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Conserved domains on  [gi|516086220|ref|WP_017516800|]
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ANTAR domain-containing response regulator [Pseudomonas nitroreducens]

Protein Classification

ANTAR domain-containing response regulator( domain architecture ID 11467116)

ANTAR domain-containing response regulator, a response regulator with a signal receiver (REC) domain and RNA binding antiterminator (ANTAR) domain involved in transcriptional antitermination, similar to Mycobacterium tuberculosis transcriptional regulatory protein pdtaR that is a member of the two-component regulatory system pdtaR/pdtaS

Gene Ontology:  GO:0000160
PubMed:  11557134|20226724|16740923|11796212|18076326|11934609
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-192 2.43e-60

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 186.32  E-value: 2.43e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   1 MLRVLLINDTPKKVGRLKAALVECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFT 80
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVILLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220  81 DEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQLQAREQQLAERKRIELAKGLLMKMKGCAEEE 160
Cdd:COG3707   83 AYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSEDE 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 516086220 161 AYTLMRRQAMGRQQKLVQVAEQIIAMHEMLGH 192
Cdd:COG3707  163 AYRLLRKQAMDRRVKLAEVAEAILAAAELLKG 194
 
Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-192 2.43e-60

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 186.32  E-value: 2.43e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   1 MLRVLLINDTPKKVGRLKAALVECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFT 80
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVILLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220  81 DEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQLQAREQQLAERKRIELAKGLLMKMKGCAEEE 160
Cdd:COG3707   83 AYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSEDE 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 516086220 161 AYTLMRRQAMGRQQKLVQVAEQIIAMHEMLGH 192
Cdd:COG3707  163 AYRLLRKQAMDRRVKLAEVAEAILAAAELLKG 194
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 130-184 2.06e-12

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 59.41  E-value: 2.06e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 516086220   130 LQAREQQLAERKRIELAKGLLMKMKGCAEEEAYTLMRRQAMGRQQKLVQVAEQII 184
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAIV 55
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 137-181 5.06e-12

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 58.11  E-value: 5.06e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 516086220  137 LAERKRIELAKGLLMKMKGCAEEEAYTLMRRQAMGRQQKLVQVAE 181
Cdd:pfam03861   2 LESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 2-119 2.95e-11

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 57.81  E-value: 2.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   2 LRVLLINDTPKKVGRLKAALVECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFTD 81
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPIVLLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 516086220  82 EHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMAR 119
Cdd:cd19932   81 YSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-140 3.62e-05

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 43.30  E-value: 3.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   3 RVLLINDTPKKVGRLKAALVECGFEVIDES-GLTVdlAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFT 80
Cdd:PRK11361   6 RILIVDDEDNVRRMLSTAFALQGFETHCANnGRTA--LHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRtPVILMT 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220  81 DEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMARfesdQALRAQLQAREQQLAER 140
Cdd:PRK11361  84 AYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQL----QSMKKEIRHLHQALSTS 139
 
Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-192 2.43e-60

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 186.32  E-value: 2.43e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   1 MLRVLLINDTPKKVGRLKAALVECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFT 80
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVILLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220  81 DEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQLQAREQQLAERKRIELAKGLLMKMKGCAEEE 160
Cdd:COG3707   83 AYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSEDE 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 516086220 161 AYTLMRRQAMGRQQKLVQVAEQIIAMHEMLGH 192
Cdd:COG3707  163 AYRLLRKQAMDRRVKLAEVAEAILAAAELLKG 194
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 130-184 2.06e-12

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 59.41  E-value: 2.06e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 516086220   130 LQAREQQLAERKRIELAKGLLMKMKGCAEEEAYTLMRRQAMGRQQKLVQVAEQII 184
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAIV 55
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 137-181 5.06e-12

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 58.11  E-value: 5.06e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 516086220  137 LAERKRIELAKGLLMKMKGCAEEEAYTLMRRQAMGRQQKLVQVAE 181
Cdd:pfam03861   2 LESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 2-119 2.95e-11

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 57.81  E-value: 2.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   2 LRVLLINDTPKKVGRLKAALVECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFTD 81
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPIVLLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 516086220  82 EHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMAR 119
Cdd:cd19932   81 YSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-147 2.66e-10

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 56.84  E-value: 2.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   1 MLRVLLINDTPKKVGRLKAALVECGFEVID-ESGLtvDLAQRVEALHPDVILIDTESP---GRDVMEQVvlvsRDQPR-- 74
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEaADGE--EALELLQEHRPDLILLDLEMPdmdGLELCRRL----RADPRta 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516086220  75 --PIVMFTDEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAmARFESDQ---ALRAQLQAREQQLAERKRIELAK 147
Cdd:COG3706   75 diPIIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLV-ARYGGEEfaiLLPGTDLEGALAVAERIREAVAE 151
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 17-100 3.72e-10

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 54.83  E-value: 3.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220  17 LKAALV-ECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTDEHDPQVMRQAIRS 94
Cdd:cd17535   14 LRRLLEsEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDlKVIVLTAHDDPEYVLRALKA 93


                 ....*.
gi 516086220  95 GVSAYI 100
Cdd:cd17535   94 GAAGYL 99
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-135 1.22e-09

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 55.56  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   1 MLRVLLINDTPKKVGRLKAALVECGFEVID-ESGltVDLAQRVEALHPDVILIDTESPGRD---VMEQVVLVSRDQPRPI 76
Cdd:COG3437    6 APTVLIVDDDPENLELLRQLLRTLGYDVVTaESG--EEALELLLEAPPDLILLDVRMPGMDgfeLLRLLRADPSTRDIPV 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 516086220  77 VMFTDEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQLQAREQ 135
Cdd:COG3437   84 IFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELDDLVLYLKL 142
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 3-109 1.30e-09

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 53.44  E-value: 1.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   3 RVLLINDTPKKVGRLKAALVECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPRP-IVMFTD 81
Cdd:cd17542    2 KVLIVDDAAFMRMMLKDILTKAGYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAkVIMCSA 81

                         90       100
                 ....*....|....*....|....*...
gi 516086220  82 EHDPQVMRQAIRSGVSAYIVEGIQAQRL 109
Cdd:cd17542   82 MGQEEMVKEAIKAGAKDFIVKPFQPERV 109
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-101 3.91e-09

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 51.84  E-value: 3.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   5 LLINDTPKKVGRLKAALVECGFEViDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTDEH 83
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEV-DTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDiPVIVLTAKA 79

                         90
                 ....*....|....*...
gi 516086220  84 DPQVMRQAIRSGVSAYIV 101
Cdd:cd00156   80 DEEDAVRALELGADDYLV 97
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-129 1.40e-08

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 53.43  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   1 MLRVLLINDTPKKVGRLKAALVECGFEVIDESGLTVDLAqRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMF 79
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALA-LLREEPPDLVLLDLRMPGMDGLELLRELRALDPDlPVILL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 516086220  80 TDEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQ 129
Cdd:COG2204   81 TGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRRENAED 130
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-121 1.80e-08

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 50.74  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   1 MLRVLLINDTPKkVGRLKAALVE--CGFEVIDESGlTVDLAQR-VEALHPDVILIDTESPGRDVMEQVVLVSRDQPR-PI 76
Cdd:COG4565    3 MIRVLIVEDDPM-VAELLRRYLErlPGFEVVGVAS-SGEEALAlLAEHRPDLILLDIYLPDGDGLELLRELRARGPDvDV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 516086220  77 VMFTDEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMARFE 121
Cdd:COG4565   81 IVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRR 125
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-114 9.59e-07

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 45.70  E-value: 9.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   2 LRVLLINDTPKkVGRLKAALVEC--GFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQV-VLVSRDQPRPIVM 78
Cdd:cd19925    1 INVLIVEDDPM-VAEIHRAYVEQvpGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLrELRAAGHDVDVIV 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 516086220  79 FTDEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILD 114
Cdd:cd19925   80 VTAANDVETVREALRLGVVDYLIKPFTFERLRQRLE 115
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-119 1.18e-06

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 45.61  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   1 MLRVLLINDTPKKVGRLKAALVECGFEVID-ESGLtvDLAQRVEALHPDVILIDTESP---GRDVMEQVVLVSRDQPRPI 76
Cdd:COG0784    5 GKRILVVDDNPDNRELLRRLLERLGYEVTTaEDGA--EALELLRAGPPDLILLDINMPgmdGLELLRRIRALPRLPDIPI 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 516086220  77 VMFTDEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMAR 119
Cdd:COG0784   83 IALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLAR 125
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-134 1.10e-05

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 44.42  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   1 MLRVLLINDTPKKVGRLKAALVEC-GFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMF 79
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKYpDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 516086220  80 TDEHDpQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQLQARE 134
Cdd:COG3279   81 TTAYD-EYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKD 134
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-140 3.62e-05

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 43.30  E-value: 3.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   3 RVLLINDTPKKVGRLKAALVECGFEVIDES-GLTVdlAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFT 80
Cdd:PRK11361   6 RILIVDDEDNVRRMLSTAFALQGFETHCANnGRTA--LHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRtPVILMT 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220  81 DEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVAMARfesdQALRAQLQAREQQLAER 140
Cdd:PRK11361  84 AYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQL----QSMKKEIRHLHQALSTS 139
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-101 3.72e-05

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 42.64  E-value: 3.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   1 MLRVLLINDTPKKVGRLKAALVECGFEViDESGLTVDLAQRVEALHPDVILIDTESPGRD---VMEQVvlvsRDQPR--P 75
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEV-DTAADGEEALELLEEERPDLILLDLMLPGMDgleVCRRL----RARPSdiP 75

                         90       100
                 ....*....|....*....|....*.
gi 516086220  76 IVMFTDEHDPQVMRQAIRSGVSAYIV 101
Cdd:COG0745   76 IIMLTARDDEEDRVRGLEAGADDYLT 101
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-101 8.44e-05

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 40.14  E-value: 8.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   3 RVLLINDTPKKVGRLKAALV-ECGFEVIDE--SGLtvDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVM 78
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEwEAGFEVVGEaeNGE--EALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDtKIII 78

                         90       100
                 ....*....|....*....|...
gi 516086220  79 FTDEHDPQVMRQAIRSGVSAYIV 101
Cdd:COG4753   79 LSGYSDFEYAQEAIKLGADDYLL 101
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 2-116 1.57e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 39.63  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   2 LRVLLINDTPKKVGRLKAALVECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPR---PIVM 78
Cdd:cd19923    1 MKVLVVDDFSTMRRIIKNLLKELGFNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGALshlPVLM 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 516086220  79 FTDEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILDVA 116
Cdd:cd19923   81 VTAEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKI 118
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 3-117 1.93e-04

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 39.49  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   3 RVLLINDTPKKVGRLKAALVECGFEVID----ESGLTVdlaqrVEALHPDVILIDTESPGRDVMEQVVLVSRDQPR-PIV 77
Cdd:cd17555    2 TILVIDDDEVVRESIAAYLEDSGFQVLQaadgRQGLEL-----FRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDtPVI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 516086220  78 MFTDEHDPQVMRQAIRSGVSAYIVegiqaqrlQPILDVAM 117
Cdd:cd17555   77 VVSGAGVMSDAVEALRLGAWDYLT--------KPIEDLAV 108
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 1-80 5.13e-04

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 39.62  E-value: 5.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   1 MLRVLLINDTPKkVGRLKAA-LVECGFEVIDES-GltvDLAQ-RVEALHPDVILIDTESPGRDVMEqvvlVSRD-QPR-- 74
Cdd:PRK10701   1 MNKIVFVEDDAE-VGSLIAAyLAKHDIDVTVEPrG---DRAEaTILREQPDLVLLDIMLPGKDGMT----ICRDlRPKwq 72


                 ....*..
gi 516086220  75 -PIVMFT 80
Cdd:PRK10701  73 gPIVLLT 79
PRK10610 PRK10610
chemotaxis protein CheY;
2-114 1.03e-03

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 37.65  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   2 LRVLLINDTPKKVGRLKAALVECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRD---QPRPIVM 78
Cdd:PRK10610   6 LKFLVVDDFSTMRRIVRNLLKELGFNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADgamSALPVLM 85

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 516086220  79 FTDEHDPQVMRQAIRSGVSAYIVEGIQAQRLQPILD 114
Cdd:PRK10610  86 VTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLN 121
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-109 1.66e-03

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 36.75  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220    4 VLLINDTPKKVGRLKAALVECGFEViDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTDE 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVV-AEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTtPVIILTAH 79

                          90       100
                  ....*....|....*....|....*..
gi 516086220   83 HDPQVMRQAIRSGVSAYIVEGIQAQRL 109
Cdd:pfam00072  80 GDEDDAVEALEAGADDFLSKPFDPDEL 106
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 43-101 2.37e-03

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 36.63  E-value: 2.37e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516086220  43 EALHPDVILIDTESP---GRDVMEQVvlvsRDQPR----PIVMFTDEHDPQVMRQAIRSGVSAYIV 101
Cdd:cd17557   49 DAPRPDLILLDLNMPrmdGFEVLREI----KADPDlrriPVVVLTTSDAEEDIERAYELGANSYIV 110
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 3-109 3.92e-03

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 35.74  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   3 RVLLINDTPKKVGRLKAALVECGFEVID----ESGLTVDLAQRVealhpDVILIDTESPGRDVMEQVVLVsRDQPR---- 74
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGAGYEVVEaadgRDALSKAQSKKF-----DLIITDQNMPNMDGIELIKEL-RKLPAykft 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 516086220  75 PIVMFTDEHDPQVMRQAIRSGVSAYIVEGIQAQRL 109
Cdd:cd17562   76 PILMLTTESSDEKKQEGKAAGATGWLVKPFDPEQL 110
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 17-109 4.61e-03

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 35.71  E-value: 4.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220  17 LKAALV-----ECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTDEHDPQVMRQ 90
Cdd:cd19930   10 VRGALAallelEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDtKVLIVTTFGRPGYFRR 89

                         90
                 ....*....|....*....
gi 516086220  91 AIRSGVSAYIVEGIQAQRL 109
Cdd:cd19930   90 ALAAGVDGYVLKDRPIEEL 108
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 3-101 4.84e-03

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 35.43  E-value: 4.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   3 RVLLINDTPKKVGRLKAALVECGFEVIDES-GLTVdlAQRVEALHPDVILIDTESPGRDVMEqvvlVSRDQPR----PIV 77
Cdd:cd17622    2 RILLVEDDPKLARLIADFLESHGFNVVVEHrGDRA--LEVIAREKPDAVLLDIMLPGIDGLT----LCRDLRPkyqgPIL 75

                         90       100
                 ....*....|....*....|....
gi 516086220  78 MFTDEHDPQVMRQAIRSGVSAYIV 101
Cdd:cd17622   76 LLTALDSDIDHILGLELGADDYVV 99
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 3-139 4.90e-03

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 37.12  E-value: 4.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   3 RVLLINDTPKKVGRLKAALVECGFEVIDESGLTVDLAqRVEALHPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTD 81
Cdd:PRK13558   9 GVLFVGDDPEAGPVDCDLDEDGRLDVTQIRDFVAARD-RVEAGEIDCVVADHEPDGFDGLALLEAVRQTTAVpPVVVVPT 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516086220  82 EHDPQVMRQAIRSGVSAYI-----------VEGIQAQRLQPILDVAMARFESDQALRAQLQAREQQLAE 139
Cdd:PRK13558  88 AGDEAVARRAVDADAAAYVpavsddataaiAERIESAVPEHSRDTEARMPISDLTVESDRRLKERALDE 156
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 3-153 5.75e-03

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 36.16  E-value: 5.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   3 RVLLINDTP---KKVGRLKAAlvECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVMEQVV-LVSRDQPRPIVM 78
Cdd:PRK10651   8 TILLIDDHPmlrTGVKQLISM--APDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDkLREKSLSGRIVV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220  79 FT-DEHDPQVMrQAIRSGVSAY---------IVEGIQA---------QRLQPILDVAM-ARFESDQALRAQLQAREQQLA 138
Cdd:PRK10651  86 FSvSNHEEDVV-TALKRGADGYllkdmepedLLKALQQaaagemvlsEALTPVLAASLrANRATTERDVNQLTPRERDIL 164

                        170
                 ....*....|....*
gi 516086220 139 ERkrieLAKGLLMKM 153
Cdd:PRK10651 165 KL----IAQGLPNKM 175
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-63 7.12e-03

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 35.25  E-value: 7.12e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516086220   1 MLRVLLINDTPKKVGRLKAAL-VECGFEVIDESGLTVDLAQRVEALHPDVILIDTESPGRDVME 63
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLeAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLE 64
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 4-109 8.54e-03

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 34.87  E-value: 8.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   4 VLLINDTPKKVGRLKAALVECGFEV-IDESGltVDLAQRVEALHPDVILIDTESP---GRDVMEQVvlVSRDQPRPIVMF 79
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVtHVETG--KEALAFLSDQPPDVVLLDLKLPdmsGMEILKWI--QERSLPTSVIVI 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 516086220  80 TDEHDPQVMRQAIRSGVSAYIVEGIQAQRL 109
Cdd:cd17572   77 TAHGSVDIAVEAMRLGAYDFLEKPFDADRL 106
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 3-95 8.88e-03

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 34.40  E-value: 8.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516086220   3 RVLLINDTPKKVGRLKAALVECGFEVID-ESGLtvDLAQRVEALHPDVILIDTESPGRDVMEqVVLVSRDQPR----PIV 77
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAEGYEVLTaDSGQ--EALALAEEELPDLILLDVMMPGMDGFE-VCRRLKEDPEtrhiPVI 77

                         90
                 ....*....|....*...
gi 516086220  78 MFTDEHDPQVMRQAIRSG 95
Cdd:cd17538   78 MITALDDREDRIRGLEAG 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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