NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|516730510|ref|WP_018070867|]
View 

TetR family transcriptional regulator [Rhizobium ruizarguesonis]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TetR_C_24 super family cl38973
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 87-177 5.00e-11

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


The actual alignment was detected with superfamily member pfam17935:

Pssm-ID: 476837  Cd Length: 106  Bit Score: 57.56  E-value: 5.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516730510   87 AASRLKETALGQHRLMLRARHGDSQMFDLIVLAAEGNWPSFRDHLKRLQAYVGELVATGIATEEFAPRNVDTAAACFCAS 166
Cdd:pfam17935   1 APERLREWLLRLFRAKRRKALDDPELFATYVVLIEEALEVVAAHIDLLDGQLAEIIREGVADGEFTAADPAAAARAVFDA 80

                          90
                  ....*....|.
gi 516730510  167 IISLWDPRIIG 177
Cdd:pfam17935  81 TARFHHPAHAA 91
TetR_N super family cl37988
Bacterial regulatory proteins, tetR family;
19-65 8.86e-03

Bacterial regulatory proteins, tetR family;


The actual alignment was detected with superfamily member pfam00440:

Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 33.15  E-value: 8.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 516730510   19 IIEAGTAACRLYGLSKTNVVDIARLLGKSPASVYKIFPSKAAIWDAI 65
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
TetR_C_27 pfam17935
Tetracyclin repressor-like, C-terminal domain; This is the C-terminal domain present in ...
 87-177 5.00e-11

Tetracyclin repressor-like, C-terminal domain; This is the C-terminal domain present in putative TetR transcriptional regulators.


Pssm-ID: 436155  Cd Length: 106  Bit Score: 57.56  E-value: 5.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516730510   87 AASRLKETALGQHRLMLRARHGDSQMFDLIVLAAEGNWPSFRDHLKRLQAYVGELVATGIATEEFAPRNVDTAAACFCAS 166
Cdd:pfam17935   1 APERLREWLLRLFRAKRRKALDDPELFATYVVLIEEALEVVAAHIDLLDGQLAEIIREGVADGEFTAADPAAAARAVFDA 80

                          90
                  ....*....|.
gi 516730510  167 IISLWDPRIIG 177
Cdd:pfam17935  81 TARFHHPAHAA 91
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
19-167 4.06e-08

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 50.67  E-value: 4.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516730510  19 IIEAGTAACRLYGLSKTNVVDIARLLGKSPASVYKIFPSKAAIWDAIAGNFFEtDLCFTPSAGGELTSAASRLKETALGQ 98
Cdd:COG1309   11 ILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLE-ELLAALEEALAAEDPRERLRALLRAY 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516730510  99 HRLMLRARHGDSQMFDLIVLAAEGnWPSFRDHLKRLQAYVGELVATGiatEEFAPRNVDTAAACFCASI 167
Cdd:COG1309   90 LEFLAENPALARLLLAEAAELPEL-RAALRALLRRLRALLAELLRAG---GLLADVDPDALARALLALL 154
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
19-65 8.86e-03

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 33.15  E-value: 8.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 516730510   19 IIEAGTAACRLYGLSKTNVVDIARLLGKSPASVYKIFPSKAAIWDAI 65
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
TetR_C_27 pfam17935
Tetracyclin repressor-like, C-terminal domain; This is the C-terminal domain present in ...
 87-177 5.00e-11

Tetracyclin repressor-like, C-terminal domain; This is the C-terminal domain present in putative TetR transcriptional regulators.


Pssm-ID: 436155  Cd Length: 106  Bit Score: 57.56  E-value: 5.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516730510   87 AASRLKETALGQHRLMLRARHGDSQMFDLIVLAAEGNWPSFRDHLKRLQAYVGELVATGIATEEFAPRNVDTAAACFCAS 166
Cdd:pfam17935   1 APERLREWLLRLFRAKRRKALDDPELFATYVVLIEEALEVVAAHIDLLDGQLAEIIREGVADGEFTAADPAAAARAVFDA 80

                          90
                  ....*....|.
gi 516730510  167 IISLWDPRIIG 177
Cdd:pfam17935  81 TARFHHPAHAA 91
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
19-167 4.06e-08

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 50.67  E-value: 4.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516730510  19 IIEAGTAACRLYGLSKTNVVDIARLLGKSPASVYKIFPSKAAIWDAIAGNFFEtDLCFTPSAGGELTSAASRLKETALGQ 98
Cdd:COG1309   11 ILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLE-ELLAALEEALAAEDPRERLRALLRAY 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516730510  99 HRLMLRARHGDSQMFDLIVLAAEGnWPSFRDHLKRLQAYVGELVATGiatEEFAPRNVDTAAACFCASI 167
Cdd:COG1309   90 LEFLAENPALARLLLAEAAELPEL-RAALRALLRRLRALLAELLRAG---GLLADVDPDALARALLALL 154
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
19-65 8.86e-03

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 33.15  E-value: 8.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 516730510   19 IIEAGTAACRLYGLSKTNVVDIARLLGKSPASVYKIFPSKAAIWDAI 65
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH