NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|515955808|ref|WP_017386391|]
View 

MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Acinetobacter]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
8-130 1.59e-23

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 89.26  E-value: 1.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955808   8 PKKVEDEPKLSYMIARVDRIISKHLTEHLKELEITLPQFTALSVLASKSNLSNAKLAERSFIKPQSANKILQDLLVNGWI 87
Cdd:COG1846    3 DEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 515955808  88 EKKPDPTHGRRILITLTDSGIDKLNKCNEVVLKVEEKMLEGID 130
Cdd:COG1846   83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLS 125
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
8-130 1.59e-23

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 89.26  E-value: 1.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955808   8 PKKVEDEPKLSYMIARVDRIISKHLTEHLKELEITLPQFTALSVLASKSNLSNAKLAERSFIKPQSANKILQDLLVNGWI 87
Cdd:COG1846    3 DEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 515955808  88 EKKPDPTHGRRILITLTDSGIDKLNKCNEVVLKVEEKMLEGID 130
Cdd:COG1846   83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLS 125
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
34-132 2.09e-17

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 72.24  E-value: 2.09e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955808    34 EHLKELEITLPQFTALSVLASKSNLSNAKLAERSFIKPQSANKILQDLLVNGWIEKKPDPTHGRRILITLTDSGIDKLNK 113
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90
                   ....*....|....*....
gi 515955808   114 CNEVVLKVEEKMLEGIDIN 132
Cdd:smart00347  81 LLEARSETLAELLAGLTAE 99
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 41-98 1.28e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 51.05  E-value: 1.28e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 515955808   41 ITLPQFTALSVLASKSNLSNAKLAERSFIKPQSANKILQDLLVNGWIEKKPDPTHGRR 98
Cdd:pfam12802   3 LTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
17-118 1.64e-08

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 50.28  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955808  17 LSYMIARVDRIISKHLTEHLKELEITLPQFTALSVLASKSNLSNAKLAERSFIKPQSANKILQDLLVNGWIEKKPDPTHG 96
Cdd:PRK11512  14 LGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDK 93

                         90       100
                 ....*....|....*....|..
gi 515955808  97 RRILITLTDSGIDKLNKCNEVV 118
Cdd:PRK11512  94 RGVLVKLTTSGAAICEQCHQLV 115
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
8-130 1.59e-23

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 89.26  E-value: 1.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955808   8 PKKVEDEPKLSYMIARVDRIISKHLTEHLKELEITLPQFTALSVLASKSNLSNAKLAERSFIKPQSANKILQDLLVNGWI 87
Cdd:COG1846    3 DEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 515955808  88 EKKPDPTHGRRILITLTDSGIDKLNKCNEVVLKVEEKMLEGID 130
Cdd:COG1846   83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLS 125
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
34-132 2.09e-17

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 72.24  E-value: 2.09e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955808    34 EHLKELEITLPQFTALSVLASKSNLSNAKLAERSFIKPQSANKILQDLLVNGWIEKKPDPTHGRRILITLTDSGIDKLNK 113
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90
                   ....*....|....*....
gi 515955808   114 CNEVVLKVEEKMLEGIDIN 132
Cdd:smart00347  81 LLEARSETLAELLAGLTAE 99
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 41-98 1.28e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 51.05  E-value: 1.28e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 515955808   41 ITLPQFTALSVLASKSNLSNAKLAERSFIKPQSANKILQDLLVNGWIEKKPDPTHGRR 98
Cdd:pfam12802   3 LTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
17-118 1.64e-08

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 50.28  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955808  17 LSYMIARVDRIISKHLTEHLKELEITLPQFTALSVLASKSNLSNAKLAERSFIKPQSANKILQDLLVNGWIEKKPDPTHG 96
Cdd:PRK11512  14 LGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDK 93

                         90       100
                 ....*....|....*....|..
gi 515955808  97 RRILITLTDSGIDKLNKCNEVV 118
Cdd:PRK11512  94 RGVLVKLTTSGAAICEQCHQLV 115
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 41-99 1.71e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 42.92  E-value: 1.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 515955808   41 ITLPQFTALSVLASKSNLSNAKLAERSFIKPQSANKILQDLLVNGWIEKKPDPTHGRRI 99
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK14165 PRK14165
winged helix-turn-helix domain-containing protein/riboflavin kinase; Provisional
 31-111 1.78e-03

winged helix-turn-helix domain-containing protein/riboflavin kinase; Provisional


Pssm-ID: 184548 [Multi-domain]  Cd Length: 217  Bit Score: 36.97  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515955808  31 HLTEHLKELEItlpqftaLSVLASKSNLSNAKLAERSFIKPQSANKILQDLLVNGWIEKKPDPthgRRILITLTDSGIDK 110
Cdd:PRK14165   2 PDIEALKKLAL-------LGAVNNTVKISSSEFANHTGTSSKTAARILKQLEDEGYITRTIVP---RGQLITITEKGLDV 71


                 .
gi 515955808 111 L 111
Cdd:PRK14165  72 L 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH