|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
1-434 |
7.00e-75 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 240.28 E-value: 7.00e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 1 MFRVLLRLYLITIVTYSAAIFLIpKLVIQVFEHR----YVDYNVEQSRGLqklIVKQYQRAPVEHWSQVTEQLGRDFA-P 75
Cdd:PRK10604 1 MRKLFIQFYLLLFVCFLVMTLLV-GLVYKFTAERagrqSLDDLMKSSLYL---MRSELREIPPRDWGKTLKEMDLNLSfD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 76 LKVELLLHQDarYTPEEEQLLAQGKPVIRLGEWGWMAEVsapinPQFAVKLTIPPDPL-----DMNLLYWSMNVLIGAAL 150
Cdd:PRK10604 77 LRIEPLSKYH--LDPASQQRLREGEIVALDDQYTFLQRI-----PRSHYVLAVGPVPYlyylhQMRLLDIALLALIGLSL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 151 LACLLVWLRPHWRDLERLKSTATQLGKGNFGERTRIPPSSNIGSLATVFDTMADDIEHLLNQQRDLLNAVSHELRTPLTR 230
Cdd:PRK10604 150 AFPVFLWMRPHWQDMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 231 LDFGLAL--ALSEDLPQASRERLQSLVAHIRELDelvlellSYSRLQNPAQLPERVEVVLDEFIDSVLGSVDdeLENPEI 308
Cdd:PRK10604 230 LRYRLEMsdNLSAAESQALNRDIGQLEALIEELL-------TYARLDRPQNELHLSEPDLPAWLSTHLADIQ--AVTPEK 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 309 VIDVVLDCSVERFNLDPRLTARALQNLLRNATRYCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSR 388
Cdd:PRK10604 301 TVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSR 380
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 516459578 389 DRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLPSVTD 434
Cdd:PRK10604 381 DRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWHN 426
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
118-430 |
1.78e-53 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 183.22 E-value: 1.78e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 118 INPQFAVKLTIPPDPLDMNLLYWSMNVLIGAALLACLLVWLRPHWRDLERLKSTATQLGKGNFGERTRIPPSSNIGSLAT 197
Cdd:COG5002 70 LLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLA 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 198 VFDTMADDIEHLLNQQRDLLNAVSHELRTPLTRLdFGLALALSE---DLPQASRE----------RLQSLVAHIreldel 264
Cdd:COG5002 150 AVERDITELERLEQMRREFVANVSHELRTPLTSI-RGYLELLLDgaaDDPEERREyleiileeaeRLSRLVNDL------ 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 265 vlelLSYSRLQNPAQLPERVEVVLDEFIDSVLGSVDDELENPEIVIDVVLDCSVERFNLDPRLTARALQNLLRNATRYCD 344
Cdd:COG5002 223 ----LDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTP 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 345 --KRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEAQGGTLTAQASPLGG 422
Cdd:COG5002 299 egGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKG 378
|
....*...
gi 516459578 423 ARFRVWLP 430
Cdd:COG5002 379 TTFTITLP 386
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
202-430 |
1.92e-53 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 178.56 E-value: 1.92e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 202 MADDIEHLLNQQRDLLNAVSHELRTPLTRLDFGL-ALALSEDLPQASR-----------ERLQSLVAHIReldelvlell 269
Cdd:COG2205 5 ALEELEELERLKSEFLANVSHELRTPLTSILGAAeLLLDEEDLSPEERrelleiiresaERLLRLIEDLL---------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 270 SYSRLQNPAQLPERVEVVLDEFIDSVLGSVDDELENPEIVIDVVLDCSVERFNLDPRLTARALQNLLRNATRYC--DKRI 347
Cdd:COG2205 75 DLSRLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSppGGTI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 348 QVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSrdRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRV 427
Cdd:COG2205 155 TISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNS--RGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTV 232
|
...
gi 516459578 428 WLP 430
Cdd:COG2205 233 TLP 235
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
133-430 |
1.13e-52 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 179.33 E-value: 1.13e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 133 LDMNLLYWSMNVLIGAALLACLLVWLRPHWRDLERLKSTATQLGKGNFGERTRIPPSSNIGSLATVFDTMADDIEHLLNQ 212
Cdd:COG0642 30 LLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 213 QRDLLNAVSHELRTPLTRLDFGLALALSEDLPQASR---------ERLQSLVAHIREldelvlellsYSRLQNPAQLPER 283
Cdd:COG0642 110 KSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREyletilrsaDRLLRLINDLLD----------LSRLEAGKLELEP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 284 VEVVLDEFIDSVLGSVDDELENPEIVIDVVLDCSVERFNLDPRLTARALQNLLRNATRYCDK--RIQVGVKVCPTGCEIC 361
Cdd:COG0642 180 EPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEggTVTVSVRREGDRVRIS 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516459578 362 VDDDGIGIPPDQRERIFEPFYRLDRSrdRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:COG0642 260 VEDTGPGIPPEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
130-430 |
2.11e-46 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 166.26 E-value: 2.11e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 130 PDPLDMNLLYWSMNVLIGAALLAC--LLVWLRphWR---DLERLKSTATQLGKGNFgertRIPPSSNIGSL-----ATVF 199
Cdd:PRK09470 156 PQSDFINLLFDRPLLLLLVTMLVStpLLLWLA--WSlakPARKLKNAADEVAQGNL----RQHPELETGPQefrqaGASF 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 200 DTMADDIEHLLNQQRDLLNAVSHELRTPLTRLDFGLALALSE--DLPQASR-----ERLQSLVAHIreldelvlelLSYS 272
Cdd:PRK09470 230 NQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLRRRqgESKELERieteaQRLDSMINDL----------LVLS 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 273 RLQNPAQLpERVEVVLDEFIDSVLGSVDDELENPEIVIDVVLDcsVERF--NLDPRLTARALQNLLRNATRYCDKRIQVG 350
Cdd:PRK09470 300 RNQQKNHL-ERETFKANSLWSEVLEDAKFEAEQMGKSLTVSAP--PGPWpiNGNPNALASALENIVRNALRYSHTKIEVA 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 351 VKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:PRK09470 377 FSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-430 |
2.00e-39 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 137.18 E-value: 2.00e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 329 ARALQNLLRNATRYCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEA 408
Cdd:cd16939 2 ARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALW 81
|
90 100
....*....|....*....|..
gi 516459578 409 QGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16939 82 HGGHVECDDSELGGACFRLTWP 103
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
145-430 |
8.93e-39 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 145.35 E-value: 8.93e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 145 LIGAA--LLACLLVWL--RPHWRDLERLKSTATQLGKGNFgeRTRIPPSSN--IGSLATVFDTMADDIEHLLNQQRDLLN 218
Cdd:NF012163 168 LIVALalLLAALAAFLlaRGLLAPVKRLVEATHRLAAGDY--TTRVTPTSNdeLGKLAQDFNQLASTLEKNEQMRRDFMA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 219 AVSHELRTPLTRLDFGLAlALSEDLPQASRERLQSLVAHIRELDELVLELLSYSRLQNPAQLPERVEVVLDEFIDSVLGS 298
Cdd:NF012163 246 DISHELRTPLAVLRAELE-AIQDGIRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGA 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 299 VDDELENPEIVIDVVLDCSVERFNlDPRLTARALQNLLRNATRYCDK--RIQVGVKVCPTGCEICVDDDGIGIPPDQRER 376
Cdd:NF012163 325 FRERFASAGLELEVSLPDSSLVFG-DRDRLMQLFNNLLENSLRYTDSggSLHISASQRPKEVTLTVADSAPGVSDEQLAR 403
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 516459578 377 IFEPFYRLDRSRDRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:NF012163 404 LFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
204-430 |
3.27e-37 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 140.48 E-value: 3.27e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 204 DDIEHLLNQQR-----DLLNAVSHELRTPLT-------RLDFGLALALSEDLPQASR---------ERLQSLVAHIReld 262
Cdd:COG5000 187 DDITELLRAERlaawgELARRIAHEIKNPLTpiqlsaeRLRRKLADKLEEDREDLERaldtiirqvDRLKRIVDEFL--- 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 263 elvlellSYSRLQNPaqlpERVEVVLDEFIDSVLGSVDDELENPEIVIDVVLDCSVERFNLDPRLTARALQNLLRNATRY 342
Cdd:COG5000 264 -------DFARLPEP----QLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 343 CDKRIQVGVKVCPTG--CEICVDDDGIGIPPDQRERIFEPFYrldrsrdrST--GGFGLGLAISRRALEAQGGTLTAQAS 418
Cdd:COG5000 333 IEEGGEIEVSTRREDgrVRIEVSDNGPGIPEEVLERIFEPFF--------TTkpKGTGLGLAIVKKIVEEHGGTIELESR 404
|
250
....*....|..
gi 516459578 419 PLGGARFRVWLP 430
Cdd:COG5000 405 PGGGTTFTIRLP 416
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-430 |
4.14e-37 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 130.91 E-value: 4.14e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 329 ARALQNLLRNATRYCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEA 408
Cdd:cd16949 2 ARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIEQ 81
|
90 100
....*....|....*....|..
gi 516459578 409 QGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16949 82 HGGKIKASNRKPGGLRVRIWLP 103
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
132-430 |
1.31e-34 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 133.50 E-value: 1.31e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 132 PLDMNLLywsmnvLIGAALLACLLVWLRPHWRDLERLKSTATQLGKGNFGERTRIPPSSNIGSLATVFDTMADDIEhLLN 211
Cdd:PRK09467 154 PLFRYTL------AIGLLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIK-QLE 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 212 QQRDLLNA-VSHELRTPLTRldfgLALAlSEDLPQASRERLQSLVAHIRELDELVLELLSYSRlqnPAQLPERVEVVLDE 290
Cdd:PRK09467 227 DDRTLLMAgVSHDLRTPLTR----IRLA-TEMMSEEDGYLAESINKDIEECNAIIEQFIDYLR---TGQEMPMEMADLNA 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 291 FIDSVLGSVDDElenpEIVIDVVLDCSVERFNLDPRLTARALQNLLRNATRYCDKRIQVGVKVCPTGCEICVDDDGIGIP 370
Cdd:PRK09467 299 LLGEVIAAESGY----EREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIP 374
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 371 PDQRERIFEPFYRLDRSrdRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:PRK09467 375 PEQLKHLFQPFTRGDSA--RGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLP 432
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
148-434 |
1.70e-34 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 133.60 E-value: 1.70e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 148 AALLACLLVWL--RPHWRDLERLKSTATQLGKGNFGerTRIPPSSN--IGSLATVFDTMADDIEHllNQQ--RDLLNAVS 221
Cdd:PRK10549 173 STLLAALATFLlaRGLLAPVKRLVEGTHKLAAGDFT--TRVTPTSRdeLGRLAQDFNQLASTLEK--NEQmrRDFMADIS 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 222 HELRTPLTRLDFGLAlALSEDLPQASRERLQSLVAHIRELDELVLELLSYSrLQNPAQLPERVEVV-LDEFIDSVLGSVD 300
Cdd:PRK10549 249 HELRTPLAVLRGELE-AIQDGVRKFTPESVASLQAEVGTLTKLVDDLHQLS-LSDEGALAYRKTPVdLVPLLEVAGGAFR 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 301 DELENPEIVIDVVLDCSVERFNlDP-RLTaRALQNLLRNATRYCDK--RIQVGVKVCPTGCEICVDDDGIGIPPDQRERI 377
Cdd:PRK10549 327 ERFASRGLTLQLSLPDSATVFG-DPdRLM-QLFNNLLENSLRYTDSggSLHISAEQRDKTLRLTFADSAPGVSDEQLQKL 404
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 516459578 378 FEPFYRLDRSRDRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLPSVTD 434
Cdd:PRK10549 405 FERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERD 461
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
330-429 |
1.76e-34 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 123.87 E-value: 1.76e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 330 RALQNLLRNATRYC--DKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRstGGFGLGLAISRRALE 407
Cdd:cd00075 3 QVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 516459578 408 AQGGTLTAQASPLGGARFRVWL 429
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
145-434 |
3.18e-33 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 130.92 E-value: 3.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 145 LIGAAL--LACLLVWLRPHW-----RDLERlksTATQLGKGNFGERTRIPPSSNIGSLATVFDTMADDIEHLLNQ----- 212
Cdd:NF040691 192 LGGLALvvLLGLIAWLVTRQvvapvRSAAR---TAERFAAGDLSERMPVKGEDDLARLARSFNQMADSLQRQIRQleels 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 213 --QRDLLNAVSHELRTPLT------------RLDFGLALALSEDLPQASRERLQSLVAHIreldelvlelLSYSRLQNPA 278
Cdd:NF040691 269 rlQQRFVSDVSHELRTPLTtirmaadvihdsRDDFDPATARSAELLHTELDRFESLLSDL----------LEISRFDAGA 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 279 QLPERVEVVLDEFIDSVLGSVDDELENPEIVIDVVLDCSVERFNLDPRLTARALQNLLRNATRYCD-KRIQVGVKVCPTG 357
Cdd:NF040691 339 AELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHGEgKPVVVTVAQDDTA 418
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516459578 358 CEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLPSVTD 434
Cdd:NF040691 419 VAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLPRVAG 495
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
1-430 |
7.26e-33 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 129.91 E-value: 7.26e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 1 MFRVLLRLYLITIVTYSAAIFLIPKLVIQVFEHRYVDYNVEQSRGLQKLIVKQYQRAPVEHWSQVTEQLGRDFAPLKVEL 80
Cdd:COG4251 60 ALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEE 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 81 LLHQDARYTPEEEQLLAQGKPVIRLGEWGWMAEVSAPINPQFAVKLTIPPDPLDMNLLYWSMNVLIGAALLACLLVWLRP 160
Cdd:COG4251 140 LALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 161 HWRDLERLKSTATQLGKGNFGERTRIPPSSNIGSLATVFDTMADDIEHLLNQQRDLLNA----------VSHELRTPLTR 230
Cdd:COG4251 220 SLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSneeleqfayvASHDLREPLRK 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 231 LDfGLALALSEDLP--------------QASRERLQSLVAHIReldelvlellSYSRLQNPAQLPERVEvvLDEFIDSVL 296
Cdd:COG4251 300 IS-GFSQLLEEDYGdkldeegreyleriRDAAERMQALIDDLL----------AYSRVGRQELEFEPVD--LNELLEEVL 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 297 GSVDDELENPEIVIDVVLDCSVErfnLDPRLTARALQNLLRNATRYCDK----RIQVGVKVCPTGCEICVDDDGIGIPPD 372
Cdd:COG4251 367 EDLEPRIEERGAEIEVGPLPTVR---GDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPE 443
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 516459578 373 QRERIFEPFYRLDRSRDRStgGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:COG4251 444 YAEKIFEIFQRLHSRDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
324-430 |
5.34e-32 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 117.75 E-value: 5.34e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 324 DPRLTARALQNLLRNATRYCDKRIQVGVKVCPTG--CEICVDDDGIGIPPDQRERIFEPFYRLDrSRDRSTGGFGLGLAI 401
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGdhVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLSI 80
|
90 100
....*....|....*....|....*....
gi 516459578 402 SRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
154-430 |
1.77e-31 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 123.37 E-value: 1.77e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 154 LLVWLRPHWRDLERLKSTATQLGKGNFGERTRIPPSSNIGSLATVFDTMADDIEHLLNQQRDLLNA------------VS 221
Cdd:COG4191 71 LLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSeklaalgelaagIA 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 222 HELRTPLT----RLDFGLAL----ALSEDLPQASR------ERLQSLVAHIReldelvlellSYSRLQNPaqlpERVEVV 287
Cdd:COG4191 151 HEINNPLAailgNAELLRRRledePDPEELREALErilegaERAAEIVRSLR----------AFSRRDEE----EREPVD 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 288 LDEFIDSVLGSVDDELENPEIVIDVVLDCSVERFNLDPRLTARALQNLLRNA----TRYCDKRIQVGVKVCPTGCEICVD 363
Cdd:COG4191 217 LNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAidamEEGEGGRITISTRREGDYVVISVR 296
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516459578 364 DDGIGIPPDQRERIFEPFYrldrsrdrST----GGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:COG4191 297 DNGPGIPPEVLERIFEPFF--------TTkpvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
205-427 |
3.75e-31 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 121.93 E-value: 3.75e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 205 DIEHLLNQQRDLLNAVSHELRTPLTRLDfG----LALALSEDLPQASR---------ERLQSLVAHIreldelvlelLSY 271
Cdd:TIGR02966 106 RLRRLEQMRRDFVANVSHELRTPLTVLR-GyletLADGPDEDPEEWNRaleimleqsQRMQSLVEDL----------LTL 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 272 SRLQNPAQLPERVEVVLDEFIDSVLGSVDDELENPEIVIDVVLDCSVERFNLDPRLTArALQNLLRNATRYC--DKRIQV 349
Cdd:TIGR02966 175 SRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRS-AFSNLVSNAIKYTpeGGTITV 253
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516459578 350 GVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRV 427
Cdd:TIGR02966 254 RWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSF 331
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
137-430 |
8.16e-31 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 123.27 E-value: 8.16e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 137 LLYWSMNVLIGAALLACLLVWL--RPHWRDLERLKSTATQLGKGNFGerTRIPPS---SNIGSLATVFDTMADDIEHLLN 211
Cdd:TIGR01386 162 LRKWLILIAVLLVLLTALLGWWitRLGLEPLRRLSAVAARISPESLD--QRLDPSrapAELRELAQSFNAMLGRLEDAFQ 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 212 QQRDLLNAVSHELRTPLTRLDFGLALALS--------EDLPQASRERLQSLVAHIRELDELvlellsySRLQNPAQLPER 283
Cdd:TIGR01386 240 RLSQFSADLAHELRTPLTNLLGQTQVALSqprtgeeyREVLESNLEELERLSRMVSDMLFL-------ARADNGQLALER 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 284 VEVVLDEFIDSVLGSVDDELENPEIVIDVVLDCSVErfnLDPRLTARALQNLLRNATRYC--DKRIQVGVKVCPTGCEIC 361
Cdd:TIGR01386 313 VRLDLAAELAKVAEYFEPLAEERGVRIRVEGEGLVR---GDPQMFRRAISNLLSNALRHTpdGGTITVRIERRSDEVRVS 389
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516459578 362 VDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEAQGGTLTAQaSPLGGARFRVWLP 430
Cdd:TIGR01386 390 VSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAE-SPDGKTRFILRFP 457
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-430 |
2.96e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 107.55 E-value: 2.96e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 324 DPRLTARALQNLLRNATRYCDK--RIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAI 401
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 516459578 402 SRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
324-430 |
1.09e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 105.91 E-value: 1.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 324 DPRLTARALQNLLRNATRYCDKRIQVGVKV-CPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRsrdRSTGGFGLGLAIS 402
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLsEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*...
gi 516459578 403 RRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
202-430 |
6.92e-26 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 110.90 E-value: 6.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 202 MADDIEHLLNQqrdLLNAVSHELRTPLTRLdFGLALALSEDL--------PQASRERLQSLvahireldelvlellSYSR 273
Cdd:PRK10490 656 LASEREQLRNA---LLAALSHDLRTPLTVL-FGQAEILTLDLasegsphaRQASEIRQQVL---------------NTTR 716
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 274 LQNPAQLPERVE----------VVLDEFIDSVLGSVDDELENPEIVIDVVLDCSVerFNLDPRLTARALQNLLRNATRYC 343
Cdd:PRK10490 717 LVNNLLDMARIQsggfnlrkewLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTL--IHVDGPLFERVLINLLENAVKYA 794
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 344 DKRIQVGVK--VCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRsrDRSTGGFGLGLAISRRALEAQGGTLTAQASPLG 421
Cdd:PRK10490 795 GAQAEIGIDahVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNK--ESAIPGVGLGLAICRAIVEVHGGTIWAENRPEG 872
|
....*....
gi 516459578 422 GARFRVWLP 430
Cdd:PRK10490 873 GACFRVTLP 881
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-427 |
1.43e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 98.09 E-value: 1.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 332 LQNLLRNATRYCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDrstgGFGLGLAISRRALEAQGG 411
Cdd:cd16954 42 LGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGG 117
|
90
....*....|....*.
gi 516459578 412 TLTAQASPLGGARFRV 427
Cdd:cd16954 118 ELSLSDSPLGGARFEV 133
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
188-430 |
2.26e-24 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 103.39 E-value: 2.26e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 188 PSSNIGSLATVFD-TMADDIEHLLnQQRDLLNAVS-------HELRTPLTrldfGLALA---LSEDLPQASR-------- 248
Cdd:COG3852 103 AEGEGGVLLVLRDiTERKRLEREL-RRAEKLAAVGelaaglaHEIRNPLT----GIRGAaqlLERELPDDELreytqlii 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 249 ---ERLQSLVahireldelvlellsySRLQNPA--QLPERVEVVLDEFIDSVLGSVDDELENpEIVIDVVLDCSVERFNL 323
Cdd:COG3852 178 eeaDRLNNLV----------------DRLLSFSrpRPPEREPVNLHEVLERVLELLRAEAPK-NIRIVRDYDPSLPEVLG 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 324 DP-RLTaRALQNLLRNA-------------TRYcDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYrldrsrd 389
Cdd:COG3852 241 DPdQLI-QVLLNLVRNAaeampeggtitirTRV-ERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF------- 311
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 516459578 390 rST--GGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:COG3852 312 -TTkeKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
136-430 |
1.54e-23 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 102.62 E-value: 1.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 136 NLLYWSMNVLIGAALLACLLVWlrphW--RDLERLKSTATQLGkgnFGERTRIPP--SSNIGSLATVFDTMADDIE---- 207
Cdd:PRK11100 183 RILWAGALLLGIALLIGAGVVW----WlnRSIRRLTRYADAVT---EGKPVPLPKlgSSELRELAQALESMRVKLEgkay 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 208 -----HLLnqqrdllnavSHELRTPLTRLDfGLALALSEDLPQASRE-----------RLQSLVAHIRELdelvlellsy 271
Cdd:PRK11100 256 veqyvQTL----------THELKSPLAAIR-GAAELLQEDPPPEDRArftgniltqsaRLQQLIDRLLEL---------- 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 272 SRLQNPAQLPERVEVVLDEFIDSVLGSVDDELENPEIviDVVLDCSVERFNLDPRLTARALQNLLRNATRYC--DKRIQV 349
Cdd:PRK11100 315 ARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGI--TLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSpeGGTITL 392
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 350 GVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDR--SRDRSTggfGLGLAISRRALEAQGGTLTAQASPLGGARFRV 427
Cdd:PRK11100 393 SAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLPRpaNGRKST---GLGLAFVREVARLHGGEVTLRNRPEGGVLATL 469
|
...
gi 516459578 428 WLP 430
Cdd:PRK11100 470 TLP 472
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-430 |
1.94e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 91.36 E-value: 1.94e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 330 RALQNLLRNATRYCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDrsTGGFGLGLAISRRALEAQ 409
Cdd:cd16950 3 RVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISDAH 80
|
90 100
....*....|....*....|.
gi 516459578 410 GGTLTAQASPLGGARFRVWLP 430
Cdd:cd16950 81 GGSLTLANRAGGGLCARIELP 101
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
209-431 |
1.72e-21 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 95.85 E-value: 1.72e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 209 LLNQQRDLLNAVSHELRTPLTRLDFGLALALSEDLPQASRER-LQSLVAHIRELDELVLELLSYSRLQNPAQ--LPERVE 285
Cdd:PRK11006 200 LEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKaLHTMREQTQRMEGLVKQLLTLSKIEAAPTidLNEKVD 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 286 VVLdefidsVLGSVDDELE-----NPEIVIDVvlDCSVERFNLDPRLTArALQNLLRNATRY--CDKRIQVGVKVCPTGC 358
Cdd:PRK11006 280 VPM------MLRVLEREAQtlsqgKHTITFEV--DNSLKVFGNEDQLRS-AISNLVYNAVNHtpEGTHITVRWQRVPQGA 350
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516459578 359 EICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLPS 431
Cdd:PRK11006 351 EFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
331-430 |
3.48e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 87.77 E-value: 3.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 331 ALQNLLRNATRYCDKR----IQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDrSRDRStGGFGLGLAISRRAL 406
Cdd:cd16921 4 VLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH-SREEY-EGTGVGLAIVRKII 81
|
90 100
....*....|....*....|....
gi 516459578 407 EAQGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16921 82 ERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
332-430 |
6.59e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 87.16 E-value: 6.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 332 LQNLLRNATRYCDK-----RIQVgVKVCPTGCEIC--VDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRR 404
Cdd:cd16922 5 LLNLLGNAIKFTEEgevtlRVSL-EEEEEDGVQLRfsVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKK 83
|
90 100
....*....|....*....|....*.
gi 516459578 405 ALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16922 84 LVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
216-430 |
9.78e-21 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 94.65 E-value: 9.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 216 LLNAVSHELRTPLTRLDFGLALALSEDLPQASRERLQSLVAHIRELDELVLELLSYSRlqnPAQlPERVEVVLDEFIDSV 295
Cdd:PRK11360 393 LVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSR---PRE-SQWQPVSLNALVEEV 468
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 296 LGSVDDELENPEIVIDVVLDCSVERFNLDPRLTARALQNLLRNATRYCDKR--IQVGVKVCPTG-CEICVDDDGIGIPPD 372
Cdd:PRK11360 469 LQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARgkIRIRTWQYSDGqVAVSIEDNGCGIDPE 548
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 516459578 373 QRERIFEPFYRldrSRDRSTGgfgLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:PRK11360 549 LLKKIFDPFFT---TKAKGTG---LGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
324-430 |
1.17e-20 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 86.78 E-value: 1.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 324 DPRLTARALQNLLRNATRYCDK--RIQVGVKVC-PTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLA 400
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDggRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 516459578 401 ISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
184-430 |
1.75e-18 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 87.52 E-value: 1.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 184 TRIPPSS---NIGSLATVFDTMADDIEHLLNQQRDLLNAVSHELRTPLTRLDFGLALALSEDLPQASRER-LQSLVAHIR 259
Cdd:PRK09835 230 VRLDPQTvpiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDvLYSNLEELT 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 260 ELDELVLELLSYSRLQNPAQLPERVEVVLDEFIDSVLGSVDDELENPEIVIDVVLD-CSVERfnlDPRLTARALQNLLRN 338
Cdd:PRK09835 310 RMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDpCQVAG---DPLMLRRAISNLLSN 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 339 ATRYCDK--RIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEAQGGTLTAQ 416
Cdd:PRK09835 387 ALRYTPAgeAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVT 466
|
250
....*....|....
gi 516459578 417 aSPLGGARFRVWLP 430
Cdd:PRK09835 467 -SDARGTRFVISLP 479
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
138-430 |
3.89e-18 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 87.27 E-value: 3.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 138 LYWSMnVLIGAALLA-CLLVWlRPHWRDLERLKSTATQ----LGKGN----FGERTRIPPSSNIGSLATVFDTMAddieH 208
Cdd:PRK11466 330 QYSLL-LLGMVSLCAlILILW-RVVYRSVTRPLAEQTQalqrLLDGDidspFPETAGVRELDTIGRLMDAFRSNV----H 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 209 LLNQQRD------------------------------------LLNAVSHELRTPLTRLdFGLALALSED-LPQASRERL 251
Cdd:PRK11466 404 ALNRHREqlaaqvkartaelqelviehrqaraeaekasqaksaFLAAMSHEIRTPLYGI-LGTAQLLADNpALNAQRDDL 482
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 252 QSLVAHIRELDELVLELLSYSRLQNPAQlpervEVVLDE-------FIDSVLGSVDDELENPEIVIDV-VLDCSVERFNL 323
Cdd:PRK11466 483 RAITDSGESLLTILNDILDYSAIEAGGK-----NVSVSDepfeprpLLESTLQLMSGRVKGRPIRLATdIADDLPTALMG 557
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 324 DPRLTARALQNLLRNATRYCDKriqvGVKVCPTGCE-----ICVDDDGIGIPPDQRERIFEPFYRLDRSRdrstGGFGLG 398
Cdd:PRK11466 558 DPRRIRQVITNLLSNALRFTDE----GSIVLRSRTDgeqwlVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLG 629
|
330 340 350
....*....|....*....|....*....|..
gi 516459578 399 LAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:PRK11466 630 LTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
220-430 |
1.44e-17 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 84.45 E-value: 1.44e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 220 VSHELRTPLTRLDfGLALALSEDLPQASRERLQSLVAhIRELDELVLELLSYSRLQNPAQLPERvEVVLDEFIDSVLGSV 299
Cdd:PRK10364 244 VAHEIRNPLSSIK-GLAKYFAERAPAGGEAHQLAQVM-AKEADRLNRVVSELLELVKPTHLALQ-AVDLNDLINHSLQLV 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 300 DDELENPEIVIDVVLDCSVERFNLDPRLTARALQNLLRNATRYCDK--RIQVGVKVCPTGCEICVDDDGIGIPPDQRERI 377
Cdd:PRK10364 321 SQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQhgVISVTASESGAGVKISVTDSGKGIAADQLEAI 400
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 516459578 378 FEPFYrldrsrDRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:PRK10364 401 FTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-429 |
1.89e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 77.83 E-value: 1.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 324 DPRLTARALQNLLRNATRYCDKRIQVGVKV-CPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRsrdRSTGGFGLGLAIS 402
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLsADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIV 86
|
90 100
....*....|....*....|....*..
gi 516459578 403 RRALEAQGGTLTAQASPLGGARFRVWL 429
Cdd:cd16940 87 KRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
289-430 |
3.87e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 82.59 E-value: 3.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 289 DEFIDSVLGSVDDELENPEIVIDVVLDCSVERFNLDPRLTARALQNLLRNATRYC------DKRIQVGVKVCPTGCEICV 362
Cdd:COG3290 243 NPVLAALLLGKAARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVeklpeeERRVELSIRDDGDELVIEV 322
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516459578 363 DDDGIGIPPDQRERIFEPFYRLDRSRDRstggfGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:COG3290 323 EDSGPGIPEELLEKIFERGFSTKLGEGR-----GLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-430 |
4.38e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 76.27 E-value: 4.38e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 328 TARALQNLLRNATRYCDKRIQVGVKVCPTG--CEICVDDDGIGIPPDQRERIFEPFYRLDRSRDrsTGGFGLGLAISRRA 405
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDdvVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 516459578 406 LEAQGGTLTAQaSPLGGARFRVWLP 430
Cdd:cd16923 79 IELHGGSASAE-YDDNHDLFKVRLP 102
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
168-430 |
4.67e-17 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 81.96 E-value: 4.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 168 LKSTATQLGKGNFGERTRIPP--SSNIGSLATVFDTMADDIE-HLLNQQrdLLNA-VSHELRTPLT----RLD------F 233
Cdd:NF012226 91 LADAAKKISQGDLSARAEDSQihSAEISELMHNFNDMAQKLEsSVKNAQ--VWNAaIAHELRTPITilqgRLQgildgvF 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 234 GLALALSED-LPQAsrERLQSLVAHIReldelvlellSYSRLQNpAQLPERVEVV-LDEFIDSVLGSVDDELENPEIVId 311
Cdd:NF012226 169 EPDPALFKSlLNQV--EGLSHLVEDLR----------TLSLVEN-QQLRLNYESVdLKDSIEKVLKMFEDRLEQAQLTI- 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 312 vVLDCSVERFNLDPRLTARALQNLLRNATRYCDK-RIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDR 390
Cdd:NF012226 235 -VLNLTATPVFCDRRRIEQVLIALIDNAIRYANAgKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNK 313
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 516459578 391 STGGFGLGLAISRRALEAQGGTLTAQaSPLGGARFRVWLP 430
Cdd:NF012226 314 EFGGTGLGLAVVHAIVIAHKGSIEYS-NSQGNSVFTIKLP 352
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
331-431 |
1.26e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 75.32 E-value: 1.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 331 ALQNLLRNATRYCDKRIQVGVK--VCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEA 408
Cdd:cd16952 4 AFSNLVSNAVKYTPPSDTITVRwsQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSR 83
|
90 100
....*....|....*....|...
gi 516459578 409 QGGTLTAQASPLGGARFRVWLPS 431
Cdd:cd16952 84 HDARLLIASELGKGSRFTCLFPS 106
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-430 |
2.59e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 74.36 E-value: 2.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 332 LQNLLRNATR-----YCDKRiQVGVKVCPTG---CEICVDDDGIGIPPDQRERIFEPFYRLDRSrdrstgGFGLGLAISR 403
Cdd:cd16920 5 LINLVRNGIEamsegGCERR-ELTIRTSPADdraVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSICR 77
|
90 100
....*....|....*....|....*..
gi 516459578 404 RALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16920 78 SIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-430 |
1.37e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 72.07 E-value: 1.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 325 PRLTARALQNLLRNATRYCDKRIQVGVKVCPTGCE--ICVDDDGIGIPPDQRERIFEPFYRLDRSRDrstgGFGLGLAIS 402
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQvlIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100
....*....|....*....|....*...
gi 516459578 403 RRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
217-430 |
1.74e-15 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 79.05 E-value: 1.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 217 LNAVSHELRTPLTRLDFGLALALSEDLPQASRERLQSLVAHIRELDELVLELLSYSRLQ--NPAQLPERVEvvLDEFIDS 294
Cdd:TIGR02956 468 LATMSHEIRTPLNGILGTLELLGDTGLTSQQQQYLQVINRSGESLLDILNDILDYSKIEagHLSISPRPFD--LNALLDD 545
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 295 VLGSVDDELENPEIVIDVVLDCSVERF-NLDPRLTARALQNLLRNATRYCDK---RIQVGVKVcPTGCEICVDDDGIGIP 370
Cdd:TIGR02956 546 VHHLMVSRAQLKGIQLRLNIPEQLPNWwQGDGPRIRQVLINLVGNAIKFTDRgsvVLRVSLND-DSSLLFEVEDTGCGIA 624
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 371 PDQRERIFEPFYRLDRSrdRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:TIGR02956 625 EEEQATLFDAFTQADGR--RRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
334-427 |
2.28e-15 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 77.75 E-value: 2.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 334 NLLRNATRYCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDrstgGFGLGLAISRRALEAQGGTL 413
Cdd:PRK10815 385 NVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKI 460
|
90
....*....|....
gi 516459578 414 TAQASPLGGARFRV 427
Cdd:PRK10815 461 SAGDSPLGGARMEV 474
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
208-434 |
3.64e-15 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 76.55 E-value: 3.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 208 HLLNQQRDLLNAVSHELRTPLTrldfGLALALsEDLPQASRERLQSLVAHIRELDELVLELLSYSRLQN--PAQLPERVE 285
Cdd:PRK10755 132 STLDQERLFTADVAHELRTPLA----GIRLHL-ELLEKQHHIDVAPLIARLDQMMHTVEQLLQLARAGQsfSSGHYQTVK 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 286 VVlDEFIDSVLGSVDDELENPEIVIDVVLDCSVERFNLDPRLTARALQNLLRNATRYCDK--RIQVGVKVCPTGCEICVD 363
Cdd:PRK10755 207 LL-EDVILPSQDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEgsTITIKLSQEDGGAVLAVE 285
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516459578 364 DDGIGIPPDQRERIFEPFYRLdrsrDRSTGGFGLGLAISRRALEAQGGTLTAQ-ASPLGGARFRVWLPSVTD 434
Cdd:PRK10755 286 DEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSIVSRITQLHHGQFFLQnRQERSGTRAWVWLPKAQN 353
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
144-430 |
2.73e-14 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 73.83 E-value: 2.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 144 VLIGAALLACLLVWLrPHWrdlERLKSTATQLGKGnfgERTRIPPSsniGSLATVFDTMADDI-------EHLLNQ---Q 213
Cdd:PRK09303 82 VLAGSNIFQQLKNWW-PRW---QQEGATYSGLGEN---LQPSEIDS---GRYSQELLQLSDELfvlrqenETLLEQlkfK 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 214 RDLLNAVSHELRTPLTrldfGLALAL----------SEDLPQASRERLQSlvaHIReldelvlellsySRLQNPAQL--- 280
Cdd:PRK09303 152 DRVLAMLAHDLRTPLT----AASLALetlelgqideDTELKPALIEQLQD---QAR------------RQLEEIERLitd 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 281 ---------------PERVEV------VLDEFIDSVLGsvddelENPEIVIDVVLDcsVERFNLDPRLTARALQNLLRNA 339
Cdd:PRK09303 213 llevgrtrwealrfnPQKLDLgslcqeVILELEKRWLA------KSLEIQTDIPSD--LPSVYADQERIRQVLLNLLDNA 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 340 TRYCDK--RIQVGV------KVcptgcEICVDDDGIGIPPDQRERIFEPFYRLDrsRDRSTGGFGLGLAISRRALEAQGG 411
Cdd:PRK09303 285 IKYTPEggTITLSMlhrttqKV-----QVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYG 357
|
330
....*....|....*....
gi 516459578 412 TLTAQASPLGGARFRVWLP 430
Cdd:PRK09303 358 QIWVDSEPGQGSCFHFTLP 376
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
136-422 |
3.48e-14 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 73.92 E-value: 3.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 136 NLLYWsmnvLIGAALLACLLVWLRphWRDLERLKSTATQLgkgnfgeRTRIPPSSN--------------IGSLATVFDT 201
Cdd:PRK10337 163 QLIPW----LVALPIMLIILMVLL--GRELAPLKKLALAL-------RMRDPDSETplnatgvpsevrplVEALNQLFAR 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 202 MADdiehLLNQQRDLLNAVSHELRTPLTRLDFGLALA-LSEDLPQASRERLQSLVAHIRELDELVLELLSYSRLQNPAQL 280
Cdd:PRK10337 230 THA----MMVRERRFTSDAAHELRSPLAALKVQTEVAqLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNL 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 281 PERVEVVLDEFIDSVLGSVDDELENPEIVIDVVLDCSVERFNLDPRLTARALQNLLRNATRYCDKRIQVGVKVCPTgcEI 360
Cdd:PRK10337 306 QDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR--NF 383
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516459578 361 CVDDDGIGIPPDQRERIFEPFYrldRSRDRSTGGFGLGLAISRRALEAQGGTLTAQASPLGG 422
Cdd:PRK10337 384 TVRDNGPGVTPEALARIGERFY---RPPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-430 |
4.19e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 68.37 E-value: 4.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 330 RALQNLLRNATRYC-DKRIQVGVKVCPTG--CEICVDDDGIGIPPDQRERIFEPFYRlDRSRDRSTGGF-GLGLAISRRA 405
Cdd:cd16953 3 QVLRNLIGNAISFSpPDTGRITVSAMPTGkmVTISVEDEGPGIPQEKLESIFDRFYT-ERPANEAFGQHsGLGLSISRQI 81
|
90 100
....*....|....*....|....*....
gi 516459578 406 LEAQGGTLTA----QASPLGGARFRVWLP 430
Cdd:cd16953 82 IEAHGGISVAenhnQPGQVIGARFTVQLP 110
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-430 |
1.07e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 67.18 E-value: 1.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 324 DPRLTARALQNLLRNATRYCDKR----IQVGVKVCPTGCE---ICVDDDGIGIPPDQRERIFEPfYRLDRSRdrstgGFG 396
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRpsdvGEVRIRVEADQDGrivLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 516459578 397 LGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-419 |
6.40e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 65.23 E-value: 6.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 330 RALQNLLRNATRYCD--KRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALE 407
Cdd:cd16947 23 RILKNLISNAIKYGSdgKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTITKRLAE 102
|
90
....*....|..
gi 516459578 408 AQGGTLTAQASP 419
Cdd:cd16947 103 SMGGSIYVNSKP 114
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
332-433 |
3.40e-12 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 68.55 E-value: 3.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 332 LQNLLRNATRYCDKRIQVGVKV---------------CPTG--CEICVDDDGIGIPPDQRERIFEPFYRlDRSrdrstGG 394
Cdd:PRK13837 565 LMNLCSNAAQAMDGAGRVDISLsraklrapkvlshgvLPPGryVLLRVSDTGAGIDEAVLPHIFEPFFT-TRA-----GG 638
|
90 100 110
....*....|....*....|....*....|....*....
gi 516459578 395 FGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLPSVT 433
Cdd:PRK13837 639 TGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSS 677
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-428 |
2.66e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 60.17 E-value: 2.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 324 DPRLTARALQNLLRNATRYCDKRIQVGVKVCptgCE-----ICVDDDGIGIPPDQRERIFEPFYRLDRSRDrSTGGFGLG 398
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIY---DEeeylyFEIWDNGHGFSEQDLKKALELFYRDDTSRR-SGGHYGMG 76
|
90 100 110
....*....|....*....|....*....|
gi 516459578 399 LAISRRALEAQGGTLTAQASPLGGARFRVW 428
Cdd:cd16975 77 LYIAKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
145-430 |
7.44e-11 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 63.99 E-value: 7.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 145 LIGAALLACLLVWLRPHWRdLERLKSTATQL--GKGNFgeRTRIPPSS---NIGSLATVFDTMADDIEHLLNQQRDLLNA 219
Cdd:TIGR03785 415 IMSIGTLALFGFASWISWR-IRRLSDDAEAAidSQGRI--SGAIPASRsrdEIGDLSRSFAQMVARLRQYTHYLENMSSR 491
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 220 VSHELRTPL----TRLDfGLALALSEDLPQASRERLQSLVAHIRELDELVLELlsySRLQNPAQLPERVEVVLDEFIDS- 294
Cdd:TIGR03785 492 LSHELRTPVavvrSSLE-NLELQALEQEKQKYLERAREGTERLSMILNNMSEA---TRLEQAIQSAEVEDFDLSEVLSGc 567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 295 ------VLGSVDDELENPEivIDVVLDCSverfnldPRLTARALQNLLRNATRYC--DKRIQVGVKVCPTGCEICVDDDG 366
Cdd:TIGR03785 568 mqgyqmTYPPQRFELNIPE--TPLVMRGS-------PELIAQMLDKLVDNAREFSpeDGLIEVGLSQNKSHALLTVSNEG 638
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516459578 367 IGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEAQGGTLTAQASPLG-GARFRVWLP 430
Cdd:TIGR03785 639 PPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNdGVVFRISLP 703
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
2-430 |
9.11e-11 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 63.50 E-value: 9.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 2 FRVLLRLYLITIVTYSAAIFLIPKLVIQVFEHRYVDYNVEQSRGLQKLIVKQYQRAPVEHWSQVTEQLGRDFAPLKVELL 81
Cdd:COG2972 29 LLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLLLALILL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 82 LHQDARYTPEEEQLLAQGKPVIRLGEWGWMAEVSAPINPQFAVKLTIppdpldMNLLYWSMNVLIGAALLACLLVWLRPH 161
Cdd:COG2972 109 LALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSL------RRLILLIILLLLLLALLLSYLLSRSIT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 162 wRDLERLKSTATQLGKGNFgerTRIPPSSN--IGSLATVFDTMADDIEHLLNQQRDLLNAVSH-ELR------------- 225
Cdd:COG2972 183 -RPIKRLKKAMKKVEKGDL---VRLEVSGNdeIGILARSFNEMVERIKELIEEVYELELEKKEaELKalqaqinphflfn 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 226 TpltrLDFGLALALSEDLPQASR----------------ERLQSL---VAHIReldelvlellSYSRLQNpAQLPERVEV 286
Cdd:COG2972 259 T----LNSIRWLAELEDPEEAEEmlealskllryslskgDELVTLeeeLELIK----------SYLEIQK-LRFGDRLEV 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 287 VLDefidsvlgsVDDELENpeividvvldcsverfNLDPRLTaraLQNLLRNATRY------CDKRIQVGVKVCPTGCEI 360
Cdd:COG2972 324 EIE---------IDEELLD----------------LLIPKLI---LQPLVENAIEHgiepkeGGGTIRISIRKEGDRLVI 375
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516459578 361 CVDDDGIGIPPDQRERIFEPFyrldrSRDRSTGGFGLGLAISR-RALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:COG2972 376 TVEDNGVGMPEEKLEKLLEEL-----SSKGEGRGIGLRNVRERlKLYYGEEYGLEIESEPGEGTTVTIRIP 441
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-429 |
9.95e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 58.24 E-value: 9.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 332 LQNLLRNAT----RYCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRldrsrDRSTG-GFGLGLAISRRAL 406
Cdd:cd16976 5 LMNLLQNALdamgKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYGIV 79
|
90 100
....*....|....*....|...
gi 516459578 407 EAQGGTLTAQASPLGGARFRVWL 429
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTFDL 102
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
334-432 |
1.17e-10 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 63.21 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 334 NLLRNATRYCDK--RIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSrdrstgGFGLGLAISRRALEAQGG 411
Cdd:COG5805 402 NLIKNAIEAMPNggTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNG 475
|
90 100
....*....|....*....|.
gi 516459578 412 TLTAQASPLGGARFRVWLPSV 432
Cdd:COG5805 476 TIDIDSKVGKGTTFTITLPLS 496
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-430 |
1.43e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 58.07 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 334 NLLRNA------TRYCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRldrsrDRSTGGFGLGLAISRRALE 407
Cdd:cd16915 7 NLIDNAldalaaTGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 516459578 408 AQGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
217-430 |
1.51e-10 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 63.51 E-value: 1.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 217 LNAVSHELRTPLTrldfGL--ALALSE---------DLPQASRERLQSLVAHIRELDelvlellSYSRLQNpAQL---PE 282
Cdd:PRK15347 402 LTTISHEIRTPLN----GVlgALELLQntpltaeqmDLADTARQCTLSLLAIINNLL-------DFSRIES-GQMtlsLE 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 283 RVEVVLdeFIDSVLGSVDDELENPEIVIDVVLDCSV-ERFNLDPRLTARALQNLLRNATRYCDK-RIQVGVKVCPTGCEI 360
Cdd:PRK15347 470 ETALLP--LLDQAMLTIQGPAQSKSLTLRTFVGAHVpLYLHLDSLRLRQILVNLLGNAVKFTETgGIRLRVKRHEQQLCF 547
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 361 CVDDDGIGIPPDQRERIFEPFYRLDRSRdrstGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:PRK15347 548 TVEDTGCGIDIQQQQQIFTPFYQADTHS----QGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-422 |
2.02e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 57.47 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 324 DPRLTARALQNLLRNATRYCDK--RIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDR--SRDRSTggfGLGL 399
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEggLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRphSGQKST---GLGL 77
|
90 100
....*....|....*....|...
gi 516459578 400 AISRRALEAQGGTLTAQASPLGG 422
Cdd:cd16945 78 AFVQEVAQLHGGRITLRNRPDGV 100
|
|
| ActS_PrrB_HisK |
NF033792 |
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ... |
219-428 |
9.00e-10 |
|
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.
Pssm-ID: 468186 [Multi-domain] Cd Length: 423 Bit Score: 60.22 E-value: 9.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 219 AVSHELRTPL-TrldfgLALA---LSEDLPQAS--RERLQSLVA------HIreldelvlellsysrLQNPAQLPERVEV 286
Cdd:NF033792 208 AAAHELGTPLaT-----IALVakeLERELPDDPplREDAELLRSqaercrDI---------------LRRLTSLGEEGDA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 287 VLDEF-IDSVLGSVDDELENPEIVIDVVLDCSVERfnlDPRLTAR-----ALQNLLRNATRYCDKRIQVGVKVCPTGCEI 360
Cdd:NF033792 268 HLDRLpLSALIEEAAAPHRGFGKEIEVVVAGDPGE---EPVIRRNpeilyGLGNLIENAVDFARSTVTVTASWDAESVTI 344
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516459578 361 CVDDDGIGIPPDQRERIFEPFYRLDRSRDRST--GGFGLGLAISRRALEAQGGTLTAQ--ASPLGGARFRV-W 428
Cdd:NF033792 345 TIEDDGPGFPPDVLSRIGEPYVTTRRGEERRPggGGLGLGLFIAKTLLERSGATVTFAnrPPPEGGAVVTVrW 417
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
332-430 |
9.06e-10 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 60.72 E-value: 9.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 332 LQNLLRNATRYCDK-RIQVGVkVCPTGCEIC--VDDDGIGIPPDQRERIFEPFYRLDRSRD-RSTGGFGLGLAISRRALE 407
Cdd:PRK11091 403 LWNLISNAVKFTQQgGVTVRV-RYEEGDMLTfeVEDSGIGIPEDELDKIFAMYYQVKDSHGgKPATGTGIGLAVSKRLAQ 481
|
90 100
....*....|....*....|...
gi 516459578 408 AQGGTLTAQASPLGGARFRVWLP 430
Cdd:PRK11091 482 AMGGDITVTSEEGKGSCFTLTIH 504
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-430 |
2.39e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 54.71 E-value: 2.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 330 RALQNLLRNATRYCDK---------RIQVGVKVCPTG----CEICVDDDGIGIPPDQRERIFEPFYrldRSRDrstGGFG 396
Cdd:cd16918 3 QVFLNLVRNAAQALAGsggeiilrtRTQRQVTLGHPRhrlaLRVSVIDNGPGIPPDLQDTIFYPMV---SGRE---NGTG 76
|
90 100 110
....*....|....*....|....*....|....
gi 516459578 397 LGLAISRRALEAQGGTLTAQASPlGGARFRVWLP 430
Cdd:cd16918 77 LGLAIAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
360-430 |
4.73e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 53.92 E-value: 4.73e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516459578 360 ICVDDDGIGIPPDQRERIFEPFYrldrsRDRSTG-GFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16919 50 LEVSDTGSGMPAEVLRRAFEPFF-----TTKEVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
310-430 |
2.02e-08 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 55.01 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 310 IDVVLDCSVERFNLDPRLTA---RALQNLLRNATRYCD-KRIQVGVKVCPTGCEICVDDDGIGIPPDQRERifepfyrld 385
Cdd:COG4585 142 IRVELDVDGDPDRLPPEVELalyRIVQEALTNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPEAAPG--------- 212
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 516459578 386 rsrdrstGGFGLgLAISRRAlEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:COG4585 213 -------GGLGL-RGMRERA-EALGGTLTIGSAPGGGTRVRATLP 248
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
212-430 |
3.04e-08 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 55.09 E-value: 3.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 212 QQ---RDLLNAVSHELRTPLTRLDfGLALALSEDLP-------------QAsrERLQSLVahireldelvlellsySRLQ 275
Cdd:PRK11073 126 QQvaaRDLVRGLAHEIKNPLGGLR-GAAQLLSKALPdpalteytkviieQA--DRLRNLV----------------DRLL 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 276 NPAQLPERVEVVLDEFIDSVLGSVddELENPE-IVIDVVLDCSVERFNLDPRLTARALQNLLRNA--------------T 340
Cdd:PRK11073 187 GPQRPGTHVTESIHKVAERVVQLV--SLELPDnVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNAlqalgpeggtitlrT 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 341 RyCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIfepFYRLDRSRDrstGGFGLGLAISRRALEAQGGTLTAQASPl 420
Cdd:PRK11073 265 R-TAFQLTLHGERYRLAARIDIEDNGPGIPPHLQDTL---FYPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWP- 336
|
250
....*....|
gi 516459578 421 GGARFRVWLP 430
Cdd:PRK11073 337 GHTEFSVYLP 346
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
334-434 |
4.75e-08 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 54.98 E-value: 4.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 334 NLLRNATRYCDK----RIQVGVKVCpTGCEICVDDDGIGIPPDQRERIFEPFYrldrsrdrST--GGFGLGLAISRRALE 407
Cdd:COG5809 386 NLLKNAIEAMPEggniTIETKAEDD-DKVVISVTDEGCGIPEERLKKLGEPFY--------TTkeKGTGLGLMVSYKIIE 456
|
90 100
....*....|....*....|....*..
gi 516459578 408 AQGGTLTAQASPLGGARFRVWLPSVTD 434
Cdd:COG5809 457 EHGGKITVESEVGKGTTFSITLPIKLS 483
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
324-430 |
2.48e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 53.05 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 324 DPRLTARALQNLLRNATRYCDkriqvgvkvcpTGC------------EICVDDDGIGIPPDQRERIFEPFYRLDRSRDRS 391
Cdd:PRK10841 559 DPMRLQQVISNLLSNAIKFTD-----------TGCivlhvrvdgdylSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRN 627
|
90 100 110
....*....|....*....|....*....|....*....
gi 516459578 392 TGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:PRK10841 628 FQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
331-430 |
5.12e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 48.05 E-value: 5.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 331 ALQNLLRNATRYCDK--RIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFY--RLDRSRDRSTggfGLGLAISRRAL 406
Cdd:cd16948 9 IIGQIVSNALKYSKQggKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFtgENGRNFQEST---GMGLYLVKKLC 85
|
90 100
....*....|....*....|....
gi 516459578 407 EAQGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITFP 109
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
219-432 |
9.59e-07 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 50.64 E-value: 9.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 219 AVSHELRTPLTRLDFGLALALSEDLPQASRERLQSLV--------AHIReldelvlellSYSRLQNPAqlPERVEVVlde 290
Cdd:COG5806 207 SIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIAleeldraeAIIT----------DYLTFAKPQ--PEKLEKI--- 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 291 fidsvlgSVDDELENpeiVIDVVLDC----SVE-RFNLDPRLTA--------RALQNLLRNATRYCDK--RIQVGVKVCP 355
Cdd:COG5806 272 -------DVSEELEH---VIDVLSPYanmnNVEiQTELEPGLYIegdrqklqQCLINIIKNGIEAMPNggTLTIDVSIDK 341
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516459578 356 TGCEICVDDDGIGIPPDQRERIFEPFYrldrsrdrST--GGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLPSV 432
Cdd:COG5806 342 NKVIISIKDTGVGMTKEQLERLGEPYF--------STkeKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPLA 412
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
358-430 |
2.38e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 49.85 E-value: 2.38e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516459578 358 CEICvdDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:PRK11107 447 VQIR--DTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-424 |
1.06e-05 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 47.80 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 1 MFRVLLRLYLITIVTYSAAIFLIPKLVIQVFEHRYVDYNVEQSRGLQKLIVKQYQRAPVEHWSQVTEQLGRDFAPLKVEL 80
Cdd:COG2770 74 ALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLL 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 81 LLHQDARYTPEEEQLLAQGKPVIRLGEWGWMAEVSAPINPQFAVKLTIPPDPLDMNLLYWSMNVLIGAALLACLLVWLRP 160
Cdd:COG2770 154 LAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLA 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 161 HW--RDLERLKSTATQLGKGNFGERTRIPPSSNIGSLATVFDTMADDIEHLLNQQRDLLNAVSHELRTPLTRLDFGLALA 238
Cdd:COG2770 234 RRitRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLAL 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 239 LSEDLPQASRERLQSLVAHIRELDELVLELLSYSRLQNPAQLPERVEVVLDEFIDSVLGSVDDELENPEIVIDVVLDCSV 318
Cdd:COG2770 314 LLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLA 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 319 ERFNLDPRLTARALQNLLRNATRYCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGGFGLG 398
Cdd:COG2770 394 LLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALL 473
|
410 420
....*....|....*....|....*.
gi 516459578 399 LAISRRALEAQGGTLTAQASPLGGAR 424
Cdd:COG2770 474 LLAALLLLAALGALELLLLEEEEEAG 499
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
298-400 |
1.17e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 44.52 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 298 SVDDELENPEIVIDVVLDCsVERFNLDPRLTAR---ALQNLLRNATRY-----CDKRIQVGVKVCPTGCEICVDDDGIGI 369
Cdd:COG2172 3 SLPADLEDLGLARRAVRAL-LRELGLDEDDADDlvlAVSEAVTNAVRHayggdPDGPVEVELELDPDGLEIEVRDEGPGF 81
|
90 100 110
....*....|....*....|....*....|.
gi 516459578 370 PPDQRErifepfyrlDRSRDRSTGGFGLGLA 400
Cdd:COG2172 82 DPEDLP---------DPYSTLAEGGRGLFLI 103
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
163-206 |
2.30e-05 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 41.28 E-value: 2.30e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 516459578 163 RDLERLKSTATQLGKGNFgeRTRIPPSSN--IGSLATVFDTMADDI 206
Cdd:cd06225 2 RPLRRLTEAARRIAEGDL--DVRVPVRSKdeIGELARAFNQMAERL 45
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
332-430 |
2.47e-05 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 46.44 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 332 LQNLLRNA----TRYCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEPFYrldrsrdrSTGG--FGLGLAISRRA 405
Cdd:PRK11086 438 LGNLIENAleavGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY--------STKGsnRGVGLYLVKQS 509
|
90 100
....*....|....*....|....*
gi 516459578 406 LEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:PRK11086 510 VENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
235-434 |
2.61e-05 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 46.59 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 235 LALALSEdlPQASRERLQSLVAHIRELDELVLELL----SYSRLQnpaQLPERVeVVLDEFIDSVLGSVDDELeNPEIVI 310
Cdd:PRK13557 188 IQAALSH--PDADRGRMARSVENIRAAAERAATLTqqllAFARKQ---RLEGRV-LNLNGLVSGMGELAERTL-GDAVTI 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 311 DVVLDCSVERFNLDPRLTARALQNLLRNA-------------TRYCDKRIQ--VGVKVCPTGC--EICVDDDGIGIPPDQ 373
Cdd:PRK13557 261 ETDLAPDLWNCRIDPTQAEVALLNVLINArdampeggrvtirTRNVEIEDEdlAMYHGLPPGRyvSIAVTDTGSGMPPEI 340
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516459578 374 RERIFEPFYrldRSRDRSTGGfGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLPSVTD 434
Cdd:PRK13557 341 LARVMDPFF---TTKEEGKGT-GLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQ 397
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
71-339 |
4.97e-05 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 45.64 E-value: 4.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 71 RDFAPLKVELLLHQDARYTPEEEQLLAQGKPVIRLGEWGWMAEVSAPINPQFAVKLTIPPDPLDMNLLYWSMNVLIGAAL 150
Cdd:COG3850 50 ASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 151 LACLLVWLRPHW--RDLERLKSTATQLGKGNFGERTRIPPSSNIGSLATVFDTMADDIEHL---LNQQRDLLNAVSHELR 225
Cdd:COG3850 130 LALLLAYLLRRRivRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELyaeLEEEEELEAELELLAL 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 226 TPLTRLDFGLALALSEDLPQASRERLQSLVAHIRELDELVLELLSYSRLQNPAQLPERVEVVLDEFIDSVLGSVDDELEN 305
Cdd:COG3850 210 LDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALL 289
|
250 260 270
....*....|....*....|....*....|....
gi 516459578 306 PEIVIDVVLDCSVERFNLDPRLTARALQNLLRNA 339
Cdd:COG3850 290 LELVELLALAAAEEALLLLVELAALLLLLLLQAI 323
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
212-259 |
7.54e-05 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 40.66 E-value: 7.54e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 516459578 212 QQRDLLNAVSHELRTPLTRLDFGLALALSEDLPQASRERLQSLVAHIR 259
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAE 48
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
360-430 |
7.74e-05 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 44.89 E-value: 7.74e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516459578 360 ICVDDDGIGIPPDQRERIFEPFYrldRSRDRSTGGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:TIGR02938 426 VSILDSGPGIPQDLRYKVFEPFF---TTKGGSRKHIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFR 493
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
212-259 |
1.10e-04 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 40.24 E-value: 1.10e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 516459578 212 QQRDLLNAVSHELRTPLTRLDFGLALALSEDLPQASRERLQSLVAHIR 259
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAE 48
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
159-211 |
2.39e-04 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 38.77 E-value: 2.39e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 516459578 159 RPHWRDLERLKSTATQLGKGNFgeRTRIPPSSN--IGSLATVFDTMADDIEHLLN 211
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDL--TVRLPVDGRdeIGELARAFNEMADRLEETIA 53
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
288-430 |
2.82e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 42.97 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 288 LDEFIDSVLGSVDDELENPEIVIDVvldcSVERFNLDPRLT---ARALQNLLRNATRYCDK-----RIQVGVKVCPTGCE 359
Cdd:COG3920 361 LRDYLRELLEPLRDSYGGRGIRIEL----DGPDVELPADAAvplGLILNELVTNALKHAFLsgeggRIRVSWRREDGRLR 436
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516459578 360 ICVDDDGIGIPPDqreriFEPfyrldrsrdRSTGGFGLGLAisRRALEAQGGTLTAQASPlgGARFRVWLP 430
Cdd:COG3920 437 LTVSDNGVGLPED-----VDP---------PARKGLGLRLI--RALVRQLGGTLELDRPE--GTRVRITFP 489
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-430 |
5.01e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 38.69 E-value: 5.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 330 RALQNLLRNATRYCD-KRIQVGVKVCPTGCEICVDDDGIGIPPDQRErifepfyrldrsrdrstGGFGLGLAISRRALEA 408
Cdd:cd16917 3 RIVQEALTNALKHAGaSRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAEL 65
|
90 100
....*....|....*....|..
gi 516459578 409 QGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16917 66 LGGTLTIGSRPGGGTRVTARLP 87
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
322-432 |
5.76e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 42.13 E-value: 5.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 322 NLDPRLTARALQNLLRNA------TRYCDKRIQVGVKVCPTGCEICVDDDGIGIPPDQRERIFEpfyRLDRSRDRSTGGF 395
Cdd:PRK15053 427 GLDSTEFAAIVGNLLDNAfeaslrSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFE---QGVSTRADEPGEH 503
|
90 100 110
....*....|....*....|....*....|....*..
gi 516459578 396 GLGLAISRRALEAQGGTLTAQASPLGGARFRVWLPSV 432
Cdd:PRK15053 504 GIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKV 540
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
210-251 |
7.05e-04 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 37.96 E-value: 7.05e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 516459578 210 LNQQRDLLNAVSHELRTPLTRLDFGLALALSEDLPQASRERL 251
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREY 42
|
|
| HAMP |
pfam00672 |
HAMP domain; |
159-208 |
1.98e-03 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 36.06 E-value: 1.98e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 516459578 159 RPHWRDLERLKSTATQLGKGNFGERTRIPPSSNIGSLATVFDTMADDIEH 208
Cdd:pfam00672 4 RRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
201-430 |
1.98e-03 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 40.87 E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 201 TMADDIEHLLNQQRD-----------LLNAVSHELRTPLTRLDFGLALALSEDLPQASRERL--------QSLVAHIREL 261
Cdd:PRK09959 689 TETRDLIHALEVERNkainatvaksqFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAislayatgQSLLGLIGEI 768
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 262 DELVLELLSYSRLQNP-AQLPERVEVVLDEFiDSVLGSVDDELENPEIVIDVVLdcsverFNLDPRLTARALQNLLRNAT 340
Cdd:PRK09959 769 LDVDKIESGNYQLQPQwVDIPTLVQNTCHSF-GAIAASKSIALSCSSTFPDHYL------VKIDPQAFKQVLSNLLSNAL 841
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 341 RYCdkrIQVGVKVCPTGCEI---------CVDDDGIGIPPDQRERIFEPFYRLDRSRDRSTGgfGLGLAISRRALEAQGG 411
Cdd:PRK09959 842 KFT---TEGAVKITTSLGHIddnhavikmTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGS--GLGLMICKELIKNMQG 916
|
250
....*....|....*....
gi 516459578 412 TLTAQASPLGGARFRVWLP 430
Cdd:PRK09959 917 DLSLESHPGIGTTFTITIP 935
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
335-430 |
3.19e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 38.09 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 335 LLRNATR--------YCDKRIQVGVKVCpTGCE---ICVDDDGIGIPPDQRERIF------------EPFYRLDRSRDRS 391
Cdd:cd16929 51 LLKNAMRatveshgdDSDDLPPIKVTVA-KGDEdltIKISDRGGGIPREDLARLFsymystapqpslDDFSDLISGTQPS 129
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 516459578 392 T-GGFGLGLAISRRALEAQGGTLTAQASPLGGARFRVWLP 430
Cdd:cd16929 130 PlAGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
288-372 |
7.41e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 36.63 E-value: 7.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459578 288 LDEFIDSVLGSVDDELENPEIVIDVV---LDCSVERFNLDPRLTARALQNLLRNATRYCDK-RIQVGVKVCPTGCEICVD 363
Cdd:cd16951 1 LGEYINRIASAINAIHAVGDIRINITgdtGPVSSEVATAIGLVVNELLQNALKHAFSDREGgTITIRSVVDGDYLRITVI 80
|
....*....
gi 516459578 364 DDGIGIPPD 372
Cdd:cd16951 81 DDGVGLPQD 89
|
|
| |
