|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
6-414 |
8.43e-97 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 294.09 E-value: 8.43e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSI 85
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAF 165
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 166 MIIASIGIVWMLVWFFtaadnpekshrvteherqwvnrlktekindeedltqsaqtlgyYLRQpiILVTAFAFFCYNYIL 245
Cdd:cd17319 161 IIEGLLGLLLAVLWWF-------------------------------------------YLRQ--VWGLALGYFGINYAL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 246 FFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNltgrllLSRKIVLVVSLLAAAICVALAGVVT 325
Cdd:cd17319 196 YGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR------GARRLVIIIGLLLAAVGLLLAYLTT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 326 RVVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVAA 405
Cdd:cd17319 270 SPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVAL 349
|
....*....
gi 516061811 406 LGAILVFFV 414
Cdd:cd17319 350 LAALLVLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
15-415 |
2.09e-93 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 286.93 E-value: 2.09e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 15 LVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIAT 94
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 95 GFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIV 174
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 175 WMLVWFFTAADNPEKSHRVTEHERQWVNRLKTEKINDEEDLTQSAQTLGYYLRQPIILVTAFAFFCYNYILFFFLSWFPA 254
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 255 YLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNLTGRLLLSRKIVlVVSLLAAAICVALAGVVTRVVPAVMLM 334
Cdd:TIGR00893 241 YLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTA-IIAGLVLSLLMFATNYVNIPYAALALV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 335 SVSIFFLYtTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVAALGAILVFFV 414
Cdd:TIGR00893 320 ALGFFGLG-AGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLLL 398
|
.
gi 516061811 415 I 415
Cdd:TIGR00893 399 V 399
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-419 |
1.31e-74 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 237.46 E-value: 1.31e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 3 KNLRWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGL 82
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 83 WSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWR 162
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 163 PAFMIIASIGIVWMLVWFftaadnpekshrvteherqwvnrlktekindeedltqsaqtlgyylrqpiiLVTAFAFFCYN 242
Cdd:COG2271 165 AAFLILGLPGLLLALLRF---------------------------------------------------WLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 243 YILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNltgrlllSRKIVLVVSLLAAAICVALAG 322
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR-------RRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 323 VVTRVVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGhFDSAFILAGG 402
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAA 345
|
410
....*....|....*..
gi 516061811 403 VAALGAILVFFVIKPPK 419
Cdd:COG2271 346 LALLAALLALLLLRETR 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-424 |
1.87e-56 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 190.86 E-value: 1.87e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSI 85
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAF 165
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 166 MIIASIGIVWMLVWFFTAADNPEKSHRVTeherqwvnrlktekindeedlTQSAQTLGYYLRQPIILVTAFAFFCYNYIL 245
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAA---------------------KASLRDQLEALRDPRFWLLSLLYFGTFGSF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 246 FFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAGVVT 325
Cdd:COG2223 222 IGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI---------GGRRVLLIVFALMALGLLLLALAL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 326 RVVPAVMLMSVSIFFLYTTG-AIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVA 404
Cdd:COG2223 293 GSLWLFLVLFLLLGLALGGGnGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLA 372
|
410 420
....*....|....*....|
gi 516061811 405 ALGAILVFFVIKPPKHQPQT 424
Cdd:COG2223 373 LVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
10-415 |
1.63e-54 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 185.07 E-value: 1.63e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 10 VLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGM 89
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 90 T--AIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMI 167
Cdd:cd17380 81 TplLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 168 IASIGIVWMLVWFFTAadnpekshrvteherqwvnrlktekindeedltqsaqtlgyylrqPIILVTAFAFFCYNYILFF 247
Cdd:cd17380 161 FGLLGLLWALVWLIYL---------------------------------------------PPVWAIIVAHFCMNWGFYI 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 248 FLSWFPAYLVQAHGlNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNLTGRLLLSRKIVLVVSLLAAAICVALAGVVTRV 327
Cdd:cd17380 196 LLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSF 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 328 VPAVMLMSVSIFFLYTTGAIYWAIIQDVVhKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVAALG 407
Cdd:cd17380 275 SLALLCMSVALGLSAFSSSGVLVNHQDIA-PNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVG 353
|
....*...
gi 516061811 408 AilVFFVI 415
Cdd:cd17380 354 A--VVFLL 359
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
15-391 |
1.45e-40 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 148.29 E-value: 1.45e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 15 LVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIAT 94
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 95 GFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGY-LAISFGWRPAFMIIASIGI 173
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 174 VWMLVWFFTAADNPEkSHRVTEHERQWVNRLKTEKINDEEDLTQSAQTLGYYLRQPIILVTAFAFFCYNYILFFFLSWFP 253
Cdd:TIGR00881 162 IVSLICFLLLRDSPQ-SCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 254 AYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNLTGRLL-LSRKIVLVVSLLAAAICVALAGVVTrvvpaVM 332
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLaVFFMALIIVSLLVYWLNPAANPLMD-----LI 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 516061811 333 LMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTG 391
Cdd:TIGR00881 316 CLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
11-415 |
2.67e-37 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 139.68 E-value: 2.67e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 11 LLLCLVYMINYLDRVALSIT-VPMIEKELTI---------------------NPEQFGMIFGSFFFGYAIFNFLGGLAVD 68
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAiVAMVNSTATHdnnntstdkdtlpveapefdwSEKTQGIILSSFFYGYILTQIPGGYLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 69 KFGPTLVMGLAVGLWSIFCGMTAIAT--GFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGA 146
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 147 VAGPIVGYLAISFGWRPAFMIIASIGIVWMLVWFFTAadnpekshrvteherqwvnrlktekindeedltqsaqtlgyyl 226
Cdd:cd17318 162 IAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV------------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 227 rqPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDK-IFNLTGRLLLSRKI 305
Cdd:cd17318 199 --LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWlRSRGILSTTTVRKL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 306 VLVVSLLAAAIC-VALAGVVTRVVPAVMLMSVSIFF--LYTTGAIywAIIQDVVhKSKVGSASGFIHLIGSVSGIIGPIA 382
Cdd:cd17318 277 FTSIGFLGPGVFlIALGYLGSNATLAVVFLTLSVGLsgACYSGFL--VNHLDLA-PNYAGTLMGITNTAATIAGIISPLI 353
|
410 420 430
....*....|....*....|....*....|....*.
gi 516061811 383 TGFIVQNTGHFDS---AFILAGGVAALGAIlvFFVI 415
Cdd:cd17318 354 VGAIVKNDQTIGQwriVFFISAAIYILGAI--FYLI 387
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-376 |
1.40e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 137.03 E-value: 1.40e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSI 85
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAF 165
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 166 MIIASIGIV-WMLVWFFTAADNPEKSHRVteherqwvnrlktekindeedltqsAQTLGYYLRQPIILVTAFAFFCYNYI 244
Cdd:COG2814 168 LVNAVLALLaLLLLLRLLPESRPAARARL-------------------------RGSLRELLRRPRLLLLLLLAFLLGFG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 245 LFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAGVV 324
Cdd:COG2814 223 FFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF---------GRRRLLLIGLLLLALGLLLLALA 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 516061811 325 TRVVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSG 376
Cdd:COG2814 294 GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-412 |
6.17e-36 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 136.02 E-value: 6.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 13 LCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAI 92
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 93 ATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLA--ISFGWRPAFMIIAS 170
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 171 IGIVWMLVWFFTAADNPEkshrvteherqwvnrlKTEKINDEEDLTQSAQTLGYYLRQPIILVTAFAFFCYNYILFFFLS 250
Cdd:cd06174 161 LALLAAILLLLVVPDPPE----------------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFST 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 251 WFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFnltgrlllSRKIVLVVSLLAAAICVALAGVVTRVVPA 330
Cdd:cd06174 225 LLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI--------GRKPLLLIGLLLMALGLALLLLAPSLLLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 331 VMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVAALGAIL 410
Cdd:cd06174 297 LLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
..
gi 516061811 411 VF 412
Cdd:cd06174 377 LL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-380 |
3.39e-35 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 132.93 E-value: 3.39e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 13 LCLVYMINYLDRVALSITVPM-IEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTA 91
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 92 IATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASI 171
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 172 GIVWMLVWFFtaadnpekshrvteherqWVNRLKTEKINDEEDLTQSAQTLGYYLRQPIILVTAFAFFCYNYILFFFLSW 251
Cdd:pfam07690 161 SLLAAVLLLL------------------PRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTY 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 252 FPAYlVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNLTgrlllsRKIVLVVSLLAAAICVALAGVVTRVVPAV 331
Cdd:pfam07690 223 LPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR------RLLLALLLLILAALGLLLLSLTLSSLWLL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 516061811 332 MLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGP 380
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
10-386 |
2.36e-33 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 129.28 E-value: 2.36e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 10 VLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGM 89
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 90 TAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISF-GWRPAFMII 168
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 169 ASIGIVWMLVWFFTAADnPEKSHRVTEHERQWVNrlktekindeedlTQSAQTLGYYLRQPIILVTAFAFFCYNYILFFF 248
Cdd:cd17328 161 GVLGVLLAILLLLFVRE-PPRGAAEGGVMAKSTA-------------TSFLADLKALAKNPSFILSTLGFTAVSFVTGAL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 249 LSWFPAYLVQAHGLNIKEMSLTTVIPWIV----GFFGLALGGIISDKIFNLTGRlllSRKIVLVVSLLAAAICVALAGVV 324
Cdd:cd17328 227 AFWAPTFFLRAFGVGDLSSADVGLIFGAItciaGVLGVLLGGILADRLRRKTPR---ADPLVCAVGLLAAAPFLFLALVL 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516061811 325 TR--VVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASG----FIHLIGSVsgiIGPIATGFI 386
Cdd:cd17328 304 ALsnLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAiqilLSHLLGDA---GSPYLIGLI 368
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
6-412 |
5.65e-31 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 122.00 E-value: 5.65e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMG---LAVGL 82
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSaglLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 83 WSIFCGMTaiaTGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWR 162
Cdd:cd17312 81 ANIFMGFS---TSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 163 PAFMIIASIGIVWMLVWFFTAADNPekshrvteherqwvnrlktekindeedltqsaqtlgyylrqPIILVTAFAFFCYN 242
Cdd:cd17312 158 AAFLVPGIVGLVVAIILFFFLRDSP-----------------------------------------PYVWVLSLAYAFVY 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 243 YILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNLTGRLLlsrkIVLVVSLLAAAICVALAG 322
Cdd:cd17312 197 IVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPI----AVIYMLLMTLSLALFWFF 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 323 VVTRVVPAVmLMSVSIFFLYTTGAIYWAIIQDVVHKSKV-GSASGFIHLIGSVSGIIGPIATGFIVQNTGhFDSAFILAG 401
Cdd:cd17312 273 PHNKLLSIV-LLFLIGFFVGGPINLIGGAAAQDIGRKEAaGTATGFVGLFGYLGASLAGLPLGYIIDHYG-WSTVFYFLI 350
|
410
....*....|.
gi 516061811 402 GVAALGAILVF 412
Cdd:cd17312 351 SAALLSVLLLL 361
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
30-411 |
9.78e-30 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 118.88 E-value: 9.78e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 30 TVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMA 109
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 110 EGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIVWMLVwFFTAADNPEK 189
Cdd:cd17475 98 YGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVL-FWLFYREPPA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 190 SHRVTEHERQWVNRLKTekindeedltqsaqtlgyYLRQPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSL 269
Cdd:cd17475 177 ASAATESASTLLRSLKE------------------VLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 270 TTVIPWIVGFFGLALGGIISDKIFNltGRlllsRKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSVSIFFLYTT---GA 346
Cdd:cd17475 239 LLAVAQLGGALGRIGLGRVSDRVFG--GR----RRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAigwNG 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516061811 347 IYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVAALGAILV 411
Cdd:cd17475 313 LYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
7-382 |
1.07e-28 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 116.19 E-value: 1.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 7 WIIVLLLCLVYMINYLDRVALSITVPM-IEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSI 85
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAG-------PIVGYLAIS 158
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGllaygvfKILGVGGLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 159 fGWRPAFMIIASIGIVWMLVWFFTAADNPEKSHRVTEHERQW-VNRLKTEKINDEEDLTQSAQTLgYYLRQPIILVTAFA 237
Cdd:cd17327 164 -GWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELaVERLRANQTGKGDQKFKWKQIK-EAFKDPRTWLLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 238 FFCYNYILFFFLSWFPAyLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNltgrlllsRKIVLVVSLLAAAIC 317
Cdd:cd17327 242 FFCSQITNNGISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKK--------RGLFAIFACVLALVG 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516061811 318 VALAGVVTRVVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHK-SKVGSASGFIHLIGSVSGIIGPIA 382
Cdd:cd17327 313 SIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGyTKRATVLAIMLIFYNVGNIVAPQI 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-421 |
2.21e-28 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 115.34 E-value: 2.21e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 1 MFKNLRWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAV 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 81 GLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKqAATAMGLLSAGSPLgGAVAGPIVGYLAISFG 160
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSL-GALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 161 ----WRPAFMIIASIGIVWMLVWFFTAADNPEKshrvteherqwvnrlktekinDEEDLTQSAQTLGYYLRQPIILVTAF 236
Cdd:COG0738 159 lslsWHLPYLILAVLLLLLALLFLRSKLPEIEE---------------------EEEEAAGSAASLKSLLKNPRLLLGGL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 237 AFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAI 316
Cdd:COG0738 218 AIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF---------GPVRLLRLSALLAAV 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 317 CVALAGVVTRVVPAVM-LMSVSIFFLYTTGAIYWAIIQDVvhKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGhFDS 395
Cdd:COG0738 289 GLLLALLAPGPWLALIgLALVGLGLSLMFPTIFSLALDGL--GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRA 365
|
410 420
....*....|....*....|....*.
gi 516061811 396 AFILAGGVAALGAILVFFVIKPPKHQ 421
Cdd:COG0738 366 AFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
4-387 |
5.32e-28 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 114.38 E-value: 5.32e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 4 NLRWIIVLLLC-LVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGL 82
Cdd:TIGR00895 12 SRYQWRAIILSfLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 83 WSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWR 162
Cdd:TIGR00895 92 FSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 163 PAFMI--IASIGIVWMLVWF------FTAADNPEKSHRVTEHERQWVNRLKTEKINDEEDLTQSAQTL------GYYLRQ 228
Cdd:TIGR00895 172 SLFYVggIAPLLLLLLLMRFlpesidFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVfkalfqGKTARI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 229 PIILVtaFAFFCYNYILFFFLSWFPAYLVQAhGLNIKEMSLTTVIPWIVGFFGLALGGIISDKifnltgrllLSRKIVLV 308
Cdd:TIGR00895 252 TVLLW--LLYFMLLVGVYFLTNWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADR---------LGPRVTAL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 309 VSLLAAAICVALAGVVTRvvPAVMLMSVSIFFLYTTGAI--YWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFI 386
Cdd:TIGR00895 320 LLLLGAVFAVLVGSTLFS--PTLLLLLGAIAGFFVNGGQsgLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
.
gi 516061811 387 V 387
Cdd:TIGR00895 398 L 398
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-422 |
3.70e-27 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 111.89 E-value: 3.70e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSI 85
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKqAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAF 165
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 166 MIIASIGIVWMLVWFFTAADNPEKSHRvteherqwvnrlktekindeedlTQSAQTLGYYLRQPIILVTAFAFFCYNYIL 245
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRRPAAAAA-----------------------APAAASLRSLWRSPLAWLLTLFFGLQSLLY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 246 FFFLSWFPAYLVQAHglnikeMSLTTvIPWIVGFFGLA--LGGIIsdkIFNLTGRLLLSRKIVLVVSLLAAAICVALAGV 323
Cdd:COG2807 232 YAVVAWLPPILRDAG------LSAAT-AGLLLSLFQLAgiPGSLL---VPLLADRLGDRRPLLLLLGLLGLAGLLGLLLA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 324 VTRV-VPAVMLMSVSIFFLYTTGAIYwaIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGG 402
Cdd:COG2807 302 PGSLpWLWAVLLGLGQGGLFPLALTL--IGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAA 379
|
410 420
....*....|....*....|
gi 516061811 403 VAALGAILVFFVIKPPKHQP 422
Cdd:COG2807 380 LAVLMLVAGLLAGRPYVEDA 399
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
36-415 |
5.15e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 111.13 E-value: 5.15e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 36 KELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICA 115
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 116 SANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFmIIASIGIVWMLVWFFTAADNPEKSHRVTE 195
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF-LVCAALALLALVLALLLLPEPRPPPNKRA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 196 HERQWVNRLKTEKindeedltqsaqtlgyyLRQPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPW 275
Cdd:cd17325 183 VSAARLRSGLRLL-----------------LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 276 IVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSVSIFFLYTTGAIYWAIIQDV 355
Cdd:cd17325 246 LASALSQPPAGKLSDRI---------GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 356 VHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFdSAFILAGGVAALGAILVFFVI 415
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA-TPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
10-412 |
4.80e-23 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 99.58 E-value: 4.80e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 10 VLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGM 89
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 90 TAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIA 169
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 170 SIGIVWMLVWFFTaadnpekshrvteherqwvnrlktekindeedltqsaqtlgyylrqpiiLVTAFAFFCYNYILFFFL 249
Cdd:cd17365 161 VPPLILLPLLRGT-------------------------------------------------LLLWVTFFMGLLLVYLLN 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 250 SWFPaYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAGVVTRVVP 329
Cdd:cd17365 192 SWLP-KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRF---------GPKRVLALFFALGAVSLALLGVSPASLV 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 330 AV-MLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVAALGA 408
Cdd:cd17365 262 LLyVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGA 341
|
....
gi 516061811 409 ILVF 412
Cdd:cd17365 342 LAVL 345
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
13-413 |
5.60e-23 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 99.70 E-value: 5.60e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 13 LCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFG--PTLVMGLAVGLWSIFcGMT 90
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGrrRTLILGLLLISLALA-LIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 91 AiATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAaTAMGLLSAGSPLGGAVAGPIVGYL-AISFGWRPAFMIIA 169
Cdd:cd17333 80 A-TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSA-TRLNVLHGFFGLGALIGPLIATSLlTSELSWSWAYLIIG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 170 SIGIVWMLVWFFTAADNPEKSHRVTEHERQWVNRLKTEkindeedltqsaqtlgyyLRQPIILVTAFAFFCYNYILFFFL 249
Cdd:cd17333 158 LIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRL------------------LRNPSIILGALALFLYVGAETAFS 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 250 SWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrllLSRKIVLVVSLLAAAICVALAGVVTRVVP 329
Cdd:cd17333 220 SWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI--------KPHTLLVLSGSGALLGLLILLLAPTLVVG 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 330 AVMLMSVSIFF--LYTTGAIYWAIIqdvvHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGhFDSAFILAGGVAALG 407
Cdd:cd17333 292 LVATALLGLFMaaLFPTILSLGISN----LPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVG-IQTAMLLITILYAII 366
|
....*.
gi 516061811 408 AILVFF 413
Cdd:cd17333 367 FVLALL 372
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
32-414 |
2.71e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 97.64 E-value: 2.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 32 PMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEG 111
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 112 PICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVaGPIVGYLAISFGWRPAFMIIASIGIVWMLVWFFTaadnPEKSH 191
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAV-GPLLGGLLAAISWRYPFFLLAALIPVAFLAILFL----LPEPK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 192 RVTEHERQWVNRLKTEkindeedltqsaqtlgyYLRQPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNikemsltt 271
Cdd:cd17474 178 EKAKSSSATKLRDLKK-----------------ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS-------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 272 viPWIVG--FFGLALGGIISDKIFNLTGRLLLSRKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSVSIFFLYTTGAIYW 349
Cdd:cd17474 233 --PIIIGllFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516061811 350 AIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHfDSAFILAGGVAALGAILVFFV 414
Cdd:cd17474 311 TLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGL-SAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
10-412 |
8.05e-22 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 95.75 E-value: 8.05e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 10 VLLLCLVYMINYLDRVALSITVPMIEKE--LTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFC 87
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 88 GMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSA----GSPLGGAVAGPIVGYLAISFGWRP 163
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSgwalGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 164 AFMIIASIGIvwmlvwfftaadnpekshrvteherqwvnrlktekindeedltqsaqtLGYYLRQPIILVTAFaFFCYNY 243
Cdd:cd17316 161 LFLIGALPAL------------------------------------------------LALLLRRRTLLLILL-WFFISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 244 ILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAGV 323
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI---------GRKKTLVIGLILSGILALPLFY 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 324 VTRVVPAVMLMSVSI--FFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAG 401
Cdd:cd17316 263 LLSGSPTLLLLLLFIlsFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILA 342
|
410
....*....|.
gi 516061811 402 GVAALGAILVF 412
Cdd:cd17316 343 LLAIVALIVAL 353
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
6-414 |
1.88e-21 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 95.77 E-value: 1.88e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSI 85
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIA----TGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFG- 160
Cdd:cd17345 81 INILIGFVpsatSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 161 --WRPAFMIIASIGIVWMLVWFFTAADNPEKS--HRVTEHERQWVNRLKTEKinDEEDLTQSAQTLGYYLRQPIILVTAF 236
Cdd:cd17345 161 gwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEglPPIEEYKGDYPEEADGEE--EEQELSAWEIFVKYVLKNKLLWYIAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 237 A-FFCYnYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNltGRlllsRKIVLVVSLLAAA 315
Cdd:cd17345 239 AnVFVY-LVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFK--GR----RAPTGIIFMILVI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 316 ICValagVVTRVVPAVMLMSVSIFFL----YTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSG-IIGPIATGFIVQNT 390
Cdd:cd17345 312 VAL----IVYWLAPNVLVDLIALIALgfliYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGsVLATALIGIIVDHF 387
|
410 420
....*....|....*....|....
gi 516061811 391 GhFDSAFILAGGVAALGAILVFFV 414
Cdd:cd17345 388 G-WNGGFIVLLASCILAIIFLALV 410
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
41-415 |
2.77e-21 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 94.85 E-value: 2.77e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 41 NPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIAT--GFYSMLILRVLFGMAEGPICASAN 118
Cdd:cd17381 63 DAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAAdlGAGYLIAVRALEGLGEGVTFPAMH 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 119 KMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIVWMLVWFFtaadnpekshrvteher 198
Cdd:cd17381 143 AMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIW----------------- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 199 qwvnrlktekindeedltqsaqtlgyyLRQPIILVTAfAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVG 278
Cdd:cd17381 206 ---------------------------LVMPLWAIVV-AHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGC 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 279 FFGLALGGIISDkifNLTGRLLLS----RKIVLVVSLLAAAICVALAGVV-TRVVPAVMLMSVSIFFLYTTGAIYwAIIQ 353
Cdd:cd17381 258 WLFMILSGQIAD---NLREKQNFStvcvRKIFTLIGMIGPAVFLLAAGFTgCNYSLAVAFLTISSTLGGFSASGF-NINH 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516061811 354 DVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQN--TGHFDSAFILAGGVAALGAIlvFFVI 415
Cdd:cd17381 334 LDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTHNntVEEWQTVFYISAAINVFGAI--FFTI 395
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
2-416 |
5.98e-21 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 94.81 E-value: 5.98e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 2 FKNLRWIIVLLLCLVYMINYLDRVALSIT-VPMIEKELTI---------------------NPEQFGMIFGSFFFGYAIF 59
Cdd:TIGR00894 13 FCSFRLFLSFLLHICNVIIIAQRICLSLTmVAMVNKENSTdlaclsaeneldniknpnfkwSGALQGLILSSHFYGQIII 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 60 NFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIAT--GFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLL 137
Cdd:TIGR00894 93 QIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAggGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 138 SAGSPLGGAVAGPIVGYLAISF-GWRPAFMIIASIGIVWMLVWFFTAADNPEKSHRVTEHERQWVNR-LKTEKINDEEDL 215
Cdd:TIGR00894 173 TSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSsLQGQKGSTRQSL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 216 TQSAQtlgyyLRQPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISD-KIFN 294
Cdd:TIGR00894 253 PIKAI-----PKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADfLKSS 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 295 LTGRLLLSRKIVLVVSLLAAAICValagvvtrvvpavmlmsvsIFFLYTTGAIYWAIIQDVVHKSKVGSA---------- 364
Cdd:TIGR00894 328 KTLSLTAARKIFNGIGGLGPGIFA-------------------YALPYLSAAFYLTIIILTLANAVSSGPlagvlinsld 388
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516061811 365 -----SGFIHLIGSVSGIIGPIATGFIVQNTGHFDS------AFILAGGVAALGAIlvFFVIK 416
Cdd:TIGR00894 389 laprfLGFIKGITGLPGFIGGLIASTLAGNILSQDSknvwliVFLIMAFVNILCVI--FYLIF 449
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
6-413 |
3.45e-20 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 92.01 E-value: 3.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVmgLAVGLwsI 85
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWL--FSSGL--V 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIATGFYSML----ILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGW 161
Cdd:cd17343 77 LSGLTTVAFSGSSSVwvfsILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 162 RPAFMIIASIGIVWMLVWFFTAADNPEkshrvtehERQWVNRLKTEKINDEEDLTQSAQTLGYYLRQPIILVTAFAFFCY 241
Cdd:cd17343 157 RSTLSISGTVAVVMSVVCLLFIKNEPS--------DVGLNNIEEEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 242 NYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNLTGRLLLSRKIVLVVSLLAAAICVALA 321
Cdd:cd17343 229 FGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLTVSLH 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 322 GVVTRVVPAVMLMSVSI------FFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGhFDS 395
Cdd:cd17343 309 LFRVHITSDSSELFILLlgfligFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYD-WRT 387
|
410
....*....|....*...
gi 516061811 396 AFILAgGVAALGAILVFF 413
Cdd:cd17343 388 AFLLL-EILCAITVVILF 404
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
6-414 |
4.07e-19 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 88.44 E-value: 4.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSI 85
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIATGFYSMLILR-VLFGMAEGPICASANKMINGWFPKKQAAtAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPA 164
Cdd:cd17353 81 GFILSAFAISLPLLFLGYgVLGGIGAGIGYITPVSTAVKWFPDKRGL-ATGIVIAGFGLGSLIFSPLIAYLINTVGVPTT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 165 FMIIASIGIVWMLVWFFTAADNPEKSHRVTeherqwVNRLKTEKINDEEDLTQSAQtlgyyLRQPIILVTAFAFFCYNYI 244
Cdd:cd17353 160 FLILGIIFLIIIVIGAFLIRDPPKGWVPPG------VDPLANNAENSPRDYTPREM-----LRTPTFWLLWLMFFLNATA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 245 LFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAGVV 324
Cdd:cd17353 229 GLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI---------GRKNTLSIAFLIQGVAMFLLPFI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 325 TRVVPAVMLMSVSIFFLYTTG-AIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFiVQNTGHFDSAFILAGGV 403
Cdd:cd17353 300 GSVAVLFVLGVALIGFCYGGGfALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFIIAAAL 378
|
410
....*....|.
gi 516061811 404 AALGAILVFFV 414
Cdd:cd17353 379 SLVALALALLL 389
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
7-414 |
6.74e-19 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 87.61 E-value: 6.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 7 WIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIF 86
Cdd:cd17352 2 WVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 87 CGMTAIATGFYS-MLILRVLFGMAEGPICASANKMINGWFPKKQAaTAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAF 165
Cdd:cd17352 82 LLLSSFATSLWQlYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRG-LATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 166 MIIASIgivwMLVWFFTAAdnpekshrvteherqwvnrlktekindeedltqsaqtLGYYLRQPIILVTAFAFFCYNYIL 245
Cdd:cd17352 161 LILGGL----CLNLCVCGL-------------------------------------LLRLLKDPTFVLLALGVSFAMLGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 246 FFFLSWFPAYLVQaHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlLLSRKIVLVVSLLAAAICVALAGVVT 325
Cdd:cd17352 200 FVPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLGLLADKP-------RIGRLYLYIFTLLILGLSLLAFPLAT 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 326 RVVPavmLMSVSIFFLYTTGAIY---WAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGG 402
Cdd:cd17352 272 TYVG---LIVFSVLFGFCSGSYSsltPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGA 348
|
410
....*....|..
gi 516061811 403 VAALGAILVFFV 414
Cdd:cd17352 349 CLLLSGVLLFLL 360
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
32-412 |
1.90e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 86.45 E-value: 1.90e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 32 PMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEG 111
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 112 PICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIVWMLVWFFTAADNPEKSH 191
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 192 RVTEHERQWVnrlktekindeeDLTQSAQTLGYYLrqpIILVTAFAFFC-YNYILFFflswfpayLVQAHGLNIKEMSLT 270
Cdd:cd17324 183 GSLGLLSSLL------------LLLRNPRLRLAYL---ITFLLFGGFFAlYTYLAPF--------LTDVPGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 271 TVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSVSIFFLYTTGAIYWA 350
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRG---------GRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516061811 351 IIQDVVHKSKvGSASGFIHLIGSVSGIIGPIATGFIVQNTGhFDSAFILAGGVAALGAILVF 412
Cdd:cd17324 311 RVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
22-413 |
1.92e-18 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 86.59 E-value: 1.92e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 22 LDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLI 101
Cdd:cd17371 13 FDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 102 LRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVA----GPIVGYLAISFGWRPAFMiiasIGIVWML 177
Cdd:cd17371 93 LRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLAtllaALLFPLLPPEIAWRVLFL----LGALPAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 178 VWFFTAADNPEkSHRVTEHERqwvnRLKTEKINDEEDLTQSAQTLGYYLRqpIILVTAFAFFCYnyilFFFLSWFPAYLV 257
Cdd:cd17371 169 LVLFIRRFVKE-PPQWQAARA----ARRHFADRPSLRELFSPPLLRTTLL--ASLLATGALGGY----YGITTWLPSYLT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 258 QAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltGRlllsRKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSVS 337
Cdd:cd17371 238 GERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI----GR----RNNFALFALGSAISILLYFFLPLSPTLILILGFPL 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516061811 338 IFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVAALGAILVFF 413
Cdd:cd17371 310 GFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
57-414 |
5.67e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 84.93 E-value: 5.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 57 AIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGL 136
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 137 LSAGSPLGGAVAGPIVGYLAiSFGWRPAFMIIASIGIVWMLVWFFTaadnPEKSHRVTEHERQWVNRLKTEKIndeedlt 216
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLFL----PEPARKSKSAASPGAATAAALPW------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 217 qsaqtlgyyLRQPIILVTAFAFFCYNYILFFFLswfPAYLVQAHGLNikemslTTVIPWIVGFFGLAlgGIISDKIFNLT 296
Cdd:cd17473 197 ---------KRVLPIYFLAFLAMLLFYVIPIQL---PFLLQERGGGS------AALIGLALAIASLA--GAIGALLFGRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 297 GRLLLSRKIVLVVSLLAAA--ICVALAGVVTRVVPAVMLMSVSIFFLYTTGAiywAIIQDVVHKSKVGSASGFIHLIGSV 374
Cdd:cd17473 257 KRRLGKRRLLAIGFALMALgfLLLALASGLWVVLLGAILAGLGFGLLLPTLN---SWAMSLVPPELRGRAMGIVTSAFFL 333
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 516061811 375 SGIIGPIATGFIVQNTGHFDSAFILAGGVAALGAILVFFV 414
Cdd:cd17473 334 GQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
7-414 |
6.41e-18 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 85.02 E-value: 6.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 7 WIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIF 86
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 87 CGMTAIAT---GFYSMLILRVLFGMAEGPicASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRP 163
Cdd:cd17355 82 LVLLALATslwQLYLLWGLLGGGGAGTLA--AVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 164 AFMIIASIGIVWML-VWFFTAADNPEKSHRVTeherqwvnrlktekinDEEDLTQSAQTLGYYLRQPIILVTAFAFFCYN 242
Cdd:cd17355 160 ALLVLALLALLVLVpVLLLLRRRPADLALRAY----------------DDASPASPGSTLKEALRSASFWLLALAFFLCG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 243 YILFFFLSWFPAYLVQaHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAG 322
Cdd:cd17355 224 FAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRY---------SPRRLLAASYALRALGLALLL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 323 VVTRVVPAVMLMSVSIFFLY-TTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAG 401
Cdd:cd17355 294 LLPFPPLALLLFAALFGLGWgATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAV 373
|
410
....*....|...
gi 516061811 402 GVAALGAILVFFV 414
Cdd:cd17355 374 ALGLIAALLVLPI 386
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
6-410 |
4.26e-17 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 82.07 E-value: 4.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGL---AVGL 82
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIgliATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 83 WSIFCGMTAIATGFYSMLILRVLFGMAEGPICAsanKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWR 162
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCA---RLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 163 PAFMIIASIGIVWMLVWFFTAADNPekshrvteherqwvnrlktekindeedltqsaqtlgyylrqPIILVTAFAFFCYN 242
Cdd:cd17488 158 AGMYVPGIIAILMGIVLCWRLRDRP-----------------------------------------PYIWLLAFCYVLVY 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 243 YILFFFLSWFPAYLVQAHGLNIkeMSLTTVIPW--IVGFFGLALGGIISDKIFNlTGRLLLSrkIVLVVSLLAAAICVAL 320
Cdd:cd17488 197 VVRTAINDWGNLYLSETHGYSL--VKANSAVSLfeVGGLIGALVAGWGSDKLFK-GNRGPMN--LIFALGLLVSVGALWL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 321 AGVVTRVVPAVMLMSVSiFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIG--PIAtgfIVQNTGHFDSAFI 398
Cdd:cd17488 272 VPVHSYWLLATCFFTIG-FFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAgyPLA---KVIESWGWSGFFI 347
|
410
....*....|..
gi 516061811 399 LAGGVAALGAIL 410
Cdd:cd17488 348 VISIAAAISGLL 359
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
6-289 |
9.26e-17 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 80.24 E-value: 9.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSI 85
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAF 165
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 166 MIIASIGIVWMLVWFFTAADNPEKSHRVTEHERQWVNRLKTEKINDEEDLTQSAQTLGYYLRQPIILVTAFAFFCYNYIL 245
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 516061811 246 FFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIIS 289
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-412 |
1.33e-16 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 80.68 E-value: 1.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 27 LSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLF 106
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 107 GMAEGPICASANKMINGwFPKKQAATAMGLLSAGSPLGGAVaGPIVGYLAISFGWRPAFMIIASIGIVWMLVWFFTAadN 186
Cdd:cd17478 95 GIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFAL-GPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL--R 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 187 PEKSHRVTEHERQWVNRLKTEKIndeedltqsaqtlgyylRQPIILVTAFAFFCYnYILFFFLSWFPAYLVQaHGLNIKE 266
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGV-----------------WRALLLLLIIVFLRS-WVLSSLTTFLPFYLVQ-RGYSLVF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 267 MSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAgVVTRVVPAVMLMSVSIFFLYTTGA 346
Cdd:cd17478 232 AGLLLSLFLFAGAIGTLIGGPLSDRF---------GRRRVIIASLLLAAPFLLLF-LLTPGIWSYILLVLAGFLLFASFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516061811 347 IYWAIIQDVVHKSkVGSASGFIHLIGSVSGIIGPIATGFIVQNTGhFDSAFILAGGVAALGAILVF 412
Cdd:cd17478 302 VTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFG-LESVLLILALLPLLGALLAF 365
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
10-423 |
6.82e-15 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 75.77 E-value: 6.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 10 VLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGM 89
Cdd:PRK11551 17 IGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 90 TAIATGFYSMLILRVLFGMAEG-------PICASAnkmingwFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWR 162
Cdd:PRK11551 97 TAQAWDFPSLLVARLLTGVGLGgalpnliALTSEA-------VGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 163 PAFMI--IASIGIVWMLVWFFtaadnPEKSHRVTEHERQWVNRLKTEKINDEEdltQSAQTLGYYLrqpiilvtafAFFC 240
Cdd:PRK11551 170 HIFYVggVGPLLLVPLLMRWL-----PESRAFAQAAGAGKQRAPVLRALFGEG---RATATLLLWI----------SYFF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 241 YNYILFFFLSWFPAYLVqAHGLNIKEMSLTTvipwivgfFGLALGGIISDKifnLTGRLLLSRKIVLVVSLLAAAICVAL 320
Cdd:PRK11551 232 TLIVLYFLLNWLPSLLV-GQGLSRSQAGLVQ--------IAFNIGGALGSL---LIGALMDRLRPRRVVLLIYAGILASL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 321 AGVVTrvVPAVMLMSVSIFF-----------LYTTGAIYWAIiqdVVHKSKVGSASGfihlIGSVSGIIGPIATGFIVQn 389
Cdd:PRK11551 300 AALAA--APSFAGMLLAGFAaglfvvggqsvLYALAPLFYPT---QVRGTGVGAAVA----VGRLGSMAGPLLAGQLLA- 369
|
410 420 430
....*....|....*....|....*....|....*
gi 516061811 390 TGHFDSAFILAGG-VAALGAILVFFVIKPPKHQPQ 423
Cdd:PRK11551 370 LGRSTVGVIGASIpVILVAALAALLLVSRPSRADP 404
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
13-415 |
1.63e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 71.44 E-value: 1.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 13 LCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFG--PTLVMGLAV-GLWSIFCgm 89
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGrkRVFLIGLALfGLASLLC-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 90 tAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIA 169
Cdd:cd17321 79 -ALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 170 SIGIVwmlVWFFTaadnpekshrvteherqwvnrlktekindeedltqsaqtlgyylrqPIILVTAFAFFCYNYILFFFL 249
Cdd:cd17321 158 PIGLV---ALLLA----------------------------------------------RTFSGAVLAAFLLGAALGGLL 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 250 SWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFnltgrlllSRKIVLVVSLLAAAICVALAGVVTRVVP 329
Cdd:cd17321 189 FLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFG--------PRLVLVAGLLLTAVGLLLLALLGADSSV 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 330 AVMLMSVSIFFLYTtgAIYWAIIQDV----VHKSKVGSASG---FIHLIGSVSG--IIGPIATGFIVQNTGH-------- 392
Cdd:cd17321 261 WLLLPGLVLLGLGL--GLFATPLTNAalssVPKEKAGAASGilnTARQLGGALGvaLLGALLTAGLSANLGDsgvaalls 338
|
410 420 430
....*....|....*....|....*....|..
gi 516061811 393 ---------FDSAFILAGGVAALGAILVFFVI 415
Cdd:cd17321 339 aaaaafaagFHLAFLVAAALALLAALLALLLP 370
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
2-411 |
1.74e-13 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 71.67 E-value: 1.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 2 FKNLRWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGL--- 78
Cdd:PRK11663 17 YRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIgli 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 79 AVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICAsanKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAIS 158
Cdd:PRK11663 97 ATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCA---KLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALH 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 159 FGWRPAFMIIASIGIVWMLVWFFTAADNPEKSHrvTEHERQWVN-RLKTEKINDEEDLTQSAQTLGYYLRQPIILVTAFA 237
Cdd:PRK11663 174 YGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMG--LPSVGEWRHdALELAQQQEGAGLSRKEILTKYVLLNPYIWLLSFS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 238 FFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNlTGR----LLLSRKIVLVVSLLa 313
Cdd:PRK11663 252 YVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFN-GNRgpmnLIFAAGILLSVGSL- 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 314 aaicvALAGVVTRVVPAVMLMSVSiFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIG----SVSGIigPIAtgfIVQN 389
Cdd:PRK11663 330 -----WLMPFASYVMQAACFFTIG-FFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAylgaALSGY--PLA---KVLE 398
|
410 420
....*....|....*....|..
gi 516061811 390 TGHFDSAFILAGGVAALGAILV 411
Cdd:PRK11663 399 IWHWTGFFVVISIAAGISALLL 420
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
15-413 |
3.87e-13 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 70.36 E-value: 3.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 15 LVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIAT 94
Cdd:cd17341 6 LSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 95 GFYSMLI-LRVLFGMAeGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVA---GPIV----GYLAISFGWRPAFm 166
Cdd:cd17341 86 SSYWGLLvLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSqllAPLIagaiVFDGGFVGWRNAF- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 167 IIASIGIVWMLVWFFTAADNPEKSHRVTEHER-QWVNRLKTEKIndeedltqsaqtlgyylrqpiilvtafAFFCYNYIL 245
Cdd:cd17341 164 FVPGILLAIAAVLVLLFGDDLPTGKASALEFLkVQLAVLKNYRT---------------------------WILSLLYGV 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 246 FF-----FLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKiFNLTGRLLlsrkIVLVVSLLAAAICVAL 320
Cdd:cd17341 217 TFgsfvgFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDR-FGGRRRLW----WLFIVMTIGAALLSLS 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 321 AGVVTRVVPAVMLMSVSIFFlyTTGAIYWAIIQDV--VHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFI 398
Cdd:cd17341 292 LPTSGTNLVLFLALFVALGL--GAGAGNGSVFRMVpfIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFS 369
|
410
....*....|....*
gi 516061811 399 LAGGVAALGAILVFF 413
Cdd:cd17341 370 LFGVLAVACTLLVWL 384
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
25-183 |
5.50e-13 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 70.06 E-value: 5.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 25 VALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIAT--GFYSMLIL 102
Cdd:cd17382 31 DAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAArvHYGCVIFV 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 103 RVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIVWMLVWFFT 182
Cdd:cd17382 111 RILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV 190
|
.
gi 516061811 183 A 183
Cdd:cd17382 191 S 191
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
46-415 |
2.04e-12 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 68.06 E-value: 2.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 46 GMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICASaNKMINGWF 125
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNA-TALIASQT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 126 PKKQAATAMGLLSAGSpLGGAVAGPIVG-YLAISFGWRPAFMIIASI-GIVWMLVWFFTAadnpEKSHRVTEHERqwvnr 203
Cdd:cd17391 118 PKEKSGWALGTLSTGV-VAGTLIGPLLGgFLADLFGIRNVFFITGGLlFLAFLLTLFFVK----EDFKPVEKKKM----- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 204 lktekindeedlTQSAQTLGYYLRQPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLA 283
Cdd:cd17391 188 ------------VSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVSSLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 284 LG---GIISDKIFNltgrlllsRKIVLVVSLLAAAICVALAGVVTrvvpAVMLMSVSIFFLYTTGAIYWAI---IQDVVH 357
Cdd:cd17391 256 SAprlGKLGDRIGH--------HRILLGALLASALLYIPQAFVQT----PWQLGILRFLLGLATGGLLPAInslLAKITP 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 358 KSKVGSASGFIHLIGSVSGIIGPIATGFIvqnTGHFD--SAFILAGGVAALGAILVFFVI 415
Cdd:cd17391 324 KEVAGRIFGYNQSFQYLGNVAGPLLGSAI---AAHFGyrAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
10-181 |
4.51e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.22 E-value: 4.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 10 VLLLCLVYMINYLDRVALSITVPM-IEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCG 88
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 89 MTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMII 168
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
170
....*....|...
gi 516061811 169 ASIGIVWMLVWFF 181
Cdd:cd17325 361 AALLLLAAVLFLL 373
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
32-415 |
1.11e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 66.06 E-value: 1.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 32 PMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFG--PTLVMGLAV-GLWSIFCgmtAIATGFYSMLILRVLFGM 108
Cdd:cd17320 23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGrrPVLLAGLLLfILASLLC---ALASSIEQLLIARFLQGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 109 AEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIV-WMLVWFFTaadnP 187
Cdd:cd17320 100 GAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLlLLLVLLFL----P 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 188 EKSHRVTEHERQWvnrlktekindeedltQSAQTLGYYLRQPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEM 267
Cdd:cd17320 176 ETLPEEKRKPLLS----------------SLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 268 SLTTVIPwivgFFGLALGGIISDKIFNLTGrlllSRKIVLVVSLLAAAICVALAGVVTR-------VVPAVMLMSVSIFF 340
Cdd:cd17320 240 GLLFALN----AIALILGSLLNGRLVRRFG----PRRLLRLGLLLLLAAALVLLLAALLgglslwpLVAPLFLIFFGFGL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516061811 341 LYTTgAIYWAIiqdVVHKSKVGSASGfihLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVAALGAILVFFVI 415
Cdd:cd17320 312 IFPN-ATSLAL---EPFPHVAGTASA---LLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-413 |
1.50e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 65.31 E-value: 1.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 15 LVYMINYLdrvaLSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIAT 94
Cdd:cd17489 7 FFFLSFYL----LLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 95 GFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIV 174
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 175 WMLVWFFTAADNPEKSHRVTEHERQWVNRLKTEKIndeedltqsaqtlgyylrqPIILVTAFAFFCYNYILFFflswFPA 254
Cdd:cd17489 163 ALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVL-------------------PPALILFLASIAYGAISTF----LPL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 255 YLVQahgLNIKEMSLTTVIPWIVGFFGLALGGIISDKifnltgrllLSRKIVLVVSLLAAAICVALAGVVTrvvPAVMLM 334
Cdd:cd17489 220 YAAE---RGISNAGLFFTVYAIALLLSRPFSGKLSDR---------KGPKTVIIPGLLLLALGLLLLSFAG---SPWMLL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 335 SVSIFFLYTTGAIYWAI---IQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGhFDSAFILAGGVAALGAILV 411
Cdd:cd17489 285 LAAVLYGLGFGLLFPALqalAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLY 363
|
..
gi 516061811 412 FF 413
Cdd:cd17489 364 IF 365
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
28-376 |
3.79e-11 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 64.25 E-value: 3.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 28 SITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYS-MLILRVLF 106
Cdd:TIGR00886 22 PLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYSvLLLIRLFI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 107 GMAeGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISF----------GWRPAFMI-IASIGIVW 175
Cdd:TIGR00886 102 GIA-GGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLifgggqpahlAWGWAFVIvPAGILLLP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 176 MLVWFFTAADNPekshrvteherqwVNRLKTEKINDEEDLtqsaqtlgyylrqPIILVTAFAFFCYNYILFF-----FLS 250
Cdd:TIGR00886 181 ALLIFFVGADTP-------------PGKPATGKLSFKEAL-------------KVFGNRHTWILALLYSVTFgsflgVSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 251 WFPAYLVQAHGLN-IKEMSLTTVIPWIvGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAGVVTRVVP 329
Cdd:TIGR00886 235 IFAMLFKDQFGLSkVQAGAYASLGGFL-GSLARPAGGAISDRL---------GGARKLLMNFLGVAMGAFLVVLGLVSDG 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 516061811 330 AVMLMSVSIFFLYTT-----GAIYWAIiqDVVHKSKVGSASGFIHLIGSVSG 376
Cdd:TIGR00886 305 SLAAFIVLFVALFFFagagnGSTFALV--PHIFRRATGAVSGLIGAIGNLGG 354
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
27-414 |
7.83e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 63.37 E-value: 7.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 27 LSITVPMIEKELTINPEQFGMIFGSFFFGYAIFN-FLGGLAvDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVL 105
Cdd:cd17504 15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTpILGRLG-DLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 106 --FGMAEGPICASankMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIVwmlvwffTA 183
Cdd:cd17504 94 qgIGGAVFPLAFA---LVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL-------LA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 184 ADNPEKSHRvteherqwvnrlktekindeedltqsaqtlgyYLRQPIILVTAFAFFCYNYILFFFLSWFPAYLVQAH--- 260
Cdd:cd17504 164 ALVPLIDLR--------------------------------LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptg 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 261 -GLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrllLSRKIVLVVSLLAAAICVALAGVVTRVVP---AVMLMSV 336
Cdd:cd17504 212 fGLGITEAGLLLLPGALVMLIAGPLAGRLIARV--------GPRRVLLIGLVISAVGLLLLALLHSSLWAlvvALLLIGI 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 337 SIFFLYTTGAIywaIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQN------------TGHFDSAFILAGGVA 404
Cdd:cd17504 284 GLGLAFASLPN---IVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTytvsitsggvptEGAYVLAFLIGAALA 360
|
410
....*....|
gi 516061811 405 ALGAILVFFV 414
Cdd:cd17504 361 LAALLLSLLI 370
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
46-209 |
3.02e-10 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 61.47 E-value: 3.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 46 GMIFG-SFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLwSIFCGMTAIATGFYSMLILRVLFGMAEGPIcASANKMINGW 124
Cdd:PRK09874 57 GLVFSiTFLFSAIASPFWGGLADRKGRKIMLLRSALGM-GIVMVLMGLAQNIWQFLILRALLGLLGGFV-PNANALIATQ 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 125 FPKKQAATAMGLLSAGSpLGGAVAGPIVG-YLAISFGWRPAFMIIASIGIVWMLVWFFTAADNPEK-SHRVTEHERQWVN 202
Cdd:PRK09874 135 VPRNKSGWALGTLSTGG-VSGALLGPLAGgLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPvSKKEMLHMREVVT 213
|
....*..
gi 516061811 203 RLKTEKI 209
Cdd:PRK09874 214 SLKNPKL 220
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-188 |
5.42e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 60.65 E-value: 5.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 7 WIIVLLLCLVYMINYldrVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFG--PTLVMGLAVGLWS 84
Cdd:COG2271 183 WLLALAYFLVYFALY---GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 85 IFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPA 164
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|....
gi 516061811 165 FMIIASIGIVWMLVWFFTAADNPE 188
Cdd:COG2271 340 FLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
46-411 |
8.64e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 59.88 E-value: 8.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 46 GMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWF 125
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 126 PKKQAATAMGLLSAGSPLGGAVaGPIVGYLAISFGWRPaFMIIASIGIVWMLVWFFTAADNPEKSHRVTEHERQwvnrlk 205
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGFAL-GPLLLALVGTAGALP-FLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRR------ 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 206 tekindeedltqsaqtlgYYLRQPIILVTAFAffcYNYILFFFLSWFPAYLVQaHGLNIKEMSLTTVIPWIVGFFGLALG 285
Cdd:cd17477 186 ------------------LLRIAPLALLGAFV---AGFLEGAFYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWPL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 286 GIISDKifnltgrllLSRKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSV----SIFFLYTTGAiywAIIQDVVHKSKV 361
Cdd:cd17477 244 GWLADR---------FDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFlwggAAGPLYTLAL---ALAGDRLPGDEL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 516061811 362 GSASGFIHLIGSVSGIIGPIATGFIVQNTGHfDSAFILAGGVAALGAILV 411
Cdd:cd17477 312 VAANAALLLLYGLGSVIGPLLAGALMDAFGP-HGLFLFLAAVALLFLLFL 360
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
22-174 |
1.82e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 59.13 E-value: 1.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 22 LDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLI 101
Cdd:cd17503 10 LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLII 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516061811 102 LRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIV 174
Cdd:cd17503 90 FRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGIL 162
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
15-415 |
1.95e-09 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 59.17 E-value: 1.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 15 LVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIAT 94
Cdd:PRK12307 25 LGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLAS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 95 GFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMiiasIGIV 174
Cdd:PRK12307 105 GVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFF----VGLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 175 WMLVWFFTAADNPEkshrvtehERQWV-NRLKTEKINDEEDLTQSAQTLGYYLRQP------IILVTAFAFFCYNYILFF 247
Cdd:PRK12307 181 PVLLVIYIRARAPE--------SKEWEeAKLSGKGKHSQSAWSVFSLSMKGLFNRAqfpltlCVFIVLFSIFGANWPIFG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 248 FLswfPAYLVqAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAGVVTrv 327
Cdd:PRK12307 253 LL---PTYLA-GEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRI---------GLKKTFSIGLLMSFLFIFPLFRIP-- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 328 VPAVMLMSVSIFFLYTT----GAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGV 403
Cdd:PRK12307 318 QDNYLLLGACLFGLMATnvgvGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGLGAALTFIVAFW 397
|
410
....*....|..
gi 516061811 404 AALGAILVFFVI 415
Cdd:PRK12307 398 TATILLIIGLSI 409
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
234-424 |
2.86e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.20 E-value: 2.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 234 TAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLA 313
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---------GRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 314 AAICVALAGVVTRVVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGhF 393
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-W 150
|
170 180 190
....*....|....*....|....*....|.
gi 516061811 394 DSAFILAGGVAALGAILVFFVIKPPKHQPQT 424
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESKRPK 181
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
46-181 |
3.11e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 54.96 E-value: 3.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 46 GMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWF 125
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 516061811 126 PKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIVWMLVWFF 181
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAF 136
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
17-413 |
9.83e-09 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 57.01 E-value: 9.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 17 YMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFfgyaIFNFLGGLAV----DKFGPTLVMGLAVGLWSIFCGMTAI 92
Cdd:PRK03893 29 YLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAF----ISRWFGGLLLgamgDRYGRRLAMVISIVLFSVGTLACGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 93 ATGFYSMLILRVLFGMA-EGPICASANKMINGWfPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMI-IAS 170
Cdd:PRK03893 105 APGYWTLFIARLVIGMGmAGEYGSSATYVIESW-PKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIgILP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 171 IGIVWMLVWFFTAADNPEKSHRVTEHERQWVNRLKTEK---INDEEDLTQSAQTLGYYLRQ--------PIILVTAFAFF 239
Cdd:PRK03893 184 IIFALWLRKNLPEAEDWKEKHAGKAPVRTMVDILYRGEhriINILLTLAAAAALWFCFAGNlqnaaivaVLGLLCAAIFI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 240 CYNY----------------ILFFFL-SW-----FPAYLVQahGLNIKEMSLTTVIPWivGFFGLALGGIISdkifNLTG 297
Cdd:PRK03893 264 SFMVqssgkrwptgvmlmvvVLFAFLySWpiqalLPTYLKT--DLGYDPHTVANVLFF--SGFGAAVGCCVG----GFLG 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 298 RLLLSRKiVLVVSLLAAAICVALAGVVTRvvPAVMLMSVSIFFLYTTG----AIYWAIIQDVVHKSKVGSASGFIHLIGS 373
Cdd:PRK03893 336 DWLGTRK-AYVCSLLISQLLIIPVFAIGG--ANVWVLGLLLFFQQMLGqgisGLLPKLIGGYFDTEQRAAGLGFTYNVGA 412
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 516061811 374 VSGIIGPIATGFIVQNTGHFDSAFILAGGVAALGAILVFF 413
Cdd:PRK03893 413 LGGALAPILGALIAQRLDLGTALASLSFSLTFVVILLIGL 452
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
6-181 |
1.40e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.47 E-value: 1.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSI 85
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAF 165
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*.
gi 516061811 166 MIIASIGIVWMLVWFF 181
Cdd:cd06173 367 LLAGALLLLAALLLLL 382
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
6-414 |
1.94e-08 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 55.88 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMglAVGLWSI 85
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLM--ALAGIMV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIATGFYSMLILRVLF---GMAEGPICASANKMINGWFPKKQAaTAMGLLSAGSPLGGAVAGPIVGYLAISFGWR 162
Cdd:cd17314 79 LAGYTYLSYVFNSFPLSYACFvfiGAGTGILYGSAVLVTTQYFPDTKG-LALGLPTTGYSLGLVLGSPLLRILWVFYGLA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 163 PAFMIIasiGIVWMLVWFFTAADNPEKSHRVTEheRQWVNRLKTekindeedltqsaQTLGYYLRQPIILVTAFAFFcyn 242
Cdd:cd17314 158 LVYTIL---GILAAIVLSVVSLLGFKEPPDNQA--RLHVQKKKT-------------QTMGEIFRDKVFWILFIAIF--- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 243 yilFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLA------LGGIISDKifnltgrlLLSRKIVLVVSLLAAAI 316
Cdd:cd17314 217 ---LVLIGGFLFIANMASLVRSLQLDAPSFVTKLMSIYGLFnafgrlLWGIVADF--------FGGRLSTLSILLTILGL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 317 CVALAGVVTRVVPAVMLMSVSIFFLYTTG--AIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFD 394
Cdd:cd17314 286 GLCAFLFLLKMTPVGLVLTGSLLGFSYGGlfTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYI 365
|
410 420
....*....|....*....|
gi 516061811 395 SAFILAGGVAALGAILVFFV 414
Cdd:cd17314 366 SAVYIYAVIVFLASAILLAV 385
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
13-414 |
3.82e-08 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 54.92 E-value: 3.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 13 LCLVYMINYLDRVALSI---TVPMIEKELTINPEQFGMiFGSFFfgyAIFNFLGGLAV----DKFGPTLVMGLAVGLWSI 85
Cdd:cd17331 2 LLIVHLNIVLYATCYWLqqpVLPYLTKKLGVDSVVFGY-LQTTF---SVLQLVGGPLFgrfgDLFGPRAALVLSFLSSAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 86 FCGMTAIATGFYSMLILRV-LFGMAeGPICASAnkMINGWFPKKQAATAMGLLSAgSPLGGAVAGPIVG-YLAISFGWRP 163
Cdd:cd17331 78 SYLLLAFASSVPMLFLSRLpSVFMH-AMQAAQM--VVTDLTDPGERAAALGRLGL-SYGIGMVVGSFLGgLLTKKFGEQA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 164 AfMIIASIG--IVWMLVWFFTaadnPEKSHRVTEHERqwvnrlktekinDEEDLTQSAQTLGYYLRQPIILVTAFAFFCY 241
Cdd:cd17331 154 A-ALVAAVGslLSIVLVILLI----PSNTKSKREKEA------------KESASPPSVFNLKEILRLLRLPGVAFLLLVK 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 242 NYILF---FFLSWFPAYLVQAHGLNIKEMSLTTVIpwiVGFFGLALGGIisdkifnLTGRL--LLSRKIVLVVSLLAAAI 316
Cdd:cd17331 217 LLSGLpigMFQSMFSLVAMDFFGLTPEENGYLMSY---AGVLGMVVQGL-------LVGPLtkRFGERSLLKLSVALLAI 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 317 CVALAGVVTRVVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHfdSA 396
Cdd:cd17331 287 GYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGF--PS 364
|
410
....*....|....*...
gi 516061811 397 FILAGGVAALGAILVFFV 414
Cdd:cd17331 365 FGLLGAAINGLLTVYLLL 382
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
130-416 |
4.85e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.91 E-value: 4.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 130 AATAMGLLSAGSPLGGAVAGPIVGYLA--ISFGWRPAFMIIASIGIVWMLVWFFTAadnpekshrvteherqwvnrlkTE 207
Cdd:COG2211 149 SSWRFAFAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLAFLLTFFGT----------------------KE 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 208 KINDEEDLTQSAQTLGYYLRQPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGI 287
Cdd:COG2211 207 RPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPR 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 288 ISDKIfnltgrlllSRKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSVSIFFLYTTG--AIYWAIIQDVV-------HK 358
Cdd:COG2211 287 LAKRF---------GKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAilVLPWAMLADVVdydewktGR 357
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516061811 359 SKVGSASGFIHLIGSVSGIIGPIATGFIVQNTG-------------HFDSAFILAGGVAALGAILVFFVIK 416
Cdd:COG2211 358 RREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsaltGIRLLFFLLPAVLLLLAALLLLFYP 428
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
24-413 |
4.88e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.54 E-value: 4.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 24 RVALSITVpmieKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMgLAVGLWSIFCGMTAIATGFYSMLILR 103
Cdd:cd06173 19 TVALPWLV----LQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLL-ILADLLRALLAAVLALLALLGSLSLW 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 104 VLFGMAEGPICASA------NKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIA-SIGIVWM 176
Cdd:cd06173 94 LLLVLAFLLGIASAffgparQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINAlSFLLSAL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 177 LVWFFTAADNPEKSHRVTEHERQWVNRLKtekindeedltqsaqtlgYYLRQPIILVTAFAFFCYNYILFFFLSWFPAYL 256
Cdd:cd06173 174 LLLFIRRPPPAAPGESSSLLLRDLREGLR------------------YLRRSPLLRLLLLALALFALLGGALTVLLPLLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 257 VQAHGLNIKEMSLTTVIPWIvgffGLALGGIISDKIFNLTGRLLLsrkivLVVSLLAAAICVALAGVVTRVVPAVMLMSV 336
Cdd:cd06173 236 KEVLGGGAAGYGLLLAAFGV----GALLGALLLGRLSKRRRRGRL-----LLIGALLLGLALLVLGLSPSLWLLLAALFL 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516061811 337 SIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFdSAFILAGGVAALGAILVFF 413
Cdd:cd06173 307 LGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS-AVFLLAGALLLLAALLLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
227-429 |
5.73e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.21 E-value: 5.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 227 RQPIILVTAFAFFCYNYILFFFLSWFPAyLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIV 306
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF---------GRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 307 LVVSLLAAAICVALAGVVTRVVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFI 386
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 516061811 387 VQNTGhFDSAFILAGGVAALGAILVFFVIKPPKHQPQTRISHS 429
Cdd:COG2814 158 ADLFG-WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS 199
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
33-198 |
6.76e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 54.13 E-value: 6.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 33 MIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFG--PTLVMGLavGLWSIFCGMTAIATGFYSMLILRvlFGMAE 110
Cdd:PRK11043 31 AIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGrkPVLLAGL--SLFALGSLGMLWVESAAQLLVLR--FVQAV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 111 GpICASA---NKMINGWFPKKQA----ATAMGLLsAGSPlggAVAgPIVG-YLAISFGWRPAFMIIASIGIVWMLvwfFT 182
Cdd:PRK11043 107 G-VCSAAviwQALVIDRYPAQKAnrvfATIMPLV-ALSP---ALA-PLLGaWLLNHFGWQAIFATLFAITLLLIL---PT 177
|
170
....*....|....*.
gi 516061811 183 AADNPEKSHRVTEHER 198
Cdd:PRK11043 178 LRLKPSKKARKQSQDA 193
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
16-413 |
2.17e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.58 E-value: 2.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 16 VYMINYLDRVALSITVPMI------EKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGM 89
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLpfyvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 90 TAIATGFYSMLILRVLFGMAEGPICAsANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIA 169
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 170 SIGIV-WMLVWFFTaadnpekshrvteherqwvnrlktekindeedltqsaqtlgyylrqPIILVTAFAFFCYNYILFFF 248
Cdd:cd17330 160 ALALLnLVLVLFFL----------------------------------------------PPLRRLLLVYFLIALAFAGL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 249 LSWFPAYLVQAHGLNIKEMSLTTVIpwiVGFFGLALGGIISDKIfnltgRLLLSRKIVLVVSLLAAAICVALAGVVTRVV 328
Cdd:cd17330 194 ESVFSLFLKDRFGFSPSQIGLLLAL---VGIAGILAQLLLIPRL-----AKRLGERKLLRLGLLLAIIGLLLLPFASSVP 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 329 PAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFdSAFILAGGVAALGA 408
Cdd:cd17330 266 LLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPG-VPFLLAAGLLLIAL 344
|
....*
gi 516061811 409 ILVFF 413
Cdd:cd17330 345 FLLSL 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
231-425 |
2.63e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.19 E-value: 2.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 231 ILVTAFAFFCYNYILFFFLSwfpaYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVS 310
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILP----LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRF---------GRKRLLLLG 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 311 LLAAAICVALAGVVTRVVpavmLMSVSIFFLYTTGAIYW----AIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFI 386
Cdd:cd17325 68 LLLLAVSTLLFAFATSYW----QLLLARFLQGLASAAVWpaamALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLL 143
|
170 180 190
....*....|....*....|....*....|....*....
gi 516061811 387 VQNTGhFDSAFILAGGVAALGAILVFFVIKPPKHQPQTR 425
Cdd:cd17325 144 ADALG-YRAPFLVCAALALLALVLALLLLPEPRPPPNKR 181
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-148 |
2.88e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.28 E-value: 2.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 1 MFKNLRWIIVLLLCLVYMINYLdrVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAV 80
Cdd:COG2814 203 LLRRPRLLLLLLLAFLLGFGFF--ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516061811 81 GLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVA 148
Cdd:COG2814 281 LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
19-416 |
3.38e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.84 E-value: 3.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 19 INYLDRVALSITVPMI----EKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIAT 94
Cdd:cd17329 7 GSFLNRLGFFMVWPFMaiylHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 95 GFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVaGPIVGYLAISFGWRPAFMIIASIGIV 174
Cdd:cd17329 87 SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAI-GPLLGGLLLLYSFRLLFLAAAVLFLL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 175 WMLVWFFTAADNPEKSHRVTEHERQWVNRLKtekindeedltqsaqtlgyyLRQPIILVTAFAFFCYNYILFFFLSWFPA 254
Cdd:cd17329 166 AALVLLFLLPETRPKRRAAEKTEILRGYKIV--------------------LRDRAFLLFLLASFLISLIYFQLESTLPV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 255 YLVQAHGLNikemslttviPWIVGFFgLALGGIIsdkIFNLTGRLL-LSRKIVLVVSLLAAAICVALAGVVTRVVPAVML 333
Cdd:cd17329 226 YVVEILGLG----------ESLLGLL-LALNALL---IVLLQFPVArLVERFRLRKILMIGILLFAIGFAVLAFANTLAV 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 334 MSVSIFFLYTTGAIYWAIIQDVVH----KSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGhfdsAFILAGGVAALGAI 409
Cdd:cd17329 292 LILAMIVLTLGEMLVFPAVQTLVAalapPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG----PGLPWLILAALGLI 367
|
....*..
gi 516061811 410 LVFFVIK 416
Cdd:cd17329 368 AAALLLG 374
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
31-293 |
4.33e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 51.81 E-value: 4.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 31 VPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAE 110
Cdd:cd17323 22 LPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 111 GPICASANKMINGWFPKKQAATAMGLLSAGsPLGGAVAGPIVG-YLAISFGWRPAF---MIIASIGIVWMLVWFftaadn 186
Cdd:cd17323 102 SSPLAIGAGTIADLFTPEERGKAMGVYSLG-PLLGPALGPIIGgFITQSLGWRWIFwflAIISGFCLILIFLFL------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 187 pekshrvteherqwvnrlktekindeedltqsaqtlgyylrqPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKE 266
Cdd:cd17323 175 ------------------------------------------PIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGE 212
|
250 260
....*....|....*....|....*..
gi 516061811 267 MSLTTVIPWIVGFFGLALGGIISDKIF 293
Cdd:cd17323 213 VGLMYLPIGIGALIGSIIGGRLSDYYY 239
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
51-341 |
4.36e-07 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 51.55 E-value: 4.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 51 SFFFGYAIFNFLGGLAVDKFGPTLVmgLAVGLWS----IFC-GMTAIATGFYS---MLILRVLFGMAEGPICASANKMIN 122
Cdd:cd17342 71 IFLFSYAIGLFISGWLGDRLNLRLV--LAFGMCSsaitVFLfGVLTEWLHFYNkylYCILWVLNGLLQSTGWPCVVAIMG 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 123 GWFPKKQAATAMGLLSAGSPLGGaVAGPIVGYLAISFGWRPAFMIIASIGIVWMLVWFFTAADNPekshrvteherqwvn 202
Cdd:cd17342 149 NWFGKSSRGFVLGLWSACASVGN-IIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP--------------- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 203 rlktekindeedltqsaqtlgyylrqPIILVTAFAFFCY---NYILFFflsWFPAYLvqAHGLNIKEMSLTTVIPW--IV 277
Cdd:cd17342 213 --------------------------PGVIPYSLAYACLklvNYSFFF---WLPFYL--SNNFHWKESEADQLSIWydVG 261
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516061811 278 GFFGLALGGIISDkifnltgrLLLSRKIVLVVSLLAAAIC-VALAGVVTRVVPAVMLMSVSIFFL 341
Cdd:cd17342 262 GIIGGIVAGYISD--------RMGSRSPVVVVMLLLAIPSlFVYSHSPSDKVLNAFVMTITGFFI 318
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
5-174 |
5.77e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.06 E-value: 5.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 5 LRWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWS 84
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 85 IFCGMTAIA--TGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWR 162
Cdd:cd17316 255 ILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGT 334
|
170
....*....|..
gi 516061811 163 PAFMIIASIGIV 174
Cdd:cd17316 335 GVPALILALLAI 346
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
5-192 |
1.34e-06 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 50.46 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 5 LRWIIVLLLCLVYMInyLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPT---LVMGLAVG 81
Cdd:TIGR00711 1 LLLTIVLMLGTFMAV--LDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRrlfLISTFAFT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 82 LWSIFCGmtaIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVaGPIV-GYLAISFG 160
Cdd:TIGR00711 79 LGSLLCG---VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPAL-GPTLgGWIIENYH 154
|
170 180 190
....*....|....*....|....*....|..
gi 516061811 161 WRPAFMIIASIGIVWMLVWFFTAADNPEKSHR 192
Cdd:TIGR00711 155 WRWIFLINVPIGIIVVVVAFFILPRDKPAASE 186
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
24-414 |
4.40e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 48.45 E-value: 4.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 24 RVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILR 103
Cdd:cd06180 15 RFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 104 VLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIV-GYLAISFGWRPAFMIIASIGIVWMLVWFFT 182
Cdd:cd06180 95 FLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVpAGLGGGLSWRAGWLALALLSAVLLLLSFLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 183 AADNPEKSHRVTEHERQWVNRLKTEKIndeedltqsaqTLGYYLrqpiilvtafafFCYNYILFffLSWFPAYLVQAHGL 262
Cdd:cd06180 175 LRRGPSAPTEASAAESAPGLNRPLWRL-----------ALAYGL------------FGFGYIIT--ATFLPLIARETGAG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 263 NIKEMSLTTVIPwIVGFFGLALGGIISDKIfnltgRLLLSRKIVLVVSLLAAAICVALAGVVTRVVPAVMLmsvSIFFLY 342
Cdd:cd06180 230 SLLAGLLWSLFG-LAAVPSCFLWGALSDRW-----GTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLF---GGTFMA 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516061811 343 TTGAIYWAIIQdvVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVAALGAILVFFV 414
Cdd:cd06180 301 ITALVMALARE--LAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALLV 370
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
16-416 |
4.67e-06 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 48.38 E-value: 4.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 16 VYMINYLDRVALSITVPMIE---KELTINPEQFGMIfGSFffgYAIFNFLGGLAV----DKFGPTLVMGLAVGLWSIFCG 88
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSthiRSLGASPTVIGLI-GSV---YGALQLFSSPLVgswsDVVGRRPVLLICLLLTALGYV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 89 MTAIATGFYSMLILRVLFGMAEGPIcASANKMINGWFPKKQAATAMGLLSAGSPLgGAVAGPIVG-YLAisfGWRPAFMI 167
Cdd:cd17390 77 LLGFSTSLALLFLSRIPLGIFKHTQ-SLCKAYLSDLVSEQERSRVLGRFNAASSL-GFILGPVVGgHLA---ETDGGFYY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 168 IASIGivwMLVWFFTAAdnpekshrvteherqwvnrlktekindeedltqsaqtLGYYLrqPIILVTAFAF-FCYNYILF 246
Cdd:cd17390 152 VALLC---SAIFILNAG-------------------------------------LVWFL--LSKLWDLLLVrFLMGFSVL 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 247 FFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNLTGRLLLSRKIVLVVSLLaaaiCVALAGVVTR 326
Cdd:cd17390 190 LFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLL----GLALAPSIWL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 327 VVPAVMLMSVSIFFLYTTGAiywAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQntGHFDSAFILAGGVAAL 406
Cdd:cd17390 266 LVLCLTPLSISSAVLRTCST---SLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQE--FSVSGPGLLGAVLALA 340
|
410
....*....|
gi 516061811 407 GAILVFFVIK 416
Cdd:cd17390 341 AILLMLARQR 350
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
11-341 |
5.31e-06 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 48.50 E-value: 5.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 11 LLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVD-----KFGPTLVM--GLAVGLW 83
Cdd:PRK09556 32 LVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADgkntkQFLPFLLIlsAICMLGF 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 84 SIFCGMTAIATGFysMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLA-ISFGWR 162
Cdd:PRK09556 112 GASLGSGSVSLGL--MIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGAnYFFDGH 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 163 PAFMII--ASIGIVWMLVWFFTAADNPEkSHRVTEHERQWVNRLKTEKINDEE-DLTQSAQTLGYYLRQPIILVTAFAFF 239
Cdd:PRK09556 190 VIGMFIfpSIIALIIGFIGLRYGSDSPE-ELGWGKAEEIFGEPISEEDKETEStDMTKWQIFVEYVLKNPVIWLLCFANI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 240 cYNYILFFFL-SWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKifnLTGRlllsRKIVLVVSLLAAAICV 318
Cdd:PRK09556 269 -FLYIVRIGIdNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDL---ANGR----RALVACIALALIIFTL 340
|
330 340
....*....|....*....|...
gi 516061811 319 ALAGVVTrvvpAVMLMSVSIFFL 341
Cdd:PRK09556 341 GVYQHAT----SEYMYLASLFAL 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-180 |
6.81e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 6.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 1 MFKNLRWIIVLLLCLVYMINYLdrVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAV 80
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLALA--LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 81 GLWSIFCGMTAIA--TGFYSMLILRVLFGMAEGPICASANKMI-------NGWFPKKQAATAMGLLSAGSPLGGAVAGPI 151
Cdd:COG2211 302 LLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGAL 381
|
170 180 190
....*....|....*....|....*....|.
gi 516061811 152 VGYLAISFGWRPAFMIIASI--GIVWMLVWF 180
Cdd:COG2211 382 AGLLLALFGYVAGAAQSPSAltGIRLLFFLL 412
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
267-427 |
6.84e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.00 E-value: 6.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 267 MSLTTVIPWIVGFFGLALGGIISDKifnltgrlLLSRKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSVSIFFLYTTGA 346
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADR--------FDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 347 IYW----AIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQnTGHFDSAFILAGGVAALGAILVFFVIKPPKHQP 422
Cdd:cd06173 108 FFGparqALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVA-LLGPGGAFAINALSFLLSALLLLFIRRPPPAAP 186
|
....*
gi 516061811 423 QTRIS 427
Cdd:cd06173 187 GESSS 191
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
2-427 |
1.38e-05 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 47.01 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 2 FKNLRWIIVLLLCLVYMINYLDRVALSITVP-MIEKELTINpeQFGMIFGSFFFGYAIFNFLGGLAVDKFGPT--LVMGL 78
Cdd:PRK11273 23 YRRLRWQIFLGIFFGYAAYYLVRKNFALAMPyLVEQGFSRG--DLGFALSGISIAYGFSKFIMGSVSDRSNPRvfLPAGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 79 AVGLWSIFC-GMTAIATG-FYSMLILRVLFGMAEG---PICASAnkMINgWFPKKQAATAMGLLSAGSPLGGAVAGP--I 151
Cdd:PRK11273 101 ILAAAVMLFmGFVPWATSsIAVMFVLLFLCGWFQGmgwPPCGRT--MVH-WWSQKERGGIVSVWNCAHNVGGGLPPLlfL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 152 VGyLAISFGWRPAFMIIASIGIVWMLVWFFTAADNPEKSH--RVTEHERQWVNRLKTekiNDEEDLTQSAQTLGYYLRQP 229
Cdd:PRK11273 178 LG-MAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGlpPIEEYKNDYPDDYNE---KHEQELTAKQIFMQYVLPNK 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 230 IILVTAFA-FFCYnYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFN----LTGRLLLsrk 304
Cdd:PRK11273 254 LLWYIAIAnVFVY-LLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRgnrgATGVFFM--- 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 305 ivlvvsllaaaICVALAGVVTRVVPA-----VMLMSVSIFFLyttgaIYWAIIQDVVH------KSKVGSASGFIHLIGS 373
Cdd:PRK11273 330 -----------TLVTIATIVYWLNPAgnptvDMACMIVIGFL-----IYGPVMLIGLHalelapKKAAGTAAGFTGLFGY 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 516061811 374 VSG-IIGPIATGFIVQNTGhFDSAFILAGGVAALGAILVFFVIKPPKHQPQTRIS 427
Cdd:PRK11273 394 LGGsVAASAIVGYTVDFFG-WDGGFMVMIGGSILAVILLIVVMIGEKRHHEELLQ 447
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
26-181 |
1.58e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 46.87 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 26 ALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVL 105
Cdd:cd17476 16 SVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRAL 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516061811 106 FGMAEGPICASANKMINGWFPK-KQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIVWMLVWFF 181
Cdd:cd17476 96 QGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIF 172
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
31-414 |
1.60e-05 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 46.84 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 31 VPMIEKELTINPEQFGMIfGSFFFGYAIFN-FLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGma 109
Cdd:PLN00028 59 LPIIRDNLNLTKSDIGNA-GIASVSGSIFSrLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIG-- 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 110 egpICASANKMINGW----FPKKQAATAMGLLSAGSPLGGAVAG---PIVGYLAISFG------WRPAFMIIASIGIVWM 176
Cdd:PLN00028 136 ---FSLATFVSCQYWmstmFNGKIVGTANGIAAGWGNLGGGVTQllmPLVFPLIKDAGapsftaWRIAFFVPGLLHIIMG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 177 LVWFFTAADNPEKSHRvteherqwvnRLKtEKINDEEDLTQSAQTLGYYLRQPIILVTAFAfFCY-------NYILFFFL 249
Cdd:PLN00028 213 ILVLTLGQDLPDGNYR----------ELK-KSGTMPKDSFSKVLRYGVTNYRTWILALTYG-YSFgveltmdNIIAEYFY 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 250 SWFpaylvqahglnikEMSLTT--VIPWIVG---FFGLALGGIISDKI---FNLTGRLLlsrkIVLVVSLLAAAICVALa 321
Cdd:PLN00028 281 DRF-------------GLSLETagAIAASFGlmnLFARPAGGYLSDVAarrFGMRGRLW----ALWIVQTLGGVFCIWL- 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 322 GVVTRVVPAVMLMSV-SIFFLYTTGAIYwAIIQDVVHKSkVGSASGFIHLIGSVSGIIgpIATGFIVQNTGHFDSAFILA 400
Cdd:PLN00028 343 GRANSLGAAIVVMILfSIFVQAACGATF-GIVPFVSRRS-LGVISGLTGAGGNVGAVL--TQLLFFTGSSYSTETGISLM 418
|
410
....*....|....
gi 516061811 401 GGVAALGAILVFFV 414
Cdd:PLN00028 419 GVMIIACTLPVAFI 432
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
231-422 |
2.38e-05 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 46.07 E-value: 2.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 231 ILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISdKIFNLtgrlllsRKIVLVVS 310
Cdd:PRK03699 207 VLFLAIAALLYILAQLTFISWVPEYAQKKFGMSLEDAGNLVSNFWMAYMVGMWIFSFIV-RFFDL-------QRILTVLA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 311 LLAaaiCVALAGVVTRVVPAVMLMSVSIFFLYTTgAIYWAIIQDVVHKSKVGSAS--GFIHLIGSVSGIIGPIATGFIVQ 388
Cdd:PRK03699 279 GLA---LVLMYLFVNTDDPSHLLYAILGLGFFSS-AIYTTIITLGSQQTKVASPKlvNFILTCGTIGTMLTFVVTSPIVA 354
|
170 180 190
....*....|....*....|....*....|....
gi 516061811 389 NTGhFDSAFILAGGVAALGAILVFFVIKPPKHQP 422
Cdd:PRK03699 355 HFG-LQAALLTANGLYAVVFVMCILLGFVSKHRQ 387
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
36-415 |
2.43e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 46.06 E-value: 2.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 36 KELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFG---PTLVMGLAV-GLWSIFCGMTAIATGFysmLILRVLFGMAeG 111
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkrkLFIIIGLLFtVLASLIMILFPSPWGL---LIARFLSGIA-A 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 112 PICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIVWMLVWFFTAADNPEKSH 191
Cdd:cd17490 100 ATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 192 RVTEherqWVNRLKTekindeedltqsaqtlgyyLRQPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTT 271
Cdd:cd17490 180 VLTE----LKELLSV-------------------LKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 272 VIPWIVGFFGLALGGIISdkifnltGRLLLSRKIVLVVSLLAAAIC--VALAGVVTRVVPAVML--MSVSIFFLYTTGAI 347
Cdd:cd17490 237 IIYLLPNALASLLSGTLF-------YKKLGERNTIIIGFLLLGAYCflIPFAPNLTLLYLLQALngFGTGILFPLLMSLS 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516061811 348 ywaiIQDVVHKSKvGSASGFIHLIGSVSGIIGPIATGFIVQNTGhFDSAFILAGGVAALGAILVFFVI 415
Cdd:cd17490 310 ----IEGVPAEQR-STAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
316-414 |
3.25e-05 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 45.89 E-value: 3.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 316 ICVALAGVVTRVVPAVM----LMSVSIFF---LYTTGAIYWAII--QDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFI 386
Cdd:cd17422 255 ICVILLCVVLLLFPFAYgfwsLLVCSIFYgfmFGTVAGTHIPLLaeDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVL 334
|
90 100
....*....|....*....|....*...
gi 516061811 387 VQNTGHFDSAFILAGGVAALGAILVFFV 414
Cdd:cd17422 335 VDWTQNYGSAFYSCAAGMALGAVFLALV 362
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
1-174 |
7.53e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.52 E-value: 7.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 1 MFKNLRWIIVLLLC-LVYMINYLDRVALSitvPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGG-LAVDKFGPTLVMGL 78
Cdd:cd17490 190 VLKDKKLLFFSLLAiLQQMITFSTTFGFT---PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIII 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 79 AVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAIS 158
Cdd:cd17490 267 GFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEA 346
|
170
....*....|....*.
gi 516061811 159 FGWRPAFMIIASIGIV 174
Cdd:cd17490 347 FGLQTGFFVIGVIALL 362
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
34-414 |
8.00e-05 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 44.57 E-value: 8.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 34 IEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDK-FG---PTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMA 109
Cdd:cd17340 25 FIEDMDINTSQFMLLYSVYSWPNVVLCFFGGFLIDRvFGirlGTIIFSLLVLIGQLIFALGALTNLFWLMLVGRFIFGIG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 110 EGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVA----GPIVGYLAISFGWRPAF----MIIASIGIV-WMLVWF 180
Cdd:cd17340 105 GESLAVAQNTYAVSWFKGKELNLVFGLQLSFARIGSTVNfnvmPPIYKRISDFYSGYKSLgvalWIGAITCLFsLICAII 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 181 FTAADNpekshrvteherqwvNRLKTEKINDEEDLTQSAQTLGYYLRQPIILVTAFAFFCYNYIlFFFLSWFPAYLVQAH 260
Cdd:cd17340 185 LGLLDK---------------RAERILKKESNKTGEVIKLSDVKDFPLSFWLICIICVFYYVAV-FPFIGLGTVFFEEKY 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 261 GLNIKEMSLTTVIPWIVGFFGLALGGIISDKifnlTGRLLLSRKIVLVVSLLAAAICValagvVTRVVP--AVMLMSVSI 338
Cdd:cd17340 249 GFSPSEAAAVNSIVYIISAAASPVFGFLVDK----VGRNILWVLIALVITLLGHLLLA-----FTFVNPliAMVIMGIGY 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516061811 339 FFLYTTgaiYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHF--DSAFILAGGVAALGAILVFFV 414
Cdd:cd17340 320 SMLACA---LWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLllEVFFIACLCVSLIALIILYLV 394
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
36-181 |
8.58e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 44.62 E-value: 8.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 36 KELTINPEQFGMIFGSFFFGYAifnflgglaVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICA 115
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYL---------SDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWV 199
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516061811 116 SANKMINGWFPKKQAATAmGLLSAGSPLGGAVAGPIVGYLAISfgWRPAFMIIASIGIVWMLVWFF 181
Cdd:TIGR00898 200 QAVVLNTEFLPKKQRAIV-GTLIQVFFSLGLVLLPLVAYFIPD--WRWLQLAVSLPTFLFFLLSWF 262
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
67-412 |
1.02e-04 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 44.35 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 67 VDKFGPTLVMgLAVGLWSIfCGMtaIATGFYSMLI-----LRVLFGMAEGPICASANKMINGWFPKKQAaTAMGLLSAGS 141
Cdd:TIGR00892 78 VNRFGCRPVV-IAGGLLAS-LGM--ILASFSSNVIelyltAGFITGLGLAFNFQPSLTMLGKYFYRRRP-LANGLAMAGS 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 142 PLGGAVAGPIVGYLAISFGWRPAFMIIASI-------GIVWMLVWFFTAADNPEKSHRVTE--HERQWVNRLKTEKINDE 212
Cdd:TIGR00892 153 PVFLSTLAPLNQYLFESFGWRGSFLILGGLllhccvcGALMRPVGPSQRVSKSKSKEGLPPdgSTKKLSKKSTAEKINRF 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 213 EDLTQSAQTlGY--YLRQPIILVTAfaffcynyilFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISD 290
Cdd:TIGR00892 233 LDFSLFTHR-GFlvYLSGNVIMFLG----------FFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAG 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 291 kifnlTGRLLLSRKIVLVVSLLAAAIC---VALAGVVTRVVPAVMLMSVSIFFLyttGAIYWAIIQDVVHKSKVGSASGF 367
Cdd:TIGR00892 302 -----LKWIRPHVQYLFSFALLFNGLThllCALAGDYTGLVIYCIFFGLSFGSV---GALLFEVLMDLVGAQRFSSAVGL 373
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 516061811 368 IHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVAALGAILVF 412
Cdd:TIGR00892 374 VTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLA 418
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
145-412 |
1.37e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 145 GAVAGPIVGYLAISF---GWRPAFMIIASIGIVWMLVWFFTAADNPEKSHRvteherqwvnrlktekinDEEDLTQSAQT 221
Cdd:cd17370 136 GAVLGPLLAALLLYLlggNYRTIFLLAAIPALLALLILLFVVKEYPRPPKL------------------RKKSKKTSLKK 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 222 LGYYLRQPIILVTAFAFFCYNYIlffflswFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlll 301
Cdd:cd17370 198 LPKAFWLYLLAVALFALGNFSFA-------FLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRI--------- 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 302 SRKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPI 381
Cdd:cd17370 262 GRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASL 341
|
250 260 270
....*....|....*....|....*....|.
gi 516061811 382 ATGFIVQNTGHfDSAFILAGGVAALGAILVF 412
Cdd:cd17370 342 IAGYLWDLISP-SAAFLFSAVLALIALLLLL 371
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
32-181 |
1.40e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 43.75 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 32 PMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFG--PTLVMGLAV-GLWSIFCGMTAIATGFYSMLILRVLFGM 108
Cdd:PRK11102 15 PVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGrkPVILGGTLVfALAAVACALAQTIDQLIYMRFLHGLAAA 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516061811 109 AEGPIcasANKMINGWFPKKQAATAMG---LLSAGSPLggaVAGPIVGYLAISFGWRPAFMIIASIGIVW-MLVWFF 181
Cdd:PRK11102 95 AASVV---INALMRDMFPKEEFSRMMSfvtLVMTIAPL---LAPIIGGWLLVWFSWHAIFWVLALAAILAaALVFFF 165
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
238-423 |
1.72e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 43.34 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 238 FFCYNYILFFFLSWFPAYLVQAhGLNIKEMSLTTVIPWIVGFFGLALGGIISDKifnlTGRlllsRKIVLVVSLLAAAIC 317
Cdd:cd17335 6 YFFFFAALGSLLPFLSVYLKQL-GLSPTQIGILIGIRPFVRFLSAPLWGALADR----FGK----RKALLLLSLLAAVLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 318 VALAGVVTRVVPAVML-MSVSIFFLYTTGAIYWAIIQDVVHKSkvGSASGFIHLIGSVSGIIGPIATGFIVQNTGH---F 393
Cdd:cd17335 77 FLSLFFVAQIFWLLLLlVILGAFFSAPVVPLVDSITLQYLGEE--RERYGKQRLWGSIGFGIAALLVGILIDRSSTyknY 154
|
170 180 190
....*....|....*....|....*....|
gi 516061811 394 DSAFILAGGVAALGAILVFFVIKPPKHQPQ 423
Cdd:cd17335 155 TIAFYVFAVLMLLALLLALKFPFRPKHPEP 184
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
44-422 |
2.00e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.41 E-value: 2.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 44 QFGMIFGSFFFGYaifnflgglAVDKFG--PTLVMGLAVGLWSIFCGMTAIATGFYSMLIL-RVLFGMAEGPICASANKM 120
Cdd:pfam00083 56 SVGCFIGSLFAGK---------LGDRFGrkKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVgRVLVGIGVGGASVLAPMY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 121 INGWFPKKQAATAMGLLSAGSPLGGAVA---GPIVGYLAISFGWRPAF---MIIASIGIVWMLVW-----FFTAADNPEK 189
Cdd:pfam00083 127 ISEIAPKKLRGALGSLYQLAITFGILLAyifGLGLNKTSNSDGWRIPLglqLVPALLLIIGLLFLpesprWLVEKGRLEE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 190 SHRV------TEHERQWVNRLKT--EKINDEEDLTQSAQTLGYYLRQPIILVTAFAFF-CYNYILFFFLswFPAYLVQAH 260
Cdd:pfam00083 207 AREVlaklrgVPDVDRELDEIKDslEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFqQLTGINAIFY--YSTTIFENL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 261 GLniKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICVALAGVVTRVVPA---------- 330
Cdd:pfam00083 285 GL--SDSFLVTIIVGVVNFVFTFIAIFLVDRF---------GRRPLLLLGAAGMAICFVILGIVALLGVSksdwagivai 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 331 VMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSaFILAGGVAALGAIL 410
Cdd:pfam00083 354 VFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYT-FFIFAGLLVLFIIF 432
|
410
....*....|..
gi 516061811 411 VFFVIKPPKHQP 422
Cdd:pfam00083 433 VFFFVPETKGRT 444
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
52-183 |
2.05e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.95 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 52 FFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAA 131
Cdd:cd17317 34 FFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRS 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 516061811 132 TAMGLLSAGSPLGGAVAgPIVGYLAISfgWRPAFMIIASIGIVWMLVWFFTA 183
Cdd:cd17317 114 FVGILFGLFWALGYMLL-ALLAYLIRD--WRWLQLAISLPGLLFLLLLWWLP 162
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
235-427 |
3.24e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.97 E-value: 3.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 235 AFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIFNLTGRlllsRKIVLVVSLLAA 314
Cdd:COG2211 16 GLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGR----RRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 315 AICVALAGVVTRVVPAVML--MSVSIFFLYTTGAI----YWAIIQDVVHKSKV-GSASGFIHLIGSVSGIIGPIATGFIV 387
Cdd:COG2211 92 ALSFVLLFTAPDLSPTGKLiyALVTYLLLGLAYTLvnipYSALGAELTPDYEErTRLSSWRFAFAGLGGLLASVLPPPLV 171
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 516061811 388 QNTGHFDS-----AFILAGGVAALGAILVFFVIKPPKHQPQTRIS 427
Cdd:COG2211 172 AAFGGDAAlgyrlTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS 216
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
50-182 |
3.58e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.58 E-value: 3.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 50 GSFFFGYAI----FNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWF 125
Cdd:cd17489 230 GLFFTVYAIalllSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLV 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 516061811 126 PKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASIGIVWMLVWFFT 182
Cdd:cd17489 310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
43-414 |
3.78e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 42.17 E-value: 3.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 43 EQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMIN 122
Cdd:cd17502 30 SLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 123 GWFPKKQAATAMGLLSAGSPLGgAVAGPIVG-YLAISFGWRPAFMIIASIGIVwMLVWFftaadnpekshrvteherqwv 201
Cdd:cd17502 110 DLVPPRERGKYQGYIGAVFGIA-SVAGPLIGgAFTDHLSWRWCFYINLPIGGL-ALALL--------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 202 nrlktekindeedltqsaqtlgyylrqPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNiKEMSLTTVIPWIVGFfg 281
Cdd:cd17502 167 ---------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDS-ATKSGVRLLPLIIGL-- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 282 lALGGIISDKIFNLTGRLllsrKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSVSIFFLYTTGAIYWAI---IQDVVHK 358
Cdd:cd17502 217 -VIGSIISGALISKTGRY----KPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPlvaVQNAVPP 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 516061811 359 SKVGSASGFIHLIGSVSGIIGpiatgfivqntGHFDSAFILAGGVAALGAILVFFV 414
Cdd:cd17502 292 ADVGVATATNTFFRSLGGTLG-----------VAITDVFLVALALAALAFLLSLFL 336
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
89-413 |
5.33e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 5.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 89 MTAIATGFYSMLILRVLFGMAEGPICAsankMINGWFPKKQAATAMGLLSAGSPLGGaVAGPIVGYLAISFGWRP----- 163
Cdd:cd17313 102 TWALVLFVLGIVLLDFAMNVCQGPVRA----LLPDLVPPEQRSKANGIINFMGGLGG-VLGYLLGAILWDHNWFGfalgg 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 164 ----AFMIIASIGIVWMLVWFFTAADNPEKSHRVTEHERQWVNRLKTEKIndeedltQSAQTLGYYLRQpIILVTAFAFF 239
Cdd:cd17313 177 nlkvPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLL-------KLLKIMPRSLLR-LLLVIFFWWI 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 240 CYNYILFFFLSWfpAYLVQAHGLNIKEMSLTTVIPWivGFFGLALGGIISdKIFNLTGRLL---LSRKIVLVVSLLAAAI 316
Cdd:cd17313 249 AFFPFELFFTDY--MGEEVYHGTSAASSHYGAGVRM--GAWGLLIFSLAF-LIFSLPIGKLgkkIGRKKVYLIGLVLFAV 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 317 CVALAGVVTRVVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSK--VGSASGFIHLIGSVSGIIGPIATGFIVQNTGhFD 394
Cdd:cd17313 324 GMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGrgQGTDTGLLNLAISLAQILVSLLAGPIIDVKG-YG 402
|
330
....*....|....*....
gi 516061811 395 SAFILAGGVAALGAILVFF 413
Cdd:cd17313 403 TVFPVAAVASFLSLVGALF 421
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
231-414 |
6.02e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 6.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 231 ILVTAFAFFCYNYILFFFLswfPAYLVQAHGLNIkEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVS 310
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVL---PLYAHDLGGSEA-VAGLVVGLFTLAALLARPFAGRLLDRF---------GRKRLLLIG 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 311 LLAAAICVALAGVVTRVVP--AVMLMSVSIFFLYTTGAIywAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQ 388
Cdd:cd17489 68 LLIFALATLLYLLATSVALllVLRLIHGIGWGAFTTAAA--TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ 145
|
170 180
....*....|....*....|....*.
gi 516061811 389 NTGhFDSAFILAGGVAALGAILVFFV 414
Cdd:cd17489 146 HLG-FAVLFIVAAVLALLALLLVFLV 170
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
6-148 |
7.19e-04 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 41.62 E-value: 7.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 6 RWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSI 85
Cdd:cd17334 2 RWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNAL 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516061811 86 FCGMTAIATG----FYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVA 148
Cdd:cd17334 82 GSVLKCIPLGqqpkFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIG 148
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
319-410 |
1.27e-03 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 40.84 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 319 ALAGVVTRVVPAV----MLMSVSIFFLYTTGA---IYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTG 391
Cdd:cd17423 280 ALTGLSLLLLPLAkvygSLLALAVAYGFCAGAlapLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITG 359
|
90
....*....|....*....
gi 516061811 392 HFDSAFILAGGVAALGAIL 410
Cdd:cd17423 360 DYTASFLVAGSFLLLGSLI 378
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
130-356 |
1.80e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.28 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 130 AATAMGLLSAGSPLGGAVAGPIVGYL---AISFGWRPAFMIIASIGIVWMLVWFFTAadnpekshrvteHERQWVNRLKT 206
Cdd:cd17332 138 TSWRMFFATIGGLLVTVLPPPLVAYFgggNASRGYFLTALIIGIIGIILLLICFFGT------------RERVVPPEEEK 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 207 EKINDeedltqsAQTLGYYLRQPIILVTAFAFFCYNYILFFFLSWFPAYLVQAHGLNIKEMslttviPWIVGFFGLALGG 286
Cdd:cd17332 206 SKLPL-------LKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELV------LLLLLILSGALLA 272
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516061811 287 IISDKIFnltgRLLLSRKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSVSIFFLYTTGAIY--WAIIQDVV 356
Cdd:cd17332 273 LLPWPPL----KKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLlpWAMLADVI 340
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
237-415 |
2.13e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.14 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 237 AFFCYN---YILFFFLSwfpAYLVQAHGLNIKEMSLTTVIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLA 313
Cdd:COG2270 246 AYFFYRdgvQTVIAFAG---IYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRI---------GPKRVILVSLVI 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 314 AAICVALAGVVTRVVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHF 393
Cdd:COG2270 314 WIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQ 393
|
170 180
....*....|....*....|..
gi 516061811 394 dsafilaggVAALGAILVFFVI 415
Cdd:COG2270 394 ---------RLGILSLIVFFVI 406
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
11-182 |
2.14e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 40.21 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 11 LLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVgLWSIFCG-M 89
Cdd:cd17372 2 AYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISA-LWTFYAGfL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 90 TAIATGFYSMLILRVL--FGMAEGPICASankMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMI 167
Cdd:cd17372 81 SAFAPNYMWLIILRCLvgLGLGGGPQLAS---WYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAF 157
|
170
....*....|....*
gi 516061811 168 IASIGIVWMLVWFFT 182
Cdd:cd17372 158 SSVPSSLLLVFYRWT 172
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
36-177 |
2.19e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.83 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 36 KELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLILRVLFG----MAEG 111
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGlymgAQES 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516061811 112 PICASANKMIngwfPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFM---IIASIGIVWML 177
Cdd:cd17370 307 IERAAVADLV----PAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLfsaVLALIALLLLL 371
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
125-411 |
2.33e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 39.90 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 125 FPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMIIASI-GIVWMLVWFFTAADNPEKShrvteherqwvnr 203
Cdd:cd17485 121 LTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLLSLAALyLLLLLPVLFLRELELPQQP------------- 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 204 lktekiNDEEDLTQSAQTLGYYLRQPIILVTAFAFFCYNYILFFFLSWFPAYLVQaHGLNIKEMSL-TTVIPWIVGFFGL 282
Cdd:cd17485 188 ------PASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVD-RGFSLSQIGLlSGVGGSLVSIAGS 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 283 ALGGIISDKIFNLTGRLLLSRKIVLVVSLLAAAICVALAGVVTRVVPAVMLMSVSIFFLYTtgAIYwAIIQDVVHKSKVG 362
Cdd:cd17485 261 LLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGGMITT--ALF-TLMMDCSQQAQAG 337
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 516061811 363 SASGFIHLIGSVSGIIGPIATGFIVQNTGhFDSAFILAGGVAALGAILV 411
Cdd:cd17485 338 TDYTLLATVEVLGKLLFGSLAGFLADHLG-YAAAFLLFAILSALSVLLL 385
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
5-201 |
2.51e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 40.35 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 5 LRWIIVLLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWS 84
Cdd:TIGR01299 164 FQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNG 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 85 IFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGG----AVAGPIVGYLAISF- 159
Cdd:TIGR01299 244 FFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGiyaaAMAWAIIPHYGWSFq 323
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 516061811 160 --------GWRpAFMIIASIGIVWMLVWFFTAADNPEKSHRVTEHERQWV 201
Cdd:TIGR01299 324 mgsayqfhSWR-VFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWM 372
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
10-171 |
2.65e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 10 VLLLCLVYMINYLDRVALSITVPMIEK-ELTINPEQFGMIFGSFFFGYAIFN-FLGGLAVDKFGPTLVMGLAVGLWSIFC 87
Cdd:cd17330 176 LRRLLLVYFLIALAFAGLESVFSLFLKdRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 88 GMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRPAFMI 167
Cdd:cd17330 256 LLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL 335
|
....
gi 516061811 168 IASI 171
Cdd:cd17330 336 AAGL 339
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
55-161 |
3.08e-03 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 39.59 E-value: 3.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 55 GYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYSMLIL----RVLFGMAeGPICASANKMI-NGWFPKKQ 129
Cdd:cd17397 51 GFVPTFFFMAWLMDVKGLRIAVLSSAFLVAAGTGLRCIPVPNHLATWLihigQFLNGLA-GPVAMAAAPFLsATWFPPNQ 129
|
90 100 110
....*....|....*....|....*....|....*
gi 516061811 130 AATAMGLLSAGSPLGGAVA---GPIVgYLAISFGW 161
Cdd:cd17397 130 RATATAIASIFNYLGGAASfliGPLV-LMYLEFGW 163
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-148 |
3.40e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.32 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 1 MFKNLRWIIVLLLCLVYMINYldrvALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGP---TLVMG 77
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAFF----GLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRrrrLLLAL 272
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516061811 78 LAVGLWSIFCGMTAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGLLSAGSPLGGAVA 148
Cdd:pfam07690 273 LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
49-345 |
4.26e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 39.28 E-value: 4.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 49 FGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIFCGMTAIATGFYS--------MLILRVLFGMAEGPICASANKM 120
Cdd:cd17368 46 FGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATigiaapllVLLARLLQGFAAGGEVGGVTAY 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 121 INGWFPKKQAATAMGLLSAGSPLGgAVAGPIVGYLAI---------SFGWRPAFMIIASIGIVWMLVWFFTAADNPEKSH 191
Cdd:cd17368 126 LVEAAPPGRRGFYTSWQSASQQVA-IVAGALVGYLLSltltaealaEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLER 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 192 RVTEHERQWVNRLKTEKindeedltqSAQTLGYYlrqpIILVTAFAFfcynYILFFFlswFPAYLVQAHGLNIKEMSLTT 271
Cdd:cd17368 205 KARPTRRELFALLANNR---------RIILLGML----LVAGSTVTF----YFTTVY---TPTYAKTVLGLSARDSFLVT 264
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516061811 272 VIPWIVGFFGLALGGIISDKIfnltgrlllSRKIVLVVSLLAAAICV--ALAGVVTRVVPAVMLMSVSIFFLYTTG 345
Cdd:cd17368 265 LLAGVANFIWAPLGGALSDRI---------GRRPVLLVITLAALVTLypVFAWLTAAPSFGRLLLVLLVLSFFFGM 331
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
126-199 |
4.62e-03 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 39.31 E-value: 4.62e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516061811 126 PKKQAATAMGLLSAGSPLGGAVAG-PIVGYLAISFGWRPAFMIIASiGIVWMLVWFFTAADNPEKSHRVTEHERQ 199
Cdd:PRK11273 377 PKKAAGTAAGFTGLFGYLGGSVAAsAIVGYTVDFFGWDGGFMVMIG-GSILAVILLIVVMIGEKRHHEELLQKRN 450
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
303-416 |
6.68e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.40 E-value: 6.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 303 RKIVLVVSLLAAAICVALAGVVTRVVPAVML-MSVSIFFLYTTGAIywAIIQDVVHKSKVGSASGFIHlIGSVSG-IIGP 380
Cdd:cd17391 65 RKPMLLRASLGMAIVIGLMAFVTNVWQLLILrLLQGVFSGYVPNAT--ALIASQTPKEKSGWALGTLS-TGVVAGtLIGP 141
|
90 100 110
....*....|....*....|....*....|....*.
gi 516061811 381 IATGFIVQNTGhFDSAFILAGGVAALGAILVFFVIK 416
Cdd:cd17391 142 LLGGFLADLFG-IRNVFFITGGLLFLAFLLTLFFVK 176
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
11-178 |
6.73e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.34 E-value: 6.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 11 LLLCLVYMINYLDRVALSITVPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGPTLVMGLAVGLWSIF-CGM 89
Cdd:cd17365 174 LLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSlALL 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 90 TAIATGFYSMLILRVLFGMAEGPICASANKMINGWFPKKQAATAMGlLSAGSPLGGAVAGPIVGYLAISFGWRP-----A 164
Cdd:cd17365 254 GVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVG-WALGVGRLGAILGPLLGGLLLAAGLGPesvflA 332
|
170
....*....|....
gi 516061811 165 FMIIASIGIVWMLV 178
Cdd:cd17365 333 LAIPAALGALAVLL 346
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
31-181 |
7.77e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 38.35 E-value: 7.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 31 VPMIEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFG--PTLVMGLAVGLWSIFCGMTAiaTGFYSMLILRVLFGM 108
Cdd:PRK11652 31 IADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGrrPVILVGMSIFILGTLVALFA--HSLTVLIAASAIQGL 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516061811 109 AEGPICASANKMINGWFPKKQAATAMGLLSAG---SPLggaVAGPIVGYLAISFGWRPAFMIIASIGI-VWMLVWFF 181
Cdd:PRK11652 109 GTGVGGVMARTLPRDLYEGTQLRHANSLLNMGilvSPL---LAPLIGGLLTTLFGWRACYLFLLLLGAgVTFSMARW 182
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
12-181 |
8.15e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.39 E-value: 8.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 12 LLCLVYMINYLDRVALSITVPM-IEKELTINPEQFGMIFGSFFFGYAIFNFLGGLAVDKFGP---TLVMGLAVGLWSIFC 87
Cdd:cd17341 209 ILSLLYGVTFGSFVGFSNVLPTyFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGrrrLWWLFIVMTIGAALL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 88 GMTAIATGFYSM--LILRVLFGMAEGPICASANKMINGWFPkKQAATAMGLLSAGSPLGGAVAGPIVGYLAISFGWRP-A 164
Cdd:cd17341 289 SLSLPTSGTNLVlfLALFVALGLGAGAGNGSVFRMVPFIFR-RELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVgA 367
|
170
....*....|....*..
gi 516061811 165 FMIIASIGIVWMLVWFF 181
Cdd:cd17341 368 FSLFGVLAVACTLLVWL 384
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
255-413 |
9.05e-03 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 38.21 E-value: 9.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 255 YLV---QAHGLNIKEMSLTTVIPWIVGFFGLALGGIISD-KIFnlTGRLLLSRKIVLVVSLLAAAICVALAGVVTRVVpA 330
Cdd:cd17425 206 YLVpyaTSNGMDESKAALLLSILGFINIFMRPLAGLLSGlPVF--KGRRIYLFSLALLLNGLSNLICAISASFPVLLV-Y 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 331 VMLMSVSIFFLyttGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIVQNTGHFDSAFILAGGVAALGAIL 410
Cdd:cd17425 283 CLLYSISMSGI---GSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALF 359
|
...
gi 516061811 411 VFF 413
Cdd:cd17425 360 MGL 362
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
235-423 |
9.99e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 37.79 E-value: 9.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 235 AFAFFCYNYILFFFLSWFPAYLVQAHGLNIkEMSLTTVIPWIVGFFGLALGGIISDKIFnltgrlllsRKIVLVVSLLAA 314
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSAS-QLGLLFALFSLGYALLQPLAGLLADRFG---------RRPVLLLGLLLF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061811 315 AICVALAGVVTRVVPAVMLMSVSIFFLYTTGAIYWAIIQDVVHKSKVGSASGFIHLIGSVSGIIGPIATGFIV-QNTGHF 393
Cdd:cd06174 72 ALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAsSLGFGW 151
|
170 180 190
....*....|....*....|....*....|
gi 516061811 394 DSAFILAGGVAALGAILVFFVIKPPKHQPQ 423
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESAR 181
|
|
| |
