|
Name |
Accession |
Description |
Interval |
E-value |
| NagC |
COG1940 |
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
78-374 |
1.21e-44 |
|
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];
Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 156.98 E-value: 1.21e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 78 RRDCGYLIVVIISSDAVQYSLVDYAGKLIDRFSEErSHDPAGAGRFVAAVRAGLLRILDRSKISQEKVLLISISSKGLVN 157
Cdd:COG1940 1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIP-TPAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 158 STEPVLVWSPIFGS-DQIDFESALRPEWQAKVILDNETllVAAALGareEMVKGA--DFRSLAALSLGHSVGLGIVRRGN 234
Cdd:COG1940 80 PETGVVLNAPNLPGwRGVPLAELLEERLGLPVFVENDA--NAAALA---EAWFGAgrGADNVVYLTLGTGIGGGIVINGK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 235 -QTGQEISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSAFEvpldtipAKFVPVAELDKIAAKARQGHRVPAFA 313
Cdd:COG1940 155 lLRGANGNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARE-------LGGAEKLTAEELFAAARAGDPLALEV 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517054360 314 FRQAGLALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQGIEEGLGQSHIVRMEGMPEIRV 374
Cdd:COG1940 228 LDEAARYLGIGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVP 288
|
|
| ASKHA_ATPase_ROK_CYANR |
cd24073 |
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ... |
82-358 |
4.17e-36 |
|
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466923 [Multi-domain] Cd Length: 304 Bit Score: 134.22 E-value: 4.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 82 GYLIVVIISSDAVQYSLVDYAGKLIDRFSEE-RSHDPAGAgrfVAAVRAGLLRILDRSKISQEKVLLISISSKGLVNSTE 160
Cdd:cd24073 1 AYVVGVKLTEDRITAVLTDLRGNVLASHTLPlDSGDPEAV---AEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAET 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 161 PVLVWSPIFGSDQIDFESALRPEWQAKVILDNETLLVAAA---LGAreemvkGADFRSLAALSLGHSVGLGIV-----RR 232
Cdd:cd24073 78 GICRWSPLLGWRDVPLAELLEERLGLPVYVENDVNALALAehwFGA------GRGLDNFAVVTIGRGIGCGLVvdgrlYR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 233 GNQTGqeisAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSAFEVPLDtipakfVPVAELDKIAAKARQGHRVPAF 312
Cdd:cd24073 152 GAHGG----AGEIGHTTVDPDGPPCRCGKRGCLEAYASDPAILRQAREAGLR------GEPLTIEDLLAAARAGDPAARA 221
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 517054360 313 AFRQAGLALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQGIEEGL 358
Cdd:cd24073 222 ILRRAGRALGLALANLVNLLDPELIIISGEGVRAGDLLFEPMREAL 267
|
|
| ROK |
pfam00480 |
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
148-408 |
9.38e-14 |
|
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.
Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 71.22 E-value: 9.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 148 ISISSKGLVNSTEPVLVWSPIFGSDQIDFESALRPEWQAKVILDNEtlLVAAALGareEMVKGA--DFRSLAALSLGHSV 225
Cdd:pfam00480 59 VGIGSPGLISPKYGYITNTPNIGWDNFDLVEKLEERFNVPVFFEND--ANAAALA---EAVFGAskDVQNVIYVTVGTGV 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 226 GLGIVRRGN-QTGQEISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSAfEVPLDTIPAKfvpvaeldKIAAKAR 304
Cdd:pfam00480 134 GGGVISNGKlFTGRNGVAGEIGHIQLDPNGPKCGCGNHGCLETIASGRALEKRY-QQKGEDLEGK--------DIIVLAE 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 305 QGHRVPAFAFRQAGLALGNGLSRMLSLTERMPIAITGpgtryydllrqgieeGLGQSHivrmeGMPEiRVVAdeqilVFE 384
Cdd:pfam00480 205 QGDEVAEEAVERLARYLAKAIANLINLFDPQAIVLGG---------------GVSNAD-----GLLE-AIRS-----LVK 258
|
250 260 270
....*....|....*....|....*....|
gi 517054360 385 GHLNRALSVIDEDIVL------SGVQGSAA 408
Cdd:pfam00480 259 KYLNGYLPVPPVIIVAaslgdnAGALGAAA 288
|
|
| ROK_glcA_fam |
TIGR00744 |
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ... |
124-355 |
2.31e-13 |
|
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]
Pssm-ID: 273246 [Multi-domain] Cd Length: 318 Bit Score: 70.31 E-value: 2.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 124 VAAVRAGLLRILDRSKisqEKVLLISISSKGLVNSTEPVLVWSPIFGSDQIDFESALRPEWQAKVILDNETllVAAALGa 203
Cdd:TIGR00744 40 IASAVDSFIQHIAKVG---HEIVAIGIGAPGPVNRQRGTVYFAVNLDWKQEPLKEKVEARVGLPVVVENDA--NAAALG- 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 204 reEMVKGAD--FRSLAALSLGHSVGLGIVRRGN-QTGQEISAPNFGHMLHMANGGL-CRCGTRGCIEAYAGFYAILRSA- 278
Cdd:TIGR00744 114 --EYKKGAGkgARDVICITLGTGLGGGIIINGEiRHGHNGVGAEIGHIRMVPDGRLlCNCGKQGCIETYASATGLVRYAk 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 279 FEVPLDTIPAKFVPVAELDKIAAK-----ARQGHRVPAFAFRQAGLALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQG 353
Cdd:TIGR00744 192 RANAKPERAEVLLALGDGDGISAKhvfvaARQGDPVAVDSYREVARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDP 271
|
..
gi 517054360 354 IE 355
Cdd:TIGR00744 272 IR 273
|
|
| PRK05082 |
PRK05082 |
N-acetylmannosamine kinase; Provisional |
225-278 |
6.21e-05 |
|
N-acetylmannosamine kinase; Provisional
Pssm-ID: 235338 [Multi-domain] Cd Length: 291 Bit Score: 44.52 E-value: 6.21e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 517054360 225 VGLGIVRRGN-QTGQEISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSA 278
Cdd:PRK05082 133 VGGGIVLNGKlLTGPGGLAGHIGHTLADPHGPVCGCGRRGCVEAIASGRAIAAAA 187
|
|
| HTH_MARR |
smart00347 |
helix_turn_helix multiple antibiotic resistance protein; |
13-62 |
7.14e-05 |
|
helix_turn_helix multiple antibiotic resistance protein;
Pssm-ID: 197670 [Multi-domain] Cd Length: 101 Bit Score: 41.43 E-value: 7.14e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 517054360 13 RNSVLVLSVLRRHGALAHTEISDFTGLSSATITAITTELEKAQIIEKSEH 62
Cdd:smart00347 10 PTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPS 59
|
|
| MarR |
pfam01047 |
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ... |
13-62 |
7.98e-05 |
|
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.
Pssm-ID: 426012 [Multi-domain] Cd Length: 59 Bit Score: 40.22 E-value: 7.98e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 517054360 13 RNSVLVLSVLRRHGALAHTEISDFTGLSSATITAITTELEKAQIIEKSEH 62
Cdd:pfam01047 3 LTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRS 52
|
|
| MarR |
COG1846 |
DNA-binding transcriptional regulator, MarR family [Transcription]; |
18-76 |
9.05e-03 |
|
DNA-binding transcriptional regulator, MarR family [Transcription];
Pssm-ID: 441451 [Multi-domain] Cd Length: 142 Bit Score: 36.49 E-value: 9.05e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 517054360 18 VLSVLRRHGALAHTEISDFTGLSSATITAITTELEKAQIIEKSEHqPASGRgrpRVLLR 76
Cdd:COG1846 43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPD-PEDRR---AVLVR 97
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NagC |
COG1940 |
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
78-374 |
1.21e-44 |
|
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];
Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 156.98 E-value: 1.21e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 78 RRDCGYLIVVIISSDAVQYSLVDYAGKLIDRFSEErSHDPAGAGRFVAAVRAGLLRILDRSKISQEKVLLISISSKGLVN 157
Cdd:COG1940 1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIP-TPAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 158 STEPVLVWSPIFGS-DQIDFESALRPEWQAKVILDNETllVAAALGareEMVKGA--DFRSLAALSLGHSVGLGIVRRGN 234
Cdd:COG1940 80 PETGVVLNAPNLPGwRGVPLAELLEERLGLPVFVENDA--NAAALA---EAWFGAgrGADNVVYLTLGTGIGGGIVINGK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 235 -QTGQEISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSAFEvpldtipAKFVPVAELDKIAAKARQGHRVPAFA 313
Cdd:COG1940 155 lLRGANGNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARE-------LGGAEKLTAEELFAAARAGDPLALEV 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517054360 314 FRQAGLALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQGIEEGLGQSHIVRMEGMPEIRV 374
Cdd:COG1940 228 LDEAARYLGIGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVP 288
|
|
| ASKHA_ATPase_ROK_CYANR |
cd24073 |
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ... |
82-358 |
4.17e-36 |
|
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466923 [Multi-domain] Cd Length: 304 Bit Score: 134.22 E-value: 4.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 82 GYLIVVIISSDAVQYSLVDYAGKLIDRFSEE-RSHDPAGAgrfVAAVRAGLLRILDRSKISQEKVLLISISSKGLVNSTE 160
Cdd:cd24073 1 AYVVGVKLTEDRITAVLTDLRGNVLASHTLPlDSGDPEAV---AEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAET 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 161 PVLVWSPIFGSDQIDFESALRPEWQAKVILDNETLLVAAA---LGAreemvkGADFRSLAALSLGHSVGLGIV-----RR 232
Cdd:cd24073 78 GICRWSPLLGWRDVPLAELLEERLGLPVYVENDVNALALAehwFGA------GRGLDNFAVVTIGRGIGCGLVvdgrlYR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 233 GNQTGqeisAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSAFEVPLDtipakfVPVAELDKIAAKARQGHRVPAF 312
Cdd:cd24073 152 GAHGG----AGEIGHTTVDPDGPPCRCGKRGCLEAYASDPAILRQAREAGLR------GEPLTIEDLLAAARAGDPAARA 221
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 517054360 313 AFRQAGLALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQGIEEGL 358
Cdd:cd24073 222 ILRRAGRALGLALANLVNLLDPELIIISGEGVRAGDLLFEPMREAL 267
|
|
| ASKHA_ATPase_ROK_YphH-like |
cd24072 |
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ... |
80-359 |
7.58e-34 |
|
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466922 [Multi-domain] Cd Length: 308 Bit Score: 128.30 E-value: 7.58e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 80 DCGYLIVVIISSdaVQYSLVDYAGKLIDRFsEERSHDPAGAGRFVAAVRAGLLRILDRSKisqEKVLLISISSKGLVNST 159
Cdd:cd24072 1 AWVLGIVVSPNS--LRAQVGNACGELLGEF-EYRVITLETPEALIDEIIDCIDRLLKLWK---DRVKGIALAIQGLVDSH 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 160 EPVLVWSPIFGSDQIDFESALRPEWQAKVILDNETLLVAAALGAREEMVKGADFrslAALSLGHSVGLGIVRRGN-QTGQ 238
Cdd:cd24072 75 KGVSLWSPGAPWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDF---CVINLDYGIGSAIVIDNKlYIGA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 239 EISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSAFEVPLDTIPAKFVPVAELDKIAAKARQGHRVPAFAFRQAG 318
Cdd:cd24072 152 SSGSGEIGHTKVNPDGARCDCGRRGCLETVASNSALKRNARVTLKLGPVSADPEKLTMEQLIEALEEGEPIATQIFDRAA 231
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 517054360 319 LALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQGIEEGLG 359
Cdd:cd24072 232 NAIGRSLANILNLLNPEQVLLYGRGCRAGDLLLPAIRRAIA 272
|
|
| ASKHA_ATPase_ROK_Lmo0178-like |
cd24071 |
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ... |
82-356 |
1.55e-26 |
|
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466921 [Multi-domain] Cd Length: 312 Bit Score: 108.14 E-value: 1.55e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 82 GYLIVVIISSDAVQYSLVDYAGKLIDRfsEERSHDPAGAGRFVAAVRAGLLRILDRSKISQEKVLLISISSKGLVNSTEP 161
Cdd:cd24071 1 GYIIGVKIEEGYLVLALTDLKGKILEK--TRIPFDHETDPEKVIELIAENIKKLIKNKHVEKKLLGIGIAVSGLVDSKKG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 162 VLVWSPIFGSDQIDFESALRPEWQAKVILDNEtllVAAALGAREEMVKGADFRSLAALSLGHSVGLGIVRRGN-QTGQEI 240
Cdd:cd24071 79 IVIRSTILGWENVELKKILKEKFKIPVFIDND---VNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKlYTGNFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 241 SAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSAFEVPLDTIPAKFVPVA--ELDKIAAKARQGHRVPAFAFRQAG 318
Cdd:cd24071 156 GAGEIGHMTIQPDGRKCYCGQKGCLEAYASFEALVNEIKELTESYPLSLLKELEdfEIEKVREAAEEGDSVATELFKKAG 235
|
250 260 270
....*....|....*....|....*....|....*...
gi 517054360 319 LALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQGIEE 356
Cdd:cd24071 236 EYLGIGIKNLINIFNPEAIIIGGEGLEFKDYFLPKIIE 273
|
|
| ASKHA_ATPase_ROK_BsXylR-like |
cd24076 |
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ... |
82-374 |
1.36e-25 |
|
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.
Pssm-ID: 466926 [Multi-domain] Cd Length: 303 Bit Score: 105.34 E-value: 1.36e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 82 GYLIVVIISSDAVQYSLVDYAGKLIDRFSEERSHDPAgAGRFVAAVRAGLLRILDRSKISQEKVLLISISSKGLVNSTEP 161
Cdd:cd24076 1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLPASDD-PDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDSEDG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 162 VLVWSPIFGSDQIDFESALRPEWQAKVILDNETllVAAALGareEMVKGA--DFRSLAALSLGHSVGLGIVRRGN-QTGQ 238
Cdd:cd24076 80 VVLLAPNLGWRDVPLRDLLEEALGVPVFVDNEA--NAAALA---EKRFGAgrGVSDLVYLSAGVGIGAGIILDGElYRGA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 239 EISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSAFEVPLDTIPAKfvpvaeLDKIAAKARQGHRVPAFAFRQAG 318
Cdd:cd24076 155 SGFAGEIGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRLGAGGEPLS------LAELVEAARAGDPAALAALEEVG 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 517054360 319 LALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQGIEEGLGQSHIVRMEGMPEIRV 374
Cdd:cd24076 229 EYLGIGLANLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVV 284
|
|
| ASKHA_NBD_ROK_SgGLK-like |
cd24061 |
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ... |
98-333 |
3.08e-16 |
|
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466911 [Multi-domain] Cd Length: 306 Bit Score: 78.93 E-value: 3.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 98 LVDYAGKLIDRFSEERSHDPAGAGRFVAAVRAGLLRildrskisQEKVLLISISSKGLVNSTEPVLVWSPIFGSDQIDFE 177
Cdd:cd24061 15 VVDEEGEILATERVPTPPTADGIVDAIVEAVEELRE--------GHDVSAVGVAAAGFVDADRATVLFAPNIAWRNEPLK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 178 SALRPEWQAKVILDNETllvAAALGAREEMVKGADFRSLAALSLGHSVGLGIVRRGN-QTGQEISAPNFGHMLHMANGGL 256
Cdd:cd24061 87 DLLEARIGLPVVIENDA---NAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKlLRGAFGIAGEFGHIRVVPDGLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 257 CRCGTRGCIEAYAGFYAILRSAFEVPLDT--IPAKFVPVAELDKIAAK-----ARQGHRVPAFAFRQAGLALGNGLSRML 329
Cdd:cd24061 164 CGCGSRGCWEQYASGRALVRYAKEAANATpeGAAVLLADGSVDGITGKhiseaARAGDPVALDALRELARWLGAGLASLA 243
|
....
gi 517054360 330 SLTE 333
Cdd:cd24061 244 ALLD 247
|
|
| ASKHA_NBD_ROK_ApGLK-like |
cd24063 |
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ... |
83-374 |
3.22e-15 |
|
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466913 [Multi-domain] Cd Length: 308 Bit Score: 75.84 E-value: 3.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 83 YLIVVIISSDAVQYSLVDYAGKLIDRFSEERSHDpaGAGRFVAAVRAGLLRILdRSKISQEKVLLISISSKGLVNSTEPV 162
Cdd:cd24063 1 YYVAVDIGGTWIRAGLVDEDGRILLKIRQPTPKT--GDPGTVSEQVLGLIETL-LSKAGKDSIEGIGVSSAGPLDLRKGT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 163 LVWSPIFGSDQIDFESALRPEWQAKVILDNETllVAAALGareEMVKGA--DFRSLAALSLGHSVGLGIVRRGNQ-TGQE 239
Cdd:cd24063 78 IVNSPNIKGKEIPLVEPLKEEFNIPVALLNDA--VAAALG---EHLFGAgrGTSNLVYITISTGIGGGVIVDGRLlLGKN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 240 ISAPNFGHM-LHMANGGLCRCGTRGCIEAYAGFYAILRSAFEV--PLDTIPAKFVPVAELDKIAAK-----ARQGHRVPA 311
Cdd:cd24063 153 GNAAEVGHLvVDTESGLKCGCGGYGHWEAFASGRGIPRFAREWaeGFSSRTSLKLRNPGGEGITAKevfsaARKGDPLAL 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517054360 312 FAFRQAGLALGNGLSRMLSLTERMPIAITGPGTRYY-DLLRQGIEEGLGQSHIVRmegMPEIRV 374
Cdd:cd24063 233 KIIEKLARYNGRGIANVINAYDPELIVIGGSVFNNNkDILDPLIEYLEKNPAISK---GPEIVL 293
|
|
| ASKHA_NBD_ROK_TmGLK-like |
cd24064 |
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ... |
140-356 |
1.15e-14 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466914 [Multi-domain] Cd Length: 301 Bit Score: 74.07 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 140 ISQEKVLLISISSKGLVNSTEPVLVWSPIFgSDQIDFE--SALRPEWQAKVILDNETllVAAALGAREeMVKGADFRSLA 217
Cdd:cd24064 51 IEEMELLGIGIGSPGSIDRENGIVRFSPNF-PDWRNFPlvPLIEERTGIKVFLENDA--NAFALGEWW-FGNAKGSNHII 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 218 ALSLGHSVGLGIVRRGNQ-TGQEISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSAFEVpLDTIPAKFvpVAEL 296
Cdd:cd24064 127 GLTLGTGVGSGVICHGQLlTGYDGIAAELGHVIVEPNGPICGCGNRGCVEAFASATAIIRYARES-RKRYPDSL--AGES 203
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517054360 297 DKIAAK-----ARQGHRVPAFAFRQAGLALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQGIEE 356
Cdd:cd24064 204 EKINAKhvfdaARKNDPLATMVFRRVVDALAIAIGGFVHIFNPEIIIIGGGISRAGSFLLDPIRE 268
|
|
| ROK |
pfam00480 |
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
148-408 |
9.38e-14 |
|
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.
Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 71.22 E-value: 9.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 148 ISISSKGLVNSTEPVLVWSPIFGSDQIDFESALRPEWQAKVILDNEtlLVAAALGareEMVKGA--DFRSLAALSLGHSV 225
Cdd:pfam00480 59 VGIGSPGLISPKYGYITNTPNIGWDNFDLVEKLEERFNVPVFFEND--ANAAALA---EAVFGAskDVQNVIYVTVGTGV 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 226 GLGIVRRGN-QTGQEISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSAfEVPLDTIPAKfvpvaeldKIAAKAR 304
Cdd:pfam00480 134 GGGVISNGKlFTGRNGVAGEIGHIQLDPNGPKCGCGNHGCLETIASGRALEKRY-QQKGEDLEGK--------DIIVLAE 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 305 QGHRVPAFAFRQAGLALGNGLSRMLSLTERMPIAITGpgtryydllrqgieeGLGQSHivrmeGMPEiRVVAdeqilVFE 384
Cdd:pfam00480 205 QGDEVAEEAVERLARYLAKAIANLINLFDPQAIVLGG---------------GVSNAD-----GLLE-AIRS-----LVK 258
|
250 260 270
....*....|....*....|....*....|
gi 517054360 385 GHLNRALSVIDEDIVL------SGVQGSAA 408
Cdd:pfam00480 259 KYLNGYLPVPPVIIVAaslgdnAGALGAAA 288
|
|
| ROK_glcA_fam |
TIGR00744 |
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ... |
124-355 |
2.31e-13 |
|
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]
Pssm-ID: 273246 [Multi-domain] Cd Length: 318 Bit Score: 70.31 E-value: 2.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 124 VAAVRAGLLRILDRSKisqEKVLLISISSKGLVNSTEPVLVWSPIFGSDQIDFESALRPEWQAKVILDNETllVAAALGa 203
Cdd:TIGR00744 40 IASAVDSFIQHIAKVG---HEIVAIGIGAPGPVNRQRGTVYFAVNLDWKQEPLKEKVEARVGLPVVVENDA--NAAALG- 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 204 reEMVKGAD--FRSLAALSLGHSVGLGIVRRGN-QTGQEISAPNFGHMLHMANGGL-CRCGTRGCIEAYAGFYAILRSA- 278
Cdd:TIGR00744 114 --EYKKGAGkgARDVICITLGTGLGGGIIINGEiRHGHNGVGAEIGHIRMVPDGRLlCNCGKQGCIETYASATGLVRYAk 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 279 FEVPLDTIPAKFVPVAELDKIAAK-----ARQGHRVPAFAFRQAGLALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQG 353
Cdd:TIGR00744 192 RANAKPERAEVLLALGDGDGISAKhvfvaARQGDPVAVDSYREVARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDP 271
|
..
gi 517054360 354 IE 355
Cdd:TIGR00744 272 IR 273
|
|
| ASKHA_ATPase_ROK_SaXylR-like |
cd24077 |
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ... |
148-276 |
7.30e-12 |
|
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466927 [Multi-domain] Cd Length: 295 Bit Score: 65.64 E-value: 7.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 148 ISISSKGLVNSTEpvLVWSPIFGSDQIDFESALRPEWQAKVILDNETLLvaAALGareEMVKGADFRSLAALSLGHSVGL 227
Cdd:cd24077 65 IGIGIHGIVDENE--IIFTPYYDLEDIDLKEKLEEKFNVPVYLENEANL--SALA---ERTFSEDYDNLISISIHSGIGA 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 517054360 228 GIVRRGN-QTGQEISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILR 276
Cdd:cd24077 138 GIIINNQlYRGYNGFAGEIGHMIIVPNGKPCPCGNKGCLEQYASEKALLK 187
|
|
| ASKHA_NBD_ROK_TM1224-like |
cd24059 |
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ... |
83-278 |
7.45e-11 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466909 [Multi-domain] Cd Length: 305 Bit Score: 62.60 E-value: 7.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 83 YLIVVIISSDAVQYSLVDYAGKLIDRFSEERSHDPAGAGrFVAAVRAGLLRILDRSKIsQEKVLLISISSKGLVNSTEPV 162
Cdd:cd24059 2 YVIGVEIGRDLLSAVLCDLSGNILAREKYPLDEKENPEE-VLEKLYELIDRLLEKENI-KSKILGIGIGAPGPLDVEKGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 163 LVWSPIF-GSDQIDFESALRPEWQAKVILDNETllVAAALGarEEMV-KGADFRSLAALSLGHSVGLGIVRRG----NQT 236
Cdd:cd24059 80 ILNPPNFpGWENIPLVELLEEKFGIPVYLDNDA--NAAALA--EKWYgKGKNYDNFIYILADEGIGAGIIINGklyrGVD 155
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 517054360 237 GQeisAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSA 278
Cdd:cd24059 156 GY---AGEIGHTSIDINGPRCSCGNRGCLELYASIPAIEKKA 194
|
|
| ASKHA_NBD_ROK_FnNanK-like |
cd24068 |
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ... |
93-280 |
4.45e-10 |
|
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466918 [Multi-domain] Cd Length: 294 Bit Score: 60.26 E-value: 4.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 93 AVQYSLVDYAGKLIDRFSeerSHDPAGAGRfvAAVRAGLLRILDRSKiSQEKVLLISISSKGLVNS-TEPVLVWSPIF-G 170
Cdd:cd24068 11 KIKYGLVDADGEILEKDS---VPTPASKGG--DAILERLLEIIAELK-EKYDIEGIGISSAGQVDPkTGEVIYATDNLpG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 171 SDQIDFESALRPEWQAKVILDNEtllV-AAALGareEMVKGA--DFRSLAALSLGHSVGLGIVRRGN-QTGQEISAPNFG 246
Cdd:cd24068 85 WTGTNLKEELEERFGLPVAVEND---VnCAALA---EKWLGAakGLDDFLCLTLGTGIGGAIILDGRlYRGANGSAGELG 158
|
170 180 190
....*....|....*....|....*....|....
gi 517054360 247 HMLHMANGGLCRCGTRGCIEAYAGFYAILRSAFE 280
Cdd:cd24068 159 HMVVDPGGRPCCCGGKGCLEQYASGTALVRRVAE 192
|
|
| ASKHA_ATPase_ROK |
cd23763 |
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ... |
98-248 |
1.88e-09 |
|
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.
Pssm-ID: 466849 [Multi-domain] Cd Length: 239 Bit Score: 57.86 E-value: 1.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 98 LVDYAGKLIDRFSEErSHDPAGAGRFVAAVRAGLLRILDRSKIsQEKVLLISISSKGLVNSTEPVLVWSP-IFGSDQIDF 176
Cdd:cd23763 14 LVDLDGEILARERVP-TPAEEGPEAVLDRIAELIEELLAEAGV-RERILGIGIGVPGPVDPETGIVLFAPnLPWWKNVPL 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517054360 177 ESALRPEWQAKVILDNETllVAAALGareEMVKGA--DFRSLAALSLGHSVGLGIV-----RRGNqTGqeiSAPNFGHM 248
Cdd:cd23763 92 RELLEERLGLPVVVENDA--NAAALG---EAWFGAgrGVRNFVYITLGTGIGGGIIidgklYRGA-NG---AAGEIGHI 161
|
|
| ASKHA_NBD_ROK_GNE |
cd24060 |
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ... |
144-329 |
1.11e-08 |
|
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.
Pssm-ID: 466910 [Multi-domain] Cd Length: 305 Bit Score: 56.27 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 144 KVLLISISSKGLVNSTEPVLVWSP--IFGSDQIDFESALRPEWQAKVILDNETllVAAALGAREeMVKGADFRSLAALSL 221
Cdd:cd24060 59 RILGVGISTGGRVNPREGIVLHSTklIQEWSSVDLRTPISDALHLPVWVDNDG--NCAALAERK-FGHGKGVENFVTVIT 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 222 GHSVGLGIVRRGNQT-GQEISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSA---FEVPLDTIPAKFVPVAEld 297
Cdd:cd24060 136 GTGIGGGIILNHELIhGSSFCAAELGHIVVSLDGPDCMCGSHGCVEAYASGMALQREAkklHDEDLLLVEGMSVTNDE-- 213
|
170 180 190
....*....|....*....|....*....|....*..
gi 517054360 298 KIAAK-----ARQGHRVPAFAFRQAGLALGNGLSRML 329
Cdd:cd24060 214 EVTAKhliqaAKLGNAKAQKILRTAGTALGLGIVNIL 250
|
|
| ASKHA_NBD_ROK_BsGLK-like |
cd24062 |
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ... |
93-356 |
1.23e-08 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466912 [Multi-domain] Cd Length: 311 Bit Score: 56.14 E-value: 1.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 93 AVQYSLVDYAGKLIDRFSEERSHDPAGAGrFVAAVRAGLLRILDRSKISQEKVLLISISSKGLVNSTEPVLVWSPIFGSD 172
Cdd:cd24062 11 TIKMAFLTQEGEIVQKWEIPTNKLEGGEN-IITDIAESIQQLLEELGYSKEDLIGIGVGVPGPVDVETGTVEVAVNLGWK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 173 QIDFESALRPEWQAKVILDNETllVAAALGareEMVKGA--DFRSLAALSLGHSVGLGIVRRG------NQTGQEIsapn 244
Cdd:cd24062 90 NFPLKDKLEALTGIPVVIDNDA--NAAALG---EMWKGAgqGAKDLVFITLGTGVGGGVIANGkivhgaNGAAGEI---- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 245 fGHMLHMANGGL-CRCGTRGCIEAYAGFYAILRSAFE-VPLDTIPAKFVPVAELDKIAAK-----ARQGHRVPAFAFRQA 317
Cdd:cd24062 161 -GHITVNPEGGApCNCGKTGCLETVASATGIVRIAREeLEEGKGSSALRILALGGELTAKdvfeaAKAGDELALAVVDTV 239
|
250 260 270
....*....|....*....|....*....|....*....
gi 517054360 318 GLALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQGIEE 356
Cdd:cd24062 240 ARYLGLALANLANTLNPEKIVIGGGVSAAGEFLLSPVKE 278
|
|
| ASKHA_NBD_ROK_EcNanK-like |
cd24069 |
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ... |
103-354 |
1.16e-06 |
|
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466919 [Multi-domain] Cd Length: 283 Bit Score: 49.59 E-value: 1.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 103 GKLIDR--FSEERSHDPAGAGRFVAAVRAGLLRILDRskisqekvllISISSKGLVNSTepvlVWSP-----IFGSDQID 175
Cdd:cd24069 18 GQIIDRrqIPTPRSGTPEALADALASLLADYQGQFDR----------VAVASTGIIRDG----VLTAlnpknLGGLSGFP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 176 FESALRPEWQAKVILDNETllVAAALGareEMVKGA--DFRSLAALSLGHSVGLGIVRRGN-QTGQEISAPNFGHMLHMA 252
Cdd:cd24069 84 LADALQQLLGVPVVLLNDA--QAAAWG---EYQAGDgeGVGNLVFITVSTGVGGGLVLNGQlLTGPNGLAGHIGHTLADP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 253 NGGLCRCGTRGCIEAYAGFYAILRSAFEVPLDTIPAKfvpvaeldKIAAKARQGHRVPAFAFRQAGLALGNGLSRMLSLT 332
Cdd:cd24069 159 PGPVCGCGRRGCVEAIASGTAIAAAASEILGEPVDAK--------DVFERARSGDEEAARLIDRAARALADLIADLKATL 230
|
250 260
....*....|....*....|....*..
gi 517054360 333 ERMPIAITG-----PGtrYYDLLRQGI 354
Cdd:cd24069 231 DLDCVVIGGsvglaEG--FLERVEQYL 255
|
|
| ASKHA_NBD_ROK_TtHK-like |
cd24065 |
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ... |
117-325 |
2.11e-05 |
|
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466915 [Multi-domain] Cd Length: 289 Bit Score: 45.78 E-value: 2.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 117 PAGAGRFVAAVRAGLLRILDRSkisQEKVLLISISSKGLVNSTEPVLVWSP-IFGSDQIDFESALRPEWQAKVILDNETl 195
Cdd:cd24065 31 PREGGEAVLDALARAVEALQAE---APGVEAVGLGVPGPLDFRRGRVRFAPnIPGLTDFPIRRGLAERLGLPVVLENDA- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 196 lVAAALgareemvkgADFRSLAALSLGHSV--------GLGIVRRGN----QTGQeisAPNFGHMLHMANGGLCRCGTRG 263
Cdd:cd24065 107 -NAAAL---------AEHHYGAARGTESSVyvtistgiGGGLVLGGRvlrgRHGQ---AGEIGHTTVLPGGPMCGCGLVG 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517054360 264 CIEAYAGFYAILRSA---FEVPLDTiPAKFvpvaeldkiaAKARQGHRVPAFAFRQAGLALGNGL 325
Cdd:cd24065 174 CLEALASGRALARDAsfaYGRPMST-AELF----------ELAQQGEPKALRIVEQAAAHLGIGL 227
|
|
| ASKHA_NBD_ROK_AlsK |
cd24070 |
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ... |
96-299 |
2.22e-05 |
|
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466920 [Multi-domain] Cd Length: 293 Bit Score: 46.00 E-value: 2.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 96 YSLVDYAGKLIDrFSEERSHDPAGAGRFVAAVRAGLLRILDRSKIsqeKVLLISISSKGLVNSTEPVLVWSP-IFGSDQI 174
Cdd:cd24070 15 IGLVDEDGKLLD-FEKVPSKDLLRAGDPVEVLADLIREYIEEAGL---KPAAIVIGVPGTVDKDRRTVISTPnIPGLDGV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 175 DFESALRPEWQAKVILDNEtllvaAALGAREEMVKGAdfRSLAALSLGHSVGLGIvrrGNQ--------TGQEISAPNFG 246
Cdd:cd24070 91 NLADILENKLGIPVILERD-----VNLLLLYDMRAGN--LDDEGVVLGFYIGTGI---GNAilingkplRGKNGVAGELG 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 517054360 247 HMLHMANGGLCRCGTRGCIEAYA-GFY--AILRSAF-EVPLDTIPAKFVPVAELDKI 299
Cdd:cd24070 161 HIPVYGNGKPCGCGNTGCLETYAsGRAleEIAEEHYpDTPILDIFVDHGDEPELDEF 217
|
|
| PRK05082 |
PRK05082 |
N-acetylmannosamine kinase; Provisional |
225-278 |
6.21e-05 |
|
N-acetylmannosamine kinase; Provisional
Pssm-ID: 235338 [Multi-domain] Cd Length: 291 Bit Score: 44.52 E-value: 6.21e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 517054360 225 VGLGIVRRGN-QTGQEISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSA 278
Cdd:PRK05082 133 VGGGIVLNGKlLTGPGGLAGHIGHTLADPHGPVCGCGRRGCVEAIASGRAIAAAA 187
|
|
| ASKHA_NBD_ROK_EcFRK-like |
cd24066 |
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ... |
199-331 |
7.14e-05 |
|
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466916 [Multi-domain] Cd Length: 294 Bit Score: 44.50 E-value: 7.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 199 AALGAreemvkGADFRSLAALSLGHSVGLGIVRRGN-QTGQEISAPNFGHM------LHMANGGLCRCGTRGCIEAYAGF 271
Cdd:cd24066 113 ATDGA------GAGAGVVFGVILGTGVGGGIVVNGRvLTGANGIAGEWGHNplpwpdEDELPGPPCYCGKRGCVETFLSG 186
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 272 YAILRSAFEVPLDTIPAKfvpvaeldKIAAKARQGHRVPAFAFRQAGLALGNGLSRMLSL 331
Cdd:cd24066 187 PALERDYARLTGKTLSAE--------EIVALARAGDAAAVATLDRFLDRLGRALANVINI 238
|
|
| HTH_MARR |
smart00347 |
helix_turn_helix multiple antibiotic resistance protein; |
13-62 |
7.14e-05 |
|
helix_turn_helix multiple antibiotic resistance protein;
Pssm-ID: 197670 [Multi-domain] Cd Length: 101 Bit Score: 41.43 E-value: 7.14e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 517054360 13 RNSVLVLSVLRRHGALAHTEISDFTGLSSATITAITTELEKAQIIEKSEH 62
Cdd:smart00347 10 PTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPS 59
|
|
| MarR |
pfam01047 |
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ... |
13-62 |
7.98e-05 |
|
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.
Pssm-ID: 426012 [Multi-domain] Cd Length: 59 Bit Score: 40.22 E-value: 7.98e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 517054360 13 RNSVLVLSVLRRHGALAHTEISDFTGLSSATITAITTELEKAQIIEKSEH 62
Cdd:pfam01047 3 LTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRS 52
|
|
| ASKHA_ATPase_ROK_NagC |
cd24075 |
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ... |
142-378 |
3.20e-04 |
|
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466925 [Multi-domain] Cd Length: 315 Bit Score: 42.35 E-value: 3.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 142 QEKVLLISISSKGLVNSTEPVLVWSPIFGSDQIDFESALRPEWQAKVILDNETLLVAAAlgareEMVKGA--DFRSLAAL 219
Cdd:cd24075 59 TQRLIAISITLPGLINPKTGVVHYMPHIQVKSWPIVEELEQRFNVPCFIGNDIRSLALA-----EHYFGAskDCKDSILV 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 220 SLGHSVGLGIVRRGNQ-TGQEISAPNFGHMLHMANGGLCRCGTRGCIEAYAGFYAILRSAFEVpLDTIPAKFVPVAELD- 297
Cdd:cd24075 134 RIHHGIGAGIIIDGKLfLGQNGNAGEIGHIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKL-LKQGYASQLTLQDCTi 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 298 -KIAAKARQGHRVPAFAFRQAGLALGNGLSRMLSLTERMPIAITGPGTRYYDLLRQGIEEGLGQSHIVRMEgmPEIRVVA 376
Cdd:cd24075 213 kDICQAALNGDQLAQDVIKRAGRYLGKVIAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFR--QELKIVA 290
|
..
gi 517054360 377 DE 378
Cdd:cd24075 291 SQ 292
|
|
| ASKHA_NBD_ROK-like |
cd24152 |
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ... |
93-250 |
2.87e-03 |
|
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466988 [Multi-domain] Cd Length: 286 Bit Score: 39.47 E-value: 2.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 93 AVQYSLVDYAGKLIDRFSEERSHDPAGAgrFVAAVRagllRILDRSKisqEKVLLISISSKGLVNSTEPVlvwspIFGS- 171
Cdd:cd24152 11 FIKYALVDENGNIIKKGKIPTPKDSLEE--FLDYIK----KIIKRYD---EEIDGIAISAPGVIDPETGI-----IYGGg 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 172 -----DQIDFESALRPEWQAKVILDNETLlvAAALGareEMVKGA--DFRSLAALSLGHSVGLGI-----VRRGNQtgqe 239
Cdd:cd24152 77 alpylKGFNLKEELEERCNLPVSIENDAK--CAALA---ELWLGSlkGIKNGAVIVLGTGIGGAIiidgkLYRGSH---- 147
|
170
....*....|.
gi 517054360 240 ISAPNFGHMLH 250
Cdd:cd24152 148 FFAGEFSYLLT 158
|
|
| HTH_24 |
pfam13412 |
Winged helix-turn-helix DNA-binding; |
18-57 |
4.62e-03 |
|
Winged helix-turn-helix DNA-binding;
Pssm-ID: 404317 [Multi-domain] Cd Length: 45 Bit Score: 34.72 E-value: 4.62e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 517054360 18 VLSVLRRHGALAHTEISDFTGLSSATITAITTELEKAQII 57
Cdd:pfam13412 6 ILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
|
|
| MarR |
COG1846 |
DNA-binding transcriptional regulator, MarR family [Transcription]; |
18-76 |
9.05e-03 |
|
DNA-binding transcriptional regulator, MarR family [Transcription];
Pssm-ID: 441451 [Multi-domain] Cd Length: 142 Bit Score: 36.49 E-value: 9.05e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 517054360 18 VLSVLRRHGALAHTEISDFTGLSSATITAITTELEKAQIIEKSEHqPASGRgrpRVLLR 76
Cdd:COG1846 43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPD-PEDRR---AVLVR 97
|
|
| ASKHA_ATPase_ROK_Mlc |
cd24074 |
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ... |
143-354 |
9.47e-03 |
|
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466924 [Multi-domain] Cd Length: 322 Bit Score: 37.68 E-value: 9.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 143 EKVLLISISSKGLVNSTEPVLVWSPIFGSDQIdfesALRPEWQAKVIL------DNETLLVAAAL-GAreemVKGADfrS 215
Cdd:cd24074 61 ERLTAIAITLPGIIDPESGIVHRLPFYDIKNL----PLGEALEQHTGLpvyvqhDISAWTLAERFfGA----AKGAK--N 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517054360 216 LAALSLGHSVGLGIVRRGNQTGQEISAPN-FGHMlHMANGGL-CRCGTRGCIEAYAGFYAILRSAFEVPLDTIPAKF-VP 292
Cdd:cd24074 131 IIQIVIDDDIGAGVITDGQLLHAGSSRLGeLGHT-QIDPYGKrCYCGNHGCLETVASIPAILEQANQLLEQSPDSMLhGQ 209
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517054360 293 VAELDKIAAKARQGHRVPAFAFRQAGLALGNGLSRMLSLTERMPIAITGPGTR----YYDLLRQGI 354
Cdd:cd24074 210 PISIESLCQAALAGDPLAQDIIIQVGRHLGRILAILVNLFNPEKILIGSPLNNaaeiLFPALSQSI 275
|
|
| |
