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Conserved domains on  [gi|516289465|ref|WP_017692772|]
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MULTISPECIES: 4Fe-4S dicluster domain-containing protein [Enterobacter]

Protein Classification

4Fe-4S dicluster domain-containing protein( domain architecture ID 11586809)

4Fe-4S dicluster domain-containing protein similar to Escherichia coli formate hydrogenlyase subunit 2 (HycB), a probable electron transfer protein for hydrogenase 3

Gene Ontology:  GO:0051539|GO:0009061|GO:0046872|GO:0019645
SCOP:  3000020

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 4-167 1.61e-60

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


:

Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 185.54  E-value: 1.61e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   4 FVIADSTVCIGCRTCEAACSETHR--------LHGLQSMPRLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITRVDGAV 75
Cdd:cd10554    1 FVIADPDKCIGCRTCEVACAAAHSgkgifeagTDGLPFLPRLRVVKTGEVTAPVQCRQCEDAPCANVCPVGAISQEDGVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  76 QLNESLCVSCKLCGIACPFGAIEFSGSRPLHIpanantpkappappaparvstllDWVPGIRAVAVKCDLCSFDEQGPAC 155
Cdd:cd10554   81 QVDEERCIGCKLCVLACPFGAIEMAPTTVPGV-----------------------DWERGPRAVAVKCDLCAGREGGPAC 137

                        170
                 ....*....|..
gi 516289465 156 VRTCPTRALVLV 167
Cdd:cd10554  138 VEACPTKALTLV 149
 
Name Accession Description Interval E-value
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 4-167 1.61e-60

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 185.54  E-value: 1.61e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   4 FVIADSTVCIGCRTCEAACSETHR--------LHGLQSMPRLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITRVDGAV 75
Cdd:cd10554    1 FVIADPDKCIGCRTCEVACAAAHSgkgifeagTDGLPFLPRLRVVKTGEVTAPVQCRQCEDAPCANVCPVGAISQEDGVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  76 QLNESLCVSCKLCGIACPFGAIEFSGSRPLHIpanantpkappappaparvstllDWVPGIRAVAVKCDLCSFDEQGPAC 155
Cdd:cd10554   81 QVDEERCIGCKLCVLACPFGAIEMAPTTVPGV-----------------------DWERGPRAVAVKCDLCAGREGGPAC 137

                        170
                 ....*....|..
gi 516289465 156 VRTCPTRALVLV 167
Cdd:cd10554  138 VEACPTKALTLV 149
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
1-167 5.38e-55

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 171.38  E-value: 5.38e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   1 MNRFVIADSTVCIGCRTCEAACSETHR-LHGLQSMPRLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITRVDGAVQLNE 79
Cdd:COG1142    1 MNKFIIADPEKCIGCRTCEAACAVAHEgEEGEPFLPRIRVVRKAGVSAPVQCRHCEDAPCAEVCPVGAITRDDGAVVVDE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  80 SLCVSCKLCGIACPFGAIEFSGSRPlhipanantpkappappaparvstlldwvpgiRAVAVKCDLCSFDEQGPACVRTC 159
Cdd:COG1142   81 EKCIGCGLCVLACPFGAITMVGEKS--------------------------------RAVAVKCDLCGGREGGPACVEAC 128


                 ....*...
gi 516289465 160 PTRALVLV 167
Cdd:COG1142  129 PTGALRLV 136
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 1-183 1.70e-44

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 156.45  E-value: 1.70e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   1 MNRFVIADSTVCIGCRTCEAAC-----SETHRLHGLQSMPRLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITRVDGAV 75
Cdd:PRK12769   1 MNRFIMANSQQCLGCHACEIACvmahnDEQHVLSQHHFHPRITVIKHQQQRSAVTCHHCEDAPCARSCPNGAISHVDDSI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  76 QLNESLCVSCKLCGIACPFGAIEFSGSrplhiPANANTpkappappaparvstlldwvpgIRAVAVKCDLCSFDEQGPAC 155
Cdd:PRK12769  81 QVNQQKCIGCKSCVVACPFGTMQIVLT-----PVAAGK----------------------VKATAHKCDLCAGRENGPAC 133

                        170       180
                 ....*....|....*....|....*...
gi 516289465 156 VRTCPTRALVLVNIRDIARTSKRKRELT 183
Cdd:PRK12769 134 VENCPADALQLVTEQALSGMAKSRRLRT 161
FDH-beta TIGR01582
formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit ...
 8-165 4.43e-13

formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


Pssm-ID: 273705 [Multi-domain]  Cd Length: 283  Bit Score: 66.09  E-value: 4.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465    8 DSTVCIGCRTCEAACSETHRLH---------GLQSMPRL-----RVMR-NEKESAPQL--------CHHCEDAPCAGVCP 64
Cdd:TIGR01582  27 DVSSCIGCKACQAACQEWNDTTppilsrkvgGYQNPPDLlpetfTLMRfKEGEESDGLewlirkdgCMHCREPGCLKACP 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   65 VNA--ITRVDGAVQLNESLCVSCKLCGIACPFGAiefsgsrPLHIPANANtpkappappaparvstlldwvpgiravAVK 142
Cdd:TIGR01582 107 APGaiIQYQNGIVDFDHSKCIGCGYCIVGCPFNI-------PRYDKVDNR---------------------------PYK 152

                         170       180
                  ....*....|....*....|....*..
gi 516289465  143 CDLCSfDE----QGPACVRTCPTRALV 165
Cdd:TIGR01582 153 CTLCI-DRvsvgQEPACVKTCPTNAIS 178
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 48-166 1.52e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 58.41  E-value: 1.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   48 PQLCHHCEDAPCAGVCPVNAITR--VDGAVQLNESLCVSCKLCGIACPFGAIEFsgsrplhipanantpkappappapar 125
Cdd:pfam13247   7 PEQCRHCLNPPCKASCPVGAIYKdeETGAVLLDEKTCRGWRECVSACPYNIPRY-------------------------- 60

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 516289465  126 vstllDWVPGiraVAVKCDLC-SFDEQG--PACVRTCPTRALVL 166
Cdd:pfam13247  61 -----NDETG---KAEKCDMCyDRVEAGllPACVQTCPTGAMNF 96
 
Name Accession Description Interval E-value
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 4-167 1.61e-60

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 185.54  E-value: 1.61e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   4 FVIADSTVCIGCRTCEAACSETHR--------LHGLQSMPRLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITRVDGAV 75
Cdd:cd10554    1 FVIADPDKCIGCRTCEVACAAAHSgkgifeagTDGLPFLPRLRVVKTGEVTAPVQCRQCEDAPCANVCPVGAISQEDGVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  76 QLNESLCVSCKLCGIACPFGAIEFSGSRPLHIpanantpkappappaparvstllDWVPGIRAVAVKCDLCSFDEQGPAC 155
Cdd:cd10554   81 QVDEERCIGCKLCVLACPFGAIEMAPTTVPGV-----------------------DWERGPRAVAVKCDLCAGREGGPAC 137

                        170
                 ....*....|..
gi 516289465 156 VRTCPTRALVLV 167
Cdd:cd10554  138 VEACPTKALTLV 149
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
1-167 5.38e-55

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 171.38  E-value: 5.38e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   1 MNRFVIADSTVCIGCRTCEAACSETHR-LHGLQSMPRLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITRVDGAVQLNE 79
Cdd:COG1142    1 MNKFIIADPEKCIGCRTCEAACAVAHEgEEGEPFLPRIRVVRKAGVSAPVQCRHCEDAPCAEVCPVGAITRDDGAVVVDE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  80 SLCVSCKLCGIACPFGAIEFSGSRPlhipanantpkappappaparvstlldwvpgiRAVAVKCDLCSFDEQGPACVRTC 159
Cdd:COG1142   81 EKCIGCGLCVLACPFGAITMVGEKS--------------------------------RAVAVKCDLCGGREGGPACVEAC 128


                 ....*...
gi 516289465 160 PTRALVLV 167
Cdd:COG1142  129 PTGALRLV 136
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 1-183 1.70e-44

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 156.45  E-value: 1.70e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   1 MNRFVIADSTVCIGCRTCEAAC-----SETHRLHGLQSMPRLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITRVDGAV 75
Cdd:PRK12769   1 MNRFIMANSQQCLGCHACEIACvmahnDEQHVLSQHHFHPRITVIKHQQQRSAVTCHHCEDAPCARSCPNGAISHVDDSI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  76 QLNESLCVSCKLCGIACPFGAIEFSGSrplhiPANANTpkappappaparvstlldwvpgIRAVAVKCDLCSFDEQGPAC 155
Cdd:PRK12769  81 QVNQQKCIGCKSCVVACPFGTMQIVLT-----PVAAGK----------------------VKATAHKCDLCAGRENGPAC 133

                        170       180
                 ....*....|....*....|....*...
gi 516289465 156 VRTCPTRALVLVNIRDIARTSKRKRELT 183
Cdd:PRK12769 134 VENCPADALQLVTEQALSGMAKSRRLRT 161
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 1-182 1.16e-35

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 123.52  E-value: 1.16e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   1 MNRFVIaDSTVCIGCRTCEAACSETHRLHglQSMPRLRVMRNEKESAPQ--------LCHHCEDAPCAGVCPVNAIT-RV 71
Cdd:COG0437    5 RYGMVI-DLTKCIGCRACVVACKEENNLP--VGVTWRRVRRYEEGEFPNvewlfvpvLCNHCDDPPCVKVCPTGATYkRE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  72 DGAVQLNESLCVSCKLCGIACPFGAIEFSGSRPlhipanantpkappappaparvstlldwvpgiraVAVKCDLCS---F 148
Cdd:COG0437   82 DGIVLVDYDKCIGCRYCVAACPYGAPRFNPETG----------------------------------VVEKCTFCAdrlD 127

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 516289465 149 DEQGPACVRTCPTRALVLVNIRDI-ARTSKRKREL 182
Cdd:COG0437  128 EGLLPACVEACPTGALVFGDLDDPeSEVSKRLAEL 162
PRK10330 PRK10330
electron transport protein HydN;
1-180 1.16e-35

electron transport protein HydN;


Pssm-ID: 182382 [Multi-domain]  Cd Length: 181  Bit Score: 123.46  E-value: 1.16e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   1 MNRFVIADSTVCIGCRTCEAACSETHR-------LHGLQSMPRLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITRVDG 73
Cdd:PRK10330   1 MNRFIIADASKCIGCRTCEVACVVSHQenqdcasLTPETFLPRIHVIKGVNVSTATVCRQCEDAPCANVCPNGAISRDKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  74 AVQLNESLCVSCKLCGIACPFGAIEFSgSRPLhipanantpkappappapARVSTLLDWVPGIRAVAVKCDLCSFDEQGP 153
Cdd:PRK10330  81 FVHVMQERCIGCKTCVVACPYGAMEVV-VRPV------------------IRNSGAGLNVRAEKAEANKCDLCNHREDGP 141

                        170       180
                 ....*....|....*....|....*..
gi 516289465 154 ACVRTCPTRALVLVNIRDIARTSKRKR 180
Cdd:PRK10330 142 ACMAACPTHALICVDRNKLEQLSAEKR 168
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 1-189 5.00e-35

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 130.15  E-value: 5.00e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   1 MNRFVIADSTVCIGCRTCEAACSETHR-----LHGLQSMPRLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITRVDGAV 75
Cdd:PRK12809   1 MNKFIAAEAAECIGCHACEIACAVAHNqenwpLSHSDFRPRIHVVGKGQAANPVACHHCNNAPCVTACPVNALTFQSDSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  76 QLNESLCVSCKLCGIACPFGAIEFsgsrplhipanantpkappappaparvstlldwvpgIRAVAVKCDLCSFDEQGP-A 154
Cdd:PRK12809  81 QLDEQKCIGCKRCAIACPFGVVEM------------------------------------VDTIAQKCDLCNQRSSGTqA 124

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 516289465 155 CVRTCPTRALVLVnirDIARTSKRKRELTINTDVG 189
Cdd:PRK12809 125 CIEVCPTQALRLM---DDKGLQQIKVARQRKTAAG 156
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 8-167 8.93e-33

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 114.79  E-value: 8.93e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   8 DSTVCIGCRTCEAACSETHRL---HGLQSMPRLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITRV-DGAVQLNESLCV 83
Cdd:cd04410    4 DLDRCIGCGTCEVACKQEHGLrpgPDWSRIKVIEGGGLERAFLPVSCMHCEDPPCVKACPTGAIYKDeDGIVLIDEDKCI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  84 SCKLCGIACPFGAIEFsgsrplhipanantpkappappaparvstllDWVPGiraVAVKCDLC---SFDEQGPACVRTCP 160
Cdd:cd04410   84 GCGSCVEACPYGAIVF-------------------------------DPEPG---KAVKCDLCgdrLDEGLEPACVKACP 129


                 ....*..
gi 516289465 161 TRALVLV 167
Cdd:cd04410  130 TGALTFG 136
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 5-167 3.92e-31

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 110.36  E-value: 3.92e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   5 VIADSTVCIGCRTCEAACSETHRLHGLQSMPRLRVMRNEKE--SAPQLCHHCEDAPCAGVCPVNAITR--VDGAVQLNES 80
Cdd:cd10550    1 LVVDPEKCTGCRTCELACSLKHEGVFNPSLSRIRVVRFEPEglDVPVVCRQCEDAPCVEACPVGAISRdeETGAVVVDED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  81 LCVSCKLCGIACPFGAIEFsgsrplhipanantpkappappaparvstllDWVpgiRAVAVKCDLCSFDeqgPACVRTCP 160
Cdd:cd10550   81 KCIGCGMCVEACPFGAIRV-------------------------------DPE---TGKAIKCDLCGGD---PACVKVCP 123


                 ....*..
gi 516289465 161 TRALVLV 167
Cdd:cd10550  124 TGALEFV 130
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 5-167 7.78e-29

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 104.65  E-value: 7.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   5 VIADSTVCIGCRTCEAACSETHR---------LHGLQSMPRLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITR--VDG 73
Cdd:cd10563    2 IFIDEEKCLGCKLCEVACAVAHSkskdlikakLEKERPRPRIRVEESGGRSFPLQCRHCDEPPCVKACMSGAMHKdpETG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  74 AVQLNESLCVSCKLCGIACPFGAIEFSGSRPlhipanantpkappappaparvstlldwvpgiraVAVKCDLCsFDEQGP 153
Cdd:cd10563   82 IVIHDEEKCVGCWMCVMVCPYGAIRPDKERK----------------------------------VALKCDLC-PDRETP 126

                        170
                 ....*....|....
gi 516289465 154 ACVRTCPTRALVLV 167
Cdd:cd10563  127 ACVEACPTGALVLE 140
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 5-175 7.80e-29

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 104.66  E-value: 7.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   5 VIADSTVCIGCRTCEAACSETHRLHglqsmPRLRVMR-NEKESAPQLCHHCEDAPCAGVCPVNAITR-VDGAVQLNESLC 82
Cdd:cd16374    1 VYVDPERCIGCRACEIACAREHSGK-----PRISVEVvEDLASVPVRCRHCEDAPCMEVCPTGAIYRdEDGAVLVDPDKC 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  83 VSCKLCGIACPFGAIEFSGSRPlhipanantpkappappaparvstlldwvpgiraVAVKCDLCS---FDEQGPACVRTC 159
Cdd:cd16374   76 IGCGMCAMACPFGVPRFDPSLK----------------------------------VAVKCDLCIdrrREGKLPACVEAC 121

                        170
                 ....*....|....*.
gi 516289465 160 PTRALVLVNIRDIART 175
Cdd:cd16374  122 PTGALKFGDIEELLKE 137
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 8-164 9.25e-29

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 104.57  E-value: 9.25e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   8 DSTVCIGCRTCEAACSETHRLhgLQSMPRLRVMRNEKESAPQL--------CHHCEDAPCAGVCPVNAIT-RVDGAVQLN 78
Cdd:cd16371    5 DQERCIGCKACEIACKDKNDL--PPGVNWRRVYEYEGGEFPEVfayflsmsCNHCENPACVKVCPTGAITkREDGIVVVD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  79 ESLCVSCKLCGIACPFGAIEFSGSRPlhipanantpkappappaparvstlldwvpgiraVAVKCDLCsFD--EQG--PA 154
Cdd:cd16371   83 QDKCIGCGYCVWACPYGAPQYNPETG----------------------------------KMDKCDMC-VDrlDEGekPA 127

                        170
                 ....*....|
gi 516289465 155 CVRTCPTRAL 164
Cdd:cd16371  128 CVAACPTRAL 137
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 4-171 3.23e-27

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 101.84  E-value: 3.23e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   4 FVIaDSTVCIGCRTCEAACSETHRLhgLQSMPRLRVMRNEKESA--------PQLCHHCEDAPCAGVCPVNAIT-RVDGA 74
Cdd:cd10551    1 MVI-DLRKCIGCGACVVACKAENNV--PPGVFRNRVLEYEVGEYpnvkrtflPVLCNHCENPPCVKVCPTGATYkREDGI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  75 VQLNESLCVSCKLCGIACPFGAIEFSGSRPLHIPANantpkappappaparvstlldwVPGIRAVAVKCDLCS-FDEQG- 152
Cdd:cd10551   78 VLVDYDKCIGCRYCMAACPYGARYFNPEEPHEFGEV----------------------PVRPKGVVEKCTFCYhRLDEGl 135

                        170       180
                 ....*....|....*....|
gi 516289465 153 -PACVRTCPTRALVLVNIRD 171
Cdd:cd10551  136 lPACVEACPTGARIFGDLDD 155
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 8-165 9.53e-25

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 95.74  E-value: 9.53e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   8 DSTVCIGCRTCEAACSETHRL--------HGLQSMPRL------RVMRNEKESAP-------QLCHHCEDAPCAGVCPVN 66
Cdd:cd10561    5 DTTRCIGCRACEVACKEWNGLpaedtafgPGWDNPRDLsaktytVIKRYEVETGGkgfvfvkRQCMHCLDPACVSACPVG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  67 AITRV-DGAVQLNESLCVSCKLCGIACPFGAIEFSGSRPLhipanantpkappappaparvstlldwvPGIRavavKCDL 145
Cdd:cd10561   85 ALRKTpEGPVTYDEDKCIGCRYCMVACPFNIPKYEWDSAN----------------------------PKIR----KCTM 132

                        170       180
                 ....*....|....*....|....
gi 516289465 146 CsFD--EQG--PACVRTCPTRALV 165
Cdd:cd10561  133 C-YDrlKEGkqPACVEACPTGALL 155
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 8-165 2.24e-20

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 84.75  E-value: 2.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   8 DSTVCIGCRTCEAACSETHRLH--------GLQSMPRLR-----VMR-NEKESAPQL--------CHHCEDAPCAGVCP- 64
Cdd:cd10558    5 DVSKCIGCKACQVACKEWNDLRaevghnvgTYQNPADLSpetwtLMKfREVEDNGKLewlirkdgCMHCADPGCLKACPs 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  65 VNAI-TRVDGAVQLNESLCVSCKLCGIACPFgaiefsgsrplHIPanantpkappappapaRVSTLLdwvpgirAVAVKC 143
Cdd:cd10558   85 PGAIvQYANGIVDFQSDKCIGCGYCIKGCPF-----------DIP----------------RISKDD-------NKMYKC 130

                        170       180
                 ....*....|....*....|....*
gi 516289465 144 DLCS---FDEQGPACVRTCPTRALV 165
Cdd:cd10558  131 TLCSdrvSVGLEPACVKTCPTGALH 155
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 12-171 3.15e-20

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 82.36  E-value: 3.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  12 CIGCRTCEAACSETH----RLHglqsmprLRVMRNEKESAPQLCHHCEDAPCAGVCPVNAITRVD-GAVQLNESlCVSCK 86
Cdd:cd16367   21 CIRCDNCEKACADTHdghsRLD-------RNGLRFGNLLVPTACRHCVDPVCMIGCPTGAIHRDDgGEVVISDA-CCGCG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  87 LCGIACPFGAIEFsgsrplhipanantpkappappaparvstlldwvpgirAVAVKCDLCSfDEQGPACVRTCPTRALVL 166
Cdd:cd16367   93 NCASACPYGAIQM--------------------------------------VRAVKCDLCA-GYAGPACVSACPTGAAIR 133


                 ....*
gi 516289465 167 VNIRD 171
Cdd:cd16367  134 VNPEE 138
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 8-165 3.89e-20

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 82.45  E-value: 3.89e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   8 DSTVCIGCRTCEAACSE--------THRLHGLQSMPRL-----RVMR-NEKE---------SAPQLCHHCEDAPCAGVCP 64
Cdd:cd16366    4 DTSRCTGCRACQVACKQwnglpaekTEFTGSYQNPPDLtahtwTLVRfYEVEkpggdlswlFRKDQCMHCTDAGCLAACP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  65 VNAITRVD-GAVQLNESLCVSCKLCGIACPFGAIEFSGSRPlhipanantpkappappaparvstlldwvpgiraVAVKC 143
Cdd:cd16366   84 TGAIIRTEtGTVVVDPETCIGCGYCVNACPFDIPRFDEETG----------------------------------RVAKC 129

                        170       180
                 ....*....|....*....|....*.
gi 516289465 144 DLCsFDEQG----PACVRTCPTRALV 165
Cdd:cd16366  130 TLC-YDRISnglqPACVKTCPTGALT 154
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 8-164 9.54e-20

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 81.58  E-value: 9.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   8 DSTVCIGCRTCEAACSETHRLHG--------LQSMPRL--------RVMRNEKESAP-------QLCHHCEDAPCAGVCP 64
Cdd:cd10562    4 DTSKCTACRGCQVACKQWNQLPAektpftgsYQNPPDLtpntwtliRFYEHEEDNGGirwlfrkRQCMHCTDAACVKVCP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  65 VNAITRVD-GAVQLNESLCVSCKLCGIACPFGAIEFSGSRPlhipanantpkappappaparvstlldwvpgiraVAVKC 143
Cdd:cd10562   84 TGALYKTEnGAVVVDEDKCIGCGYCVAACPFDVPRYDETTN----------------------------------KITKC 129

                        170       180
                 ....*....|....*....|....*
gi 516289465 144 DLCsFD--EQG--PACVRTCPTRAL 164
Cdd:cd10562  130 TLC-FDriENGmqPACVKTCPTGAL 153
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 12-186 1.43e-19

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 81.67  E-value: 1.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  12 CIGCRTCEAACSETHRlHGLQSMPRLR-VMRNE-KESAPQLCHHCEDAPCAGVCPVNAITRV-DGAVQL-NESLCVSCKL 87
Cdd:cd16369   11 CIGCRACVAACRECGT-HRGKSMIHVDyIDRGEsTQTAPTVCMHCEDPTCAEVCPADAIKVTeDGVVQSaLKPRCIGCSN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  88 CGIACPFGAIEFSGSRPLHIpanantpkappappaparvstlldwvpgiravavKCDLC---SFDEQGPACVRTCPTRAL 164
Cdd:cd16369   90 CVNACPFGVPKYDEERNLMM----------------------------------KCDMCydrTSVGKAPMCASVCPSGAL 135

                        170       180
                 ....*....|....*....|..
gi 516289465 165 VLVNIRDIArtSKRKRELTINT 186
Cdd:cd16369  136 FYGTREEIQ--ALRPGSTPVNT 155
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 8-182 1.34e-18

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 80.12  E-value: 1.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   8 DSTVCIGCRTCEAACSETHRL---------HGLQSMPRLR---------VMRNEKESAPQ------------LCHHCEDA 57
Cdd:cd10560    5 DTSICIGCKACEVACKQWNQLpadgydfsgMSYDNTGDLSastwrhvkfIERPTEDGPANeggdlqwlfmsdVCKHCTDA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  58 PCAGVCPVNAITRVD-GAVQLNESLCVSCKLCGIACPFGAIEFsgsrplhipaNANTPKappappaparvstlldwvpgi 136
Cdd:cd10560   85 GCLEACPTGAIFRTEfGTVYIQPDICNGCGYCVAACPFGVIDR----------NEETGR--------------------- 133

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 516289465 137 ravAVKCDLCsFDEQG----PACVRTCPTRALVLVNIRD-IARTSKRKREL 182
Cdd:cd10560  134 ---AHKCTLC-YDRLKdglePACAKACPTGSIQFGPLEElRERARARVEQL 180
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
8-165 9.07e-16

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 73.94  E-value: 9.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   8 DSTVCIGCRTCEAACSETHRLHGLQSMPRL---------------RVMRN-EKESAPQL----------CHHCEDAPCAG 61
Cdd:PRK10882  43 DSTLCVGCQACVTKCQEINFPERNPQGEQTwdnpdklspytnniiKVWKSgTGVNKDQEengyayikkqCMHCVDPNCVS 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  62 VCPVNAITR--VDGAVQLNESLCVSCKLCGIACPFGAIEFSGSRPLhipanantpkappappaparvstlldwvPGIrav 139
Cdd:PRK10882 123 VCPVSALTKdpKTGIVHYDKDVCTGCRYCMVACPFNVPKYDYNNPF----------------------------GAI--- 171

                        170       180       190
                 ....*....|....*....|....*....|...
gi 516289465 140 aVKCDLCS-------FDEQGPACVRTCPTRALV 165
Cdd:PRK10882 172 -HKCELCNqkgverlDKGGLPGCVEVCPTGAVI 203
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 8-167 7.87e-15

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 68.54  E-value: 7.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   8 DSTVCIGCRTCEAACSETHRL-HGLQSMPRLRVMRNEKESAPQL------CHHCEDAPCAGVCPVNAITR--VDGAVQLN 78
Cdd:cd10553    8 DSKRCIGCLACEVHCKVKNNLpVGPRLCRIFAVGPKMVGGKPRLkfvymsCFHCENPWCVKACPTGAMQKreKDGIVYVD 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  79 ESLCVSCKLCGIACPFGAIEFSGSRplhipanantpkappappaparvstlldwvpgirAVAVKCDLCSFD-EQG--PAC 155
Cdd:cd10553   88 QELCIGCKACIEACPWGIPQWNPAT----------------------------------GKVVKCDYCMDRiDQGlkPAC 133

                        170
                 ....*....|..
gi 516289465 156 VRTCPTRALVLV 167
Cdd:cd10553  134 VTGCTTHALSFV 145
TH_beta_N cd10552
N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This ...
 4-181 2.98e-14

N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This family includes the beta subunit of pyrogallol-phloroglucinol transhydroxylase (TH), a cytoplasmic molybdenum (Mo) enzyme from anaerobic microorganisms like Pelobacter acidigallici and Desulfitobacterium hafniense which catalyzes the conversion of pyrogallol to phloroglucinol, an important building block of plant polymers. TH belongs to the DMSO reductase (DMSOR) family; it is a heterodimer consisting of a large alpha catalytic subunit and a small beta FeS subunit. The beta subunit has two domains with the N-terminal domain containing three [4Fe-4S] centers and a seven-stranded, mainly antiparallel beta-barrel domain. In the anaerobic bacterium Pelobacter acidigallici, gallic acid, pyrogallol, phloroglucinol, or phloroglucinol carboxylic acid are fermented to three molecules of acetate (plus CO2), and TH is the key enzyme in the fermentation pathway, which converts pyrogallol to phloroglucinol in the absence of O2.


Pssm-ID: 319874 [Multi-domain]  Cd Length: 186  Bit Score: 67.74  E-value: 2.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   4 FVIaDSTVCIGCRTCEAACSETHrlHG------LQSMPR-----LRVMRNEKESA--------PQLCHHCEDAPCAGVCP 64
Cdd:cd10552    1 LVI-DVAKCNGCYNCFLACKDEH--VGndwpgyAAPQPRhghfwMRILRRERGQYpkvdvaylPVPCNHCDNAPCIKAAK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  65 VNAIT-RVDGAVQLNESLCVSCKLCGIACPFGAIEFsgSRPLHIPAnantpkappappaparvstlldwvpgiravavKC 143
Cdd:cd10552   78 DGAVYkRDDGIVIIDPEKAKGQKQLVDACPYGAIYW--NEELQVPQ--------------------------------KC 123

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 516289465 144 DLCSF----DEQGPACVRTCPTRALVLVNIRDIARTSKRKRE 181
Cdd:cd10552  124 TFCAHllddGWKEPRCVQACPTGALRFGKLEDEEMAAKAAEE 165
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 3-104 6.28e-14

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 65.43  E-value: 6.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   3 RFVIADSTVCIGCRTCEAACSETHRLHGLQSMPRLRVMRNEKESAPQLCHHCedAPCAGVCPVNAITR-VDGAVQLNESL 81
Cdd:cd16372    1 KLLVTDPEKCIGCLQCEEACSKTFFKEEDREKSCIRITETEGGYAINVCNQC--GECIDVCPTGAITRdANGVVMINKKL 78

                         90       100
                 ....*....|....*....|...
gi 516289465  82 CVSCKLCGIACPFGAIEFSGSRP 104
Cdd:cd16372   79 CVGCLMCVGFCPEGAMFKHEDYP 101
FDH-beta TIGR01582
formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit ...
 8-165 4.43e-13

formate dehydrogenase, beta subunit, Fe-S containing; This model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well. [Energy metabolism, Anaerobic, Energy metabolism, Electron transport]


Pssm-ID: 273705 [Multi-domain]  Cd Length: 283  Bit Score: 66.09  E-value: 4.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465    8 DSTVCIGCRTCEAACSETHRLH---------GLQSMPRL-----RVMR-NEKESAPQL--------CHHCEDAPCAGVCP 64
Cdd:TIGR01582  27 DVSSCIGCKACQAACQEWNDTTppilsrkvgGYQNPPDLlpetfTLMRfKEGEESDGLewlirkdgCMHCREPGCLKACP 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   65 VNA--ITRVDGAVQLNESLCVSCKLCGIACPFGAiefsgsrPLHIPANANtpkappappaparvstlldwvpgiravAVK 142
Cdd:TIGR01582 107 APGaiIQYQNGIVDFDHSKCIGCGYCIVGCPFNI-------PRYDKVDNR---------------------------PYK 152

                         170       180
                  ....*....|....*....|....*..
gi 516289465  143 CDLCSfDE----QGPACVRTCPTRALV 165
Cdd:TIGR01582 153 CTLCI-DRvsvgQEPACVKTCPTNAIS 178
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 3-99 3.72e-12

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 60.75  E-value: 3.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   3 RFVIADSTVCIGCRTCEAACSET-HRLHGLQSmPRLRVMRN---EKESAPQLCHHCEDAPCAGVCPVNAIT-RVDGAVQL 77
Cdd:cd16370    2 RLRVKDMERCIGCYSCMLACSRRvHKSASLSK-SAIRVRTRgglEGGFTVVVCRACEDPPCAEACPTGALEpRKGGGVVL 80

                         90       100
                 ....*....|....*....|..
gi 516289465  78 NESLCVSCKLCGIACPFGAIEF 99
Cdd:cd16370   81 DKEKCIGCGNCVKACIVGAIFW 102
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 48-166 1.52e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 58.41  E-value: 1.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   48 PQLCHHCEDAPCAGVCPVNAITR--VDGAVQLNESLCVSCKLCGIACPFGAIEFsgsrplhipanantpkappappapar 125
Cdd:pfam13247   7 PEQCRHCLNPPCKASCPVGAIYKdeETGAVLLDEKTCRGWRECVSACPYNIPRY-------------------------- 60

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 516289465  126 vstllDWVPGiraVAVKCDLC-SFDEQG--PACVRTCPTRALVL 166
Cdd:pfam13247  61 -----NDETG---KAEKCDMCyDRVEAGllPACVQTCPTGAMNF 96
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
12-96 1.75e-11

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 61.04  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  12 CIGCRTCEAACSETHRLHGLQ---SMPRLRVMRNEKESA-----PQLCHHCEDAPCAGVCPVNA-ITRVDGAVQLNESLC 82
Cdd:PRK14993  53 CIGCQSCTVSCTIENQTPQGAfrtTVNQYQVQREGSQEVtnvllPRLCNHCDNPPCVPVCPVQAtFQREDGIVVVDNKRC 132

                         90
                 ....*....|....
gi 516289465  83 VSCKLCGIACPFGA 96
Cdd:PRK14993 133 VGCAYCVQACPYDA 146
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
11-97 1.97e-11

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 61.97  E-value: 1.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  11 VCIGCRTCEAACSETHRLHGLQSMPRLRVMRNEKESapqlCHHCEdaPCAGVCPVNAITRVDGAVQLNESLCVSCKLCGI 90
Cdd:COG4624   57 CCCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKEK----CKNCY--PCVRACPVKAIKVDDGKAEIDEEKCISCGQCVA 130


                 ....*..
gi 516289465  91 ACPFGAI 97
Cdd:COG4624  131 VCPFGAI 137
PRK09898 PRK09898
ferredoxin-like protein;
5-95 3.47e-09

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 54.46  E-value: 3.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   5 VIADSTVCIGCRTCEAACSETH--RLHGLQSmpRLRVMRN----------------EKESAPQLCHHCEDAPCAGVCPVN 66
Cdd:PRK09898  61 LVTQRARCTGCHRCEISCTNFNdgSVGTFFS--RIKIHRNyffgdngvgsggglygDLNYTADTCRQCKEPQCMNVCPIG 138

                         90       100       110
                 ....*....|....*....|....*....|.
gi 516289465  67 AIT--RVDGAVQLNESLCVSCKLCGIACPFG 95
Cdd:PRK09898 139 AITwqQKEGCITVDHKRCIGCSACTTACPWM 169
DMSOR_beta_like cd16368
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 48-163 1.05e-08

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319890 [Multi-domain]  Cd Length: 200  Bit Score: 52.81  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  48 PQLCHHCEDAPCAGVCPVNAIT-RVDGAVQLNESLCVSCKLCGIACPFgaiefsgsrplHIPAnantpkappappAPARV 126
Cdd:cd16368   88 PRRCMHCDNPPCAKLCPFGAARkTPEGAVYIDDDLCFGGAKCRDVCPW-----------HIPQ------------RQAGV 144

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 516289465 127 STLLDWVPGI--RAVAVKCDLCS---FDEQGPACVRTCPTRA 163
Cdd:cd16368  145 GIYLHLAPEYagGGVMYKCDLCKdllAQGKPPACIEACPKGA 186
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
48-99 1.56e-08

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 49.73  E-value: 1.56e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 516289465  48 PQLCHHCEDapCAGVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAIEF 99
Cdd:COG2768   10 EEKCIGCGA--CVKVCPVGAISIEDGKAVIDPEKCIGCGACIEVCPVGAIKI 59
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 48-99 3.13e-08

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 48.57  E-value: 3.13e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 516289465  48 PQLCHHCEDapCAGVCPVNAITRVDG-AVQLNESLCVSCKLCGIACPFGAIEF 99
Cdd:COG1149   10 EEKCIGCGL--CVEVCPEGAIKLDDGgAPVVDPDLCTGCGACVGVCPTGAITL 60
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 48-104 3.84e-08

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 48.50  E-value: 3.84e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 516289465  48 PQLCHHCEDapCAGVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAIEFSGSRP 104
Cdd:COG4231   21 EDKCTGCGA--CVKVCPADAIEEGDGKAVIDPDLCIGCGSCVQVCPVDAIKLEKRVP 75
EBDH_beta cd10555
beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene ...
 48-163 5.23e-08

beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene dehydrogenase (EBDH, EC 1.17.99.2), a member of the DMSO reductase family. EBDH oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. It is a heterotrimer, with the alpha subunit containing the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, the beta subunit containing four iron-sulfur clusters (the electron transfer subunit) and the gamma subunit containing a methionine and a lysine as axial heme ligands. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration.


Pssm-ID: 319877 [Multi-domain]  Cd Length: 316  Bit Score: 51.92  E-value: 5.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  48 PQLCHHCEDAPCAGVCPVNAITR--VDGAVQLNESLCVSCKLCGIACPFGAIEFsgsrplhipanaNTpkappappapar 125
Cdd:cd10555  130 PRICNHCTNPACLAACPRKAIYKreEDGIVLVDQDRCRGYRYCVEACPYKKIYF------------NP------------ 185

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 516289465 126 vstlldwvpgIRAVAVKCDLCsFD--EQG--PACVRTCPTRA 163
Cdd:cd10555  186 ----------VEQKSEKCIFC-YPriEKGvaPACARQCVGRI 216
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 1-100 5.71e-08

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 49.70  E-value: 5.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   1 MNRFVIADSTVCIGCRTCEAACSeTHRLHGLQSMPRLRVMRNEKESAPQLCHHCEDapCAGVCPVNAITRVDGA-VQLNE 79
Cdd:cd10549   31 IARGPEIDEDKCVFCGACVEVCP-TGAIELTPEGKEYVPKEKEAEIDEEKCIGCGL--CVKVCPVDAITLEDELeIVIDK 107

                         90       100
                 ....*....|....*....|.
gi 516289465  80 SLCVSCKLCGIACPFGAIEFS 100
Cdd:cd10549  108 EKCIGCGICAEVCPVNAIKLV 128
W-FDH cd10559
tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit ...
 8-182 4.78e-07

tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit of Tungsten-containing formate dehydrogenase (W-FDH), a member of the DMSO reductase family. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319881 [Multi-domain]  Cd Length: 200  Bit Score: 48.20  E-value: 4.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   8 DSTVCIGCRTCEAACSETHRLHGLQSM--------PRL------RVMRNEKESA---------PQLCHHCEDAPCAGVCP 64
Cdd:cd10559    5 DTTRCTACRGCQVACKQWNQLPAEQTKntgshqnpPDLsantykLVRFNEVRNEngkpdwlffPDQCRHCVTPPCKDAAD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  65 V--NAITRVD--GAVQLNESLCVSC-KLCGIACPFgaiefsgsrplHIP-ANANTPKAppappaparvstlldwvpgira 138
Cdd:cd10559   85 MvpGAVIQDEatGAVVFTEKTAELDfDDVLSACPY-----------NIPrKNEATGRI---------------------- 131

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 516289465 139 vaVKCDLCsFDE----QGPACVRTCPTRALVLVNIRDI-ARTSKRKREL 182
Cdd:cd10559  132 --VKCDMC-IDRvsngLQPACVKACPTGAMNFGDRDEMlAMASKRLEEL 177
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 59-98 7.07e-07

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 45.04  E-value: 7.07e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 516289465  59 CAGVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAIE 98
Cdd:COG2221   23 CVAVCPTGAISLDDGKLVIDEEKCIGCGACIRVCPTGAIK 62
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
48-101 1.99e-06

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 47.55  E-value: 1.99e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 516289465  48 PQLCHHCEdaPCAGVCPVNAITRVDGAV-QLNESLCVSCKLCGIACPFGAIEFSG 101
Cdd:COG1148  495 PEKCTGCG--RCVEVCPYGAISIDEKGVaEVNPALCKGCGTCAAACPSGAISLKG 547
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 48-108 2.32e-06

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 45.08  E-value: 2.32e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516289465  48 PQLCHHCedAPCAGVCPVNAITRVDG-----AVQLNESLCVSCKLCGIACPFGAIEFSGSRPLHIP 108
Cdd:cd10549    5 PEKCIGC--GICVKACPTDAIELGPNgaiarGPEIDEDKCVFCGACVEVCPTGAIELTPEGKEYVP 68
NapF COG1145
Ferredoxin [Energy production and conversion];
48-99 4.06e-06

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 45.87  E-value: 4.06e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 516289465  48 PQLCHHCEdaPCAGVCPVNAITRVDGAVQL--NESLCVSCKLCGIACPFGAIEF 99
Cdd:COG1145  181 AEKCIGCG--LCVKVCPTGAIRLKDGKPQIvvDPDKCIGCGACVKVCPVGAISL 232
flavo_MJ0208 TIGR02700
archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of ...
 51-97 4.30e-06

archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of archaealflavoprotein. The other, described by TIGR02699 and typified by the partially characterized AF1518 of Archaeoglobus fulgidus, is a homodimeric FMN-containing flavoprotein that accepts electrons from ferredoxin and can transfer them to various oxidoreductases. The function of this protein family is unknown. [Unknown function, General]


Pssm-ID: 131747 [Multi-domain]  Cd Length: 234  Bit Score: 45.63  E-value: 4.30e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 516289465   51 CHHCEDapCAGVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAI 97
Cdd:TIGR02700 150 CKGCGI--CVDACPRSAIDMVDGKAFIRLLKCVGCGKCKEACPYNAI 194
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 48-100 8.94e-06

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 42.04  E-value: 8.94e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 516289465  48 PQLCHHCEDapCAGVCPVNAITRVDG----AVQLNESLCVSCKLCGIACPFGAIEFS 100
Cdd:COG1143    1 EDKCIGCGL--CVRVCPVDAITIEDGepgkVYVIDPDKCIGCGLCVEVCPTGAISMT 55
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 48-98 1.17e-05

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 45.16  E-value: 1.17e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516289465  48 PQLCHHcedaPCAGVCPVN-----AIT--RVDGAVQLNESLCVSCKLCGIACPFGAIE 98
Cdd:COG1245   14 PKKCNY----ECIKYCPVNrtgkeAIEidEDDGKPVISEELCIGCGICVKKCPFDAIS 67
NarH_like cd16365
beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several ...
 12-101 1.38e-05

beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several DMSO reductase superfamily, including nitrate reductase A, ethylbenzene dehydrogenase and selenate reductase. DMSO Reductase (DMSOR) family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. . The beta subunits of DMSOR contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Nitrate reductase A contains three subunits (the catalytic subunit NarG, the catalytic subunit NarH with four [Fe-S] clusters, and integral membrane subunit NarI) and often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Ethylbenzene dehydrogenase oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. Selenate reductase catalyzes reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor.


Pssm-ID: 319887 [Multi-domain]  Cd Length: 201  Bit Score: 44.11  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465  12 CIGCRTCEAAC---------SETHRLHGLQSMPRLRVMRNEKESA-------------PQLCHHCEDAPCAGVCPVNAIT 69
Cdd:cd16365   12 CIGCQTCTVACknawtyrkgQEYMWWNNVETKPGGGYPQDWEVKTidnggntrfffylQRLCNHCTNPACLAACPRGAIY 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 516289465  70 RV--DGAVQLNESLCVSCKLCGIACPFGAIEFSG 101
Cdd:cd16365   92 KReeDGIVLIDQKRCRGYRKCVEQCPYKKIYFNG 125
SER_beta cd10556
Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate ...
 48-94 1.66e-05

Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate reductase (SER), a member of the DMSO reductase family. SER catalyzes the reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor. The enzyme comprises three subunits SerABC, forming a heterotrimer, with the catalytic component (alpha-subunit), iron-sulfur protein (beta-subunit) and monomeric b-type heme-containing gamma subunit. Beta subunit contains coordinating one [3Fe-4S] cluster and three [4Fe-4S] clusters and functions as electron carrier.


Pssm-ID: 319878 [Multi-domain]  Cd Length: 287  Bit Score: 44.37  E-value: 1.66e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 516289465  48 PQLCHHCEDAPCAGVCPVNAITR--VDGAVQLNESLCVSCKLCGIACPF 94
Cdd:cd10556  138 PRICNHCTYPACLAACPRKAIYKreEDGIVLIDQERCRGYRECVEACPY 186
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 48-106 2.65e-05

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 40.85  E-value: 2.65e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516289465  48 PQLCHHCEDapCAGVCPVNAITRVDG---AVQLNESLCVSCKLCGIACPFGAIEFSGSRPLH 106
Cdd:COG1146    7 TDKCIGCGA--CVEVCPVDVLELDEEgkkALVINPEECIGCGACELVCPVGAITVEDDEPEE 66
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 59-99 1.16e-04

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 41.60  E-value: 1.16e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 516289465  59 CAGVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAIEF 99
Cdd:cd03110   72 CERVCKFGAILEFFQKLIVDESLCEGCGACVIICPRGAIYL 112
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 51-98 1.27e-04

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 39.26  E-value: 1.27e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 516289465  51 CHHCedAPCAGVCPVNAITRVDGA-VQLNESLCVSCKLCGIACPFGAIE 98
Cdd:COG1144   32 CIGC--GLCWIVCPDGAIRVDDGKyYGIDYDYCKGCGICAEVCPVKAIE 78
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
59-99 1.32e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 41.46  E-value: 1.32e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 516289465  59 CAGVCPVNAITRVDGAVQLNESLCVSCKLCGIACPFGAIEF 99
Cdd:PRK07118 147 CVAACPFDAIHIENGLPVVDEDKCTGCGACVKACPRNVIEL 187
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
48-98 1.43e-04

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 41.72  E-value: 1.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516289465  48 PQLCHHcedaPCAGVCPVN-----AIT--RVDGAVQLNESLCVSCKLCGIACPFGAIE 98
Cdd:PRK13409  14 PKKCNY----ECIKYCPVVrtgeeTIEidEDDGKPVISEELCIGCGICVKKCPFDAIS 67
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
2-98 3.10e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 40.30  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289465   2 NRFVIADSTVCIGCRTCEAACSeTHRLHGLQSMPRLRVMRNEKESAPQLCHHCEDA-----PCAGVCPVNAITRVDGAVQ 76
Cdd:PRK07118 160 NGLPVVDEDKCTGCGACVKACP-RNVIELIPKSARVFVACNSKDKGKAVKKVCEVGcigcgKCVKACPAGAITMENNLAV 238

                         90       100
                 ....*....|....*....|..
gi 516289465  77 LNESLCVSCKLCGIACPFGAIE 98
Cdd:PRK07118 239 IDQEKCTSCGKCVEKCPTKAIR 260
NarH_beta-like cd10557
beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes ...
 48-99 3.22e-04

beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes nitrate reductase A, a member of the DMSO reductase family. The respiratory nitrate reductase complex (NarGHI) from E. coli is a heterotrimer, with the catalytic subunit (NarG) with a molybdo-bis (molybdopterin guanine dinucleotide) cofactor and an [Fe-S] cluster, the electron transfer subunit (NarH) with four [Fe-S] clusters, and the integral membrane subunit (NarI) with two b-type hemes. Nitrate reductase A often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Electron transfer from formate to nitrate is coupled to proton translocation across the cytoplasmic membrane generating proton motive force by a redox loop mechanism. Demethylmenaquinol (DMKH2) has been shown to be a good substrate for NarGHI in nitrate respiration in E. coli.


Pssm-ID: 319879 [Multi-domain]  Cd Length: 363  Bit Score: 40.42  E-value: 3.22e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 516289465  48 PQLCHHCEDAPCAGVCPVNAITR--VDGAVQLNESLCVSCKLCGIACPFGAIEF 99
Cdd:cd10557  176 PRICNHCLNPACVAACPSGAIYKreEDGIVLIDQDRCRGWRMCVSACPYKKVYY 229
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 50-98 3.89e-04

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 40.63  E-value: 3.89e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 516289465  50 LCHHCEDapCAGVCPVNAITRVD--GAVQLNESLCVSCKLCGIACPFGAIE 98
Cdd:PRK12771 511 NCFECDN--CYGACPQDAIIKLGpgRRYHFDYDKCTGCHICADVCPCGAIE 559
PRK13795 PRK13795
hypothetical protein; Provisional
 59-93 1.30e-03

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 38.82  E-value: 1.30e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 516289465  59 CAGVCPVNAITRVDG--AVQLNESLCVSCKLCGIACP 93
Cdd:PRK13795 589 CVGACPTGAIRIEEGkrKISVDEEKCIHCGKCTEVCP 625
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 51-108 2.99e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 36.85  E-value: 2.99e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516289465  51 CHHCEDApCAGVCPVNAITRVD--------GAVQLNESLCVS------CKLCGIACPFGAIEFSGSRPLHIP 108
Cdd:cd16373   55 CDLCCDA-CVEVCPTGALRPLDleeqkvkmGVAVIDKDRCLAwqggtdCGVCVEACPTEAIAIVLEDDVLRP 125
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 51-96 3.01e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 34.81  E-value: 3.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 516289465   51 CHHCEDapCAGVCPVNAITRVD-------GAVQLNESLCVSCKLCGIACPFGA 96
Cdd:pfam12838   1 CIGCGA--CVAACPVGAITLDEvgekkgtKTVVIDPERCVGCGACVAVCPTGA 51
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
76-99 5.43e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 37.15  E-value: 5.43e-03
                         10        20
                 ....*....|....*....|....
gi 516289465  76 QLNESLCVSCKLCGIACPFGAIEF 99
Cdd:COG1148  492 EVDPEKCTGCGRCVEVCPYGAISI 515
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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