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Conserved domains on  [gi|516925329|ref|WP_018169134|]
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NAD(P)/FAD-dependent oxidoreductase [Thioalkalivibrio sp. ALMg9]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11428914)

NAD(P)/FAD-dependent oxidoreductase similar to digeranylgeranylglycerophospholipid reductase, menaquinone reductase, tryptophan 2-halogenase, and protein FixC

CATH:  3.50.50.60|3.40.50.720|3.30.9.10
EC:  1.-.-.-
Gene Ontology:  GO:0000166|GO:0071949|GO:0016491
PubMed:  30945211
SCOP:  3000055

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
6-342 8.86e-57

Dehydrogenase (flavoprotein) [Energy production and conversion];


:

Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 188.64  E-value: 8.86e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   6 GGPAGSTVASRLAQKGRDVVLLEKARHPRFHI-GESLLPMNMPLFEELGVAEAIAAigiPKHGAEFTIPEAPdaprtyyf 84
Cdd:COG0644    1 AGPAGSAAARRLARAGLSVLLLEKGSFPGDKIcGGGLLPRALEELEPLGLDEPLER---PVRGARFYSPGGK-------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  85 ERALNDDTPASACeVRRSEFDHLLLENSARLGVRVLEEVTVFDVALadpaKGGTQQVTARDASgntlEFEADFVVDASGR 164
Cdd:COG0644   70 SVELPPGRGGGYV-VDRARFDRWLAEQAEEAGAEVRTGTRVTDVLR----DDGRVVVRTGDGE----EIRADYVVDADGA 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329 165 DTFLARRLGLKARN--PEHNSAAIFGHFnNVPRRAGRDAGNISIYW---FQHGWIWMIPLRDGAMSVGavcfpeylktrk 239
Cdd:COG0644  141 RSLLARKLGLKRRSdePQDYALAIKEHW-ELPPLEGVDPGAVEFFFgegAPGGYGWVFPLGDGRVSVG------------ 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329 240 tkpetflwdtlklcppafermqgaelagpvnatGNFSYRSSQAHGPGYLLVGDAFTFVDPVFSSGVYIAMSGGFRAADAV 319
Cdd:COG0644  208 ---------------------------------IPLGGPRPRLVGDGVLLVGDAAGFVDPLTGEGIHLAMKSGRLAAEAI 254

                        330       340
                 ....*....|....*....|...
gi 516925329 320 DRCLEHPARSARYLRAFERDVRR 342
Cdd:COG0644  255 AEALEGGDFSAEALAEYERRLRE 277
 
Name Accession Description Interval E-value
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
6-342 8.86e-57

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 188.64  E-value: 8.86e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   6 GGPAGSTVASRLAQKGRDVVLLEKARHPRFHI-GESLLPMNMPLFEELGVAEAIAAigiPKHGAEFTIPEAPdaprtyyf 84
Cdd:COG0644    1 AGPAGSAAARRLARAGLSVLLLEKGSFPGDKIcGGGLLPRALEELEPLGLDEPLER---PVRGARFYSPGGK-------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  85 ERALNDDTPASACeVRRSEFDHLLLENSARLGVRVLEEVTVFDVALadpaKGGTQQVTARDASgntlEFEADFVVDASGR 164
Cdd:COG0644   70 SVELPPGRGGGYV-VDRARFDRWLAEQAEEAGAEVRTGTRVTDVLR----DDGRVVVRTGDGE----EIRADYVVDADGA 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329 165 DTFLARRLGLKARN--PEHNSAAIFGHFnNVPRRAGRDAGNISIYW---FQHGWIWMIPLRDGAMSVGavcfpeylktrk 239
Cdd:COG0644  141 RSLLARKLGLKRRSdePQDYALAIKEHW-ELPPLEGVDPGAVEFFFgegAPGGYGWVFPLGDGRVSVG------------ 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329 240 tkpetflwdtlklcppafermqgaelagpvnatGNFSYRSSQAHGPGYLLVGDAFTFVDPVFSSGVYIAMSGGFRAADAV 319
Cdd:COG0644  208 ---------------------------------IPLGGPRPRLVGDGVLLVGDAAGFVDPLTGEGIHLAMKSGRLAAEAI 254

                        330       340
                 ....*....|....*....|...
gi 516925329 320 DRCLEHPARSARYLRAFERDVRR 342
Cdd:COG0644  255 AEALEGGDFSAEALAEYERRLRE 277
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 2-319 1.57e-26

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 108.18  E-value: 1.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329    2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHPRFHI-GESLLPMNMPLFEELGVAEAiaaigIPKHGAEFTIPEAPdapr 80
Cdd:TIGR02032   4 VVVGAGPAGASAAYRLADKGLRVLLLEKKSFPRYKPcGGALSPRALEELDLPGELIV-----NLVRGARFFSPNGD---- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   81 tyyFERALNDDTPASAceVRRSEFDHLLLENSARLGVRVLEEVTVFDValadPAKGGTQQVTARDASGntlEFEADFVVD 160
Cdd:TIGR02032  75 ---SVEIPIETELAYV--IDRDAFDEQLAERAQEAGAELRLGTRVLDV----EIHDDRVVVIVRGSEG---TVTAKIVIG 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  161 ASGRDTFLARRLGLKARNPEHNSAA-IFGHFNNVPRRagRDAGNISIYW--FQHGWIWMIPLRDGAMSVG-AVCFPEYLK 236
Cdd:TIGR02032 143 ADGSRSIVAKKLGLKKEPREYGVAArAEVEMPDEEVD--EDFVEVYIDRgiVPGGYGWVFPKGDGTANVGvGSRSAEEGE 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  237 TRKTKPETFLWDTlklcpPAFERMQGAELAGPVNATGNFsyrSSQAHGPGYLLVGDAFTFVDPVFSSGVYIAMSGGFRAA 316
Cdd:TIGR02032 221 DPKKYLKDFLARR-----PELKDAETVEVCGALIPIGRP---DEKLVRGNVLLVGDAAGHVNPLTGEGIYYAMRSGDIAA 292


                  ...
gi 516925329  317 DAV 319
Cdd:TIGR02032 293 EVV 295
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 2-251 1.59e-14

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 74.28  E-value: 1.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329    2 VVIGGGPAGSTVASRLAQKGRDVVLLEK----ARHPRFHIgesLLPMNMPLFEELGVAEAIAAIGIPKHGAEFTIpEAPD 77
Cdd:pfam01494   5 LIVGGGPAGLMLALLLARAGVRVVLVERhattSVLPRAHG---LNQRTMELLRQAGLEDRILAEGVPHEGMGLAF-YNTR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   78 APRTYYFeralnDDTPASACEVRRSEFDHLLLENSARLGVRVLEEVTVfdvaLADPAKGGTQQVTARD-ASGNTLEFEAD 156
Cdd:pfam01494  81 RRADLDF-----LTSPPRVTVYPQTELEPILVEHAEARGAQVRFGTEV----LSLEQDGDGVTAVVRDrRDGEEYTVRAK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  157 FVVDASGRDTFLARRLGLKARNPEHNSAAIFGHFNNVPRRAGRDAGNISIYW--FQHGWIWMIPLRDGAMSVGAVCFPEY 234
Cdd:pfam01494 152 YLVGCDGGRSPVRKTLGIEFEGFEGVPFGSLDVLFDAPDLSDPVERAFVHYLiyAPHSRGFMVGPWRSAGRERYYVQVPW 231

                         250
                  ....*....|....*..
gi 516925329  235 LKTRKTKPETFLWDTLK 251
Cdd:pfam01494 232 DEEVEERPEEFTDEELK 248
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
2-174 7.21e-11

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 63.77  E-value: 7.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARH----PR-FHI-GESllpmnMPLFEELGVAEAIAAIGIPKHG-------- 67
Cdd:PRK06183  14 VIVGAGPVGLTLANLLGQYGVRVLVLERWPTlydlPRaVGIdDEA-----LRVLQAIGLADEVLPHTTPNHGmrfldakg 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  68 ---AEFTIPEAPDA--PRTYYFeralndDTPasacevrrsEFDHLLLENSARL-GVRVLEEVTVfdVALADPAKGGTqqV 141
Cdd:PRK06183  89 rclAEIARPSTGEFgwPRRNAF------HQP---------LLEAVLRAGLARFpHVRVRFGHEV--TALTQDDDGVT--V 149

                        170       180       190
                 ....*....|....*....|....*....|...
gi 516925329 142 TARDASGNTLEFEADFVVDASGRDTFLARRLGL 174
Cdd:PRK06183 150 TLTDADGQRETVRARYVVGCDGANSFVRRTLGV 182
 
Name Accession Description Interval E-value
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
6-342 8.86e-57

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 188.64  E-value: 8.86e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   6 GGPAGSTVASRLAQKGRDVVLLEKARHPRFHI-GESLLPMNMPLFEELGVAEAIAAigiPKHGAEFTIPEAPdaprtyyf 84
Cdd:COG0644    1 AGPAGSAAARRLARAGLSVLLLEKGSFPGDKIcGGGLLPRALEELEPLGLDEPLER---PVRGARFYSPGGK-------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  85 ERALNDDTPASACeVRRSEFDHLLLENSARLGVRVLEEVTVFDVALadpaKGGTQQVTARDASgntlEFEADFVVDASGR 164
Cdd:COG0644   70 SVELPPGRGGGYV-VDRARFDRWLAEQAEEAGAEVRTGTRVTDVLR----DDGRVVVRTGDGE----EIRADYVVDADGA 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329 165 DTFLARRLGLKARN--PEHNSAAIFGHFnNVPRRAGRDAGNISIYW---FQHGWIWMIPLRDGAMSVGavcfpeylktrk 239
Cdd:COG0644  141 RSLLARKLGLKRRSdePQDYALAIKEHW-ELPPLEGVDPGAVEFFFgegAPGGYGWVFPLGDGRVSVG------------ 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329 240 tkpetflwdtlklcppafermqgaelagpvnatGNFSYRSSQAHGPGYLLVGDAFTFVDPVFSSGVYIAMSGGFRAADAV 319
Cdd:COG0644  208 ---------------------------------IPLGGPRPRLVGDGVLLVGDAAGFVDPLTGEGIHLAMKSGRLAAEAI 254

                        330       340
                 ....*....|....*....|...
gi 516925329 320 DRCLEHPARSARYLRAFERDVRR 342
Cdd:COG0644  255 AEALEGGDFSAEALAEYERRLRE 277
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 2-319 1.57e-26

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 108.18  E-value: 1.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329    2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHPRFHI-GESLLPMNMPLFEELGVAEAiaaigIPKHGAEFTIPEAPdapr 80
Cdd:TIGR02032   4 VVVGAGPAGASAAYRLADKGLRVLLLEKKSFPRYKPcGGALSPRALEELDLPGELIV-----NLVRGARFFSPNGD---- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   81 tyyFERALNDDTPASAceVRRSEFDHLLLENSARLGVRVLEEVTVFDValadPAKGGTQQVTARDASGntlEFEADFVVD 160
Cdd:TIGR02032  75 ---SVEIPIETELAYV--IDRDAFDEQLAERAQEAGAELRLGTRVLDV----EIHDDRVVVIVRGSEG---TVTAKIVIG 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  161 ASGRDTFLARRLGLKARNPEHNSAA-IFGHFNNVPRRagRDAGNISIYW--FQHGWIWMIPLRDGAMSVG-AVCFPEYLK 236
Cdd:TIGR02032 143 ADGSRSIVAKKLGLKKEPREYGVAArAEVEMPDEEVD--EDFVEVYIDRgiVPGGYGWVFPKGDGTANVGvGSRSAEEGE 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  237 TRKTKPETFLWDTlklcpPAFERMQGAELAGPVNATGNFsyrSSQAHGPGYLLVGDAFTFVDPVFSSGVYIAMSGGFRAA 316
Cdd:TIGR02032 221 DPKKYLKDFLARR-----PELKDAETVEVCGALIPIGRP---DEKLVRGNVLLVGDAAGHVNPLTGEGIYYAMRSGDIAA 292


                  ...
gi 516925329  317 DAV 319
Cdd:TIGR02032 293 EVV 295
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 2-190 1.81e-18

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 85.76  E-value: 1.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHPRFHI-GESLLPMNMPLFEELGVAEAIAAIGIPKHGAEFTIpeapDAPR 80
Cdd:COG0654    7 LIVGGGPAGLALALALARAGIRVTVVERAPPPRPDGrGIALSPRSLELLRRLGLWDRLLARGAPIRGIRVRD----GSDG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  81 TYYFERALNDDTPASACEVRRSEFDHLLLENSARLGVRVLEEVTVFDVALADpakggtQQVTARDASGNTLefEADFVVD 160
Cdd:COG0654   83 RVLARFDAAETGLPAGLVVPRADLERALLEAARALGVELRFGTEVTGLEQDA------DGVTVTLADGRTL--RADLVVG 154

                        170       180       190
                 ....*....|....*....|....*....|
gi 516925329 161 ASGRDTFLARRLGLKARNPEHNSAAIFGHF 190
Cdd:COG0654  155 ADGARSAVRRLLGIGFTGRDYPQRALWAGV 184
FAD_binding_3 pfam01494
FAD binding domain; This domain is involved in FAD binding in a number of enzymes.
 2-251 1.59e-14

FAD binding domain; This domain is involved in FAD binding in a number of enzymes.


Pssm-ID: 396193 [Multi-domain]  Cd Length: 348  Bit Score: 74.28  E-value: 1.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329    2 VVIGGGPAGSTVASRLAQKGRDVVLLEK----ARHPRFHIgesLLPMNMPLFEELGVAEAIAAIGIPKHGAEFTIpEAPD 77
Cdd:pfam01494   5 LIVGGGPAGLMLALLLARAGVRVVLVERhattSVLPRAHG---LNQRTMELLRQAGLEDRILAEGVPHEGMGLAF-YNTR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   78 APRTYYFeralnDDTPASACEVRRSEFDHLLLENSARLGVRVLEEVTVfdvaLADPAKGGTQQVTARD-ASGNTLEFEAD 156
Cdd:pfam01494  81 RRADLDF-----LTSPPRVTVYPQTELEPILVEHAEARGAQVRFGTEV----LSLEQDGDGVTAVVRDrRDGEEYTVRAK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  157 FVVDASGRDTFLARRLGLKARNPEHNSAAIFGHFNNVPRRAGRDAGNISIYW--FQHGWIWMIPLRDGAMSVGAVCFPEY 234
Cdd:pfam01494 152 YLVGCDGGRSPVRKTLGIEFEGFEGVPFGSLDVLFDAPDLSDPVERAFVHYLiyAPHSRGFMVGPWRSAGRERYYVQVPW 231

                         250
                  ....*....|....*..
gi 516925329  235 LKTRKTKPETFLWDTLK 251
Cdd:pfam01494 232 DEEVEERPEEFTDEELK 248
Trp_halogenase pfam04820
Tryptophan halogenase; Tryptophan halogenase catalyzes the chlorination of tryptophan to form ...
 2-351 5.53e-13

Tryptophan halogenase; Tryptophan halogenase catalyzes the chlorination of tryptophan to form 7-chlorotryptophan. This is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. Tryptophan halogenase is NADH-dependent.


Pssm-ID: 398475 [Multi-domain]  Cd Length: 457  Bit Score: 70.44  E-value: 5.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329    2 VVIGGGPAGSTVASRLA---QKGRDVVLLEKARHPRFHIGESLLPMNMPLFEELGVAEAI---AAIGIPKHGAEF----T 71
Cdd:pfam04820   3 VIVGGGTAGWMAAAALAralKGGLDVTLVESEEIGTVGVGEATIPSIRTFNRMLGIDEAEflrATQATFKLGIRFedwgR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   72 IPEA----------------------------PDAPRTYY-----------FERALNDDTP-----ASACEVRRSEFDHL 107
Cdd:pfam04820  83 RGERyihpfgvtghpidgvpfhhywlrlrargFAGPLDDYclpavaalagkFSPPPKDPRSglsglSYAYHFDAALYARF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  108 LLENSARLGVRVLEEVTVfDVALadpakGGTQQVTA-RDASGNtlEFEADFVVDASG-RDTFLARRLGLKARN-----PE 180
Cdd:pfam04820 163 LRRNAEARGVTRVEGKVV-DVQL-----DADGFVTSlRLEDGR--EVEADLFIDCSGfRGLLIEQALKTGYEDwsdwlPC 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  181 HNSAAIFGHFNNVPRRAGRdagniSIYwFQHGWIWMIPLRDGAMSvGAVCFPEYLkTRKTKPETFL--WDTLKLCPPAFE 258
Cdd:pfam04820 235 DRALAVQCESVGPPEPYTR-----ATA-HDAGWRWRIPLQHRLGN-GYVYSSAHA-DDDEALAELLanLGGIPLAEPRLI 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  259 RMQgaelagpvnaTGnfsyRSSQAHGPGYLLVGDAFTFVDPVFSSGVYIAMSggfraadAVDRCLEH-PARS-ARYLRA- 335
Cdd:pfam04820 307 RFT----------TG----RRKQAWVKNVVALGLASGFLEPLESTSIHLIQS-------ALRRLLALfPDGGfDPAAIAe 365

                         410
                  ....*....|....*.
gi 516925329  336 FERDVRRGVRRFSWLI 351
Cdd:pfam04820 366 YNRRIAREYERIRDFI 381
mhpA PRK06183
bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
2-174 7.21e-11

bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;


Pssm-ID: 235727 [Multi-domain]  Cd Length: 500  Bit Score: 63.77  E-value: 7.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARH----PR-FHI-GESllpmnMPLFEELGVAEAIAAIGIPKHG-------- 67
Cdd:PRK06183  14 VIVGAGPVGLTLANLLGQYGVRVLVLERWPTlydlPRaVGIdDEA-----LRVLQAIGLADEVLPHTTPNHGmrfldakg 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  68 ---AEFTIPEAPDA--PRTYYFeralndDTPasacevrrsEFDHLLLENSARL-GVRVLEEVTVfdVALADPAKGGTqqV 141
Cdd:PRK06183  89 rclAEIARPSTGEFgwPRRNAF------HQP---------LLEAVLRAGLARFpHVRVRFGHEV--TALTQDDDGVT--V 149

                        170       180       190
                 ....*....|....*....|....*....|...
gi 516925329 142 TARDASGNTLEFEADFVVDASGRDTFLARRLGL 174
Cdd:PRK06183 150 TLTDADGQRETVRARYVVGCDGANSFVRRTLGV 182
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 2-101 4.10e-07

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 52.16  E-value: 4.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHP------------RFHIGESLLPMNM---PLFEELGVAEAIAAIGIP-- 64
Cdd:COG1233    7 VVIGAGIGGLAAAALLARAGYRVTVLEKNDTPggrartferpgfRFDVGPSVLTMPGvleRLFRELGLEDYLELVPLDpa 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 516925329  65 -----KHGAEFTIPEAPDAprtyyFERALNDDTPASACEVRR 101
Cdd:COG1233   87 yrvpfPDGRALDLPRDLER-----TAAELERLFPGDAEAYRR 123
PRK06185 PRK06185
FAD-dependent oxidoreductase;
2-342 4.29e-07

FAD-dependent oxidoreductase;


Pssm-ID: 235729 [Multi-domain]  Cd Length: 407  Bit Score: 51.78  E-value: 4.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKarHPRF---HIGESLLPMNMPLFEELGVAEAIAAIGIPK-HGAEFTIPEapd 77
Cdd:PRK06185  10 CIVGGGPAGMMLGLLLARAGVDVTVLEK--HADFlrdFRGDTVHPSTLELMDELGLLERFLELPHQKvRTLRFEIGG--- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  78 apRTYY---FERaLNDDTPASAcEVRRSEFDHLLLENSARL-GVRVLEEVTVFDVALADpakGGTQQVTARDASGnTLEF 153
Cdd:PRK06185  85 --RTVTladFSR-LPTPYPYIA-MMPQWDFLDFLAEEASAYpNFTLRMGAEVTGLIEEG---GRVTGVRARTPDG-PGEI 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329 154 EADFVVDASGRDTFLARRLGLKARNpehnsaaiFGH------FnNVPRRAGRDAGNISIYWFQHGWIwMIPlRDGAMSVG 227
Cdd:PRK06185 157 RADLVVGADGRHSRVRALAGLEVRE--------FGApmdvlwF-RLPREPDDPESLMGRFGPGQGLI-MID-RGDYWQCG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329 228 AVcFP--EYLKTRKTKPETFLWDTLKLCPpafermqgaELAGPVNATGNFS---------YRSSQAHGPGYLLVGDAFTF 296
Cdd:PRK06185 226 YV-IPkgGYAALRAAGLEAFRERVAELAP---------ELADRVAELKSWDdvklldvrvDRLRRWHRPGLLCIGDAAHA 295

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 516925329 297 VDPVFSSGVYIAMSGGFRAADAVDRCLEHPARSARYLRAFERdvRR 342
Cdd:PRK06185 296 MSPVGGVGINLAIQDAVAAANILAEPLRRGRVSDRDLAAVQR--RR 339
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
3-33 1.11e-06

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 45.60  E-value: 1.11e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 516925329    3 VIGGGPAGSTVASRLAQKGRDVVLLEKARHP 33
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRL 31
PTZ00367 PTZ00367
squalene epoxidase; Provisional
 2-67 9.71e-06

squalene epoxidase; Provisional


Pssm-ID: 240384 [Multi-domain]  Cd Length: 567  Bit Score: 47.92  E-value: 9.71e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKA--RHPRFHIGESLLPMNMPLFEELGVAEAIAAIGIPKHG 67
Cdd:PTZ00367  37 IIVGGSIAGPVLAKALSKQGRKVLMLERDlfSKPDRIVGELLQPGGVNALKELGMEECAEGIGMPCFG 104
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 2-31 1.24e-05

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 47.39  E-value: 1.24e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKAR 31
Cdd:COG1249    7 VVIGAGPGGYVAAIRAAQLGLKVALVEKGR 36
PRK07608 PRK07608
UbiH/UbiF family hydroxylase;
2-225 5.15e-05

UbiH/UbiF family hydroxylase;


Pssm-ID: 181057 [Multi-domain]  Cd Length: 388  Bit Score: 45.33  E-value: 5.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEkARHPRFHIGES-------LLPMNMPLFEELGVAEAIAAIGIPK------HGa 68
Cdd:PRK07608   9 VVVGGGLVGASLALALAQSGLRVALLA-PRAPPRPADDAwdsrvyaISPSSQAFLERLGVWQALDAARLAPvydmrvFG- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  69 eftipeapDAPRTYYFErALNDDTPASACEVRRSEFDHLLLENsarlgVRVLEEVTVFDvALADPAKGGTQQVTARDASG 148
Cdd:PRK07608  87 --------DAHARLHFS-AYQAGVPQLAWIVESSLIERALWAA-----LRFQPNLTWFP-ARAQGLEVDPDAATLTLADG 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516925329 149 NTLefEADFVVDASGRDTFLARRLGLKARNPEHNSAAIFGHFNnvprrAGRDAGNISIYWFQHGWIW-MIPLRDGAMS 225
Cdd:PRK07608 152 QVL--RADLVVGADGAHSWVRSQAGIKAERRPYRQTGVVANFK-----AERPHRGTAYQWFRDDGILaLLPLPDGHVS 222
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
2-33 5.22e-05

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 45.04  E-value: 5.22e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHP 33
Cdd:COG2081    1 IVIGAGAAGLMAAITAAERGARVLLLEKNPKV 32
PRK06126 PRK06126
hypothetical protein; Provisional
 2-173 6.73e-05

hypothetical protein; Provisional


Pssm-ID: 235704 [Multi-domain]  Cd Length: 545  Bit Score: 44.98  E-value: 6.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHPRFHIGESLLPM-NMPLFEELGVAEAIAAIGIPKH------------GA 68
Cdd:PRK06126  11 LIVGGGPVGLALALDLGRRGVDSILVERKDGTAFNPKANTTSArSMEHFRRLGIADEVRSAGLPVDyptdiayftrltGY 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  69 E---FTIPEAPDAPrTYYFERALNDDTPASACEVRRSEFDHLLLENSARL-GVRVLEEVTVFDValADPAKGGTqqVTAR 144
Cdd:PRK06126  91 ElarFRLPSAREAI-TPVGGPDGSWPSPELPHRIPQKYLEPILLEHAAAQpGVTLRYGHRLTDF--EQDADGVT--ATVE 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 516925329 145 D-ASGNTLEFEADFVVDASGRDTFLARRLG 173
Cdd:PRK06126 166 DlDGGESLTIRADYLVGCDGARSAVRRSLG 195
PRK10015 PRK10015
oxidoreductase; Provisional
 2-186 7.02e-05

oxidoreductase; Provisional


Pssm-ID: 182194 [Multi-domain]  Cd Length: 429  Bit Score: 44.97  E-value: 7.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKarhprfhiGESLLPMNMP---LFeelgvAEAIAAIgIPKHGAEFTIPE---- 74
Cdd:PRK10015   9 IVVGAGVAGSVAALVMARAGLDVLVIER--------GDSAGCKNMTggrLY-----AHTLEAI-IPGFAASAPVERkvtr 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  75 ------APDAPRTYYFERALNDDTPASACEVRRSEFDHLLLENSARLGVRVLEEVTVfdvalaDPAKGGTQQVTARDASG 148
Cdd:PRK10015  75 ekisflTEESAVTLDFHREQPDVPQHASYTVLRNRLDPWLMEQAEQAGAQFIPGVRV------DALVREGNKVTGVQAGD 148

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 516925329 149 NTLefEADFVVDASGRDTFLARRLGL-KARNPEHNSAAI 186
Cdd:PRK10015 149 DIL--EANVVILADGVNSMLGRSLGMvPASDPHHYAVGV 185
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 2-58 8.15e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 44.82  E-value: 8.15e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHP------------RFHIG-ESLLPMN---MPLFEELGVAEAI 58
Cdd:COG1232    5 AVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVgglirtvevdgfRIDRGpHSFLTRDpevLELLRELGLGDEL 77
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 2-37 9.77e-05

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 44.43  E-value: 9.77e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQ-KGRDVVLLE---KARHPRFHI 37
Cdd:COG2303    8 VIVGAGSAGCVLANRLSEdAGLRVLLLEaggRDDDPLIRM 47
PRK07538 PRK07538
hypothetical protein; Provisional
 2-163 1.03e-04

hypothetical protein; Provisional


Pssm-ID: 236046 [Multi-domain]  Cd Length: 413  Bit Score: 44.50  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHPR-FHIGESLLPMNMPLFEELGVAEAIAAIGIP--------KHGAEFTi 72
Cdd:PRK07538   4 LIAGGGIGGLTLALTLHQRGIEVVVFEAAPELRpLGVGINLLPHAVRELAELGLLDALDAIGIRtrelayfnRHGQRIW- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  73 peapDAPRTyyfeRALNDDTPASAceVRRSEFdHLLLENSA--RLG---VRVLEEVTVFdvalaDPAKGGTQQVTARDAS 147
Cdd:PRK07538  83 ----SEPRG----LAAGYDWPQYS--IHRGEL-QMLLLDAVreRLGpdaVRTGHRVVGF-----EQDADVTVVFLGDRAG 146

                        170
                 ....*....|....*.
gi 516925329 148 GNTLEFEADFVVDASG 163
Cdd:PRK07538 147 GDLVSVRGDVLIGADG 162
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
2-31 2.23e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 42.97  E-value: 2.23e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKAR 31
Cdd:COG0665    6 VVIGGGIAGLSTAYHLARRGLDVTVLERGR 35
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 3-32 2.68e-04

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 43.24  E-value: 2.68e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 516925329   3 VIGGGPAGSTVASRLAQKGRDVVLLEkARH 32
Cdd:PRK11749 145 VIGAGPAGLTAAHRLARKGYDVTIFE-ARD 173
HI0933_like pfam03486
HI0933-like protein;
2-33 2.72e-04

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 42.95  E-value: 2.72e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 516925329    2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHP 33
Cdd:pfam03486   4 IVIGGGAAGLMAAISAAKRGRRVLLIEKGKKL 35
FAD_oxidored pfam12831
FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases ...
 2-163 3.42e-04

FAD dependent oxidoreductase; This family of proteins contains FAD dependent oxidoreductases and related proteins.


Pssm-ID: 432816 [Multi-domain]  Cd Length: 420  Bit Score: 42.60  E-value: 3.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329    2 VVIGGGPAGSTVASRLAQKGRDVVLLEkarhPRFHIG-----ESLLPMNMPLFEEL----GVAEAIAAiGIPKHGAEFTI 72
Cdd:pfam12831   3 VVVGGGPAGVAAAIAAARAGAKVLLVE----RRGFLGgmltsGLVGPDMGFYLNKEqvvgGIAREFRQ-RLRARGGLPGP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   73 PEAPDAPRTYYFERALnddtpasacEVrrseFDHLLLENsarlGVRVLEEVTVFDVALADpakGGTQQVTARDASGnTLE 152
Cdd:pfam12831  78 YGLRGGWVPFDPEVAK---------AV----LDEMLAEA----GVTVLLHTRVVGVVKEG---GRITGVTVETKGG-RIT 136

                         170
                  ....*....|.
gi 516925329  153 FEADFVVDASG 163
Cdd:pfam12831 137 IRAKVFIDATG 147
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 2-32 3.67e-04

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 42.31  E-value: 3.67e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 516925329    2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARH 32
Cdd:pfam07992   4 VVIGGGPAGLAAALTLAQLGGKVTLIEDEGT 34
PRK07494 PRK07494
UbiH/UbiF family hydroxylase;
2-189 3.92e-04

UbiH/UbiF family hydroxylase;


Pssm-ID: 181001 [Multi-domain]  Cd Length: 388  Bit Score: 42.58  E-value: 3.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEkarhPRFHIGE----SLLPMNMPLFEELGVAEAIAaigipKHGAEFTIPEAPD 77
Cdd:PRK07494  11 AVIGGGPAGLAAAIALARAGASVALVA----PEPPYADlrttALLGPSIRFLERLGLWARLA-----PHAAPLQSMRIVD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  78 A------PRTYYFeralnddtpaSACEVRRSEFDH------LLLENSARlgVRVLEEVTVFDVALADPAKGGTqQVTARD 145
Cdd:PRK07494  82 AtgrlirAPEVRF----------RAAEIGEDAFGYnipnwlLNRALEAR--VAELPNITRFGDEAESVRPRED-EVTVTL 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 516925329 146 ASGNTLefEADFVVDASGRDTFLARRLGLKARNPEHNSAAI---FGH 189
Cdd:PRK07494 149 ADGTTL--SARLVVGADGRNSPVREAAGIGVRTWSYPQKALvlnFTH 193
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 2-232 4.26e-04

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 42.51  E-value: 4.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHPRfhiGESLL---PMNMP---------------LFEEL----------G 53
Cdd:COG1053    7 VVVGSGGAGLRAALEAAEAGLKVLVLEKVPPRG---GHTAAaqgGINAAgtnvqkaagedspeeHFYDTvkggdgladqD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  54 VAEAIAAIGIP------KHGAEFTIPEAPDAPRT--YYFERalnddtpasACEVRRS---EFDHLLLENSARLGVRVLEE 122
Cdd:COG1053   84 LVEALAEEAPEaidwleAQGVPFSRTPDGRLPQFggHSVGR---------TCYAGDGtghALLATLYQAALRLGVEIFTE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329 123 VTVFDVALADPA-KGgtqqVTARDASGNTLEFEADFVVDASG--------RDTFLARRLGLKARNPEHN--SAAIFGHfn 191
Cdd:COG1053  155 TEVLDLIVDDGRvVG----VVARDRTGEIVRIRAKAVVLATGgfgrnyemRAEYLPEAEGALSTNAPGNtgDGIAMAL-- 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 516925329 192 nvprRAGRDAGNISIYWFqHGWIwmIPLRDGAMSVGAVCFP 232
Cdd:COG1053  229 ----RAGAALADMEFVQF-HPTG--LPGDGGLISEGARGKP 262
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 2-36 4.45e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 42.00  E-value: 4.45e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 516925329    2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHPRFH 36
Cdd:pfam01266   3 VVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSG 37
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 2-29 5.90e-04

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 42.09  E-value: 5.90e-04
                         10        20
                 ....*....|....*....|....*...
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEK 29
Cdd:PRK06292   7 IVIGAGPAGYVAARRAAKLGKKVALIEK 34
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
3-29 6.52e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 42.15  E-value: 6.52e-04
                         10        20
                 ....*....|....*....|....*..
gi 516925329   3 VIGGGPAGSTVASRLAQKGRDVVLLEK 29
Cdd:COG1148  145 VIGGGIAGMTAALELAEQGYEVYLVEK 171
PRK07233 PRK07233
hypothetical protein; Provisional
 2-58 7.81e-04

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 41.41  E-value: 7.81e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHP---------------RF--HIGESLLPMnMPLFEELGVAEAI 58
Cdd:PRK07233   3 AIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLgglaasfefgglpieRFyhHIFKSDEAL-LELLDELGLEDKL 75
PRK07208 PRK07208
hypothetical protein; Provisional
 2-32 9.00e-04

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 41.41  E-value: 9.00e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARH 32
Cdd:PRK07208   8 VIIGAGPAGLTAAYELLKRGYPVTVLEADPV 38
PRK09126 PRK09126
FAD-dependent hydroxylase;
2-345 9.08e-04

FAD-dependent hydroxylase;


Pssm-ID: 236385 [Multi-domain]  Cd Length: 392  Bit Score: 41.47  E-value: 9.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEkaRHPRFHIGE--------SLLPMNMPLFEELGVAEAIAAIGI-PKHGAEFti 72
Cdd:PRK09126   7 VVVGAGPAGLSFARSLAGSGLKVTLIE--RQPLAALADpafdgreiALTHASREILQRLGAWDRIPEDEIsPLRDAKV-- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329  73 pEAPDAPRTYYFERALNDDTP----ASACEVRRSEFDhlllENSARLGVRVLEEVTVFDValadpaKGGTQQVTARDASG 148
Cdd:PRK09126  83 -LNGRSPFALTFDARGRGADAlgylVPNHLIRRAAYE----AVSQQDGIELLTGTRVTAV------RTDDDGAQVTLANG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329 149 NTLefEADFVVDASGRDTFLARRLGLkarnpehnSAAI--FGHFNNVPR-RAGRDAGNISIYWFQHGW-IWMIPLRDGAM 224
Cdd:PRK09126 152 RRL--TARLLVAADSRFSATRRQLGI--------GADMhdFGRTMLVCRmRHELPHHHTAWEWFGYGQtLALLPLNGHLS 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516925329 225 SVgavcfpeYLKTRKTKPETFlwdtLKLCPPAFERMQGAELAGPVNATGNFSYR---------SSQAHGPGYLLVGDAFT 295
Cdd:PRK09126 222 SL-------VLTLPPDQIEAL----LALDPEAFAAEVTARFKGRLGAMRLVSSRhayplvavyAHRFVAKRFALIGDAAV 290

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 516925329 296 FVDPVFSSGVYIAMSGGFRAADAVdrcLEHPAR-----SARYLRAFERDVRRGVR 345
Cdd:PRK09126 291 GMHPVTAHGFNLGLKGQDILARLI---LAAARRgqdigAASLLERYERKHRLATR 342
PRK08132 PRK08132
FAD-dependent oxidoreductase; Provisional
 2-68 1.64e-03

FAD-dependent oxidoreductase; Provisional


Pssm-ID: 236158 [Multi-domain]  Cd Length: 547  Bit Score: 40.62  E-value: 1.64e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKarHPRFHIG--------ESLlpmnmPLFEELGVAEAIAAIGIPKHGA 68
Cdd:PRK08132  27 VVVGAGPVGLALAIDLAQQGVPVVLLDD--DDTLSTGsraicfakRSL-----EIFDRLGCGERMVDKGVSWNVG 94
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 3-33 1.73e-03

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 40.50  E-value: 1.73e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 516925329   3 VIGGGPAGSTVASRLAQKGRDVVLLEKARHP 33
Cdd:COG0493  126 VVGSGPAGLAAAYQLARAGHEVTVFEALDKP 156
TIGR00275 TIGR00275
flavoprotein, HI0933 family; The model when searched with a partial length search brings in ...
 2-31 2.04e-03

flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272992 [Multi-domain]  Cd Length: 400  Bit Score: 40.27  E-value: 2.04e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 516925329    2 VVIGGGPAGSTVASRLAQKGRDVVLLEKAR 31
Cdd:TIGR00275   1 IIIGGGAAGLMAAITAARAGLSVLLLEKNK 30
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 2-31 2.39e-03

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 39.85  E-value: 2.39e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKAR 31
Cdd:COG2072   10 VVIGAGQAGLAAAYHLRRAGIDFVVLEKAD 39
PRK08243 PRK08243
4-hydroxybenzoate 3-monooxygenase; Validated
 2-70 2.52e-03

4-hydroxybenzoate 3-monooxygenase; Validated


Pssm-ID: 236198 [Multi-domain]  Cd Length: 392  Bit Score: 39.78  E-value: 2.52e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEkaRHPRFHIgES------LLPMNMPLFEELGVAEAIAAIGIPKHGAEF 70
Cdd:PRK08243   6 AIIGAGPAGLLLGQLLHLAGIDSVVLE--RRSREYV-EGriragvLEQGTVDLLREAGVGERMDREGLVHDGIEL 77
lipoamide_DH TIGR01350
dihydrolipoamide dehydrogenase; This model describes dihydrolipoamide dehydrogenase, a ...
 2-29 3.45e-03

dihydrolipoamide dehydrogenase; This model describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide.


Pssm-ID: 273568 [Multi-domain]  Cd Length: 460  Bit Score: 39.55  E-value: 3.45e-03
                          10        20
                  ....*....|....*....|....*...
gi 516925329    2 VVIGGGPAGSTVASRLAQKGRDVVLLEK 29
Cdd:TIGR01350   5 IVIGGGPGGYVAAIRAAQLGLKVALVEK 32
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 3-38 3.47e-03

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 39.76  E-value: 3.47e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 516925329   3 VIGGGPAGSTVASRLAQKGRDVVLLEkaRHPRfhIG 38
Cdd:PRK12810 148 VVGSGPAGLAAADQLARAGHKVTVFE--RADR--IG 179
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 2-33 4.44e-03

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 39.07  E-value: 4.44e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 516925329   2 VVIGGGPAGSTVASRLAQKGRDVVLLEKARHP 33
Cdd:COG3349    7 VVVGGGLAGLAAAVELAEAGFRVTLLEARPRL 38
PLN00093 PLN00093
geranylgeranyl diphosphate reductase; Provisional
 3-29 8.47e-03

geranylgeranyl diphosphate reductase; Provisional


Pssm-ID: 177713 [Multi-domain]  Cd Length: 450  Bit Score: 38.19  E-value: 8.47e-03
                         10        20
                 ....*....|....*....|....*..
gi 516925329   3 VIGGGPAGSTVASRLAQKGRDVVLLEK 29
Cdd:PLN00093  44 VIGGGPAGACAAETLAKGGIETFLIER 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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