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Conserved domains on  [gi|516619090|ref|WP_017993877|]
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DUF192 domain-containing protein [Rhizobium leguminosarum]

Protein Classification

DUF192 domain-containing protein( domain architecture ID 10003666)

DUF192 domain-containing protein similar to Methanocaldococcus jannaschii UPF0127 protein MJ1496

CATH:  2.60.120.1140
SCOP:  4007008

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG1430 COG1430
Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];
13-153 1.09e-46

Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];


:

Pssm-ID: 441039  Cd Length: 138  Bit Score: 148.51  E-value: 1.09e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516619090  13 ALLALFFMVALPALADEEMRFDKeplliqtaagKVLHFTVEIASTPDQRAHGLMFRKVMADDAGMIFDFDEPRRVTMWME 92
Cdd:COG1430    2 LLALLLLALAAAALPTGELTINT----------AGLAIDVEVADTFEERARGLMFRKSLPEDEGMLFVFDEPRCRSFWMK 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516619090  93 NTILPLDMLFADDTGTIRHIKEKAVPYSRDIIDSMVAVKYVVELNAGIVAKLGIKPGDRIV 153
Cdd:COG1430   72 NTRFPLDIIFLDADGRIVSIAENLPPCSWTSYPSGGPARYVLELPAGWAARLGIKVGDRLE 132
 
Name Accession Description Interval E-value
COG1430 COG1430
Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];
13-153 1.09e-46

Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];


Pssm-ID: 441039  Cd Length: 138  Bit Score: 148.51  E-value: 1.09e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516619090  13 ALLALFFMVALPALADEEMRFDKeplliqtaagKVLHFTVEIASTPDQRAHGLMFRKVMADDAGMIFDFDEPRRVTMWME 92
Cdd:COG1430    2 LLALLLLALAAAALPTGELTINT----------AGLAIDVEVADTFEERARGLMFRKSLPEDEGMLFVFDEPRCRSFWMK 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516619090  93 NTILPLDMLFADDTGTIRHIKEKAVPYSRDIIDSMVAVKYVVELNAGIVAKLGIKPGDRIV 153
Cdd:COG1430   72 NTRFPLDIIFLDADGRIVSIAENLPPCSWTSYPSGGPARYVLELPAGWAARLGIKVGDRLE 132
DUF192 pfam02643
Uncharacterized ACR, COG1430; Two structures have been solved for members of this large (>500 ...
 51-153 1.24e-46

Uncharacterized ACR, COG1430; Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologs are also present in several Plasmodium species). TOPSAN analysis for pdb:3pjy shows that there is much similarity with the other solved structure, pdb:3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homolog of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homolog in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. PDB:3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).


Pssm-ID: 460636  Cd Length: 104  Bit Score: 147.26  E-value: 1.24e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516619090   51 TVEIASTPDQRAHGLMFRKVMADDAGMIFDFDEPRRVTMWMENTILPLDMLFADDTGTIRHIKEKAVPYSRDIIDSMVAV 130
Cdd:pfam02643   1 DVEVADTPEERARGLMFRTSLPEDEGMLFVFDRPQPHSFWMKNTLFPLDIIFIDADGRIVAIEENVPPCSEEPCPSPGPV 80

                          90       100
                  ....*....|....*....|...
gi 516619090  131 KYVVELNAGIVAKLGIKPGDRIV 153
Cdd:pfam02643  81 RYVLELPAGWAAKLGIKVGDRVE 103
PRK03760 PRK03760
hypothetical protein; Provisional
 39-152 1.82e-04

hypothetical protein; Provisional


Pssm-ID: 235157  Cd Length: 117  Bit Score: 38.91  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516619090  39 LIQTAAGKVLHFTVEIASTPDQRAHGLMFRKVMadDAGMIFDFDEPRRV--TMWMENTILPLDMLFADDTGTIRHIKeKA 116
Cdd:PRK03760   2 IINKTKGKSWHGAVRFADTFIKRFRGLMLVRNV--NYALVFILPAETRFnaSIHMFFMLSSIDVIFLDSNRRVVDFK-TL 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 516619090 117 VPYSrdIIDSMVAVKYVVELNAGIVAKLGIKPGDRI 152
Cdd:PRK03760  79 KPWR--IYVPKKPARYIIEGPVGKIRVLKVEVGDEI 112
 
Name Accession Description Interval E-value
COG1430 COG1430
Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];
13-153 1.09e-46

Uncharacterized conserved membrane protein, UPF0127 family [Function unknown];


Pssm-ID: 441039  Cd Length: 138  Bit Score: 148.51  E-value: 1.09e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516619090  13 ALLALFFMVALPALADEEMRFDKeplliqtaagKVLHFTVEIASTPDQRAHGLMFRKVMADDAGMIFDFDEPRRVTMWME 92
Cdd:COG1430    2 LLALLLLALAAAALPTGELTINT----------AGLAIDVEVADTFEERARGLMFRKSLPEDEGMLFVFDEPRCRSFWMK 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516619090  93 NTILPLDMLFADDTGTIRHIKEKAVPYSRDIIDSMVAVKYVVELNAGIVAKLGIKPGDRIV 153
Cdd:COG1430   72 NTRFPLDIIFLDADGRIVSIAENLPPCSWTSYPSGGPARYVLELPAGWAARLGIKVGDRLE 132
DUF192 pfam02643
Uncharacterized ACR, COG1430; Two structures have been solved for members of this large (>500 ...
 51-153 1.24e-46

Uncharacterized ACR, COG1430; Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologs are also present in several Plasmodium species). TOPSAN analysis for pdb:3pjy shows that there is much similarity with the other solved structure, pdb:3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homolog of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homolog in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. PDB:3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).


Pssm-ID: 460636  Cd Length: 104  Bit Score: 147.26  E-value: 1.24e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516619090   51 TVEIASTPDQRAHGLMFRKVMADDAGMIFDFDEPRRVTMWMENTILPLDMLFADDTGTIRHIKEKAVPYSRDIIDSMVAV 130
Cdd:pfam02643   1 DVEVADTPEERARGLMFRTSLPEDEGMLFVFDRPQPHSFWMKNTLFPLDIIFIDADGRIVAIEENVPPCSEEPCPSPGPV 80

                          90       100
                  ....*....|....*....|...
gi 516619090  131 KYVVELNAGIVAKLGIKPGDRIV 153
Cdd:pfam02643  81 RYVLELPAGWAAKLGIKVGDRVE 103
PRK03760 PRK03760
hypothetical protein; Provisional
 39-152 1.82e-04

hypothetical protein; Provisional


Pssm-ID: 235157  Cd Length: 117  Bit Score: 38.91  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516619090  39 LIQTAAGKVLHFTVEIASTPDQRAHGLMFRKVMadDAGMIFDFDEPRRV--TMWMENTILPLDMLFADDTGTIRHIKeKA 116
Cdd:PRK03760   2 IINKTKGKSWHGAVRFADTFIKRFRGLMLVRNV--NYALVFILPAETRFnaSIHMFFMLSSIDVIFLDSNRRVVDFK-TL 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 516619090 117 VPYSrdIIDSMVAVKYVVELNAGIVAKLGIKPGDRI 152
Cdd:PRK03760  79 KPWR--IYVPKKPARYIIEGPVGKIRVLKVEVGDEI 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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