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Conserved domains on  [gi|516234318|ref|WP_017638281|]
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MULTISPECIES: MFS transporter [Staphylococcus]

Protein Classification

MDR family MFS transporter( domain architecture ID 13023665)

MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
7-364 3.51e-88

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 271.41  E-value: 3.51e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   7 VWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTT 86
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  87 LLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQ-TFNAIYLAQNIGVALGAALGGFVAEFSFNYIFMANL 165
Cdd:cd17329   81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 166 IMYVLFALVAITQFNLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASF-TQSIHISMSQYSV 244
Cdd:cd17329  161 VLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYvVEILGLGESLLGL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 245 LWTINGIMILVAQPLIRPVIvlLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLA 324
Cdd:cd17329  241 LLALNALLIVLLQFPVARLV--ERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALA 318
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 516234318 325 PEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:cd17329  319 PPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
7-364 3.51e-88

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 271.41  E-value: 3.51e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   7 VWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTT 86
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  87 LLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQ-TFNAIYLAQNIGVALGAALGGFVAEFSFNYIFMANL 165
Cdd:cd17329   81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 166 IMYVLFALVAITQFNLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASF-TQSIHISMSQYSV 244
Cdd:cd17329  161 VLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYvVEILGLGESLLGL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 245 LWTINGIMILVAQPLIRPVIvlLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLA 324
Cdd:cd17329  241 LLALNALLIVLLQFPVARLV--ERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALA 318
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 516234318 325 PEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:cd17329  319 PPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-343 2.74e-29

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 116.23  E-value: 2.74e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   5 KSVWWLVIGMALNITGASFLWPLNTiYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFS 84
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  85 TTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-FSFNYIFM 162
Cdd:COG2814   89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLgAGLGLGPALGPLLGGLLADlFGWRWVFL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 163 ANLIMYVLFALVAItqfnLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASFTQSI-HISMSQ 241
Cdd:COG2814  169 VNAVLALLALLLLL----RLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASA 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 242 YSVLWTINGIMILVAQPLIRPVIvlLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIAN 321
Cdd:COG2814  245 AGLLLALFGLGGVLGALLAGRLA--DRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
                        330       340
                 ....*....|....*....|..
gi 516234318 322 QLAPEGKVGQYQGIVNSASTVG 343
Cdd:COG2814  323 ELAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
10-348 6.39e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 109.82  E-value: 6.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   10 LVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLN 89
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   90 LFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-FSFNYIFMANLIM 167
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVsAGFGLGAALGPLLGGLLASlFGWRAAFLILAIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  168 YVLFALVAI-----TQFNLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWettIASFTQSIHISMSQY 242
Cdd:pfam07690 161 SLLAAVLLLlprppPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTY---LPLYQEVLGLSALLA 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  243 SVLWTINGIMILVAQPLIRPVIVLLKGNLKKQMFVGIIIFMC-SFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIAN 321
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
                         330       340
                  ....*....|....*....|....*..
gi 516234318  322 QLAPEGKVGQYQGIVNSASTVGKALGP 348
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALGP 344
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
14-178 1.47e-05

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 47.23  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   14 MALNITGASFLWPLNTI-------YMKEELNKSLTI-AGVVLLINSLGMVVGNLLGGvlfdKLGGYKTIL-------IGT 78
Cdd:PRK08633  234 LWLAIIGLSYFWFISQLaqanfpaYAKEVLGLDNTFqVQYLLAASAIGIGIGSLLAG----RLSGRHIELglvplgaLGL 309
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   79 FTCLFsttLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGR-QTFNAIYLAQNIGVALGAALGGFVA--EF 155
Cdd:PRK08633  310 ALSLF---LLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELgKVLAANNFLQNVGMLLFLALTTLFSglGL 386
                         170       180
                  ....*....|....*....|...
gi 516234318  156 SFNYIFMANLIMYVLFALVAITQ 178
Cdd:PRK08633  387 SPAGLFYLIALVTLIGTLYTLLL 409
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
31-359 5.13e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 45.06  E-value: 5.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   31 YMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGM 110
Cdd:TIGR00881  20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGM 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  111 IIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAEFSFNY--IFMANLIMYVLFALVAIT---------- 177
Cdd:TIGR00881 100 GWPPCGRTVTKWFSRSERGTWVSFWnCSHNVGGGLLPPLVLFGIAELYSWhwVFIVPGIIAIIVSLICFLllrdspqscg 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  178 ------QFNLEINAKLKRQDNIDLKNQENV-----SRFVSLILVCVVF-AICWIGYIQWETTIAsfTQSIHIS---MSQY 242
Cdd:TIGR00881 180 lppaeeMPNEEPDGDAEKKEEELTKKQIFLqyvllNKVLWYISLGYVFvYVVRTGILDWSPLYL--TQEKGFSkekASWA 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  243 SVLWTINGIM-ILVAQPLIRPVIVLLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVI--LTFGEMFVWpavPTI 319
Cdd:TIGR00881 258 FTLYELGGLVgTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALgfLVYGPQMLI---GVI 334
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 516234318  320 ANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFN 359
Cdd:TIGR00881 335 ASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
7-364 3.51e-88

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 271.41  E-value: 3.51e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   7 VWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTT 86
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  87 LLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQ-TFNAIYLAQNIGVALGAALGGFVAEFSFNYIFMANL 165
Cdd:cd17329   81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 166 IMYVLFALVAITQFNLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASF-TQSIHISMSQYSV 244
Cdd:cd17329  161 VLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYvVEILGLGESLLGL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 245 LWTINGIMILVAQPLIRPVIvlLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLA 324
Cdd:cd17329  241 LLALNALLIVLLQFPVARLV--ERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALA 318
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 516234318 325 PEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:cd17329  319 PPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
10-364 1.93e-29

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 117.29  E-value: 1.93e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  10 LVIGMALNITGASFLWPLNTIYMKEeLNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLN 89
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  90 LFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYL-AQNIGVALGAALGGFVAE---FSFNYIFMANL 165
Cdd:cd17325   80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSsAIGLGFLIGPLLGGLLADalgYRAPFLVCAAL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 166 IMYVLFALVAITQFNLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASFTQS-IHISMSQYSV 244
Cdd:cd17325  160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGL 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 245 LWTINGIMILVAQPLIrpVIVLLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLA 324
Cdd:cd17325  240 LFGAQGLASALSQPPA--GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 516234318 325 PEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:cd17325  318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-343 2.74e-29

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 116.23  E-value: 2.74e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   5 KSVWWLVIGMALNITGASFLWPLNTiYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFS 84
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  85 TTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-FSFNYIFM 162
Cdd:COG2814   89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLgAGLGLGPALGPLLGGLLADlFGWRWVFL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 163 ANLIMYVLFALVAItqfnLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASFTQSI-HISMSQ 241
Cdd:COG2814  169 VNAVLALLALLLLL----RLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASA 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 242 YSVLWTINGIMILVAQPLIRPVIvlLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIAN 321
Cdd:COG2814  245 AGLLLALFGLGGVLGALLAGRLA--DRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
                        330       340
                 ....*....|....*....|..
gi 516234318 322 QLAPEGKVGQYQGIVNSASTVG 343
Cdd:COG2814  323 ELAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
10-348 6.39e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 109.82  E-value: 6.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   10 LVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLN 89
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   90 LFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-FSFNYIFMANLIM 167
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVsAGFGLGAALGPLLGGLLASlFGWRAAFLILAIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  168 YVLFALVAI-----TQFNLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWettIASFTQSIHISMSQY 242
Cdd:pfam07690 161 SLLAAVLLLlprppPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTY---LPLYQEVLGLSALLA 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  243 SVLWTINGIMILVAQPLIRPVIVLLKGNLKKQMFVGIIIFMC-SFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIAN 321
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
                         330       340
                  ....*....|....*....|....*..
gi 516234318  322 QLAPEGKVGQYQGIVNSASTVGKALGP 348
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-364 3.19e-19

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 88.00  E-value: 3.19e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   1 MNIPKSVWWLVIGMALNITGASFL----WPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILI 76
Cdd:COG2271    1 ARAPSRYRWRILALLFLAYFLNYLdrsnLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  77 GTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE- 154
Cdd:COG2271   81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFnAGGPLGGALAPPLLGWLLAa 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 155 FSFNYIFMANLIMYVLFALVaitqfnleinaklkrqdnidlknqenvsRFVSLILVCVVFAICWIGYIQWETTIasFTQS 234
Cdd:COG2271  161 FGWRAAFLILGLPGLLLALL----------------------------RFWLLALAYFLVYFALYGFLTWLPTY--LVEV 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 235 IHISMSQYSVLWTINGIMILVAQPLIRPVIVLLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWP 314
Cdd:COG2271  211 RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFG 290
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 516234318 315 AVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:COG2271  291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
35-364 1.27e-18

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 86.49  E-value: 1.27e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  35 ELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMIIPA 114
Cdd:cd17489   25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 115 IYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-FSFNYIFMANLIMYVLFALVAitqFNLEINAKLKRQDN 192
Cdd:cd17489  105 AATLVADIIPPSRRGEGIGYYgLATTLAMALGPALGLFLYQhLGFAVLFIVAAVLALLALLLV---FLVKDPPPVAAEEA 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 193 IDLKNQENVSRFVSLILVCVVFAICWIGYiqweTTIASFTQS--IHISMSQYSVLWTINGIMILVAQPLIRPVIvlLKGN 270
Cdd:cd17489  182 EAGTRAFRRLVEKKVLPPALILFLASIAY----GAISTFLPLyaAERGISNAGLFFTVYAIALLLSRPFSGKLS--DRKG 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 271 LKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLF 350
Cdd:cd17489  256 PKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLL 335
                        330
                 ....*....|....
gi 516234318 351 GGVLVDMFNMRIMF 364
Cdd:cd17489  336 LGLVAELFGYRAMF 349
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
10-354 1.31e-18

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 86.09  E-value: 1.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  10 LVIGMALNITGASFLWPLNTIYMKEELNKSLT--IAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTL 87
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  88 LNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAALGGFVAefSFNYIFMANLIM 167
Cdd:cd17330   81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS--TPYGYALPFLVA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 168 YVLFALVAItqfnleinaklkrqdnidlknqeNVSRFVS-LILVCVVFAICWIGYIQWETTIASFT-QSIHISMSQYSVL 245
Cdd:cd17330  159 AALALLNLV-----------------------LVLFFLPpLRRLLLVYFLIALAFAGLESVFSLFLkDRFGFSPSQIGLL 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 246 WTINGIMILVAQPLIRPVIVLLKGNlKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAP 325
Cdd:cd17330  216 LALVGIAGILAQLLLIPRLAKRLGE-RKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVP 294
                        330       340
                 ....*....|....*....|....*....
gi 516234318 326 EGKVGQYQGIVNSASTVGKALGPLFGGVL 354
Cdd:cd17330  295 SKEQGKAQGIIQSLQSLARIIGPLLAGPL 323
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
10-364 7.67e-18

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 84.14  E-value: 7.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  10 LVIGMALNITGAsfLWPlntiYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLN 89
Cdd:COG0738   18 FLWGFATALWGP--LIP----ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  90 LFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAALGGFVAEFSFN------YIFMA 163
Cdd:COG0738   92 LAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlswhlpYLILA 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 164 nLIMYVLFALVAITQF-NLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASFTQSIHISMSQY 242
Cdd:COG0738  172 -VLLLLLALLFLRSKLpEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAAL 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 243 SVLWTINGIMI--LVAQPLIRPVivllkgNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIA 320
Cdd:COG0738  251 GLSLFWGGMTIgrFLGGFLLKRF------GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLA 324
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 516234318 321 NQLAPEgKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:COG0738  325 LDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAF 367
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
32-364 2.84e-16

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 79.54  E-value: 2.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  32 MKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMI 111
Cdd:cd17474   25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 112 IPAIYAMAGAVWPNGGRQTFNAIYLAQN-IGVALGAALGGFVAEFSFNYIFMANLIMyVLFALVAITQFNLEINAKLKRQ 190
Cdd:cd17474  105 GPLALTLIGDLFEGGERAKAMGLYEAALgLGIAVGPLLGGLLAAISWRYPFFLLAAL-IPVAFLAILFLLPEPKEKAKSS 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 191 DNI---DLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASftQSIHISMSQYSVLWTINGIMILVAQPLIRPvIVLL 267
Cdd:cd17474  184 SATklrDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE--LLYGISPIIIGLLFAGWSVLLALGSLFVGR-LLKK 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 268 KGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALG 347
Cdd:cd17474  261 RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
                        330
                 ....*....|....*..
gi 516234318 348 PLFGGVLVDMFNMRIMF 364
Cdd:cd17474  341 PLLFGLLLEIFGLSAPF 357
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
30-359 1.78e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.08  E-value: 1.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  30 IYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGG 109
Cdd:cd06174   20 PALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 110 MIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE---FSFNYIFMANLIMYVLFALVAITQFNLEINA 185
Cdd:cd06174  100 LIDPAVLALIADLFPERERGRALGLLqAFGSVGGILGPLLGGILASslgFGWRAVFLIAAALALLAAILLLLVVPDPPES 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 186 KLKRQDNIDLKNQEN----VSRFVSLILVCVVFAICWIGYIQWETTIASF-TQSIHISMSQYSVLWTINGIMILVAQPLI 260
Cdd:cd06174  180 ARAKNEEASSKSVLKllkrVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFlLDLGGLSVAVAGLLLSLFGLAGALGSLLL 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 261 RPVIVLLKGnLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSAS 340
Cdd:cd06174  260 GLLSDRLIG-RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFG 338
                        330
                 ....*....|....*....
gi 516234318 341 TVGKALGPLFGGVLVDMFN 359
Cdd:cd06174  339 FLGGAIGPLLAGFLLAATF 357
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
4-176 8.04e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 75.31  E-value: 8.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   4 PKSVWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLF 83
Cdd:cd17325  198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  84 STTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-FSFNYIF 161
Cdd:cd17325  278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFnTAFSLGMVLGPLLGGFLYDaFGFATPF 357
                        170
                 ....*....|....*
gi 516234318 162 MANLIMYVLFALVAI 176
Cdd:cd17325  358 LAAAALLLLAAVLFL 372
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
8-364 1.59e-14

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 74.19  E-value: 1.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   8 WWLVIGMALNITGASFLWPLNTIYMKEeLNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTL 87
Cdd:cd06173    2 RLLWLAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  88 LNLFHGWPWYAVWLV-----LLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGF-VAEFSFNYI 160
Cdd:cd06173   81 LALLALLGSLSLWLLlvlafLLGIASAFFGPARQALLPELVPKEQLVRANALNsLATQLARIIGPALGGLlVALLGPGGA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 161 FMANLIMYVLFALVAIT-QFNLEINAKLKRQDNIDLK---NQENVSRFVSLILVCVVFAICWIGYIQWETTIASFTQSIH 236
Cdd:cd06173  161 FAINALSFLLSALLLLFiRRPPPAAPGESSSLLLRDLregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 237 ISMSQYSVLWTINGIMILVAqPLIRPVIVLLKGNLKKqMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAV 316
Cdd:cd06173  241 GGAAGYGLLLAAFGVGALLG-ALLLGRLSKRRRRGRL-LLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 516234318 317 PTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:cd06173  319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
7-358 5.39e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 69.91  E-value: 5.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   7 VWWLVIGMALNItGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTT 86
Cdd:COG2223    7 LLLATLAFFLAF-GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  87 LLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLA-QNIGVALGAALGGFVAE-FSFNYIFMAN 164
Cdd:COG2223   86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGgGNLGAAVAAFLAPLLIAaFGWRNAFLIL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 165 LIMYVLFALVAITQFNlEINAKLKRQDNIDLKNQENV---SRFVSLILVCVVFAICWIGYIQWETTIasFTQSIHISMSQ 241
Cdd:COG2223  166 GILLLVVAVLAWLFLR-DPPAGAAAAAKASLRDQLEAlrdPRFWLLSLLYFGTFGSFIGFSSWLPPY--LVDQFGLSAAT 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 242 YSVLWTINGIMILVAQPLIrPVIVLLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIAN 321
Cdd:COG2223  243 AGLLAALFALLGALGRPLG-GWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVP 321
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 516234318 322 QLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMF 358
Cdd:COG2223  322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT 358
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-144 6.27e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 69.23  E-value: 6.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   5 KSVWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFS 84
Cdd:COG2814  207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516234318  85 TTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAL 144
Cdd:COG2814  287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYnSAFFLGGPL 347
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
34-358 7.84e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 66.03  E-value: 7.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  34 EELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMIIP 113
Cdd:cd17324   27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 114 AIYAMAGAVWPNGGRQTFNAIYLAQN-IGVALGAALGGFVAE-FSFNYIFMANLIMYVLFALVAItqFNLEINAKLKRQD 191
Cdd:cd17324  107 IAAAYAADLVPPEKRGRAIGLVFSGLtLGLVLGRPLGGLLGQlLGWRAAFLAIAVLALLAALLLW--RLLPSLPPKKPGS 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 192 NIDLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASFTQSI-HISMSQYSVLWTINGIMILVAQPLirpVIVLLKGN 270
Cdd:cd17324  185 LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPL---AGRLADRG 261
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 271 LKKQMFVGIIIFM-CSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKvGQYQGIVNSASTVGKALGPL 349
Cdd:cd17324  262 GRRALLIALLLLAaALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAA 340

                 ....*....
gi 516234318 350 FGGVLVDMF 358
Cdd:cd17324  341 LGGLVLDHG 349
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
202-364 6.81e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.07  E-value: 6.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 202 SRFVSLILVCVVFAICWIGYIQWETTIASFTQSIHISMSQYSVLWTINGIMILVAQPLIRPVIVLLkgNLKKQMFVGIII 281
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF--GRRRVLLLGLLL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 282 FMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMR 361
Cdd:COG2814   85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                 ...
gi 516234318 362 IMF 364
Cdd:COG2814  165 WVF 167
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
8-360 1.32e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 62.61  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   8 WWLVIGMALNITGASFLWPLNT----IYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFD----KLGGYKT-ILIGT 78
Cdd:COG2211    9 LKEKLAYGLGDLGLNLAFGLLSayllYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPwILIGA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  79 ------FTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQT--FNAIYLAQNIGVALGAALGG 150
Cdd:COG2211   89 iplalsFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTrlSSWRFAFAGLGGLLASVLPP 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 151 FVAEF-----SFNYIFMANLIMYVLFALVAITQFNLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWE 225
Cdd:COG2211  169 PLVAAfggdaALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVA 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 226 TTIASF-TQSIHISMSQYSVLWTINGIMILVAQPLIRPVIVLLkgNLKKQMFVGIIIFMCSFLVTSFA--HQFSIFVIGM 302
Cdd:COG2211  249 ALLLYYfKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF--GKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLA 326
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516234318 303 VILTFGEMFVWPAVPTIANQLAPEGKV-------GQYQGIVNSASTVGKALGPLFGGVLVDMFNM 360
Cdd:COG2211  327 ALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
4-176 7.95e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 60.30  E-value: 7.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   4 PKSVWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLF 83
Cdd:COG2211  227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  84 STTLLNLF--HGWPWYAVWLVLLGFGGGMIIPAIYAMAGAV-----WPNGGRQT---FNAIYLAQNIGVALGAALGGFV- 152
Cdd:COG2211  307 GLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydeWKTGRRREglyFGIFTFAIKLGQALAGALAGLLl 386
                        170       180       190
                 ....*....|....*....|....*....|..
gi 516234318 153 --------AEFSFNYIFMANLIMYVLFALVAI 176
Cdd:COG2211  387 alfgyvagAAQSPSALTGIRLLFFLLPAVLLL 418
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
32-355 4.26e-09

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 57.57  E-value: 4.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  32 MKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMI 111
Cdd:cd17321   22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 112 IPAIYAMAGAVWPNGGRQT-FNAIYLAQNIGVALGAALGGFVAE-FSFNYIFMANLIMyVLFALVAITQFNLEInaklkr 189
Cdd:cd17321  102 MPASLALIAATFPGERRGRaLGLWGAVVGIGAALGPLLGGLLLElFGWRWIFLINVPI-GLVALLLARTFSGAV------ 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 190 qdnidlknqenvsrfVSLILVCVVFAICWIGYIQWETTIASFTQsihismSQYSVLWTINGIMILVAQPLIrpVIVLLKG 269
Cdd:cd17321  175 ---------------LAAFLLGAALGGLLFLLPLYLQGVLGYSP------LQAGLALLPLALAMLVAAPLA--GRLADRF 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 270 NLKKQMFVGIIIFMCSFLVTSFAHQ---FSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKAL 346
Cdd:cd17321  232 GPRLVLVAGLLLTAVGLLLLALLGAdssVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGAL 311
                        330
                 ....*....|
gi 516234318 347 GP-LFGGVLV 355
Cdd:cd17321  312 GVaLLGALLT 321
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
5-176 4.32e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 57.56  E-value: 4.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   5 KSVWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFS 84
Cdd:cd17324  198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  85 TTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPnGGRQTFNAIYL-AQNIGVALGAALGGFV-AEFSFNYIFM 162
Cdd:cd17324  278 LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLaAYNLGGALGAALGGLVlDHGGWAGVGW 356
                        170
                 ....*....|....
gi 516234318 163 ANLIMYVLFALVAI 176
Cdd:cd17324  357 VGAALLLLALLLAL 370
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
7-178 7.70e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 56.85  E-value: 7.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   7 VWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTT 86
Cdd:cd06173  210 LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  87 LLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGR-QTFNAIYLAQNIGVALGAALGGFVAE-FSFNYIFMAN 164
Cdd:cd06173  290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRgRVFSVYNALNSGAMPLGALLAGLLADaLGLSAVFLLA 369
                        170
                 ....*....|....
gi 516234318 165 LIMYVLFALVAITQ 178
Cdd:cd06173  370 GALLLLAALLLLLL 383
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
41-355 7.99e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 56.81  E-value: 7.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  41 TIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTF-------TCLFSTTLLNLFhgwpwyaVWLVLLGFGGGMIIP 113
Cdd:cd17473   35 LLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLlygiggvAGLFLDSLYALL-------ASRALLGIGVAGIMT 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 114 AIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAEFSFNYIFMANLIMYVLFALVAITQFNLEINAK-LKRQD 191
Cdd:cd17473  108 LATALIGDYFEGEERAKMLGLQsAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKsAASPG 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 192 NIDLKNQENVSRFVSLILVCVVFAICWIGYIQwettIASFTQSIHI-SMSQYSVLWTINGIMILVAQPLIRPVIVLLkgN 270
Cdd:cd17473  188 AATAAALPWKRVLPIYFLAFLAMLLFYVIPIQ----LPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRL--G 261
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 271 LKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLF 350
Cdd:cd17473  262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341

                 ....*
gi 516234318 351 GGVLV 355
Cdd:cd17473  342 LGPLV 346
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
31-356 8.52e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 56.81  E-value: 8.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  31 YMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGM 110
Cdd:cd17319   28 TIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAG 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 111 IIPAIYAMAGAVWPNGGRQTFNAIYL-AQNIGVALGAALGGFVAEF-----SFNYIFMANLIMYVLFALVaitqfnlein 184
Cdd:cd17319  108 FFPGAIKALAEWFPARERGRATGLFNsGAPLGAAIGPPLSGWLLLLfgwrwAFIIEGLLGLLLAVLWWFY---------- 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 185 aklkrqdnidlknqenVSRFVSLILVCVVFAICWIGYIQWETTIasFTQSIHISMSQYSVLWTINGIMILVAQPLIRPVI 264
Cdd:cd17319  178 ----------------LRQVWGLALGYFGINYALYGLLTWLPTY--LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLS 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 265 V-LLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVG 343
Cdd:cd17319  240 DrLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLG 319
                        330
                 ....*....|...
gi 516234318 344 KALGPLFGGVLVD 356
Cdd:cd17319  320 GFVAPLLIGYLVD 332
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
20-364 1.42e-08

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 56.05  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  20 GASFLWPLNTIYMKEeLNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTF--TCLFSTTLLNLFHGWPWY 97
Cdd:cd17335   12 ALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLlaAVLFFLSLFFVAQIFWLL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  98 AVWLVLLGFGGGMIIPAIYAMAGAvWPNGGRQTFNAIYLAQNIGVALGAALGGFVAEFSFNYI-FMANLIMYVLFALVAI 176
Cdd:cd17335   91 LLLVILGAFFSAPVVPLVDSITLQ-YLGEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKnYTIAFYVFAVLMLLAL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 177 ---TQFNLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYiqwETTIASFTQSIHISMSQYSVLWTINGIMI 253
Cdd:cd17335  170 llaLKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLI---YSFLFWHLQDLGGSKTLIGLLWTVGVVSE 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 254 LVAQPLIRPVIVLLKgnLKKQMFVGIIIFMCSFLVTSFAHQFSIfVIGMVIL---TFGEMfvWPAVPTIANQLAPEGKVG 330
Cdd:cd17335  247 IPFFFFSSRLIQRFG--HVGLLYLGLLAYVVRWLLYSFLENPWL-VLPIELLhglTFALV--WAAAVSYASAAAPPGLRA 321
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 516234318 331 QYQGIVNSAST-VGKALGPLFGGVLVDMFNMRIMF 364
Cdd:cd17335  322 TAQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTF 356
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
10-148 3.88e-08

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 54.89  E-value: 3.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  10 LVIGMALNitGASFLWPLntiYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLN 89
Cdd:cd17503  188 FLLGLGLF--GAMFLLPL---YLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLA 262
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516234318  90 LFH---GWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAAL 148
Cdd:cd17503  263 FLTpdtSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFnTIRQLGGSIGTAL 325
MFS_1 pfam07690
Major Facilitator Superfamily;
209-364 5.67e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.96  E-value: 5.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  209 LVCVVFAICWIGYIQWETTIASFTQSIHISMSQYSVLWTINGIMILVAQPLIRPVIVLLkgNLKKQMFVGIIIFMCSFLV 288
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF--GRRRVLLIGLLLFALGLLL 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516234318  289 TSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
59-352 1.82e-07

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 52.58  E-value: 1.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  59 LLGGVLFDK-LGGYKTILIGTFTCLFSTTLLNLFHGWPWYA-VWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQT---FNA 133
Cdd:cd17346   58 IIGGWLADKvLGARRTVFIGGILMALGYLLLALSPFSVSMLyLGLALIIVGNGLFKPNISSLVGKLYDENDPRRdsgFSI 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 134 IYLAQNIGVALGAALGGFVAE-FSFNYIFMANLIMyVLFALVAITQFNLEINAKLKrqdnidlknqenVSRFVSLILVCV 212
Cdd:cd17346  138 FYMGINLGAFLAPLLCGTLGDnYGYHYGFGLAAVG-MLLGLLIFLLGRKKLLERKK------------MLAIIILFLFAV 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 213 VFaicWIGYIQWETTIASFTQS--------IHISMSQYSVLwtiNGIMILVAQPLIrPVIVLLKGNLKKQ------MFVG 278
Cdd:cd17346  205 VF---WAIYEQAGTSLALFADEnvdrllggFTIPPSWFQSL---NPLFIILLAPIL-AALWTKLGKRGKDpsiptkFALG 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 279 IIIFMCSFLVTSFAHQFSI---------FVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPL 349
Cdd:cd17346  278 LLLLGLSFLLMVLAASFAGgsgkvsalwLVLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMGLWFLASALGNILAGY 357

                 ...
gi 516234318 350 FGG 352
Cdd:cd17346  358 LAG 360
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
23-356 1.92e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 52.71  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  23 FLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLV 102
Cdd:cd17333   13 ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 103 LLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAALGGFV--AEFSFNYIFMANLIMYVLFALVAitqfn 180
Cdd:cd17333   93 LAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLltSELSWSWAYLIIGLIYLLLAILI----- 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 181 LEINAKLKRQDNIDLKNQENVSRFVS---LILVCVVFAICWIGYIQWETTIASFTQSIHI---SMSQYSVLWTINGIMIL 254
Cdd:cd17333  168 LLTLFPELPSARNPQQSVGAFSASASrllRNPSIILGALALFLYVGAETAFSSWVPSYLVekkHVSDGLAGYLLSGFWVG 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 255 VAQPLIRPVIVLLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPeGKVGQYQG 334
Cdd:cd17333  248 ITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP-YAKGKGTS 326
                        330       340
                 ....*....|....*....|..
gi 516234318 335 IVNSASTVGKALGPLFGGVLVD 356
Cdd:cd17333  327 VLLAAGSIGGAIIPFIMGFIAE 348
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
32-177 2.90e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 51.74  E-value: 2.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  32 MKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMI 111
Cdd:COG0477   40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL 119
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516234318 112 IPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-FSFNYIFMANLIMYVLFALVAIT 177
Cdd:COG0477  120 MPGALALIAELFPARERGRALGLWgAAIGLGLALGPLLGGLLVAaLGWRWIFLINAPLGLLALVLRLR 187
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
5-152 3.08e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 51.79  E-value: 3.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   5 KSVWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFS 84
Cdd:cd17321  168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516234318  85 TTLLNLFH---GWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFV 152
Cdd:cd17321  248 LLLLALLGadsSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILnTARQLGGALGVALLGAL 319
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
45-364 5.62e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 51.00  E-value: 5.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  45 VVLLINSLGMVVGNLL---GGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLG-FGGGMIIPAIYAM-A 119
Cdd:cd17370   35 AVGLIEGLAEALGSLLrlfSGYLSDRTGKRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILErLGKGIRTPPRDALlA 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 120 GAVWPNGGRQTFNAIYLAQNIGVALGAALGGFV---AEFSFNYIFMANLIMYVLfALVAITQFNLEINAKLKRQDNIDLK 196
Cdd:cd17370  115 DATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlylLGGNYRTIFLLAAIPALL-ALLILLFVVKEYPRPPKLRKKSKKT 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 197 NQENVSRfvSLILVCVVFAICWIGYIQWETTIASFtQSIHISMSQYSVLWTI-NGIMILVAQPLIRpviVLLKGNLKKQM 275
Cdd:cd17370  194 SLKKLPK--AFWLYLLAVALFALGNFSFAFLILRA-QELGLSAALIPLLYALfNLVYALAAYPAGR---LSDRIGRKKLL 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 276 FVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLV 355
Cdd:cd17370  268 ILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLW 347

                 ....*....
gi 516234318 356 DMFNMRIMF 364
Cdd:cd17370  348 DLISPSAAF 356
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
202-364 5.77e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 50.58  E-value: 5.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 202 SRFVSLILVCVVFAICWIGYIQWETTIASFTQSIHISMSQYSVLWTINGIMilvaqpliRPVIVLLKGNL------KKQM 275
Cdd:COG0477   11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLG--------RAIGLLLFGRLgdrygrKRVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 276 FVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLV 355
Cdd:COG0477   83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162

                 ....*....
gi 516234318 356 DMFNMRIMF 364
Cdd:COG0477  163 AALGWRWIF 171
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
7-176 7.78e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 50.64  E-value: 7.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   7 VWWLVIGMALN--ITGASFLWpLNTIYMkeELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFS 84
Cdd:COG2807  217 AWLLTLFFGLQslLYYAVVAW-LPPILR--DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLA 293
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  85 TTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNgGRQTFNAIYLAQNIGvALGAALGGFVAEF------SFN 158
Cdd:COG2807  294 GLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRART-PAEAAALSGMAQSVG-YLLAALGPLLVGAlhdatgSWT 371
                        170
                 ....*....|....*...
gi 516234318 159 YIFMANLIMYVLFALVAI 176
Cdd:COG2807  372 AALLLLAALAVLMLVAGL 389
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
8-176 3.58e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 48.37  E-value: 3.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   8 WWLVIGMALNITGASFLWPLNTI---YMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFS 84
Cdd:cd17316  177 RRTLLLILLWFFISFGYYGLTTFlptYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  85 TTLL--NLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTfnAIYLAQNIGVALGAALGGFVAEFSFNYIFM 162
Cdd:cd17316  257 ALPLfyLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRAT--GVGLSYNLGRLGGGGAPPLIALLLASTGGT 334
                        170
                 ....*....|....
gi 516234318 163 ANLIMYVLFALVAI 176
Cdd:cd17316  335 GVPALILALLAIVA 348
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
5-176 4.00e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.58  E-value: 4.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   5 KSVWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTIL-IGTFTCLF 83
Cdd:cd06174  203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLlIGLLLMAL 282
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  84 STTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE--FSFNYI 160
Cdd:cd06174  283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLnTFGFLGGAIGPLLAGFLLAatFGLTGA 362
                        170
                 ....*....|....*.
gi 516234318 161 FMANLIMYVLFALVAI 176
Cdd:cd06174  363 FLVLAVLLLLAAILLL 378
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
210-358 5.22e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.19  E-value: 5.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 210 VCVVFAICWIGYIQWETTIASFTQSIHISMSQYSVLWTINGIMILVAQPLIRPVIvlLKGNLKKQMFVGIIIFMCSFLVT 289
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLA--DRFGRRPVLLLGLLLFALGALLF 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516234318 290 SFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMF 358
Cdd:cd06174   79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL 147
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
26-368 5.94e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.98  E-value: 5.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  26 PLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGtFTCLFSTTLLNLFHGWPWyavWLVLLG 105
Cdd:cd17472   17 PVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFG-LLLFIAGSLLAAYATSIY---GLILGR 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 106 F--GGGMIIPAIYAMAGAVWPNGGR-QTFNAIYLAQNIGVALGAALGGFVAE-FSFNYIFMANLIMyVLFALVAITQFnl 181
Cdd:cd17472   93 AlqGSGAISSVVMALLADLTREENRtKAMALIGASIGIAFAISMVLGPLLAAhLGVSGLFLITAIL-SLVSLLILLFF-- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 182 einakLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASFTqSIHISMSQY----SVLWTINGIMILVAQ 257
Cdd:cd17472  170 -----VPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFY-ILPLLLTQLgggkGQLWKVYLPAILIGF 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 258 PLIRPVIVLL-KGNLKKQMFVGIIIFMCS--FLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQG 334
Cdd:cd17472  244 ILMVPFVIYAeKKGKMKQVFVSSILLIAVgfLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMG 323
                        330       340       350
                 ....*....|....*....|....*....|....
gi 516234318 335 IVNSASTVGKALGPLFGGVLVDMFNMRIMFLTII 368
Cdd:cd17472  324 IYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTIL 357
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
4-175 5.95e-06

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 48.02  E-value: 5.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   4 PKSVWWL-VIGMALNIT-GASFLWplNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTC 81
Cdd:cd17393  198 NRLLLLLgLLALAAALAeGAAADW--SALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLA 275
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  82 LFSTTLLnLFHGWPWYA-VWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAALGGFVAE-FSFNY 159
Cdd:cd17393  276 ALGLLLA-LLAPSVWVAlAGFALMGLGLSVVVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADaTGLRT 354
                        170
                 ....*....|....*.
gi 516234318 160 IFMANLIMYVLFALVA 175
Cdd:cd17393  355 AFLVVALLALLVALLA 370
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
30-176 6.20e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 47.56  E-value: 6.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  30 IYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYK-TILIGTFTCLFSTTLLNLFH---GWPWYAVWLVLLG 105
Cdd:cd17502  192 LYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKpLIVIGTILMSVGAGLLTTLTldtSKWLLIGYLILLG 271
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516234318 106 FGGGMIIPA-IYAMAGAVWPNGGRQTFNAIYLAQNIGVALGAAlggfvaefsFNYIFMANLIMYVLFALVAI 176
Cdd:cd17502  272 LGLGIGFQQpLVAVQNAVPPADVGVATATNTFFRSLGGTLGVA---------ITDVFLVALALAALAFLLSL 334
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
35-176 6.97e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 47.55  E-value: 6.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  35 ELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGgYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMIIPA 114
Cdd:cd17478  224 QRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFG-RRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPV 302
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516234318 115 IYAMAGAVWPnGGRQTFNAIYLAQNIGV-ALGAALGGFVAE-FSFNYIFMANLIMYVLFALVAI 176
Cdd:cd17478  303 TVVLAQELLP-GNVGLASGLMMGLSFGLgGIGAPVLGALADaFGLESVLLILALLPLLGALLAF 365
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
231-364 7.81e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.54  E-value: 7.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 231 FTQSIHISMSQYSVLWTINGIMILVAQPLIRPVIVLLkgNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEM 310
Cdd:cd17324   25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRI--ERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 516234318 311 FVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:cd17324  103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAF 156
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
271-364 8.64e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.57  E-value: 8.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 271 LKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLF 350
Cdd:cd17503   60 TRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTL 139
                         90
                 ....*....|....
gi 516234318 351 GGVLVDMFNMRIMF 364
Cdd:cd17503  140 GGWLTDNLSWRWIF 153
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
4-359 8.80e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.56  E-value: 8.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   4 PKSVWWLVIGM---ALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFT 80
Cdd:COG2807   13 RAGRWLLLLAIvlvALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  81 CLFSTTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNgGRQTFNAIY-LAQNIGVALGAALGGFVAE-FSFN 158
Cdd:COG2807   93 LAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYtAAMGLGAALAAGLTVPLAAaLGWR 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 159 YIFMANLIMYVLFALVAITQFNLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWettIASFTQSIHIS 238
Cdd:COG2807  172 GALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAW---LPPILRDAGLS 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 239 MSQYSVLWTINGIMILVAQPLIrPVIVLLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFViGMVILTFGEMFVWPAVPT 318
Cdd:COG2807  249 AATAGLLLSLFQLAGIPGSLLV-PLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWL-WAVLLGLGQGGLFPLALT 326
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 516234318 319 IANQLAPEGK-VGQYQGIVNSASTVGKALGPLFGGVLVDMFN 359
Cdd:COG2807  327 LIGLRARTPAeAAALSGMAQSVGYLLAALGPLLVGALHDATG 368
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
14-178 1.47e-05

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 47.23  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   14 MALNITGASFLWPLNTI-------YMKEELNKSLTI-AGVVLLINSLGMVVGNLLGGvlfdKLGGYKTIL-------IGT 78
Cdd:PRK08633  234 LWLAIIGLSYFWFISQLaqanfpaYAKEVLGLDNTFqVQYLLAASAIGIGIGSLLAG----RLSGRHIELglvplgaLGL 309
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   79 FTCLFsttLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGR-QTFNAIYLAQNIGVALGAALGGFVA--EF 155
Cdd:PRK08633  310 ALSLF---LLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELgKVLAANNFLQNVGMLLFLALTTLFSglGL 386
                         170       180
                  ....*....|....*....|...
gi 516234318  156 SFNYIFMANLIMYVLFALVAITQ 178
Cdd:PRK08633  387 SPAGLFYLIALVTLIGTLYTLLL 409
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
12-176 1.85e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 46.46  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  12 IGMALNITGASFLWPLntiyMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLF 91
Cdd:cd17475    6 AAASLVAQGIPALAPF----LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  92 HGWPWYAVWLVLLGFGGGMIIPA-IYAMAGAVWPN------GGRQTfnaiylAQNIGVALGAALGGFVAE-FSFNYIFMA 163
Cdd:cd17475   82 GSYPVLLVLLFLVGAGYGSVQPGgGRAIMRWFPPRerglamGIRQT------GVPLGGALAAALLPPLALhYGWRAAFVV 155
                        170
                 ....*....|...
gi 516234318 164 NLIMYVLFALVAI 176
Cdd:cd17475  156 AGLVSILAAVLFW 168
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
59-359 2.13e-05

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 46.10  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  59 LLGGVLFDKLGGYKTILIGTF-TCLFSttLLNLF-HGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQT--FNAI 134
Cdd:cd17476   51 LIFGRLGDIYGHKKMFVIGSFwFAIWS--LIAGFsPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNivFSLF 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 135 YLAQNIGVALGAALGGFVAEF-SFNYIFMANLIMYVLFALVAITQFNLeinaklkrqdnidlknqenvsrfvSLILVCVV 213
Cdd:cd17476  129 GATAPLGFALGGVFGGLFAQLaWWPWIFWFLAILAAIVAVAAIFWTSP------------------------SFIAVLLA 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 214 FAICWIGYIQWETTIASFTQSI-HISMSQYSVLWTINGIMILVAQPLIRPVIVLLKGNLkkQMFVGIIIFMCS--FLVTS 290
Cdd:cd17476  185 VFLGWASFGIWVFYATQYFQNVrGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSY--IMAISMVAFLVGpiLFATM 262
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516234318 291 FAHQ--FSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFN 359
Cdd:cd17476  263 PVHQtyWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGIAGTVETSVN 333
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
26-154 3.98e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 45.30  E-value: 3.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  26 PLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLF--HGWPWYAVWLVL 103
Cdd:cd17318   41 KDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAarGGYGALIVLRIL 120
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 516234318 104 LGFGGGMIIPAIYAMAgAVW--PNGGRQTFNAIYLAQNIGVALGAALGGFVAE 154
Cdd:cd17318  121 QGLAQGVTFPAMHALW-AKWapPLERSRLTSIAYSGSQFGTVIAMPLSGFLCE 172
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
31-359 5.13e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 45.06  E-value: 5.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   31 YMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGM 110
Cdd:TIGR00881  20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGM 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  111 IIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAEFSFNY--IFMANLIMYVLFALVAIT---------- 177
Cdd:TIGR00881 100 GWPPCGRTVTKWFSRSERGTWVSFWnCSHNVGGGLLPPLVLFGIAELYSWhwVFIVPGIIAIIVSLICFLllrdspqscg 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  178 ------QFNLEINAKLKRQDNIDLKNQENV-----SRFVSLILVCVVF-AICWIGYIQWETTIAsfTQSIHIS---MSQY 242
Cdd:TIGR00881 180 lppaeeMPNEEPDGDAEKKEEELTKKQIFLqyvllNKVLWYISLGYVFvYVVRTGILDWSPLYL--TQEKGFSkekASWA 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  243 SVLWTINGIM-ILVAQPLIRPVIVLLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVI--LTFGEMFVWpavPTI 319
Cdd:TIGR00881 258 FTLYELGGLVgTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALgfLVYGPQMLI---GVI 334
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 516234318  320 ANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFN 359
Cdd:TIGR00881 335 ASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
MFS_1 pfam07690
Major Facilitator Superfamily;
5-146 5.66e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.72  E-value: 5.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318    5 KSVWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFS 84
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516234318   85 T---TLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGA 146
Cdd:pfam07690 279 AlglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYnTAGSLGGALGP 344
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
10-179 6.01e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 44.95  E-value: 6.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  10 LVIGMALNITGASFLwPLNTIYMKE---ELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTftcLFSTT 86
Cdd:cd17391  207 FVTTFIIQLANQSIE-PILTLYIRQlmgDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGAL---LASAL 282
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  87 LLNL--FHGWPWYAVWL-VLLGFGGGMIIPAIYAMAGAVWPNGGR-QTFNAIYLAQNIGVALGAALGGFV-AEFSFNYIF 161
Cdd:cd17391  283 LYIPqaFVQTPWQLGILrFLLGLATGGLLPAINSLLAKITPKEVAgRIFGYNQSFQYLGNVAGPLLGSAIaAHFGYRAVF 362
                        170
                 ....*....|....*...
gi 516234318 162 MANLIMYVLFALVAITQF 179
Cdd:cd17391  363 VVTALLVLLNAIWSFIFL 380
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
44-177 1.12e-04

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 43.79  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  44 GVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVW 123
Cdd:cd17393   37 GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAMNAQGVAVE 116
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 516234318 124 PNGGRQTFNAIYLAQNIGVALGAALGGFV--AEFSFNYIFMANLIMYVLFALVAIT 177
Cdd:cd17393  117 RAYGRPIMSSLHAMWSLGGLAGALLGAAAigAGVSPGVHLLAAAVLLLLAALVAIR 172
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
238-364 1.88e-04

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 43.52  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  238 SMSQYSVLWTINGIMILVAqplirpVIVLLKGNL------KKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMF 311
Cdd:TIGR00711  33 GSSLSQVQWVITSYMLANA------ISIPLTGWLakrfgtRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGP 106
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 516234318  312 VWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:TIGR00711 107 LIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIF 159
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
4-119 2.03e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 42.95  E-value: 2.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   4 PKSVWWLVIGMALNITgASFLWPLNT-IYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCL 82
Cdd:cd17473  196 WKRVLPIYFLAFLAML-LFYVIPIQLpFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMA 274
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 516234318  83 FSTTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMA 119
Cdd:cd17473  275 LGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWA 311
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
27-355 2.87e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.59  E-value: 2.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  27 LNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGF 106
Cdd:cd17316   22 APVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGI 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 107 GGGMIIPAIYAMAGAVWPNGGRQTFNAIYLAqniGVALGAALGGFVAeFSFNYIFMANLIMYVLFALVAITQFnleINAK 186
Cdd:cd17316  102 GIGGEYPGASTYVAEFAPSKRRGFALGLLQS---GWALGALLAALVA-SLLIPLLSGDWGWRILFLIGALPAL---LALL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 187 LKRqdnidlknqenvsRFVSLILVCVVFAICWIGYIQWETTIasFTQSIHISMSQYSVLWTINGIMILVAQPLIRPVIVL 266
Cdd:cd17316  175 LRR-------------RTLLLILLWFFISFGYYGLTTFLPTY--LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 267 LkgNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVI--GMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGK 344
Cdd:cd17316  240 I--GRKKTLVIGLILSGILALPLFYLLSGSPTLLllLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGG 317
                        330
                 ....*....|.
gi 516234318 345 ALGPLFGGVLV 355
Cdd:cd17316  318 GGAPPLIALLL 328
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
231-364 4.51e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.16  E-value: 4.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 231 FTQSIHISMSQYSVLWTINGIMILVAQPLIRpvIVLLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEM 310
Cdd:cd17478   22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFG--YLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA 99
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 516234318 311 FVWPAVPTIANQLAPeGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:cd17478  100 AFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLL 152
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
24-364 5.04e-04

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 41.85  E-value: 5.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   24 LWPLNTIYMK-EELNKSLTiaGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIgtFTCLFSTTLLNLFHGWPWYAV--W 100
Cdd:pfam12832  18 LLPYWGLYLRsIGLNPSEI--GLITAILPLTRILAPPIWGWLADRTGKRKAVVR--LASILAAVLFLSVLFIPISLTfwW 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  101 LVLLGFGGGMIIPAIYAMAGAV---WPNGGRQTFNAIYLAQNIGVALGAALGGFVAEF-SFNYIFMANLIMYVLFALVAI 176
Cdd:pfam12832  94 LALLVVLFSFFWNAILPQFEVAtlqHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHySVGLLPSVLFYLFAALMLLSL 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  177 TQFNLEINAKLKRQDNiDLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASFTQSIHISMSQYSVLWTINGIMILVA 256
Cdd:pfam12832 174 LLPLAPPEMEYESKGG-SKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASNTLLGALWALGVVAEIPL 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  257 qpLIRPVIVLLKGNLKKQMFVGIIIFMCSF-LVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGI 335
Cdd:pfam12832 253 --FFYAHRLLRRFGHRNLLIIALLLTALRWlLYAFFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQAL 330
                         330       340       350
                  ....*....|....*....|....*....|
gi 516234318  336 VNSAS-TVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:pfam12832 331 YSGLYfGLGGALGSLIGGQLWDLFGARFTF 360
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
2-155 6.17e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.57  E-value: 6.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318    2 NIPKSVWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTI----AGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIG 77
Cdd:TIGR00895   9 QPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLdpvqLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWS 88
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516234318   78 TFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLaqnIGVALGAALGGFVAEF 155
Cdd:TIGR00895  89 ILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMF---CGYPIGAAVGGFLAGW 163
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
10-176 6.17e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 41.41  E-value: 6.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  10 LVIGMALNITGASFLWPLNTIYMkeeLNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLN 89
Cdd:cd17504  189 AGFGMFMVFQLLPQLLQLPTPTG---FGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLA 265
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  90 LFHGWPWYAVW-LVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFV--------------A 153
Cdd:cd17504  266 LLHSSLWALVVaLLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNtVLRTIGSAIGPAIAGAIlttytvsitsggvpT 345
                        170       180
                 ....*....|....*....|...
gi 516234318 154 EFSFNYIFMANLIMYVLFALVAI 176
Cdd:cd17504  346 EGAYVLAFLIGAALALAALLLSL 368
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
10-364 6.42e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.39  E-value: 6.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  10 LVIGMALNITGASFLWPLNTIyMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLN 89
Cdd:cd17478    1 LSLGHFLNDFYQGFLPALLPL-LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  90 LFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVwPNGGRQTFNAIY-LAQNIGVALGAALGGFVAEFSFNY-IFMANLIM 167
Cdd:cd17478   80 FAPNYWLLLLLVALAGIGSAAFHPEGARLASQA-AGGRRGLAMSIFsVGGNLGFALGPLIAAALVALFGGLgLLILLIIP 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 168 YVLFALVAITQFNLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWigyiqwettiasftqsIHISMSQY-SVLW 246
Cdd:cd17478  159 GLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSW----------------VLSSLTTFlPFYL 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 247 TINGIMILVAQPLIrpVIVLL--------------KGNLKKQMFVGIIIFMCSFLVTSFAHQFsIFVIGMVILTFGEMFV 312
Cdd:cd17478  223 VQRGYSLVFAGLLL--SLFLFagaigtliggplsdRFGRRRVIIASLLLAAPFLLLFLLTPGI-WSYILLVLAGFLLFAS 299
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 516234318 313 WPAVPTIANQLAPeGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:cd17478  300 FPVTVVLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVL 350
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
32-153 6.75e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.42  E-value: 6.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  32 MKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGgYKTILIGTFTCLFSTTLLNLFHGWPW-YAVWLVLLGFGGGM 110
Cdd:cd17365   25 LAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFG-RKRVLLVSVALFGLFTLLTAFAQSVLqLALLRFLTGLGLGA 103
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 516234318 111 IIPAIYAMAGAVWPNGGRQTFNAIYLAqniGVALGAALGGFVA 153
Cdd:cd17365  104 AMPNAITLVSEYAPARRRSLAVTLMFC---GYPLGAALGGFLA 143
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
202-364 9.51e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.02  E-value: 9.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 202 SRFVSLILVCVVFAICWIGYIQWETTIASFTQSIHISMSQYSVLWTINGIMILVAQPLIRPVIVLLKGnlKKQMFVGIII 281
Cdd:COG2223    2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP--RRVLLIGLLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 282 FMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMR 361
Cdd:COG2223   80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159

                 ...
gi 516234318 362 IMF 364
Cdd:COG2223  160 NAF 162
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
10-358 1.55e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.23  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  10 LVIGMALNITGASFLWPLNTIYMKEElNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLN 89
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  90 LFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAEFSFNYIFMANLIMy 168
Cdd:cd17477   80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYsTVLGLGFALGPLLLALVGTAGALPFLIAAVLL- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 169 vLFALVAITqfnleinakLKRQDNIDLKNQENVSRFVSLILVCVVFAICWI-GYIqwETTIAS----FTQSIHISMSQYS 243
Cdd:cd17477  159 -LLALVPLL---------LTRRAAPEIEEAESISLRRLLRIAPLALLGAFVaGFL--EGAFYSllplYGLRLGLSVAQAA 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 244 VLWTINGIMILVAQPlirPVIVLLK--GNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIAN 321
Cdd:cd17477  227 LLLAAFVLGGLLLQW---PLGWLADrfDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAG 303
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 516234318 322 QLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMF 358
Cdd:cd17477  304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAF 340
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
202-355 1.61e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.22  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 202 SRFVSLILVCVVFAICWIGYIQWETTIASFTQSIHISMSQYSVLWTINGIMILVAQPLIRPVIVLLkgNLKKQMFVGIII 281
Cdd:COG0738    5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRF--GYKRGLLLGLLL 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516234318 282 FMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKvGQYQGIVNSASTVGKALGPLFGGVLV 355
Cdd:COG0738   83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLI 155
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
52-195 1.71e-03

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 40.44  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   52 LGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYAMAGAVWPNGGRQTF 131
Cdd:TIGR00711  48 LANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRA 127
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516234318  132 NAIY-LAQNIGVALGAALGGFVAE-FSFNYIFMANLIMYVLFALVAITQFNLEINAKLKRQDNIDL 195
Cdd:TIGR00711 128 MAIWgLTVLVAPALGPTLGGWIIEnYHWRWIFLINVPIGIIVVVVAFFILPRDKPAASENFDFLGL 193
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
10-364 2.77e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.45  E-value: 2.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  10 LVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLN 89
Cdd:cd17471    1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  90 LF--HGWPWYAVWLVLLGFGGgMIIPAIYAMA--GAVWPNGGRQTF------NAIYLAQNIGVALGAALggfVAEFSFNY 159
Cdd:cd17471   81 AFlrNYWVLLLVGVVLLSLGA-AAFPQLFALAreYADRSSGRDATLfnsvlrAAFSLAWVIGPPLAFLL---LDVLGFTG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 160 IFmanLIMYVLFALVAITQFNLEINAKLKRQDNIDLKNQENVSRFVSLILVCVVFAICWIGYIQWETTIASF-TQSIHIS 238
Cdd:cd17471  157 LF---LLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYvTNELGGS 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 239 MSQYSVLWTING-----IMILVAqplirpvIVLLKGNLKKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVW 313
Cdd:cd17471  234 ESWVGLLFGLAAaleipIMLLAG-------LLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITA 306
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 516234318 314 PAVPTIANQLAPeGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:cd17471  307 GLGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVF 356
PRK14995 PRK14995
SmvA family efflux MFS transporter;
12-175 2.80e-03

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 39.71  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  12 IGMALNITGASFLWPLNtIYmkeelnkSLTIAGVVLLINSLGMVVG----NLLGGVLFDklggyktilIGTFTCLFSTTl 87
Cdd:PRK14995  32 LSMTLGASGNELLWIID-IY-------SLVMAGMVLPMGALGDRIGfkrlLMLGGTLFG---------LASLAAAFSPT- 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  88 lnlfhgwpwyAVWLV----LLGFGGGMIIPAIYA-------------MAGAVWPNGGrqtfnaiylaqNIGVALGAALGG 150
Cdd:PRK14995  94 ----------ASWLIatraLLAIGAAMIVPATLAgiratfteekqrnMALGVWAAVG-----------SGGAAFGPLVGG 152
                        170       180
                 ....*....|....*....|....*..
gi 516234318 151 FVAE-FSFNYIFMANL-IMYVLFALVA 175
Cdd:PRK14995 153 ILLEhFYWGSVFLINVpIVLVVMGLTA 179
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
5-176 2.97e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 39.52  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   5 KSVWWLVIGMALNITGASFLWPLNTIYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKT-ILIGTFTCLF 83
Cdd:cd17353  213 PTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTlSIAFLIQGVA 292
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  84 STTLLNLFHGWPWYAVWLVLLGFGGGMIIpaiyamagAVWPNGGRQTFNAIYLAQNIGV-----ALGAALGGFVAEF--- 155
Cdd:cd17353  293 MFLLPFIGSVAVLFVLGVALIGFCYGGGF--------ALFPALTADFFGTKNAGTNYGLlytakGVGGLIGPIIAAYvly 364
                        170       180
                 ....*....|....*....|...
gi 516234318 156 --SFNYIFMANLIMYVLFALVAI 176
Cdd:cd17353  365 tgGYNAAFIIAAALSLVALALAL 387
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
32-347 4.02e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.10  E-value: 4.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  32 MKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMI 111
Cdd:cd17503   22 IMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 112 IPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVALGAALGGFVAE-FSFNYIFMANLIMyVLFALVAITQFNLEInaklkr 189
Cdd:cd17503  102 IPLAQTILLRIYPPEKRGAAMGLVgLVILLAPAIGPTLGGWLTDnLSWRWIFYINLPI-GILALLLAPLLDLRL------ 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 190 qdnidLKNQenvsrfvSLILVCVVFAICWIGYIQWETTIASFTQSIHismsQYSVLWTinGIMIL---VAQPLIRPVIVL 266
Cdd:cd17503  175 -----FKDR-------NFTLGLLLSFLLGLGLFGAMFLLPLYLQNVL----GYSAFES--GLVLApggLASAILSPLVGR 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 267 L--KGNLKKQMFVGIIIFMCSFLVTSFAH---QFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSAST 341
Cdd:cd17503  237 LldKFGPRLLLLAGLLLLALGTLLLAFLTpdtSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQ 316

                 ....*.
gi 516234318 342 VGKALG 347
Cdd:cd17503  317 LGGSIG 322
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
232-364 4.49e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.69  E-value: 4.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 232 TQSIHISMSQysVLWTINGIMILVAqplirpVIVLLKGNL-----KKQMF-VGIIIFMCSFLVTSFAHQFSIFVIGMVIL 305
Cdd:cd17321   23 ARDLGASPSQ--LQWVVNAYLLAFA------ALLLLAGRLgdrfgRKRVFlIGLALFGLASLLCALAPSLAFLIAARALQ 94
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 516234318 306 TFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFGGVLVDMFNMRIMF 364
Cdd:cd17321   95 GIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIF 153
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
9-117 5.09e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 39.19  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318    9 WLVIGMALNITGAS-----FLWPlntiYMKEELNKSLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLF 83
Cdd:TIGR01299 169 FFVLGLALMADGVEvfvvgFVLP----SAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGF 244
                          90       100       110
                  ....*....|....*....|....*....|....
gi 516234318   84 STTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYA 117
Cdd:TIGR01299 245 FAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFS 278
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
41-173 5.33e-03

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 38.75  E-value: 5.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  41 TIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTFTCLFSTTLLNLFHGWPWYAVW------LVLLGFGGGMIIPA 114
Cdd:cd17485  243 QIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWvlllasLALLHLVGGMITTA 322
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516234318 115 IYAMAGAvWPNGGRQT--FNAIYLAQNIGVALGAALGGFVAE---FSFNYIFMANLIMYVLFAL 173
Cdd:cd17485  323 LFTLMMD-CSQQAQAGtdYTLLATVEVLGKLLFGSLAGFLADhlgYAAAFLLFAILSALSVLLL 385
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
272-364 5.96e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 38.31  E-value: 5.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 272 KKQMFVGIIIFMCSFLVTSFAHQFSIFVIGMVILTFGEMFVWPAVPTIANQLAPEGKVGQYQGIVNSASTVGKALGPLFG 351
Cdd:cd17502   60 KWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIG 139
                         90
                 ....*....|...
gi 516234318 352 GVLVDMFNMRIMF 364
Cdd:cd17502  140 GAFTDHLSWRWCF 152
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
9-179 7.19e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 38.36  E-value: 7.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318   9 WLVIGMALNITGASF--LWPLNTIYMKEELNKSLTIaGVVLLINSLGMVVGNLLGGVLF-DKLGGYKTILIGtFTCLFST 85
Cdd:cd17490  197 LFFSLLAILQQMITFstTFGFTPLIAKQLGASSFQL-GLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIG-FLLLGAY 274
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  86 TLLNLFHGWPWYAVWL-VLLGFGGGMIIPAIYAMAGAVWPNGGRQT----FNAIYlaqNIGVALGAALGGFVAE-FSFNY 159
Cdd:cd17490  275 CFLIPFAPNLTLLYLLqALNGFGTGILFPLLMSLSIEGVPAEQRSTamgfFQAIY---ALGMFLGPVLVGIISEaFGLQT 351
                        170       180
                 ....*....|....*....|
gi 516234318 160 IFMANLIMYVLFALVAITQF 179
Cdd:cd17490  352 GFFVIGVIALLAAILSLAYY 371
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
39-174 7.85e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 37.95  E-value: 7.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318  39 SLTIAGVVLLINSLGMVVGNLLGGVLFDKLGGYKTILIGTF-TCLFSTTLLNLFHGWPWYAVWLVLLGFGGGMIIPAIYA 117
Cdd:cd17365  204 SLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFAlGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYA 283
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516234318 118 MAGAVWPNGGRQTFNAIYLA-QNIGVALGAALGGFV--AEFSFNYIFMANLIMYVLFALV 174
Cdd:cd17365  284 LAARFYPTEVRATGVGWALGvGRLGAILGPLLGGLLlaAGLGPESVFLALAIPAALGALA 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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