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Conserved domains on  [gi|516659797|ref|WP_018027279|]
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sugar transporter [Oligella urethralis]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 7-384 5.75e-131

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member PRK03545:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 390  Bit Score: 381.16  E-value: 5.75e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   7 QATPKGSWFAVITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILL 86
Cdd:PRK03545   1 TVSRKVAWLRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  87 FVLFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHL 166
Cdd:PRK03545  81 FVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 167 GWRVTFGLIGVMAAIILALLWRTLPKLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSN 246
Cdd:PRK03545 161 GWRTTFLAIGGGALITLLLLIKLLPLLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 247 HMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQSKVL 326
Cdd:PRK03545 241 NFATLLLLLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVL 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516659797 327 ENAADAPDIGVAIFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVITLIAFWW 384
Cdd:PRK03545 321 KLAPDATDVAMALFSGIFNIGIGAGALLGNQVSLHLGLSSIGYVGAALALAALVWSIL 378
 
Name Accession Description Interval E-value
PRK03545 PRK03545
putative arabinose transporter; Provisional
 7-384 5.75e-131

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 381.16  E-value: 5.75e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   7 QATPKGSWFAVITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILL 86
Cdd:PRK03545   1 TVSRKVAWLRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  87 FVLFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHL 166
Cdd:PRK03545  81 FVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 167 GWRVTFGLIGVMAAIILALLWRTLPKLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSN 246
Cdd:PRK03545 161 GWRTTFLAIGGGALITLLLLIKLLPLLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 247 HMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQSKVL 326
Cdd:PRK03545 241 NFATLLLLLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVL 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516659797 327 ENAADAPDIGVAIFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVITLIAFWW 384
Cdd:PRK03545 321 KLAPDATDVAMALFSGIFNIGIGAGALLGNQVSLHLGLSSIGYVGAALALAALVWSIL 378
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 17-383 1.35e-65

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 212.79  E-value: 1.35e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  17 VITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHAL 96
Cdd:cd17324    1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  97 AAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIG 176
Cdd:cd17324   81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 177 VMAAIILALLWRTLPKL---SSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMML 253
Cdd:cd17324  161 VLALLAALLLWRLLPSLppkKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 254 FVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQSKVLENAADAP 333
Cdd:cd17324  241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 516659797 334 DIGVAIFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVITLIAFW 383
Cdd:cd17324  321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
7-332 8.55e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 120.46  E-value: 8.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   7 QATPKGSWFAVITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILL 86
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  87 FVLFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHL 166
Cdd:COG2814   82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 167 GWRVTFGLIGVMAAIILALLWRTLPKLSSQSSG-SLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMS 245
Cdd:COG2814  162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARArLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 246 NHMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQSKV 325
Cdd:COG2814  242 ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALV 321


                 ....*..
gi 516659797 326 LENAADA 332
Cdd:COG2814  322 AELAPPE 328
2_A_01_02 TIGR00880
Multidrug resistance protein;
53-191 1.08e-15

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 73.45  E-value: 1.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   53 GLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLA 132
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 516659797  133 PKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIGVMAAIILALLWRTLP 191
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
MFS_1 pfam07690
Major Facilitator Superfamily;
19-309 1.41e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 65.13  E-value: 1.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   19 TLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAA 98
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   99 VAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIGVM 178
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  179 AAIILALLWRTLPKLSSQSSGSLSVVPA-------LLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVG---GMSNHM 248
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLslivawkALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGlsaLLAGLL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516659797  249 VVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIV 309
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
 
Name Accession Description Interval E-value
PRK03545 PRK03545
putative arabinose transporter; Provisional
 7-384 5.75e-131

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 381.16  E-value: 5.75e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   7 QATPKGSWFAVITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILL 86
Cdd:PRK03545   1 TVSRKVAWLRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  87 FVLFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHL 166
Cdd:PRK03545  81 FVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 167 GWRVTFGLIGVMAAIILALLWRTLPKLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSN 246
Cdd:PRK03545 161 GWRTTFLAIGGGALITLLLLIKLLPLLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 247 HMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQSKVL 326
Cdd:PRK03545 241 NFATLLLLLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVL 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516659797 327 ENAADAPDIGVAIFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVITLIAFWW 384
Cdd:PRK03545 321 KLAPDATDVAMALFSGIFNIGIGAGALLGNQVSLHLGLSSIGYVGAALALAALVWSIL 378
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 17-383 1.35e-65

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 212.79  E-value: 1.35e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  17 VITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHAL 96
Cdd:cd17324    1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  97 AAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIG 176
Cdd:cd17324   81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 177 VMAAIILALLWRTLPKL---SSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMML 253
Cdd:cd17324  161 VLALLAALLLWRLLPSLppkKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 254 FVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQSKVLENAADAP 333
Cdd:cd17324  241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 516659797 334 DIGVAIFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVITLIAFW 383
Cdd:cd17324  321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
7-332 8.55e-31

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 120.46  E-value: 8.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   7 QATPKGSWFAVITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILL 86
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  87 FVLFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHL 166
Cdd:COG2814   82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 167 GWRVTFGLIGVMAAIILALLWRTLPKLSSQSSG-SLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMS 245
Cdd:COG2814  162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARArLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 246 NHMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQSKV 325
Cdd:COG2814  242 ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALV 321


                 ....*..
gi 516659797 326 LENAADA 332
Cdd:COG2814  322 AELAPPE 328
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 17-345 4.46e-26

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 107.87  E-value: 4.46e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  17 VITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHAL 96
Cdd:PRK10091   5 ILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAM 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  97 AAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIG 176
Cdd:PRK10091  85 FTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 177 VMAAIILALLWRTLPKLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMMLFVI 256
Cdd:PRK10091 165 VFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLV 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 257 GLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSL-WVLMPLAIVWGTVITLLSMVLQSKVLENAADAPDI 335
Cdd:PRK10091 245 GLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLMLFFFGGMkTASLIFAFICCAGLFALSAPLQILLLQNAKGGELL 324

                        330
                 ....*....|
gi 516659797 336 GVAIFSGVFN 345
Cdd:PRK10091 325 GAAGGQIAFN 334
nepI PRK10213
purine ribonucleoside efflux pump NepI;
3-378 8.17e-23

purine ribonucleoside efflux pump NepI;


Pssm-ID: 182309 [Multi-domain]  Cd Length: 394  Bit Score: 98.84  E-value: 8.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   3 EPVKQATPKGSWFAVITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRL 82
Cdd:PRK10213   8 NRGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  83 LILLFVLFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVI 162
Cdd:PRK10213  88 VILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 163 GHHLGWRVTFGLIGVMAAIILALLWRTLPKLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVG 242
Cdd:PRK10213 168 GELIGWRNVFNAAAVMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLA 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 243 GMSNHMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQ 322
Cdd:PRK10213 248 GFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWGLTFALVPVGWS 327

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 516659797 323 SKVLENAADAPDIGVAIFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVIT 378
Cdd:PRK10213 328 TWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLT 383
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 20-384 7.86e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 78.00  E-value: 7.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  20 LAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAAV 99
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 100 AWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIGVMA 179
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 180 AIILALLWRTLP-------KLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMM 252
Cdd:cd17325  161 LLALVLALLLLPeprpppnKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 253 LFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQSKVLENAADA 332
Cdd:cd17325  241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 516659797 333 PD-IGVAIFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVITLIAFWW 384
Cdd:cd17325  321 GRgTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
2_A_01_02 TIGR00880
Multidrug resistance protein;
53-191 1.08e-15

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 73.45  E-value: 1.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   53 GLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLA 132
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 516659797  133 PKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIGVMAAIILALLWRTLP 191
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
6-387 2.60e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 76.45  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   6 KQATPKGSWFAVITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLIL 85
Cdd:COG2271    1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  86 LFVLFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHH 165
Cdd:COG2271   81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 166 LGWRVTFGLIGVMAAIILALlwrtlpklssqssgslsvvpallkrpALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMS 245
Cdd:COG2271  161 FGWRAAFLILGLPGLLLALL--------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLS 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 246 NHMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSL--LLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQS 323
Cdd:COG2271  215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAlaLLLLALLPSPALAIALLFLAGFGLGGAFGLLWA 294

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516659797 324 KVLENA-ADAPDIGVAIFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVITLIAFWWKGR 387
Cdd:COG2271  295 LAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
11-311 3.71e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 73.38  E-value: 3.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  11 KGSWFAVITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLF 90
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  91 IASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRV 170
Cdd:COG2223   81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 171 TFGLIGVMAAIILALLWRTL----PKLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSN 246
Cdd:COG2223  161 AFLILGILLLVVAVLAWLFLrdppAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516659797 247 HMVVMMLFVIGLAGILGGIIFSRYAGRY-ALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWG 311
Cdd:COG2223  241 ATAGLLAALFALLGALGRPLGGWLSDRIgGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLG 306
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 14-274 3.70e-13

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 69.91  E-value: 3.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  14 WFAVITLAVAAFIFNTTEFVPVGL-LPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIA 92
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVaAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  93 SHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTF 172
Cdd:cd17319   81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 173 GLIGVMAAIILALLWRTLPKLSSqssgslsvvpallkrpalqyIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMM 252
Cdd:cd17319  161 IIEGLLGLLLAVLWWFYLRQVWG--------------------LALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLL 220

                        250       260
                 ....*....|....*....|..
gi 516659797 253 LFVIGLAGILGGIIFSRYAGRY 274
Cdd:cd17319  221 AAIPFLAGAIGMILGGRLSDRL 242
MFS_1 pfam07690
Major Facilitator Superfamily;
19-309 1.41e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 65.13  E-value: 1.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   19 TLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAA 98
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   99 VAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIGVM 178
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  179 AAIILALLWRTLPKLSSQSSGSLSVVPA-------LLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVG---GMSNHM 248
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLslivawkALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGlsaLLAGLL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516659797  249 VVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIV 309
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
4-311 1.74e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 59.12  E-value: 1.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   4 PVKQATPKGSWFAVITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLL 83
Cdd:COG2807    7 SARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  84 ILLFVLFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKgKTSKALSFIVTGSSLATVLGVPLGTVIG 163
Cdd:COG2807   87 LLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 164 HHLGWRVTFGLIGVMAAIILALLWRTLP--KLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTV 241
Cdd:COG2807  166 AALGWRGALAVWALLALLALLLWLPLLRrrPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 242 gGMSNHMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWG 311
Cdd:COG2807  246 -GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLG 314
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 17-345 2.12e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 58.74  E-value: 2.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  17 VITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHAL 96
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  97 AAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHlGWRVTFGLIG 176
Cdd:cd17474   81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 177 VMAAIILALLWRTLP----KLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMM 252
Cdd:cd17474  160 ALIPVAFLAILFLLPepkeKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 253 LFVIGLAGILGGIIFSRY-AGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQSKVLENaad 331
Cdd:cd17474  240 FAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTEL--- 316

                        330
                 ....*....|....
gi 516659797 332 APDIGVAIFSGVFN 345
Cdd:cd17474  317 APEEERGTASSLYN 330
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 16-311 8.54e-09

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 56.86  E-value: 8.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  16 AVITLAVAAFIFNTtefVPVgLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHA 95
Cdd:cd17475    1 ATLAQAAASLVAQG---IPA-LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAAL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  96 LAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTF--- 172
Cdd:cd17475   77 LMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFvva 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 173 GLIGVMAAIILALLWRTLPKLSSQSSGSLSV---VPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMV 249
Cdd:cd17475  157 GLVSILAAVLFWLFYREPPAASAATESASTLlrsLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAA 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516659797 250 VMMLFVIGLAGILGGIIFSR-----YAGRYALSLLLISLLGISVSLLLLKIAVHS-LWVLMPLAIVWG 311
Cdd:cd17475  237 GALLAVAQLGGALGRIGLGRvsdrvFGGRRRPVLVITAAIAAAALLVLSLLSPGTpLWLLVLLLILLG 304
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 20-383 4.52e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 54.35  E-value: 4.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  20 LAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAAV 99
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 100 AWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHL--GWRVTFGLIGV 177
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 178 MAAIILALLWRTLP---------KLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHM 248
Cdd:cd06174  161 LALLAAILLLLVVPdppesarakNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 249 VVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQSKVLen 328
Cdd:cd06174  241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI-- 318

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 516659797 329 AADAPDIGVAIFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVITLIAFW 383
Cdd:cd06174  319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLA 373
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 38-304 7.79e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 53.72  E-value: 7.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  38 LPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAAVAWNFSSLLVARIGVAMAH 117
Cdd:cd17321   19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 118 AVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIGVMAAIILALLwrtlpklssqs 197
Cdd:cd17321   99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA----------- 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 198 sgslsvvpallkrPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMMLFVIGLAGILGGIIFSRYAGRY-AL 276
Cdd:cd17321  168 -------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFgPR 234

                        250       260
                 ....*....|....*....|....*...
gi 516659797 277 SLLLISLLGISVSLLLLKIAVHSLWVLM 304
Cdd:cd17321  235 LVLVAGLLLTAVGLLLLALLGADSSVWL 262
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 38-311 1.42e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 52.96  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  38 LPDIAAGFRMDIAHT-GLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAAVAWNFSSLLVARIGVAMA 116
Cdd:cd17473   22 LPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 117 HAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHhLGWRVTFgLIGVMAAIILALLWRTLPKLSSQ 196
Cdd:cd17473  102 VAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPF-LVYLLALPVLILVLLFLPEPARK 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 197 SSGSLSVVPALLKR---PALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMMLFVIGLAGILGGIIFSRYAGR 273
Cdd:cd17473  180 SKSAASPGAATAAAlpwKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRR 259

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 516659797 274 YALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWG 311
Cdd:cd17473  260 LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAG 297
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
9-391 1.43e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 52.93  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   9 TPKGSWFAVITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFV 88
Cdd:COG0738    2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  89 LFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKaLSFIVTGSSLATVLGVPLGTVI---GHH 165
Cdd:COG0738   82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLillGLS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 166 LGWRVTFGLIGVMAAIILALLWRT----LPKLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTV 241
Cdd:COG0738  161 LSWHLPYLILAVLLLLLALLFLRSklpeIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 242 GGMSNHMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVL 321
Cdd:COG0738  241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 322 QSKVLENAADAPDIGVAIFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVITLIAFWWKGRLLTS 391
Cdd:COG0738  321 FSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 38-319 2.54e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 52.19  E-value: 2.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  38 LPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAAVAWNFSSLLVARIGVAMAH 117
Cdd:cd17320   22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 118 AVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIGVMAAIILALLWRTLP------ 191
Cdd:cd17320  102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPetlpee 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 192 KLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMMLFVIGLAGILGGIIFSRYA 271
Cdd:cd17320  182 KRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLV 261

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 516659797 272 GRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSM 319
Cdd:cd17320  262 RRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGF 309
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 102-386 3.86e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.44  E-value: 3.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 102 NFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIGVMAAI 181
Cdd:cd17489   83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 182 ILALLW--RTLPKLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTvGGMSNHMVVMMLFviGLA 259
Cdd:cd17489  163 ALLLVFlvKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAE-RGISNAGLFFTVY--AIA 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 260 GILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQSKVLENA-ADAPDIGVA 338
Cdd:cd17489  240 LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVpPHRRGAANG 319

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 516659797 339 IFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVITLIAFWWKG 386
Cdd:cd17489  320 TFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 31-191 3.93e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 48.39  E-value: 3.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  31 EFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAAVAWNFSSLLVAR 110
Cdd:cd17328   15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 111 IGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHH-LGWRVTFGLIGVMAAIILALLWRT 189
Cdd:cd17328   95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLF 174


                 ..
gi 516659797 190 LP 191
Cdd:cd17328  175 VR 176
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 8-293 1.51e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 46.34  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   8 ATPKGSWFAVITLAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLF 87
Cdd:COG0477    7 APTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  88 VLFIASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLG 167
Cdd:COG0477   87 LLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 168 WRVTFgLIGVMAAIILALLWRTLPKLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNH 247
Cdd:COG0477  167 WRWIF-LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 516659797 248 MVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLL 293
Cdd:COG0477  246 LLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 20-321 2.56e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 46.03  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  20 LAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAAV 99
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 100 AWNFSSLLVARI--GVAMAhavfwaiTIPLAVRLA----PKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFG 173
Cdd:cd17504   81 APNLPVLIAGRAlqGIGGA-------VFPLAFALVreefPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFW 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 174 LIGVMAAIILALLwrtlpklssqssgsLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMML 253
Cdd:cd17504  154 TAAPVAVLLAALV--------------PLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEA 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516659797 254 FVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVL 321
Cdd:cd17504  220 GLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGL 287
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 95-385 5.92e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.91  E-value: 5.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  95 ALAAVAWNFSSLLVARIGVAMAHAVFWAITIP----LAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRV 170
Cdd:cd06173   80 VLALLALLGSLSLWLLLVLAFLLGIASAFFGParqaLLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 171 TFGLIGVMAAIILALLWRTLPKLSSQSSGSLSVVPA--------LLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVG 242
Cdd:cd06173  160 AFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRdlreglryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 243 GMSNHMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQ 322
Cdd:cd06173  240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516659797 323 SKVLENAADAPDIGV-AIFSGVFNIGIGGGALLGGQMINHVGLANIPYVGAILAVITLIAFWWK 385
Cdd:cd06173  320 TLLQLRVPDELRGRVfSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 20-273 7.10e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 44.49  E-value: 7.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  20 LAVAAFIFNTTEFVPVGLLPDIAAGFRMDIAHTGLLMTLYAWAVTIFsLPLTMVTAG-VERRRLLILLFVLFIASHALAA 98
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIM-IPLSGWLADrFGTRRLFLTALALFTLGSLLCG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  99 VAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFgLIGVM 178
Cdd:cd17503   80 LAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF-YINLP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 179 AAIILALLwrtlpklssqssgSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMMLFVIGL 258
Cdd:cd17503  159 IGILALLL-------------APLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGL 225

                        250
                 ....*....|....*....
gi 516659797 259 AGI----LGGIIFSRYAGR 273
Cdd:cd17503  226 ASAilspLVGRLLDKFGPR 244
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 102-328 8.83e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 44.13  E-value: 8.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 102 NFSSLLVARI--GVAmahAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTF--GLIGV 177
Cdd:cd17490   84 SPWGLLIARFlsGIA---AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFllAALAG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 178 MAAIILALLWRTLPKLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMMLFVIG 257
Cdd:cd17490  161 VLGFILSLFIKEERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYL 240

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516659797 258 LAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHS-LWVLMPLAIVWGTVITLLSMVLQSKVLEN 328
Cdd:cd17490  241 LPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPnLTLLYLLQALNGFGTGILFPLLMSLSIEG 312
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 133-318 2.19e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.92  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 133 PKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIGVMAAIILALLWRTLP--KLSSQSSGSLSVVPALLKR 210
Cdd:cd17471  119 SGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPsvKPPAQKATPASSLVKAPVN 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 211 PALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSL 290
Cdd:cd17471  199 RRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLF 278

                        170       180
                 ....*....|....*....|....*...
gi 516659797 291 LLLKIAVHSLWVLMPLAIVWGTVITLLS 318
Cdd:cd17471  279 YLGLALATSLWQLIALQLLNAIFIGITA 306
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 95-311 3.39e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 42.34  E-value: 3.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797   95 ALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGL 174
Cdd:TIGR00895  97 LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  175 IGVMAAIILALLWRTLP--------KLSSQSSGSLSVVPALLKRPAL-----------------------QYIYLSLALI 223
Cdd:TIGR00895 177 GGIAPLLLLLLLMRFLPesidflvsKRPETVRRIVNAIAPQMQAEAQsalpeqkstqgtkrsvfkalfqgKTARITVLLW 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  224 MTAHFTVSTYI-----SPYLQTVGGMSNHMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVH 298
Cdd:TIGR00895 257 LLYFMLLVGVYfltnwLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLF 336

                         250
                  ....*....|...
gi 516659797  299 SLWVLMPLAIVWG 311
Cdd:TIGR00895 337 SPTLLLLLGAIAG 349
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 14-267 4.37e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 41.90  E-value: 4.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  14 WFAVITLAVAAFIFNTTEFVpvglLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIAS 93
Cdd:cd17371    2 WAAFLGWALDGFDLLLLGLV----LPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  94 HALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSS----LATVLGVPLGTVIGHHLGWR 169
Cdd:cd17371   78 TLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvgwlLATLLAALLFPLLPPEIAWR 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 170 VTFgLIGVMAAIILALLWRTLP-------KLSSQSSGSLSVVPALLKRPALQYIYLSLALIMT----AHFTVSTYISPYL 238
Cdd:cd17371  158 VLF-LLGALPALLVLFIRRFVKeppqwqaARAARRHFADRPSLRELFSPPLLRTTLLASLLATgalgGYYGITTWLPSYL 236

                        250       260
                 ....*....|....*....|....*....
gi 516659797 239 QTVGGMSNHMVVMMLFVIGLAGILGGIIF 267
Cdd:cd17371  237 TGERGLSFEGSAGYLVVTILGGFLGYLAG 265
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
143-323 7.79e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 7.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 143 FIVTGSSLATVLGVPLGTVIG--HHLGWRVTF---GLIGVMAAIILALLWRTLPKLSSQSSGSLSVVPALLKRPALQYIY 217
Cdd:COG2211  155 FAGLGGLLASVLPPPLVAAFGgdAALGYRLTAlifAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLL 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 218 LSLALIMTAHFTVSTYISPYLQTVGGMSNHMVVMMLFVIGLAGILGGIIFSRYAGRY--ALSLLLISLLGISVSLLLLKI 295
Cdd:COG2211  235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgkKKAFIIGLLLAALGLLLLFFL 314

                        170       180
                 ....*....|....*....|....*...
gi 516659797 296 AVHSLWVLMPLAIVWGTVITLLSMVLQS 323
Cdd:COG2211  315 GPGNLWLLLVLAALAGIGLGAILVLPWA 342
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 138-323 9.11e-04

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 41.05  E-value: 9.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 138 SKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIGVMAAIILALLWRTLP---KLSSQSSGSLSVVPALLKRPALQ 214
Cdd:cd17472  118 TKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPdppKIVQISEKEKKKLKKLLKNKRLL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 215 YIYLS---LALIMTAHFTVstyISPYLQTVGGMSNHMVVMMLFVIGLAGILgGIIFSRYA--GRYALSLLLISLLGISVS 289
Cdd:cd17472  198 RLDFSifiLHFVLMAFFYI---LPLLLTQLGGGKGQLWKVYLPAILIGFIL-MVPFVIYAekKGKMKQVFVSSILLIAVG 273

                        170       180       190
                 ....*....|....*....|....*....|....
gi 516659797 290 LLLLKIAVHSLWVLMPLAIVWGTVITLLSMVLQS 323
Cdd:cd17472  274 FLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPS 307
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 96-191 1.36e-03

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 40.84  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  96 LAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFgLI 175
Cdd:PRK03893 101 ACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALF-FI 179

                         90
                 ....*....|....*.
gi 516659797 176 GVMAAIILALLWRTLP 191
Cdd:PRK03893 180 GILPIIFALWLRKNLP 195
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 37-314 4.35e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.69  E-value: 4.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  37 LLPDIAAGFRMDIAHTGLLMTLYAWAVTIFSLPLTMVTAGVERRRLLILLFVLFIASHALAAVAWNFSSLLVARIGVAMA 116
Cdd:cd17478   18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 117 HAVFWAITIPLAvRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHLGWRVTFGLIGVMAAIILALLWRTLPKLSSQ 196
Cdd:cd17478   98 SAAFHPEGARLA-SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 197 SSGSLSVVPALLKRPALQYIYLSLALIMT----AHFTVSTYISPYLQTVGGmSNHMVVMMLFVIGLAGILGGIIFSRYAG 272
Cdd:cd17478  177 AKKAAAKSSARSTLKGVWRALLLLLIIVFlrswVLSSLTTFLPFYLVQRGY-SLVFAGLLLSLFLFAGAIGTLIGGPLSD 255

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 516659797 273 RYALSLLLISLLGISVSLLLLkIAVHSLWVLMPLAIVWGTVI 314
Cdd:cd17478  256 RFGRRRVIIASLLLAAPFLLL-FLLTPGIWSYILLVLAGFLL 296
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 95-267 5.34e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 38.74  E-value: 5.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  95 ALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHHL----GWRV 170
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 171 TFGLIGVMAAIILALLWRTLpklssqssgslsvvpallkrpalqYIYLSLALIMTAHFTVSTYISPYLQTVGGMSNHMVV 250
Cdd:cd17316  161 LFLIGALPALLALLLRRRTL------------------------LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSS 216

                        170
                 ....*....|....*..
gi 516659797 251 MMLFVIGLAGILGGIIF 267
Cdd:cd17316  217 LYLLLISLGALVGALIA 233
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 92-310 8.23e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 37.98  E-value: 8.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797  92 ASHALAAVAWNFSSLLVARIGVAMAHAVFWAITIPLAVRLAPKGKTSKALSFIVTGSSLATVLGVPLGTVIGHhLGWRVT 171
Cdd:cd17329   77 LGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516659797 172 FGLIGVMAAIILALLWRTLP-----KLSSQSSGSLSVVPALLKRPALQYIYLSLALIMTAHFTVSTYISPYLQTVGGMSN 246
Cdd:cd17329  156 FLAAAVLFLLAALVLLFLLPetrpkRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGE 235

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516659797 247 HMVVMMLFVIGLAGILGGIIFSRYAGRYALSLLLISLLGISVSLLLLKIAVHSLWVLMPLAIVW 310
Cdd:cd17329  236 SLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVL 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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