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Conserved domains on  [gi|516347286|ref|WP_017737319|]
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MetQ/NlpA family ABC transporter substrate-binding protein [Pseudomonas sp. CBZ-4]

Protein Classification

MetQ/NlpA family ABC transporter substrate-binding protein( domain architecture ID 10194440)

MetQ/NlpA family ABC transporter substrate-binding protein functions as the initial receptor in the ABC transport of one or more from a variety of substrates including methionine; similar to Bacillus subtilis methionine-binding lipoprotein MetQ

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PBP2_lipoprotein_Tp32 cd13597
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ...
 23-260 7.89e-111

The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


:

Pssm-ID: 270315  Cd Length: 236  Bit Score: 318.84  E-value: 7.89e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  23 ALRVAADPIPHAQILEYVQKLDPS--LKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQEQALGQKFTVAATVHIE 100
Cdd:cd13597    1 TLKVGATPVPHAEILEFIKPELKKqgIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 101 PLGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNDAAkdqaTPKDIAENPKHLKILEIESPQIP 180
Cdd:cd13597   81 PMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITLKDGAGLTA----TVKDIVKNPKNLKFKELEAAQLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 181 RALDDVDLAVINGNFALEAGLEPAKDALGLEAAKGNPYANILVTTPKLAQDPRIEQLAKDLRSPQVAKFISEKYAGSVIP 260
Cdd:cd13597  157 RSLDDVDAAVINGNYALEAGLNPKKDALALEDKDNSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDGAVVP 236
 
Name Accession Description Interval E-value
PBP2_lipoprotein_Tp32 cd13597
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ...
 23-260 7.89e-111

The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270315  Cd Length: 236  Bit Score: 318.84  E-value: 7.89e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  23 ALRVAADPIPHAQILEYVQKLDPS--LKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQEQALGQKFTVAATVHIE 100
Cdd:cd13597    1 TLKVGATPVPHAEILEFIKPELKKqgIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 101 PLGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNDAAkdqaTPKDIAENPKHLKILEIESPQIP 180
Cdd:cd13597   81 PMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITLKDGAGLTA----TVKDIVKNPKNLKFKELEAAQLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 181 RALDDVDLAVINGNFALEAGLEPAKDALGLEAAKGNPYANILVTTPKLAQDPRIEQLAKDLRSPQVAKFISEKYAGSVIP 260
Cdd:cd13597  157 RSLDDVDAAVINGNYALEAGLNPKKDALALEDKDNSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDGAVVP 236
NlpA COG1464
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ...
 6-261 8.90e-106

ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];


Pssm-ID: 441073 [Multi-domain]  Cd Length: 270  Bit Score: 307.42  E-value: 8.90e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286   6 ALTLAVLLASFNVSAADA-------LRVAADPIPHAQILEYVQKL--DPSLKLKIIEIPSGVNSNELLAHGDVDANYFQH 76
Cdd:COG1464   10 ALALALALAACGSSSAAAaaadkktIKVGATPGPHAEILEVVKPElaKKGIDLEIVEFTDYVQPNEALADGEIDANYFQH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  77 LPYLASQEQALGQKFTVAATVHIEPLGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNdaakDQ 156
Cdd:COG1464   90 IPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLKDGVG----LL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 157 ATPKDIAENPKHLKILEIESPQIPRALDDVDLAVINGNFALEAGLEPAKDALGLEaAKGNPYANILVTTPKLAQDPRIEQ 236
Cdd:COG1464  166 ATVKDITENPKNLKFVELDAAQLPRSLDDVDAAVINGNYALEAGLDPTKDALFLE-DKDSPYANIIVVREDDKDDPAIKK 244

                        250       260
                 ....*....|....*....|....*
gi 516347286 237 LAKDLRSPQVAKFISEKYAGSVIPV 261
Cdd:COG1464  245 LVEAYQSDEVKKFIEEKYKGAVVPA 269
Lipoprotein_9 pfam03180
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ...
 24-262 2.70e-91

NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.


Pssm-ID: 427184  Cd Length: 236  Bit Score: 269.52  E-value: 2.70e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286   24 LRVAADPIPHAQILEYVQKL--DPSLKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQEQALGQKFTVAATVHIEP 101
Cdd:pfam03180   1 LKVGATPGPHAEILEVAKPLlkKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  102 LGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNDAakdqATPKDIAENPKHLKILEIESPQIPR 181
Cdd:pfam03180  81 MGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDGKGLL----ATVKDITENPKNLKIKELEAAQLPR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  182 ALDDVDLAVINGNFALEAGLEPAKDALGLEaAKGNPYANILVTTPKLAQDPRIEQLAKDLRSPQVAKFISEKYAGSVIPV 261
Cdd:pfam03180 157 ALDDVDAAVINTNYALEAGLNPKKDALFEE-DKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPA 235


                  .
gi 516347286  262 A 262
Cdd:pfam03180 236 W 236
TIGR00363 TIGR00363
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ...
 10-260 4.66e-50

lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]


Pssm-ID: 129460  Cd Length: 258  Bit Score: 165.07  E-value: 4.66e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286   10 AVLLASFNVSAADALRVAADPI--PHAQILEYVQKLDPS---LKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQE 84
Cdd:TIGR00363   4 ALVLTGCKQDKKDPLHIKVGVIsgAEQQVAEVAAKVAKEkygLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286   85 QALGQKFTVAATVHIEPLGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKpgfnDAAKDQATPKDIAE 164
Cdd:TIGR00363  84 KAKGYKLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLK----DGNGLLPTVLDIVE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  165 NPKHLKILEIESPQIPRALDD--VDLAVINGNFALEAGLEPAKDALGLEaAKGNPYANILVTTPKLAQDPRIEQLAKDLR 242
Cdd:TIGR00363 160 NPKKLNITELETSQLPRALDDpkVDLAVINTTYAGQVGLNPQDDGVFVE-DKDSPYVNIIVSREDNKDAENVKDFIQSYQ 238

                         250
                  ....*....|....*...
gi 516347286  243 SPQVAKFISEKYAGSVIP 260
Cdd:TIGR00363 239 SEEVYQAAQKHFNGGAVK 256
PRK09861 PRK09861
lipoprotein NlpA;
5-260 1.10e-49

lipoprotein NlpA;


Pssm-ID: 182119  Cd Length: 272  Bit Score: 164.81  E-value: 1.10e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286   5 SALTLA-VLLASFNVSAADALRVAADPIPHAQ-----ILEYVQKLDPSLKLKIIEIPSGVNSNELLAHGDVDANYFQHLP 78
Cdd:PRK09861  12 AALLLAgILLAGCDQSSSDAKHIKVGVINGAEqdvaeVAKKVAKEKYGLDVELVGFSGSLLPNDATNHGELDANVFQHRP 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  79 YLASQEQALGQKFTVAATVHIEPLGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNDAakdqAT 158
Cdd:PRK09861  92 FLEQDNQAHGYKLVAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLL----PT 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 159 PKDIAENPKHLKILEIESPQIPRALDD--VDLAVINGNFALEAGLEPAKDALGLEaAKGNPYANILVTTPKLAQDPRIEQ 236
Cdd:PRK09861 168 ALDITDNPRHLQIMELEGAQLPRVLDDpkVDVAIISTTYIQQTGLSPVHDSVFIE-DKNSPYVNILVAREDNKNAENVKE 246

                        250       260
                 ....*....|....*....|....
gi 516347286 237 LAKDLRSPQVAKFISEKYAGSVIP 260
Cdd:PRK09861 247 FLQSYQSPEVAKAAETIFNGGAVP 270
 
Name Accession Description Interval E-value
PBP2_lipoprotein_Tp32 cd13597
The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum ...
 23-260 7.89e-111

The substrate-binding domain of the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum binds L-methionine; the type 2 periplasmic-binding protein fold; This group includes the lipoprotein Tp32, a periplasmic component of a methionine uptake transporter system, and its closely related homologs. The Tp32 has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus it belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270315  Cd Length: 236  Bit Score: 318.84  E-value: 7.89e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  23 ALRVAADPIPHAQILEYVQKLDPS--LKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQEQALGQKFTVAATVHIE 100
Cdd:cd13597    1 TLKVGATPVPHAEILEFIKPELKKqgIDLEIVEFTDYVQPNTALADGELDANYFQHVPYLESFNKEKGYDLVAVAGVHLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 101 PLGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNDAAkdqaTPKDIAENPKHLKILEIESPQIP 180
Cdd:cd13597   81 PMGLYSKKYKSLEDLPDGATIAIPNDPTNQGRALLLLEEAGLITLKDGAGLTA----TVKDIVKNPKNLKFKELEAAQLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 181 RALDDVDLAVINGNFALEAGLEPAKDALGLEAAKGNPYANILVTTPKLAQDPRIEQLAKDLRSPQVAKFISEKYAGSVIP 260
Cdd:cd13597  157 RSLDDVDAAVINGNYALEAGLNPKKDALALEDKDNSPYANILVVRKGNEDDPRIKKLAKALQSDEVKDFIEEKYDGAVVP 236
NlpA COG1464
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ...
 6-261 8.90e-106

ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];


Pssm-ID: 441073 [Multi-domain]  Cd Length: 270  Bit Score: 307.42  E-value: 8.90e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286   6 ALTLAVLLASFNVSAADA-------LRVAADPIPHAQILEYVQKL--DPSLKLKIIEIPSGVNSNELLAHGDVDANYFQH 76
Cdd:COG1464   10 ALALALALAACGSSSAAAaaadkktIKVGATPGPHAEILEVVKPElaKKGIDLEIVEFTDYVQPNEALADGEIDANYFQH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  77 LPYLASQEQALGQKFTVAATVHIEPLGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNdaakDQ 156
Cdd:COG1464   90 IPYLDNFNKENGYDLVPVGKTHIEPMGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLKDGVG----LL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 157 ATPKDIAENPKHLKILEIESPQIPRALDDVDLAVINGNFALEAGLEPAKDALGLEaAKGNPYANILVTTPKLAQDPRIEQ 236
Cdd:COG1464  166 ATVKDITENPKNLKFVELDAAQLPRSLDDVDAAVINGNYALEAGLDPTKDALFLE-DKDSPYANIIVVREDDKDDPAIKK 244

                        250       260
                 ....*....|....*....|....*
gi 516347286 237 LAKDLRSPQVAKFISEKYAGSVIPV 261
Cdd:COG1464  245 LVEAYQSDEVKKFIEEKYKGAVVPA 269
Lipoprotein_9 pfam03180
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ...
 24-262 2.70e-91

NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.


Pssm-ID: 427184  Cd Length: 236  Bit Score: 269.52  E-value: 2.70e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286   24 LRVAADPIPHAQILEYVQKL--DPSLKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQEQALGQKFTVAATVHIEP 101
Cdd:pfam03180   1 LKVGATPGPHAEILEVAKPLlkKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  102 LGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNDAakdqATPKDIAENPKHLKILEIESPQIPR 181
Cdd:pfam03180  81 MGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKDGKGLL----ATVKDITENPKNLKIKELEAAQLPR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  182 ALDDVDLAVINGNFALEAGLEPAKDALGLEaAKGNPYANILVTTPKLAQDPRIEQLAKDLRSPQVAKFISEKYAGSVIPV 261
Cdd:pfam03180 157 ALDDVDAAVINTNYALEAGLNPKKDALFEE-DKDSPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGGAVIPA 235


                  .
gi 516347286  262 A 262
Cdd:pfam03180 236 W 236
PBP2_lipoprotein_MetQ_like cd13526
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ...
 24-252 2.67e-75

The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270244  Cd Length: 228  Bit Score: 228.74  E-value: 2.67e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  24 LRVAADPIPHAQILEYVQKL--DPSLKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQEQALGQKFTVAATVHIEP 101
Cdd:cd13526    2 LKIGVTAGPSADVVEAAKKEakKKGYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLVKVGKTVIAP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 102 LGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNdaakDQATPKDIAENPKHLKILEIESPQIPR 181
Cdd:cd13526   82 IGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKLKDGVG----LFATVLDITENPKNLEIVEVDAAQLPR 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516347286 182 ALDDVDLAVINGNFALEAGLEPAKDALGLEAAKGNPYANILVTTPKLAQDPRIEQLAKDLRSPQVAKFISE 252
Cdd:cd13526  158 SLDDVDAAVINGNYAISAGLDPRKDAIFLEDSDASPYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLKE 228
PBP2_lipoprotein_IlpA_like cd13598
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar ...
 24-252 6.57e-69

Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar lipoproteins; the type 2 periplasmic binding protein fold; This group includes the IlpA protein which has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270316  Cd Length: 227  Bit Score: 212.21  E-value: 6.57e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  24 LRVAADPIPHAQILEYVQK--LDPSLKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQEQALGQKFTVAATVHIEP 101
Cdd:cd13598    2 IKVGVIRGPDAQIWEVVQKvaKEKGLDVELVTFNDYAQPNEALAAGDLDANAFQHKPYLDAQIKARGYKLVIVGNTFVYP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 102 LGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGfndaAKDQATPKDIAENPKHLKILEIESPQIPR 181
Cdd:cd13598   82 IGLYSKKIKSLAELPNGATVAIPNDPSNEGRALLLLQKEGLIKLKDG----VGLLATVRDIAENPKKLKIVELDAGQLPR 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516347286 182 ALDDVDLAVINGNFALEAGLEPAKDALGLEAAKgNPYANILVTTPKLAQDPRIEQLAKDLRSPQVAKFISE 252
Cdd:cd13598  158 ALDDVDLAAINTDYASKAGLTPARDAIAQEDKR-SPYANVIAVREDDKDAPWVKTLVQAYQSEEVKAFALK 227
PBP2_lipoprotein_GmpC cd13596
The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; ...
 35-252 1.61e-57

The periplasmic substrate-binding domain of the membrane-associated lipoprotein-9 GmpC; contains the type 2 periplasmic-binding protein fold; This group includes the membrane-associated lipoprotein-9 from Staphylococcus aureus that binds the dipeptide glycylmethionine (GlyMet). The lipoprotein-9 has both structural and sequential homology to the MetQ family of substrate-binding protein. The GlyMet binding protein belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270314  Cd Length: 230  Bit Score: 183.33  E-value: 1.61e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  35 QILEYVQKL--DPSLKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQEQALGQKFTVAATVHIEPLGIYSRRHKSF 112
Cdd:cd13596   12 DIWDKIVEEaeEAGIKLELVNFSDYSQPNKALNDGDIDLNAFQHYAYLVQYNSKNNADLTAIGDTVIAPMGIYSKKITSV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 113 DQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNDAakdqATPKDIAENPKHLKILEIESPQIPRALDDVDLAVIN 192
Cdd:cd13596   92 DELPDGAKIAIPNDPSNLSRALFILQAAGLIKLKKDAGDF----PTVNDITENPKNLEIVPVDADQVYRALNDVDAAVIN 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516347286 193 GNFALEAGLEPAKDALGLE---AAKGNPYANILVTTPKLAQDPRIEQLAKDLRSPQVAKFISE 252
Cdd:cd13596  168 NTFALDAGLDPKKDAIFLEdpsSYGSKPYINLIAVREEDKDNPLYKKLVETYHDERVQKAVEE 230
TIGR00363 TIGR00363
lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for ...
 10-260 4.66e-50

lipoprotein, YaeC family; This family of putative lipoproteins contains a consensus site for lipoprotein signal sequence cleavage. Included in this family is the E. coli hypothetical protein yaeC. About half of the proteins between the noise and trusted cutoffs contain the consensus lipoprotein signature and may belong to this family. [Cell envelope, Other]


Pssm-ID: 129460  Cd Length: 258  Bit Score: 165.07  E-value: 4.66e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286   10 AVLLASFNVSAADALRVAADPI--PHAQILEYVQKLDPS---LKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQE 84
Cdd:TIGR00363   4 ALVLTGCKQDKKDPLHIKVGVIsgAEQQVAEVAAKVAKEkygLDVELVEFNDYALPNEAVSKGDLDANAFQHKPYLDQDA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286   85 QALGQKFTVAATVHIEPLGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKpgfnDAAKDQATPKDIAE 164
Cdd:TIGR00363  84 KAKGYKLVAVGNTFVYPLAGYSKKIKNVNELQDGAKVAVPNDPTNLGRALLLLQKQGLIKLK----DGNGLLPTVLDIVE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  165 NPKHLKILEIESPQIPRALDD--VDLAVINGNFALEAGLEPAKDALGLEaAKGNPYANILVTTPKLAQDPRIEQLAKDLR 242
Cdd:TIGR00363 160 NPKKLNITELETSQLPRALDDpkVDLAVINTTYAGQVGLNPQDDGVFVE-DKDSPYVNIIVSREDNKDAENVKDFIQSYQ 238

                         250
                  ....*....|....*...
gi 516347286  243 SPQVAKFISEKYAGSVIP 260
Cdd:TIGR00363 239 SEEVYQAAQKHFNGGAVK 256
PRK09861 PRK09861
lipoprotein NlpA;
5-260 1.10e-49

lipoprotein NlpA;


Pssm-ID: 182119  Cd Length: 272  Bit Score: 164.81  E-value: 1.10e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286   5 SALTLA-VLLASFNVSAADALRVAADPIPHAQ-----ILEYVQKLDPSLKLKIIEIPSGVNSNELLAHGDVDANYFQHLP 78
Cdd:PRK09861  12 AALLLAgILLAGCDQSSSDAKHIKVGVINGAEqdvaeVAKKVAKEKYGLDVELVGFSGSLLPNDATNHGELDANVFQHRP 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  79 YLASQEQALGQKFTVAATVHIEPLGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNDAakdqAT 158
Cdd:PRK09861  92 FLEQDNQAHGYKLVAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLL----PT 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 159 PKDIAENPKHLKILEIESPQIPRALDD--VDLAVINGNFALEAGLEPAKDALGLEaAKGNPYANILVTTPKLAQDPRIEQ 236
Cdd:PRK09861 168 ALDITDNPRHLQIMELEGAQLPRVLDDpkVDVAIISTTYIQQTGLSPVHDSVFIE-DKNSPYVNILVAREDNKNAENVKE 246

                        250       260
                 ....*....|....*....|....
gi 516347286 237 LAKDLRSPQVAKFISEKYAGSVIP 260
Cdd:PRK09861 247 FLQSYQSPEVAKAAETIFNGGAVP 270
PBP2_lipoprotein_like_1 cd13600
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; ...
 24-252 6.12e-48

Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; the type 2 periplasmic binding protein fold; This subgroup shares significant sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270318  Cd Length: 228  Bit Score: 158.65  E-value: 6.12e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  24 LRVAADPIPHAQILEYV-QKLDPS-LKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQEQALGQKFTVAATVHIEP 101
Cdd:cd13600    2 LKVATNSGPMTEILEYIaAELAPDgITIEPVQVSDYVQANRAVAAGEIDANFFQHQPFMEQFNEANGFELVAVQPIYHWA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 102 LGIYSRRHKSFDQVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNdaaKDQATPKDIAENPKHLKILEIESPQIPR 181
Cdd:cd13600   82 FGFYSKKYKSVEDLPDGAKVAIPNDPANQARALLLLQRAGLITLKPGVD---PTTATLADIVTNPKNLKFTEVDLLALPR 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516347286 182 ALDDVDLAVINGNFALEAGLePAKDALGLEAAKGNPYANILVTTPKLAQDPRIEQLAKDLRSPQVAKFISE 252
Cdd:cd13600  159 ALDDVDLAFGYPSYFDAAGL-TPKDGILLEEPDAKRFAIQLVAREDNKDSPKIKKLKEAFTDPRVRKFLET 228
PBP2_lipoprotein_Gna1946 cd13599
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 ...
 48-252 6.81e-48

The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold; Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270317  Cd Length: 228  Bit Score: 158.71  E-value: 6.81e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  48 KLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQEQALGQKFTVAATVHIEPLGIYSRRHKSFDQVPDKGTVAVPNNV 127
Cdd:cd13599   29 EVKLKEFTDYVQPNNALANGEIDANVFQHKPYLDAFNKENGLDLVGIVQVPTPPMGLYSNKHKSLEEVKDGATVAIPNDP 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 128 TNLSRALYLLQANGLIKLKPGFNDAakdQATPKDIAENPKHLKILEIESPQIPRALDDVDLAVINGNFALEAGLEPaKDA 207
Cdd:cd13599  109 SNLARALVMLQDLGWITLKDNIDPL---KASVNDIAENPKNIKIVELEAAQLPRSLDDVDFAAIQGNFAISSGIKL-TSA 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 516347286 208 LGLEAAKgNPYANILVTTPKLAQDPRIEQLAKDLRSPQVAKFISE 252
Cdd:cd13599  185 LALEEMT-DPYVNVVAVKTADKDKQFAKDVTAAYNSDAFKAYIHA 228
metQ PRK11063
D-methionine ABC transporter substrate-binding protein MetQ;
34-259 2.40e-47

D-methionine ABC transporter substrate-binding protein MetQ;


Pssm-ID: 182939 [Multi-domain]  Cd Length: 271  Bit Score: 158.39  E-value: 2.40e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286  34 AQILEYVQKLDPSLKLKIIEIPSGVNSNELLAHGDVDANYFQHLPYLASQEQALGQKFTVAATVHIEPLGIYSRRHKSFD 113
Cdd:PRK11063  46 AEVAQKVAKEKYGLDVELVTFNDYVLPNEALSKGDIDANAFQHKPYLDQQIKDRGYKLVAVGNTFVYPIAGYSKKIKSLD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516347286 114 QVPDKGTVAVPNNVTNLSRALYLLQANGLIKLKPGFNDAakdqATPKDIAENPKHLKILEIESPQIPRALDD--VDLAVI 191
Cdd:PRK11063 126 ELQDGSQVAVPNDPTNLGRSLLLLQKVGLIKLKDGVGLL----PTVLDIVENPKNLKIVELEAPQLPRSLDDaqIALAVI 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516347286 192 NGNFALEAGLEPAKDALGLEaAKGNPYANILVTTPKLAQDPRIEQLAKDLRSPQVAKFISEKYAGSVI 259
Cdd:PRK11063 202 NTTYASQIGLTPAKDGIFVE-DKDSPYVNLIVAREDNKDAENVKKFVQAYQSDEVYEAANKVFNGGAV 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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