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Conserved domains on  [gi|515960789|ref|WP_017391372|]
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MULTISPECIES: Na+/H+ antiporter subunit G [Acinetobacter]

Protein Classification

cation:proton antiporter( domain architecture ID 10003540)

cation:proton antiporter functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume; similar to Alkalihalophilus pseudofirmus Na(+)/H(+) antiporter subunit G

Gene Ontology:  GO:0015297|GO:0098662|GO:1902600
PubMed:  12027219|16734752|12502567|17218973|9537504
TCDB:  2.A.63

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MnhG COG1320
Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];
4-112 7.64e-35

Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];


:

Pssm-ID: 440931  Cd Length: 110  Bit Score: 116.50  E-value: 7.64e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   4 VMEIIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFaFQGRFGFAELLITLLAFITAPVS 83
Cdd:COG1320    1 ILEILVAVLLLLGALFALVGAIGLLRLPDFYTRLHAATKATTLGLGLILLGVALYF-GSGAVSLKLLLIILFLLLTAPVA 79

                         90       100
                 ....*....|....*....|....*....
gi 515960789  84 ANLIAQAALHLRLRSLSGEVPEAIERPLP 112
Cdd:COG1320   80 AHLLARAAYRSGVPPWEKTVVDELAEDLD 108
 
Name Accession Description Interval E-value
MnhG COG1320
Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];
4-112 7.64e-35

Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];


Pssm-ID: 440931  Cd Length: 110  Bit Score: 116.50  E-value: 7.64e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   4 VMEIIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFaFQGRFGFAELLITLLAFITAPVS 83
Cdd:COG1320    1 ILEILVAVLLLLGALFALVGAIGLLRLPDFYTRLHAATKATTLGLGLILLGVALYF-GSGAVSLKLLLIILFLLLTAPVA 79

                         90       100
                 ....*....|....*....|....*....
gi 515960789  84 ANLIAQAALHLRLRSLSGEVPEAIERPLP 112
Cdd:COG1320   80 AHLLARAAYRSGVPPWEKTVVDELAEDLD 108
PRK12674 PRK12674
putative monovalent cation/H+ antiporter subunit G; Reviewed
 3-97 9.87e-33

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 237169  Cd Length: 99  Bit Score: 110.69  E-value: 9.87e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   3 FVMEIIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAfQGRFGFAELLITLLAFITAPV 82
Cdd:PRK12674   1 TILEIIVSVLLLLGAFFALVGAIGLVRLPDVYTRLHAATKATTLGLGLVLLASALYFA-GGGNSLKALLIILFLFLTAPV 79

                         90
                 ....*....|....*
gi 515960789  83 SANLIAQAALHLRLR 97
Cdd:PRK12674  80 AAHLLARAAYRTGVP 94
PhaG_MnhG_YufB pfam03334
Na+/H+ antiporter subunit; This family includes PhaG from Rhizobium meliloti, MnhG from ...
 12-92 1.31e-26

Na+/H+ antiporter subunit; This family includes PhaG from Rhizobium meliloti, MnhG from Staphylococcus aureus, YufB from Bacillus subtilis.


Pssm-ID: 460887  Cd Length: 82  Bit Score: 94.82  E-value: 1.31e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   12 FLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPVSANLIAQA 90
Cdd:pfam03334   1 LLLLGAFFALVGAIGLLRLPDVYTRLHAATKADTLGLGLILLGLALYFGLgGGGVALKLLLIILFLLLTAPVAAHLIARA 80


                  ..
gi 515960789   91 AL 92
Cdd:pfam03334  81 AY 82
CPA3_mnhG_phaG TIGR01300
monovalent cation/proton antiporter, MnhG/PhaG subunit; This model represents a subfamily of ...
 11-93 4.14e-22

monovalent cation/proton antiporter, MnhG/PhaG subunit; This model represents a subfamily of small, transmembrane proteins believed to be components of Na+/H+ and K+/H+ antiporters. Members, including proteins designated MnhG from Staphylococcus aureus and PhaG from Rhizobium meliloti, show some similarity to chain L of the NADH dehydrogenase I, which also translocates protons. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130367  Cd Length: 97  Bit Score: 83.91  E-value: 4.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   11 VFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPVSANLIAQ 89
Cdd:TIGR01300   1 VLLLIGAFFTLLGAIGLVRFPDVYTRLHAATKGTTLGTILILLGVALIALVlDLAVSIKLLLIALFILLTNPVGAHLLAR 80


                  ....
gi 515960789   90 AALH 93
Cdd:TIGR01300  81 AAYL 84
 
Name Accession Description Interval E-value
MnhG COG1320
Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];
4-112 7.64e-35

Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism];


Pssm-ID: 440931  Cd Length: 110  Bit Score: 116.50  E-value: 7.64e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   4 VMEIIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFaFQGRFGFAELLITLLAFITAPVS 83
Cdd:COG1320    1 ILEILVAVLLLLGALFALVGAIGLLRLPDFYTRLHAATKATTLGLGLILLGVALYF-GSGAVSLKLLLIILFLLLTAPVA 79

                         90       100
                 ....*....|....*....|....*....
gi 515960789  84 ANLIAQAALHLRLRSLSGEVPEAIERPLP 112
Cdd:COG1320   80 AHLLARAAYRSGVPPWEKTVVDELAEDLD 108
PRK12674 PRK12674
putative monovalent cation/H+ antiporter subunit G; Reviewed
 3-97 9.87e-33

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 237169  Cd Length: 99  Bit Score: 110.69  E-value: 9.87e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   3 FVMEIIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAfQGRFGFAELLITLLAFITAPV 82
Cdd:PRK12674   1 TILEIIVSVLLLLGAFFALVGAIGLVRLPDVYTRLHAATKATTLGLGLVLLASALYFA-GGGNSLKALLIILFLFLTAPV 79

                         90
                 ....*....|....*
gi 515960789  83 SANLIAQAALHLRLR 97
Cdd:PRK12674  80 AAHLLARAAYRTGVP 94
PRK12671 PRK12671
putative monovalent cation/H+ antiporter subunit G; Reviewed
 7-108 2.56e-28

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183670  Cd Length: 120  Bit Score: 100.10  E-value: 2.56e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   7 IIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPVSAN 85
Cdd:PRK12671  13 ILVAFFLVLGAGLTLIGTIGLVRLKSFYERLHAPTLGTSWGAGGILIASILYFSVlQSRPVLHEVLIGVFVVVTTPVTLM 92

                         90       100
                 ....*....|....*....|...
gi 515960789  86 LIAQAALHLRLRSLSGEVPEAIE 108
Cdd:PRK12671  93 LLSRAALYRDRSEDSSEKPSALE 115
PhaG_MnhG_YufB pfam03334
Na+/H+ antiporter subunit; This family includes PhaG from Rhizobium meliloti, MnhG from ...
 12-92 1.31e-26

Na+/H+ antiporter subunit; This family includes PhaG from Rhizobium meliloti, MnhG from Staphylococcus aureus, YufB from Bacillus subtilis.


Pssm-ID: 460887  Cd Length: 82  Bit Score: 94.82  E-value: 1.31e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   12 FLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPVSANLIAQA 90
Cdd:pfam03334   1 LLLLGAFFALVGAIGLLRLPDVYTRLHAATKADTLGLGLILLGLALYFGLgGGGVALKLLLIILFLLLTAPVAAHLIARA 80


                  ..
gi 515960789   91 AL 92
Cdd:pfam03334  81 AY 82
CPA3_mnhG_phaG TIGR01300
monovalent cation/proton antiporter, MnhG/PhaG subunit; This model represents a subfamily of ...
 11-93 4.14e-22

monovalent cation/proton antiporter, MnhG/PhaG subunit; This model represents a subfamily of small, transmembrane proteins believed to be components of Na+/H+ and K+/H+ antiporters. Members, including proteins designated MnhG from Staphylococcus aureus and PhaG from Rhizobium meliloti, show some similarity to chain L of the NADH dehydrogenase I, which also translocates protons. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130367  Cd Length: 97  Bit Score: 83.91  E-value: 4.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   11 VFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPVSANLIAQ 89
Cdd:TIGR01300   1 VLLLIGAFFTLLGAIGLVRFPDVYTRLHAATKGTTLGTILILLGVALIALVlDLAVSIKLLLIALFILLTNPVGAHLLAR 80


                  ....
gi 515960789   90 AALH 93
Cdd:TIGR01300  81 AAYL 84
PRK12586 PRK12586
Na+/H+ antiporter subunit G;
4-91 3.72e-18

Na+/H+ antiporter subunit G;


Pssm-ID: 237147  Cd Length: 145  Bit Score: 75.20  E-value: 3.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   4 VMEIIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAF-QGRFGFAELLITLLAFITAPV 82
Cdd:PRK12586   7 IFSLIAAIMILLGSIIALISAIGIVKFQDVFLRSHAATKSSTLSVLLTLIGVLIYFIVnTGFFSVRLLLSLVFINLTSPV 86


                 ....*....
gi 515960789  83 SANLIAQAA 91
Cdd:PRK12586  87 GMHLIARAA 95
PRK12585 PRK12585
putative monovalent cation/H+ antiporter subunit G; Reviewed
 1-97 3.87e-17

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183610  Cd Length: 197  Bit Score: 73.56  E-value: 3.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   1 MQFVMEIIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAFQGR-FGFAELLITLLAFIT 79
Cdd:PRK12585   1 MNVIIEIIISIMILIGGLLSILAAIGVIRLPDVYTRTHAAGISNTFGVSLLLFATVGYFFHSGEgFNARVLLAVLFIFLT 80

                         90       100
                 ....*....|....*....|....
gi 515960789  80 APVSANLIAQAA------LHLRLR 97
Cdd:PRK12585  81 TPVASHLINRAAydtgvpLAIRIR 104
PRK12672 PRK12672
putative monovalent cation/H+ antiporter subunit G; Reviewed
 4-91 6.61e-11

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183671  Cd Length: 118  Bit Score: 55.49  E-value: 6.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   4 VMEIIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAFQGRFG----FAEL----LITLL 75
Cdd:PRK12672   2 MIEYLIYIFLAIGVTFNLLGSIALHRFPDVYTRLHGATKCTTFGTIFAVLAVVTHALYRLRLTgdpkYLQMalhsFVALI 81

                         90
                 ....*....|....*..
gi 515960789  76 AF-ITAPVSANLIAQAA 91
Cdd:PRK12672  82 ALlLTNPVGAHAIARAA 98
PRK12587 PRK12587
putative monovalent cation/H+ antiporter subunit G; Reviewed
 7-95 1.21e-10

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183612  Cd Length: 118  Bit Score: 54.79  E-value: 1.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   7 IIVSVFLIF---GAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAFQGRFGFAELLITLL-AFITAPV 82
Cdd:PRK12587   5 ILISLALIFviiGALISALAAIGLLRLEDVYSRAHAAGKASTLGAMSLLFGTFLYFIATQGYVNMQLIVGIIfVLITGPL 84

                         90
                 ....*....|...
gi 515960789  83 SANLIAQAALHLR 95
Cdd:PRK12587  85 SSHMIMKAAYNIK 97
PRK12675 PRK12675
putative monovalent cation/H+ antiporter subunit G; Reviewed
 7-91 9.63e-09

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 171652  Cd Length: 104  Bit Score: 49.40  E-value: 9.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   7 IIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIF--FAFQGRFGFAELLItLLAFITaPVSA 84
Cdd:PRK12675   1 MIELLFLLFGYSIMFFGALGLLRFPDVYTRLHAATKCDTGGAMGIILALALAsdASLLIKLKFLVLAF-LIAMIN-PMVS 78


                 ....*..
gi 515960789  85 NLIAQAA 91
Cdd:PRK12675  79 HAIARGA 85
PRK12592 PRK12592
putative monovalent cation/H+ antiporter subunit G; Reviewed
 2-91 1.88e-08

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183613  Cd Length: 126  Bit Score: 49.48  E-value: 1.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   2 QFVMEIIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIASMIFFAFQGRFGFAE-------LLITL 74
Cdd:PRK12592   4 QLFTDIVSLVFILSGAFLSFSASIGLIRFRDTMSRVHAITKPQTTGLILTVVGAIIRVLGHEDFDQSQrgdlgvlVLLVL 83

                         90
                 ....*....|....*..
gi 515960789  75 LAFITAPVSANLIAQAA 91
Cdd:PRK12592  84 FALLTSPVTAQRVGRVS 100
PRK12670 PRK12670
putative monovalent cation/H+ antiporter subunit G; Reviewed
 4-93 2.73e-07

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 183669  Cd Length: 99  Bit Score: 45.48  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   4 VMEIIVSVFLIFGAFFMLVGSIGMVRLPDLFMRLHAPTKSSTLGLGSFLIAsmifFAFQGRFGFAELLITLLAF---ITA 80
Cdd:PRK12670   1 MLPMLGMITLGLGIFLIVISVIGVIRFPDFYTRLHAAGITDSLGAALILIG----LAMQCGFSVFTVKVLLLICllwITS 76

                         90
                 ....*....|...
gi 515960789  81 PVSANLIAQAALH 93
Cdd:PRK12670  77 TTASYALARSAYK 89
PRK06286 PRK06286
putative monovalent cation/H+ antiporter subunit G; Reviewed
 1-93 2.63e-03

putative monovalent cation/H+ antiporter subunit G; Reviewed


Pssm-ID: 235769  Cd Length: 91  Bit Score: 35.01  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515960789   1 MQFVMEIIVSVFLIFGAFFMLVGSIGMVRLPD-----LFMRLHAptksstlgLGSFLIASMIFFafqgrFGFAELLITLL 75
Cdd:PRK06286   1 MMQFVGIIQDILLIIASIGILIASIRLWRVEKdrknvVYARIHI--------LGVIDIACILIL-----LALGQPLLALT 67

                         90
                 ....*....|....*...
gi 515960789  76 AFITAPVSANLIAQAALH 93
Cdd:PRK06286  68 YLILAPFLAHAIANAHYN 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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