|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
5-388 |
0e+00 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 516.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 5 VMMALVIIFLDAMGIGIIMPVLPALLREFVG-KANVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATL 83
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGdSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 84 DYALMATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQAPFMF 163
Cdd:cd17388 81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 164 AAAINGLAFLVSLFILHETHNANQVSDELKNETINETTSSIREMISPLSGLLVVFFIIQLIGQIPATLWVLFGEERFAWD 243
Cdd:cd17388 161 AAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 244 GVMVGVSLAVFGLTHALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACGGITLPALQGII 323
Cdd:cd17388 241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516391490 324 SVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETWNGWVWIIGCGLYVVALIILRFFH 388
Cdd:cd17388 321 SRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLAYRFF 385
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
8-386 |
4.88e-78 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 244.80 E-value: 4.88e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 8 ALVIIFLDAMGIGIIMPVLPALLREFVGKANVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYAL 87
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 88 MATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQL-SVQAPFMFAAA 166
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPyGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 167 INGLAFLVSLFILhethnanqvsdelknetinettssiremiSPLSGLLVVFFIIQLIGQIPATLWVLFGEERFAWDGVM 246
Cdd:cd17330 161 LALLNLVLVLFFL-----------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQ 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 247 VGVSLAVFGLTHALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVIT-QSWMVWPVLLLLACGGITLPALQGIISV 325
Cdd:cd17330 212 IGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALSALLSK 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516391490 326 RVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSAtreTWNGWVWIIGCGLYVVALIILRF 386
Cdd:cd17330 292 SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSF---LGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-360 |
7.45e-41 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 148.49 E-value: 7.45e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 9 LVIIFLDAMGIGIIMPVLPALLREFvgKANVAEnYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALM 88
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESL--GASVAQ-IGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 89 ATASVVWVLYLGRLIAGI-TGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAPFMFAAA 166
Cdd:cd17325 79 AFATSYWQLLLARFLQGLaSAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLlADALGYRAPFLVCAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 167 INGLAFLVSLFILHETHnaNQVSDELKNETINETTSSIREMISPLSGLLVVFFIIQLIGQIPATLWVLFGEERFAWDGVM 246
Cdd:cd17325 159 LALLALVLALLLLPEPR--PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 247 VGVSLAVFGLTHALFQGLaAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACG-GITLPALQGIISV 325
Cdd:cd17325 237 IGLLFGAQGLASALSQPP-AGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGlGLVFPATLALLAD 315
|
330 340 350
....*....|....*....|....*....|....*
gi 516391490 326 RVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSA 360
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-347 |
5.71e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 126.63 E-value: 5.71e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 3 RTVMMALVIIFLDAMGIGIIMPVLPALLREFVGKANVAenyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGAT 82
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA---GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 83 LDYALMATASVVWVLYLGRLIAGI-TGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAP 160
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLlADLFGWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 161 FMFAAAINGLAFLVSLFILHETHNANQVSDelknetinetTSSIREMIS--PLSGLLVVFFIIQLIGQIPATLWVLFGEE 238
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLPESRPAARARL----------RGSLRELLRrpRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 239 RFAWDGVMVGVSLAVFGLTHALFQgLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACG-GITLP 317
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFP 315
|
330 340 350
....*....|....*....|....*....|
gi 516391490 318 ALQGIISVRVGQVAQGQLQGVLTSLTHLTG 347
Cdd:COG2814 316 LLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
10-386 |
8.11e-33 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 126.95 E-value: 8.11e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 10 VIIFLDAMGIGIIMPVLPALLREFVGKANVaenYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMA 89
Cdd:cd17331 7 LNIVLYATCYWLQQPVLPYLTKKLGVDSVV---FGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 90 TASVVWVLYLGRLIAgITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAPFMFAAAIN 168
Cdd:cd17331 84 FASSVPMLFLSRLPS-VFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLlTKKFGEQAAALVAAVGS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 169 GLAFLVSLFIL-----HETHNANQVSDELKNETINETTSSIreMISPLSGLLVVFFIIQL--IGQIPATLwVLFGEERFA 241
Cdd:cd17331 163 LLSIVLVILLIpsntkSKREKEAKESASPPSVFNLKEILRL--LRLPGVAFLLLVKLLSGlpIGMFQSMF-SLVAMDFFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 242 WDGVMVGVSLAVFGLTHALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACGGITL-PALQ 320
Cdd:cd17331 240 LTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLyTVIT 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516391490 321 GIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATretwnGW--VWIIGCGLYVVALIILRF 386
Cdd:cd17331 320 SLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAY-----GFpsFGLLGAAINGLLTVYLLL 382
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
8-384 |
1.76e-32 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 126.00 E-value: 1.76e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 8 ALVIIFLDAMGIGIIMPVLPALLREFVGkanVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYAL 87
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGL---SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 88 MATASVVWVLYLGRLIAGITGATGAVAAST-IADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF---AGQLSVQAPFMF 163
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLAlIADLFPERERGRALGLLQAFGSVGGILGPLLGGIlasSLGFGWRAVFLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 164 AAAINGLAFLVSLFILHETHNANQVSDELKNETINETTSSIREMISPLSGLLVVFFIIQLIGQIPATLWVLFGEERFAWD 243
Cdd:cd06174 158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 244 GVMVGVSLAVFGLTHALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACG-GITLPALQGI 322
Cdd:cd06174 238 VAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGlGGLLPLSFAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516391490 323 ISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATreTWNGWVWIIGCGLYVVALIIL 384
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT--FGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
10-359 |
3.63e-31 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 121.56 E-value: 3.63e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 10 VIIFLDAMGIGIIMPVLPALLREFVGKANVAenyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMA 89
Cdd:cd17390 3 LVGFLDLFGVSMILPLLSTHIRSLGASPTVI---GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 90 TASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSvqAPFMFAAAING 169
Cdd:cd17390 80 FSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETD--GGFYYVALLCS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 170 LAFLVSLFILHEthnanqvsdelknetinettssireMISPLSGLLVVFFIIQLIGQIPATLWVLFGEERFAWDGVMVGV 249
Cdd:cd17390 158 AIFILNAGLVWF-------------------------LLSKLWDLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGY 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 250 SLAVFGLTHALFQGLAAGF--IAKHLGERKAIAVGILAdGCGLFLLAVITQSWMVWPVLLLLA-CGGITLPALQGIISVR 326
Cdd:cd17390 213 LISYSGVLGALSGFLVGRIlkLYKNNEYLLLLHSFILL-ALSLLGLALAPSIWLLVLCLTPLSiSSAVLRTCSTSLLLSR 291
|
330 340 350
....*....|....*....|....*....|...
gi 516391490 327 VGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYS 359
Cdd:cd17390 292 GKSKERGTLLGVGQSVTSLARILAPLLSGLLQE 324
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
13-387 |
6.21e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 110.35 E-value: 6.21e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 13 FLDAMGIGIIMPVLPALLREF-VGKANVaenyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATA 91
Cdd:cd17474 9 LLAVLGVSIVDPILPAIAEALgASPAQV----GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 92 SVVWVLYLGRLIAGI-TGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQAPFMFAAAINGL 170
Cdd:cd17474 85 DSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 171 AFLVSLFILHETHNANQVSDELKNETINETTSSIREMISPLSGLLVVFFIIQLIGQIPATLwvlfgEERFAWDGVMVGVS 250
Cdd:cd17474 165 AFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLL-----ELLYGISPIIIGLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 251 LAVFGLTHALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLL-ACGGITLPALQGIISVRVGQ 329
Cdd:cd17474 240 FAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFgLGLGLNLPLLTTLVTELAPE 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 516391490 330 VAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETwngWVWIIGCGLYVVALIILRFF 387
Cdd:cd17474 320 EERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLS---APFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
9-388 |
1.11e-26 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 109.61 E-value: 1.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 9 LVIIFLDAMGIGIIMPVLPALLREFVGKANVAenyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALM 88
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVA---GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 89 ATASVVWVLYLGRLIAGITGATGAVAASTI-ADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAPFMFAAA 166
Cdd:cd17489 79 LLATSVALLLVLRLIHGIGWGAFTTAAATLvADIIPPSRRGEGIGYYGLATTLAMALGPALGLFlYQHLGFAVLFIVAAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 167 INGLAFLVSLFIlhetHNANQVSDELKNETINETTSSIREMISPLSGLLVVFFIIQliGQIpATLWVLFGEERFAWDGvm 246
Cdd:cd17489 159 LALLALLLVFLV----KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAY--GAI-STFLPLYAAERGISNA-- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 247 vGVSLAVFGLThALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACG-GITLPALQGIISV 325
Cdd:cd17489 230 -GLFFTVYAIA-LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVD 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516391490 326 RVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATREtwnGWVWIIGCGLYVVALIILRFFH 388
Cdd:cd17489 308 LVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGY---RAMFLLAAVVVLLALVLYIFLL 367
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
44-182 |
2.77e-25 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 100.03 E-value: 2.77e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 44 GVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLGRLIAGITGATGAVA-ASTIADVT 122
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAgAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516391490 123 PEESRTHWFGMMGACFGGGMIAGPVIGGFAGQ-LSVQAPFMFAAAINGLAFLVSLFILHET 182
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQfLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-351 |
1.10e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.96 E-value: 1.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 9 LVIIFLDAMGIGIIMPVLPALLREFVGKANVAenYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALM 88
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTE--IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 89 ATASVVWVLYLGRLIAGITGATGAVAAST-IADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAPFMFAAA 166
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALAlIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLlASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 167 INGLAFLVSLFILHETHNANQVSDELKNETINETTSSIRemISPLSGLLVVFFIIQLIGQIpATLWVLFGEERFAWDGVM 246
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALL--RDPVLWLLLALLLFGFAFFG-LLTYLPLYQEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 247 VGVSLAVFGLThALFQGLAAGFIAKHLGERKAIAVGILA---DGCGLFLLAVITQSWMVWPVLLLLACG-GITLPALQGI 322
Cdd:pfam07690 237 AGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLlilAALGLLLLSLTLSSLWLLLALLLLGFGfGLVFPALNAL 315
|
330 340
....*....|....*....|....*....
gi 516391490 323 ISVRVGQVAQGQLQGVLTSLTHLTGVIGP 351
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
9-385 |
7.74e-23 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 98.84 E-value: 7.74e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 9 LVIIFLDAMGIGIIMPVLPALLREFVGKANVAenYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALM 88
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASI--VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 89 ATASVVWVLYLGRLIAGITGATGAVAAST-IADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQAPFMFAAAI 167
Cdd:cd17329 83 GFAHSPWLFAIALVLTGFGGGLFEPASEAmIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 168 NGLAFLVSLFILHETHNanqvsdELKNETINETTSSIREMIS--PLSGLLVVFFIIQLIGQIPATLWVLFGEERFAWDGV 245
Cdd:cd17329 163 FLLAALVLLFLLPETRP------KRRAAEKTEILRGYKIVLRdrAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 246 MVGVSLAVFGLTHALFQGLAAGFIaKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACGG-ITLPALQGIIS 324
Cdd:cd17329 237 LLGLLLALNALLIVLLQFPVARLV-ERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEmLVFPAVQTLVA 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516391490 325 VRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETWNGWVWIIGCGLYVVALIILR 385
Cdd:cd17329 316 ALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
9-357 |
1.30e-20 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 92.25 E-value: 1.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 9 LVIIFLDAMGIGIIMPVLPALLREFVGkaNVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVlllsLLGATLDYALM 88
Cdd:cd17473 5 LLASTLTVMAGAAIAPALPAIAQHFVP--NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRL----LIAGLLLYGIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 89 ATASVV----WVLYLGRLIAGI-TGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQAPFmf 163
Cdd:cd17473 79 GVAGLFldslYALLASRALLGIgVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPF-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 164 aaAINGLAFLVSLFILHETHNANQVSDELKNETINETTSSIREMISPLSGLL----VVFFIIQLigQIPATLwvlfgEER 239
Cdd:cd17473 157 --LVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAflamLLFYVIPI--QLPFLL-----QER 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 240 FAWDGVMVGVSLAVFGLTHALfQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACG-GITLPA 318
Cdd:cd17473 228 GGGSAALIGLALAIASLAGAI-GALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGfGLLLPT 306
|
330 340 350
....*....|....*....|....*....|....*....
gi 516391490 319 LQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFL 357
Cdd:cd17473 307 LNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPL 345
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
11-384 |
4.13e-20 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 90.80 E-value: 4.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 11 IIFLDAMGIGIIMPVLpallREFVGKANVAENYGVLLALYAMmqvIFAPLLGRWSDRIGRRPVLLLSLLGATLDY----- 85
Cdd:cd17386 7 IVFLYMFASVLSGPVT----QNFVYAANFYLYMNLMGSIPPL---FSSLFLGSWSDRYGRKPPLLMSLVGLLLSSlilvl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 86 -ALMATASVVWVLYLGRLIAGITGATGAVAAST---IADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFA-GQLSVQAP 160
Cdd:cd17386 80 iVYFTTVPSVWWFYLSAIPLALFGGFTAFLSASfayISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLfKALGYAWS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 161 FMFAAAINGLAFLVSLFILhethnanqvsdelknetinettssireMISPLSGLLVVFFIIQLIGQipATLWVLFGEERF 240
Cdd:cd17386 160 FSISAALLLIALLYILFFL---------------------------TLLILLLLAAFLTIFVLSGE--SDVLYLFVLEKF 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 241 AWDGVMVGVSLAVFGLTHALFQGLAAGFIAKHLGERKA--IAVGILADGCGLFLLAVITQSWMVWPVLLLLACGGITLPA 318
Cdd:cd17386 211 AWNVKDFSYFSTLGSLIYLTGMLGGVLLLRCLLKMSDStlAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPM 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516391490 319 LQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETWNGWVWIIGCGLYVVALIIL 384
Cdd:cd17386 291 IRSILSKLVPKSEQGKIFSLLSVLESLSPLVASPIYNNIYKATLTTFPGFFFLLSAGLLLIPVILI 356
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
13-387 |
8.65e-20 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 90.02 E-value: 8.65e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 13 FLDAMGIGIIMPVLPALLREF--VGKANVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMAT 90
Cdd:cd17391 6 FFTGIGFSLIAPFLPLYIEQLgvTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 91 ASVVWVLYLGRLIAGITgaTGAVAAST--IADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAPFMFAAAI 167
Cdd:cd17391 86 VTNVWQLLILRLLQGVF--SGYVPNATalIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFlADLFGIRNVFFITGGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 168 NGLAFLVSLFILHETHNANQVSDELKNETINETTSSIREMISplsgLLVVFFIIQLIGQIPATLWVLFGEERFAWDGVMV 247
Cdd:cd17391 164 LFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLIS----LFVTTFIIQLANQSIEPILTLYIRQLMGDASNLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 248 GVSLAVFGLThALFQGLAAGFIAK---HLGERKAIAVGILADGCGLFLLAVITQSW--MVWPVLLLLACGGItLPALQGI 322
Cdd:cd17391 240 FISGLVFSAT-GVSSLLSAPRLGKlgdRIGHHRILLGALLASALLYIPQAFVQTPWqlGILRFLLGLATGGL-LPAINSL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516391490 323 ISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFL--YSATRetwngWVWIIGCGLYVVALIILRFF 387
Cdd:cd17391 318 LAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIaaHFGYR-----AVFVVTALLVLLNAIWSFIF 379
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
10-358 |
1.41e-19 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 89.64 E-value: 1.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 10 VIIFLDAMGIGIIMPVLPALL----------------------REFVG-----KANVAENYGVLLALYAMMQVIFAPLLG 62
Cdd:cd17389 6 LALLLDLLAFTIILPLFPSLLdyygqnddsglyslqissvdwfRDAIGapderRYNSVLFGGLIGSLFSLLQFLSSPITG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 63 RWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGM 142
Cdd:cd17389 86 AASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 143 IAGPVIGG-FAGQ-LSVQAPFMFAAAINGLAFLVSLFILhethnanqVSDELKnETINETTSSIRemisplsglLVVFFI 220
Cdd:cd17389 166 IIGPMIGAyFASFtRSLGEVFFSMPALFALVLALADLLF--------IFFFLP-ETLPSNLRRLG---------LVYFLY 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 221 IQLIGQIPATLWVLFgEERFAWDGVMVGVSLAVFGLTHALFQGLAAGFIaKHLGERKAIAVGILADGCGLFLLAVITQSW 300
Cdd:cd17389 228 LFLFSGLEFTLTFLT-HQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRI-KPGKEKKAVLQGLILLIPAFLLIGWASSVT 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 516391490 301 MVWPVLLLLACG-GITLPALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLY 358
Cdd:cd17389 306 VLYAGLFLYSFAaATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVY 364
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-387 |
8.39e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 84.16 E-value: 8.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 7 MALVIIFLDAMGIGIIMPVLPALLrefvgKANVAEnYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYA 86
Cdd:COG2223 12 LAFFLAFGVWYLWSVLAPPLAEEF-----GLSAAQ-LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 87 LMATASVVWVLYLGRLIAGITGATG-AVAASTIADVTPEESRTHWFGMMGACFG-GGMIAGPVIGGFAGQLSVQAPFMFA 164
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNlGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 165 AAINGLAFLVSLFILHEThnanqvsDELKNETINETTSSIREMI-SPLSGLLVVFFIIQLIGQIPATLW-VLFGEERFAW 242
Cdd:COG2223 166 GILLLVVAVLAWLFLRDP-------PAGAAAAAKASLRDQLEALrDPRFWLLSLLYFGTFGSFIGFSSWlPPYLVDQFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 243 DGVMVGVSLAVFGLTHALFqGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSW--MVWPVLLLLACGGITLPALQ 320
Cdd:COG2223 239 SAATAGLLAALFALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLwlFLVLFLLLGLALGGGNGAVF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516391490 321 GIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATrETWNgWVWIIGCGLYVVALIILRFF 387
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT-GSYT-AAFLVFAVLALVALVLTLLL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-179 |
2.28e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.01 E-value: 2.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 1 MNRTVMMALVIIFLDAMGIGIIMPVLPALLREfVGKANVAEnYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLG 80
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAE-LGGLSPAQ-IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 81 ATLDYALMATASVVWVLYLGRLIAGITGATGAVAAST-IADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQ 158
Cdd:cd17325 275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAlLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFlYDAFGFA 354
|
170 180
....*....|....*....|.
gi 516391490 159 APFMFAAAINGLAFLVSLFIL 179
Cdd:cd17325 355 TPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
5-385 |
1.33e-16 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 80.70 E-value: 1.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 5 VMMALVIIFLDAMGIGIIMPVLPALLREFVGKANVAEN-YGVLLALYAMMQVIFAPLlgrwSDRIGRRPVLLLSLLGATL 83
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLtLSAYLLGFALGQLLYGPL----SDRFGRRPVLLAGLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 84 DYALMATASVVWVLYLGRLIAGITGATGAVAA-STIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAPF 161
Cdd:cd17320 77 ASLLCALASSIEQLLIARFLQGLGAAAGSVVArAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLlLLFFGWRAIF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 162 MFAAAINGLAFLVSLFILHETHNANQVSDELKnetinettSSIREMISPLSGLLVVFFIIqLIGQIPATLWVLFGEERFa 241
Cdd:cd17320 157 VFLALLGLLLLLLVLLFLPETLPEEKRKPLLS--------SLLRAYKRVLKNRRFLGYAL-ALGLSFAGLFAYLAAAPF- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 242 WDGVMVGVSLAVFGLTHAL------FQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQS------WMVWPVLLLL 309
Cdd:cd17320 227 IYIEQLGLSPAQFGLLFALnaialiLGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLgglslwPLVAPLFLIF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516391490 310 ACGGITLPALQGIISVRVGQVAqGQLQGVLTSLTHLTGVIGPLVFAFLYSATreTWNGWVWIIGCGLYVVALIILR 385
Cdd:cd17320 307 FGFGLIFPNATSLALEPFPHVA-GTASALLGFLQFLIGALAGALVGLLPNGT--ALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
9-323 |
1.48e-16 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 80.34 E-value: 1.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 9 LVIIFLDAMGIGIIMPVLPALLREFVGKANVAenyGVLLALYAMMQVIFAPLLGRWSDRIGRR-PVLLLSLLGATLDYAL 87
Cdd:cd17490 2 LIIVFLFWFSQYVYVPFLSPYAESLGASLSMI---GIILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 88 MATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAPFMFAAA 166
Cdd:cd17490 79 MILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLiAEHFGMRAPFLLAAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 167 INGLAFLVSLFILHETHNANQVSDELKNetinettssIREMISplSGLLVVFFIIQLIGQI-----PATLWVLFGEERFA 241
Cdd:cd17490 159 AGVLGFILSLFIKEERREKKPVLTELKE---------LLSVLK--DKKLLFFSLLAILQQMitfstTFGFTPLIAKQLGA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 242 wDGVMVGVSLAVFGLTHALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACG-GITLPALQ 320
Cdd:cd17490 228 -SSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGtGILFPLLM 306
|
...
gi 516391490 321 GII 323
Cdd:cd17490 307 SLS 309
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-389 |
5.06e-16 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 78.76 E-value: 5.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 3 RTVMMALVIIFLDAMGIGIIMPVLPALLREFvgKANVAEnYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGAT 82
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADL--GLSAAQ-LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 83 LDYALMATASVVWVLYLGRLIAGI-TGATGAVAASTIADVTPEESRTHWFGMMGACFG-GGMIAGPVIGGFAGQLSVQAP 160
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPlGGALAPPLLGWLLAAFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 161 FMFAAAINGLAFLVSLFIlhethnanqvsdelknetinettssiremisplsgLLVVFFIIQLIGQIPATLWVLFGEERF 240
Cdd:COG2271 167 FLILGLPGLLLALLRFWL-----------------------------------LALAYFLVYFALYGFLTWLPTYLVEVR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 241 AWDGVMVGVSLAVFGLThALFQGLAAGFIAKHLGERKAIAVGILAdGCGLFLLAVITQSWMVWPVLLLLACGGITLPALQ 320
Cdd:COG2271 212 GLSLAQAGLLLSLPFLA-GIVGSLLGGWLSDRLGRRRKLVLAIGL-LLAALALLLLALLPSPALAIALLFLAGFGLGGAF 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 321 GIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETWN-GWVWIIGCGLYVVALIILRFFHP 389
Cdd:COG2271 290 GLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGyQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
21-383 |
1.32e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 77.59 E-value: 1.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 21 IIMPVLPALLREFVGKANVAenyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLG 100
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQA---GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 101 RLIAGIT-GATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQ-LSVQAPFMFAAAINGLAFLVSLFI 178
Cdd:cd17324 94 RALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQlLGWRAAFLAIAVLALLAALLLWRL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 179 L-HETHNANQVSDELKNETinettsSIREMISPLSGLLVVFFIIQLIGQIPATLwVLFGEERFAWDGVMVGVSLAVFGLT 257
Cdd:cd17324 174 LpSLPPKKPGSLGLLSSLL------LLLRNPRLRLAYLITFLLFGGFFALYTYL-APFLTDVPGFSSSAIIGLLLLFGVA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 258 hALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACG-GITLPALQGIISvRVGQVAQGQLQ 336
Cdd:cd17324 247 -GVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGfFAAHSALQTRVL-RLAPEARGLAS 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 516391490 337 GVLTSLTHLTGVIGPLVFAFLYSATreTWNGWVWIIGcGLYVVALII 383
Cdd:cd17324 325 SLYLAAYNLGGALGAALGGLVLDHG--GWAGVGWVGA-ALLLLALLL 368
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
10-387 |
2.29e-15 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 76.86 E-value: 2.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 10 VIIFLDAMGIGIIMPVLPALLREFVGKANvAENYGVLLALYAMMQVIFAPLLGRWSDRIG--RRP--VLLLSLLGATLDY 85
Cdd:cd17326 6 LTMFLSSLQFSIVLTSIWPYLQKIDPTAT-ASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsvKEPliVSILIAIVGNILY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 86 AL--MATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQ----- 158
Cdd:cd17326 85 ALaeYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPgyvig 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 159 ---------APFMFAAAINGLAFLVSLFILHEThnanqvsdelknetinettssiremisplsGLLVVFFIIQLIGQIPA 229
Cdd:cd17326 165 iklrfnmytAPAWLMAILGIINIILILFFFKEV------------------------------VCIFLFFVVLFIFANLE 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 230 TLWVLFGEERFAWDG----VMVGVSLAVFGLTHALFQGLAAGFIAKHLGERKAIAVGILADGCGLfllaVITQSWMVWPV 305
Cdd:cd17326 215 TIGTPLTMDMYGWTReeavLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGF----VVTLPWGITGV 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 306 LLLLACGGITLPALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETwngWVWIIGCGLYVVALIILR 385
Cdd:cd17326 291 ILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPR---WTWIITLGLLLLAIILLI 367
|
..
gi 516391490 386 FF 387
Cdd:cd17326 368 VF 369
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
8-381 |
1.93e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 74.13 E-value: 1.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 8 ALVIIFLDAMGIGIIMPVLPALLREFVGKANVAenyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYAL 87
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALI---GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 88 MATASVVWVLYLGRLIAGITGATGAVAAST-IADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSvQAPFMFAAA 166
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIGLAGLFVVSESwLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG-ALPFLIAAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 167 INGLAFLVSLFILHETHnanqvsdelknETINETTSSIREMISPLSGLLVVFFIIQLIGQIPATLWVLFGeERFAWDGVM 246
Cdd:cd17477 157 LLLLALVPLLLTRRAAP-----------EIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYG-LRLGLSVAQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 247 VGVSLAVFGLTHALFQgLAAGFIAKHLGERKAIAV-GILADGCGLFLLAVITQSWMVWPVLLLLacgGITLPALQGIISV 325
Cdd:cd17477 225 AALLLAAFVLGGLLLQ-WPLGWLADRFDRRRVLLGcALLGALAALLLPLVPGLPLALLVLLFLW---GGAAGPLYTLALA 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 326 RVGQVAQG----QLQGVLTSLTHLTGVIGPLVFAFLYSATRETWNGWVWIIGCGLYVVAL 381
Cdd:cd17477 301 LAGDRLPGdelvAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
12-360 |
3.85e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 73.36 E-value: 3.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 12 IFLDAMGIGIIMPVLPALLREFvgKANVAENYGVLLAlYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATA 91
Cdd:cd17321 5 VFLAALDVTIVNVALPTIARDL--GASPSQLQWVVNA-YLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 92 SVVWVLYLGRLIAGITGA-TGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAPFMFAAAING 169
Cdd:cd17321 82 PSLAFLIAARALQGIGAAaIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLlLELFGWRWIFLINVPIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 170 LAFLvslfilhethnanqvsdelknetinettssireMISPLSGLLVVFFIIQLIGQIPATLWVLFGEERFAWDGVMVGV 249
Cdd:cd17321 162 VALL---------------------------------LARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 250 SLAVFGLTHALFqGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACGGI----TLPALQGIISV 325
Cdd:cd17321 209 ALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLglglFATPLTNAALS 287
|
330 340 350
....*....|....*....|....*....|....*
gi 516391490 326 RVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSA 360
Cdd:cd17321 288 SVPKEKAGAASGILNTARQLGGALGVALLGALLTA 322
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
10-198 |
1.19e-13 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 71.86 E-value: 1.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 10 VIIFLDAMGIGIIMPVLPALLREFVGkaNVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMA 89
Cdd:cd17472 3 LIFSLRMLGMFLVLPVLSVYAKSLPG--ATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 90 TASVVWVLYLGRLIAGItGATGAVAASTIADVTPEESRTHWFGMMGACFG----GGMIAGPVIGGFagqLSVQAPFMFAA 165
Cdd:cd17472 81 YATSIYGLILGRALQGS-GAISSVVMALLADLTREENRTKAMALIGASIGiafaISMVLGPLLAAH---LGVSGLFLITA 156
|
170 180 190
....*....|....*....|....*....|...
gi 516391490 166 AINGLAFLVSLFILHETHNANQVSDELKNETIN 198
Cdd:cd17472 157 ILSLVSLLILLFFVPDPPKIVQISEKEKKKLKK 189
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-384 |
2.18e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 71.04 E-value: 2.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 1 MNRTVMMALVIIFLDAMGIGIIMPVLPALLREFvgKANVAENYGVLLALYAMmQVIFAPLLGRWSDRIGRRPVLLLSLLG 80
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAF--GLSDAQAGLLLFAFFLG-YLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 81 ATLDYALMATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQAP 160
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 161 FMFAAAINGLAFLVSLFILHETHNANQVSDELKNETINETTSSIREMISPLSGLLVVFFIIqLIGQIPATLWVLFGEERF 240
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYV-GAEGAIGDWLPLYLKDVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 241 AWDGVMVGVSLAVFGLTHALFQgLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACG-GITLPAL 319
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGR-FLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGlSLMFPTI 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516391490 320 QGIISVRVGQVAQGQLQGVLTSLThLTGVIGPLVFAFLYSATrETWNGWVWIIGCGLYVVALIIL 384
Cdd:COG0738 321 FSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLLILLLALA 383
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-285 |
1.11e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 67.91 E-value: 1.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 3 RTVMMALVIIFLDAMGIGIIMPVLPALLREFvgKANVAEnYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGAT 82
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADL--GASSAQ-LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 83 LDYALMATASVVWVLYLGRLIAGITGATGAVAAST-IADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAP 160
Cdd:COG0477 91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALAlIAELFPARERGRALGLWGAAIGLGLALGPLLGGLlVAALGWRWI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 161 FMFAAAINGLAFLVSLFILHETHNANQVSDELKNETINETTSSIREMISPLSGLLVVFFIIQLIGQIPATLWVLFGEERF 240
Cdd:COG0477 171 FLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLAL 250
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 516391490 241 AWDGVMVGVSLAVFGLTHALFQGLAAGFIAKHLGERKAIAVGILA 285
Cdd:COG0477 251 LLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
5-358 |
1.46e-12 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 68.60 E-value: 1.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 5 VMMALVIIFLDAMGIGII-MPVLpALLREFVGKANVAENyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATL 83
Cdd:cd17387 1 VYHAVVVIFLEFFAWGLLtTPMI-TVLHETFPQHTFLMN-GLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 84 DYALMATASvvWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQAPFMF 163
Cdd:cd17387 79 PIPLMRISP--WWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 164 AAAINGLA-FLVSLFILHETHNANQVSDELKNETINETT---SSIREMISPLSGLL--VVFFIIQLIGQIPATLWVLFGE 237
Cdd:cd17387 157 VATIVALLdICFILLAVPESLPEKMRPASWGAPISWEQAdpfASLRKVGKDKTVLLicITVFLSYLPEAGQYSSFFVYLK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 238 ERFAWDGVMVGVSLAVFGLTHALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACGGITLP 317
Cdd:cd17387 237 QVMGFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFP 316
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 516391490 318 ALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLY 358
Cdd:cd17387 317 AISALVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVF 357
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
3-387 |
2.81e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 67.59 E-value: 2.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 3 RTVMMALVIIFLDA---MGIGIIMPVLPALLREFVGKANVAenyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLL 79
Cdd:COG2807 15 GRWLLLLAIVLVALnlrPAITSVGPLLPEIRADLGLSATQA---GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 80 GATLDYALMATASVVWVLYLGRLIAGITGATGAVAASTIAdvtpeesrTHWFG-----MMGACF----GGGMIAGPVIGG 150
Cdd:COG2807 92 LLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLI--------KRWFPdrvglMTGLYTaamgLGAALAAGLTVP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 151 FAGQLSVQAPFMFAAAINGLAFLVSLFILHETHNANQVSDelknetinETTSSIREMISPLSGLLVVFFIIQLIGQIPAT 230
Cdd:COG2807 164 LAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAP--------AAASLRSLWRSPLAWLLTLFFGLQSLLYYAVV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 231 LW-VLFGEERfAWDGVMVGVSLAVFGLTHALFqGLAAGFIAKHLGERKAIAVGILADGC-GLFLLAVITQSWMVWPVLLL 308
Cdd:COG2807 236 AWlPPILRDA-GLSAATAGLLLSLFQLAGIPG-SLLVPLLADRLGDRRPLLLLLGLLGLaGLLGLLLAPGSLPWLWAVLL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 309 LACGGITLPALQGIISVRVGQVAQ-GQLQGVLTSLTHLTGVIGPLVFAFLYSATrETWNgWVWIIGCGLYVVALIILRFF 387
Cdd:COG2807 314 GLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDAT-GSWT-AALLLLAALAVLMLVAGLLA 391
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
44-386 |
3.55e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 67.26 E-value: 3.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 44 GVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLG-----ATLDYALMATASVVWVLYLGRLIAGITGATGAVAA-ST 117
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLrallaAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 118 IADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFagqLSVQAPFMFAAAINGLAFLVS---LFILHETHNANQVSDELKN 194
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGL---LVALLGPGGAFAINALSFLLSallLLFIRRPPPAAPGESSSLL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 195 ETINETTSSIREMISPLSGLLVVFFIIQLIGQIPATLWVLFGEERFAWDGVMVGVSLAVFGLThALFQGLAAGFIAKHLG 274
Cdd:cd06173 194 LRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVG-ALLGALLLGRLSKRRR 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 275 ERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLL-ACGGITLPALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLV 353
Cdd:cd06173 273 RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLgLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
330 340 350
....*....|....*....|....*....|...
gi 516391490 354 FAFLysATRETWNGWVWIIGCGLYVVALIILRF 386
Cdd:cd06173 353 AGLL--ADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-404 |
4.09e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.23 E-value: 4.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 13 FLDAMGIGIIMPVLPALLREFVGKANVAenYGVLLALYAMMQVIFAPLLGRWSDRIG-----RRPVLLLSLLGATLDYAL 87
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVLGLSAAL--VGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 88 MATA------SVVWVLYLGRLIAGITGATGAVAAST-IADVTPE-ESRTHWFGMMGACFGGGMIAGPVIGGFA------- 152
Cdd:COG2211 98 LFTApdlsptGKLIYALVTYLLLGLAYTLVNIPYSAlGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLvaafggd 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 153 GQLSVQAPFMFAAAINGLAFLVSLFILHETHNANQVSDELKnetinettSSIREMIS--PLSGLLVVFFIIQLIGQIPAT 230
Cdd:COG2211 178 AALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLK--------ESLKALLKnrPFLLLLLAYLLFFLALALVAA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 231 LWVLFGEERFAWDGVMVGVSLAVFGLTHALFQgLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWmVWPVLLLLA 310
Cdd:COG2211 250 LLLYYFKYVLGLSAALVGLLLALYFLAALLGA-PLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN-LWLLLVLAA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 311 CGGITLPALQGIISV-----------RVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSA------------TRETWNG 367
Cdd:COG2211 328 LAGIGLGAILVLPWAmladvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALfgyvagaaqspsALTGIRL 407
|
410 420 430
....*....|....*....|....*....|....*..
gi 516391490 368 WVWIIGCGLYVVALIILRFFHPGRVIHPINKSDVQQR 404
Cdd:COG2211 408 LFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAAR 444
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
9-383 |
9.50e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 66.06 E-value: 9.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 9 LVIIFLDAMGIGIIMPVLPALLREFVGKANVAenyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALM 88
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAV---SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 89 ATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAPFMFAAAI 167
Cdd:cd17504 79 AFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWiVQHLGWRWIFWTAAPV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 168 NGLAFLVSLFIlhethnanqvsdELKNETINETTSSIREMISPLSGLLVVFFIIQLIGQIPATLWVLFGEERFAWdgVMV 247
Cdd:cd17504 159 AVLLAALVPLI------------DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGL--LLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 248 GVSLAvfglthALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQS-WMVWPVLLLLACG-GITLPALQGIISV 325
Cdd:cd17504 225 PGALV------MLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSlWALVVALLLIGIGlGLAFASLPNIVVE 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516391490 326 RVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETWNGWV----------WIIGCGLYVVALII 383
Cdd:cd17504 299 SVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGvptegayvlaFLIGAALALAALLL 366
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
9-383 |
2.68e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 64.12 E-value: 2.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 9 LVIIFLDAMGIGIIMPVLPALLREFvgkaNVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALM 88
Cdd:cd17502 2 MLALFLAALDQTIVATALPTIVAEF----GGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 89 ATASVVWVLYLGRLIAGITGAT-GAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGG-FAGQLSVQAPFMFAAA 166
Cdd:cd17502 78 GLAPNMTMLIVGRAIQGIGGGGlMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGaFTDHLSWRWCFYINLP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 167 INGLAFLVSLFILhethnanqvsdelknetinettssiremISPLSGLLVVFFIIQLIGQIPatlwvLFGEERFAWDGVM 246
Cdd:cd17502 158 IGGLALALLRTIL----------------------------LSSIFGFLFGGALFGLIYYLP-----LYFQLVLGDSATK 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 247 VGVSLAVFGLTHALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACGGITLPALQGIISVR 326
Cdd:cd17502 205 SGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVA 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 516391490 327 VGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLysatretwnGWVWIIGCGLYVVALII 383
Cdd:cd17502 285 VQNAVPPADVGVATATNTFFRSLGGTLGVAI---------TDVFLVALALAALAFLL 332
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
13-179 |
4.86e-11 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 63.75 E-value: 4.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 13 FLDAMGIGIIMPVLPALLREF-VGKANVAENYGVLLALYAMMQVIFAPLlgrwSDRIGRRPVLLLSLLGATLDYALMATA 91
Cdd:cd17323 9 FVVTFGSSIYSPALPQIAEDFhVSEEVANLGVSLFVLGFGLGPLIWAPL----SELYGRRPVYLVSLFIFVIFQIGCALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 92 SVVWVLYLGRLIAGITGATG-AVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQ-LSVQAPFMFAAAING 169
Cdd:cd17323 85 PNIAMLIILRFLQGFFGSSPlAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQsLGWRWIFWFLAIISG 164
|
170
....*....|
gi 516391490 170 LAFLVSLFIL 179
Cdd:cd17323 165 FCLILIFLFL 174
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
3-355 |
1.49e-10 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 62.24 E-value: 1.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 3 RTVMMALVIIFLDAMGIGIIMPVLPALLREFVGKANVAENY--GVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLG 80
Cdd:PRK09874 14 RNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 81 ATLDYALMATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQA 159
Cdd:PRK09874 94 MGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLlADSYGLRP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 160 PFMFAAAINGLAFLVSLFILHEthNANQVSdelKNETInettsSIREMISPLSG--LLVVFFIIQLIGQIPA-------T 230
Cdd:PRK09874 174 VFFITASVLFLCFLVTLFCIRE--NFQPVS---KKEML-----HMREVVTSLKNpkLVLSLFVTTLIIQVATgsiapilT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 231 LWVLFGEERFAWDGVMVGVSLAVFGLThALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLL- 309
Cdd:PRK09874 244 LYVRELAGNVSNIAFISGMIASVPGVA-ALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLg 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 516391490 310 ACGGITLPALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFA 355
Cdd:PRK09874 323 AADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGA 368
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
45-174 |
2.29e-10 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 61.79 E-value: 2.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 45 VLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLGRLIAGI-TGATGAVAASTIADVTP 123
Cdd:cd17370 238 LLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLyMGAQESIERAAVADLVP 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 516391490 124 EESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAPFMFAAAINGLAFLV 174
Cdd:cd17370 318 AELRGTAYGLFNTVVGIGWLLASLIAGYlWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
1-177 |
8.09e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.92 E-value: 8.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 1 MNRTVMMALVIIFLDAMGIGIIMPVLPALLREfvgkaNVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLG 80
Cdd:cd17489 192 VEKKVLPPALILFLASIAYGAISTFLPLYAAE-----RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 81 ATLDYALMATASVVWVLYLGRLIAGITGATGAVAASTIA-DVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQ 158
Cdd:cd17489 267 LALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAvDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLvAELFGYR 346
|
170
....*....|....*....
gi 516391490 159 APFMFAAAINGLAFLVSLF 177
Cdd:cd17489 347 AMFLLAAVVVLLALVLYIF 365
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
44-384 |
8.12e-10 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 60.21 E-value: 8.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 44 GVLLALYAMMqvifapLLGRWSDRIGRRPVLLLSLLGATLDYAL----MATASVVWVLYLGRLIAGITGATGAVAA---S 116
Cdd:cd17449 74 GFLVGLFSVT------LLGPWSDSVGRRPVLILPSLGLALQAAVyllvMYLQLHVAYFLIGRILSGLLGDFNGILAgcfA 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 117 TIADVTPEESRTHWFGMMGACFG-GGMIAGPVIGGFAGQLSVQAPFMFAAAINGLAFLVSLFILHETHNANQVSdelKNE 195
Cdd:cd17449 148 YVADVSDRRSRTFRVAVLEACLGlAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKEPKSA---RLF 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 196 TINETTSSIREMISP--------LSGLLVVFFIIQLIGQIPATLWVLFG-EERFAWDGVMVGVSLAVFGLTHaLFQGLAA 266
Cdd:cd17449 225 TTRHHQSVVRLYVAPapngsrrkLALYSLALFVVVTVHFGAKDLLVLYElSSPLCWDSDLIGYGSAAEHLTY-LSSLLGL 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 267 GFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACGGITLPALQGIISVRVGQVAQGQLQGVLTSLTHLT 346
Cdd:cd17449 304 RLLQLCLEDTWVAEIGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEGLC 383
|
330 340 350
....*....|....*....|....*....|....*...
gi 516391490 347 GVIGPLVFAFLYSATRETWNGWVWIIGCGLYVVALIIL 384
Cdd:cd17449 384 SLVATGIFNSLYPATLHFMKGFPFLFGAALLLIPAGII 421
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
9-386 |
1.48e-09 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 59.18 E-value: 1.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 9 LVIIFLDAMGIGIIMPVLPALLREFVGKANVAEN-YGVLLALYAMMQVIFAPLLGRWSDR----IGRR-PVLLLSLLGAT 82
Cdd:cd17313 1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHAlIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRrPFILVGAPLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 83 LDYALMATASVVWVLY--LGRLIAGITGATGAV------------AASTIADVTPEESRT---HWFGMMG------ACFG 139
Cdd:cd17313 81 LGLILIPNAADIGLALgdGPRTWALVLFVLGIVlldfamnvcqgpVRALLPDLVPPEQRSkanGIINFMGglggvlGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 140 GGMIAGPVIGGFAGQLSVQAPFMFAAAINGLAFLVSLFILHETHNANQVSDELKNETINETTSSIREMISPLSGLLVVFF 219
Cdd:cd17313 161 GAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSLLRLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 220 IIQLIGQIP-------ATLWV---LFGEERFAWDGVMVGVSLAVFGLT----HALFQGLAAGFIAKHLGERKAIAVGILA 285
Cdd:cd17313 241 LVIFFWWIAffpfelfFTDYMgeeVYHGTSAASSHYGAGVRMGAWGLLifslAFLIFSLPIGKLGKKIGRKKVYLIGLVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 286 DGCGLFLLAVITQSWMvwpVLLLLACGGITLPALQGI------ISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYS 359
Cdd:cd17313 321 FAVGMALMALVHNVTV---ALVLFALGGIGWATININpyplvsDYHSESGRGQGTDTGLLNLAISLAQILVSLLAGPIID 397
|
410 420
....*....|....*....|....*..
gi 516391490 360 AtreTWNGWVWIIGCGLYVVALIILRF 386
Cdd:cd17313 398 V---KGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
9-311 |
4.38e-09 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 57.56 E-value: 4.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 9 LVIIFLDAMGIGIIMPVLPALLREFVGKANVAenYGVLLALYAMMQVIFAPLLGRWSDRIG-RRPVLLLSLLGATLDYAL 87
Cdd:cd17471 2 LLATLLTGLAGAFVLPYLSLFLTEELGASPLQ--IGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 88 MATASVVWVLylgrLIAGIT-GATGAVAASTI-------ADVTPEESRTHWFGMMGACFGGGMIAGPVIGGF-AGQLSVQ 158
Cdd:cd17471 80 FAFLRNYWVL----LLVGVVlLSLGAAAFPQLfalareyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLlLDVLGFT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 159 APFMFAAAINGLAFLVSLFILhethnANQVSDELKNETINETTSSIREMISPLSGL-LVVFFIIQLIGQIPATLWV---L 234
Cdd:cd17471 156 GLFLLAALLYLVVALLVLFLL-----PSVKPPAQKATPASSLVKAPVNRRLLLLFAaFTLLFAANSMYIIAMPLYVtneL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 235 FGEERFAwdGVMVGVSlavfglthALFQ---GLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLAC 311
Cdd:cd17471 231 GGSESWV--GLLFGLA--------AALEipiMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAI 300
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
2-177 |
6.33e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.60 E-value: 6.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 2 NRTVMMALVIIFLDAMGIGIIMPVLPALLREFVGkaNVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGA 81
Cdd:COG2211 227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLG--LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 82 TLDYALMATASV--VWVLYLGRLIAGIT-GATGAVAASTIADVTPEESRTHWFGMMGACFGG-------GMIAGPVIGGF 151
Cdd:COG2211 305 ALGLLLLFFLGPgnLWLLLVLAALAGIGlGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIftfaiklGQALAGALAGL 384
|
170 180
....*....|....*....|....*...
gi 516391490 152 AGQLS--VQAPFMFAAAINGLAFLVSLF 177
Cdd:COG2211 385 LLALFgyVAGAAQSPSALTGIRLLFFLL 412
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-142 |
1.94e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.75 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 2 NRTVMMALVIIFLDAMGIGIIMPVLPALLREFVGKAnvAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGA 81
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS--ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516391490 82 TLDYALMATASVVWVLYLGRLIAGIT-GATGAVAASTIADVTPEESRTHWFGMMGACFGGGM 142
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
4-182 |
3.04e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.88 E-value: 3.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 4 TVMMALVIIFLDAMGIGIIMPVLPALLREFVGKANVAenYGVLLALYAMMQVIFAPLLGRWSDRIGRR--PVLLLSLLGA 81
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ--AGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 82 TLDYALMATASVVWVLYLGRLIAGI-TGATGAVAASTIADVTPEESRTHWFGMMGAC-FGGGMIAGPVIGGFAGQLSVQA 159
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFgLGGAFGLLWALAAELFPKKARGTASGLVNTFgFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|...
gi 516391490 160 PFMFAAAINGLAFLVSLFILHET 182
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRET 361
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
56-387 |
7.19e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.81 E-value: 7.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 56 IFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYL--GRLIAGITGATGAVAASTIADVTPEESRTHWFGM 133
Cdd:cd17355 53 LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLlwGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 134 MGACFGGGMIAG-PVIGGFAGQLSVQAPFMFAAAINGLAFLVSLFILHETHNANQVSDELKNETINETTSSIREMISPLS 212
Cdd:cd17355 133 LTAGGGLGSLVFlPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 213 GLLVVFFIIQLIGQ--IPATLWVLFGEERFAwdGVMVGVSLAVFGLThALFQGLAAGFIAKHLGERKAIAVGILADGCGL 290
Cdd:cd17355 213 WLLALAFFLCGFAVvgLIVHLVPYLADRGIS--PAAAAVALALIGLF-NIVGRLLSGWLGDRYSPRRLLAASYALRALGL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 291 FLLAVITQSWMVWPVLLLL--ACGGITLPALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETwnGW 368
Cdd:cd17355 290 ALLLLLPFPPLALLLFAALfgLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSY--TA 367
|
330
....*....|....*....
gi 516391490 369 VWIIGCGLYVVALIILRFF 387
Cdd:cd17355 368 AWALAVALGLIAALLVLPI 386
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
5-384 |
7.79e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 53.76 E-value: 7.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 5 VMMALVIIFLDAMGIGIIMPVLPALLREFVGKANVAENYGVLLALYAMMqVIFAPLLGRWSDRIGRRPVLLLSLLGATLD 84
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGR-PIGALLFGYLGDRIGRKKALILTLLLFGLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 85 YALMATASVVWVLYLGRLIAGI-TGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQ----- 158
Cdd:cd17316 80 TLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgwr 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 159 APFMFAAAINGLAFLVSLFILhethnanqvsdelknetinettssiremisplsgLLVVFFIIQLIGQIPATLWV-LFGE 237
Cdd:cd17316 160 ILFLIGALPALLALLLRRRTL----------------------------------LLILLWFFISFGYYGLTTFLpTYLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 238 ERFAWDGVMVGVSLAVFGLThALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSwMVWPVLLLLACGGITLP 317
Cdd:cd17316 206 TVLGLSPATSSLYLLLISLG-ALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSG-SPTLLLLLLFILSFFVG 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516391490 318 ALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETWNGW--VWIIGCGLYVVALIIL 384
Cdd:cd17316 284 GVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTgvPALILALLAIVALIVA 352
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
13-384 |
8.52e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 53.70 E-value: 8.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 13 FLDAMGIGIIMPVLPALLREFvgKANVAeNYGVLLALYAMMQVIFAPLLGRWSDRIGRR-PVLLLSLLGATLDYALMATA 91
Cdd:cd17370 9 LFADISYEMARSILPLFLVVL--GASAA-AVGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLALA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 92 SVVWVLYLGRLIAGI-TGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFA---GQLSVQAPFMFAAAI 167
Cdd:cd17370 86 GSWQLVLLLRILERLgKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlylLGGNYRTIFLLAAIP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 168 NGLAFLVSLFILHETHNANQVSDELKNEtinettsSIREMISPLSGLLVVFFIIQLiGQIPATLWVLFGEERFAWDGVMV 247
Cdd:cd17370 166 ALLALLILLFVVKEYPRPPKLRKKSKKT-------SLKKLPKAFWLYLLAVALFAL-GNFSFAFLILRAQELGLSAALIP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 248 GVsLAVFGLTHALFqGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACG-GITLPALQGIISVR 326
Cdd:cd17370 238 LL-YALFNLVYALA-AYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 516391490 327 VGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYsatrETWN-GWVWIIGCGLYVVALIIL 384
Cdd:cd17370 316 VPAELRGTAYGLFNTVVGIGWLLASLIAGYLW----DLISpSAAFLFSAVLALIALLLL 370
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
44-385 |
1.88e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 52.63 E-value: 1.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 44 GVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLGRLIAGITGATgavaastiadVTP 123
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGS----------VQP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 124 EESR--THWF-----GM------MGACFGGGmIAGPVIGGFAGQLSVQAPFMFAAAINGLAFLVSLFILHETHNANQVSd 190
Cdd:cd17475 104 GGGRaiMRWFpprerGLamgirqTGVPLGGA-LAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAAT- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 191 elknETINETTSSIREMISPLSGLLVVFFIIQLIGQIPA--TLWVLFGEERFAWDGVMVGVSLAVFGLTHALFQgLAAGF 268
Cdd:cd17475 182 ----ESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFAllTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGR-IGLGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 269 IAKHL--GERKAIAVGI-LADGCGLFLLAVITQSWMVWPVLLLLACGGITLPALQGI----ISVRVGQVAQGQLQGVLTS 341
Cdd:cd17475 257 VSDRVfgGRRRPVLVITaAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLyltlVAESAGPEQAGTALGLANT 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 516391490 342 LTHLTGVIGPLVFAFLYSATRETwnGWVWIIGCGLYVVALIILR 385
Cdd:cd17475 337 INFIGIAIGPPLFGLLVDATHSY--APAWLALALLLVLAALLLL 378
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
5-179 |
2.97e-07 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 52.19 E-value: 2.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 5 VMMALviiFLDAMGIGIIMPVLPALLREFVgkanvaeNYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLD 84
Cdd:cd17384 5 VYVAL---LLDNMLLTVVVPIIPDYLNENV-------RVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFIS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 85 YALMATASVVWVLYLGRLIAGITGATGAVAA-STIADVTPEE-SRTHwfgMMGACFGG---GMIAGPVIGGFAGQL-SVQ 158
Cdd:cd17384 75 TLLFAFGESYGVLFLARALQGVGSACSSVAGmGMLASLYPDDkERGK---AMGIALGGlalGVLVGPPFGGVMYEFvGKS 151
|
170 180
....*....|....*....|.
gi 516391490 159 APFMFAAAINGLAFLVSLFIL 179
Cdd:cd17384 152 APFLILAFLALLDGALQLFIL 172
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
1-176 |
3.81e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.78 E-value: 3.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 1 MNRTVMMALVIIFLDAMGIGIIMPVLPALLREFVGKANVAEnyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLG 80
Cdd:cd17324 196 RNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAI--IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 81 ATLDYALMATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFA-GQLSVQA 159
Cdd:cd17324 274 AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVlDHGGWAG 353
|
170
....*....|....*..
gi 516391490 160 PFMFAAAINGLAFLVSL 176
Cdd:cd17324 354 VGWVGAALLLLALLLAL 370
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
13-350 |
1.15e-06 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 50.01 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 13 FLDAMGIGIIMPVLPALLREFVGKANVAenyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLL-----SLLGATLDYAL 87
Cdd:TIGR00900 9 LISLIGTAITQVALPLYVLAGTGSASVL---SLAALAGMLPYVVLSPIAGALADRYDRKKVMIGadlirAVLVAVLPFVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 88 MATASVVWVLYLGRLIAGITGATGAVA-ASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLsvqAPFMFAAA 166
Cdd:TIGR00900 86 LLGGLNIWQVYVLAGILAIAQAFFTPAyQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYAT---LGIKWAIW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 167 INGLAFLVS---LFILHETHNANQVSDELKNETINETTSSIREMIS--PLSGLLVVFFIIQLIGQIP-ATLWVLFGEERF 240
Cdd:TIGR00900 163 VDAVGFAISallIVSVRIPELAASEIQALSNAVLRDTREGIKFVLKnpLLRTLLLLALLFNLVFAPAiVALFPYVQSKYL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 241 AWDGVMVGVSLAVFGLThALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAvITQSWmvWPVLLLLA-----CGGIT 315
Cdd:TIGR00900 243 GRGSTHYGWVLAAFGLG-ALLGALLLGLLGRYFKRMALMTGAIFVIGLAILVVG-LTPPN--FPLFLVLWfaigvGYGPI 318
|
330 340 350
....*....|....*....|....*....|....*
gi 516391490 316 LPALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIG 350
Cdd:TIGR00900 319 NVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLG 353
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
47-387 |
1.50e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 49.92 E-value: 1.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 47 LALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLGrliAGITGATGAvaasTIADVTPEES 126
Cdd:cd17353 44 FTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLG---YGVLGGIGA----GIGYITPVST 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 127 RTHWF--------GMMGACFGGG-MIAGPVIGGFAGQLSVQAPFMFAAAINGLAFLVSLFILHETHNANQVSDELKNETI 197
Cdd:cd17353 117 AVKWFpdkrglatGIVIAGFGLGsLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANN 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 198 NETTS---SIREMISPLSG--LLVVFFIIQLIGQIPATLWVLFGEERFAWDGVMVGVSLAVFGLTHALFQGLaAGFIAKH 272
Cdd:cd17353 197 AENSPrdyTPREMLRTPTFwlLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPF-WGWLSDK 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 273 LGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLA--CGGITLPALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIG 350
Cdd:cd17353 276 IGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIgfCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIG 355
|
330 340 350
....*....|....*....|....*....|....*..
gi 516391490 351 PLVFAFLYSATreTWNGwVWIIGCGLYVVALIILRFF 387
Cdd:cd17353 356 PIIAAYVLYTG--GYNA-AFIIAAALSLVALALALLL 389
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-178 |
1.72e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.54 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 2 NRTVMMALVIIFLDAMGIGIIMPVLPALLREFVGKANVAenYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGA 81
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAG--YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 82 TLDYALMATASVVWVLYLGRLIAGITGATGAVAASTIAD-VTPEESRTHWFGMMGACFGGGMIAGPVIGG-FAGQLSVQA 159
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQlRVPDELRGRVFSVYNALNSGAMPLGALLAGlLADALGLSA 364
|
170
....*....|....*....
gi 516391490 160 PFMFAAAINGLAFLVSLFI 178
Cdd:cd06173 365 VFLLAGALLLLAALLLLLL 383
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
8-180 |
1.92e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 49.93 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 8 ALVIIFLDAMGIGIimpVLPALLREFVGKANVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYAL 87
Cdd:cd06179 2 ALCLAYFAQLFGVT---LPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 88 MATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQA---PFMFA 164
Cdd:cd06179 79 AGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGwrwIFYIN 158
|
170
....*....|....*.
gi 516391490 165 AAINGLAFLVSLFILH 180
Cdd:cd06179 159 AIFNALALILLFFFYH 174
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
4-178 |
7.39e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 47.96 E-value: 7.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 4 TVMMALVIIFLDAMGIGIIMPVLPALLREFVGKANVAEN----YGVLLALYAMMQVIFApllGRWSDRIGRRPVLLLSLL 79
Cdd:cd17358 3 ATFVANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVAqfswFGSLLTLGALIGALLS---GKLADRIGRKRTLLISAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 80 GATLDYALMATASVVWVLYLGRLIAGIT-GATGAVAASTIADVTPEESRthwfGMMGACF----GGGMIAGPVIGGFagq 154
Cdd:cd17358 80 PCILGWLLIAFAKDVWMLYLGRFLAGFGgGAASVVVPVYIAEIAPKNVR----GALGSLNqllvNIGILLGYVLGSF--- 152
|
170 180
....*....|....*....|....
gi 516391490 155 LSVQAPFMFAAAINGLAFLVSLFI 178
Cdd:cd17358 153 LPWRTLALIGAIPPVVFLILLFFI 176
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
45-360 |
1.01e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.32 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 45 VLLALYAMMQVIFAPLLgrwSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLGRLIAGITGATGAVAASTIADVTPE 124
Cdd:cd17333 38 SSQNAGYLIGSLLAGFL---MKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 125 ESRTHWFGMMGACFGGGMIAGPVIGGFAGQ--LSVQAPFMFAAAInglAFLVSLFILHETHNANQVSDELKNETINETTS 202
Cdd:cd17333 115 ESSATRLNVLHGFFGLGALIGPLIATSLLTseLSWSWAYLIIGLI---YLLLAILILLTLFPELPSARNPQQSVGAFSAS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 203 SIREMISPLSGLLVVFFIIQLIGQIPATLWV-LFGEERFAWDGVMVGVSLAVFGLTHALFQgLAAGFIAKHLGERKAIAV 281
Cdd:cd17333 192 ASRLLRNPSIILGALALFLYVGAETAFSSWVpSYLVEKKHVSDGLAGYLLSGFWVGITIGR-LLGGPISRRIKPHTLLVL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 282 GILADGCGLFLLAVI-TQSWMVWPVLLLLACGGITLPALQGIISVRVgQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSA 360
Cdd:cd17333 271 SGSGALLGLLILLLApTLVVGLVATALLGLFMAALFPTILSLGISNL-PYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEA 349
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
5-181 |
1.10e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 47.23 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 5 VMMALVIIFLDAMGIGIIMPVLPALLREFvgkaNVAENYGVLLAL-YAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATL 83
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDF----LIDDSLAGLLQTvFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 84 DYALMATASVVWVLYLGRLIAGITGATGAVAAST-IADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSV--QAP 160
Cdd:cd17328 77 ATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTiIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGgwRWA 156
|
170 180
....*....|....*....|.
gi 516391490 161 FMFAAAINGLAFLVSLFILHE 181
Cdd:cd17328 157 FRVTGVLGVLLAILLLLFVRE 177
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
25-394 |
1.15e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 47.07 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 25 VLPALLREFVGKANVAEN---YGVLLALYAMMQVIFAPLLGRWSDRIGRRP--VLLLSLLGATLDYALMATASVVWVLYL 99
Cdd:COG2270 33 VFPPYFTSVAALGDPAAAtalWGYALAIAGLLVALLAPVLGAIADRSGRKKpfLAFFTLLGVLATAALFFVAPGGLWLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 100 GRLIAGITGATGAVA--ASTIADVTPEESRTHWFGmMGACFG--GGMIA----------GPVIGGFAGQLSVQAPFMFAA 165
Cdd:COG2270 113 LLFVLANIGFEGSLVfyNAFLPDIATPEEIGRVSG-LGWALGylGGVLLllinlalflkPEAFGLPDAGEAVRISFLLTA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 166 AINGLAFLVSLFILHETHNANQVSD-ELKNETINETTSSIREMIS--PLSGLLVVFFIIQLIGQIPATLWVLFGEERFAW 242
Cdd:COG2270 192 LWWLLFALPLFLFLPERPRPGPAPPrGAVRAGFRELRRTLRELRRyrDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGF 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 243 DGVMVGVSLAVFGLTHALFqGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWpvlLLLACGGITLPALQGI 322
Cdd:COG2270 272 STTELIVFGLLVQIVAALG-ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFW---ILGLLIGLVMGGIQAL 347
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516391490 323 ISVRVGQVAQGQLQGVLTSLTHLTG----VIGPLVFAFLYSATRETWNGwvwIIGCGLY-VVALIILRFFHPGRVIH 394
Cdd:COG2270 348 SRSLLARLIPPGREAEFFGLYALSGkaasFLGPLLFGLVTQLTGSQRLG---ILSLIVFfVIGLVLLLRVKVPRGRA 421
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
3-176 |
1.44e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.78 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 3 RTVMMALVIIFLDAMGIGIIMPVLPALL-REFVGKANVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGA 81
Cdd:cd17478 191 KGVWRALLLLLIIVFLRSWVLSSLTTFLpFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLA 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 82 TLDYALMATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQAPF 161
Cdd:cd17478 271 APFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVL 350
|
170
....*....|....*
gi 516391490 162 MFAAAINGLAFLVSL 176
Cdd:cd17478 351 LILALLPLLGALLAF 365
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
13-309 |
1.70e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.40 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 13 FLDAMGIGIIMPVLPALLREFVGKANVAenyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATAS 92
Cdd:cd17478 6 FLNDFYQGFLPALLPLLIAKLGLSYAQA---GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 93 VVWVLYLGRLIAGITGATGAVAASTIADVTPEESRThwFGMMGACFGG--GMIAGPVIGGFAGQLSVQAPFMFAAAINGL 170
Cdd:cd17478 83 NYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRG--LAMSIFSVGGnlGFALGPLIAAALVALFGGLGLLILLIIPGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 171 AFLVSLFILHETHNANQVsdelKNETINETTSSIREMISPLSGLLVVFFIIQLIGQIPATLWVLFGEERFaWDGVMVGVS 250
Cdd:cd17478 161 AVALLLLRLRPLKKPEAK----KAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLL 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 516391490 251 LAVFGLTHAlFQGLAAGFIAKHLGERKAIAVGILAdGCGLFLLAVITQSWMVWPVLLLL 309
Cdd:cd17478 236 LSLFLFAGA-IGTLIGGPLSDRFGRRRVIIASLLL-AAPFLLLFLLTPGIWSYILLVLA 292
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
214-389 |
1.85e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 46.27 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 214 LLVVFFIIQLIGQIPATLWVLFgEERFAWDGVMVGVSLAVFGLTHALFQgLAAGFIAKHLGERKAIAVGILADGCGLFLL 293
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPAL-LQSFGLSASQLGLLFALFSLGYALLQ-PLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 294 AVITQSWMVWPVLLLLACG-GITLPALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETWNGWVWII 372
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGsGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170
....*....|....*..
gi 516391490 373 GCGLYVVALIILRFFHP 389
Cdd:cd06174 159 AALALLAAILLLLVVPD 175
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
9-177 |
2.33e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 46.06 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 9 LVIIFLDAMGIGIIMPVLPALLREFVGKAnvAENYGVLLALYAMMQVIF-APLLGRWSDRIGRRPVLLLSLLGATLDYAL 87
Cdd:cd17331 213 LLVKLLSGLPIGMFQSMFSLVAMDFFGLT--PEENGYLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGYLL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 88 MATASVVWVLYLGRLIAGITGATGAVAA-STIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFA-GQLSVQAPFMFAA 165
Cdd:cd17331 291 LAFVTTVWQLLVLLLPLVIGGSVLYTVItSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALlQAYGFPSFGLLGA 370
|
170
....*....|..
gi 516391490 166 AINGLAFLVSLF 177
Cdd:cd17331 371 AINGLLTVYLLL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
214-385 |
3.05e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 3.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 214 LLVVFFIIQLIGQIPATLWVLFGEERFAWDGVMVGVSLAVFGLTHALFQgLAAGFIAKHLGERKAIAVGILADGCGLFLL 293
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 294 AVITQSWMVWPVLLLL-ACGGITLPALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETWNGWVWII 372
Cdd:pfam07690 80 LFASSLWLLLVLRVLQgLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170
....*....|...
gi 516391490 373 GCGLYVVALIILR 385
Cdd:pfam07690 160 LSLLAAVLLLLPR 172
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
3-387 |
3.43e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 45.45 E-value: 3.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 3 RTVMMALVIIFLDAMGIGIIMPVLPALLREFVGKANVAEnygVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGAT 82
Cdd:TIGR00710 5 AFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQ---MTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 83 LDYALMATASVVWVLYLGRLIAGITGATGAVAA-STIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQ-LSVQAP 160
Cdd:TIGR00710 82 LSSLGLALSNNIETLLVLRFVQAFGASAGSVISqALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVwLSWHAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 161 FMFAAAINGLAFLVSLFILHETHnanqvsdelKNETINETTSSIREMISPLSGLLVVFFIIqLIGQIPATLWVLFGEERF 240
Cdd:TIGR00710 162 FAFLSLAGILLSALIFFILPETL---------PYEARIQISTYFETFLLLLKSKMFWGYAL-IYGASFGGFFAFFSGAPF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 241 AWDGVMvGVSLAVFGLTHAL--FQGLAAGFIAKHLGeRKAIAVGILADGCGLF----LLAVITQSWMVWPVLLLLACGGI 314
Cdd:TIGR00710 232 VYIDIM-GVSPSVFGLLFALniIAMIFGGFLNGRFI-KKWGAKSLLRMGLILFavsaVLLEITAILGLGSWAMIIGPMMF 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516391490 315 TLPALQGIISVRVGQV--AQGQLQGVLTSLTH-LTGVIGPLVFAFLYSATRETwnGWVWIIGCGLYVVALIILRFF 387
Cdd:TIGR00710 310 VGIGNSMISSIAMAYAleDFPHVAGTASALFGtLRLVLGAIVGYLVSLIHGNT--AWPMSLSCLVLAVVSVLAFYY 383
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
2-178 |
3.48e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.65 E-value: 3.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 2 NRTVMMALVIIFLDAMGIGIIMPVLPALL--REFVGKANVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLL 79
Cdd:cd17504 176 RRNVLLANITALLAGFGMFMVFQLLPQLLqlPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLV 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 80 GATLDYALMAT-ASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRT-HWFGMMGACFGGGMIAGPVI--------- 148
Cdd:cd17504 256 ISAVGLLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTgIATGMNTVLRTIGSAIGPAIagailttyt 335
|
170 180 190
....*....|....*....|....*....|....*
gi 516391490 149 -----GGFAGQLSVQAPFMFAAAINGLAFLVSLFI 178
Cdd:cd17504 336 vsitsGGVPTEGAYVLAFLIGAALALAALLLSLLI 370
|
|
| MFS_SLC46A2_TSCOT |
cd17450 |
Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the ... |
238-382 |
4.42e-05 |
|
Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 2 (SLC46A2) is also called thymic stromal cotransporter protein (TSCOT). It is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. Polymorphisms in TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. TSCOT belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341008 Cd Length: 383 Bit Score: 45.13 E-value: 4.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 238 ERFAWDGVMVGVSLAVfGLTHALFQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLLLACGGITLP 317
Cdd:cd17450 234 EPLSWGAVEVGYGNAA-GYMIFITSFLGVFVFSRCLRDTTMIMIGMVSFSSGILIMAFVKWTFMFYIARAVMLFALIPLP 312
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516391490 318 ALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYSATRETWNGWVWIIGCGLYVVALI 382
Cdd:cd17450 313 TIRSLISKQVQGSSYGKVFVMLQLSLKLTGVATSTIYNKIYQATLDWFPGFCFILSSILGFLSII 377
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-177 |
4.96e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.26 E-value: 4.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 44 GVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLGRLIAGI-TGATGAVAASTIADVT 122
Cdd:cd17473 236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLV 315
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 516391490 123 PEESRTHWFGMMGACFGGGMIAGPVIGGFAGQL--SVQAPFMFAAAINGLAFLVSLF 177
Cdd:cd17473 316 PPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLtgGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
2-180 |
9.16e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.11 E-value: 9.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 2 NRTVMMALVIIFLDAMGIGIIMPVLPALLREFVGKANVaenYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGA 81
Cdd:cd17335 197 NPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTL---IGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAY 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 82 TLDYALMATASVVWVLYLGRLIAGIT-GATGAVAASTIADVTPEESRTHWFGMMGA-CFGGGMIAGPVIGGFA-GQLSVQ 158
Cdd:cd17335 274 VVRWLLYSFLENPWLVLPIELLHGLTfALVWAAAVSYASAAAPPGLRATAQGLLQGlYFGLGGGLGSLIGGYLyEAFGAR 353
|
170 180
....*....|....*....|..
gi 516391490 159 APFMFAAAInGLAFLVSLFILH 180
Cdd:cd17335 354 TTFRFFAIA-ALAGLLAFFLIQ 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
3-177 |
1.39e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.74 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 3 RTVMMALVIIFLDAMGIGIIMPvLPALLREFVGkaNVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGAT 82
Cdd:cd17316 178 RTLLLILLWFFISFGYYGLTTF-LPTYLQTVLG--LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 83 LD---YALMATASVVWVLYLGRLIAGITGATGAVAASTIADVTPEESRTHWFGM-MGACFGGGMIAGPVIGGFAGQLSVQ 158
Cdd:cd17316 255 ILalpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGGT 334
|
170
....*....|....*....
gi 516391490 159 APFMFAAAINGLAFLVSLF 177
Cdd:cd17316 335 GVPALILALLAIVALIVAL 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
201-389 |
1.52e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.42 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 201 TSSIREMISPLSGLLVVFFIIQLIGQIPATLWVLFGEErFAWDGVMVGVSLAVFGLTHALFQgLAAGFIAKHLGERKAIA 280
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 281 VGILADGCGLFLLAVITQSWMVWPVLLLL-ACGGITLPALQGIISVRVGQVAQGQLQGVLTSLTHLTGVIGPLVFAFLYS 359
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLWLLLAARFLQgLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190
....*....|....*....|....*....|
gi 516391490 360 ATreTWNgWVWIIGCGLYVVALIILRFFHP 389
Cdd:COG2814 160 LF--GWR-WVFLVNAVLALLALLLLLRLLP 186
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-181 |
1.94e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.11 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 3 RTVMMALVIIFLDAMGIGIIMPVLPALLREFvGKANVAENYGVLLALYAMMqvIFAPLLGRWSDRIGRRPVLLLSLLGAT 82
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEW-GLDPVQLGFLFSAGLIGMA--FGALFFGPLADRIGRRRVLLWSILLFS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 83 LDYALMATASVVWVLYLGRLIAGI-TGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAG-QLSVQAP 160
Cdd:TIGR00895 94 VFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIpVFGWRSL 173
|
170 180
....*....|....*....|.
gi 516391490 161 FMFAAAINGLAFLVSLFILHE 181
Cdd:TIGR00895 174 FYVGGIAPLLLLLLLMRFLPE 194
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
5-178 |
3.40e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.57 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 5 VMMALVIIFLDAMGIGIIMPVLPALLREF-VGKANVAENYGvlLALYAMMqvIFAPLLGRWSDRIGRRPVLLLSLLGATL 83
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWgLSPAQLGPVGS--AALFGMA--IGALLAGPLADRFGRKRVLLVSVALFGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 84 DYALMATASVVWVLYLGRLIAGItgATGAVAASTIAdVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQA---- 159
Cdd:cd17365 77 FTLLTAFAQSVLQLALLRFLTGL--GLGAAMPNAIT-LVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAfgwr 153
|
170
....*....|....*....
gi 516391490 160 PFMFAAAINGLAFLVSLFI 178
Cdd:cd17365 154 SVFLLGGVPPLILLPLLRG 172
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
50-314 |
3.95e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.18 E-value: 3.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 50 YAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLGRLIAGITGATGA-VAASTIADVTPEESRT 128
Cdd:cd17503 40 YLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKRG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 129 HWFGMMGACFGGGMIAGPVIGGF-AGQLSVQAPFMFAAAINGLAFLVSLFIlhethnanqvsdELKNETINETTSSIrem 207
Cdd:cd17503 120 AAMGLVGLVILLAPAIGPTLGGWlTDNLSWRWIFYINLPIGILALLLAPLL------------DLRLFKDRNFTLGL--- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 208 ispLSGLLVVFFIIQLIGQIPatlwvLFGEERFAWDGVMVGVSLAVFGLTHALFQGLAAGFIAKhLGERKAIAVGILADG 287
Cdd:cd17503 185 ---LLSFLLGLGLFGAMFLLP-----LYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDK-FGPRLLLLAGLLLLA 255
|
250 260
....*....|....*....|....*..
gi 516391490 288 CGLFLLAVITQSWMVWPVLLLLACGGI 314
Cdd:cd17503 256 LGTLLLAFLTPDTSLWLIILPLFIRGL 282
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
19-183 |
4.43e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.18 E-value: 4.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 19 IGIIMPVLPALLREFVGKANVAENYGVLLALY--AMMQVIFAPLLgrwSDRIGRRPVLLLSLLGATLDYALMATASVVWV 96
Cdd:cd17315 13 LGVINGALLYIAKDLGFGLSTSLQGLVVSSLLlgAAIGSLFGGPL---ADRFGRRKSLLIAAVLYVIGALLSALAPNVWV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 97 LYLGRLIAGI-TGATGAVAASTIADVTPEESRthwfGMMGACFG----GGMIAGPVIG-GFAGQLSVQAPFMFA-AAING 169
Cdd:cd17315 90 LIVGRFLLGLgVGLASVLVPLYISEIAPAKIR----GALGTLNQlmitFGILLAYLLGlALSLSPPGWWRLMFAlAAVPA 165
|
170
....*....|....
gi 516391490 170 LAFLVSLFILHETH 183
Cdd:cd17315 166 LLQLLLMFFLPESR 179
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
1-176 |
9.44e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 9.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 1 MNRTVMMALVIIFLDAMGIGIIMPVLPALLREFVGKAnvAENYGVLLALYAMMQVIFAPLLGRWSDR-IGRRPVLLLSLL 79
Cdd:cd06174 201 KNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS--VAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 80 GATLDYALMATASVVWVLYLGRLIAGITGATG-AVAASTIADVTPEESRTHWFGMMGAC-FGGGMIAGPVIGGF-AGQLS 156
Cdd:cd06174 279 LMALGLALLLLAPSLLLLLLLLLLLGFGLGGLlPLSFALIAELFPPEIRGTAFGLLNTFgFLGGAIGPLLAGFLlAATFG 358
|
170 180
....*....|....*....|
gi 516391490 157 VQAPFMFAAAINGLAFLVSL 176
Cdd:cd06174 359 LTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
10-167 |
1.24e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 40.76 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 10 VIIFLDAMGIGIIMPVLPALLREFVgkanvaeNYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMA 89
Cdd:cd17383 6 IALLLDNMLYMVIVPIIPDYLNEDI-------AIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 90 TASVVWVLYLGRLIAGITGATGAVAA-STIADVTPEES-RTHWFGMMGACFGGGMIAGPVIGG----FAGQlsvQAPFMF 163
Cdd:cd17383 79 FGESYAVLFFARSLQGVGSAFADTAGlAMIADRFTEEAeRSKALGIALAFISFGCLVAPPFGGilyeFAGK---EVPFLI 155
|
....
gi 516391490 164 AAAI 167
Cdd:cd17383 156 LAFV 159
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
44-173 |
1.41e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 40.61 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 44 GVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLGRLIAGIT-GATGAVAASTIADVT 122
Cdd:cd17471 238 GLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFiGITAGLGISYFQDLM 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 516391490 123 PEE---SRTHWFGMMGAcfgGGMIAGPVIGGFAGQLSVQAPFMFAAAINGLAFL 173
Cdd:cd17471 318 PGQpglATTLYSNASRI---GSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
20-182 |
2.13e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 39.95 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 20 GIIMPVLPALLREFVGKANVAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYL 99
Cdd:cd17360 14 GVISGALLYIKDDLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 100 GRLIAGI-TGATGAVAASTIADVTPEESRTHWFGMMGACFGGGMIAGPVIGGFAGQLSVQAPFMFA-AAINGLAFLVSLF 177
Cdd:cd17360 94 GRVLVGLgVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGlAAVPAVLQFIGLL 173
|
....*
gi 516391490 178 ILHET 182
Cdd:cd17360 174 FLPES 178
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
13-386 |
2.89e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.49 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 13 FLDAMGIGIIMPVLPALLREfVGKAnvAENYGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATAS 92
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQ-LGLS--PTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 93 VVWVLYLgrLIAGITGATGAVAASTIADV---TPEESRTHWFG---MMGAcFGGG---MIAGPVIGGFAGQLSVQAPFMF 163
Cdd:cd17335 84 AQIFWLL--LLLVILGAFFSAPVVPLVDSitlQYLGEERERYGkqrLWGS-IGFGiaaLLVGILIDRSSTYKNYTIAFYV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 164 AAAINGLAFLVSLFILHEThnanqvsdelKNETINETTSSIREMISPlSGLLVVFFIIQLIGQIPATLWVLfgeerFAWD 243
Cdd:cd17335 161 FAVLMLLALLLALKFPFRP----------KHPEPNENTGGLLALLRN-PRVLAFLLVAFLMGFGHGLIYSF-----LFWH 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 244 GVMVGVSLAVFGLTHAL------FQGLAAGFIAKHLGERKAIAVGILADGCGLFLLAVITQSWMVWPVLLL--LACGGIT 315
Cdd:cd17335 225 LQDLGGSKTLIGLLWTVgvvseiPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLhgLTFALVW 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516391490 316 LPALQgIISVRVGQVAQGQLQGVLTSLTH-LTGVIGPLVFAFLYSATRETWNGWVWIIGCGLYVVALIILRF 386
Cdd:cd17335 305 AAAVS-YASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
214-382 |
2.99e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 39.91 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 214 LLVVFFIIQLIGqipatlwvlfGEERfawdGVMVGVSLAVFGLTHALFQGLAaGFIAKHLGERKAIAVGILAdGCGLFLL 293
Cdd:PRK08633 30 ILIQNTLIKAYD----------GSEQ----VILTAIVNALFLLPFLLLSSPA-GFLADKFSKNRVIRIVKLF-EVGLTLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 294 AVITQS----WMVWPVLLLLAC-GGITLPALQGIISVRVGQVAQGQLQGVLTSLTHLT----GVIGPLVFAFLYSATRET 364
Cdd:PRK08633 94 IVLAYYlgwfWLAFAVTFLLGAqSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAilagTALFSFLFESVNGNTPSE 173
|
170
....*....|....*...
gi 516391490 365 WNGWVWIIGCGLYVVALI 382
Cdd:PRK08633 174 ILGRIAPAGLVLLAVAVL 191
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
24-137 |
3.62e-03 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 39.43 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 24 PVLPALLREFVGKANV----AENYGVLLALYAMMQVIFAPLLgrwSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYL 99
Cdd:cd17434 23 PVIPALEQGDDPRLHLnvhqISWFGSVFTLGAAAGGLSAMFL---NDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLL 99
|
90 100 110
....*....|....*....|....*....|....*...
gi 516391490 100 GRLiagITGATGAVAASTIADVTPEESRTHWFGMMGAC 137
Cdd:cd17434 100 GRF---LTGFAGGITAASIPVYVSEISHPGVRGALGAC 134
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
59-312 |
5.19e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 38.85 E-value: 5.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 59 PLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLGRLIAGI-TGATGAVAASTIADVTPEESRTHWFGMMGac 137
Cdd:PRK10473 56 LFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIgAGCCYVVAFAILRDTLDDRRRAKVLSLLN-- 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 138 fgGGMIAGPVIGGFAGQLSV-----QAPFMFAAAINGLAFLVSLFILHETHNANQVSDELKNETINETTSSIREMISPLS 212
Cdd:PRK10473 134 --GITCIIPVLAPVLGHLIMlkfpwQSLFYTMAAMGILVLLLSLFILKETRPARAPAASSKPRENSESLLNRFFLSRLVI 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 213 GLLVVFFIIQLIGQIPATLWVLFGEERFAWDGVMV---GVSLAVFGLThalfqglaaGFIAKHLGERKAIAVGILADGCG 289
Cdd:PRK10473 212 TTLSVTVILTFVNTSPVLLMEQMGFSRGEYAIIMAltaGVSMTVSFST---------PFALGIFKPRTLMLTSQVLFLAA 282
|
250 260
....*....|....*....|...
gi 516391490 290 LFLLAVITQSWMVWPVLLLLACG 312
Cdd:PRK10473 283 GITLALSPSHAVSLFGITLICAG 305
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
43-174 |
5.45e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.78 E-value: 5.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 43 YGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASVVWVLYLGRLIAGITGATGAVAASTIADVT 122
Cdd:cd17393 36 LGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAMNAQGVAV 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 516391490 123 PEESRTHWFGMMGACFGGGMIAGPVIGGFAG--QLSVQAPFMFAAAINGLAFLV 174
Cdd:cd17393 116 ERAYGRPIMSSLHAMWSLGGLAGALLGAAAIgaGVSPGVHLLAAAVLLLLAALV 169
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-296 |
9.40e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.05 E-value: 9.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 14 LDAMGIGIIMPVLPALLREFVGKAnvaenyGVLLALYAMMQVIFAPLLGRWSDRIGRRPVLLLSLLGATLDYALMATASV 93
Cdd:cd17371 13 FDLLLLGLVLPALIAEFGLDEAEA------GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 94 VWVLYLGRLIAGI-TGATGAVAASTIADVTPEESRTHWFG--MMGACFGGGM---IAGPVIGGFAGQLSVQAPFMFAAAI 167
Cdd:cd17371 87 YWQLLILRALAGLgFGGEWAAGAALMAEYVPARHRGKALGyvQSGWAVGWLLatlLAALLFPLLPPEIAWRVLFLLGALP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516391490 168 NGLAFLVSLFiLHETHNANQVSDELkneTINETTSSIREMISP----LSGLLVVFFIIQLIGQIPATLWV---LFGEERF 240
Cdd:cd17371 167 ALLVLFIRRF-VKEPPQWQAARAAR---RHFADRPSLRELFSPpllrTTLLASLLATGALGGYYGITTWLpsyLTGERGL 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 516391490 241 AwdgvMVGVSLAVFGLTHALFQG-LAAGFIAKHLGERKAIAVGILadGCGLFLLAVI 296
Cdd:cd17371 243 S----FEGSAGYLVVTILGGFLGyLAGGFLADRIGRRNNFALFAL--GSAISILLYF 293
|
|
| |
