NCBI Conserved Domain Search

Conserved domains on [gi|516061913|ref|WP_017492496|]

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MFS transporter [Rouxiella badensis]

Protein Classification

MFS transporter( domain architecture ID 13022776)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH: 1.20.1250.20

Gene Ontology: GO:0022857|GO:0055085|GO:0016020

PubMed: 26758938|26098515|26234418

SCOP: 3000310

TCDB: 2.A.1

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

12-388

1.43e-59

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 197.44 E-value: 1.43e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  12 AIASFLSWTLDAFDFFLLVFLLSDIAT--SYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFE 89
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  90 LCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYS----VVGWRG 165
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 166 MFVIGAVPVLLLPFIyfkvqespvwlaarerhestallpvlkshWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFD 245
Cdd:cd17316  161 LFLIGALPALLALLL-----------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLS 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 246 AHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFA--GGSWTLGIGAFLMQFMVQGAWGVIPT 323
Cdd:cd17316  212 PATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYA 291

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516061913 324 YLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGhnyGLAMAMVAGTVAIVISVLVFF 388
Cdd:cd17316  292 YLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG---GTGVPALILALLAIVALIVAL 353

Name

Accession

Description

Interval

E-value

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

12-388

1.43e-59

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 197.44 E-value: 1.43e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  12 AIASFLSWTLDAFDFFLLVFLLSDIAT--SYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFE 89
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  90 LCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYS----VVGWRG 165
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 166 MFVIGAVPVLLLPFIyfkvqespvwlaarerhestallpvlkshWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFD 245
Cdd:cd17316  161 LFLIGALPALLALLL-----------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLS 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 246 AHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFA--GGSWTLGIGAFLMQFMVQGAWGVIPT 323
Cdd:cd17316  212 PATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYA 291

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516061913 324 YLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGhnyGLAMAMVAGTVAIVISVLVFF 388
Cdd:cd17316  292 YLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG---GTGVPALILALLAIVALIVAL 353

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

1-351

1.97e-43

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 154.75 E-value: 1.97e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   1 MFGWTSRQRNVAIASFLSWTLDAFDFFLLVFLLSDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMV 80
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  81 NILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSV 160
Cdd:COG2814   81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 161 VGWRGMFVIGAVP-VLLLPFIYFKVQESPVWLAARERHESTALLpvlksHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLK 239
Cdd:COG2814  161 FGWRWVFLVNAVLaLLALLLLLRLLPESRPAARARLRGSLRELL-----RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 240 VQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWG 319
Cdd:COG2814  236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315

                        330       340       350
                 ....*....|....*....|....*....|..
gi 516061913 320 VIPTYLTELVPANTRAVLPGFVYQLGNLIASV 351
Cdd:COG2814  316 LLQALVAELAPPEARGRASGLYNSAFFLGGPL 347

PRK03893

putative sialic acid transporter; Provisional

5-388

4.18e-39

putative sialic acid transporter; Provisional

Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 146.38 E-value: 4.18e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   5 TSRQRNVAIASFLSWTLDAFDFFLLVFLLSDIATSYHVDikDVTLAILLTLAV--RPIGALLFGRAAEKFGRKPVLMVNI 82
Cdd:PRK03893  15 NRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLT--TVQAASLISAAFisRWFGGLLLGAMGDRYGRRLAMVISI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  83 LFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVG 162
Cdd:PRK03893  93 VLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWG 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 163 WRGMFVIGAVPVLLLPFIYFKVQESPVWlaaRERHE-----------------------------------------STA 201
Cdd:PRK03893 173 WRALFFIGILPIIFALWLRKNLPEAEDW---KEKHAgkapvrtmvdilyrgehriinilltlaaaaalwfcfagnlqNAA 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 202 LLPVL----------------KSHWKLCVYL-VVLMAAFnFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGG 264
Cdd:PRK03893 250 IVAVLgllcaaifisfmvqssGKRWPTGVMLmVVVLFAF-LYSWPIQALLPTYLKTDLGYDPHTVANVLFFSGFGAAVGC 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 265 VTFGTLSERIGRKKAIIIAALLS-LPVLPLWAFAGGS-WTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVY 342
Cdd:PRK03893 329 CVGGFLGDWLGTRKAYVCSLLISqLLIIPVFAIGGANvWVLGLLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAGLGFTY 408

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 516061913 343 QLGNLIASVNATLQAYIAESHGhnYGLAMAMVAGTVAIVISVLVFF 388
Cdd:PRK03893 409 NVGALGGALAPILGALIAQRLD--LGTALASLSFSLTFVVILLIGL 452

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

60-360

1.47e-28

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 115.53 E-value: 1.47e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:TIGR00895  67 FGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLM 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  140 QAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAV-PVLLLPFIYFKVQESPVWL---------------AARERHESTALL 203
Cdd:TIGR00895 147 FCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIaPLLLLLLLMRFLPESIDFLvskrpetvrrivnaiAPQMQAEAQSAL 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  204 PVLKSHW----------------KLCVYLVVLMAAFNFFSHGTQDLYPtFLKVQHGFDAHTVSIIAICYNIASIIGGVTF 267
Cdd:TIGR00895 227 PEQKSTQgtkrsvfkalfqgktaRITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIF 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  268 GTLSERIGRkKAIIIAALLSLPVLPLWAFAGGSWTLGIGA-FLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGN 346
Cdd:TIGR00895 306 GWLADRLGP-RVTALLLLLGAVFAVLVGSTLFSPTLLLLLgAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGR 384

                         330
                  ....*....|....
gi 516061913  347 LIASVNATLQAYIA 360
Cdd:TIGR00895 385 LGAIIGPILAGYLL 398

Sugar_tr

pfam00083

Sugar (and other) transporter;

55-389

2.96e-24

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 103.89 E-value: 2.96e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   55 LAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAP---SLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRS 131
Cdd:pfam00083  56 SVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  132 RGLMSGIFQAGYPFGYLLA-GVVYGLLYSV--VGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHE---------- 198
Cdd:pfam00083 136 RGALGSLYQLAITFGILLAyIFGLGLNKTSnsDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEearevlaklr 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  199 -------------------------STALLPVLKSHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGF-DAHTVSII 252
Cdd:pfam00083 216 gvpdvdreldeikdsleagqeaekaSWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLsDSFLVTII 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  253 AICYNIASIIGGVtfgTLSERIGRKKAIIIAA---LLSLPVLPLWAFAG----GSWTLGIGAFLMQFMVQGAWGVIPT-- 323
Cdd:pfam00083 296 VGVVNFVFTFIAI---FLVDRFGRRPLLLLGAagmAICFVILGIVALLGvsksDWAGIVAIVFIALFIAFFAMGWGPVpw 372

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516061913  324 -YLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGHNYglaMAMVAGTVAIVISVLVFFG 389
Cdd:pfam00083 373 vIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGY---TFFIFAGLLVLFIIFVFFF 436

Name

Accession

Description

Interval

E-value

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

12-388

1.43e-59

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 197.44 E-value: 1.43e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  12 AIASFLSWTLDAFDFFLLVFLLSDIAT--SYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFE 89
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  90 LCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYS----VVGWRG 165
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 166 MFVIGAVPVLLLPFIyfkvqespvwlaarerhestallpvlkshWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFD 245
Cdd:cd17316  161 LFLIGALPALLALLL-----------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLS 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 246 AHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFA--GGSWTLGIGAFLMQFMVQGAWGVIPT 323
Cdd:cd17316  212 PATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYA 291

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516061913 324 YLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGhnyGLAMAMVAGTVAIVISVLVFF 388
Cdd:cd17316  292 YLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG---GTGVPALILALLAIVALIVAL 353

MFS_MucK

cd17371

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...

13-388

1.43e-51

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 177.49 E-value: 1.43e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  13 IASFLSWTLDAFDFFLLVFLLSDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCT 92
Cdd:cd17371    2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  93 AAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVV----GWRGMFV 168
Cdd:cd17371   82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLppeiAWRVLFL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 169 IGAVPVLLLPFIYFKVQESPVWLAARERHESTALLPVL-----KSHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHG 243
Cdd:cd17371  162 LGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLrelfsPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 244 FDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTL-GIGAFLMQFMVQGAWGVIP 322
Cdd:cd17371  242 LSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLiLILGFPLGFFASGPFSGMG 321

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516061913 323 TYLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAeSHGhNYGLAMAMVAGTVAIVISVLVFF 388
Cdd:cd17371  322 AYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLA-TSG-SLGTAIAVFAAVYYIAGLVLALL 385

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

1-351

1.97e-43

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 154.75 E-value: 1.97e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   1 MFGWTSRQRNVAIASFLSWTLDAFDFFLLVFLLSDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMV 80
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  81 NILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSV 160
Cdd:COG2814   81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 161 VGWRGMFVIGAVP-VLLLPFIYFKVQESPVWLAARERHESTALLpvlksHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLK 239
Cdd:COG2814  161 FGWRWVFLVNAVLaLLALLLLLRLLPESRPAARARLRGSLRELL-----RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 240 VQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWG 319
Cdd:COG2814  236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315

                        330       340       350
                 ....*....|....*....|....*....|..
gi 516061913 320 VIPTYLTELVPANTRAVLPGFVYQLGNLIASV 351
Cdd:COG2814  316 LLQALVAELAPPEARGRASGLYNSAFFLGGPL 347

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

5-386

2.05e-40

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 147.32 E-value: 2.05e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   5 TSRQRNVAIASFLSWTLDAFDFFLLVFLLSDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILF 84
Cdd:COG2271    5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  85 FSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWR 164
Cdd:COG2271   85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 165 GMFVIGAVPVLLLPFIYFkvqespvwlaarerhestallpvlkshWKLCVYLVVLMAAFNFFshgtQDLYPTFLKVQHGF 244
Cdd:COG2271  165 AAFLILGLPGLLLALLRF---------------------------WLLALAYFLVYFALYGF----LTWLPTYLVEVRGL 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 245 DAHTVSIIAICYNIASIIGGVTFGTLSERIGR--KKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIP 322
Cdd:COG2271  214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516061913 323 TYLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGHNYGLAMAMVAGTVAIVISVLV 386
Cdd:COG2271  294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357

PRK03893

putative sialic acid transporter; Provisional

5-388

4.18e-39

putative sialic acid transporter; Provisional

Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 146.38 E-value: 4.18e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   5 TSRQRNVAIASFLSWTLDAFDFFLLVFLLSDIATSYHVDikDVTLAILLTLAV--RPIGALLFGRAAEKFGRKPVLMVNI 82
Cdd:PRK03893  15 NRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLT--TVQAASLISAAFisRWFGGLLLGAMGDRYGRRLAMVISI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  83 LFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVG 162
Cdd:PRK03893  93 VLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWG 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 163 WRGMFVIGAVPVLLLPFIYFKVQESPVWlaaRERHE-----------------------------------------STA 201
Cdd:PRK03893 173 WRALFFIGILPIIFALWLRKNLPEAEDW---KEKHAgkapvrtmvdilyrgehriinilltlaaaaalwfcfagnlqNAA 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 202 LLPVL----------------KSHWKLCVYL-VVLMAAFnFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGG 264
Cdd:PRK03893 250 IVAVLgllcaaifisfmvqssGKRWPTGVMLmVVVLFAF-LYSWPIQALLPTYLKTDLGYDPHTVANVLFFSGFGAAVGC 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 265 VTFGTLSERIGRKKAIIIAALLS-LPVLPLWAFAGGS-WTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVY 342
Cdd:PRK03893 329 CVGGFLGDWLGTRKAYVCSLLISqLLIIPVFAIGGANvWVLGLLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAGLGFTY 408

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 516061913 343 QLGNLIASVNATLQAYIAESHGhnYGLAMAMVAGTVAIVISVLVFF 388
Cdd:PRK03893 409 NVGALGGALAPILGALIAQRLD--LGTALASLSFSLTFVVILLIGL 452

MFS_ShiA_like

cd17369

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...

48-386

4.85e-38

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 141.90 E-value: 4.85e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  48 TLAILLTLAV----RPIGALLFGRAAEKFGRKPVLMVNILFFSF----------FELCTAAAPSLTVflILRVIYGVAMG 113
Cdd:cd17369   43 TLAAFATFGVgflaRPLGGVVFGHFGDRIGRKKTLVLTLLLMGIatfligllptYAQIGILAPILLV--LLRLLQGLALG 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 114 GVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVV--------GWRGMFVIGAVPVLLLPFIYFKVQ 185
Cdd:cd17369  121 GEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLsdeaflswGWRIPFLLSAVLVAVGLYIRLRLE 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 186 ESPVWLAARERHESTALLP--VLKSHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIG 263
Cdd:cd17369  201 ETPVFRRAKEAGQVVRAPLveVLRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAIT 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 264 GVTFGTLSERIGRKKAIIIAALLS-LPVLPL-WAFAGGSWTLGIGAFLMQFMV--QGAWGVIPTYLTELVPANTRAVLPG 339
Cdd:cd17369  281 IPLFGWLSDRVGRRPVYLAGALLAaLFAFPFfWLLDTGSTWLIVLAAVVVLGVlhGMMYGPQAAFLAELFPTRVRYTGAS 360

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 516061913 340 FVYQLGNLIASVNATLQA-YIAESHGHNYGLAMAMVAGTVAIVISVLV 386
Cdd:cd17369  361 LGYQLGAILGGGFAPLIAtALVAATGSWWPVALYLAALAVISLVAALF 408

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

36-390

8.99e-34

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 130.00 E-value: 8.99e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  36 IATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGV 115
Cdd:COG2223   31 LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 116 WGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIY-FKVQESPVWLAAR 194
Cdd:COG2223  111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAwLFLRDPPAGAAAA 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 195 ERHESTALLPVLKSH--WKLCVYLVVLMAAFNFFSHGTqdlyPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSE 272
Cdd:COG2223  191 AKASLRDQLEALRDPrfWLLSLLYFGTFGSFIGFSSWL----PPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 273 RIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAW-GVIPTYLTELVPANTRAVLPGFVYQLGNLIASV 351
Cdd:COG2223  267 RIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGnGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFL 346

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 516061913 352 NATLQAYIAESHGhNYGLAMAMVAGTVAIVISVLVFFGR 390
Cdd:COG2223  347 GPLLFGALLDATG-SYTAAFLVFAVLALVALVLTLLLYR 384

PRK12307

MFS transporter;

44-406

4.86e-31

MFS transporter;

Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 123.11 E-value: 4.86e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  44 IKDVTLAILLTLAV--RPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASS 121
Cdd:PRK12307  50 LTDMEGAFLATAAFigRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACAST 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 122 LAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAAR----ERH 197
Cdd:PRK12307 130 YAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKlsgkGKH 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 198 ESTALLPVLKS------HWKLCVYLVVLMAAFNFFSHG--TQDLYPTFLkVQHGFDAHTVSIIAICYNIASIIGGVTFGT 269
Cdd:PRK12307 210 SQSAWSVFSLSmkglfnRAQFPLTLCVFIVLFSIFGANwpIFGLLPTYL-AGEGFDTGVVSNLMTAAAFGTVLGNIVWGL 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 270 LSERIGRKKAIIIAALLS-LPVLPLWAFAGGSWTL-GIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGNL 347
Cdd:PRK12307 289 CADRIGLKKTFSIGLLMSfLFIFPLFRIPQDNYLLlGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAAT 368

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 516061913 348 IASVNATLQAYIaeshGHNYGLAMAMVAGTVAIVISVLVFFGRDTQGKVINAASNAKAS 406
Cdd:PRK12307 369 SGTFNSMAATWL----GITMGLGAALTFIVAFWTATILLIIGLSIPDRLKARRESFQST 423

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

36-390

1.00e-28

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 115.75 E-value: 1.00e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  36 IATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGV 115
Cdd:cd17325   22 YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 116 WGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVI-GAVPVLLLPFIYFKVQESPVWLAAR 194
Cdd:cd17325  102 WPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVcAALALLALVLALLLLPEPRPPPNKR 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 195 ERHESTALLPVLKSHWKLCVYLVVLMAAFNFFSHGT-QDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSER 273
Cdd:cd17325  182 AVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGAlEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 274 IGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGNLIASVNA 353
Cdd:cd17325  262 IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGP 341

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 516061913 354 TLQAYIAESHGHNYGLAmamVAGTVAIVISVLVFFGR 390
Cdd:cd17325  342 LLGGFLYDAFGFATPFL---AAAALLLLAAVLFLLLR 375

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

60-360

1.47e-28

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 115.53 E-value: 1.47e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:TIGR00895  67 FGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLM 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  140 QAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAV-PVLLLPFIYFKVQESPVWL---------------AARERHESTALL 203
Cdd:TIGR00895 147 FCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIaPLLLLLLLMRFLPESIDFLvskrpetvrrivnaiAPQMQAEAQSAL 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  204 PVLKSHW----------------KLCVYLVVLMAAFNFFSHGTQDLYPtFLKVQHGFDAHTVSIIAICYNIASIIGGVTF 267
Cdd:TIGR00895 227 PEQKSTQgtkrsvfkalfqgktaRITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIF 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  268 GTLSERIGRkKAIIIAALLSLPVLPLWAFAGGSWTLGIGA-FLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGN 346
Cdd:TIGR00895 306 GWLADRLGP-RVTALLLLLGAVFAVLVGSTLFSPTLLLLLgAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGR 384

                         330
                  ....*....|....
gi 516061913  347 LIASVNATLQAYIA 360
Cdd:TIGR00895 385 LGAIIGPILAGYLL 398

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

34-388

3.01e-27

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 111.49 E-value: 3.01e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  34 SDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMG 113
Cdd:cd17324   23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 114 GVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMF-VIGAVPVLLLPFIYFKVQESPvwla 192
Cdd:cd17324  103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFlAIAVLALLAALLLWRLLPSLP---- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 193 aRERHESTALLPVLKSHWK-LCVYLVVLMAAFNFFSHGTQDLY-PTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTL 270
Cdd:cd17324  179 -PKKPGSLGLLSSLLLLLRnPRLRLAYLITFLLFGGFFALYTYlAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 271 SERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAV--LPGFVYQLGNli 348
Cdd:cd17324  258 ADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLAssLYLAAYNLGG-- 335

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 516061913 349 aSVNATLQAYIAeshgHNYGLAMAMVAGTVAIVISVLVFF 388
Cdd:cd17324  336 -ALGAALGGLVL----DHGGWAGVGWVGAALLLLALLLAL 370

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

60-386

1.55e-25

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 106.13 E-value: 1.55e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17365   49 IGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLM 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFkvqespvwlaarerheSTALLpvlkshWklCVYLVVL 219
Cdd:cd17365  129 FCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLR----------------GTLLL------W--VTFFMGL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 220 maafnFFSHGTQDLYPTFLkVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLS-LPVLPLWAFAG 298
Cdd:cd17365  185 -----LLVYLLNSWLPKLM-VEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGaVSLALLGVSPA 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 299 GSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESH-GHNYGLAMAMVAGT 377
Cdd:cd17365  259 SLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGlGPESVFLALAIPAA 338


                 ....*....
gi 516061913 378 VAIVISVLV 386
Cdd:cd17365  339 LGALAVLLL 347

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

60-386

8.16e-25

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 104.19 E-value: 8.16e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17319   53 LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLF 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKvqespvwlaarerhestallpVLKSHWKLCVYLVVL 219
Cdd:cd17319  133 NSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWF---------------------YLRQVWGLALGYFGI 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 220 MAAFNFFSHGTqdlyPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERI---GRKKAIIIAALLSLPVLPLWAF 296
Cdd:cd17319  192 NYALYGLLTWL----PTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYL 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 297 AGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAE-SHGHNYGLAMAMVA 375
Cdd:cd17319  268 TTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTAAFLFLAAV 347

                        330
                 ....*....|.
gi 516061913 376 GTVAIVISVLV 386
Cdd:cd17319  348 ALLAALLVLLL 358

MFS_KgtP

cd17367

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...

45-387

2.06e-24

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 103.91 E-value: 2.06e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  45 KDVTLAILLTLAV-------RPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLT--------VFLILRVIYG 109
Cdd:cd17367   33 GDPTVALLSTAAVfavgflmRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 110 VAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVV--------GWRGMFVIGAVPVLLLPFIY 181
Cdd:cd17367  113 LSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLgedqmaawGWRIPFLLGGVLAVVVLWLR 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 182 FKVQESPVWLAARERHE-STALLPVLKSHWK--LCVYLVVLMAAFNFFSHGTQdlYPTFLKVQHGFDAHTVSIIAICYNI 258
Cdd:cd17367  193 RGLEETESFEAIAESNEaSAGTLRELRRHPRelLLVVGLTAGGTLAFYTWTTY--LQKFLVNTAGFSKGDATWITTAALL 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 259 ASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQ----FMVQGAWGVIPTYLTELVPANTR 334
Cdd:cd17367  271 VFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALVlvglVFLSGYTSINAVVKAELFPTHVR 350

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 516061913 335 AVLPGFVYQLGNLIASVNATLQAYIAESHGHNYGLAMAMvagTVAIVISVLVF 387
Cdd:cd17367  351 ALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFFWYV---AGLIAISLVVY 400

Sugar_tr

pfam00083

Sugar (and other) transporter;

55-389

2.96e-24

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 103.89 E-value: 2.96e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   55 LAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAP---SLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRS 131
Cdd:pfam00083  56 SVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  132 RGLMSGIFQAGYPFGYLLA-GVVYGLLYSV--VGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHE---------- 198
Cdd:pfam00083 136 RGALGSLYQLAITFGILLAyIFGLGLNKTSnsDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEearevlaklr 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  199 -------------------------STALLPVLKSHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGF-DAHTVSII 252
Cdd:pfam00083 216 gvpdvdreldeikdsleagqeaekaSWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLsDSFLVTII 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  253 AICYNIASIIGGVtfgTLSERIGRKKAIIIAA---LLSLPVLPLWAFAG----GSWTLGIGAFLMQFMVQGAWGVIPT-- 323
Cdd:pfam00083 296 VGVVNFVFTFIAI---FLVDRFGRRPLLLLGAagmAICFVILGIVALLGvsksDWAGIVAIVFIALFIAFFAMGWGPVpw 372

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516061913  324 -YLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGHNYglaMAMVAGTVAIVISVLVFFG 389
Cdd:pfam00083 373 vIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGY---TFFIFAGLLVLFIIFVFFF 436

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

5-223

4.93e-24

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 101.04 E-value: 4.93e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   5 TSRQRNVAIASFLSWTLDAFDFFLLVFLLSDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILF 84
Cdd:COG0477    9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  85 FSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWR 164
Cdd:COG0477   89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 516061913 165 GMFVIGAVPVLLLPFIYFKVQESPVWLAARERHESTALLPVLKSHWKLCVYLVVLMAAF 223
Cdd:COG0477  169 WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLL 227

MFS_1

pfam07690

Major Facilitator Superfamily;

36-351

2.58e-23

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.80 E-value: 2.58e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   36 IATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGV 115
Cdd:pfam07690  23 LAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  116 WGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVI-GAVPVLLLPFIYFKVQESPVWLAAR 194
Cdd:pfam07690 103 FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIlAILSLLAAVLLLLPRPPPESKRPKP 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  195 ERHESTALLPVLKSHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERI 274
Cdd:pfam07690 183 AEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  275 GRKKAIIIAALLSLPV---LPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGNLIASV 351
Cdd:pfam07690 263 GRRRRLLLALLLLILAalgLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

36-384

7.37e-23

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 98.78 E-value: 7.37e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  36 IATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGV 115
Cdd:cd17478   22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 116 WGVASSLAMETIPDRsRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVwLAARE 195
Cdd:cd17478  102 HPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK-PEAKK 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 196 RHESTALLPVLKSHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLkVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIG 275
Cdd:cd17478  180 AAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYL-VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFG 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 276 RKKAIIIAALLSLPVLPLWAFAGGSWTLgIGAFLMQFMVQGAWGVIPTYLTELVPANtRAVLPGFVYQLGNLIASVNATL 355
Cdd:cd17478  259 RRRVIIASLLLAAPFLLLFLLTPGIWSY-ILLVLAGFLLFASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPV 336

                        330       340
                 ....*....|....*....|....*....
gi 516061913 356 QAYIAESHGHNYGLAMAMVAGTVAIVISV 384
Cdd:cd17478  337 LGALADAFGLESVLLILALLPLLGALLAF 365

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

16-388

6.76e-22

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 96.34 E-value: 6.76e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  16 FLSWTLDAFDFFLLVFLLSDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAA 95
Cdd:cd06174    2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  96 PSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYS--VVGWRGMFVIGAVP 173
Cdd:cd06174   82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 174 VLLLPFIYFKVQESPVWLAAR----ERHESTALLPVLKSHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTV 249
Cdd:cd06174  162 ALLAAILLLLVVPDPPESARAkneeASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 250 SIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPT-YLTEL 328
Cdd:cd06174  242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFaLIAEL 321

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 329 VPANTRAVLPGFVYQLGNLIASVNATLQAYIaesHGHNYGLAMAMVAGTVAIVISVLVFF 388
Cdd:cd06174  322 FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL---LAATFGLTGAFLVLAVLLLLAAILLL 378

PRK11551

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional

61-321

1.09e-20

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional

Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 93.10 E-value: 1.09e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  61 GALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQ 140
Cdd:PRK11551  66 GALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMY 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 141 AGYPFGYLLAGVVYGLLYSVVGWRGMFVI-GAVPVLLLPFIYFKVQESPVWLAAR----------------ERHESTALL 203
Cdd:PRK11551 146 CGVPFGGALASVIGVLAAGDAAWRHIFYVgGVGPLLLVPLLMRWLPESRAFAQAAgagkqrapvlralfgeGRATATLLL 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 204 pvlkshWKLCVY-LVVLMAAFNFFshgtqdlyPTFLkVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIII 282
Cdd:PRK11551 226 ------WISYFFtLIVLYFLLNWL--------PSLL-VGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLL 290

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 516061913 283 AALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVI 321
Cdd:PRK11551 291 IYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVL 329

MFS_CitA

cd17368

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...

46-348

1.98e-20

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 92.44 E-value: 1.98e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  46 DVTLAILLTLAV-------RPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLT--------VFLILRVIYGV 110
Cdd:cd17368   34 SEFASLLLTFATfgvgffmRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGF 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 111 AMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVV--------GWRGMFVIGAVPVLLLPFIYF 182
Cdd:cd17368  114 AAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSLTLtaealaewGWRIPFFIGLLIIPLGLWLRR 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 183 KVQESPVWLAARERHESTALLPVLKSHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASII 262
Cdd:cd17368  194 SLEETEAFLERKARPTRRELFALLANNRRIILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFI 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 263 GGVTFGTLSERIGRKKAIIIAALLSL----PVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLP 338
Cdd:cd17368  274 WAPLGGALSDRIGRRPVLLVITLAALvtlyPVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGF 353

                        330
                 ....*....|
gi 516061913 339 GFVYQLGNLI 348
Cdd:cd17368  354 SLVYALAVAI 363

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

60-392

7.90e-19

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 87.62 E-value: 7.90e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRsRGLMSGIF 139
Cdd:COG2807   68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLY 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVL--LLPFIYFKVQESPvwlAARERHESTALLPVLKShwKLCVYLV 217
Cdd:COG2807  147 TAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALlaLLLWLPLLRRRPA---AAAAAPAAASLRSLWRS--PLAWLLT 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 218 VLMAAFNFFSHGTQDLYPTFLkVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFA 297
Cdd:COG2807  222 LFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLL 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 298 GGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVP-ANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGhNYGLAMAMVAG 376
Cdd:COG2807  301 APGSLPWLWAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG-SWTAALLLLAA 379

                        330
                 ....*....|....*.
gi 516061913 377 TVAIVISVLVFFGRDT 392
Cdd:COG2807  380 LAVLMLVAGLLAGRPY 395

2A0119

TIGR00898

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

60-198

1.87e-18

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 86.99 E-value: 1.87e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLI 221

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 516061913  140 QAGYPFGYLLagvVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHE 198
Cdd:TIGR00898 222 QVFFSLGLVL---LPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIE 277

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

35-393

7.99e-18

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 84.52 E-value: 7.99e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  35 DIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGG 114
Cdd:COG0738   33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 115 VWGVASSLAMETIPDRSRGLMSgIFQAGYPFGYLLAGVVYGLLYSV---VGWRGMFVIGAVPVLLLpFIYFKVQESPVWL 191
Cdd:COG0738  113 LDVAANPYVAALGPETAASRLN-LLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLL-ALLFLRSKLPEIE 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 192 AARERHESTALLPVLKSHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLS 271
Cdd:COG0738  191 EEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLL 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 272 ERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLpGFVYQLGNLIASV 351
Cdd:COG0738  271 KRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAI 349

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 516061913 352 NATLQAYIAESHGHNYGLAMAMVAGTVAIVISVLVFFGRDTQ 393
Cdd:COG0738  350 GPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391

MFS_XylE_like

cd17359

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...

60-351

1.67e-17

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 83.39 E-value: 1.67e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17359   51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 Q--------AGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERhestallPVLkshwk 211
Cdd:cd17359  131 QlmivfgqlLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGK-------PIL----- 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 212 lcvYLVVLMAAFNFFSHGTQDLY--PTFLKvQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIII-----AA 284
Cdd:cd17359  199 ---IIGIGLAIFQQFVGINVIFYygPEIFQ-NAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIgsigmAI 274

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516061913 285 LLSLPVLPLWAFAGGSWT-LGIGAFLMQFMV--QGAWGVIP-TYLTELVPANTRAV---LPGFVYQLGNLIASV 351
Cdd:cd17359  275 SLLLIGTAFYFAPGSQASgIVALVLILLFVAffAMSWGPVTwVLLSEIFPNRIRGLamgIAVFFLWIANFLVSL 348

MFS_SLC22

cd17317

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...

60-388

1.58e-16

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 79.93 E-value: 1.58e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17317   40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILF 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVYgllYSVVGWRG-MFVIGAVPVLLLPFIYFkvqespvwlaarerhestalLPVLKshwkLCVYLVV 218
Cdd:cd17317  120 GLFWALGYMLLALLA---YLIRDWRWlQLAISLPGLLFLLLLWW--------------------LPRRT----IIVGLIW 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 219 LMAAFNFFSHgtqDLYPTFLkvqhGFDAHTVSIIAicyNIASIIGGVTFGTLSERIGRKKAIIIAALLS-LPVLPLWAFA 297
Cdd:cd17317  173 FVTSLVYYGL---SLNSSNL----GGNLYLNFFLS---GLVEIPAYFLALLLLDRLGRRWTLSGSLLLAgLACLVTALLP 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 298 GGSWTLGIGAFLM-QFMVQGAWGVIPTYLTELVPANTRAVLPGFVyqlgNLIASVNATLQAYIAeSHGHNYGLAMAMVAG 376
Cdd:cd17317  243 DDENTLALTLALVgKFAISAAFSVIYLYTAELYPTVVRNTGVGLC----STVARVGAILAPFIV-LLGKIGPLLPLIIFG 317

                        330
                 ....*....|..
gi 516061913 377 TVAIVISVLVFF 388
Cdd:cd17317  318 VLALLGGLLTLL 329

PRK10642

proline/glycine betaine transporter ProP;

57-408

2.78e-16

proline/glycine betaine transporter ProP;

Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 80.53 E-value: 2.78e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  57 VRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLT--------VFLILRVIYGVAMGGVWGVASSLAMETIP 128
Cdd:PRK10642  69 IRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAtigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSP 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 129 DRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVV--------GWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHES- 199
Cdd:PRK10642 149 DRKRGFMGSWLDFGSIAGFVLGAGVVVLISTIVgeanfldwGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQg 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 200 ----------TALLPVLKSHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGF-DAHTVSIIaicynIASIIGGV--- 265
Cdd:PRK10642 229 dreglqdgpkVSFKEIATKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYsEDHGVLII-----IAIMIGMLfvq 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 266 -TFGTLSERIGRKKAIIIAAlLSLPVLPLWAF----AGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGF 340
Cdd:PRK10642 304 pVMGLLSDRFGRRPFVILGS-VALFVLAIPAFilinSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAA 382

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516061913 341 VYQLGNLIASVNATLQAYIAESHGHNYGLA-MAMVAGTVAIVISvlvFFGRDTQGKVINAASNAkASDV 408
Cdd:PRK10642 383 AFNISVLVAGLTPTLAAWLVESTQNLMMPAyYLMVVAVIGLITG---VTMKETANRPLKGATPA-ASDI 447

MFS_OFA_like

cd17353

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...

36-386

6.18e-16

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 78.81 E-value: 6.18e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  36 IATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFG-RKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGG 114
Cdd:cd17353   29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGpRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 115 VWGVASSLAMETIPDRsRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFI---YFKVQESPVWL 191
Cdd:cd17353  109 GYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIgafLIRDPPKGWVP 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 192 AARERHESTALLPVLKSHWKLCV-----YLVVLMAAFN-FFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGV 265
Cdd:cd17353  188 PGVDPLANNAENSPRDYTPREMLrtptfWLLWLMFFLNaTAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRP 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 266 TFGTLSERIGRKKAIIIA-ALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQL 344
Cdd:cd17353  268 FWGWLSDKIGRKNTLSIAfLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTA 347

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 516061913 345 GNLIASVNATLQAYIAESHGHNYGLAMAMVAGTVAIVISVLV 386
Cdd:cd17353  348 KGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389

MFS_GLUT6_8_Class3_like

cd17358

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...

49-198

2.49e-15

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 77.23 E-value: 2.49e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  49 LAILLTLAVrPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIP 128
Cdd:cd17358   46 FGSLLTLGA-LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAP 124

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 129 DRSRGLMSGIFQAGYPFGYLLagvVYgLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHE 198
Cdd:cd17358  125 KNVRGALGSLNQLLVNIGILL---GY-VLGSFLPWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREE 190

MFS_OAT

cd17374

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...

59-182

8.80e-15

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 75.02 E-value: 8.80e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  59 PIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGI 138
Cdd:cd17374   49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITL 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 516061913 139 FQAGYPFGYLLAGvvyGLLYSVVGWRGMFVIGAVPVLLLpFIYF 182
Cdd:cd17374  129 TSCFFSIGQMLLA---GLAYAIRDWRLLQLVVSVPFFLF-FLYS 168

MFS_ProP

cd17366

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...

46-334

1.03e-14

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 75.09 E-value: 1.03e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  46 DVTLAILLTLA-------VRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPS--------LTVFLILRVIYGV 110
Cdd:cd17366   34 DPTAQLLATFAtfavaflVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTyatigvwaPILLLLARMVQGF 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 111 AMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVV--------GWRGMFVIGAvpVLLLPFIYF 182
Cdd:cd17366  114 STGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLLteaqmldwGWRIPFLIAA--PLGLVGLYL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 183 KvqespvwlaarerhestalLPVLKShwklcvylVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASII 262
Cdd:cd17366  192 R-------------------RPLLIC--------IGLVLVFNVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLV 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516061913 263 GGVTFGTLSERIGRKKaIIIAALLSLPVLPLWAF----AGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTR 334
Cdd:cd17366  245 LQPFLGRLSDRVGRKP-VYAAGLAGLLVLAVPAFllmnSGSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVR 319

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

35-390

2.45e-14

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 73.75 E-value: 2.45e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  35 DIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGG 114
Cdd:cd17321   21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 115 VWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGaVPVLLLPFIYfkvqeSPVWLAAr 194
Cdd:cd17321  101 IMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN-VPIGLVALLL-----ARTFSGA- 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 195 erhestALLPVLkshwklcvyLVVLMAAFNFFShgtqdlyPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERI 274
Cdd:cd17321  174 ------VLAAFL---------LGAALGGLLFLL-------PLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 275 GRKKAIIIAALL---SLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPG---FVYQLG--- 345
Cdd:cd17321  232 GPRLVLVAGLLLtavGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGilnTARQLGgal 311

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 346 ---------------NLIASVNATLQAYIAESHGHNYGLAMaMVAGTVAIVISVLVFFGR 390
Cdd:cd17321  312 gvallgalltaglsaNLGDSGVAALLSAAAAAFAAGFHLAF-LVAAALALLAALLALLLP 370

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

47-331

6.93e-14

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 73.01 E-value: 6.93e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  47 VTLAILLTLAVRPIGALLFGRAAEKFG-RKPVLMVNILFFSFFELCTAAAPSLT------VFLILRVIYGVAMGGVWGVA 119
Cdd:COG2211   52 LLVARLWDAITDPLIGALSDRTRTRWGrRRPWILIGAIPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPY 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 120 SSLAMETIPD-RSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVV------GWRGMFVIGAVPVLLLPFI-YFKVQESPVwl 191
Cdd:COG2211  132 SALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLtFFGTKERPV-- 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 192 AARERHESTALLPVLKSH---WKLCVYLVVLMAAFNFFShgtqDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFG 268
Cdd:COG2211  210 PEEEKVSLKESLKALLKNrpfLLLLLAYLLFFLALALVA----ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516061913 269 TLSERIGRKKAIIIAALLSLPVLPLWAFAGGS--WTLGIGAFLMQFMVQGAWGVIPTYLTELVPA 331
Cdd:COG2211  286 RLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGnlWLLLVLAALAGIGLGAILVLPWAMLADVVDY 350

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

35-335

7.49e-14

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 72.65 E-value: 7.49e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  35 DIATSYHVDIkdvTLAILLTLA---VRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVA 111
Cdd:cd17328   24 DIQSDFLIDD---SLAGLLQTVfiiSYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 112 MGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVV-GWRGMFVIGAVP-VLLLPFIYFKVQESPV 189
Cdd:cd17328  101 EASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLgVLLAILLLLFVREPPR 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 190 WLAARERHE---STALLPVLKSHWK-LCVYLVVLMAAFNFFSHGTQDLY-PTFLKVQHGFDAHTVSIIAICYNIASIIGG 264
Cdd:cd17328  181 GAAEGGVMAkstATSFLADLKALAKnPSFILSTLGFTAVSFVTGALAFWaPTFFLRAFGVGDLSSADVGLIFGAITCIAG 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 265 VtFGT-----LSERIGRK----KAII--IAALLSLP---VLPLWAFAGGSWTLGIGaFLMQFMVQGAWGVIPTYLTELVP 330
Cdd:cd17328  261 V-LGVllggiLADRLRRKtpraDPLVcaVGLLAAAPflfLALVLALSNLLLAWVLL-FLGEFLLSLNWAPVFAILLYVVI 338


                 ....*
gi 516061913 331 ANTRA 335
Cdd:cd17328  339 PTRRS 343

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

60-309

1.14e-13

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 71.82 E-value: 1.14e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17477   46 LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLY 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVYGlLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPvwlaARERHESTALLPVLKSHWKLCVYLVVl 219
Cdd:cd17477  126 STVLGLGFALGPLLLA-LVGTAGALPFLIAAVLLLLALVPLLLTRRAAP----EIEEAESISLRRLLRIAPLALLGAFV- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 220 maaFNFFSHGTQDLYPTFLkVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLP-VLPLWAFAG 298
Cdd:cd17477  200 ---AGFLEGAFYSLLPLYG-LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALaALLLPLVPG 275

                        250
                 ....*....|.
gi 516061913 299 GSWTLGIGAFL 309
Cdd:cd17477  276 LPLALLVLLFL 286

MFS_LmrB_MDR_like

cd17503

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...

35-388

1.38e-13

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 71.45 E-value: 1.38e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  35 DIATSYHVDIKDVTLAI---LLTLAVR-PIGALLfgraAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGV 110
Cdd:cd17503   21 TIMGDLGASLDTVQWVItsyLLALAIMiPLSGWL----ADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 111 AMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVI----GAVPVLLLPFIYFKVQE 186
Cdd:cd17503   97 GGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpiGILALLLAPLLDLRLFK 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 187 SPVWLAArerhestallpvlkshwklcvylVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVT 266
Cdd:cd17503  177 DRNFTLG-----------------------LLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 267 FGTLSERIGRKKAIIIAALLSL----------PVLPLWAFAGGSWTLGIG-AFLMQFMVQGAWGVIPTYLTELVPANTR- 334
Cdd:cd17503  234 VGRLLDKFGPRLLLLAGLLLLAlgtlllafltPDTSLWLIILPLFIRGLGmGLVFMPLNTLALNSLPPEQIGDATALFNt 313

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516061913 335 ----------AVLPGFVYQLGNLIASVNATLQAYIAESHGHNYGLAMAMVAGTVAIVISVLVFF 388
Cdd:cd17503  314 irqlggsigtALLATLLTNRTQFHHSRLSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLAL 377

MFS_MMR_MDR_like

cd17504

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...

36-386

1.53e-13

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 71.45 E-value: 1.53e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  36 IATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGgV 115
Cdd:cd17504   22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGA-V 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 116 WGVASSLAMETIPDRSR----GLMSGIFQAGYPFGYLLAGVVYGLLysvvGWRGMFVIGAVPVLLL----PFIYFKVQES 187
Cdd:cd17504  101 FPLAFALVREEFPPERVpvaqGILSATFGIGAGIGLPLGGWIVQHL----GWRWIFWTAAPVAVLLaalvPLIDLRLLRR 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 188 PVWLAArerhESTALLPVLkshwklcvylvVLMAAFNFFSHGTQDLYPTFLkvqhGFDAHTVSIIAICYNIASIIGGVTF 267
Cdd:cd17504  177 RNVLLA----NITALLAGF-----------GMFMVFQLLPQLLQLPTPTGF----GLGITEAGLLLLPGALVMLIAGPLA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 268 GTLSERIGRKKAIIIAALLSLPVLPLWAFAGGS-WTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGF---VYQ 343
Cdd:cd17504  238 GRLIARVGPRRVLLIGLVISAVGLLLLALLHSSlWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMntvLRT 317

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 516061913 344 LGNLIASVNATL------QAYIAESHGHNYGLAMAMVAGTVAIVISVLV 386
Cdd:cd17504  318 IGSAIGPAIAGAilttytVSITSGGVPTEGAYVLAFLIGAALALAALLL 366

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

60-390

3.03e-13

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 70.68 E-value: 3.03e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17473   50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVYGLLySVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHESTALLPVLKSHwKLCVYLVVL 219
Cdd:cd17473  130 SAAMSLGGVVFLLLGGAL-AEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKR-VLPIYFLAF 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 220 MAAFNFFSHGTQdlYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGG 299
Cdd:cd17473  208 LAMLLFYVIPIQ--LPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASG 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 300 SWTLGIGAFLMQFmvqGAWGVIPT---YLTELVPANTRAVLPGFVYQLGNLIASVNATL-QAYIAESHGHNyglAMAMVA 375
Cdd:cd17473  286 LWVVLLGAILAGL---GFGLLLPTlnsWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVlGPLVNLTGGLS---GAFLIL 359

                        330
                 ....*....|....*
gi 516061913 376 GTVAIVISVLVFFGR 390
Cdd:cd17473  360 GVLALVLAIVLLLLR 374

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

47-387

5.06e-13

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.93 E-value: 5.06e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  47 VTLAILLTLAVRPIGallfGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMET 126
Cdd:cd17489   37 VGLFTLAALLARPFA----GRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 127 IPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHESTALLPVL 206
Cdd:cd17489  113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 207 KSHwKLCVYLVVLMAAFNFFSHGTqdLYPTFLKVQHgfdAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALL 286
Cdd:cd17489  193 EKK-VLPPALILFLASIAYGAIST--FLPLYAAERG---ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 287 SLPVLPLWAFAGGSWTLGIGAFLMQFMvQGAwgVIPTYLTE---LVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESH 363
Cdd:cd17489  267 LALGLLLLSFAGSPWMLLLAAVLYGLG-FGL--LFPALQALavdLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF 343

                        330       340
                 ....*....|....*....|....
gi 516061913 364 GHNYGLAMAMVAGTVAIVISVLVF 387
Cdd:cd17489  344 GYRAMFLLAAVVVLLALVLYIFLL 367

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

46-385

5.83e-13

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 69.57 E-value: 5.83e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  46 DVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVN-----ILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVAS 120
Cdd:cd06173   35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQ 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 121 SLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAV----PVLLLPFIYFKVQESPVWLAARER 196
Cdd:cd06173  115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALsfllSALLLLFIRRPPPAAPGESSSLLL 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 197 HESTALLPVLKSHWKLcVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGR 276
Cdd:cd06173  195 RDLREGLRYLRRSPLL-RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRR 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 277 KKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGNLIASVNATLQ 356
Cdd:cd06173  274 GRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLA 353

                        330       340
                 ....*....|....*....|....*....
gi 516061913 357 AYIAESHGHNYGLAMAMVAGTVAIVISVL 385
Cdd:cd06173  354 GLLADALGLSAVFLLAGALLLLAALLLLL 382

MFS_GLUT_like

cd17315

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...

60-189

1.06e-12

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 68.75 E-value: 1.06e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17315   49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLN 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 516061913 140 QAGYPFGYLLAGVV-YGLLYSV-VGWRGMFVIGAVPVLLLPFIYFKVQESPV 189
Cdd:cd17315  129 QLMITFGILLAYLLgLALSLSPpGWWRLMFALAAVPALLQLLLMFFLPESRA 180

MFS_MT3072_like

cd17475

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...

60-332

1.36e-12

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 68.42 E-value: 1.36e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17475   46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIR 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVL---LLPFIYFKVQESPVWLAARERHESTALLPVLKSH--WKLCV 214
Cdd:cd17475  126 QTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSIlaaVLFWLFYREPPAASAATESASTLLRSLKEVLRNRdvWLIAI 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 215 YLVVLMA---AFNFFShgtqdlyPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERI--GRKKAII----IAAL 285
Cdd:cd17475  206 AGALLVApqfALLTFL-------LLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLvitaAIAA 278

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 516061913 286 LSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPAN 332
Cdd:cd17475  279 AALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPE 325

TIGR00879

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...

60-335

4.35e-12

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 67.36 E-value: 4.35e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   60 IGALLFGRAAEKFGRKPVLMVNILFF---SFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMS 136
Cdd:TIGR00879  86 IGALFAGWLSDRFGRKKSLLIIALLFvigAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALT 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  137 GIFQAGYPFGYLLA---GVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHE--------------- 198
Cdd:TIGR00879 166 SLYQLAITFGILVAygfGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEearkslarlrgtsge 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  199 ---------------STALLPVLKSHWKL---------CVYLVVLMAAFNFFSHGTQDLY--PTFLKvQHGFD---AHTV 249
Cdd:TIGR00879 246 dkelldelelidikrSIEKRSVQPSWGSLfsstrrirrRLFLGVVLQWFQQFTGINAIMYysPTIFE-NAGVStdhAFLV 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  250 SIIAICYNIASIIGGVtfgTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLG--------IGAFLMQFMVQGAWGVI 321
Cdd:TIGR00879 325 SIIVGAVNFAFTFVAI---FLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTGsskssgnvAIVFILLFIAFFAMGWG 401

                         330
                  ....*....|....*..
gi 516061913  322 PT---YLTELVPANTRA 335
Cdd:TIGR00879 402 PVpwvIVSEIFPLSLRP 418

MFS_Tpo1_MDR_like

cd17323

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...

34-330

8.76e-12

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 66.06 E-value: 8.76e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  34 SDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMG 113
Cdd:cd17323   23 PQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 114 GVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMF---VIGAVPVLLLPFIYFKvqesPVW 190
Cdd:cd17323  103 SPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFwflAIISGFCLILIFLFLP----IVL 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 191 LaarerhestallpvlkshwkLCVYLVVLMAAFNFFSHGtqdlYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTL 270
Cdd:cd17323  179 L--------------------LGLYVGLVYAILYLFLTA----FPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 271 SERIGRKKAI-----------IIAALLSLPVLP--LWAFAggsWTLG---------IGAFLMQFMVQGAWGVIPTYLTEL 328
Cdd:cd17323  235 SDYYYRRLKKknggkpepearLPPAFIGAFLFPigLFIFG---WTIYphihwivpiIGSAFFGFGLMLIFQSSLTYLVDS 311


                 ..
gi 516061913 329 VP 330
Cdd:cd17323  312 YP 313

MFS_SVOP

cd17441

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...

64-336

9.24e-12

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 65.99 E-value: 9.24e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  64 LFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVwGVASSLAMETIPDRSRG----LMSGIF 139
Cdd:cd17441   53 LWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGV-PQSVTLYAEFLPMKSRAkcilLIEVFW 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVYGLLysvvGWRGMFVIGAVPVLLLPFIYFkvqespvWLAARERHESTALLPVLKSHWKLCVYLVVL 219
Cdd:cd17441  132 ALGTVFEVLLAVFVMPTL----GWRWLLILSALPLLIFAVLCF-------WLPESARYWTTILLWFIWFSNAFSYYGLVL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 220 MAAFNF------------FSHGTQDLYPTFLKVQHGFDAHTVSiiaicynIASIIGGVTFGTLSERIGRKKAIIIA-ALL 286
Cdd:cd17441  201 LTTELFqagdvcsgssgkKVEGKCSLECEYLTTSDYMDLLWTT-------LSEFPGLLVTLWIIDRFGRKKTMALCfFVF 273

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 516061913 287 SLPVLPLWaFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAV 336
Cdd:cd17441  274 SFCTLLLF-SCVGRFSLTVLLFIARAFISGGFQAAYVYTPEVYPTATRAL 322

MFS_GLUT_Class1_2_like

cd17357

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...

60-348

1.01e-11

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 66.13 E-value: 1.01e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFF---SFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMS 136
Cdd:cd17357   64 IGSFISAFLANRFGRKNGLLISNALLvvsSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 137 GIFQAGYPFGYLLAGVVY--GLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWL----------------------- 191
Cdd:cd17357  144 SLTQIGVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLliskgdeeeaekslkflrgiedd 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 192 ------------AARERHESTALLPVLKS---HWKLCVyLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICY 256
Cdd:cd17357  224 vdqeleeikkesEQMGDQKQVSLMQLLRDpslRLPLLL-VLVVSASQQFSGINAIFFYSTFIFENAGFSPQLAEWANLGI 302

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 257 NIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFA--------GGSWTLGIGAFLMQFMVQGAWGVIPTYLT-E 327
Cdd:cd17357  303 GIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFlflseqnsWMSYGCIVAIFLFIFFFAIGLGPIPWFIGaE 382

                        330       340
                 ....*....|....*....|....
gi 516061913 328 LVPANTRAV---LPGFVYQLGNLI 348
Cdd:cd17357  383 LFPQAPRSAaqsLGSSVNWTSNFI 406

MFS_SVOP_like

cd17372

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...

17-182

1.18e-11

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 65.63 E-value: 1.18e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  17 LSWTLDAFDFFLLVFLLSDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAP 96
Cdd:cd17372    6 MGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  97 SLTVFLILRVIYGVAMGGVwGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLL 176
Cdd:cd17372   86 NYMWLIILRCLVGLGLGGG-PQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSL 164


                 ....*.
gi 516061913 177 LPFIYF 182
Cdd:cd17372  165 LLVFYR 170

PRK09952

shikimate transporter; Provisional

48-288

1.36e-11

shikimate transporter; Provisional

Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 65.91 E-value: 1.36e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  48 TLAILLTLAV----RPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLT--------VFLILRVIYGVAMGGV 115
Cdd:PRK09952  63 TLAAFATFGVgflfRPLGGVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFStigwwapvLLVTLRAIQGFAVGGE 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 116 WGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVV--------GWRGMFVIGAVPVLLLPFIYFKVQES 187
Cdd:PRK09952 143 WGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMTtdeqflswGWRIPFLFSIVLVLIALWVRNGMEES 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 188 PVWLAARERHESTAL-LPVLKShwklcvylvvlmaafnFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICY---------- 256
Cdd:PRK09952 223 AEFEQQQHEQAAAKKrIPVIEA----------------LLRHPGAFLKIIALRLCELLTMYIVTAFALNYstqnlglpre 286

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 516061913 257 ---NIASIIGGVT------FGTLSERIGRKKAIIIAALLSL 288
Cdd:PRK09952 287 lflNIGLLVGGLScltipcFAWLADRFGRRRVYITGALIGT 327

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

49-330

1.76e-11

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 65.36 E-value: 1.76e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  49 LAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVwGVASSLAMETIP 128
Cdd:cd17391   40 LAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYV-PNATALIASQTP 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 129 DRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVpVLLLPFIY--FKVQE--SPVwlaarERHESTALLP 204
Cdd:cd17391  119 KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGG-LLFLAFLLtlFFVKEdfKPV-----EKKKMVSTKE 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 205 VLKS--HWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSI---IAICYNIASIIGGVTFGTLSERIGRKKA 279
Cdd:cd17391  193 VWNSvpNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFIsglVFSATGVSSLLSAPRLGKLGDRIGHHRI 272

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 516061913 280 IIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVP 330
Cdd:cd17391  273 LLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITP 323

2_A_01_02

TIGR00880

Multidrug resistance protein;

60-176

6.52e-11

Multidrug resistance protein;

Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 59.97 E-value: 6.52e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:TIGR00880  13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLM 92

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 516061913  140 QAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLL 176
Cdd:TIGR00880  93 SAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALA 129

MFS_HXT

cd17356

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...

60-284

6.58e-11

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 63.42 E-value: 6.58e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSF-FELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGI 138
Cdd:cd17356   60 FGALISSFLSDRIGRKKSIQIGCVIYIIgAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSL 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 139 FQAGYPFGYLLAG-VVYGL--LYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLaarerhestallpvlkshWKLCvy 215
Cdd:cd17356  140 YQLAITIGILVAYcINYGThkLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWL------------------YRTI-- 199

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516061913 216 LVVLMAAFN-------FFSHGTQDLYPTFLKvqhGFDAHTVSIIAICYNIASIIGGVTFgtlSERIGRKKAIIIAA 284
Cdd:cd17356  200 LGIMLQLFQqltginyFFYYGTTIFQSTGLT---GSSPLLTSIILYIVNFVSTIPGLFF---VDKFGRRTCLLIGA 269

MFS_MdfA_MDR_like

cd17320

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...

35-314

6.81e-11

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 63.36 E-value: 6.81e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  35 DIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGG 114
Cdd:cd17320   24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 115 VWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAAR 194
Cdd:cd17320  104 GSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKR 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 195 ERHESTAL---LPVLKSH--WKLCVYLVVLMAAFNFFSHGTQDLYPTflkvQHGFDAHTVSIIAICYNIASIIGGVTFGT 269
Cdd:cd17320  184 KPLLSSLLrayKRVLKNRrfLGYALALGLSFAGLFAYLAAAPFIYIE----QLGLSPAQFGLLFALNAIALILGSLLNGR 259

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 516061913 270 LSERIGRKKAIIIAALLSLP---VLPLWAFAGGSWTLGIGAFLMQFMV 314
Cdd:cd17320  260 LVRRFGPRRLLRLGLLLLLAaalVLLLAALLGGLSLWPLVAPLFLIFF 307

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

37-176

1.28e-10

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 62.56 E-value: 1.28e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  37 ATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVW 116
Cdd:cd17370  226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 117 GVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLL 176
Cdd:cd17370  306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365

MFS_HMIT_like

cd17360

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...

60-194

4.75e-10

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 60.75 E-value: 4.75e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMggvwGVASSLA----METIPDRSRGLM 135
Cdd:cd17360   50 VGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGV----GIASMTVplyiAEAAPPRIRGRL 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 136 SGIFQAGYPFGYLLAGVVYGLL-YSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAAR 194
Cdd:cd17360  126 VTINVLFITGGQFVAYVINGAFsYLPGGWRWMLGLAAVPAVLQFIGLLFLPESPRWPSTR 185

MFS_Azr1_MDR_like

cd17502

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...

47-290

4.93e-10

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 60.65 E-value: 4.93e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  47 VTLAILLTLAVrpiGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMET 126
Cdd:cd17502   35 VGTAYLLTSTA---FQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 127 IPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGavpvllLPFIYFkvqespvwlaarerheSTALLPVL 206
Cdd:cd17502  112 VPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYIN------LPIGGL----------------ALALLRTI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 207 kshwkLCVYLVVLMAAFNFFshgTQDLY-PTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAAL 285
Cdd:cd17502  170 -----LLSSIFGFLFGGALF---GLIYYlPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGT 241


                 ....*
gi 516061913 286 LSLPV 290
Cdd:cd17502  242 ILMSV 246

MFS_SLC22A1_2_3

cd17379

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...

60-181

9.48e-10

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 59.67 E-value: 9.48e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17379   48 IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVY 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 516061913 140 QAGYPFGYLLagvVYGLLYSVVGWRGMFVIGAVPVLLLPFIY 181
Cdd:cd17379  128 QMFFTLGLLI---LPGIAYFIPHWRWLQLAVTLPNFLFLLYY 166

MFS_SLC22A6_OAT1_like

cd17446

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...

60-181

9.69e-10

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 59.74 E-value: 9.69e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17446   48 VGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVGTLL 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 516061913 140 QAGYPFGYLLagvVYGLLYSVVGWRGMFVIGAVPVLLLpFIY 181
Cdd:cd17446  128 GYCYTLGQLI---LAGVAYAIRDWRWLQLAVSLPFFIF-FLY 165

MFS_OPA_SLC37

cd17312

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...

60-387

1.37e-09

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 59.21 E-value: 1.37e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17312   53 VGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIW 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVYGLLYSVVGWR-GMFVIGAVPVLLLPFIYFKVQESPvwlaarerhestallPVLkshWKLC-VYLV 217
Cdd:cd17312  133 STSHNFGGILAPILAASLASYYGWRaAFLVPGIVGLVVAIILFFFLRDSP---------------PYV---WVLSlAYAF 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 218 VLMAAFNFFSHGtqdlyPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKK----AIIIAALLSLPVLPL 293
Cdd:cd17312  195 VYIVRYACLDWG-----PLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRrapiAVIYMLLMTLSLALF 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 294 WAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRA-VLPGFVYQLGNLIASVNATLQAYIAESHGHNyGLAMA 372
Cdd:cd17312  270 WFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAgTATGFVGLFGYLGASLAGLPLGYIIDHYGWS-TVFYF 348

                        330
                 ....*....|....*
gi 516061913 373 MVAGTVAIVISVLVF 387
Cdd:cd17312  349 LISAALLSVLLLLSL 363

MFS_YajR_like

cd17472

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...

65-385

1.39e-09

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 59.15 E-value: 1.39e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  65 FGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGvaMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYP 144
Cdd:cd17472   52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMALIGASIG 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 145 FGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLL-LPFIYFKVQESPVWLAARERhESTALLPVLKSHWKLCVYLV------ 217
Cdd:cd17472  130 IAFAISMVLGPLLAAHLGVSGLFLITAILSLVsLLILLFFVPDPPKIVQISEK-EKKKLKKLLKNKRLLRLDFSifilhf 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 218 VLMAAFNffshgtqdLYPTFLKvQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAA--LLSLPVLPLWA 295
Cdd:cd17472  209 VLMAFFY--------ILPLLLT-QLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSilLIAVGFLLLLF 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 296 FAGGSWTLGIGA--FLMQFMVQGAwgVIPTYLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGHNYGLAMAM 373
Cdd:cd17472  280 AATSLWLLIIGLiiFFIGFNLLEA--LLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTIL 357

                        330
                 ....*....|..
gi 516061913 374 VAGTVAIVISVL 385
Cdd:cd17472  358 ILALLWLLVSFL 369

PRK10406

alpha-ketoglutarate transporter; Provisional

57-382

1.53e-09

alpha-ketoglutarate transporter; Provisional

Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 59.44 E-value: 1.53e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  57 VRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTV--------FLILRVIYGVAMGGVWGVASSLAMETIP 128
Cdd:PRK10406  75 MRPIGGWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETigtwapalLLLARLFQGLSVGGEYGTSATYMSEVAV 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 129 DRSRGlmsgiFQAGYPFGYLLAGVVYGLLYSVV-------------GWRGMFVIGAvpVLLLPFIYFKVQESPVWLAARE 195
Cdd:PRK10406 155 EGRKG-----FYASFQYVTLIGGQLLALLVVVVlqqtledaelrewGWRIPFALGA--VLAVVALWLRRQLDETSQQETR 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 196 RHESTALLPVLKSHWKLCVYLVVLMAA--FNFFSHGTqdLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSER 273
Cdd:PRK10406 228 ALKEAGSLKGLWRNRRAFIMVLGFTAAgsLCFYTFTT--YMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDK 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 274 IGRKKAIII----AALLSLPVL--------PLWAFAGGSWTLGIGAFLMQFMvqgawGVIPtylTELVPANTRAVLPGFV 341
Cdd:PRK10406 306 IGRRTSMLCfgslAALFTVPILsalqnvssPYAAFGLVMCALLIVSFYTSIS-----GILK---AEMFPAQVRALGVGLS 377

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 516061913 342 YQLGNLIASVNA-----TLQAYIAESHGHNYGLAMAMVAGTVAIVI 382
Cdd:PRK10406 378 YAVANALFGGSAeyvalSLKSIGMETAFFWYVTLMAVVAFLVSLML 423

MFS_GLUT10_12_Class3_like

cd17362

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...

60-190

3.25e-09

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 58.13 E-value: 3.25e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17362   54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLK 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 516061913 140 QAGYPFGYLLAGVV-YGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVW 190
Cdd:cd17362  134 ELFIVLGILLGYVSgYAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRW 185

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

140-382

4.04e-09

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 57.94 E-value: 4.04e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVygLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHESTALLPVLKSHWKLCVYLVVL 219
Cdd:cd17370  134 TLGAVLGPLLAALL--LYLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVAL 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 220 MAAFNFFshgtqDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGG 299
Cdd:cd17370  212 FALGNFS-----FAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSS 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 300 SWTLGIGAFLMqFMVQGAW-GVIPTYLTELVPANTRAV---LPGFVYQLGNLIASVnatLQAYIAESHGHNYGLAMAMVA 375
Cdd:cd17370  287 LWLLLLGFILW-GLYMGAQeSIERAAVADLVPAELRGTaygLFNTVVGIGWLLASL---IAGYLWDLISPSAAFLFSAVL 362


                 ....*..
gi 516061913 376 GTVAIVI 382
Cdd:cd17370  363 ALIALLL 369

MFS_MFSD3

cd17485

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...

121-317

7.43e-09

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 57.24 E-value: 7.43e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 121 SLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLL--LPFIYFKVQESPVWLAARERHE 198
Cdd:cd17485  115 GLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLLSLAALYLLllLPVLFLRELELPQQPPASERGA 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 199 stALLPVLKSHWKL--CVYLVVLMAAFNFFSHGTQDLYPTFLkVQHGFDAHTVSIIA-ICYNIASIIGGVTFGTLSERIG 275
Cdd:cd17485  195 --ALKASLRAFLRRpgTRWLLLFLLLYKLGEQGALAMLPPFL-VDRGFSLSQIGLLSgVGGSLVSIAGSLLGGYLLKRRG 271

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 516061913 276 RKKAIII-----AALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGA 317
Cdd:cd17485  272 RRRLLLLggllrLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGGM 318

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

60-340

7.43e-09

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 56.82 E-value: 7.43e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVwGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17330   49 LASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGII 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVpVLLLPFIYfkvqespvwlaarerheSTALLPVLkshWKLCVYLVVL 219
Cdd:cd17330  128 SAAFGLGFILGPALGGFLSTPYGYALPFLVAAA-LALLNLVL-----------------VLFFLPPL---RRLLLVYFLI 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 220 MAAFNFFshgtQDLYPTFLKVQHGFDAHTVSI-IAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAG 298
Cdd:cd17330  187 ALAFAGL----ESVFSLFLKDRFGFSPSQIGLlLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFAS 262

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 516061913 299 GSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGF 340
Cdd:cd17330  263 SVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGI 304

PRK09874

multidrug efflux MFS transporter MdtG;

49-310

7.48e-09

multidrug efflux MFS transporter MdtG;

Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 57.24 E-value: 7.48e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  49 LAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVaMGGVWGVASSLAMETIP 128
Cdd:PRK09874  58 LVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQVP 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 129 DRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAvPVLLLPFIY--FKVQESPVWLAARERHESTALLPVL 206
Cdd:PRK09874 137 RNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITA-SVLFLCFLVtlFCIRENFQPVSKKEMLHMREVVTSL 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 207 KSHwKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSI---IAICYNIASIIGGVTFGTLSERIGRKKAIIIA 283
Cdd:PRK09874 216 KNP-KLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNIAFIsgmIASVPGVAALLSAPRLGKLGDRIGPEKILITA 294

                        250       260
                 ....*....|....*....|....*..
gi 516061913 284 ALLSLPVLPLWAFAGGSWTLGIGAFLM 310
Cdd:PRK09874 295 LIFSVLLLIPMSFVQTPLQLGILRFLL 321

xylE

PRK10077

D-xylose transporter XylE; Provisional

60-198

1.26e-08

D-xylose transporter XylE; Provisional

Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 56.62 E-value: 1.26e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMV-NILF-----------FSFFELCTAAAPSLTVFLILRVIYGVamgGVwGVASSLA---- 123
Cdd:PRK10077  70 IGGALGGYCSNRFGRRDSLKIaAVLFfisalgsawpeFGFTSIGPDNTGYVPEFVIYRIIGGI---GV-GLASMLSpmyi 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 124 METIPDRSRGLMSGIFQAGYPFGYLlagVVYGLLYSV-----------VGWRGMFVIGAVPVLLLPFIYFKVQESPVWLA 192
Cdd:PRK10077 146 AEIAPAHIRGKLVSFNQFAIIFGQL---VVYFVNYFIarsgdaswlntDGWRYMFASEAIPALLFLMLLYFVPETPRYLM 222


                 ....*.
gi 516061913 193 ARERHE 198
Cdd:PRK10077 223 SRGKQE 228

MFS_PLT

cd17437

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...

60-202

2.36e-08

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 55.49 E-value: 2.36e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17437   47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFP 126

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516061913 140 QAGYPFGYLLAGVV---YGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHESTAL 202
Cdd:cd17437  127 EIFINIGILLGYVSnyaFSGLPLHVGWRLMLGVGAVPSLFLAIGVLAMPESPRWTPAVRRMLIAAL 192

MFS_SLC22A7_OAT2

cd17447

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...

60-176

3.53e-08

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 54.74 E-value: 3.53e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17447   50 MGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLI 129

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 516061913 140 QAGYPFGYLLAGVVyglLYSVVGWRGMFVIGAVPVLL 176
Cdd:cd17447  130 SLFWTVGNMLLALV---AYLIRDWRWLILAVTLPCAP 163

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

36-184

5.43e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 5.43e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  36 IATSYHVDIKDVTLAILLTLAVRPIGALLFGR-AAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGG 114
Cdd:cd17474  225 LELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGL 304

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 115 VWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKV 184
Cdd:cd17474  305 NLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374

Sugar_tr

pfam00083

Sugar (and other) transporter;

250-392

5.50e-08

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 54.59 E-value: 5.50e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  250 SIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSL--PVLPLWAFAGGSWT-LGIGAFLMQFMVQGAWGVIPTYLT 326
Cdd:pfam00083  49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVigAVLQGAAKGKWSVYqLIVGRVLVGIGVGGASVLAPMYIS 128

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  327 ELVPANTRAVLpGFVYQL----GNLIASVNATLQAYIAESHGHNYGLAMAMVagtVAIVISVLVFFGRDT 392
Cdd:pfam00083 129 EIAPKKLRGAL-GSLYQLaitfGILLAYIFGLGLNKTSNSDGWRIPLGLQLV---PALLLIIGLLFLPES 194

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

36-388

6.49e-08

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.11 E-value: 6.49e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  36 IATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGV 115
Cdd:cd17474   25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 116 WGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLySVVGWRGMFVIGAVPVLLLPFIYFKVQESPVwLAARE 195
Cdd:cd17474  105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILFLLPEPK-EKAKS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 196 RHESTALLPVLKSHWKLCVYLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSE-RI 274
Cdd:cd17474  183 SSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRF 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 275 GRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAV---LPGFVYQLGNLIASV 351
Cdd:cd17474  263 GARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTassLYNFVRFLGQAVGPL 342

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 516061913 352 natLQAYIAESHGHNyglAMAMVAGTVAIVISVLVFF 388
Cdd:cd17474  343 ---LFGLLLEIFGLS---APFLVGAAIALAAAVLLAL 373

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

60-351

7.92e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 53.77 E-value: 7.92e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17329   50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 140 QAGYPFGYLLAGVVYGLLYsVVGWRGMFVIGAV-PVLLLPFIYFKVQESPVWLAARERHESTALLPVL---KSHWKLCVY 215
Cdd:cd17329  130 YWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVlFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVlrdRAFLLFLLA 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 216 LVVLMAAFNFFSHGtqdlYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWA 295
Cdd:cd17329  209 SFLISLIYFQLEST----LPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLA 284

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 516061913 296 FAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGF---VYQLGNLIASV 351
Cdd:cd17329  285 FANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFyalAWGLGRAIGPL 343

MFS_1

pfam07690

Major Facilitator Superfamily;

214-409

1.21e-07

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.19 E-value: 1.21e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  214 VYLVVLMAAFNFFSHGTqdLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPL 293
Cdd:pfam07690   1 LFLAAFLAALGRSLLGP--ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  294 WAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGhnYGLAMAM 373
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG--WRAAFLI 156

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 516061913  374 VAGTVAIVISVLVFFGRDTQGKVINAASNAKASDVG 409
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIV 192

2A0104

TIGR00881

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...

60-369

1.99e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 52.76 E-value: 1.99e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:TIGR00881  45 ISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFW 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  140 QAGYPF-GYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKV-QESPV--------WLAARERHESTALLPVLKSH 209
Cdd:TIGR00881 125 NCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLlRDSPQscglppaeEMPNEEPDGDAEKKEEELTK 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  210 WK-LCVYLV-----VLMAAFNFFSHGTQ----DLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKK- 278
Cdd:TIGR00881 205 KQiFLQYVLlnkvlWYISLGYVFVYVVRtgilDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRr 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  279 ---AIIIAALLSLPVLPLWAFAGGSWTL-GIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGNLIASVNAT 354
Cdd:TIGR00881 285 gplAVFFMALIIVSLLVYWLNPAANPLMdLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGL 364

                         330
                  ....*....|....*
gi 516061913  355 LQAYIAESHGHNYGL 369
Cdd:TIGR00881 365 PLGYLADGFGWAGAF 379

MFS_SLC17A9_like

cd17380

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...

66-190

4.21e-07

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 51.40 E-value: 4.21e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  66 GRAAEKFGRKPVLMVNILFFSFFELCT--AAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGY 143
Cdd:cd17380   55 GYLADRFGGKKVLLLAVALWSLATLLTplLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGS 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 516061913 144 PFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVqESPVW 190
Cdd:cd17380  135 YLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIY-LPPVW 180

MFS_GLUT6_8_Class3_like

cd17358

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...

257-344

4.43e-07

Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 51.81 E-value: 4.43e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 257 NIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAV 336
Cdd:cd17358   51 TLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGA 130


                 ....*...
gi 516061913 337 LpGFVYQL 344
Cdd:cd17358  131 L-GSLNQL 137

MFS_SVOPL

cd17442

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...

62-177

4.43e-07

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 51.73 E-value: 4.43e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  62 ALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGvamGGVWGVASSLAMET--IPDRSRGLMSGIF 139
Cdd:cd17442   53 SILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVG---CGVSGHSQGLIIKTefLPTKYRGYMLPLS 129

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 516061913 140 QAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLL 177
Cdd:cd17442  130 QIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIPGIIL 167

MFS_XylE_like

cd17359

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...

258-389

4.97e-07

Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 51.41 E-value: 4.97e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 258 IASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVL 337
Cdd:cd17359   47 LGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRL 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 516061913 338 PGFvYQL----GNLIASVNatlQAYIAESHGHNYGLAMA---MVAgtVAIVISVLVFFG 389
Cdd:cd17359  127 VSL-NQLmivfGQLLAYIV---NYLIANAGGADWLGAEGwrwMLG--LEAIPAILFLLG 179

MFS_YxlH_like

cd17490

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...

74-388

5.13e-07

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.45 E-value: 5.13e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  74 RKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAmGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVV 153
Cdd:cd17490   61 RKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLI 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 154 YGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVwLAARERHESTALLPVLKShwKLCVYLVVLMAAFNFFSHGTQDL 233
Cdd:cd17490  140 GGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERR-EKKPVLTELKELLSVLKD--KKLLFFSLLAILQQMITFSTTFG 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 234 YPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSE-RIGRKKAIIIAALLSLPVLPLWAFAGGSWTLgigaFLMQF 312
Cdd:cd17490  217 FTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYkKLGERNTIIIGFLLLGAYCFLIPFAPNLTLL----YLLQA 292

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 313 MVQGAWGVIPTYLTEL----VPANTRAVLPGF---VYQLGNLIASVnatLQAYIAEshghNYGLAMA-MVAGTVAIVISV 384
Cdd:cd17490  293 LNGFGTGILFPLLMSLsiegVPAEQRSTAMGFfqaIYALGMFLGPV---LVGIISE----AFGLQTGfFVIGVIALLAAI 365


                 ....
gi 516061913 385 LVFF 388
Cdd:cd17490  366 LSLA 369

MFS_MosC_like

cd17393

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...

35-310

5.95e-07

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 51.10 E-value: 5.95e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  35 DIATSYHVDIKDVTLAILltlaVRPIGALLF----GRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGV 110
Cdd:cd17393   24 AIKDRLGLSDAALGLLLL----ALGVGALVAmplaGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 111 AMGGVWGVASSLAMETIPDRSRGLMSGiFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPF-IYFKVQESPV 189
Cdd:cd17393  100 ANGALDVAMNAQGVAVERAYGRPIMSS-LHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAAlVAIRALLPGT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 190 WLAARERHESTALLPVLKSHWKLcvYLVVLMAAFNFFSHGT-QDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFG 268
Cdd:cd17393  179 GEAAEDRPDGAGKPGFLLPNRLL--LLLGLLALAAALAEGAaADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGD 256

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 516061913 269 TLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLM 310
Cdd:cd17393  257 RLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALM 298

MFS_GlpT

cd17345

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...

83-386

6.39e-07

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 51.09 E-value: 6.39e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  83 LFFSFFelcTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVG 162
Cdd:cd17345   83 ILIGFV---PSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFG 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 163 ---WRGMFVIGAVPVLLLPFIyfkvqespVWLAARERHESTALLP------------------------------VLKSH 209
Cdd:cd17345  160 dgwWRGAFIFPAIIAIIVAVI--------VLFLGKDTPESEGLPPieeykgdypeeadgeeeeqelsaweifvkyVLKNK 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 210 WklcVYLVVLMAAFNFF-SHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKK----AIIIAA 284
Cdd:cd17345  232 L---LWYIAIANVFVYLvRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRraptGIIFMI 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 285 LLSLPVLPLWaFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGNLIASVNAT-LQAYIAESH 363
Cdd:cd17345  309 LVIVALIVYW-LAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATaLIGIIVDHF 387

                        330       340
                 ....*....|....*....|...
gi 516061913 364 GHNYGLAMAMVAGTVAIVISVLV 386
Cdd:cd17345  388 GWNGGFIVLLASCILAIIFLALV 410

nepI

PRK10213

purine ribonucleoside efflux pump NepI;

50-294

9.03e-07

purine ribonucleoside efflux pump NepI;

Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 50.69 E-value: 9.03e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  50 AILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPD 129
Cdd:PRK10213  60 SVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPP 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 130 RSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHESTALLPVLKSH 209
Cdd:PRK10213 140 RTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVM 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 210 WKLCVYLVVLMAAFNFFSHgtqdLYPTFLKVQhGFDAHTVSIIAICYNIASIIgGVTFGTLSERIGRKKAIIIAALL--- 286
Cdd:PRK10213 220 AGMIAIFMSFAGQFAFFTY----IRPVYMNLA-GFGVDGLTLVLLSFGIASFV-GTSLSSFILKRSVKLALAGAPLVlav 293


                 ....*...
gi 516061913 287 SLPVLPLW 294
Cdd:PRK10213 294 SALVLTLW 301

MFS_SLC17

cd17318

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...

63-190

1.50e-06

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 49.92 E-value: 1.50e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  63 LLFGRAAEKFGRKPVLMVNILFFSFFELCT--AAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQ 140
Cdd:cd17318   74 IPGGYLAEKYGAKRVLGYSILITALLTLLTplAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAY 153

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 516061913 141 AGYPFGYLLAGVVYGLLYSVVGWRGMF-VIGAVPVLLLPFIYFKVQesPVW 190
Cdd:cd17318  154 SGSQFGTVIAMPLSGFLCESLGWPSIFyIFGGLGLLWCLLWFFLVL--PVW 202

PRK15075

tricarballylate/proton symporter TcuC;

50-340

1.81e-06

tricarballylate/proton symporter TcuC;

Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 49.94 E-value: 1.81e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  50 AILLTLAV-------RPIGALLFGRAAEKFGRKPVLMVN----------ILFFSFFELCTAAAPSLTvfLILRVIYGVAM 112
Cdd:PRK15075  54 SLMLTFAVfgagflmRPLGAIVLGAYIDRVGRRKGLIVTlsimasgtllIAFVPGYATIGLAAPLLV--LLGRLLQGFSA 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 113 GGVWGVASSLAMETIPDRSRGLM----SGIFQAGYPF----GYLLAGVVYGLLYSVVGWRGMFVIGAvpvLLLPFIYF-- 182
Cdd:PRK15075 132 GVELGGVSVYLAEIATPGRKGFYtswqSASQQVAVVFaallGYLLNQWLSPAQMAEWGWRIPFLIGC---LIVPFIFLir 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 183 -KVQESPVWLAARERHESTALLPVLKSHWKLCV--YLVVLM--AAFNFFSHGTqdlyPTFLKVQHGFDAHTVSIIAICYN 257
Cdd:PRK15075 209 rSLEETEEFLARKHRPSMREIFRSLAANWRIVLagMLMVAMttVSFYLITVYT----PTFGKTVLHLSAADSLLVTLCVG 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 258 IASIIGGVTFGTLSERIGRKKAIIIAALLSL----PVLpLWAFAGGSWTLGIGAFLMQFMVQGAW-GVIPTYLTELVPAN 332
Cdd:PRK15075 285 VSNFIWLPIGGALSDRIGRRPVLIAFTVLAIltayPAL-SWLVAAPSFARMLAVELWLSFLYGSYnGAMVVALTEVMPAE 363


                 ....*...
gi 516061913 333 TRAVlpGF 340
Cdd:PRK15075 364 VRTA--GF 369

MFS_YcxA_like

cd17355

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...

36-388

2.53e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 49.19 E-value: 2.53e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  36 IATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILrviYGVAMGGV 115
Cdd:cd17355   29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLL---WGLLGGGG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 116 WGVASSLAMETI----PDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGA-------VPVLLLPFIYFKV 184
Cdd:cd17355  106 AGTLAAVAFATVaawwFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLAllallvlVPVLLLLRRRPAD 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 185 QESPVWLAARERHESTALLPVLKSHWKLCVYLVVLMAAFNffSHGTQDLYPTFLkVQHGFDAHTVSIIAICYNIASIIGG 264
Cdd:cd17355  186 LALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFA--VVGLIVHLVPYL-ADRGISPAAAAVALALIGLFNIVGR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 265 VTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLT-ELVPANTRAVLPGFVYQ 343
Cdd:cd17355  263 LLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAaRYFGARSYGTLFGLVFA 342

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 516061913 344 LGNLIASVNATLQAYIAeSHGHNYGLAMAMVAGTVAIVISVLVFF 388
Cdd:cd17355  343 PHQLGSALGPWLGGLLY-DRTGSYTAAWALAVALGLIAALLVLPI 386

MFS_TetA

cd17388

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...

60-388

2.78e-06

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 49.17 E-value: 2.78e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVaMGGVWGVASSLAMETIPDRSR----GLM 135
Cdd:cd17388   53 IFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQRarnfGLL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 136 SGIFQAGYPFGYLLAGVVYGllysvVGWRGMFVIGAVPVLL-LPFIYFKVQESpvWLAARERHESTALLPVLKSHWKLCV 214
Cdd:cd17388  132 GAAFGLGFIAGPALGGLLGE-----ISPRAPFLVAAGLNGLnFLLGLFVLPES--LPPERRRAFRWRRANPFGSLRWLTG 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 215 YLVV--LMAAFNFFS---HGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASII--GGVTfGTLSERIGRKKAIIIAALLS 287
Cdd:cd17388  205 FPGLlgLLAVFFLIQligQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALfqAFVT-GPIAKRLGEKRAILLGLAAD 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 288 LPVLPLWAFAGGSWtlgigaFLMQFMVQGAWGVIPT-----YLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYI-AE 361
Cdd:cd17388  284 ALGFLLLAFATQGW------MVFPILILLALGGIAGpalqgLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIfAA 357

                        330       340
                 ....*....|....*....|....*..
gi 516061913 362 SHGHNYGLAMAMVAGTVAIVISVLVFF 388
Cdd:cd17388  358 SPATWPGLAWIIGAALYLICLVLAYRF 384

efflux_Bcr_CflA

TIGR00710

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...

36-389

5.09e-06

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.

Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 48.15 E-value: 5.09e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   36 IATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGV 115
Cdd:TIGR00710  31 IAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  116 WGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMF-VIGAVPVLLLPFIYFKVQESpvwLAAR 194
Cdd:TIGR00710 111 SVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFaFLSLAGILLSALIFFILPET---LPYE 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  195 ERHESTALLPVLKSHWK-LCVYLVVLMAA------FNFFSHGtqdlyPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTF 267
Cdd:TIGR00710 188 ARIQISTYFETFLLLLKsKMFWGYALIYGasfggfFAFFSGA-----PFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLN 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  268 GTLSERIGRKKAIIIA-ALLSLPVLPLWA---FAGGSWTLGIG-AFLMQFMVQGAWGVIPTYLTELVP--ANTRAVLPGF 340
Cdd:TIGR00710 263 GRFIKKWGAKSLLRMGlILFAVSAVLLEItaiLGLGSWAMIIGpMMFVGIGNSMISSIAMAYALEDFPhvAGTASALFGT 342

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 516061913  341 VYqlGNLIASVnATLQAYIAESHGHNYGLAMAMVAgtvaiVISVLVFFG 389
Cdd:TIGR00710 343 LR--LVLGAIV-GYLVSLIHGNTAWPMSLSCLVLA-----VVSVLAFYY 383

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

236-406

7.45e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.57 E-value: 7.45e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 236 TFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQ 315
Cdd:COG2223   29 PPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGG 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 316 GAWGVIPTYLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGHNYglAMAMVAGTVAIVISVLVFFGRDTQGK 395
Cdd:COG2223  109 GSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN--AFLILGILLLVVAVLAWLFLRDPPAG 186

                        170
                 ....*....|.
gi 516061913 396 VINAASNAKAS 406
Cdd:COG2223  187 AAAAAKASLRD 197

MFS_MelB_like

cd17332

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...

130-329

1.53e-05

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 46.83 E-value: 1.53e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 130 RSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWR--------GMFVIGAVPVLLLPFIYFKVQESPVwlAARERHESTA 201
Cdd:cd17332  132 EERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGnasrgyflTALIIGIIGIILLLICFFGTRERVV--PPEEEKSKLP 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 202 LLPVLKSHWK----LCVYLVVLMAAFNFFSHGTqdLYPTFLKVQHGFDAHTVSIIAIcYNIASIIGGVTFGTLSERIGRK 277
Cdd:cd17332  210 LLKSLKALLKnrpfLILLLAYLLYFLAFNIVNT--VLVYYFKYVLGGRAELVLLLLL-ILSGALLALLPWPPLKKRFGKK 286

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 516061913 278 KAIIIAALLSLPVLPLWAFAGGS--WTLGIGAFLMQFMVQGAWGVIPTYLTELV 329
Cdd:cd17332  287 KAFFIGLLLAILGLLLLFFLPPGnlVLILVLAVLAGIGYGGANLLPWAMLADVI 340

MFS_STP

cd17361

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...

60-189

2.16e-05

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 46.47 E-value: 2.16e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17361   66 VASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGF 145

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 516061913 140 QAGYPFGYLLAGVV-YGLLYSVV-GWRGMFVIGAVPVLLLPFIYFKVQESPV 189
Cdd:cd17361  146 QLAITIGILIANLInYGTSKIKPnGWRLSLGLAAVPALILLLGSLFLPETPN 197

MFS_GLUT_Class1_2_like

cd17357

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...

250-387

2.54e-05

Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 46.10 E-value: 2.54e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 250 SIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSL--PVLPLWAFAGGSW-TLGIGAFLMQFMVQGAWGVIPTYLT 326
Cdd:cd17357   52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVvsSLLMFLSKSAKSPeLLIFGRFLVGIACGLSTGFVPMYLQ 131

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516061913 327 ELVPANTR---AVLPGFVYQLGNLIASVNATLQAYIAESHGHnYGLAMAMVAGTVAIVISVLVF 387
Cdd:cd17357  132 EISPSELRgalGSLTQIGVTLGILLGQVFGLPSVLGTETLWP-YLLFFPGIPALLQLAALPFFP 194

MFS_SLC22A15

cd17377

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...

60-127

2.86e-05

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 45.92 E-value: 2.86e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETI 127
Cdd:cd17377   54 IGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECV 121

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

217-395

7.14e-05

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.72 E-value: 7.14e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 217 VVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAF 296
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 297 AGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGHNYGLAMAMVAG 376
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160

                        170
                 ....*....|....*....
gi 516061913 377 TVAIVISVLVFFGRDTQGK 395
Cdd:cd06174  161 LALLAAILLLLVVPDPPES 179

MFS_YxlH_like

cd17490

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...

60-176

7.44e-05

Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.52 E-value: 7.44e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFG-RAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGI 138
Cdd:cd17490  245 LASLLSGtLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGF 324

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 516061913 139 FQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLL 176
Cdd:cd17490  325 FQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALL 362

MFS_PhT

cd17364

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...

60-183

9.31e-05

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 44.19 E-value: 9.31e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPV------LMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRG 133
Cdd:cd17364   54 IGQLFFGFLGDRFGRKRVygveliIMIIGTILSALSPGSTPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRG 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516061913 134 LMSGIFQAGYPFGYLLAGVVYGLLYSVVG--------------WRGMFVIGAVPVLLLpfIYFK 183
Cdd:cd17364  134 ALIAAVFAMQGFGILAGAIVTLILSAIFEhplpagtyhhadlvWRIVLGLGAIPALSV--LYFR 195

MFS_OCT_plant

cd17378

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...

60-180

1.01e-04

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 43.89 E-value: 1.01e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAE-KFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGI 138
Cdd:cd17378   48 IGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQVGMS 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 516061913 139 FQAGYPFGYL-LAGVVYGLLYSvvgWRGMFVIGAVP-----VLLLPFI 180
Cdd:cd17378  128 TFFFFVLGFMsLPGIAYLNGSS---WRVLYFWTSIPaliycILVYLFA 172

MFS_MCT_SLC16

cd17352

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...

11-390

1.07e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 44.08 E-value: 1.07e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  11 VAIASFLSWTLDAFDFFLLVFLLSDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFEL 90
Cdd:cd17352    4 VVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  91 CTAAAPSLTVFLIlrvIYGVAMGGVWGVASSLAMETIP---DRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMF 167
Cdd:cd17352   84 LSSFATSLWQLYL---TYGVLGGLGLGLIYSPAIVIVGqyfEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 168 VIGAVPVLLLPFIyfkvqespvwlaarerhesTALLPVLKSHWKLCVYLVVLMAAFNFFSHGTqdLYPTFLKvQHGFDAH 247
Cdd:cd17352  161 LILGGLCLNLCVC-------------------GLLLRLLKDPTFVLLALGVSFAMLGFFVPFV--YLPSYAK-SLGIDES 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 248 TVSIIAICYNIASIIGGVTFGTLSER--IGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYL 325
Cdd:cd17352  219 DAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVIL 298

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516061913 326 TELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGhNYgLAMAMVAGTVAIVISVLVFFGR 390
Cdd:cd17352  299 ADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTG-DY-DAAFYFCGACLLLSGVLLFLLP 361

MFS_ShiA_like

cd17369

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...

42-155

1.20e-04

Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.05 E-value: 1.20e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  42 VDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILF-----FSFFELCTAAAPSLTVFLILrVIYGVAMGGVW 116
Cdd:cd17369  261 VDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLaalfaFPFFWLLDTGSTWLIVLAAV-VVLGVLHGMMY 339

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 516061913 117 GVASSLAMETIPDRSRglmsgifQAGYPFGYLLAGVVYG 155
Cdd:cd17369  340 GPQAAFLAELFPTRVR-------YTGASLGYQLGAILGG 371

MFS_GLUT_like

cd17315

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...

243-351

1.69e-04

Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 43.33 E-value: 1.69e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 243 GFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIP 322
Cdd:cd17315   30 GLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVP 109

                         90       100       110
                 ....*....|....*....|....*....|..
gi 516061913 323 TYLTELVPANTR---AVLPGFVYQLGNLIASV 351
Cdd:cd17315  110 LYISEIAPAKIRgalGTLNQLMITFGILLAYL 141

MFS_TRI12_like

cd06179

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...

47-182

2.15e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.38 E-value: 2.15e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  47 VTLAILLTLAVrpiGALLFGRAAEKFGRKPVLMV-NILFFSFFELCtAAAPSLTVFLILRVIYGVAMGGVwGVASSLAME 125
Cdd:cd06179   37 ISTAWSLAQAV---LGPIVGRLSDLFGRRWFFIGgNLLGVVGSIVA-GTAKSVNMLIGGQALIGIGAGTQ-GLGAAVASE 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516061913 126 TIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLL--YSVVGWRGMF----VIGAVPVLLLPFIYF 182
Cdd:cd06179  112 LVPNKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFyinaIFNALALILLFFFYH 174

MFS_YxiO_like

cd17482

Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ...

47-172

2.20e-04

Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 42.98 E-value: 2.20e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  47 VTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMET 126
Cdd:cd17482  226 LILALLLTQFVAFPGALLFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAALIGLVQGGIQALSRSLFGRL 305

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 516061913 127 IPDRSRGLMSGIF----QAGYPFGYLLAGVVYGLL----YSVVGWRGMFVIGAV 172
Cdd:cd17482  306 IPKGKSAEFFGFYnisgKFAAIIGPLLFGLITQLTgssrYGILSLIVLFVIGGI 359

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

261-387

2.41e-04

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.96 E-value: 2.41e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 261 IIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGF 340
Cdd:cd17365   48 AIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTL 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 516061913 341 VYQLGNLIASVNATLQAYIAESHGHNyglAMAMVAGTVAIVISVLVF 387
Cdd:cd17365  128 MFCGYPLGAALGGFLAAALIPAFGWR---SVFLLGGVPPLILLPLLR 171

synapt_SV2

TIGR01299

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...

60-198

2.53e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.

Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 43.43 E-value: 2.53e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRG------ 133
Cdd:TIGR01299 217 VGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGehlswl 296

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516061913  134 ----LMSGIFQAGYP------FGYLLAgvvYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHE 198
Cdd:TIGR01299 297 cmfwMIGGIYAAAMAwaiiphYGWSFQ---MGSAYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHD 368

emrD

PRK11652

multidrug transporter EmrD;

35-223

2.60e-04

multidrug transporter EmrD;

Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 42.97 E-value: 2.60e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  35 DIATSYHVD---IKDVTLAILLTLAvrpIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGva 111
Cdd:PRK11652  33 DMARDLNVRegaVQAVMAAYLLTYG---LSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQG-- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 112 MG-GVWGVASslamETIPdrsRGLMSG--------IFQAGYPFGYLLAGVVYGLLYSVVGWRG----MFVIGAVpVLLLP 178
Cdd:PRK11652 108 LGtGVGGVMA----RTLP---RDLYEGtqlrhansLLNMGILVSPLLAPLIGGLLTTLFGWRAcylfLLLLGAG-VTFSM 179

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 516061913 179 FIYFKvqESPVwlAARERHESTALLPVLKSHWKLCVYLVVLMAAF 223
Cdd:PRK11652 180 ARWMP--ETRP--ADARRTRVLASYRTLLSNRRFNCYLLMLIGTL 220

MFS_FEN2_like

cd17327

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...

71-350

2.71e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 43.01 E-value: 2.71e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  71 KFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWgVASSLAMETIPDRS-RGLMSGIFQAGYPFGYLL 149
Cdd:cd17327   67 RFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVF-PGFILYLGMWYKREeQAKRIAFFYAAAGLGSIF 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 150 AGVV-YGLLY-----SVVGWRGMFVI-GAVPVLLLPFIYFKVQESPV---WLAARERH-------ESTALLPVLKSHWK- 211
Cdd:cd17327  146 GGLLaYGVFKilgvgGLAGWRWLFIIeGLITIIIGLVIFFWLPDNPSkawFLTEEEKElaverlrANQTGKGDQKFKWKq 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 212 ----LCVYLVVLMAAFNFFSHGTQDLYPTFLKV---QHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKK-AIIIA 283
Cdd:cd17327  226 ikeaFKDPRTWLLFLFFFCSQITNNGISNFLPLilkSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGlFAIFA 305

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516061913 284 ALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANT-RAVLPG---FVYQLGNLIAS 350
Cdd:cd17327  306 CVLALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTkRATVLAimlIFYNVGNIVAP 376

MFS_GLUT8_Class3

cd17433

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...

60-207

2.81e-04

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 42.94 E-value: 2.81e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17433   56 AGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCV 135

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516061913 140 QAGYPFGYLLAgVVYGLlysVVGWRGMFVIGAV-PVLLLPFIYFKVQESPVWLAARERHESTALLPVLK 207
Cdd:cd17433  136 QLMVVIGIMGA-YLAGL---VLDWRWLAVLGSIpPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLR 200

MFS_Amf1_MDR_like

cd17476

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...

63-171

2.99e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 42.63 E-value: 2.99e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  63 LLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVwgVASSLAMETI---PDRSRGLMSGIF 139
Cdd:cd17476   51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFL--LPNAMALLGRtypPGPRKNIVFSLF 128

                         90       100       110
                 ....*....|....*....|....*....|..
gi 516061913 140 QAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGA 171
Cdd:cd17476  129 GATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160

MFS_Set

cd17471

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...

63-176

3.02e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 3.02e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  63 LLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSrGLMSGIFQAG 142
Cdd:cd17471  253 LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQP-GLATTLYSNA 331

                         90       100       110
                 ....*....|....*....|....*....|....
gi 516061913 143 YPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLL 176
Cdd:cd17471  332 SRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALL 365

xylE

PRK10077

D-xylose transporter XylE; Provisional

258-340

3.91e-04

D-xylose transporter XylE; Provisional

Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 42.37 E-value: 3.91e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 258 IASIIGGVTFGTLSERIGRKKAIIIAALL--------SLPVLPLWAFAGGSWTLGIgAFLMQFMVQG-----AWGVIPTY 324
Cdd:PRK10077  66 IGCIIGGALGGYCSNRFGRRDSLKIAAVLffisalgsAWPEFGFTSIGPDNTGYVP-EFVIYRIIGGigvglASMLSPMY 144

                         90
                 ....*....|....*.
gi 516061913 325 LTELVPANTRAVLPGF 340
Cdd:PRK10077 145 IAEIAPAHIRGKLVSF 160

MFS_FucP_MFSD4_like

cd17333

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...

35-288

4.09e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.31 E-value: 4.09e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  35 DIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGG 114
Cdd:cd17333   21 SLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 115 VWGVASSLAMETIPDRSRGLMS---GIFQAGYPFGYLLAGVvygLLYSVVGWRGMF-VIGAVPVLLLPFIYFKVQESPVW 190
Cdd:cd17333  101 LDTGANTFVGALFEESSATRLNvlhGFFGLGALIGPLIATS---LLTSELSWSWAYlIIGLIYLLLAILILLTLFPELPS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 191 LAARERHESTALLPVLKSHWKLCVYLVVLMAAFNFFSHGTQDLY-PTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGT 269
Cdd:cd17333  178 ARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWvPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGP 257

                        250
                 ....*....|....*....
gi 516061913 270 LSERIGRKKAIIIAALLSL 288
Cdd:cd17333  258 ISRRIKPHTLLVLSGSGAL 276

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

63-185

4.44e-04

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.21 E-value: 4.44e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  63 LLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQAG 142
Cdd:cd17329  254 FPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALA 333

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 516061913 143 YPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQ 185
Cdd:cd17329  334 WGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376

PRK11043

Bcr/CflA family multidrug efflux MFS transporter;

60-297

4.97e-04

Bcr/CflA family multidrug efflux MFS transporter;

Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.19 E-value: 4.97e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVI--YGVAMGGV-WgvaSSLAMETIP-DRSRGLM 135
Cdd:PRK11043  56 LGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVqaVGVCSAAViW---QALVIDRYPaQKANRVF 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 136 SGIFqagyPFGYL---LAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVwlAARERHESTALLPVLKSHwkl 212
Cdd:PRK11043 133 ATIM----PLVALspaLAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKK--ARKQSQDALTFKQLLKSK--- 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 213 cVYL--VVLMAAFN--FFSHGTqdLYPTFLKvQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAI-IIAALLS 287
Cdd:PRK11043 204 -TYLgnVLIFAACSaaFFAWLT--GSPFILE-QMGYSPADIGLSYVPQTIAFLVGGYGCRAALQKWGGEQLLpWLLVLFA 279

                        250
                 ....*....|
gi 516061913 288 LPVLPLWAFA 297
Cdd:PRK11043 280 VSVIAIWLAS 289

MFS_HXT

cd17356

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...

241-344

6.42e-04

Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 41.85 E-value: 6.42e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 241 QHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWT-LGIGAFLMQFMVQGAWG 319
Cdd:cd17356   39 TYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYqLIVGRIIAGLGVGFASV 118

                         90       100
                 ....*....|....*....|....*
gi 516061913 320 VIPTYLTELVPANTRAVLPGfVYQL 344
Cdd:cd17356  119 LVPVYQSEVAPKHIRGTLVS-LYQL 142

MFS_HMIT_like

cd17360

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...

259-337

6.47e-04

Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 41.49 E-value: 6.47e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516061913 259 ASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVL 337
Cdd:cd17360   47 GAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRL 125

PRK03545

putative arabinose transporter; Provisional

34-309

6.59e-04

putative arabinose transporter; Provisional

Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 41.80 E-value: 6.59e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  34 SDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMG 113
Cdd:PRK03545  33 SDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAHA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 114 GVWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLaGVVYG-LLYSVVGWRGMF-VIGAVPVLLLPFIYFKVQESPvwl 191
Cdd:PRK03545 113 IFWSITASLAIRVAPAGKKAQALSLLATGTALAMVL-GLPLGrVIGQYLGWRTTFlAIGGGALITLLLLIKLLPLLP--- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 192 aaRERHESTALLPVL-KSHWKLCVYL---VVLMAAFNFFSHgtqdLYPtFLKVQHGFDAHTVSIIAICYNIASIIGGVTF 267
Cdd:PRK03545 189 --SEHSGSLKSLPLLfRRPALVSLYLltvVVVTAHFTAYSY----IEP-FVQQVAGLSENFATLLLLLFGGAGIIGSVLF 261

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 516061913 268 GTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFL 309
Cdd:PRK03545 262 SRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIF 303

MFS_SLC22A17

cd17445

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...

61-176

8.65e-04

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 41.30 E-value: 8.65e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  61 GALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWgVASSLAMETIPDRSRGLM----S 136
Cdd:cd17445   52 GYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVY-LTLYLTRLELCDPPQRLLvamaG 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 516061913 137 GIFQAGYPFGYLlagvvyGLLYSVVGWRGMFVIGAVPVLL 176
Cdd:cd17445  131 GLTMVGGHFLLL------GLALGCGSWRVLQGTITAPLSL 164

BtlA

COG2270

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...

47-388

1.19e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];

Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.91 E-value: 1.19e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  47 VTLAILLTLAVRPIgallFGRAAEKFGRKPVLMVnilFFSFfeLCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAM-- 124
Cdd:COG2270   58 LAIAGLLVALLAPV----LGAIADRSGRKKPFLA---FFTL--LGVLATAALFFVAPGGLWLGLLLFVLANIGFEGSLvf 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 125 ------ETIPDRSRGLMSGIfqaGYPFGYLLAGVVYGLLYSVVGW-------------RGMFVIGAVPVLL--LPFIYFk 183
Cdd:COG2270  129 ynaflpDIATPEEIGRVSGL---GWALGYLGGVLLLLINLALFLKpeafglpdageavRISFLLTALWWLLfaLPLFLF- 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 184 VQESPVWLAARERHESTALLPVLKSHWK-LCVY--LVVLMAAFNFFSHGTQDLYP---TFLKVQHGFDAHTVSIIAICYN 257
Cdd:COG2270  205 LPERPRPGPAPPRGAVRAGFRELRRTLReLRRYrdLLRFLLAYFFYRDGVQTVIAfagIYAAGVLGFSTTELIVFGLLVQ 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 258 IASIIGGVTFGTLSERIGRKKAIIIaALLSLPVLPLWA-FAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAV 336
Cdd:COG2270  285 IVAALGALLFGRLDDRIGPKRVILV-SLVIWIVVCLAAyFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAE 363

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 516061913 337 LPGFvYQLGNLIASVNATLQayiaeshghnYGLAMAMVAGTVAIVISVLVFF 388
Cdd:COG2270  364 FFGL-YALSGKAASFLGPLL----------FGLVTQLTGSQRLGILSLIVFF 404

2A0119

TIGR00898

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

255-348

1.19e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.15 E-value: 1.19e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  255 CYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTR 334
Cdd:TIGR00898 135 CFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQR 214

                          90
                  ....*....|....*..
gi 516061913  335 A---VLPGFVYQLGNLI 348
Cdd:TIGR00898 215 AivgTLIQVFFSLGLVL 231

MFS_SLC22A18

cd17331

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...

60-384

1.28e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.67 E-value: 1.28e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRvIYGVAMGGVWGVASSLAMETIPD-RSRGLmsGI 138
Cdd:cd17331   50 VGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR-LPSVFMHAMQAAQMVVTDLTDPGeRAAAL--GR 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 139 FQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHESTALLPVLKSHWKLCV---- 214
Cdd:cd17331  127 LGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRllrl 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 215 ----YLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASII-GGVTFGTLSERIGRKKAIIIAALLSLP 289
Cdd:cd17331  207 pgvaFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVvQGLLVGPLTKRFGERSLLKLSVALLAI 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 290 VLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGFVYQLGNLIASVNATLQAYIAESHGH-NYG 368
Cdd:cd17331  287 GYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFpSFG 366

                        330
                 ....*....|....*.
gi 516061913 369 LAMAMVAGTVAIVISV 384
Cdd:cd17331  367 LLGAAINGLLTVYLLL 382

MFS_AmpG_like

cd17486

AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ...

118-291

1.31e-03

AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 40.66 E-value: 1.31e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 118 VASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERH 197
Cdd:cd17486  111 AIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSLSWSAVYLIMAALMGPGILATLFAPEPPRTDPPANSL 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 198 ESTALLPV----LKSHWKLCVYLVVLMAAFNFfshgtQDLYPT-----FLkVQHGFDAHTVSIIAICYNI-ASIIGGVTF 267
Cdd:cd17486  191 SETVVAFFapfkDFFGQPGALLILAFILLYKL-----GDAMLGamatpFL-LDLGFTKTEIGAVYKTVGLiATIVGGLLG 264

                        170       180
                 ....*....|....*....|....*
gi 516061913 268 GTLSERIGRKKAI-IIAALLSLPVL 291
Cdd:cd17486  265 GFLMSRLGLKRSLwLFGILQALSNL 289

MFS_NRT2_like

cd17341

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...

13-307

1.38e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.70 E-value: 1.38e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  13 IASFLSWTLDAFDFFLlvfllsdIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFFEL-C 91
Cdd:cd17341    9 FLGFMVWFLFAPLGPV-------IRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLaL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  92 TAAAPSLTVFLILRVIYGVAmGGVWGVASSLAMETIPDRSRGLMSGIF----QAGYPFGYLLAGVVYG---LLYSVVGWR 164
Cdd:cd17341   82 ALAVSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIagagNMGVAVSQLLAPLIAGaivFDGGFVGWR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 165 GMFVIGAVPVLLLPFIYFKVQESPVWLAARERHESTALLPVLKSH--WKLCVYLVVLMAAFNFFSHGTqdlyPTFLKVQH 242
Cdd:cd17341  161 NAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAVLKNYrtWILSLLYGVTFGSFVGFSNVL----PTYFKTRF 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516061913 243 GFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKK------------AIIIAALLSLPVLPLWAFAGGSWTLGIGA 307
Cdd:cd17341  237 GLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRrlwwlfivmtigAALLSLSLPTSGTNLVLFLALFVALGLGA 313

MFS_GLUT_Class1

cd17431

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...

249-349

1.87e-03

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 40.40 E-value: 1.87e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 249 VSIIAIcyniASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFA--GGSWTLGI-GAFLMQFMVQGAWGVIPTYL 325
Cdd:cd17431   56 VAIFSV----GGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSklAKSYEMLIlGRFIIGLYCGLTTGLVPMYI 131

                         90       100
                 ....*....|....*....|....
gi 516061913 326 TELVPANTRAVLpGFVYQLGNLIA 349
Cdd:cd17431  132 GEISPTALRGAL-GTLHQLGIVVG 154

MFS_SV2B

cd17438

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...

60-198

1.98e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 40.29 E-value: 1.98e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRG------ 133
Cdd:cd17438   49 AGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGehlswl 128

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516061913 134 ----LMSGIFQAGYPFGYLLA---GVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHE 198
Cdd:cd17438  129 cmfwMIGGLYASAMAWSIIPHygwGFSMGTNYHFHSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHD 200

MFS_FBT

cd17484

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...

74-290

2.01e-03

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 40.29 E-value: 2.01e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  74 RKPVLMV----NILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVwgVASSLAMET---IPDRSRGLMSGIFQAGYPFG 146
Cdd:cd17484   66 RKPYLILagalGALSWLALALVSNSSLALALLLLLLASLGVAFSDV--VIDALVVEAsrgAPQSLAGDLQSLCWGSSAIG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 147 YLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHESTALlpvlKSHWKLCVYLVVLM-AAFNF 225
Cdd:cd17484  144 GIVGSYFSGYLLELLGPRTVFAVTSFFPLLLLIVAFFVKEERVPPHRTKENFDEQL----KALWETVKQPSIWLpALFIF 219

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516061913 226 FSHGTQDLYPTFLKVQH---GFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPV 290
Cdd:cd17484  220 LYQATPSSGSAMFYFMTnelGFSPEFLGRLRVIGSIASLLGVLLYNRFLKHVPFRKIFFWTTVLLVLL 287

PRK15402

MdfA family multidrug efflux MFS transporter;

62-172

2.10e-03

MdfA family multidrug efflux MFS transporter;

Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 39.92 E-value: 2.10e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  62 ALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPD----RSRGLMSG 137
Cdd:PRK15402  65 QWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEadaiKITALMAN 144

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 516061913 138 IFQagypFGYLLAGVVYGLLYSVVGWRGMFVIGAV 172
Cdd:PRK15402 145 VAL----LAPLLGPLVGAALIHVLPWRGMFVLFAA 175

MFS_GLUT6_Class3

cd17434

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...

215-337

2.22e-03

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 40.20 E-value: 2.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 215 YLVVLMAAFNFFSHGTQDLYP--------TFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALL 286
Cdd:cd17434    1 FLAVFSAVLGNFSFGYALVYTspvipaleQGDDPRLHLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVP 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 516061913 287 SLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVL 337
Cdd:cd17434   81 SALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGAL 131

MFS_SLC22

cd17317

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...

249-345

2.24e-03

Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.87 E-value: 2.24e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 249 VSIIAICYNIASIIGGVTFGTLSERIGRKKAIIIAALLSLPVLPLWAFAGGSWTLGIGAFLMQFMVQGAWGVIPTYLTEL 328
Cdd:cd17317   27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106

                         90       100
                 ....*....|....*....|
gi 516061913 329 VPANTR---AVLPGFVYQLG 345
Cdd:cd17317  107 VGPKYRsfvGILFGLFWALG 126

2A0109

TIGR00887

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...

58-153

2.33e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]

Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 40.10 E-value: 2.33e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   58 RPIGALLFGRAAEKFGRKPVL---MVNILFFSFFELCTAAAPSLTVFLIL---RVIYGVAMGGVWGVASSLAMETIPDRS 131
Cdd:TIGR00887  69 TLAGQLFFGWLADKLGRKRVYgmeLIIMIIATVASGLSPGSSPKSVMATLcfwRFWLGVGIGGDYPLSAIITSEFATKKW 148

                          90       100
                  ....*....|....*....|..
gi 516061913  132 RGLMSGIFQAGYPFGYLLAGVV 153
Cdd:TIGR00887 149 RGAMMAAVFAMQGFGILAGAIV 170

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

9-152

2.63e-03

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 2.63e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913   9 RNVAIASFLSWTLDAFDFFLLVFLLSDIATSYHVDIKDVTLAILLTLAVRPIGALLFGRAAEKFGRKPVLMVNILFFSFF 88
Cdd:cd17316  177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516061913  89 E--LCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIfqaGYPFGYLLAGV 152
Cdd:cd17316  257 AlpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGL---SYNLGRLGGGG 319

PRK10473

MdtL family multidrug efflux MFS transporter;

63-132

2.86e-03

MdtL family multidrug efflux MFS transporter;

Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 39.62 E-value: 2.86e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  63 LLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSR 132
Cdd:PRK10473  56 LFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRR 125

MFS_MFSD10

cd17389

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...

64-146

3.04e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 39.56 E-value: 3.04e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  64 LFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVwgvasSLAMETIPD------RSRGL-MS 136
Cdd:cd17389   83 ITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNV-----SLSTAIVADvtspkkRSKGMaLI 157

                         90
                 ....*....|.
gi 516061913 137 GI-FQAGYPFG 146
Cdd:cd17389  158 GVaFSLGFIIG 168

UNC-93

pfam05978

Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 ...

156-288

3.07e-03

Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons.

Pssm-ID: 461792 [Multi-domain] Cd Length: 379 Bit Score: 39.61 E-value: 3.07e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  156 LLYSVvgWRGMFVIGAVPVLLLPfiyfkvqESPVWLAARERHESTALLPVLKSHWKLCVYLVVLMAAFNFFSHGTQ---- 231
Cdd:pfam05978 136 LLYSV--FTAISIVGIVVFAFLP-------SPDYENVLSSKEKIQSFADQFKSTFRLLRTPKMLLLAVFFFYTGLEvsfw 206

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516061913  232 -DLYPTFLKVQHGFDAHTVSIIAI---CYNIASIIGGVTFGTLSERI---GRKKAIIIAALLSL 288
Cdd:pfam05978 207 tSIYPTCISFTSKLGTNTTYLIAIysiSTGLGQIIGGIFFGPLGKRIrkfGRDPTILLGTLLHL 270

MFS_SLC22A4_5_OCTN1_2

cd17376

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...

60-176

3.26e-03

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 39.37 E-value: 3.26e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMS--G 137
Cdd:cd17376   50 LGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVRILFStlG 129

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 516061913 138 IFqAGYPFGYLLAGVVyglLYSVVGWRGMFVIGAVPVLL 176
Cdd:cd17376  130 VC-IFYAIGYMLLPLF---AYFIRDWRMLLLALTLPGVL 164

MFS_SLC22A23

cd17444

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...

60-132

3.39e-03

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341002 [Multi-domain] Cd Length: 364 Bit Score: 39.45 E-value: 3.39e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSR 132
Cdd:cd17444   51 FGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHR 123

MFS_SLC22A17_like

cd17373

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...

61-179

4.81e-03

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340931 [Multi-domain] Cd Length: 348 Bit Score: 38.65 E-value: 4.81e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  61 GALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSR---GLMSG 137
Cdd:cd17373   41 GYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTLYLLRLELCDPGKRlmiTMVAS 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 516061913 138 IFQAGYPFGYLlagvvyGLLYSVVGWRGMFVIGAVPVLLLPF 179
Cdd:cd17373  121 LVAVAGQFLMP------GLAALCRDWRVLQALIICPFLLMLL 156

MFS_MdtG_MDR_like

cd17391

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...

60-185

6.41e-03

Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.40 E-value: 6.41e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIF 139
Cdd:cd17391  255 LSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYN 334

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 516061913 140 QAGYPFGYLLAGVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQ 185
Cdd:cd17391  335 QSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380

MFS_GLUT_Class2

cd17432

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...

42-202

7.45e-03

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 38.37 E-value: 7.45e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  42 VDIKDVTLAILLTLAVRPIG----ALLFGRAAEKFGRKPVLMVNILFF---SFFELCTAAAPSLTVFLILRVIYGVAMGG 114
Cdd:cd17432   43 LEESTLTLLWSLTVSIFPLGglfgSLLVGPLVIRLGRKGTLLLNNIFAivaAILMGLSKIAKSFEMIIVGRFLVGINAGI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 115 VWGVASSLAMETIPDRSRGLMSGIFQAGYPFGYLLAGVVyGL---LYSVVGWRGMFVIGAVP----VLLLPFIyfkvQES 187
Cdd:cd17432  123 SLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVL-GLrelLGNEEGWPLLLALTGVPallqLLTLPFF----PES 197

                        170
                 ....*....|....*
gi 516061913 188 PVWLAARERHESTAL 202
Cdd:cd17432  198 PRYLLIEKGDEEAAR 212

MFS_SV2A

cd17439

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...

60-198

7.68e-03

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 38.47 E-value: 7.68e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  60 IGALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRG------ 133
Cdd:cd17439   49 VGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGehlswl 128

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516061913 134 ----LMSGIFQAGYPFGYLLA---GVVYGLLYSVVGWRGMFVIGAVPVLLLPFIYFKVQESPVWLAARERHE 198
Cdd:cd17439  129 cmfwMIGGIYASAMAWAIIPHygwSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHD 200

MFS_YjiJ

cd06180

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...

61-386

8.45e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.05 E-value: 8.45e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  61 GALLFGRAAEKFGRKPVLMVNILFFSFFELCTAAAPSLTVFLILRVIYGVAMGGVWGVASSLAMETIPDRSRGLMSGIFQ 140
Cdd:cd06180   50 GALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLF 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 141 AGYPFGYLLAGV-----VYGLLYSVVGWRGM----FVIGAVPVLLLPFIYFKVQESPVWLAARERHESTALlpvlkshwk 211
Cdd:cd06180  130 AGVGLGIALSGLlvpagLGGGLSWRAGWLALallsAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRPLWR--------- 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 212 lcvyLVVLMAAFNFFSHGTQDLYPTFLKVQHGFDAHTVSIIAIcYNIASIIGGVTFGTLSERIGRKKAIIIA-ALLSLPV 290
Cdd:cd06180  201 ----LALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSL-FGLAAVPSCFLWGALSDRWGTRRALAANlLVQAVGV 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 291 LPLWAFAGGSWtLGIGAFLMQFMVQGAWGVIPTYLTELVPANTRAVLPGF--VYQLGNLIASVNATLQAyiAESHGHNYG 368
Cdd:cd06180  276 LLPLLSPGPAG-LVLSAVLFGGTFMAITALVMALARELAPPAAPRALALMtaSFGVGQILGPLLAGWLA--DATGGFAPA 352

                        330
                 ....*....|....*...
gi 516061913 369 LAMAMVAGTVAIVISVLV 386
Cdd:cd06180  353 LILAAAALVVAALLALLV 370

MFS_MFSD14

cd17387

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...

62-301

8.65e-03

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 38.17 E-value: 8.65e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913  62 ALLFGRAAEKFGRKPVLMVNIlFFSFFELCTAAAPSLTVFLILRViygvamGGVWGVASSLAMETIPD------RSR--G 133
Cdd:cd17387   53 APLIGALSDVWGRKSFLLLTV-FFTCAPIPLMRISPWWYFAMISV------SGIFSVTFSVIFAYVADitteeeRSTayG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 134 LMSGIFQAGYPF-----GYLLAgvVYGLLYSVVgwrgmfVIGAVPVLLLPFIYFKVQES------PVWLAARERHESTAL 202
Cdd:cd17387  126 LVSATFAASLVTspalgAYLSE--SYGDNLVVL------VATIVALLDICFILLAVPESlpekmrPASWGAPISWEQADP 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516061913 203 LPVLKSHWK----LCVYLVVLMAAFNFfsHGTQDLYPTFLKVQHGFDAHTVSIIAICYNIASIIGGVTFGT-LSERIGRK 277
Cdd:cd17387  198 FASLRKVGKdktvLLICITVFLSYLPE--AGQYSSFFVYLKQVMGFEYEEVAAFIAVVGILSITAQTLLLSiLMRSIGAK 275

                        250       260
                 ....*....|....*....|....
gi 516061913 278 KAIIIAALLSLPVLPLWAFAGGSW 301
Cdd:cd17387  276 NTILLGLGFQMLQLAWYGFGSQHW 299

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01