|
Name |
Accession |
Description |
Interval |
E-value |
| strep_PBP3 |
NF038273 |
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ... |
16-419 |
6.81e-125 |
|
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.
Pssm-ID: 468443 [Multi-domain] Cd Length: 407 Bit Score: 368.43 E-value: 6.81e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 16 ILVFTSMLTATTTVQANELDLVSESAILVDGETGKVLYAKNPDVALPPASMTKMMTEYLVWEAIENGNITWDTTTEISDY 95
Cdd:NF038273 6 LLLLLLAFFLATTVSADDFDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTPVKISDY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 96 PYSISANNSFSGVGLkQQQEYTVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEMGLQEFKFVNSTGLDNE 175
Cdd:NF038273 86 PYELTTNYEISNVPL-DARKYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNASGLNNS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 176 DLGDN-YPeGTNPNDTNLLSARSAALLAYHLVNDYEEALEISSIPQTTFGGQTINNWNYMLPHegenlASYYYEGVDGLK 254
Cdd:NF038273 165 YLGDHiYP-GSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADFAGTTIYSYNYMLKG-----MPYYREGVDGLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 255 TGFTDLAGYSFTGTAERNGQRLITVVMKT----GSETERFEETAKLLDYGFSNFENTELFSAGyQEEGNETVPVAKGKED 330
Cdd:NF038273 239 TGTTEKAGASFVATSVENGMRVITVVLNAdnadEDEYARFTATNQLLDYIYQNFEKVTLVKKG-QAYKDSKLPVIDGKKK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 331 QVSISLQDSVSVPIKADEKDLYHLEYNIDQDrlnedgELIAPIEANEAIGTAKLVyDGETEDYGYISDAGSntgeFTLVT 410
Cdd:NF038273 318 TVSAVAKKDLTVIQKIGTDSKPSVKFTPKKK------ELTAPIKKGQVVGKATFK-DKDLIGKGYLGEPPS----VELVA 386
|
....*....
gi 516409375 411 NEAVEKSNW 419
Cdd:NF038273 387 KKDVKKSFF 395
|
|
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
1-421 |
3.93e-111 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 330.26 E-value: 3.93e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 1 MRNKLnkvlllavasILVFTSMLTATTTVQANELDLVSESAILVDGETGKVLYAKNPDVALPPASMTKMMTEYLVWEAIE 80
Cdd:COG1686 1 MKKLL----------LLALLLLLAAAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 81 NGNITWDTTTEISDYPYSISAnnsfSGVGLKQQQEYTVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEMG 160
Cdd:COG1686 71 AGKISLDDKVTVSEEAARTGG----SKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 161 LQEFKFVNSTGLDNEDlgdnypegtnpndtNLLSARSAALLAYHLVNDYEEALEISSIPQTTF---GGQTINNWNYMLph 237
Cdd:COG1686 147 MTNTHFVNPTGLPDPG--------------HYSTARDLALLARAAIKDYPEFYEIFSTKEFTFpngRGITLRNTNRLL-- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 238 egenlasYYYEGVDGLKTGFTDLAGYSFTGTAERNGQRLITVVMKTGSETERFEETAKLLDYGFSnfentelfsagyqee 317
Cdd:COG1686 211 -------GRYPGVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYGFP--------------- 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 318 gnetvpvaKGKEDQVSISLqdsvsvpikadekdlyhleynidqdrlneDGELIAPIEANEAIGTAKLVYDGETEdygyis 397
Cdd:COG1686 269 --------KGEALKAEVVL-----------------------------DGPLKAPVKKGQVVGTLVVTLDGKTI------ 305
|
410 420
....*....|....*....|....
gi 516409375 398 dagsntGEFTLVTNEAVEKSNWFM 421
Cdd:COG1686 306 ------AEVPLVAAEDVEKAGFFS 323
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
31-281 |
4.46e-78 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 242.29 E-value: 4.46e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 31 ANELDLVSESAILVDGETGKVLYAKNPDVALPPASMTKMMTEYLVWEAIENGNITWDTTTEISDYPYSISANNSFSGVgL 110
Cdd:pfam00768 1 VSAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNPGSSNIF-L 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 111 KQQQEYTVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEMGLQEFKFVNSTGLDNEDlgdnypegtnpndt 190
Cdd:pfam00768 80 KPGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHG-------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 191 NLLSARSAALLAYHLVNDYEEALEISSIPQTTFggQTINNWNYMLPHegeNLASYYYEGVDGLKTGFTDLAGYSFTGTAE 270
Cdd:pfam00768 146 QYSSARDMAILAKALIKDLPEELSITKEKSFTF--RGINKINQRNRN---GLLWDKTWNVDGLKTGYTNEAGYCLVASAT 220
|
250
....*....|.
gi 516409375 271 RNGQRLITVVM 281
Cdd:pfam00768 221 KGGMRLISVVM 231
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
15-360 |
2.23e-57 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 193.27 E-value: 2.23e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 15 SILVFTSMLTATTTVQANE--LDLVS-------------ESAILVDgETGKVLYAKNPDVALPPASMTKMMTEYLVWEAI 79
Cdd:NF038258 2 VSLLLLSTIITPPASAAAEtpVEIANqegyqnlseqynpEGAIVTT-QTGQILYDYHGNKKWDPASMTKLMTMYLTLEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 80 ENGNITWDTTTEISDYPYSISANNSFSGVGLKQQQEYTVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEM 159
Cdd:NF038258 81 KKGKLSLNDKVKITSDYEKMSTLPNLSTFPLKPGQTYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 160 GLQEFKFVNSTGLDNEDLGDNYPEGTNPNDTNLLSARSAALLAYHLVNDYEEALEISSIPQTTFGGQTINNWNYMLPHEg 239
Cdd:NF038258 161 GMKHTHFTNPSGADNNLLKPYAPKKYKDETKSKSTAKDMAILSQHLIKKHPKILKYTKLTADTQHGVTLYTTNLSLPGQ- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 240 enlaSYYYEGVDGLKTGFTDLaGYSFTGTAERNGQRLITVVMKT------GSETERFEETAKLLDYGFSNFENTELFSAG 313
Cdd:NF038258 240 ----PMSLKGTDGLKTGTSDE-GYNLALTTKRDGLRINQVIMNVgpypseGAKHARNKIANALMERAFKQYEYKKVLSKG 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 516409375 314 YQEegnetvpvAKGKEDQVSISLQDSVSvpikaDEKDLYHLEYNIDQ 360
Cdd:NF038258 315 EHK--------IDGKTYYVKKDLYDVVP-----KDKSKYDLKINKDG 348
|
|
| dacD |
PRK11397 |
serine-type D-Ala-D-Ala carboxypeptidase DacD; |
40-420 |
4.22e-45 |
|
serine-type D-Ala-D-Ala carboxypeptidase DacD;
Pssm-ID: 183117 [Multi-domain] Cd Length: 388 Bit Score: 161.14 E-value: 4.22e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 40 SAILVDGETGKVLYAKNPDVALPPASMTKMMTEYLVWEAIENGNITWDTTTEISDYPYSiSANNSFSGVGL---KQQQEY 116
Cdd:PRK11397 38 SWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRITPDDIVTVGRDAWA-KDNPVFVGSSLmflKEGDRV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 117 TVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEMGLQEFKFVNSTGLDNedlgdnypegtnPNDTNllSAR 196
Cdd:PRK11397 117 SVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLHLKDTHFETVHGLDA------------PGQHS--SAY 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 197 SAALLAYHLVNDYEEALEISSIPQTTFGGQTINNWNYMLPHEGENlasyyyegVDGLKTGFTDLAGYSFTGTAERNGQRL 276
Cdd:PRK11397 183 DLAVLSRAIIHGEPEFYHMYSEKSLTWNGITQQNRNGLLWDKTMN--------VDGLKTGHTSGAGFNLIASAVDGQRRL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 277 ITVVMKTGSETERFEETAKLLDYGFSNFENTELFSAGyQEEGNETvpVAKGKEDQVSISLQDSVSVPIKADEKDLYHLEY 356
Cdd:PRK11397 255 IAVVMGADSAKGREEQARKLLRWGQQNFTTVQILHRG-KKVGTER--IWYGDKENIALGTEQDFWMVLPKAEIPHIKAKY 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516409375 357 NIDQDRLNedgeliAPIEANEAIGTAKLvYDGETEdygyisdagsnTGEFTLVTNEAVEKSNWF 420
Cdd:PRK11397 332 VLDGKELE------APISAHQRVGEIEL-YDRDKQ-----------VAHWPLVTLESVGEGGMF 377
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
304-416 |
1.94e-13 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 65.70 E-value: 1.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 304 FENTELFSAGyqeEGNETVPVAKGKEDQVSISLQDSVSVPIKADEKDLYHLEYNIDQDrlnedgELIAPIEANEAIGTAK 383
Cdd:smart00936 1 FETVKLYKKG---QVVGTVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKP------ELEAPIKKGQVVGTLV 71
|
90 100 110
....*....|....*....|....*....|...
gi 516409375 384 LVYDGETEdygyisdagsntGEFTLVTNEAVEK 416
Cdd:smart00936 72 VTLDGKLI------------GEVPLVALEDVEK 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| strep_PBP3 |
NF038273 |
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ... |
16-419 |
6.81e-125 |
|
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.
Pssm-ID: 468443 [Multi-domain] Cd Length: 407 Bit Score: 368.43 E-value: 6.81e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 16 ILVFTSMLTATTTVQANELDLVSESAILVDGETGKVLYAKNPDVALPPASMTKMMTEYLVWEAIENGNITWDTTTEISDY 95
Cdd:NF038273 6 LLLLLLAFFLATTVSADDFDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTPVKISDY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 96 PYSISANNSFSGVGLkQQQEYTVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEMGLQEFKFVNSTGLDNE 175
Cdd:NF038273 86 PYELTTNYEISNVPL-DARKYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNASGLNNS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 176 DLGDN-YPeGTNPNDTNLLSARSAALLAYHLVNDYEEALEISSIPQTTFGGQTINNWNYMLPHegenlASYYYEGVDGLK 254
Cdd:NF038273 165 YLGDHiYP-GSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADFAGTTIYSYNYMLKG-----MPYYREGVDGLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 255 TGFTDLAGYSFTGTAERNGQRLITVVMKT----GSETERFEETAKLLDYGFSNFENTELFSAGyQEEGNETVPVAKGKED 330
Cdd:NF038273 239 TGTTEKAGASFVATSVENGMRVITVVLNAdnadEDEYARFTATNQLLDYIYQNFEKVTLVKKG-QAYKDSKLPVIDGKKK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 331 QVSISLQDSVSVPIKADEKDLYHLEYNIDQDrlnedgELIAPIEANEAIGTAKLVyDGETEDYGYISDAGSntgeFTLVT 410
Cdd:NF038273 318 TVSAVAKKDLTVIQKIGTDSKPSVKFTPKKK------ELTAPIKKGQVVGKATFK-DKDLIGKGYLGEPPS----VELVA 386
|
....*....
gi 516409375 411 NEAVEKSNW 419
Cdd:NF038273 387 KKDVKKSFF 395
|
|
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
1-421 |
3.93e-111 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 330.26 E-value: 3.93e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 1 MRNKLnkvlllavasILVFTSMLTATTTVQANELDLVSESAILVDGETGKVLYAKNPDVALPPASMTKMMTEYLVWEAIE 80
Cdd:COG1686 1 MKKLL----------LLALLLLLAAAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 81 NGNITWDTTTEISDYPYSISAnnsfSGVGLKQQQEYTVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEMG 160
Cdd:COG1686 71 AGKISLDDKVTVSEEAARTGG----SKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 161 LQEFKFVNSTGLDNEDlgdnypegtnpndtNLLSARSAALLAYHLVNDYEEALEISSIPQTTF---GGQTINNWNYMLph 237
Cdd:COG1686 147 MTNTHFVNPTGLPDPG--------------HYSTARDLALLARAAIKDYPEFYEIFSTKEFTFpngRGITLRNTNRLL-- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 238 egenlasYYYEGVDGLKTGFTDLAGYSFTGTAERNGQRLITVVMKTGSETERFEETAKLLDYGFSnfentelfsagyqee 317
Cdd:COG1686 211 -------GRYPGVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYGFP--------------- 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 318 gnetvpvaKGKEDQVSISLqdsvsvpikadekdlyhleynidqdrlneDGELIAPIEANEAIGTAKLVYDGETEdygyis 397
Cdd:COG1686 269 --------KGEALKAEVVL-----------------------------DGPLKAPVKKGQVVGTLVVTLDGKTI------ 305
|
410 420
....*....|....*....|....
gi 516409375 398 dagsntGEFTLVTNEAVEKSNWFM 421
Cdd:COG1686 306 ------AEVPLVAAEDVEKAGFFS 323
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
31-281 |
4.46e-78 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 242.29 E-value: 4.46e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 31 ANELDLVSESAILVDGETGKVLYAKNPDVALPPASMTKMMTEYLVWEAIENGNITWDTTTEISDYPYSISANNSFSGVgL 110
Cdd:pfam00768 1 VSAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNPGSSNIF-L 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 111 KQQQEYTVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEMGLQEFKFVNSTGLDNEDlgdnypegtnpndt 190
Cdd:pfam00768 80 KPGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHG-------------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 191 NLLSARSAALLAYHLVNDYEEALEISSIPQTTFggQTINNWNYMLPHegeNLASYYYEGVDGLKTGFTDLAGYSFTGTAE 270
Cdd:pfam00768 146 QYSSARDMAILAKALIKDLPEELSITKEKSFTF--RGINKINQRNRN---GLLWDKTWNVDGLKTGYTNEAGYCLVASAT 220
|
250
....*....|.
gi 516409375 271 RNGQRLITVVM 281
Cdd:pfam00768 221 KGGMRLISVVM 231
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
15-360 |
2.23e-57 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 193.27 E-value: 2.23e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 15 SILVFTSMLTATTTVQANE--LDLVS-------------ESAILVDgETGKVLYAKNPDVALPPASMTKMMTEYLVWEAI 79
Cdd:NF038258 2 VSLLLLSTIITPPASAAAEtpVEIANqegyqnlseqynpEGAIVTT-QTGQILYDYHGNKKWDPASMTKLMTMYLTLEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 80 ENGNITWDTTTEISDYPYSISANNSFSGVGLKQQQEYTVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEM 159
Cdd:NF038258 81 KKGKLSLNDKVKITSDYEKMSTLPNLSTFPLKPGQTYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 160 GLQEFKFVNSTGLDNEDLGDNYPEGTNPNDTNLLSARSAALLAYHLVNDYEEALEISSIPQTTFGGQTINNWNYMLPHEg 239
Cdd:NF038258 161 GMKHTHFTNPSGADNNLLKPYAPKKYKDETKSKSTAKDMAILSQHLIKKHPKILKYTKLTADTQHGVTLYTTNLSLPGQ- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 240 enlaSYYYEGVDGLKTGFTDLaGYSFTGTAERNGQRLITVVMKT------GSETERFEETAKLLDYGFSNFENTELFSAG 313
Cdd:NF038258 240 ----PMSLKGTDGLKTGTSDE-GYNLALTTKRDGLRINQVIMNVgpypseGAKHARNKIANALMERAFKQYEYKKVLSKG 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 516409375 314 YQEegnetvpvAKGKEDQVSISLQDSVSvpikaDEKDLYHLEYNIDQ 360
Cdd:NF038258 315 EHK--------IDGKTYYVKKDLYDVVP-----KDKSKYDLKINKDG 348
|
|
| dacD |
PRK11397 |
serine-type D-Ala-D-Ala carboxypeptidase DacD; |
40-420 |
4.22e-45 |
|
serine-type D-Ala-D-Ala carboxypeptidase DacD;
Pssm-ID: 183117 [Multi-domain] Cd Length: 388 Bit Score: 161.14 E-value: 4.22e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 40 SAILVDGETGKVLYAKNPDVALPPASMTKMMTEYLVWEAIENGNITWDTTTEISDYPYSiSANNSFSGVGL---KQQQEY 116
Cdd:PRK11397 38 SWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRITPDDIVTVGRDAWA-KDNPVFVGSSLmflKEGDRV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 117 TVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEMGLQEFKFVNSTGLDNedlgdnypegtnPNDTNllSAR 196
Cdd:PRK11397 117 SVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLHLKDTHFETVHGLDA------------PGQHS--SAY 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 197 SAALLAYHLVNDYEEALEISSIPQTTFGGQTINNWNYMLPHEGENlasyyyegVDGLKTGFTDLAGYSFTGTAERNGQRL 276
Cdd:PRK11397 183 DLAVLSRAIIHGEPEFYHMYSEKSLTWNGITQQNRNGLLWDKTMN--------VDGLKTGHTSGAGFNLIASAVDGQRRL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 277 ITVVMKTGSETERFEETAKLLDYGFSNFENTELFSAGyQEEGNETvpVAKGKEDQVSISLQDSVSVPIKADEKDLYHLEY 356
Cdd:PRK11397 255 IAVVMGADSAKGREEQARKLLRWGQQNFTTVQILHRG-KKVGTER--IWYGDKENIALGTEQDFWMVLPKAEIPHIKAKY 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516409375 357 NIDQDRLNedgeliAPIEANEAIGTAKLvYDGETEdygyisdagsnTGEFTLVTNEAVEKSNWF 420
Cdd:PRK11397 332 VLDGKELE------APISAHQRVGEIEL-YDRDKQ-----------VAHWPLVTLESVGEGGMF 377
|
|
| PRK10793 |
PRK10793 |
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional |
35-392 |
7.15e-39 |
|
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
Pssm-ID: 182736 [Multi-domain] Cd Length: 403 Bit Score: 145.00 E-value: 7.15e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 35 DLVSESAILVDGETGKVLYAKNPDVALPPASMTKMMTEYLVWEAIENGNITWDTTTEISDYPYSiSANNSFSGVG---LK 111
Cdd:PRK10793 43 QIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMKAGKFKETDLVTVGNDAWA-TGNPVFKGSSlmfLK 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 112 QQQEYTVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEMGLQEFKFVNSTGLDNEDlgdnypegtnpndtN 191
Cdd:PRK10793 122 PGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVNALGLKNTHFQTVHGLDADG--------------Q 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 192 LLSARSAALLAYHLVNDYEEALEISSIPQTTFGGQTINNWNYMLPHEGENlasyyyegVDGLKTGFTDLAGYSFTGTAER 271
Cdd:PRK10793 188 YSSARDMALIGQALIRDVPNEYAIYKEKEFTFNGIRQLNRNGLLWDNSLN--------VDGIKTGHTDKAGYNLVASATE 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 272 NGQRLITVVMKTGSETERFEETAKLLDYGFSNFENTELFSAGyQEEGNEtvPVAKGKEDQVSISLQDSVSVPI-KADEKD 350
Cdd:PRK10793 260 GQMRLISAVMGGRTFKGRETESKKLLTWGFRFFETVNPLKVG-KEFASE--PVWFGDSDRASLGVDKDVYLTIpRGRMKD 336
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 516409375 351 LyHLEYNIDqdrlneDGELIAPIEANEAIGTAKLVYDGETED 392
Cdd:PRK10793 337 L-KASYVLN------TSELHAPLQKNQVVGTINFQLDGKTIE 371
|
|
| PRK10001 |
PRK10001 |
serine-type D-Ala-D-Ala carboxypeptidase; |
11-390 |
9.95e-38 |
|
serine-type D-Ala-D-Ala carboxypeptidase;
Pssm-ID: 182189 [Multi-domain] Cd Length: 400 Bit Score: 141.67 E-value: 9.95e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 11 LAVASILVFTSMLTATTTVQANELDLVSESA-ILVDGETGKVLYAKNPDVALPPASMTKMMTEYLVWEAIENGNITWDTT 89
Cdd:PRK10001 11 LAAGSAFLFLFAPTAFAAEQTVEAPSVDARAwILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDM 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 90 TEISDYPYSiSANNSFSGVG---LKQQQEYTVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEMGLQEFKF 166
Cdd:PRK10001 91 VTVGKDAWA-TGNPALRGSSvmfLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 167 VNSTGLDNedlgdnypegtnPNDTNllSARSAALLAYHLVNDYEEALEISSIPQTTFGGQTINNWNYMLPHEGENlasyy 246
Cdd:PRK10001 170 QTVHGLDA------------PGQFS--TARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLN----- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 247 yegVDGLKTGFTDLAGYSFTGTAERNGQRLITVVMKTGSETERFEETAKLLDYGFSNFENTELFSAgyqEEGNETVPVAK 326
Cdd:PRK10001 231 ---VDGMKTGTTAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKP---DATFVTQRVWF 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516409375 327 GKEDQVSISLQDSVSVPIKADEKDLYHLEYNIDQDrlnedgELIAPIEANEAIGTAKLVYDGET 390
Cdd:PRK10001 305 GDKSEVNLGAGEAGSVTIPRGQLKNLKASYTLTEP------QLTAPLKKGQVVGTIDFQLNGKS 362
|
|
| pbpG |
PRK11669 |
D-alanyl-D-alanine endopeptidase; Provisional |
9-263 |
1.77e-17 |
|
D-alanyl-D-alanine endopeptidase; Provisional
Pssm-ID: 236952 Cd Length: 306 Bit Score: 82.81 E-value: 1.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 9 LLLAVASILVFTSMLTATTTVQ--ANELDLVSESAILVDGETGKVLYAKNPDVALPPASMTKMMTEYLVWEAiengNITW 86
Cdd:PRK11669 10 LLLLLAGVPFAPQAVAKTAAATtaSQPQEIASGSAMVVDLNTNKVIYSSNPDLVVPIASITKLMTAMVVLDA----KLPL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 87 DT--TTEISDYPysiSANNSFSGVGLKqqQEYTVKELYEAMAINSDNATTIALAELIAGSESEFVKMMNEKGEEMGLQEF 164
Cdd:PRK11669 86 DEklKVDISQTP---EMKGVYSRVRLN--SEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMNAKAKALGMTNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 165 KFVNSTGLDNEdlgdnypegtnpndtNLLSARSAALL-----AYHLVNdyeealEISSIPQTTFggqTINNWNYMLPHEG 239
Cdd:PRK11669 161 RYVEPTGLSIH---------------NVSTARDLTKLliaskQYPLIG------QLSTTREKTA---TFRKPNYTLPFRN 216
|
250 260
....*....|....*....|....*
gi 516409375 240 ENLASYYYE-GVDGLKTGFTDLAGY 263
Cdd:PRK11669 217 TNHLVYRDNwNIQLTKTGFTNAAGH 241
|
|
| PBP5_C |
pfam07943 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
304-416 |
6.56e-14 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 429749 [Multi-domain] Cd Length: 91 Bit Score: 67.23 E-value: 6.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 304 FENTELFSAGYQEEgneTVPVAKGKEDQVSISLQDSVSVPIKADEKDLYHLEYNIDQDrlnedgeLIAPIEANEAIGTAK 383
Cdd:pfam07943 1 FETKKLYKKGDVVK---KVKVWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKVTLKKP-------LEAPIKKGQVVGKLE 70
|
90 100 110
....*....|....*....|....*....|...
gi 516409375 384 LVYDGETedygyisdagsnTGEFTLVTNEAVEK 416
Cdd:pfam07943 71 VYLDGKL------------IGEVPLVAKEDVEE 91
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
304-416 |
1.94e-13 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 65.70 E-value: 1.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 304 FENTELFSAGyqeEGNETVPVAKGKEDQVSISLQDSVSVPIKADEKDLYHLEYNIDQDrlnedgELIAPIEANEAIGTAK 383
Cdd:smart00936 1 FETVKLYKKG---QVVGTVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKP------ELEAPIKKGQVVGTLV 71
|
90 100 110
....*....|....*....|....*....|...
gi 516409375 384 LVYDGETEdygyisdagsntGEFTLVTNEAVEK 416
Cdd:smart00936 72 VTLDGKLI------------GEVPLVALEDVEK 92
|
|
| PenP |
COG2367 |
Beta-lactamase class A [Defense mechanisms]; |
6-208 |
2.77e-08 |
|
Beta-lactamase class A [Defense mechanisms];
Pssm-ID: 441934 [Multi-domain] Cd Length: 276 Bit Score: 54.90 E-value: 2.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 6 NKVLLLAVASILVFTSMLTATTTVQANELDLVSESAILV-DGETGKVLyAKNPDVALPPASMTKMMTEYLVWEAIENGNI 84
Cdd:COG2367 1 MRLLALLLLAAAAAAPASALEAELAALEAALGGRVGVYVlDLDTGETV-GINADERFPAASTFKLPVLAAVLRQVDAGKL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 85 TWDTTTEISDYPYSisannSFSGV--GLKQQQEYTVKELYEAMAINSDNATTIALAELIAGSEsefvkmMNEKGEEMGLQ 162
Cdd:COG2367 80 SLDERVTLTPEDLV-----GGSGIlqKLPDGTGLTLRELAELMITVSDNTATNLLLRLLGPDA------VNAFLRSLGLT 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 516409375 163 EFKFVNSTGLDNEDLGDNypegtnpndTNLLSARSAALLAYHLVND 208
Cdd:COG2367 149 DTRLDRKEPDLNELPGDG---------RNTTTPRDMARLLAALYRG 185
|
|
| Beta-lactamase2 |
pfam13354 |
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ... |
43-208 |
1.22e-07 |
|
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.
Pssm-ID: 463854 [Multi-domain] Cd Length: 215 Bit Score: 52.28 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 43 LVDGETGKVLyAKNPDVALPPASMTKMMTEYLVWEAIENGNITWDTTteisdYPYSISANNSFSGVGLKQQ--QEYTVKE 120
Cdd:pfam13354 4 VRDLDTGEEL-GINGDRSFPAASTIKVPILLAVLEQVDEGKLSLDER-----LTVTAEDKVGGSGILQYLPdgSQLSLRD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516409375 121 LYEAMAINSDNATTIALAELIAGSEsefvkmMNEKGEEMGLQEfkfvnsTGLDNEDLGDNYPEGTNpndTNLLSARSAAL 200
Cdd:pfam13354 78 LLTLMIAVSDNTATNLLIDRLGLEA------VNARLRALGLRD------TRLRRKLPDLRAADKGG---TNTTTARDMAK 142
|
....*...
gi 516409375 201 LAYHLVND 208
Cdd:pfam13354 143 LLEALYRG 150
|
|
| |
