|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
12-416 |
1.02e-97 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 296.79 E-value: 1.02e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 12 TFKLIPALVILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGL 91
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 92 ITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGmdgianLH 171
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL------LF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 172 GWQWLFVAVGLPAVLLALPTFLWLPdnidkvkwlsieqkqwlknelvkdeaeydqtrhanplhalkdkRVLLLALYYLPV 251
Cdd:cd17319 155 GWRWAFIIEGLLGLLLAVLWWFYLR-------------------------------------------QVWGLALGYFGI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 252 TLSIYGLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRL--NDRYGHLSFLYALGACAMFLSAWLNSP 329
Cdd:cd17319 192 NYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTSP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 330 VMQLAALAVVAFCLFSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFG 409
Cdd:cd17319 272 VVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLA 351
|
....*..
gi 515955498 410 LILTYIV 416
Cdd:cd17319 352 ALLVLLL 358
|
|
| HpaX |
TIGR02332 |
4-hydroxyphenylacetate permease; This protein is a part of the Major Facilitator Superfamily ... |
7-407 |
1.49e-97 |
|
4-hydroxyphenylacetate permease; This protein is a part of the Major Facilitator Superfamily (pfam07690). Member of this family are found in a number of proteobacterial genomes, but only in the context of having genes for 4-hydroxyphenylacetate (4-HPA) degradation. The protein is characterized by Prieto, et al. ( as 4-hydroxyphenylacetate permease in E. coli, where 3-HPA and 3,4-dihydroxyphenylacetate are shown to competitively inhibit 4-HPA transport and therefore also interact specificially.
Pssm-ID: 131385 [Multi-domain] Cd Length: 412 Bit Score: 298.44 E-value: 1.49e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 7 VIRTVTFKLIPALVILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRIL 86
Cdd:TIGR02332 1 VIKKLFRRLIIFLFILFIFSFLDRINIGFAGLTMGKDLGLSATMFGLAATLFYAAYVICGIPSNIMLAIIGARRWIAGIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 87 LTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMDG 166
Cdd:TIGR02332 81 VLWGIASTATMFATGPESLYLLRILVGIAEAGFLPGILLYLTFWFPAYFRARANALFMIAMPVTMALGLILSGYILALDG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 167 IANLHGWQWLFVAVGLPAVLLALPTFLWLPDNIDKVKWLSIEQKQWLKNELVKDEAEYDQTRHANPLHALKDKR------ 240
Cdd:TIGR02332 161 LMALKGWQWLFLLEGFPSVILGVMTWFWLDDSPDKAKWLDEEDKKALKEMIDNDQLTLEQPEGAFAHAAMPQRSmlreif 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 241 ---VLLLALYYLPVTLSIYGLNLWLPTIIKQFG-GGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGHLSFLYALG 316
Cdd:TIGR02332 241 tpaIMLYTLAYFCLTNTLSAINIWTPQILQSFNqGSSNIMIGLLAAIPQFCTIFGMIWWSRHSDRLKERKHHTALPYLFA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 317 ACAMFLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMA 396
Cdd:TIGR02332 321 AAGWLLASATDHNLIQLLGIIMASMGSFSAMAIFWTTPDQSISLQARAIAIAVINATGNIGSALSPFLIGILKDATGSFN 400
|
410
....*....|.
gi 515955498 397 AGLYFLSIVML 407
Cdd:TIGR02332 401 SGLWFVAALLV 411
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
21-416 |
1.18e-84 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 264.58 E-value: 1.18e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 21 ILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQ 100
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 101 GPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMdgianlHGWQWLFVAV 180
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIH------FSWQWAFIIE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 181 GLPAVLLALPTFLWLPDNIDKVKWLSIEQKQWLKNELVKDEAEY--DQTRHANPLHALKDKRVLLLALYYLPVTLSIYGL 258
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKgpSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 259 NLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGHLSF-------LYALGACAMFLSAWLNSPVM 331
Cdd:TIGR00893 235 LTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFarktaiiAGLVLSLLMFATNYVNIPYA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 332 QLAALAVVAFCLfSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLI 411
Cdd:TIGR00893 315 ALALVALGFFGL-GAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGAL 393
|
....*
gi 515955498 412 LTYIV 416
Cdd:TIGR00893 394 SYLLL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
5-422 |
3.77e-68 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 220.90 E-value: 3.77e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 5 KDVIRTVTFKLIPALVILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTR 84
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 85 ILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLgm 164
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 165 dgiaNLHGWQWLFVAVGLPAVLLALPTFlwlpdnidkvkwlsieqkqwlknelvkdeaeydqtrhanplhalkdkrvLLL 244
Cdd:COG2271 159 ----AAFGWRAAFLILGLPGLLLALLRF-------------------------------------------------WLL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 245 ALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYG-HLSFLYALGACAMFLS 323
Cdd:COG2271 186 ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLLLAALALLLL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 324 AWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGnMAAGLYFLS 403
Cdd:COG2271 266 ALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLA 344
|
410
....*....|....*....
gi 515955498 404 IVMLFGLILTYIVYTKLER 422
Cdd:COG2271 345 ALALLAALLALLLLRETRK 363
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
13-382 |
1.95e-54 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 186.30 E-value: 1.95e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 13 FKLIPALVILYLVAYIDRAAVGFAHLH-MGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGL 91
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 92 ITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMDGIANLH 171
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 172 GWQWLFVAVGLPAVLLALPTFLWLPDNIDKVKWLSIEQKQWLKnELVKDEAEYDQTRHANP---LHALKDKRVLLLALYY 248
Cdd:cd17327 164 GWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAV-ERLRANQTGKGDQKFKWkqiKEAFKDPRTWLLFLFF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 249 LPVTLSIYGLNLWLPTIIKQfGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGHLSFLY--ALGACAMfLSAWL 326
Cdd:cd17327 243 FCSQITNNGISNFLPLILKS-LGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACvlALVGSII-LLAAP 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 515955498 327 NSPVMQLAALaVVAFCLFSSTAVFWTLPGRFLTGASA-AAGIALINSVGNLGGYVGP 382
Cdd:cd17327 321 NPPGAYFAAY-ILGGGSYAGFPILLSWISSNCAGYTKrATVLAIMLIFYNVGNIVAP 376
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-424 |
4.29e-54 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 184.70 E-value: 4.29e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 16 IPALVILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMA 95
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 96 MALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMdgianlHGWQW 175
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA------FGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 176 LFVAVGLPAVLLALPTFLWLPDnidkvkwlsieqkqwlkneLVKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSI 255
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRD-------------------PPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 256 YGLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGHLSFLYALGACAMFLSAWLNSPVMQLAA 335
Cdd:COG2223 222 IGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 336 LAVVAFCL-FSSTAVFWTLPGRFLTgASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLILTY 414
Cdd:COG2223 302 FLLLGLALgGGNGAVFALVPDIFPT-KNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTL 380
|
410
....*....|
gi 515955498 415 IVYTKLERQK 424
Cdd:COG2223 381 LLYRRPRRAA 390
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-414 |
1.02e-32 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 127.16 E-value: 1.02e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 19 LVILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMAL 98
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 99 IQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMDGIanlhGWQWLFV 178
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----GWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 179 AVGLPAVLLALPTFLWLPDnidkvkwlsieqkqWLKNELVKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGL 258
Cdd:cd06174 157 IAAALALLAAILLLLVVPD--------------PPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 259 NLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGHLSFLYALGACAMFLSAWLNSPVMQLAALAV 338
Cdd:cd06174 223 STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515955498 339 VAFCLFSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLILTY 414
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-378 |
1.00e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 123.93 E-value: 1.00e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 14 KLIPALVILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLIT 93
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 94 MAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLlgmdgiANLHGW 173
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL------ADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 174 QWLFVAVGLPAVLLALPTFLWLPDnidkvkwlsieqkqwlknelvkDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTL 253
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPE----------------------SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 254 SIYGLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLnDRYGHLSFLYALGACAMFLSAWLNSPVMQL 333
Cdd:COG2814 222 GFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-GRRRLLLIGLLLLALGLLLLALAGSLWLLL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 515955498 334 AALAVVAFCLFSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGG 378
Cdd:COG2814 301 LALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-382 |
1.36e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 123.30 E-value: 1.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 19 LVILYLVAYIDRAAVGFA-HLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMA 97
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 98 LIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLlgmdgiANLHGWQWLF 177
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL------ASLFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 178 VAVGLPAVLLALPTFLWLPDnidkvkwlsieqkqwlKNELVKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYG 257
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPP----------------PESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 258 LNLWLPTIIKQFGGGTdIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDR--YGHLSFLYALGACAMFLSAWLNSPVMQLAA 335
Cdd:pfam07690 219 LLTYLPLYQEVLGLSA-LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrLLLALLLLILAALGLLLLSLTLSSLWLLLA 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 515955498 336 LAVVAFCLFSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGP 382
Cdd:pfam07690 298 LLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
40-416 |
5.09e-27 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 111.50 E-value: 5.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 40 MGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKwftriLLTWGLITMA-----MALIQGPKSFYLLRFLLGV 114
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLER-----TLLLALLLLAaglllRSLAPSVALLLAGTALIGA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 115 AEAGFFPGVLYLITQWYPvRHRGKIMGMFVLsqpiAMMIAGPLAGLLLGMdgIANLHGWQWLFVAVGLPAVLLALPTFLW 194
Cdd:COG2807 119 GIAVGNVLLPGLIKRWFP-DRVGLMTGLYTA----AMGLGAALAAGLTVP--LAAALGWRGALAVWALLALLALLLWLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 195 LPDNidkvkwlsieqkqwlknelvkDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTD 274
Cdd:COG2807 192 LRRR---------------------PAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 275 iQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGHLSFLYALGACAmFLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLP 354
Cdd:COG2807 251 -TAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAG-LLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLI 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515955498 355 G-RFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLILTYIV 416
Cdd:COG2807 329 GlRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
21-388 |
1.40e-24 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 104.75 E-value: 1.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 21 ILYLVAYIDRAAVGFAHLHMGADVGIGDAAYG--LGAGLF--FIGYFLFevpsNLLLDKFGARKWFTRILLTWGLITMAM 96
Cdd:TIGR00895 24 LIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGflFSAGLIgmAFGALFF----GPLADRIGRRRVLLWSILLFSVFTLLC 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 97 ALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLgmdgiaNLHGWQWL 176
Cdd:TIGR00895 100 ALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLI------PVFGWRSL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 177 FVAVGLPAVLLALPTFLWLPDNIDKVKWLSIEQKQWLKNELVKD----------EAEYDQTRHANPLHALKD----KRVL 242
Cdd:TIGR00895 174 FYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQmqaeaqsalpEQKSTQGTKRSVFKALFQgktaRITV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 243 LLALYYLPVTLSIYGLNLWLPTIIKQfGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGHLSFLYAlGACAMFL 322
Cdd:TIGR00895 254 LLWLLYFMLLVGVYFLTNWLPKLMVE-LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLG-AVFAVLV 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515955498 323 SAWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLL 388
Cdd:TIGR00895 332 GSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
42-417 |
1.77e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 103.81 E-value: 1.77e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 42 ADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFP 121
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 122 GVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLlgmdgiANLHGWQWLFVAVGLPAVLLALPTFLWLPDnidk 201
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLL------ADALGYRAPFLVCAALALLALVLALLLLPE---- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 202 vkwlsieqkqwlKNELVKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGFLS 281
Cdd:cd17325 174 ------------PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 282 SIPYVFGIIGLLIIPrstdRLNDRYGHLSFLYA---LGACAMFLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGRFL 358
Cdd:cd17325 242 GAQGLASALSQPPAG----KLSDRIGRKPLILIgllLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 515955498 359 TGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGnMAAGLYFLSIVMLFGLILTYIVY 417
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
21-393 |
5.63e-24 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 102.45 E-value: 5.63e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 21 ILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQ 100
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 101 GPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLllgmdGIANLHGWQWLFVAV 180
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLF-----GIAELYSWHWVFIVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 181 GLPAVLLALPTFLWLPDNIDKVKWLSIEQkqwLKNELVKDEAEYD----QTRHANPLHALKDKRVLLLALYYLPVTLSIY 256
Cdd:TIGR00881 157 GIIAIIVSLICFLLLRDSPQSCGLPPAEE---MPNEEPDGDAEKKeeelTKKQIFLQYVLLNKVLWYISLGYVFVYVVRT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 257 GLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGH-LSFLYALGACAMFLSAWLN---SPVMQ 332
Cdd:TIGR00881 234 GILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGpLAVFFMALIIVSLLVYWLNpaaNPLMD 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515955498 333 LAALAVVAFCLFSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTG 393
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
28-412 |
7.39e-19 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 87.26 E-value: 7.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 28 IDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYL 107
Cdd:cd17365 13 FDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 108 LRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLgmdgiaNLHGWQWLFVAVGLPAVLL 187
Cdd:cd17365 93 LRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALI------PAFGWRSVFLLGGVPPLIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 188 ALPTFLwlpdnidkvkwlsieqkqwlknelvkdeaeydqtrhanplhalkdkrVLLLALYYLPVTLSIYGLNLWLPTIIK 267
Cdd:cd17365 167 LPLLRG-----------------------------------------------TLLLWVTFFMGLLLVYLLNSWLPKLMV 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 268 QfGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGHLSFLYALGACAMFLSAWLNSPVMQLAALAVVAFCLFSST 347
Cdd:cd17365 200 E-AGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQ 278
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515955498 348 AVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLkeytgnMAAGLYFLSIVMLFGLIL 412
Cdd:cd17365 279 VGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLL------LAAGLGPESVFLALAIPA 337
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
53-413 |
8.52e-19 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 87.27 E-value: 8.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 53 LGAGLFFIGYFLFEVPSNLLL----DKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLIT 128
Cdd:cd17316 36 LQTGLLFAAGFLGRPIGALLFgylgDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 129 QWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMDGIAnlHGWQWLFVAVGLPAVLLalptfLWLPdnidkvkwlsie 208
Cdd:cd17316 116 EFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGD--WGWRILFLIGALPALLA-----LLLR------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 209 qkqwlknelvkdeaeydqtrhanplhalkdKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFG 288
Cdd:cd17316 177 ------------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 289 IIGLLIIPRSTDRLNDRYGHLSFLYALGACAM-FLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGRFLTGASAAAGI 367
Cdd:cd17316 227 LVGALIAGLLSDRIGRKKTLVIGLILSGILALpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGV 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 515955498 368 ALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLILT 413
Cdd:cd17316 307 GLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
39-423 |
1.25e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 84.14 E-value: 1.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 39 HMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAG 118
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 119 FFPGVLYLITQWYPvRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMDGIAnlhGWQWLFVAVGLPAVLLALPTFLW-LPD 197
Cdd:COG0738 113 LDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL---SWHLPYLILAVLLLLLALLFLRSkLPE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 198 nidkvkwlsieqkqwlknelVKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQI 277
Cdd:COG0738 189 --------------------IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 278 GFLSSIPYVFGIIGLLIIPRSTDRLNDRygHLSFLYALGACAMFLSAWLnSPVMQLAALAVVAFCLFSST--AVFWTLPG 355
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPV--RLLRLSALLAAVGLLLALL-APGPWLALIGLALVGLGLSLmfPTIFSLAL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515955498 356 RFLtGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGnMAAGLYFLSIVMLFGLILTYIVYTKLERQ 423
Cdd:COG0738 326 DGL-GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-413 |
1.56e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 83.75 E-value: 1.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 40 MGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGF 119
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 120 FPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLllgmdgIANLHGWQWLFVAVGLPAVLLALPTFLWLPDni 199
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGL------LGQLLGWRAAFLAIAVLALLAALLLWRLLPS-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 200 dkvkwlsieqkqwlknelVKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGF 279
Cdd:cd17324 177 ------------------LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 280 LSSIPYVFGIIGLLIIPRSTDRLNdRYGHLSFLYALGACAMFLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGRFLT 359
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRGG-RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 515955498 360 GASAAAGiALINSVGNLGGYVGPFGIGLLKEYTGnMAAGLYFLSIVMLFGLILT 413
Cdd:cd17324 318 EARGLAS-SLYLAAYNLGGALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLA 369
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
23-412 |
1.28e-14 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 75.00 E-value: 1.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 23 YLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGP 102
Cdd:cd17312 12 YAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 103 KSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGlllgmdGIANLHGWQWLFVAVGL 182
Cdd:cd17312 92 WFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAA------SLASYYGWRAAFLVPGI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 183 PAVLLALPTFLWLPDnidkvkwlsieqkqwlknelvkdeaeydqtrhanplhalKDKRVLLLALYYLPVTLSIYGLNLWL 262
Cdd:cd17312 166 VGLVVAIILFFFLRD---------------------------------------SPPYVWVLSLAYAFVYIVRYACLDWG 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 263 PTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRL-NDRYGHLSFLYALGACAMFLSAWL--NSPVMQLAALAVV 339
Cdd:cd17312 207 PLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAVIYMLLMTLSLALFWFfpHNKLLSIVLLFLI 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515955498 340 AFCLFSSTAVFWTLPGRFLTGASAA-AGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLIL 412
Cdd:cd17312 287 GFFVGGPINLIGGAAAQDIGRKEAAgTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLL 360
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
60-378 |
3.70e-14 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 73.49 E-value: 3.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 60 IGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKS-FYLLRFLLGVAEAGFFPGvLYLITQWYPVRHRGK 138
Cdd:TIGR00886 48 LAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYSvLLLIRLFIGIAGGSFASC-MPWISFFFPKKIQGT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 139 IMGMFV----LSQPIAMMIAGPLAGLLLGMDGIANLHGWQWLFVAVglPAVLLALPTFLWLPDNIDKVKWLSIEQKQWLK 214
Cdd:TIGR00886 127 ALGLAAgwgnMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIV--PAGILLLPALLIFFVGADTPPGKPATGKLSFK 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 215 nelvkdeaeydqtrhaNPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGFLSSIpyvFGIIGLLI 294
Cdd:TIGR00886 205 ----------------EALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASL---GGFLGSLA 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 295 IPrSTDRLNDRYGH---LSFLYALGACAMFLSAWLNSPVMQLAALAVVAFCLFSST-----AVFWTLPGRFLTGASAAAG 366
Cdd:TIGR00886 266 RP-AGGAISDRLGGarkLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFFAgagngSTFALVPHIFRRATGAVSG 344
|
330
....*....|..
gi 515955498 367 iaLINSVGNLGG 378
Cdd:TIGR00886 345 --LIGAIGNLGG 354
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
19-413 |
4.52e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 73.43 E-value: 4.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 19 LVILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMAL 98
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 99 IQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAmmiaGPLAGLLLgmDGIANLHGWQWLFV 178
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLG----GALAAALL--PPLALHYGWRAAFV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 179 AVGLPAVLLALPTFLWLPDnidkvkwlsieqkqwlkNELVKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGL 258
Cdd:cd17475 155 VAGLVSILAAVLFWLFYRE-----------------PPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFAL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 259 NLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLND--RYGHLSFLYALGAcAMFLSAWLNSPVMQLAAL 336
Cdd:cd17475 218 LTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrRRPVLVITAAIAA-AALLVLSLLSPGTPLWLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 337 AVVaFCLFSSTAVFWTLPGRFLTGASAAAG-----IALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLI 411
Cdd:cd17475 297 VLL-LILLGLFAIGWNGLYLTLVAESAGPEqagtaLGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
..
gi 515955498 412 LT 413
Cdd:cd17475 376 LL 377
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
40-416 |
1.45e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 71.83 E-value: 1.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 40 MGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGF 119
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 120 FPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIaGPLAGLLLGMdgianlHGWQWLFVAVGLPAVLLALPTFLWLPDNI 199
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAV-GPLLGGLLAA------ISWRYPFFLLAALIPVAFLAILFLLPEPK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 200 DKVKWLSieqkqwlknelvkdeaeydQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGF 279
Cdd:cd17474 178 EKAKSSS-------------------ATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 280 LSSIPYVFGIIGLLIIPRstdRLNDRYGHLSFLY---ALGACAMFLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGR 356
Cdd:cd17474 239 LFAGWSVLLALGSLFVGR---LLKKRFGARRILViglLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTE 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 357 FLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGnMAAGLYFLSIVMLFGLILTYIV 416
Cdd:cd17474 316 LAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
20-409 |
1.69e-13 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 71.43 E-value: 1.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 20 VILYLVA----YIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMA 95
Cdd:cd17380 1 VILLFLAtcicYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 96 MALI--QGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGkimgmFVLSQPIAMMIAGPLAGLLLGmDGIANLHGW 173
Cdd:cd17380 81 TPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERS-----RAVSIVTAGSYLGTLLGGLIG-PLLLEYYGW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 174 QWLFVAVGLPAVLLALPTFLWLPdnidkvkwlsieqkqwlknelvkdeaeydqtrhanPLHAlkdkrvllLALYYLPVTL 253
Cdd:cd17380 155 PSVFYFFGLLGLLWALVWLIYLP-----------------------------------PVWA--------IIVAHFCMNW 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 254 SIYGLNLWLPTIIKQfGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRL-NDRYGHLS---FLYALG----ACAMFLSAW 325
Cdd:cd17380 192 GFYILLSWLPTYFHE-VLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLiSRGWTVTSvrkLMQSIGflgpALFLLLLSH 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 326 LNSPVMQLAALAV-VAFCLFSSTAVFWTlpgrFLTGASAAAGI--ALINSVGNLGGYVGPFGIGLLKEYTG------NMA 396
Cdd:cd17380 271 TDSFSLALLCMSVaLGLSAFSSSGVLVN----HQDIAPNYAGIvfGISNTAGTIPGIVGVYLTGYILEATGswslvfVLA 346
|
410
....*....|....*
gi 515955498 397 AGLYFLSIV--MLFG 409
Cdd:cd17380 347 AVVNLVGAVvfLLFG 361
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
64-414 |
2.44e-13 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 71.13 E-value: 2.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 64 LFEVPSNLLLDKFGARKWFTrILLTWGLI--TMAMALIQGPKSFYLLRFLLGVAEAGFFPGVlYLITQWYPVRHRGKI-- 139
Cdd:cd17341 49 LLRLPYGFLCDRFGGRRVFI-ASLLLLLIplLALALAVSSYWGLLVLGFLLGFAGANFASGQ-PWASFWFPKEKIGGAag 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 140 ----MGMF--VLSQPIAMMIAGPLAGLLLGMdgianlhGWQWLFVAVGLPAVLLALPTFLWLPDNIDKVKWLSIEQKQWL 213
Cdd:cd17341 127 giagAGNMgvAVSQLLAPLIAGAIVFDGGFV-------GWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 214 knelvkdeaeydqtrhanplHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGFLSSIpyvFGIIGLL 293
Cdd:cd17341 200 --------------------AVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAAL---FPLAGAL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 294 IIPrSTDRLNDRYG---HLSFLYAL-GACAMFLSAWLNSPVMQLAALAVVAFCLFSST-----AVFWTLPGRFLTGASAA 364
Cdd:cd17341 257 ARP-AGGWLSDRFGgrrRLWWLFIVmTIGAALLSLSLPTSGTNLVLFLALFVALGLGAgagngSVFRMVPFIFRRELGAV 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 515955498 365 AGIalINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLILTY 414
Cdd:cd17341 336 TGL--VGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVW 383
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
72-412 |
5.02e-13 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 70.02 E-value: 5.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 72 LLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAM 151
Cdd:cd17371 57 LADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGW 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 152 MIAGPLAGLLLGMDGiaNLHGWQWLFVAVGLPAVLLalptflwlpdnidkvkwlsieqkqWLKNELVKDEAEYDQTRHAN 231
Cdd:cd17371 137 LLATLLAALLFPLLP--PEIAWRVLFLLGALPALLV------------------------LFIRRFVKEPPQWQAARAAR 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 232 PLHALKDKRVLLLALYYLPVTLSI-----------YGLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTD 300
Cdd:cd17371 191 RHFADRPSLRELFSPPLLRTTLLAsllatgalggyYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLAD 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 301 RLNDRYgHLSFLYALGACAMFLSAWLN-SPVMQLAALAVVAFCLFSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGY 379
Cdd:cd17371 271 RIGRRN-NFALFALGSAISILLYFFLPlSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGA 349
|
330 340 350
....*....|....*....|....*....|...
gi 515955498 380 VGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLIL 412
Cdd:cd17371 350 LFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVL 382
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
64-416 |
7.84e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 69.52 E-value: 7.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 64 LFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQgpkSFYLL---RFLLGVAEAGFFPGVLYLITQWYPVRHRGKIM 140
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLD---SLYALlasRALLGIGVAGIMTLATALIGDYFEGEERAKML 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 141 GMFVLSQPIAMMIAGPLAGLLLGMdgianlhGWQWLFVAVGLpAVLLALPTFLWLPDNidkvkwlsieqkqwlknelvKD 220
Cdd:cd17473 127 GLQSAAMSLGGVVFLLLGGALAEI-------GWRAPFLVYLL-ALPVLILVLLFLPEP--------------------AR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 221 EAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTD 300
Cdd:cd17473 179 KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 301 RLNDRYgHLSFLYALGACAMFLSAWLNSPVMQLAALAV--VAFCLFSSTAVFWTLpgRFLTGASAAAGIALINSVGNLGG 378
Cdd:cd17473 259 RLGKRR-LLAIGFALMALGFLLLALASGLWVVLLGAILagLGFGLLLPTLNSWAM--SLVPPELRGRAMGIVTSAFFLGQ 335
|
330 340 350
....*....|....*....|....*....|....*...
gi 515955498 379 YVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLILTYIV 416
Cdd:cd17473 336 FLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-198 |
1.13e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 68.30 E-value: 1.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 14 KLIPALVILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLIT 93
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 94 MAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIaGPLAGLLLgmdgiANLHGW 173
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLAL-GPLLGGLL-----VAALGW 167
|
170 180
....*....|....*....|....*
gi 515955498 174 QWLFVaVGLPAVLLALPTFLWLPDN 198
Cdd:COG0477 168 RWIFL-INAPLGLLALVLRLRLPES 191
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
30-412 |
1.24e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.84 E-value: 1.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 30 RAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLR 109
Cdd:cd17355 19 RYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 110 FLLGVAEAGFFPGVLYL-ITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGmdgianLHGWQWLFVAVGLPAVLLA 188
Cdd:cd17355 99 GLLGGGGAGTLAAVAFAtVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE------AFGWRTALLVLALLALLVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 189 LPTFLWLPDnidkvkwlsieqKQWLKNELVKDEAEYDQTRHAnPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQ 268
Cdd:cd17355 173 VPVLLLLRR------------RPADLALRAYDDASPASPGST-LKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 269 FGGGTdIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGHLSFLYALGACAMFLSAWLNSPVMQLAALAVVAFCLFSSTA 348
Cdd:cd17355 240 RGISP-AAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVP 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515955498 349 VFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLIL 412
Cdd:cd17355 319 LTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALL 382
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
19-409 |
3.12e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 67.65 E-value: 3.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 19 LVILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGaRKWFTRI-LLTWGLITMAMA 97
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVgILIWSAATLLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 98 LIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMDGianlhGWQWLF 177
Cdd:cd17328 83 FAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-----GWRWAF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 178 VAVGLPAVLLALPTFLWLPDN----IDKVKWLSIEQKQWLknELVKDeaeydqtrhanplhALKDKRVLLLALYYLPVTL 253
Cdd:cd17328 158 RVTGVLGVLLAILLLLFVREPprgaAEGGVMAKSTATSFL--ADLKA--------------LAKNPSFILSTLGFTAVSF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 254 SIYGLNLWLPTIIK---QFGGGTDIQIGF-LSSIPYVFGIIGLLIIPRSTDRLNDRYGH---LSFLYALGACAMFLSAWL 326
Cdd:cd17328 222 VTGALAFWAPTFFLrafGVGDLSSADVGLiFGAITCIAGVLGVLLGGILADRLRRKTPRadpLVCAVGLLAAAPFLFLAL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 327 nsPVMQLAALAVVAFCLFSSTAVF--WTL----------PGRFltgASAAAGIALINSVgnLGGYVGPFGIGLLKEYTGN 394
Cdd:cd17328 302 --VLALSNLLLAWVLLFLGEFLLSlnWAPvfaillyvviPTRR---STASAIQILLSHL--LGDAGSPYLIGLISDLLRQ 374
|
410 420
....*....|....*....|....*.
gi 515955498 395 -----------MAAGLYFLSIVMLFG 409
Cdd:cd17328 375 nkdsplaeaasLQYALLLCSFVLVLG 400
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
50-416 |
5.25e-12 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 67.27 E-value: 5.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 50 AYGLGAglFFIGYflfevpsnlLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEaGFFPGVLY---- 125
Cdd:cd17345 50 AYGLSK--FVMGN---------LSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFILLFLN-GWFQGMGWppsg 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 126 -LITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMdgiANLHGWQWLFVAVGLPAVLLALPTFLWLPDNIDKVKW 204
Cdd:cd17345 118 rTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAI---FGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 205 LSIEQkqwLKNELVKDEAEYDQTRHANPL-----HALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGF 279
Cdd:cd17345 195 PPIEE---YKGDYPEEADGEEEEQELSAWeifvkYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMW 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 280 LSSIPYVFGIIGLLIIprstdrlndryGHLSFLYALGacamflsawlNSPVMQLAALAVVAFCLFsstaVFWTLPGRFLT 359
Cdd:cd17345 272 AFSLFEWAAIPGTLLA-----------GWLSDKLFKG----------RRAPTGIIFMILVIVALI----VYWLAPNVLVD 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515955498 360 GASAAAGIALI-----------------NSVGNLGGYVGPFG-IGllkeytGNMAAGLYFLSIVMLFGLILTYIV 416
Cdd:cd17345 327 LIALIALGFLIygpvmliglqalelvpkKAAGTAAGLTGLFGyLG------GSVLATALIGIIVDHFGWNGGFIV 395
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
21-412 |
5.55e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 60.80 E-value: 5.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 21 ILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKwftRILLTWGLITMAMALIQ 100
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRR---TLILGLLLISLALALIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 101 GPKSFYL---LRFLLGVAEAGFFPGVLYLITQWYPvRHRGKIMGMFVLSQPIAMMIAGPLAGLLlgmdgIANLHGWQWLF 177
Cdd:cd17333 80 ATPSIYLfvvLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSL-----LTSELSWSWAY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 178 VAVGLPAVLLALPTFLWLPDNIDKVKwlsieqkqwLKNELVKDEAEYDQTRHANPlhalkdkRVLLLALYYLPVTLSIYG 257
Cdd:cd17333 154 LIIGLIYLLLAILILLTLFPELPSAR---------NPQQSVGAFSASASRLLRNP-------SIILGALALFLYVGAETA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 258 LNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLndRYGHLSFLYALGACAMFLSAWLN-SPVMQLAAL 336
Cdd:cd17333 218 FSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI--KPHTLLVLSGSGALLGLLILLLApTLVVGLVAT 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515955498 337 AVVAFCLFSSTAVFWTLPGRFLTGASaAAGIALINSVGNLGGYVGPFGIGLLKEyTGNMAAGLYFLSIVMLFGLIL 412
Cdd:cd17333 296 ALLGLFMAALFPTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIAE-AVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
43-417 |
1.32e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.53 E-value: 1.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 43 DVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPG 122
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 123 VLYLITQWYPVRHRGKIMGMFVLSQPIAMMIaGPLAGLLLGMDGIANLHGWqwlfVAVGLPAVLLALPTFLWLPdnidkv 202
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMAL-GPALGLFLYQHLGFAVLFI----VAAVLALLALLLVFLVKDP------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 203 kwlsieqkqwlknELVKDEAEYDQTRHanpLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQfGGGTDIQIGFLss 282
Cdd:cd17489 174 -------------PPVAAEEAEAGTRA---FRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAE-RGISNAGLFFT-- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 283 ipyVFGIigLLIIPRS-TDRLNDRYGHLSFLY---ALGACAMFLSAWLNSPVMQLAALAV--VAFCLFSSTAVFWTLpgR 356
Cdd:cd17489 235 ---VYAI--ALLLSRPfSGKLSDRKGPKTVIIpglLLLALGLLLLSFAGSPWMLLLAAVLygLGFGLLFPALQALAV--D 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515955498 357 FLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGnmAAGLYFLSIVMLFGLILTYIVY 417
Cdd:cd17489 308 LVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG--YRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
42-417 |
7.99e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 57.23 E-value: 7.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 42 ADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRI-LLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFf 120
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIgLLFTVLASLIMILFPSPWGLLIARFLSGIAAATW- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 121 pgVLYLI--TQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLllgmdgIANLHGWQWLF---VAVGLPAVLLALPtflwl 195
Cdd:cd17490 103 --VSFTVlyASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGL------IAEHFGMRAPFllaALAGVLGFILSLF----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 196 pdnidkvkwlsieqkqwLKNElvKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDI 275
Cdd:cd17490 170 -----------------IKEE--RREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 276 QIGFLSSIPYVFGIIGLLIiprSTDRLNDRYGhLSFLYALGACAMFLSAWLNSPVMQLAALAVVAFCL-FSSTAVFWTLP 354
Cdd:cd17490 231 QLGLLSIIYLLPNALASLL---SGTLFYKKLG-ERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNgFGTGILFPLLM 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515955498 355 GRFLTGASA---AAGIALINSVGNLGGYVGPFGIGLLKEYTGnMAAGLYFLSIVMLFGLILTYIVY 417
Cdd:cd17490 307 SLSIEGVPAeqrSTAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
47-415 |
1.11e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.85 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 47 GDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKW-----FTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFP 121
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 122 GVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGmdgianLHGWQWLFVAVGLPAVLLALPTFLWlpdnidk 201
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVA------LLGPGGAFAINALSFLLSALLLLFI------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 202 vkwlsieqKQWLKNELVKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGFLS 281
Cdd:cd06173 179 --------RRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 282 SIPYVFGIIGLLIIPRSTDRLNDRYgHLSFLYALGACAMFLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGRFLTGA 361
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGR-LLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDE 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 515955498 362 SAAAGIALINSVGNLGGYVGPFGIGLLKEYTGnMAAGLYFLSIVMLFGLILTYI 415
Cdd:cd06173 330 LRGRVFSVYNALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
45-412 |
1.77e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 56.03 E-value: 1.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 45 GIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVL 124
Cdd:cd17477 27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 125 YLITQWYPVRHRGKIMGMFVLSQpIAMMIAGPLAGlllgmdGIANLHGWQWLFVAVGLPAVLLALPTFLWLPdnidkvkw 204
Cdd:cd17477 107 SWLNALATNENRGRVLGLYSTVL-GLGFALGPLLL------ALVGTAGALPFLIAAVLLLLALVPLLLTRRA-------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 205 lsieqkqwlknelvkdEAEYDQTRHANPLHALKDKRVLLL-ALYYLPVTLSIYGLnlwLPTIIKQFGGGTDiQIGFLSSI 283
Cdd:cd17477 172 ----------------APEIEEAESISLRRLLRIAPLALLgAFVAGFLEGAFYSL---LPLYGLRLGLSVA-QAALLLAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 284 PYVFGIIGLLIIPRSTDRLNDRYGHLSFLYALGACAMFLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGRFLTGASA 363
Cdd:cd17477 232 FVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDEL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 515955498 364 AAGIALINSVGNLGGYVGPFGIGLLKEYTGNmaAGLYFLSIVMLFGLIL 412
Cdd:cd17477 312 VAANAALLLLYGLGSVIGPLLAGALMDAFGP--HGLFLFLAAVALLFLL 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
38-195 |
2.83e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 55.27 E-value: 2.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 38 LHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEA 117
Cdd:cd17325 224 LYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLG 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515955498 118 GFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLlgmdgiANLHGWQWLFVAVGLPAVLLALPTFLWL 195
Cdd:cd17325 304 LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL------YDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
43-416 |
3.07e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 55.31 E-value: 3.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 43 DVGIGDAAYGLGAGLFFIGYFLFevPSNLLLDKFGARK--WFTRILLTWGLITMAMAlIQGPKSFYLLRFLLGVAEAGFF 120
Cdd:cd17353 34 GWSLASVALAFTLTIVFLAISAP--FAGRLVDRGGPRKaiLIGGILFGLGFILSAFA-ISLPLLFLGYGVLGGIGAGIGY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 121 PGVLYLITQWYPVRhRGKIMGMFVLSQPIAMMIAGPLAGLLLGMDGIANL---HGWQWLFVAVGLpAVLLALPTFLWLPD 197
Cdd:cd17353 111 ITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTfliLGIIFLIIIVIG-AFLIRDPPKGWVPP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 198 NIDKVKWlsieqkqwlknelvkdeAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQI 277
Cdd:cd17353 189 GVDPLAN-----------------NAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 278 GFLSSIPYVFGIIGLLIIPRSTDRLnDRYGHLSFLYALGACAMF-LSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGR 356
Cdd:cd17353 252 ALAVSILSIFNGGGRPFWGWLSDKI-GRKNTLSIAFLIQGVAMFlLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTAD 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 357 FLTGASAAAGIALINSVGNLGGYVGPFgIGLLKEYTGNMAAGLYFLSIVMLFGLILTYIV 416
Cdd:cd17353 331 FFGTKNAGTNYGLLYTAKGVGGLIGPI-IAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
40-413 |
5.12e-08 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 54.62 E-value: 5.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 40 MGADVGIGDAAYGLGAGLFFIGYFLfevpsNLLLDKFGARKWFTRILLTWGLI-----TMAMALIQGPKSFYLLRFLLGV 114
Cdd:cd06180 25 MLAELGLSYAQAGWIATANYAGYLV-----GALLASFLRRRGRARRLIRGGLLltvllLAAMALTSGFAALLALRFLAGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 115 AEAGFFPGVLYLITQWYPVRHRGkimgmfvlsQPIAMMIAGPLAGLLLGMDGIANLH----GWQWLFVAVGLPAVLLALP 190
Cdd:cd06180 100 ASAFVFVFGSNLVLHHATAAGRG---------HLIGLLFAGVGLGIALSGLLVPAGLggglSWRAGWLALALLSAVLLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 191 TFLWLPdnidkvkwlsieqkqwlknelvkdEAEYDQTRHANPLHAL-KDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQF 269
Cdd:cd06180 171 SFLLLR------------------------RGPSAPTEASAAESAPgLNRPLWRLALAYGLFGFGYIITATFLPLIARET 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 270 GGGTdIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGhLSFLYALGACAMFLSAWLNSPVMQLAALAVVAFCLFSSTAV 349
Cdd:cd06180 227 GAGS-LLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRA-LAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITAL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515955498 350 FWTLpGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLILT 413
Cdd:cd06180 305 VMAL-ARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLA 367
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
134-415 |
8.71e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.14 E-value: 8.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 134 RHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMDGIANLHGWQWLFVAVGLPAVLLALPTFLWLPDNIDKVkwlsiEQKQWL 213
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPE-----EEKVSL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 214 KNELvkdeaeydqtrhanpLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLL 293
Cdd:COG2211 218 KESL---------------KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAP 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 294 IIPRSTDRLNDRYGHL--SFLYALGACAMFLSAWlNSPVMQLAALAVVAFCLFSSTAVFWTL------PGRFLTGASAAA 365
Cdd:COG2211 283 LWPRLAKRFGKKKAFIigLLLAALGLLLLFFLGP-GNLWLLLVLAALAGIGLGAILVLPWAMladvvdYDEWKTGRRREG 361
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 515955498 366 GI-ALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLILTYI 415
Cdd:COG2211 362 LYfGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLL 412
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
51-415 |
1.53e-07 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 53.43 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 51 YGLGAGLFFIGYFLFEVPSNLLLDKFGaRKWftrILLTWGLITMAMALIQG----PKSFYLL---RFLLGVAEAGFFPGV 123
Cdd:pfam00083 48 SGLIVSIFSVGCFIGSLFAGKLGDRFG-RKK---SLLIANVLFVIGAVLQGaakgKWSVYQLivgRVLVGIGVGGASVLA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 124 LYLITQWYPVRHRGKIMGMFVLSQPIAMMIAgplAGLLLGMDGIANLHGWQWLFVAVGLPAVLLAL--------PTFLWL 195
Cdd:pfam00083 124 PMYISEIAPKKLRGALGSLYQLAITFGILLA---YIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIgllflpesPRWLVE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 196 PDNIDKVK------WLSIEQKQWLKNELVKDEAEYDQTRH-ANPLHALKDKRVLLLALYYLPVTLSIYGLN---LWLPTI 265
Cdd:pfam00083 201 KGRLEEARevlaklRGVPDVDRELDEIKDSLEAGQEAEKAsWKELFSTKTRRQRLLIGVMLQIFQQLTGINaifYYSTTI 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 266 IKQFGGGTDIQIGFLSSIPY-VFGIIGLLIIprstDRLNDRYGHLSFLYALGACAMFLSA---WLNSPVMQLAALAVVAF 341
Cdd:pfam00083 281 FENLGLSDSFLVTIIVGVVNfVFTFIAIFLV----DRFGRRPLLLLGAAGMAICFVILGIvalLGVSKSDWAGIVAIVFI 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 342 CLF------SSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSiVMLFGLILTYI 415
Cdd:pfam00083 357 ALFiaffamGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAG-LLVLFIIFVFF 435
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
19-194 |
3.46e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.79 E-value: 3.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 19 LVILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMAL 98
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 99 IQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLgmdgiaNLHGWQWLF- 177
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLL------ELFGWRWIFl 154
|
170
....*....|....*....
gi 515955498 178 --VAVGLPAVLLAlPTFLW 194
Cdd:cd17321 155 inVPIGLVALLLA-RTFSG 172
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
35-417 |
4.08e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.84 E-value: 4.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 35 FAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGV 114
Cdd:cd17329 21 FMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 115 AEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGmdgianlHGWQWLFVAVGLPAVLLALPTFLW 194
Cdd:cd17329 101 GGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-------YSFRLLFLAAAVLFLLAALVLLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 195 LPDNI-DKVKWLSIEQKQWLKNelvkdeaeydqtrhanplhALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGT 273
Cdd:cd17329 174 LPETRpKRRAAEKTEILRGYKI-------------------VLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 274 DIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGhLSFLYALGACAMFLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTL 353
Cdd:cd17329 235 ESLLGLLLALNALLIVLLQFPVARLVERFRLRKI-LMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515955498 354 PGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAgLYFLSIVMLFGLILTYIVY 417
Cdd:cd17329 314 VAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLP-WLILAALGLIAAALLLGLQ 376
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
64-411 |
6.31e-07 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 51.04 E-value: 6.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 64 LFEVPSNLLLDKFGARK--WFTRILLTWGLItmaMALIQGPKSFYLLRFLLGVAEAgfFPGVLY--LITQWYPvRHRGKI 139
Cdd:cd17339 49 VFSPLAPRLARRFGLERtlLLALLLLAAGIL---LRSLGGIALLFLGTALAGAGIA--VGNVLLpsLIKRDFP-RRVGLM 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 140 MGMFVLS----QPIAMMIAGPLAGLLLGmdgianlhGWQWlfvAVGLPAVLLALPTFLWLPdnidkvkwlsieqkQWLKN 215
Cdd:cd17339 123 TGLYTTSmnlgAALASGLSVPLAQALGG--------GWRG---ALAIWALPALLALLIWLP--------------QLRRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 216 ElvkdeAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTdIQIGFLSSIPYVFGIIGLLII 295
Cdd:cd17339 178 K-----RAAAAAAPLTKISVWRSPLAWQVTLFMGLQSLLFYTLMAWLPTILIDAGLSA-ATAGWLLSLFQLVGIPASLLV 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 296 PRSTDRLNDRYGHLSFLYALGACAM--FLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLpgRFLTGASAAAGIALINSV 373
Cdd:cd17339 252 PILATRLKNQRPIVVLLAVLFIIGVlgLLFAPTALALLWAVLLGLGGGAAFSLALTLISL--RSSDPAEAAALSGMAQSV 329
|
330 340 350
....*....|....*....|....*....|....*...
gi 515955498 374 GNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLI 411
Cdd:cd17339 330 GYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVLQLV 367
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
58-196 |
1.23e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 50.31 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 58 FFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIqGPKSFYLL---RFLLGVAEAGFFPGVLYLITQWYPVR 134
Cdd:cd17318 65 FFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLA-ARGGYGALivlRILQGLAQGVTFPAMHALWAKWAPPL 143
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515955498 135 HRGKiMGMFVLS-QPIAMMIAGPLAGLllgmdgIANLHGWQWLFVAVGLPAVLLALPTFLWLP 196
Cdd:cd17318 144 ERSR-LTSIAYSgSQFGTVIAMPLSGF------LCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
56-197 |
2.05e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.87 E-value: 2.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 56 GLFFIGY----FLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWY 131
Cdd:TIGR00880 1 GLLLAGYalgqLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515955498 132 PVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMDGianlhgWQWLFVAVGLPAVLLALPTFLWLPD 197
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLG------WRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
44-196 |
3.07e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 3.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 44 VGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQG--PKSFYLLRFLLGVAEAGFFP 121
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnLWLLLVLAALAGIGLGAILV 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 122 GVLYLIT-------QWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLGMDGI--------ANLHGWQWLFVAVGLPAVL 186
Cdd:COG2211 339 LPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYvagaaqspSALTGIRLLFFLLPAVLLL 418
|
170
....*....|
gi 515955498 187 LALPTFLWLP 196
Cdd:COG2211 419 LAALLLLFYP 428
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
13-383 |
3.35e-06 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 48.94 E-value: 3.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 13 FKLIPALVILYLVAYIDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLI 92
Cdd:cd17488 2 IHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 93 TMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPiammIAGPLAGLLLGMdgIANLHG 172
Cdd:cd17488 82 NILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHN----IGGALIPILTGF--AALTYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 173 WQWLFVAVGLPAVLLALptflwlpdnidkvkwlsieqkqWLKNELvKDEAEYdqtrhanplhalkdkrVLLLALYYLPVT 252
Cdd:cd17488 156 WRAGMYVPGIIAILMGI----------------------VLCWRL-RDRPPY----------------IWLLAFCYVLVY 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 253 LSIYGLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRL-NDRYGHLSFLYALGACAMFLSAWLnSPVM 331
Cdd:cd17488 197 VVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLfKGNRGPMNLIFALGLLVSVGALWL-VPVH 275
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 515955498 332 QLAALAVVAFCLfsstavfwtlpGRFLTG-----ASAAAGIALINSVGNLGGYVGPF 383
Cdd:cd17488 276 SYWLLATCFFTI-----------GFFVFGpqmliGMAAAECSHKDAAGSATGFVGLF 321
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
72-381 |
3.39e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.73 E-value: 3.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 72 LLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAM 151
Cdd:cd17503 54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 152 MIAGPLAGLLLgmdgiaNLHGWQWLF-VAVGLPAVLLALPTFLwlpdnidkvkwlsieqkqwlknelvkdeaeydqtrha 230
Cdd:cd17503 134 AIGPTLGGWLT------DNLSWRWIFyINLPIGILALLLAPLL------------------------------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 231 nPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGHLS 310
Cdd:cd17503 171 -DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLA 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515955498 311 -FLYALGACAMFLSAWLNSPVMQLAALAVV---AFCLFSSTAVFWTLPGrfLTGASAAAGIALINSVGNLGGYVG 381
Cdd:cd17503 250 gLLLLALGTLLLAFLTPDTSLWLIILPLFIrglGMGLVFMPLNTLALNS--LPPEQIGDATALFNTIRQLGGSIG 322
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
241-416 |
7.03e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 7.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 241 VLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDiQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGhLSFLYALGACAM 320
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPA-QAGLVVTAYLLGAALGAPLAGRLADRFGRRRV-LLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 321 FLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGnMAAGLY 400
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFL 168
|
170
....*....|....*.
gi 515955498 401 FLSIVMLFGLILTYIV 416
Cdd:COG2814 169 VNAVLALLALLLLLRL 184
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
9-189 |
7.97e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 7.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 9 RTVTFKLIPALVILYLVAYIDRAAVGFAHLHmGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARkwftRILLT 88
Cdd:cd17477 184 RRLLRIAPLALLGAFVAGFLEGAFYSLLPLY-GLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRR----RVLLG 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 89 WGLITMAMAL-----IQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLLg 163
Cdd:cd17477 259 CALLGALAALllplvPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALM- 337
|
170 180
....*....|....*....|....*.
gi 515955498 164 mdgiaNLHGWQWLFVAVGLPAVLLAL 189
Cdd:cd17477 338 -----DAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
57-196 |
9.51e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 47.19 E-value: 9.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 57 LFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHR 136
Cdd:cd17317 33 IFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYR 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 137 GKIMGMFVLSQPIAMMIAGPLAGLllgmdgianLHGWQWLFVAVGLPAVLLaLPTFLWLP 196
Cdd:cd17317 113 SFVGILFGLFWALGYMLLALLAYL---------IRDWRWLQLAISLPGLLF-LLLLWWLP 162
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
57-350 |
1.46e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 47.32 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 57 LFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHR 136
Cdd:TIGR00898 135 CFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQR 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 137 GKimgmfvlsqpIAMMIAGPLAGLLLGMDGIANL-HGWQWLFVAVGLPAVLLALPTFlWLPDNIdkvKWLSIEQKQ---- 211
Cdd:TIGR00898 215 AI----------VGTLIQVFFSLGLVLLPLVAYFiPDWRWLQLAVSLPTFLFFLLSW-FVPESP---RWLISQGRIeeal 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 212 -----------------WLKNELVKDEAEYDQTRHANPLHALKDKRVLLLALYYL--PVTLSIYGLNLWLPTIikqfgGG 272
Cdd:TIGR00898 281 kilqriakingkklpaeVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLwfTTAFSYYGLVLDLGNL-----GG 355
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515955498 273 TDIQIGFLSSIPYVFG-IIGLLIIprstDRLNDRYGHLSFLYALGACAMFLSAWLNSPVMQLAALAVVAFclFSSTAVF 350
Cdd:TIGR00898 356 NIYLDLFISGLVELPAkLITLLLI----DRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGK--FGITSAF 428
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
58-417 |
1.61e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 47.05 E-value: 1.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 58 FFIGYFLFEVPSNLLLDKFGArKWFTRILLTWGLITMAMALIQGPKSFYLL---RFLLGVAEAGFFPGVLYLITQWYPVR 134
Cdd:TIGR00894 85 HFYGQIIIQIPVGYLAGKYVF-KWSIGIGMFLSSVISIVIPWAAGGGIALVvfcRVIQGLAQGSVSPATHKIIVKWAPPK 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 135 HRGKIMGMFVLSQPIAMMIAGPLAGLLLGMDGianlhGWQWLFVAVGLPAVLLALPTFLWLPDNIDKVKWLSIEQKQWLK 214
Cdd:TIGR00894 164 ERSRLLGMSTSGFQLGTFIFLPISGWLCESWG-----GWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYIN 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 215 NELVkdeaeydQTRHANPLHALKDKRVLLLALYylPVTLSIYGLN-------LWLPTIIKQFGGGTDIQIGFLSSIPYVF 287
Cdd:TIGR00894 239 SSLQ-------GQKGSTRQSLPIKAIPKSLPVW--AIWFAIFGHFwlytilpTYLPTFISWVLRVSGKENGLLSSLPYLF 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 288 GIIGLLIIPRSTDRLNDRyGHLSF-----------LYALGACAMFLSAwlnspVMQLAALAVVAFCLFSSTAVFwTLPGr 356
Cdd:TIGR00894 310 AWLCSIFAGYLADFLKSS-KTLSLtaarkifngigGLGPGIFAYALPY-----LSAAFYLTIIILTLANAVSSG-PLAG- 381
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515955498 357 FLTGASAAAGIAL--INSVGNLGGYVGPFGIGLLkeyTGNM----AAGLYFLSIVMLFGLILTYIVY 417
Cdd:TIGR00894 382 VLINSLDLAPRFLgfIKGITGLPGFIGGLIASTL---AGNIlsqdSKNVWLIVFLIMAFVNILCVIF 445
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
233-416 |
5.14e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 5.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 233 LHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGgTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGHLSFL 312
Cdd:cd17352 177 LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGI-DESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIF 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 313 YALGACAMFLSAWLNspvMQLAALAVVAFCLFSSTAVFWTLPGRFLTGA------SAAAGIALInsVGNLGGYVGPFGIG 386
Cdd:cd17352 256 TLLILGLSLLAFPLA---TTYVGLIVFSVLFGFCSGSYSSLTPVILADLvgleklSNAYGLVLL--FQGLAALVGPPIAG 330
|
170 180 190
....*....|....*....|....*....|
gi 515955498 387 LLKEYTGNMAAGLYFLSIVMLFGLILTYIV 416
Cdd:cd17352 331 LLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
13-189 |
6.14e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 6.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 13 FKLIPALVILYLVAYIDRAavgFAHLHMgADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLI 92
Cdd:cd17370 202 FWLYLLAVALFALGNFSFA---FLILRA-QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 93 TMAMALIQGPKSFYLLRFLLGV---AEAGFFPGVLYLITqwyPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLlgmdgiAN 169
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLymgAQESIERAAVADLV---PAELRGTAYGLFNTVVGIGWLLASLIAGYL------WD 348
|
170 180
....*....|....*....|
gi 515955498 170 LHGWQWLFVAVGLPAVLLAL 189
Cdd:cd17370 349 LISPSAAFLFSAVLALIALL 368
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
45-193 |
6.60e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.91 E-value: 6.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 45 GIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVL 124
Cdd:cd06173 240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515955498 125 YLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLAGLLlgmdgiANLHGWQWLFVAVGLPAVLLALPTFL 193
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLL------ADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
57-392 |
6.87e-05 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 44.59 E-value: 6.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 57 LFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHR 136
Cdd:cd17374 43 IFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 137 GKIMGMFVLSQPIAMMIagpLAGLLLGmdgianLHGWQWLFVAVGLPAVLLALpTFLWLPdnidkvkwlsieqkqwlkne 216
Cdd:cd17374 123 ALAITLTSCFFSIGQML---LAGLAYA------IRDWRLLQLVVSVPFFLFFL-YSWWLP-------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 217 lvkdeaeydqtrhanplhalkdKRVLLLALYYLPVTLSIYGLNLWLPTIikqfggGTDIqigFLSSIpyVFGIIGLL--- 293
Cdd:cd17374 173 ----------------------KRTLILSFVWFANSFSYYGLSLDLQHL------GLNV---FLLQF--LFGAVEVParc 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 294 IIPRSTDRLNDRYGHLSFLYALGAC---AMFLSAWLNSPVMQLAALAVvaFCLFSSTAVFWTLPGRFLTGASAAAGIALI 370
Cdd:cd17374 220 LALFLLNHMGRRISQAVLLLLAGLCilaNIFVPQEMQTLRTVLAVLGK--GSSAAAFTISYVYTAELFPTVLRQTGMGLN 297
|
330 340
....*....|....*....|..
gi 515955498 371 NSVGNLGGYVGPFgIGLLKEYT 392
Cdd:cd17374 298 SMFARIGGILAPL-IMLLGVYS 318
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
40-413 |
6.91e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.87 E-value: 6.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 40 MGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGF 119
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 120 FPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAgPLAGLLlgmdgIANLHGWQWLFVAVGLPAVLLALPTFLWLPDNI 199
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALA-PLLGGL-----LLLFFGWRAIFVFLALLGLLLLLLVLLFLPETL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 200 DkvkwlsieqkqwlknelVKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGF 279
Cdd:cd17320 179 P-----------------EEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 280 LSSIPYVFGIIGLLIIPRSTDRLNDR--YGHLSFLYALGACAMFLSAWLNSpvMQLAALAVVAFCLFSSTAV-FWTLPGR 356
Cdd:cd17320 242 LFALNAIALILGSLLNGRLVRRFGPRrlLRLGLLLLLAAALVLLLAALLGG--LSLWPLVAPLFLIFFGFGLiFPNATSL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 357 FLTGASAAAGIA--LINSVGNLGGYVGPFGIGLLKE-YTGNMAAGLYFLSIVMLFGLILT 413
Cdd:cd17320 320 ALEPFPHVAGTAsaLLGFLQFLIGALAGALVGLLPNgTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
33-269 |
8.13e-05 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 44.90 E-value: 8.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 33 VGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLL 112
Cdd:cd17440 18 VGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 113 GVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLA-------GLLLGMDGIANLHGWQWLFVAVGLPAV 185
Cdd:cd17440 98 GFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAwaiiphyGWSFSMGSAYQFHSWRVFVIVCALPCV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 186 LlALPTFLWLPDNIDKVKWLSIEQKQWLKNELVKDE--AEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLP 263
Cdd:cd17440 178 S-SVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTnmRARGQPEKVFTVNRIKKDNTIKLTIVWLTLSFGYYGLSVWFP 256
|
....*.
gi 515955498 264 TIIKQF 269
Cdd:cd17440 257 DVIKHL 262
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
39-412 |
2.05e-04 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 43.13 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 39 HMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGAR-KWFTRI-LLTWGLITMAMALIQGPKSFYLLRFLLGVAE 116
Cdd:pfam06779 18 VMIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRlRPALLAgLLATVLLLLAMAATSSFWAVLLIRFLAGVAS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 117 AGffpgVLYLITQWYpVRHRGKIMGMFVlsqpIAMMIAGPLAGLLLG--MDGIANLHGWQ--WLFVAVGLPAVLLALPTF 192
Cdd:pfam06779 98 AA----VMIFGSSLI-LGHATAARRAFV----GALLFAGVGIGIALSglLVPLGLQLGLGgsSLWYGAGVLSAVLTLAVF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 193 LWLPDnidkvkwlsieqkqwlknelVKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLnlWLPTIIKQFGGG 272
Cdd:pfam06779 169 PLLPR--------------------RAPRHASAPAPAAKPLQRSLPLWILTLAYGLAGFGYIITAT--FLPAMARDGFGG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 273 TDIQIGFLSsipyvfgIIGLLIIPRS--TDRLNDRYGHLSFL---YALGACAMFLSAWLNSPVmqLAALAVVAFCLFSST 347
Cdd:pfam06779 227 PAAAALFWS-------LFGLAAALGVlvWLRAAKRWGTRPALtaaLLIQALGVLLSLLSPSPA--GLAVSSLLFGGTFMA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515955498 348 AVFWTLP-GRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAGLYFLSIVMLFGLIL 412
Cdd:pfam06779 298 ITSLVMQlARELAPPAPRRLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALI 363
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
42-412 |
2.62e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 43.02 E-value: 2.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 42 ADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFfp 121
Cdd:cd17393 27 DRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGAL-- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 122 GVLYLITQWYPVRHRGK-IMGMFVlsqpiAMMIAGPLAGLLLGMDGIANLHGWQWLFVAVGLPAVLLALPTFLWLPDnid 200
Cdd:cd17393 105 DVAMNAQGVAVERAYGRpIMSSLH-----AMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLP--- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 201 kvkwlsieqkqwlkneLVKDEAEYDQTRHANPLHALKDKRVLLLALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQigfl 280
Cdd:cd17393 177 ----------------GTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAAL---- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 281 SSIPYVFGIIGLLIIPRSTDRLNDRYGHLSFLYALGACA---MFLSAWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGRf 357
Cdd:cd17393 237 AALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAalgLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGA- 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 515955498 358 LTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGNMAAglyFLSIVMLFGLIL 412
Cdd:cd17393 316 LPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTA---FLVVALLALLVA 367
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
55-196 |
5.77e-04 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 41.64 E-value: 5.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 55 AGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVR 134
Cdd:cd17447 41 ATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIE 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515955498 135 HRGKIMGMFVLSQPIAMMIAGPLAGLllgmdgianLHGWQWLFVAVGLPaVLLALPTFLWLP 196
Cdd:cd17447 121 HRTVAGVLISLFWTVGNMLLALVAYL---------IRDWRWLILAVTLP-CAPGIITWWWVP 172
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
48-414 |
8.84e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 41.48 E-value: 8.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 48 DAAYGLGAGLFFIGYFLFEVPSNLLLDKFGaRKWFTRI----LLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGV 123
Cdd:cd17357 48 DLLWSLIVSIFFIGGAIGSFISAFLANRFG-RKNGLLIsnalLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFV 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 124 LYLITQWYPVRHRGkIMGMFvLSQPIAMMIagpLAGLLLGMDGI-ANLHGWQWLFVAVGLPAVLLALPTFlWLPDNidkV 202
Cdd:cd17357 127 PMYLQEISPSELRG-ALGSL-TQIGVTLGI---LLGQVFGLPSVlGTETLWPYLLFFPGIPALLQLAALP-FFPES---P 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 203 KWLSIEQK---------QWLKNEL-----VKDEAEYDQTRHANP-----LHALKDK-----RVLLLALYYLPVTLSIYGL 258
Cdd:cd17357 198 KFLLISKGdeeeaekslKFLRGIEddvdqELEEIKKESEQMGDQkqvslMQLLRDPslrlpLLLVLVVSASQQFSGINAI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 259 NLWLPTIIKQFGGGTD--IQIGFLSSIPYVFGII-GLLIIprstDRLNDRYGHLSFLYALGACAMFLSAWLN--SPVMQL 333
Cdd:cd17357 278 FFYSTFIFENAGFSPQlaEWANLGIGIVNVLSTIvGPFLI----EKVGRRPLLLISLSVCAVALLLMSVFLFlsEQNSWM 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 334 AALAVVAFCLFssTAVF--------WTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGnmaaGLYFL--S 403
Cdd:cd17357 354 SYGCIVAIFLF--IFFFaiglgpipWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGG----GFVFIifA 427
|
410
....*....|.
gi 515955498 404 IVMLFGLILTY 414
Cdd:cd17357 428 IPCALFLLYLY 438
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
244-416 |
1.23e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 244 LALYYLPVTLSIYGLNLWLPTIIKQFGGGTDIQIGFLSSIPYVFGIIGLLIIPRSTDRLNDRYGhLSFLYALGACAMFLS 323
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV-LLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 324 AWLNSPVMQLAALAVVAFCLFSSTAVFWTLPGRFLTGASAAAGIALINSVGNLGGYVGPFGIGLLKEYTGnMAAGLYFLS 403
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILA 158
|
170
....*....|...
gi 515955498 404 IVMLFGLILTYIV 416
Cdd:pfam07690 159 ILSLLAAVLLLLP 171
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
28-269 |
1.26e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 41.06 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 28 IDRAAVGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYL 107
Cdd:cd17438 13 VEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 108 LRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLA-------GLLLGMDGIANLHGWQWLFVAV 180
Cdd:cd17438 93 CRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAwsiiphyGWGFSMGTNYHFHSWRVFVIIC 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 181 GLP--AVLLAL------PTFLWLPDNIDKVkWLSIEQKQwLKNELVKDEAEYDQTrhanpLHALKDKRVLLLALYYLPVT 252
Cdd:cd17438 173 ALPciASIIALkfmpesPRFLLEMGKHDEA-WMILKNIH-DTNMRAKGTPEKVFT-----VSNIKRKNTLFLAVVWFTMA 245
|
250
....*....|....*..
gi 515955498 253 LSIYGLNLWLPTIIKQF 269
Cdd:cd17438 246 FSYYGLTVWFPDMIRYL 262
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
72-189 |
1.31e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.71 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 72 LLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAm 151
Cdd:cd17391 263 LGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLG- 341
|
90 100 110
....*....|....*....|....*....|....*...
gi 515955498 152 MIAGPLAGLLlgmdgIANLHGWQWLFVAVGLPAVLLAL 189
Cdd:cd17391 342 NVAGPLLGSA-----IAAHFGYRAVFVVTALLVLLNAI 374
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
33-267 |
1.39e-03 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 40.78 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 33 VGFAHLHMGADVGIGDAAYGLGAGLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLL 112
Cdd:cd17439 18 VGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 113 GVAEAGFFPGVLYLITQWYPVRHRGKIMGMFVLSQPIAMMIAGPLA-------GLLLGMDGIANLHGWQWLFVAVGLPAV 185
Cdd:cd17439 98 GVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAwaiiphyGWSFQMGSAYQFHSWRVFVLVCAFPSV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 186 LlALPTFLWLPDNIDKVKWLSIEQKQWLKNELVKD---EAEYDQTRHANPLHaLKDKRVLLLALYYLPVTLSIYGLNLWL 262
Cdd:cd17439 178 F-AIGALTTMPESPRFFLENGKHDEAWMVLKQVHDtnmRAKGHPERVFSVTH-IKRRITLMMMAVWFTMSFSYYGLTVWF 255
|
....*
gi 515955498 263 PTIIK 267
Cdd:cd17439 256 PDMIK 260
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
49-195 |
1.62e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 40.32 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 49 AAYGLGAGLFFIgyflfevPSNLLLDKFGARKWFTRILLTWGLITMAMALIQGPKSFYLLRFLLGVAEAGFFPGVLYLIT 128
Cdd:cd17476 40 ASYSLTVGTFIL-------IFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLG 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515955498 129 QWYPV-RHRGKIMGMFVLSQPIAMMIAGPLAGLllgmdgIANLHGWQWLFVAVGLPAVLLALPTFLWL 195
Cdd:cd17476 113 RTYPPgPRKNIVFSLFGATAPLGFALGGVFGGL------FAQLAWWPWIFWFLAILAAIVAVAAIFWT 174
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
56-195 |
7.05e-03 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 38.61 E-value: 7.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955498 56 GLFFIGYFLFEVPSNLLLDKFGARKWFTRILLTWGLITMAMALIQ--GPKSFYLLRFLLGVAEAGFFPGVLYLITQWYPV 133
Cdd:cd17381 72 GSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAAdlGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPP 151
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515955498 134 RHRGKIMGMFVLSQPIAMMIAGPLAGLllgmdgIANLHGWQWLFVAVGLPAVLLAlptFLWL 195
Cdd:cd17381 152 LERSRLLTISYAGAQLGTVVSLPLSGL------ICYYLDWTYVFYIFGAVGLLWF---FLWI 204
|
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