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Conserved domains on  [gi|516233921|ref|WP_017637884|]
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MULTISPECIES: cysteine hydrolase family protein [Staphylococcus]

Protein Classification

cysteine hydrolase family protein( domain architecture ID 10003554)

cysteine hydrolase family protein related to isochorismatase and nicotinamidase; catalyzes the hydrolysis of a chemical bond using an active site cysteinyl residue

CATH:  3.40.50.850
EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 5-182 5.24e-47

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 151.21  E-value: 5.24e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   5 ALIIVDYSVDFiADDGKLTCgVPGQKLENFLVNRINQFNENRDDIFFMMDLHYENDDFHPESKLFPPHNIEGSVGRQLYG 84
Cdd:COG1335    1 ALLVIDVQNDF-VPPGALAV-PGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  85 EVgklyesiKTQNNVHFLDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVASFNQ 164
Cdd:COG1335   79 EL-------APLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                        170
                 ....*....|....*...
gi 516233921 165 SGHQWALSHFENsLGAEV 182
Cdd:COG1335  152 EAHEAALARLRA-AGATV 168
 
Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 5-182 5.24e-47

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 151.21  E-value: 5.24e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   5 ALIIVDYSVDFiADDGKLTCgVPGQKLENFLVNRINQFNENRDDIFFMMDLHYENDDFHPESKLFPPHNIEGSVGRQLYG 84
Cdd:COG1335    1 ALLVIDVQNDF-VPPGALAV-PGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  85 EVgklyesiKTQNNVHFLDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVASFNQ 164
Cdd:COG1335   79 EL-------APLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                        170
                 ....*....|....*...
gi 516233921 165 SGHQWALSHFENsLGAEV 182
Cdd:COG1335  152 EAHEAALARLRA-AGATV 168
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 5-175 2.15e-42

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 139.33  E-value: 2.15e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   5 ALIIVDYSVDFIADDGKLTcgVPGQKLENFLVNRINQFNENRDDIFFMMDLHYENDDFHPESkLFPPHNIEGSVGRQLYG 84
Cdd:cd00431    1 ALLVVDMQNDFVPGGGLLL--PGADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAEL-LWPPHCVKGTEGAELVP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  85 EvgklyesIKTQNNVHFLDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVASFNQ 164
Cdd:cd00431   78 E-------LAPLPDDLVIEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDE 150

                        170
                 ....*....|.
gi 516233921 165 SGHQWALSHFE 175
Cdd:cd00431  151 EDHEAALERLA 161
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 4-182 7.12e-39

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 130.60  E-value: 7.12e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921    4 TALIIVDYSVDFIADDGKLTCGVPgQKLENflVNR-INQFNENRDDIFFMMDLHYENDDFHPESKLFPPHNIEGSVGRQL 82
Cdd:pfam00857   1 TALLVIDMQNDFVDSGGPKVEGIA-AILEN--INRlLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGTTGAEL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   83 YGEvgklyesIKTQNNVHFLDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVASF 162
Cdd:pfam00857  78 VPE-------LAPLPGDLVVDKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASL 150

                         170       180
                  ....*....|....*....|
gi 516233921  163 NQSGHQWALSHFENSlGAEV 182
Cdd:pfam00857 151 SPEAHDAALERLAQR-GAEV 169
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 1-154 1.45e-18

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 79.34  E-value: 1.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   1 MTKTALIIVDYSVDFIADdGKLtcGVPGQkleNFLVNRINQFNENR--DDIFFMMDLHYEN-------DDFHPESK---- 67
Cdd:PTZ00331  10 STNDALIIVDVQNDFCKG-GSL--AVPDA---EEVIPVINQVRQSHhfDLVVATQDWHPPNhisfasnHGKPKILPdgtt 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  68 --LFPPHNIEGSVGRQLYgevgklyESIKTQNNVHFLDK---TRYDSFYG--------TPLDSLLRERNVNKVEIVGVCT 134
Cdd:PTZ00331  84 qgLWPPHCVQGTKGAQLH-------KDLVVERIDIIIRKgtnRDVDSYSAfdndkgskTGLAQILKAHGVRRVFICGLAF 156

                        170       180
                 ....*....|....*....|
gi 516233921 135 DICVLHTAISAYNLGYAIRV 154
Cdd:PTZ00331 157 DFCVLFTALDAVKLGFKVVV 176
 
Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 5-182 5.24e-47

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 151.21  E-value: 5.24e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   5 ALIIVDYSVDFiADDGKLTCgVPGQKLENFLVNRINQFNENRDDIFFMMDLHYENDDFHPESKLFPPHNIEGSVGRQLYG 84
Cdd:COG1335    1 ALLVIDVQNDF-VPPGALAV-PGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  85 EVgklyesiKTQNNVHFLDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVASFNQ 164
Cdd:COG1335   79 EL-------APLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                        170
                 ....*....|....*...
gi 516233921 165 SGHQWALSHFENsLGAEV 182
Cdd:COG1335  152 EAHEAALARLRA-AGATV 168
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 5-175 2.15e-42

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 139.33  E-value: 2.15e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   5 ALIIVDYSVDFIADDGKLTcgVPGQKLENFLVNRINQFNENRDDIFFMMDLHYENDDFHPESkLFPPHNIEGSVGRQLYG 84
Cdd:cd00431    1 ALLVVDMQNDFVPGGGLLL--PGADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAEL-LWPPHCVKGTEGAELVP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  85 EvgklyesIKTQNNVHFLDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVASFNQ 164
Cdd:cd00431   78 E-------LAPLPDDLVIEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDE 150

                        170
                 ....*....|.
gi 516233921 165 SGHQWALSHFE 175
Cdd:cd00431  151 EDHEAALERLA 161
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 4-182 7.12e-39

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 130.60  E-value: 7.12e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921    4 TALIIVDYSVDFIADDGKLTCGVPgQKLENflVNR-INQFNENRDDIFFMMDLHYENDDFHPESKLFPPHNIEGSVGRQL 82
Cdd:pfam00857   1 TALLVIDMQNDFVDSGGPKVEGIA-AILEN--INRlLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGTTGAEL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   83 YGEvgklyesIKTQNNVHFLDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVASF 162
Cdd:pfam00857  78 VPE-------LAPLPGDLVVDKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASL 150

                         170       180
                  ....*....|....*....|
gi 516233921  163 NQSGHQWALSHFENSlGAEV 182
Cdd:pfam00857 151 SPEAHDAALERLAQR-GAEV 169
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 5-172 7.71e-24

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 91.50  E-value: 7.71e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   5 ALIIVDYSVDFiaDDGKLtcgvPGQKLENFLVN---RINQFNENRDDIFFMMDLHYENDDFHPESklfpphniegsvgrq 81
Cdd:cd01014    1 ALLVIDVQNGY--FDGGL----PPLNNEAALENiaaLIAAARAAGIPVIHVRHIDDEGGSFAPGS--------------- 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  82 lygEVGKLYESIKTQNNVHFLDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVAS 161
Cdd:cd01014   60 ---EGWEIHPELAPLEGETVIEKTVPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACAT 136

                        170
                 ....*....|.
gi 516233921 162 FNQSGHQWALS 172
Cdd:cd01014  137 FDLPDHGGVLS 147
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 1-154 1.45e-18

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 79.34  E-value: 1.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   1 MTKTALIIVDYSVDFIADdGKLtcGVPGQkleNFLVNRINQFNENR--DDIFFMMDLHYEN-------DDFHPESK---- 67
Cdd:PTZ00331  10 STNDALIIVDVQNDFCKG-GSL--AVPDA---EEVIPVINQVRQSHhfDLVVATQDWHPPNhisfasnHGKPKILPdgtt 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  68 --LFPPHNIEGSVGRQLYgevgklyESIKTQNNVHFLDK---TRYDSFYG--------TPLDSLLRERNVNKVEIVGVCT 134
Cdd:PTZ00331  84 qgLWPPHCVQGTKGAQLH-------KDLVVERIDIIIRKgtnRDVDSYSAfdndkgskTGLAQILKAHGVRRVFICGLAF 156

                        170       180
                 ....*....|....*....|
gi 516233921 135 DICVLHTAISAYNLGYAIRV 154
Cdd:PTZ00331 157 DFCVLFTALDAVKLGFKVVV 176
nicotinamidase cd01011
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, ...
 3-154 1.41e-16

Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).


Pssm-ID: 238493  Cd Length: 196  Bit Score: 73.84  E-value: 1.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   3 KTALIIVDYSVDFIaDDGKLtcGVPGQkleNFLVNRINQFNENRDD--IFFMMDLHYEN----DDFHPESKLF------- 69
Cdd:cd01011    1 TDALLVVDVQNDFC-PGGAL--AVPGG---DAIVPLINALLSLFQYdlVVATQDWHPANhasfASNHPGQMPFitlppgp 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  70 ----PPHNIEGSVGRQLYGEvgklyesIKTQNNVHFLDK-TR-----YDSFYG------TPLDSLLRERNVNKVEIVGVC 133
Cdd:cd01011   75 qvlwPDHCVQGTPGAELHPG-------LPVPDIDLIVRKgTNpdidsYSAFFDndrrssTGLAEYLRERGIDRVDVVGLA 147

                        170       180
                 ....*....|....*....|.
gi 516233921 134 TDICVLHTAISAYNLGYAIRV 154
Cdd:cd01011  148 TDYCVKATALDALKAGFEVRV 168
EntB1 COG1535
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
102-171 5.01e-12

Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441144 [Multi-domain]  Cd Length: 204  Bit Score: 61.79  E-value: 5.01e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921 102 LDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVASFNQSGHQWAL 171
Cdd:COG1535  110 LTKWRYSAFQRTDLEERLRELGRDQLIITGVYAHIGCLATAVDAFMRDIQPFVVADAVADFSREEHRMAL 179
CSHase cd01015
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, ...
 5-184 7.05e-09

N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.


Pssm-ID: 238497 [Multi-domain]  Cd Length: 179  Bit Score: 52.79  E-value: 7.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   5 ALIIVDYSVDFiADDGKLTC-GVPGQkLENflVNRINQFNENRDDIFFMMDLHYENDDfhPESKLFP---PHNIEGSVGR 80
Cdd:cd01015    1 ALLVIDLVEGY-TQPGSYLApGIAAA-LEN--VQRLLAAARAAGVPVIHTTVVYDPDG--ADGGLWArkvPAMSDLVEGS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  81 QLygevGKLYESIKTQNNVHFLDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVA 160
Cdd:cd01015   75 PL----AAICDELAPQEDEMVLVKKYASAFFGTSLAATLTARGVDTLIVAGCSTSGCIRATAVDAMQHGFRPIVVRECVG 150

                        170       180
                 ....*....|....*....|....
gi 516233921 161 SFNQSGHQWALSHFENSLGAEVEE 184
Cdd:cd01015  151 DRAPAPHEANLFDIDNKYGDVVST 174
PLN02743 PLN02743
nicotinamidase
 3-163 9.01e-09

nicotinamidase


Pssm-ID: 215396  Cd Length: 239  Bit Score: 53.20  E-value: 9.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921   3 KTALIIVDYSVDFIA-DDGKLTCGVPGQKLENfLVN---RI-NQFNENRDDIFFMMDLHYENDDFHPesklFPPHNIEGS 77
Cdd:PLN02743  27 RTGLVLVDEVNGFCTvGAGNLAPREPDKQISK-MVDesaRLaREFCERKWPVLAFLDSHHPDKPEHP----YPPHCIVGT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  78 VGRQLYGEVgklyESIKTQNNVHFLDKTRYDSFYGTPLDS-------LLRERNVNKVEIVGVCTDICVLH---TAISAYN 147
Cdd:PLN02743 102 GEENLVPAL----QWLENDPNVTLRRKDCIDGFVGAIEKDgsnvfvdWVNNNKIKVILVVGICTDICVLDfvaSALSARN 177

                        170       180
                 ....*....|....*....|.
gi 516233921 148 LGYA-----IRVPSKGVASFN 163
Cdd:PLN02743 178 HGILppledVVVYSRGCATYD 198
isochorismatase cd01013
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the ...
 102-171 1.63e-07

Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological systems. Isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.


Pssm-ID: 238495  Cd Length: 203  Bit Score: 49.26  E-value: 1.63e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921 102 LDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVASFNQSGHQWAL 171
Cdd:cd01013  120 LTKWRYSAFKRSPLLERLKESGRDQLIITGVYAHIGCLSTAVDAFMRDIQPFVVADAIADFSLEEHRMAL 189
PLN02621 PLN02621
nicotinamidase
 74-171 2.85e-07

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 48.62  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921  74 IEGSVGRQLYGEVGKLYESIKtqnnvhFLDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIR 153
Cdd:PLN02621  83 LDGTTEAELMPEIGRVTGPDE------VVEKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVF 156

                         90
                 ....*....|....*...
gi 516233921 154 VPSKGVASFNQSGHQWAL 171
Cdd:PLN02621 157 FSTDATATANEELHEATL 174
PRK11440 PRK11440
putative hydrolase; Provisional
 104-173 1.25e-06

putative hydrolase; Provisional


Pssm-ID: 183137  Cd Length: 188  Bit Score: 46.65  E-value: 1.25e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921 104 KTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVASFNQSGHQWALSH 173
Cdd:PRK11440 101 KRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELGFNLVIAEDACSAASAEQHQNSMNH 170
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 102-171 1.94e-06

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 45.66  E-value: 1.94e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516233921 102 LDKTRYDSFYGTPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKGVASFNQSGHQWAL 171
Cdd:cd01012   66 IEKTSFSCWEDEAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVADACGSRSKEDHELAL 135
PRK11609 PRK11609
bifunctional nicotinamidase/pyrazinamidase;
113-158 8.47e-06

bifunctional nicotinamidase/pyrazinamidase;


Pssm-ID: 183228  Cd Length: 212  Bit Score: 44.21  E-value: 8.47e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 516233921 113 TPLDSLLRERNVNKVEIVGVCTDICVLHTAISAYNLGYAIRVPSKG 158
Cdd:PRK11609 131 TALDDWLREHGITELIVMGLATDYCVKFTVLDALALGYQVNVITDG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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