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Conserved domains on  [gi|516503490|ref|WP_017891928|]
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MULTISPECIES: TcdB toxin N-terminal helical domain-containing protein [Serratia]

Protein Classification

TcdB_N and Gly_transf_sug domain-containing protein( domain architecture ID 10584100)

TcdB_N and Gly_transf_sug domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TcdB_N pfam12918
TcdB toxin N-terminal helical domain; This is a short helical bundle domain found associated ...
 18-80 1.22e-14

TcdB toxin N-terminal helical domain; This is a short helical bundle domain found associated with the catalytic domain of the TcdB toxin from C. difficile. The function of this domain is unknown, but it may be involved in substrate recognition.


:

Pssm-ID: 403966 [Multi-domain]  Cd Length: 66  Bit Score: 68.93  E-value: 1.22e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516503490   18 AEYEARISELKFEFVKYQRQTSPARLESFQRGVAQLREWRAAHGHLFNADRCSSLFCVPTRPL 80
Cdd:pfam12918   1 TEYDLTIENLEEKLNKLTEEQKPKKYLLLKKLKKAIDNYNNLYKNEKNSRKGQALLVKQADLL 63
OCH1 super family cl34671
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
186-262 3.79e-08

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3774:

Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 52.58  E-value: 3.79e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516503490 186 DKRYYATLSDYFRFLILIEMGGLYMDIDTIPHRSATLFLTKPELpdYLQFlpagEVSHVSWLNlfldeTGMIISRKG 262
Cdd:COG3774   62 KLKKGAARADLFRLLLLYKYGGIYLDIDVECLKPLDPLLDGDDL--FLGY----EDPPPGIIS-----NGFIAAEPG 127
Gly_transf_sug super family cl19952
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 85-223 3.42e-05

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


The actual alignment was detected with superfamily member pfam12919:

Pssm-ID: 418730 [Multi-domain]  Cd Length: 382  Bit Score: 46.75  E-value: 3.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516503490   85 KRLHRIWLGGAIPDDAREVISQWGDaqqVVASVETNDWV--GMLWVW------------DAQQLAR-------------- 136
Cdd:pfam12919   1 KNLHFVWIGGAIPDIQEDYINVWKD---VNEGYNINLWYdsNAFLAWtlkkilvesaftAALQDLReatdfdtkkfvkkr 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516503490  137 -------------DTCFIPVPVIKGG----------YL-GEYD-----------------AGNHRLQVHSLSELAQKRVG 175
Cdd:pfam12919  78 meliydrekkivaQKAFINFYKAQGNgntndeirkeYLsNEYSldteelesylekslrkiLGNDGFDIRDIKSFKQAELV 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 516503490  176 DNlgFIHQLHDKRYYATLSDYFRFLILIEMGGLYMDIDTIPHRSATLF 223
Cdd:pfam12919 158 NN--YEQELFLRGNLAAASDIVRLLALKELGGLYTDVDMLPGISQTLF 203
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 572-653 3.91e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 42.72  E-value: 3.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516503490 572 DDYFICSLAIESQFRGQGHFNQMFALIKQRADRQQAKNIVLCVWQSSEASQ-IYLNKGFRVRGVFDQAWSlffDRLLFLE 650
Cdd:COG0456   12 DEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIaLYEKLGFEEVGERPNYYG---DDALVME 88


                 ...
gi 516503490 651 YEL 653
Cdd:COG0456   89 KEL 91
 
Name Accession Description Interval E-value
TcdB_N pfam12918
TcdB toxin N-terminal helical domain; This is a short helical bundle domain found associated ...
 18-80 1.22e-14

TcdB toxin N-terminal helical domain; This is a short helical bundle domain found associated with the catalytic domain of the TcdB toxin from C. difficile. The function of this domain is unknown, but it may be involved in substrate recognition.


Pssm-ID: 403966 [Multi-domain]  Cd Length: 66  Bit Score: 68.93  E-value: 1.22e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516503490   18 AEYEARISELKFEFVKYQRQTSPARLESFQRGVAQLREWRAAHGHLFNADRCSSLFCVPTRPL 80
Cdd:pfam12918   1 TEYDLTIENLEEKLNKLTEEQKPKKYLLLKKLKKAIDNYNNLYKNEKNSRKGQALLVKQADLL 63
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
186-262 3.79e-08

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 52.58  E-value: 3.79e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516503490 186 DKRYYATLSDYFRFLILIEMGGLYMDIDTIPHRSATLFLTKPELpdYLQFlpagEVSHVSWLNlfldeTGMIISRKG 262
Cdd:COG3774   62 KLKKGAARADLFRLLLLYKYGGIYLDIDVECLKPLDPLLDGDDL--FLGY----EDPPPGIIS-----NGFIAAEPG 127
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 180-219 2.56e-06

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 46.17  E-value: 2.56e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 516503490  180 FIHQLHDKR-YYATLSDYFRFLILIEMGGLYMDIDTIPHRS 219
Cdd:pfam04488  42 WFLEAYSLLpLFIAKSDLLRYAILYKYGGIYLDTDVIPLKS 82
TcdA_TcdB pfam12919
TcdA/TcdB catalytic glycosyltransferase domain; This domain represents the N-terminal ...
 85-223 3.42e-05

TcdA/TcdB catalytic glycosyltransferase domain; This domain represents the N-terminal glycosyltransferase from a set of toxins found in some bacteria. This domain in TcdB glycosylates the host RhoA protein.


Pssm-ID: 372382 [Multi-domain]  Cd Length: 382  Bit Score: 46.75  E-value: 3.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516503490   85 KRLHRIWLGGAIPDDAREVISQWGDaqqVVASVETNDWV--GMLWVW------------DAQQLAR-------------- 136
Cdd:pfam12919   1 KNLHFVWIGGAIPDIQEDYINVWKD---VNEGYNINLWYdsNAFLAWtlkkilvesaftAALQDLReatdfdtkkfvkkr 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516503490  137 -------------DTCFIPVPVIKGG----------YL-GEYD-----------------AGNHRLQVHSLSELAQKRVG 175
Cdd:pfam12919  78 meliydrekkivaQKAFINFYKAQGNgntndeirkeYLsNEYSldteelesylekslrkiLGNDGFDIRDIKSFKQAELV 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 516503490  176 DNlgFIHQLHDKRYYATLSDYFRFLILIEMGGLYMDIDTIPHRSATLF 223
Cdd:pfam12919 158 NN--YEQELFLRGNLAAASDIVRLLALKELGGLYTDVDMLPGISQTLF 203
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 572-653 3.91e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 42.72  E-value: 3.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516503490 572 DDYFICSLAIESQFRGQGHFNQMFALIKQRADRQQAKNIVLCVWQSSEASQ-IYLNKGFRVRGVFDQAWSlffDRLLFLE 650
Cdd:COG0456   12 DEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIaLYEKLGFEEVGERPNYYG---DDALVME 88


                 ...
gi 516503490 651 YEL 653
Cdd:COG0456   89 KEL 91
 
Name Accession Description Interval E-value
TcdB_N pfam12918
TcdB toxin N-terminal helical domain; This is a short helical bundle domain found associated ...
 18-80 1.22e-14

TcdB toxin N-terminal helical domain; This is a short helical bundle domain found associated with the catalytic domain of the TcdB toxin from C. difficile. The function of this domain is unknown, but it may be involved in substrate recognition.


Pssm-ID: 403966 [Multi-domain]  Cd Length: 66  Bit Score: 68.93  E-value: 1.22e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516503490   18 AEYEARISELKFEFVKYQRQTSPARLESFQRGVAQLREWRAAHGHLFNADRCSSLFCVPTRPL 80
Cdd:pfam12918   1 TEYDLTIENLEEKLNKLTEEQKPKKYLLLKKLKKAIDNYNNLYKNEKNSRKGQALLVKQADLL 63
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
186-262 3.79e-08

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 52.58  E-value: 3.79e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516503490 186 DKRYYATLSDYFRFLILIEMGGLYMDIDTIPHRSATLFLTKPELpdYLQFlpagEVSHVSWLNlfldeTGMIISRKG 262
Cdd:COG3774   62 KLKKGAARADLFRLLLLYKYGGIYLDIDVECLKPLDPLLDGDDL--FLGY----EDPPPGIIS-----NGFIAAEPG 127
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 180-219 2.56e-06

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 46.17  E-value: 2.56e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 516503490  180 FIHQLHDKR-YYATLSDYFRFLILIEMGGLYMDIDTIPHRS 219
Cdd:pfam04488  42 WFLEAYSLLpLFIAKSDLLRYAILYKYGGIYLDTDVIPLKS 82
TcdA_TcdB pfam12919
TcdA/TcdB catalytic glycosyltransferase domain; This domain represents the N-terminal ...
 85-223 3.42e-05

TcdA/TcdB catalytic glycosyltransferase domain; This domain represents the N-terminal glycosyltransferase from a set of toxins found in some bacteria. This domain in TcdB glycosylates the host RhoA protein.


Pssm-ID: 372382 [Multi-domain]  Cd Length: 382  Bit Score: 46.75  E-value: 3.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516503490   85 KRLHRIWLGGAIPDDAREVISQWGDaqqVVASVETNDWV--GMLWVW------------DAQQLAR-------------- 136
Cdd:pfam12919   1 KNLHFVWIGGAIPDIQEDYINVWKD---VNEGYNINLWYdsNAFLAWtlkkilvesaftAALQDLReatdfdtkkfvkkr 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516503490  137 -------------DTCFIPVPVIKGG----------YL-GEYD-----------------AGNHRLQVHSLSELAQKRVG 175
Cdd:pfam12919  78 meliydrekkivaQKAFINFYKAQGNgntndeirkeYLsNEYSldteelesylekslrkiLGNDGFDIRDIKSFKQAELV 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 516503490  176 DNlgFIHQLHDKRYYATLSDYFRFLILIEMGGLYMDIDTIPHRSATLF 223
Cdd:pfam12919 158 NN--YEQELFLRGNLAAASDIVRLLALKELGGLYTDVDMLPGISQTLF 203
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 572-653 3.91e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 42.72  E-value: 3.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516503490 572 DDYFICSLAIESQFRGQGHFNQMFALIKQRADRQQAKNIVLCVWQSSEASQ-IYLNKGFRVRGVFDQAWSlffDRLLFLE 650
Cdd:COG0456   12 DEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIaLYEKLGFEEVGERPNYYG---DDALVME 88


                 ...
gi 516503490 651 YEL 653
Cdd:COG0456   89 KEL 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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