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Conserved domains on  [gi|516459643|ref|WP_017848481|]
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MULTISPECIES: type II toxin-antitoxin system HigA family antitoxin [Pseudomonas]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10009358)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator; similar to Escherichia coli antitoxin HigA, which is an antitoxin component of a type II toxin-antitoxin (TA) system and functions as an mRNA interferase antitoxin

CATH:  1.10.260.40
Gene Ontology:  GO:0003677
PubMed:  10473770|2644244|15808743|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HigA COG5499
Antitoxin component HigA of the HigAB toxin-antitoxin module, contains an N-terminal HTH ...
 3-116 3.62e-53

Antitoxin component HigA of the HigAB toxin-antitoxin module, contains an N-terminal HTH domain [Defense mechanisms];


:

Pssm-ID: 444250  Cd Length: 127  Bit Score: 162.69  E-value: 3.62e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459643   3 IKPIHSQEDLTAALARVEQIWEA-PIGSPEGDELEILAVLIEKYEAEHYPMPPSDPVEAIRFRMEQLGMTARDLEAFIGT 81
Cdd:COG5499   11 LKPIRTEADYEAALALIEELLDAdELGTPEGDLLDLLATLIEAYEAKHYPIPPPDPIEALKFLMEQHGLTQKDLAPEIGS 90

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 516459643  82 SGRVSEVLNRKRKLSLSMIKRLHEGLSIPYERLLA 116
Cdd:COG5499   91 KSRVSEILNGKRSLTLEMIRKLAERFGIPAELFIQ 125
 
Name Accession Description Interval E-value
HigA COG5499
Antitoxin component HigA of the HigAB toxin-antitoxin module, contains an N-terminal HTH ...
 3-116 3.62e-53

Antitoxin component HigA of the HigAB toxin-antitoxin module, contains an N-terminal HTH domain [Defense mechanisms];


Pssm-ID: 444250  Cd Length: 127  Bit Score: 162.69  E-value: 3.62e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459643   3 IKPIHSQEDLTAALARVEQIWEA-PIGSPEGDELEILAVLIEKYEAEHYPMPPSDPVEAIRFRMEQLGMTARDLEAFIGT 81
Cdd:COG5499   11 LKPIRTEADYEAALALIEELLDAdELGTPEGDLLDLLATLIEAYEAKHYPIPPPDPIEALKFLMEQHGLTQKDLAPEIGS 90

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 516459643  82 SGRVSEVLNRKRKLSLSMIKRLHEGLSIPYERLLA 116
Cdd:COG5499   91 KSRVSEILNGKRSLTLEMIRKLAERFGIPAELFIQ 125
 
Name Accession Description Interval E-value
HigA COG5499
Antitoxin component HigA of the HigAB toxin-antitoxin module, contains an N-terminal HTH ...
 3-116 3.62e-53

Antitoxin component HigA of the HigAB toxin-antitoxin module, contains an N-terminal HTH domain [Defense mechanisms];


Pssm-ID: 444250  Cd Length: 127  Bit Score: 162.69  E-value: 3.62e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516459643   3 IKPIHSQEDLTAALARVEQIWEA-PIGSPEGDELEILAVLIEKYEAEHYPMPPSDPVEAIRFRMEQLGMTARDLEAFIGT 81
Cdd:COG5499   11 LKPIRTEADYEAALALIEELLDAdELGTPEGDLLDLLATLIEAYEAKHYPIPPPDPIEALKFLMEQHGLTQKDLAPEIGS 90

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 516459643  82 SGRVSEVLNRKRKLSLSMIKRLHEGLSIPYERLLA 116
Cdd:COG5499   91 KSRVSEILNGKRSLTLEMIRKLAERFGIPAELFIQ 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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