|
Name |
Accession |
Description |
Interval |
E-value |
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-468 |
4.60e-101 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 311.45 E-value: 4.60e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 1 MKTRKIGLANYFAYGSGDFLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDNFGTtwlgkR 80
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRT-----R 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 81 FGRRKFFILLG-IPCVFSYSLMWV-----GDMSFWYYLLTYLIFDIVYTMILVPYETLVPEMTDDFKQKTKFSGARISMA 154
Cdd:COG2211 77 WGRRRPWILIGaIPLALSFVLLFTapdlsPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 155 QMSAILASFLPGILLTHFGKDNAISFFYASLVFSVLCALMLTFVWFFTWERPReewseaalraeEEKKKLTLGQSlnrlf 234
Cdd:COG2211 157 GLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPV-----------PEEEKVSLKES----- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 235 veLSSTLRIKIFRQHLGMYLGGYIAQDVFNAVFTYYVVFVLMQEASMASNLLGTMAIFQFLAVIGMIPLCIRFGPAPSYR 314
Cdd:COG2211 221 --LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFI 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 315 MVVVLFGLAslsYAVLYYAGLSDVYaLLLLISAVAGLGRGGINYVPWNTYTYIADVDEVITGQRREGIFAGIMTLTRKAS 394
Cdd:COG2211 299 IGLLLAALG---LLLLFFLGPGNLW-LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLG 374
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516289931 395 QAGAVMLVGIVMQMSGFVSGQkVQPAEVSHTILMILSVGTILVLFCGFLVSLRFKLNLQTHSTLREETAKMRES 468
Cdd:COG2211 375 QALAGALAGLLLALFGYVAGA-AQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
11-451 |
8.42e-101 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 310.31 E-value: 8.42e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 11 YFAYGSGDFLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDNFGTTWlgkrFGRRKFFILL 90
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRW----GRFRPWLLWG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 91 GIPCVFSYSLMWVGDMS-----FWYYLLTYLIFDIVYTMILVPYETLVPEMTDDFKQKTKFSGARISMAQMSAILASFLP 165
Cdd:cd17332 77 AIPLALLFVLLFTTPDGsgtgkLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 166 GILLTHFGKDNA-ISFFYASLVFSVLCALMLTFVWFFTWERPREEwseaalraEEEKKKLTLGQSLNRLFvelsstlRIK 244
Cdd:cd17332 157 PPLVAYFGGGNAsRGYFLTALIIGIIGIILLLICFFGTRERVVPP--------EEEKSKLPLLKSLKALL-------KNR 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 245 IFRQHLGMYLGGYIAQDVFNAVFTYYVVFVLMqEASMASNLLGTMAIFQFLAVIGMIPLCIRFGPAPSYRMVVVLFGLAS 324
Cdd:cd17332 222 PFLILLLAYLLYFLAFNIVNTVLVYYFKYVLG-GRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 325 LSYAVLYYaglsDVYALLLLISAVAGLGRGGINYVPWNTYTYIADVDEVITGQRREGIFAGIMTLTRKASQAGAVMLVGI 404
Cdd:cd17332 301 LLLFFLPP----GNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGL 376
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 516289931 405 VMQMSGFVSGQKVQPAEVSHTILMILSVGTILVLFCGFLVSLRFKLN 451
Cdd:cd17332 377 ILSLAGYVANAAAQSASALNGIRLLIAVLPAVLLLLALILMSFYPLD 423
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
13-451 |
2.28e-48 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 172.88 E-value: 2.28e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 13 AYGSGDFLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDNFGTTWlgkrfGRRKFFILLG- 91
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRW-----GRRRPWLLLSa 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 92 IPCVFSYSLMW-----VGDMSFWYYLLTYLIFDIVYTMILVPYETLVPEMTDDFKQKTKFSGARISMAQMSAILASFLPG 166
Cdd:pfam13347 76 IILAVSFILLFtppelGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 167 ILLTHFG--KDNAISFFYASLVFSVLCALMLTFVWFFTWERPreewSEAALRAEEEKKKLTLGQSLNRLFvelsstlRIK 244
Cdd:pfam13347 156 PLVLILGgtGLERKGYRIFALIGAVLMLLGVIITAAGTKERV----SMRSKEDTGQKEAGSLLDMLKEVF-------RNR 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 245 IFRQHLGMYLGGYIAQDVFNAVFTYYVVFVLmQEASMASNLLGTMAIFQFLAVIGMIPLCIRFGpapSYRMVVVLFGLAS 324
Cdd:pfam13347 225 AFLILLASFLLAALAMGVLNGLLLYYFRYVL-GNGFAASAFPLVFTIGALLGIPLWPPLAKRIG---KKNTYILGALITI 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 325 LSYAVLYYAGLSDvYALLLLISAVAGLGRGGINYVPWNTYTYIADVDEVITGQRREGIFAGIMTLTRKASQAGAVMLVGI 404
Cdd:pfam13347 301 AGFALALLLGPNN-TLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGL 379
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 516289931 405 VMQMSGFVSGQKVQPAEVSHTILMILSVGTILVLFCGFLVSLRFKLN 451
Cdd:pfam13347 380 LLSAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLD 426
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
12-461 |
6.45e-35 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 136.23 E-value: 6.45e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 12 FAYGSGDFLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDNFGTtwlgkRFGRRKFFILLG 91
Cdd:TIGR00792 2 LSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRT-----RWGKFRPWLLIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 92 --IPCVFSYSLMWVGDMSFWYYL----LTYLIFDIVYTMILVPYETLVPEMTDDFKQKTKFSGARISMAQMSAILASFLP 165
Cdd:TIGR00792 77 aiPFSIVLVLLFTTPDFSGTGKLvyayITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 166 GILLTHFGKDN-AISFFYASLVFSVLCALMLTFVWFFTWERPREEwseaalrAEEEKKKLTLGQSLNRLFVelSSTLRIK 244
Cdd:TIGR00792 157 LPLVSYFGGGDdKFGWFMFALVLALIGVVSLIICFFGTKERYSEI-------PKNIEKKLSLKQIFKALFK--NDQLLIL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 245 IFrqhlgMYLGGYIAQDVFNAVFTYYVVFVLMQEASMAsnLLGTMAIFQFLAVIGMIPLCI-RFGpapsyRMVVVLFG-- 321
Cdd:TIGR00792 228 CL-----AYLFYNLAFNIKNGVQVYYFTYVLGDPELFS--YMGSIAIVAGLIGVLLFPRLVkKFG-----RKILFAGGil 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 322 LASLSYAVLYYAGLSDVYALLLLIsaVAGLGRGGINYVPWNTYTYIADVDEVITGQRREGIFAGIMTLTRKASQAGAVML 401
Cdd:TIGR00792 296 LMVLGYLIFFFAGSNLPLILVLII--LAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFF 373
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 402 VGIVMQMSGFVSGQKVQPAEVSHTILMILSVGTILVLFCGFLVSLRFKLNLQTHSTLREE 461
Cdd:TIGR00792 374 VGLILGIIGYVANAAQSPITLNGIKILMFAVPALFLLLAAIIIGRFYKLTEKKHAEIVEE 433
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
1-464 |
1.37e-23 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 103.27 E-value: 1.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 1 MKTRKIGLANYFAYGSGDFLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDNFGTtwlgkR 80
Cdd:PRK09669 1 MNTSQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRT-----R 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 81 FGRRKFFIL-----LGIPCVFSYslmWVGDMSFW----YYLLTYLIFDIVYTMILVPYETLVPEMTDDFKQKTKFSGARI 151
Cdd:PRK09669 76 HGQFRPYLLwfaipFGVVCLLTF---YTPDFGATgkiiYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRF 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 152 SMAQMSAILASFLPGILLTHFGKDNA-ISFFYASLVFSVLCALMLTFVWFFTWER--PREEWSEAALRaeeeKKKLTLGQ 228
Cdd:PRK09669 153 ALSFIGGLIVSVIALPLVDILGKGDEqKGYFYAMMVMGLLGVVLFFCCFFMTKERytPEVDNSSSVWK----DLKLLLGN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 229 SLNRLFVELSSTLRIKIfrqhlgmylggyiaqdVFNAVFTYYVVFVLMQEASMASNLLGTMAIFQFLAVIGMIPLCIRFG 308
Cdd:PRK09669 229 SQWRIMFIFNVVLLTAV----------------VTRGGATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKFD 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 309 PAPSYRMVVVLFGLASLSYAVLYYAGLSDVYALLLLISAVAGLgrggINYVPWNTYTYIADVDEVITGQRREGIFAGIMT 388
Cdd:PRK09669 293 RVRAFKWTIVAFVILSALIFFIPPSNVWLIFALNILFNFIQNL----TTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNL 368
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516289931 389 LTRKASQAGAVMLVGIVMQMSGFVSGQKVQPAEVSHTILMILSVGTILVLFCGFLVSLRFKLNLQTHSTLREETAK 464
Cdd:PRK09669 369 FAIKLGLAIGGAVVGWILAWVDYVGGAAVQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDARVEAIAQELVK 444
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
4-469 |
1.19e-21 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 97.55 E-value: 1.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 4 RKIGLANYFAYGSGDFLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDNFGTtwlgkRFGR 83
Cdd:PRK09848 3 QQLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNT-----RWGK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 84 RKFFILLG-IP------CVFSYSLMWVGDMSFWYYLLTYLIFDIVYTMILVPYETLVPEMTDDFKQKTKFSGARISMAQM 156
Cdd:PRK09848 78 FRPFLLFGtAPlmifsvLVFWVPTDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 157 SAILASFLPGILLTHFGKDNAISFFyasLVFSVLCALMLTFVWFFTWERPREewseaalRAEEEKKKLTLGQSLNRLFVE 236
Cdd:PRK09848 158 TFVCLAFLIGPSIKNSSPEEMVSVY---HFWTIVLAIAGMVLYFICFKSTRE-------NVVRIVAQPSLKISLQTLKRN 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 237 LSstlrikIFRQHLG--MYLGGYIAqdvFNAVFTYYVVFVLMQEASMASNLLGTMAIFQFLAVIGMIPLCIRFGPAPSYr 314
Cdd:PRK09848 228 RP------LFMLCIGalCVLISTFA---VSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTF- 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 315 mvvvLFG--LASLSYAVLYYAGLSDVYALLLLIsAVAGLGRGGINYVPWNTYTYIADVDEVITGQRREGIFAGIMTLTRK 392
Cdd:PRK09848 298 ----LIGalLGTCGYLLFFWVSVWSLPVALVAL-AIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRK 372
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516289931 393 ASQAGAVMLVGIVMQMSGFVSGQkVQPAEVSHTILMILSVGTILVLFCGFLVSLRFKLNLQTHSTLREETAKMRESG 469
Cdd:PRK09848 373 CGQAIGGSIPAFILGLSGYIANQ-VQTPEVIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKKVQ 448
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
4-451 |
3.04e-21 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 96.70 E-value: 3.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 4 RKIGLANYFAYGSGDFLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDNFGTtwlgkRFGR 83
Cdd:PRK10429 1 MSISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRS-----RWGK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 84 RKFFILLG--IPCVFSYSL----MWVGDMSFWYYLLTYLIFDIVYTMILVPYETLVPEMTDDFKQKTKFSgariSMAQMS 157
Cdd:PRK10429 76 FKPWILIGtlANSVVLFLLfsahLFEGTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLV----PYPRFF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 158 AILASFLPGILLTHF-----GKDNAISFFYASLVFSVlCALMLTFVwffTWERPREEWSEAALRAEEEkKKLTLGQSLNR 232
Cdd:PRK10429 152 ASLAGFVTAGFTLPFvnyvgGGDRGFGFQMFTLVLIA-FFIVSTII---TLRNVHEVYSSDNQVSAEG-SHLTLKDIVAL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 233 LFV--ELSSTlrikifrqhLGMYLGGYIAQDVFNAVFTYYVVFVlmqeasmasnlLGTMAIFQ-FLAVIG---MIPLCI- 305
Cdd:PRK10429 227 IYKndQLSCL---------LGMALAYNIASNIINGFAIYYFTYV-----------IGDADLFPyYLSYAGaanLVTLILf 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 306 -RFGPAPSYRmvvVLFGLAS----LSYAVLYYAGLSDVYALLLLISAVAGLGRGGINYVPWNTYTYIADVD--EVITGQR 378
Cdd:PRK10429 287 pRLVKSLSRR---ILWAGASifpvLSCGVLLLMGLAAPHNALLIVIAGILLNIGTALFWVLQVIMVADTVDygEYKLGIR 363
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516289931 379 REGIFAGIMTLTRKASQAGAVMLVGIVMQMSGFVSGQkVQPAEVSHTI-LMILSVGTILVLFCGFLVSLRFKLN 451
Cdd:PRK10429 364 CESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYVPNV-EQSAQTLLGMqFIMIGLPTLFFMITLVLYFRYYRLN 436
|
|
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
1-218 |
5.44e-15 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 77.28 E-value: 5.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 1 MKTRKIGLANYFAYGSGDFLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDNFGTTWLGKR 80
Cdd:PRK11462 1 MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 81 ----FGRRKFfillGIPCVFSYS---LMWVGDMSfwYYLLTYLIFDIVYTMILVPYETLVPEMTDDFKQKTKFSGARISM 153
Cdd:PRK11462 81 pwvlFGALPF----GIVCVLAYStpdLSMNGKMI--YAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVL 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516289931 154 AQMSAILASFLPGILLTHFGKDN-AISFFYASLVFSVLCALMLTFVWFFTWERPREEWSEAALRAE 218
Cdd:PRK11462 155 ATAGGMLSTVLMMPLVNLIGGDNkPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMRED 220
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
41-411 |
1.06e-12 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 69.96 E-value: 1.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 41 GLTPIEATFIFAAARVLDAVVSPLMGFLTDNfgtTWLgkRFGRRKFFILLGIPCV-FSYSLM-WVGDMSFWY-------- 110
Cdd:cd17313 30 GLSHALIGFVWTLGPILGLFVQPLVGSLSDR---CNS--RIGRRRPFILVGAPLAaLGLILIpNAADIGLALgdgprtwa 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 111 ---YLLTYLIFDIVYTMILVPYETLVPEMTDDfKQKTKFSGARISMAQMSAILASFLPGILLTH------FGKDNAISFF 181
Cdd:cd17313 105 lvlFVLGIVLLDFAMNVCQGPVRALLPDLVPP-EQRSKANGIINFMGGLGGVLGYLLGAILWDHnwfgfaLGGNLKVPFY 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 182 YASLVFSVLCALMLTFVwfftwerPREEWSEAALRAEEEKKKLTLGQSLNRLFVELSSTLRiKIFRQHLGMYLGgyiaqd 261
Cdd:cd17313 184 IGAIILLVCVLVTLFFV-------KEPPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSLL-RLLLVIFFWWIA------ 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 262 vFNAVFTYYVVFV--------------LMQEASMASNLLGTMAIFQFLAVIGMIPLCIRFGPAPSYRMVVVLFGLASLSy 327
Cdd:cd17313 250 -FFPFELFFTDYMgeevyhgtsaasshYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMAL- 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 328 avlyyAGLSDVYALLLLISAVAGLGRGGINYVPwntYTYIADVDEVitGQRREGIFAGIMTLTRKASQAGAVMLVGIVMQ 407
Cdd:cd17313 328 -----MALVHNVTVALVLFALGGIGWATININP---YPLVSDYHSE--SGRGQGTDTGLLNLAISLAQILVSLLAGPIID 397
|
....
gi 516289931 408 MSGF 411
Cdd:cd17313 398 VKGY 401
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
32-410 |
4.25e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 67.84 E-value: 4.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 32 LLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFILLGIPCVFSYSLMWVGDmSFWYY 111
Cdd:cd06174 18 LLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD---------RFGRRPVLLLGLLLFALGALLFAFAP-SFWLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 112 LLTYLIFDIVYTMILVPYETLVPEMTDDfKQKTKFSGARISMAQMSAILASFLPGILLTHFGkdnaISFFYASLVFSVLC 191
Cdd:cd06174 88 LLGRFLLGLGSGLIDPAVLALIADLFPE-RERGRALGLLQAFGSVGGILGPLLGGILASSLG----FGWRAVFLIAAALA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 192 ALMLTFVWFFtwerPREEWSEAALRAEEEKKKLTLGQslnrlfvelsstLRIKIFRQHLGMYLGGYIAQDVFNAVFTYYV 271
Cdd:cd06174 163 LLAAILLLLV----VPDPPESARAKNEEASSKSVLKL------------LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 272 VFVLMQEASMASNLLGTMAIFQFLAVIGMIPLCIRFGPAPSYRMVVVLFGLASLSyAVLYYAGLSDVYALLLLISAVAGL 351
Cdd:cd06174 227 PLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMA-LGLALLLLAPSLLLLLLLLLLLGF 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 516289931 352 GRGGINYVPWntyTYIADvdevITGQRREGIFAGIMTLTRKASQAGAVMLVGIVMQMSG 410
Cdd:cd06174 306 GLGGLLPLSF---ALIAE----LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
12-402 |
1.52e-09 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 59.96 E-value: 1.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 12 FAYGSGDFLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDNfgTTWLGKrFGRRK------ 85
Cdd:cd17491 2 IAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDR--TNGCGK-YGRRKswhlig 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 86 -FFILLGIPCVFSYSLMWVGDMSFWYYLLTYL----IFDIVYTMILVPYETLVPEMTDDFKQKTKFSGARISMAQMSAIL 160
Cdd:cd17491 79 tICVLLSFPFIFNPCLGCSDSTSEWAKLVYYGpfiiIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYAFTVIANIT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 161 ASFLPGILLtHFGKDNAI---------SFFYASLVFSVLCALMLTFVWFFTWERPREEwseaalRAEEEKKKLTLGQSLN 231
Cdd:cd17491 159 VYLIAWLLL-QQSSGDSVnptsaqdlpIFRNLSLIVVGIGFLFSLLFHLGTKEPRPPT------DLSTTTNEGEEVTAPE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 232 RLFVELSSTLRIKIFRQHLGMYLGgyiAQDVFNAVFTYYVVFV----LMQEASMASNLLgTMAIFQFLAVIGMIPLCIRF 307
Cdd:cd17491 232 EPRLTWKEWLREPQFYQVALLYMC---TRLIVNLSQVYIPLYLtetlQLPKESIAIVPL-VMYVSGFLTSLVMKPINKKI 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 308 GPAPSYrMVVVLFGLASlSYAVLYYAGLSDVYAlllLISAVAGLGRGG-INYVpwntyTYIADVDEVITGQRREGIFA-G 385
Cdd:cd17491 308 GRKITY-LLGLLFVLGF-CIWVWFQSGSSRTYE---IYGAAVLLGVGSaTLLV-----TSLSMTADLIGTNTESGAFVyG 377
|
410
....*....|....*..
gi 516289931 386 IMTLTRKASQAGAVMLV 402
Cdd:cd17491 378 AMSFTDKLSNGIAVLII 394
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-365 |
2.33e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.97 E-value: 2.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 19 FLGAGTTALTAAWLLYFYTTFcGLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFILLGIPCVFSY 98
Cdd:pfam07690 7 LAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSD---------RFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 99 SLMWVGDmSFWYYLLTYLIFDIVYTMILVPYETLVPEMTDDfKQKTKFSGARISMAQMSAILASFLPGILLTHFGkdnAI 178
Cdd:pfam07690 77 LLLLFAS-SLWLLLVLRVLQGLGAGALFPAALALIADWFPP-EERGRALGLVSAGFGLGAALGPLLGGLLASLFG---WR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 179 SFFYASLVFSVLCALMLTFvwfftWERPREEWSEAALRAEeekkkltlgqslnrlFVELSSTLRIKIFRQHLGMYLGGYI 258
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLL-----PRPPPESKRPKPAEEA---------------RLSLIVAWKALLRDPVLWLLLALLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 259 AQDVFNAVFTYYVVFVLMQEASMASNLLgTMAIFQFLAVIGMIPLCIRFGPAPSYRMVVVLFGLASLSYAVLYYAGLSDV 338
Cdd:pfam07690 212 FGFAFFGLLTYLPLYQEVLGLSALLAGL-LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLS 290
|
330 340
....*....|....*....|....*..
gi 516289931 339 YALLLLISAVAGLGrGGINYVPWNTYT 365
Cdd:pfam07690 291 SLWLLLALLLLGFG-FGLVFPALNALV 316
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-209 |
1.46e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 53.73 E-value: 1.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 19 FLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFILLGIPCVFSY 98
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD---------RIGGRRVLLIVFALMALGL 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 99 SLMWVGDMSFWYYLLTYLIFDIVYTMILVPYETLVPEMTDdfkqkTKFSGARISMAQMSAILASFLPGILLTHFgKDNAI 178
Cdd:COG2223 286 LLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFP-----TKNAGAVYGLVGAAGGLGGFLGPLLFGAL-LDATG 359
|
170 180 190
....*....|....*....|....*....|.
gi 516289931 179 SFFYASLVFSVLCALMLTFVWFFTWERPREE 209
Cdd:COG2223 360 SYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
10-201 |
2.95e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.58 E-value: 2.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 10 NYFAYGSGDFLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFIL 89
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD---------RIGRKPLILI 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 90 LGIPCVFSYSLMWVGDmSFWYYLLTYLIFDIVYTMILVPYETLVPEMTDDFKQKTKFSGARISMAqMSAILASFLPGILL 169
Cdd:cd17325 271 GLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFS-LGMVLGPLLGGFLY 348
|
170 180 190
....*....|....*....|....*....|..
gi 516289931 170 THFGkdnaisFFYASLVFSVLCALMLTFVWFF 201
Cdd:cd17325 349 DAFG------FATPFLAAAALLLLAAVLFLLL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
41-357 |
4.09e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.90 E-value: 4.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 41 GLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFILLGIPCVFSYSLMWVGDmSFWYYLLTYLIFDI 120
Cdd:COG2814 41 GASPAQAGLVVTAYLLGAALGAPLAGRLAD---------RFGRRRVLLLGLLLFALGSLLCALAP-SLWLLLAARFLQGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 121 VYTMILVPYETLVPEMTDDfKQKTKFSGARISMAQMSAILASFLPGILLTHFGkdnaisFFYASLVFSVLCALMLTFVWF 200
Cdd:COG2814 111 GAGALFPAALALIADLVPP-ERRGRALGLLGAGLGLGPALGPLLGGLLADLFG------WRWVFLVNAVLALLALLLLLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 201 FTWERPREEwseaalraeeekkkltlgqsLNRLFVELSSTLRIKIFRQHLGMYLGGYIAQDVFNAVFTYYVVFVLMQEAS 280
Cdd:COG2814 184 LLPESRPAA--------------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516289931 281 MASNLLGTMAIFQFLAVIGMIPLCIRFGPapsYRMVVVLFGLASLSYAVLyyaGLSDVYALLLLISAVAGLGRGGIN 357
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGR---RRLLLIGLLLLALGLLLL---ALAGSLWLLLLALFLLGFGFGLLF 314
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
19-200 |
5.90e-07 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 51.76 E-value: 5.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 19 FLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFILLGIPC-VFS 97
Cdd:cd17369 238 LAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSD---------RVGRRPVYLAGALLAaLFA 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 98 YSLMWV--GDMSFWYYLLTYLIFDIVYTMILVPYETLVPEMtddFKQKTKFSGARISMaQMSAILASFLPGILLTHFGKD 175
Cdd:cd17369 309 FPFFWLldTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAEL---FPTRVRYTGASLGY-QLGAILGGGFAPLIATALVAA 384
|
170 180
....*....|....*....|....*
gi 516289931 176 NAiSFFYASLVFSVLCALMLTFVWF 200
Cdd:cd17369 385 TG-SWWPVALYLAALAVISLVAALF 408
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
42-197 |
1.80e-06 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 50.20 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 42 LTPIEATFIFAAARVLDAVVSPLMGFLTDNfgTTWlgKRFGRRKFFILLGIP-CVFSYSLMWV-----GDMSFWyYLLTY 115
Cdd:cd17451 32 LDPFYASIILFVGRAWDAITDPTVGFFVSK--SPW--TRFGRLMPWIIFSTPfAVLSYFLIWFvpdfsQGKVMW-YLLFY 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 116 LIFDIVYTMILVPYETLVPEMTDDFKQKTKFSGARISMAQMSAILASFLPGILLthfgkdNAISFFYASLVFS---VLCA 192
Cdd:cd17451 107 CLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIV------GMAAYMIAAGVICaiyVLCA 180
|
....*
gi 516289931 193 LMLTF 197
Cdd:cd17451 181 IILFL 185
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
41-354 |
2.13e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.88 E-value: 2.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 41 GLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFILLGIPCVFSYSLMWVGDmSFWYYLLTYLIFDI 120
Cdd:COG2223 36 GLSAAQLGLLFAIPVLVGALLRIPLGFLVD---------RFGPRRVLLIGLLLLGIGLLLLALAV-SYWLLLLLGLLLGI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 121 VYTMILVPYETLVPEMTDDfKQKTKFSGARISMAQMSAILASFLPGILLTHFGkdnaisFFYASLVFSVLCALMLTFVWF 200
Cdd:COG2223 106 GGGGSFAVGIALVSKWFPP-DRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG------WRNAFLILGILLLVVAVLAWL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 201 FTWERPREEWSEAALRaeeekkkltlgqslnrlFVELSSTLRIKIFRQHLGMYLGGYIAQDVFNAVFTYYVVFVLMQEAS 280
Cdd:COG2223 179 FLRDPPAGAAAAAKAS-----------------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516289931 281 MASNLLGTMAIFQFLAVIGMIPLCIRFGPApsyRMVVVLFGLASLSYAVLYYAGLSDV--YALLLLISAVAGLGRG 354
Cdd:COG2223 242 TAGLLAALFALLGALGRPLGGWLSDRIGGR---RVLLIVFALMALGLLLLALALGSLWlfLVLFLLLGLALGGGNG 314
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-411 |
3.58e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.11 E-value: 3.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 41 GLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFIL-LGIPCVFSYSLMWVGdmSFWYYLLTYLIFD 119
Cdd:cd17325 27 GASVAQIGLIVAAYALAQLLFSPPAGRLSD---------RFGRKRLLLLgLLLLAVSTLLFAFAT--SYWQLLLARFLQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 120 IVYTMILVPYETLVPEMTDDfKQKTKFSGARISMAQMSAILASFLPGILLTHFGkdnaisFFYASLVFSVLCALMLTFVW 199
Cdd:cd17325 96 LASAAVWPAAMALIADIAPP-EERGRAMGIFSSAIGLGFLIGPLLGGLLADALG------YRAPFLVCAALALLALVLAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 200 FFTWERPREEWSEAALRAEEEKKKLTLGQSLNRLFVelsstlrikifrqhLGMYLGGYIAQDVFNAVFTYYVVFVLMQEA 279
Cdd:cd17325 169 LLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLAL--------------FLAIFVLAFAFGALEPFLPLYAAELGGLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 280 SMASNLLGTMAIFQFLAVIGMIPLCIRFGPapsYRMVVVLFGLASLSYAVLyyaGLSDVYALLLLISAVAGLGrGGINYV 359
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGKLSDRIGR---KPLILIGLLLSAVALLLL---PLATSFWLLLLLLALLGLG-LGLVFP 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 516289931 360 PWNtyTYIADvdevITGQRREGIFAGIMTLTRKASQAGAVMLVGIVMQMSGF 411
Cdd:cd17325 308 ATL--ALLAD----IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
19-197 |
1.59e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.21 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 19 FLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFILLGIPC-VFS 97
Cdd:cd17316 187 FFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD---------RIGRKKTLVIGLILSgILA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 98 YSLMWVGDMSFWYYLLTYLIFDIVYTMILVPYETLVPEMtddFKQKTKFSGARISMAqMSAILASFLPGILLTHFGKDNA 177
Cdd:cd17316 258 LPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL---FPTEVRATGVGLSYN-LGRLGGGGAPPLIALLLASTGG 333
|
170 180
....*....|....*....|
gi 516289931 178 ISFFYASLVFSVLCALMLTF 197
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
59-354 |
4.91e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.64 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 59 AVVSPLMGFLTDnfgttwlgkRFGRRK-------FFILLGIPCVFSYSLMWVgdmsfwyyLLTYLIFDIVYTMILVPYET 131
Cdd:cd17473 49 ALFAPLAGWLAD---------RFGRKRlliagllLYGIGGVAGLFLDSLYAL--------LASRALLGIGVAGIMTLATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 132 LVPEMTDDfKQKTKFSGARISMAQMSAILASFLPGILLThfgkdnaISFFYASLVFSVLCALMLtFVWFFTWERPREEWS 211
Cdd:cd17473 112 LIGDYFEG-EERAKMLGLQSAAMSLGGVVFLLLGGALAE-------IGWRAPFLVYLLALPVLI-LVLLFLPEPARKSKS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 212 EAALRAEEEKKKLTlgqslnrlfvelsstlrikifRQHLGMYLGGYIAQDVFNAVFTY---YVVFVLMQEASMASNLLGT 288
Cdd:cd17473 183 AASPGAATAAALPW---------------------KRVLPIYFLAFLAMLLFYVIPIQlpfLLQERGGGSAALIGLALAI 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516289931 289 MAIFQFLAVIGMIPLCIRFGPApsyRMVVVLFGLASLSYAVLyyaGLSDVYALLLLISAVAGLGRG 354
Cdd:cd17473 242 ASLAGAIGALLFGRLKRRLGKR---RLLAIGFALMALGFLLL---ALASGLWVVLLGAILAGLGFG 301
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-195 |
8.32e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 8.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 6 IGLANYFAYGSGDFLGAGTTALTAAWLLYFYTTFCGLTPIEATFIFAAARVLDAVVSPLMGFLTDNFGttwlgkRFGRRK 85
Cdd:COG2271 177 LALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG------RRRKLV 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 86 FFILLGIPCVFSYSLMWVGdmSFWYYLLTYLIFDIVYTMILVPYETLVPEMTDdfkqkTKFSGARISM----AQMSAILA 161
Cdd:COG2271 251 LAIGLLLAALALLLLALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELFP-----KKARGTASGLvntfGFLGGALG 323
|
170 180 190
....*....|....*....|....*....|....
gi 516289931 162 SFLPGILLTHFGKDNAISFFYASLVFSVLCALML 195
Cdd:COG2271 324 PLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
44-174 |
9.59e-05 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 44.77 E-value: 9.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 44 PIEATFIFAAARVLDAVVSPLMGFLTDNFGTTwlgkRFGRRKFFILLGIP-CVFSYSLMWV----GDMSFWYYLLTYLIF 118
Cdd:cd17392 34 AFSVSLILFVGRVWDAVTDPLVGYFISRSQRT----GIGRLMPWIVFSTPlIILAYFFLWFlppfTSLSGLWYLTFYCLF 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 516289931 119 DIVYTMILVPYETLVPEMTDDFKQKTKFSGARISMAQMSAILASFLPGILLTHFGK 174
Cdd:cd17392 110 ETFMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMGATIQGQIVGVAHR 165
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
41-217 |
1.26e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.03 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 41 GLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFILLGIPC-VFSYSLMWVGDMSFWYYLLTYLIFD 119
Cdd:cd17335 28 GLSPTQIGILIGIRPFVRFLSAPLWGALAD---------RFGKRKALLLLSLLAaVLFFLSLFFVAQIFWLLLLLVILGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 120 IVYTMILVPYETLVPEMTDDFKQKtkFSGARIsMAQMSAILASFLPGILLTHFGKD-NAISFFYASLVFsVLCALMLTFV 198
Cdd:cd17335 99 FFSAPVVPLVDSITLQYLGEERER--YGKQRL-WGSIGFGIAALLVGILIDRSSTYkNYTIAFYVFAVL-MLLALLLALK 174
|
170
....*....|....*....
gi 516289931 199 WFFTWERPREEWSEAALRA 217
Cdd:cd17335 175 FPFRPKHPEPNENTGGLLA 193
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
41-356 |
2.20e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.63 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 41 GLTPIEATFIFAAARVLDAVVSPLMGfltdnfgttWLGKRFG-RRKFFILLGIPCVFSYSLMWVGdmSFWYYLLTYLIFD 119
Cdd:COG2807 49 GLSATQAGLLTTLPLLAFGLFAPLAP---------RLARRFGlERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 120 IVYTMILVPYETLVpemTDDFKQKTKF-SGARISMAQMSAILASFLPGILLTHFGKDNAIsffyasLVFSVLCALMLTFV 198
Cdd:COG2807 118 AGIAVGNVLLPGLI---KRWFPDRVGLmTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL------AVWALLALLALLLW 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 199 WFFTWERPREEWSEAALRAeeekkkltlgqslnrlfveLSSTLRIKIFRQhLGMYLGGYiaqdvfnaVFTYYVVFVLMQE 278
Cdd:COG2807 189 LPLLRRRPAAAAAAPAAAS-------------------LRSLWRSPLAWL-LTLFFGLQ--------SLLYYAVVAWLPP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 279 --------ASMASNLLGTMAIFQFLAVIGMIPLCIRFGpaPSYRMVVVLFGLASLSYAVLYYAGLSdvyaLLLLISAVAG 350
Cdd:COG2807 241 ilrdaglsAATAGLLLSLFQLAGIPGSLLVPLLADRLG--DRRPLLLLLGLLGLAGLLGLLLAPGS----LPWLWAVLLG 314
|
....*.
gi 516289931 351 LGRGGI 356
Cdd:COG2807 315 LGQGGL 320
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
40-356 |
3.03e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.90 E-value: 3.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 40 CGLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFILLGIPCVFSYSLMWVGDMSFWYYLLTYLIFD 119
Cdd:cd17353 33 LGWSLASVALAFTLTIVFLAISAPFAGRLVD---------RGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 120 IVYTMIlvpYETLVPEMTDDFKQKTKFSGARISMA-QMSAILASFLPGILLTHFGKDNAisFFYASLVFsvlcALMLTFV 198
Cdd:cd17353 104 IGAGIG---YITPVSTAVKWFPDKRGLATGIVIAGfGLGSLIFSPLIAYLINTVGVPTT--FLILGIIF----LIIIVIG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 199 WFFTwERPREEWSEAALRAEEEKKKLTLGQslnrlfVELSSTLRIKIFRQHLGMYLGGYIAQDVFNAVFTYYVVFVLMQE 278
Cdd:cd17353 175 AFLI-RDPPKGWVPPGVDPLANNAENSPRD------YTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLD 247
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516289931 279 ASMASNLLGTMAIFQFLAVIGMIPLCIRFGPapsYRMVVVLFGLASLSYAVLYYAGlsDVYALLLLISAVAGLGRGGI 356
Cdd:cd17353 248 AGIAALAVSILSIFNGGGRPFWGWLSDKIGR---KNTLSIAFLIQGVAMFLLPFIG--SVAVLFVLGVALIGFCYGGG 320
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
19-199 |
3.62e-03 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 39.54 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 19 FLGAGTTALTAAWLLYFYTTfcGLTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRKFFILLGIPC---V 95
Cdd:pfam12832 10 FYFAALGCLLPYWGLYLRSI--GLNPSEIGLITAILPLTRILAPPIWGWLAD---------RTGKRKAVVRLASILaavL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 96 FSYSLMWVGDMSFWYYLLTYLIFDIVYTMILVPYETLVPEMTDDfkqKTKFSGARISMAQMSAILASFLPGILLTHFGKD 175
Cdd:pfam12832 79 FLSVLFIPISLTFWWLALLVVLFSFFWNAILPQFEVATLQHLGE---KRKDYGRQRLWGSVGFALSVFGLGALFDHYSVG 155
|
170 180
....*....|....*....|....*...
gi 516289931 176 N----AISFFYASLVFSVLCALMLTFVW 199
Cdd:pfam12832 156 LlpsvLFYLFAALMLLSLLLPLAPPEME 183
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-410 |
5.05e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.14 E-value: 5.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 20 LGAGTTALTAAWLLYFYTTfcglTPIEATFIFAAARVLDAVVSPLMGFLTDnfgttwlgkRFGRRK----FFILLGIPCV 95
Cdd:cd06173 13 LGDWIFTVALPWLVLQLTG----SALLVGLVLAAFFLPFLLFSPFAGVLAD---------RFDRRRllilADLLRALLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 96 FSYSLMWVGDMSFWYYLLTYLIFDIVYTMILVPYETLVPEMTDDfKQKTKFSGARISMAQMSAILASFLPGILLTHFGkd 175
Cdd:cd06173 80 VLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPK-EQLVRANALNSLATQLARIIGPALGGLLVALLG-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 176 naISFFYASLVFSVLCALMLTFVWFFTWERPREEWSEAALRAEEEKkkltlgqslnRLFVELSSTLRIKIFRQHLGMYLG 255
Cdd:cd06173 157 --PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG----------LRYLRRSPLLRLLLLALALFALLG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516289931 256 GyiaqdVFNAVFTYYVVFVLMQEASMASNLLGTMAIFqflAVIGMIpLCIRFGPAPSY-RMVVVLFGLASLSYAVLyyaG 334
Cdd:cd06173 225 G-----ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVG---ALLGAL-LLGRLSKRRRRgRLLLIGALLLGLALLVL---G 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516289931 335 LSDVYALLLLISAVAGLGrGGINYVPWNTYtyiadVDEVITGQRREGIFAGIMTLTRKASQAGAVmLVGIVMQMSG 410
Cdd:cd06173 293 LSPSLWLLLAALFLLGLA-GGLFNVPLNTL-----LQLRVPDELRGRVFSVYNALNSGAMPLGAL-LAGLLADALG 361
|
|
| |
