AQGVTFPAMhALWAKWAPPLERSRLTSIAYSG 155
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 515953973 170 NSIGGMSGRLLSGVFTDFFNWRIALAVIGCFALA-SALMFWKILP 213
Cdd:cd17318 156 SQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLwCLLWFFLVLP 200
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
243-353 |
5.07e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 5.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 243 RLFLTGFLLMGSFVTL-FNYIgyrLMLSPWHLSQALVGL-LSVAYLTGTWSSPKAGAMTARFGRGPVMLVSTAVMLFG-L 319
Cdd:cd17329 4 LLIGSFLNRLGFFMVWpFMAI---YLHQQLGLSASIVGLvLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGfA 80
|
90 100 110
....*....|....*....|....*....|....
gi 515953973 320 LMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIG 353
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIA 114
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
53-135 |
7.21e-03 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 38.41 E-value: 7.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 53 LYCVQPILPVLSHEFGVSPASSSISLSISTGMLA-----IGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHG 127
Cdd:cd17364 15 LFSISLVTKILGRLYYGGKGSLPSGVSGLVNAAAlvgtiIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTP 94
|
....*...
gi 515953973 128 ILVMRALI 135
Cdd:cd17364 95 LGVMGWLI 102
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
83-215 |
7.69e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 38.46 E-value: 7.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 83 GMLaIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWHGILVMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFS 162
Cdd:TIGR00898 139 GVL-LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIV 217
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 515953973 163 MGLYISGNSIGGMsgrLLSGVFTDFFNWRIALAVIGCFALASALMFWkILPES 215
Cdd:TIGR00898 218 GTLIQVFFSLGLV---LLPLVAYFIPDWRWLQLAVSLPTFLFFLLSW-FVPES 266
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
56-364 |
8.86e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 37.94 E-value: 8.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 56 VQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLSTMMTSWhGILVMRALI 135
Cdd:cd17339 18 VGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIA-LLFLGTALA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 136 GLSLsGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVFTD--FFNWRIALAVIGCFALAsALMFWKILP 213
Cdd:cd17339 97 GAGI-AVGNVLLPSLIKRDFPRRVGLMTGLYTTSMNLGAALASGLSVPLAQalGGGWRGALAIWALPALL-ALLIWLPQL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 214 ESRHFRPTSLRPKTlfinFRLHWRDQ---------GLPRLFLtgFLLMGSFVTLFNYIGYRLMLSPWhlsqaLVGLLSVA 284
Cdd:cd17339 175 RRRKRAAAAAAPLT----KISVWRSPlawqvtlfmGLQSLLF--YTLMAWLPTILIDAGLSAATAGW-----LLSLFQLV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 285 YLTGTWSSPkagAMTARF-GRGPVMLVSTAVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRARRAKGQA 363
Cdd:cd17339 244 GIPASLLVP---ILATRLkNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLLGLGGGAAFSLALTLISLRSSDPAEAA 320
|
.
gi 515953973 364 S 364
Cdd:cd17339 321 A 321
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
40-208 |
9.95e-03 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 37.98 E-value: 9.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 40 LALFSAGLATFAllycVQPILPVLSHEFGVSPASSSISLSISTGMLAIGLLFTGPLSDAIGRKQVMVTALMLASVCTLLS 119
Cdd:PLN00028 43 ISFFTCFVSTFA----AAPLLPIIRDNLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCM 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953973 120 TMMTSWHGILVMRALIGLSLSGVAAvGMTYLSEEIHPSFVAFSMGLYIS-GNSIGGMSGRLLSGVF--------TDFFNW 190
Cdd:PLN00028 119 SLVSSATGFIAVRFFIGFSLATFVS-CQYWMSTMFNGKIVGTANGIAAGwGNLGGGVTQLLMPLVFplikdagaPSFTAW 197
|
170
....*....|....*...
gi 515953973 191 RIALAVIGCFALASALMF 208
Cdd:PLN00028 198 RIAFFVPGLLHIIMGILV 215
|
|
| |
