|
Name |
Accession |
Description |
Interval |
E-value |
| TTC |
TIGR02089 |
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ... |
3-356 |
0e+00 |
|
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]
Pssm-ID: 273963 Cd Length: 352 Bit Score: 657.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 3 KKQYRIAVIPGDGIGKEVMPEGLRVLEAAAKKHG-VSLQFDHFDFSsWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWP 81
Cdd:TIGR02089 1 MKQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPWS-CDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 82 AKIPDHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPSPLAGRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREFVTQQT 161
Cdd:TIGR02089 80 ALVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVTSPLRNCGPGDFDFVVVRENSEGEYSGVGGRIHRGTDEEVATQNA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 162 VMTRTGVDRILKFAFELAQSRpKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVV 241
Cdd:TIGR02089 160 IFTRKGVERIMRFAFELAQKR-RKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 242 VGSNLFGDILSDLGPACTGTIGIAPSGNINPEGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSI 321
Cdd:TIGR02089 239 VASNLFGDILSDLGAALMGSLGVAPSANINPEGKFPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKI 318
|
330 340 350
....*....|....*....|....*....|....*
gi 517126793 322 VEAIERTLAERtLRTKDLGGNADTTACGKAVADMV 356
Cdd:TIGR02089 319 MDAIERVTAAG-ILTPDVGGKATTSEVTEAVCNAL 352
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
6-354 |
0e+00 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 566.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 6 YRIAVIPGDGIGKEVMPEGLRVLEAAAKKHGVSLQFDHFDFSsWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWPaKIP 85
Cdd:COG0473 2 YKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIG-GAAYDKTGTPLPDETLEALRKADAILLGAVGGP-KWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 86 DHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPSPLAGRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREFVTQQTVMTR 165
Cdd:COG0473 80 DGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDTRVYTR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 166 TGVDRILKFAFELAQSRpKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVVVGSN 245
Cdd:COG0473 160 KGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 246 LFGDILSDLGPACTGTIGIAPSGNINPEGdfPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSIVEAI 325
Cdd:COG0473 239 LFGDILSDLAAGLTGSLGLAPSANIGDEG--KALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAV 316
|
330 340
....*....|....*....|....*....
gi 517126793 326 ERTLAERTlRTKDLGGNADTTACGKAVAD 354
Cdd:COG0473 317 EKVLAEGV-RTPDLGGKAGTSEMGDAIIA 344
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
4-352 |
4.89e-178 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 497.71 E-value: 4.89e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 4 KQYRIAVIPGDGIGKEVMPEGLRVLEAAAKKHGvSLQFDHFDFS-SWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWPA 82
Cdd:PRK08194 2 KQFKIAVIPGDGVGKEVVPAAVRVLKAVAEVHG-GLKFEFTEFPwSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 83 KIPDHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPSPLAGrkPGDIDFWVVRENTEGEYSSVGGRMFPDTDrEFVTQQTV 162
Cdd:PRK08194 81 LVPDHISLWGLLIKIRREFEQVINIRPAKQLRGIKSPLAN--PKDFDLLVVRENSEGEYSEVGGRIHRGED-EIAIQNAV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 163 MTRTGVDRILKFAFELAQSRpKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVVV 242
Cdd:PRK08194 158 FTRKGTERAMRYAFELAAKR-RKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEFDVIV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 243 GSNLFGDILSDLGPACTGTIGIAPSGNINPEGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSIV 322
Cdd:PRK08194 237 ASNLFGDILTDIGAAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLL 316
|
330 340 350
....*....|....*....|....*....|
gi 517126793 323 EAIERTLaERTLRTKDLGGNADTTACGKAV 352
Cdd:PRK08194 317 DVIEDVT-EDGIKTPDIGGRATTDEVTDEI 345
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
7-352 |
8.11e-105 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 311.54 E-value: 8.11e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 7 RIAVIPGDGIGKEVMPEGLRVLEAAAKKHGVSLQFDHFDFSSwDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWPAKIPD 86
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGG-AAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 87 HVSLWGSLIKFRREFDQYVNLRPVRLMP--GVPSPLAgRKPGDIDFWVVRENTEGEYSSVGgRMFPDTDREFVTQQTVMT 164
Cdd:pfam00180 80 GVRPENGLLALRKELGLFANLRPAKVFPplGDASPLK-NEVEGVDIVIVRELTGGIYFGIE-KGIKGSGNEVAVDTKLYS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 165 RTGVDRILKFAFELAQSRPKKHLTSATKSNgISITMPYWDERVEAMAK-KFPGVKWDKYHIDILTANFVLHPDWFDVVVG 243
Cdd:pfam00180 158 RDEIERIARVAFELARKRGRKKVTSVDKAN-VLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVIVT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 244 SNLFGDILSDLGPACTGTIGIAPSGNINPEGdfPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEH-LGEKEAGQSIV 322
Cdd:pfam00180 237 PNLFGDILSDEASMLTGSLGLLPSASLGANG--FGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIE 314
|
330 340 350
....*....|....*....|....*....|...
gi 517126793 323 EAIERTLAERTlRTKDLGGNAD---TTACGKAV 352
Cdd:pfam00180 315 AAVLKVLESGI-RTGDLAGSATyvsTSEFGEAV 346
|
|
| AksF2_Meth |
NF040626 |
homoisocitrate dehydrogenase; |
6-352 |
7.87e-96 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468598 Cd Length: 332 Bit Score: 288.17 E-value: 7.87e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 6 YRIAVIPGDGIGKEVMPEGLRVLEAaakkhgVSLQFDHFD-FSSWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVgwpAKI 84
Cdd:NF040626 2 YKITVIPGDGIGKEVMEAALYVLDA------LDLNFDFIEaEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV---TST 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 85 PDHVSlwgSLIKFRREFDQYVNLRPVRLMPGVPSPLAgrkpgDIDFWVVRENTEGEYSSVGGRmfpdTDREFVTQQTVMT 164
Cdd:NF040626 73 PGQKS---PIITLRKELDLYANLRPIKSYEGINCLFK-----DLDFLIVRENTEGLYSGLEEE----YTEEKAIAERVIT 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 165 RTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVVVGS 244
Cdd:NF040626 141 RKASERICKFAFEYAIKLGRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTT 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 245 NLFGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSIVEA 324
Cdd:NF040626 221 NLFGDILSDEAAGLVGGLGLAPSANI---GDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENA 297
|
330 340
....*....|....*....|....*...
gi 517126793 325 IERTLAERTLRTKDLGGNADTTACGKAV 352
Cdd:NF040626 298 LEKVLREGKVVTPDLGGNAKTMEMANEI 325
|
|
| AksF_Meth |
NF040619 |
homoisocitrate dehydrogenase; |
6-352 |
3.95e-82 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468591 Cd Length: 332 Bit Score: 253.14 E-value: 3.95e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 6 YRIAVIPGDGIGKEVMPEGLRVLEaaakkhgvslQFDHFDF----SSWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWP 81
Cdd:NF040619 2 PKICVIEGDGIGKEVIPETVRVLK----------ELGDFEFikgeAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 82 AKIPDHVSLWGS-LIKFRREFDQYVNLRPVRLMPgvpsplAGRKPGDIDFWVVRENTEGEYSsvgGRMFPDTDREFVTQQ 160
Cdd:NF040619 72 KPTELKNKNYKSpILTLRKELDLYANVRPINNFG------DGQDVKNIDFVIIRENTEGLYV---GREYYDEENEIAIAE 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 161 TVMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKKF--PGVKWDKYHIDILTANFVLHPDWF 238
Cdd:NF040619 143 RIISKKGSERIIKFAFEYAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEMF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 239 DVVVGSNLFGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAG 318
Cdd:NF040619 223 DVIVTTNLFGDILSDEASGLIGGLGLAPSANI---GDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKG 299
|
330 340 350
....*....|....*....|....*....|....
gi 517126793 319 QSIVEAIERTLAERTLrTKDLGGNADTTACGKAV 352
Cdd:NF040619 300 DLIREAVKKCLENGKV-TPDLGGNLKTKEVTDKI 332
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TTC |
TIGR02089 |
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ... |
3-356 |
0e+00 |
|
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]
Pssm-ID: 273963 Cd Length: 352 Bit Score: 657.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 3 KKQYRIAVIPGDGIGKEVMPEGLRVLEAAAKKHG-VSLQFDHFDFSsWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWP 81
Cdd:TIGR02089 1 MKQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPWS-CDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 82 AKIPDHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPSPLAGRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREFVTQQT 161
Cdd:TIGR02089 80 ALVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVTSPLRNCGPGDFDFVVVRENSEGEYSGVGGRIHRGTDEEVATQNA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 162 VMTRTGVDRILKFAFELAQSRpKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVV 241
Cdd:TIGR02089 160 IFTRKGVERIMRFAFELAQKR-RKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 242 VGSNLFGDILSDLGPACTGTIGIAPSGNINPEGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSI 321
Cdd:TIGR02089 239 VASNLFGDILSDLGAALMGSLGVAPSANINPEGKFPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKI 318
|
330 340 350
....*....|....*....|....*....|....*
gi 517126793 322 VEAIERTLAERtLRTKDLGGNADTTACGKAVADMV 356
Cdd:TIGR02089 319 MDAIERVTAAG-ILTPDVGGKATTSEVTEAVCNAL 352
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
6-354 |
0e+00 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 566.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 6 YRIAVIPGDGIGKEVMPEGLRVLEAAAKKHGVSLQFDHFDFSsWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWPaKIP 85
Cdd:COG0473 2 YKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIG-GAAYDKTGTPLPDETLEALRKADAILLGAVGGP-KWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 86 DHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPSPLAGRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREFVTQQTVMTR 165
Cdd:COG0473 80 DGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDTRVYTR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 166 TGVDRILKFAFELAQSRpKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVVVGSN 245
Cdd:COG0473 160 KGIERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 246 LFGDILSDLGPACTGTIGIAPSGNINPEGdfPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSIVEAI 325
Cdd:COG0473 239 LFGDILSDLAAGLTGSLGLAPSANIGDEG--KALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAV 316
|
330 340
....*....|....*....|....*....
gi 517126793 326 ERTLAERTlRTKDLGGNADTTACGKAVAD 354
Cdd:COG0473 317 EKVLAEGV-RTPDLGGKAGTSEMGDAIIA 344
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
4-352 |
4.89e-178 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 497.71 E-value: 4.89e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 4 KQYRIAVIPGDGIGKEVMPEGLRVLEAAAKKHGvSLQFDHFDFS-SWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWPA 82
Cdd:PRK08194 2 KQFKIAVIPGDGVGKEVVPAAVRVLKAVAEVHG-GLKFEFTEFPwSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 83 KIPDHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPSPLAGrkPGDIDFWVVRENTEGEYSSVGGRMFPDTDrEFVTQQTV 162
Cdd:PRK08194 81 LVPDHISLWGLLIKIRREFEQVINIRPAKQLRGIKSPLAN--PKDFDLLVVRENSEGEYSEVGGRIHRGED-EIAIQNAV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 163 MTRTGVDRILKFAFELAQSRpKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVVV 242
Cdd:PRK08194 158 FTRKGTERAMRYAFELAAKR-RKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEFDVIV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 243 GSNLFGDILSDLGPACTGTIGIAPSGNINPEGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSIV 322
Cdd:PRK08194 237 ASNLFGDILTDIGAAIMGSIGIAPAANINVNGKYPSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHLL 316
|
330 340 350
....*....|....*....|....*....|
gi 517126793 323 EAIERTLaERTLRTKDLGGNADTTACGKAV 352
Cdd:PRK08194 317 DVIEDVT-EDGIKTPDIGGRATTDEVTDEI 345
|
|
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
2-356 |
7.52e-139 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 398.15 E-value: 7.52e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 2 SKKQYRIAVIPGDGIGKEVMPEGLRVLEAAAKKhGVSLQFDHFDFSSwDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWP 81
Cdd:PRK03437 1 MAKTMKLAVIPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGA-RRYLRTGETLPDSVLAELRQHDAILLGAIGDP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 82 AkIPDHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPSPLAGrkPGDIDFWVVRENTEGEYSSVGGRMFPDTDREFVTQQT 161
Cdd:PRK03437 79 S-VPSGVLERGLLLKLRFALDHYVNLRPSKLYPGVTSPLAG--PGDIDFVVVREGTEGPYTGNGGALRVGTPHEVATEVS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 162 VMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVV 241
Cdd:PRK03437 156 VNTAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 242 VGSNLFGDILSDLGPACTGTIGIAPSGNINPEGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSI 321
Cdd:PRK03437 236 VTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTNPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARI 315
|
330 340 350
....*....|....*....|....*....|....*
gi 517126793 322 VEAIERTLAERtlrtkdLGGNADTTACGKAVADMV 356
Cdd:PRK03437 316 EAAVEADLAER------GKMGRSTAEVGDRIAARL 344
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
4-354 |
1.56e-123 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 359.41 E-value: 1.56e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 4 KQYRIAVIPGDGIGKEVMPEGLRVLEAAAKKHGVSLQFDHFDFSSwDYYEKHGQMMPDDWKEKIGKHDAIYFGAVG---W 80
Cdd:PRK00772 1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGG-AAIDAHGVPLPEETLEACRAADAVLLGAVGgpkW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 81 PAKIPDHVSLWGsLIKFRREFDQYVNLRPVRLMPGV--PSPLagrKP---GDIDFWVVRENTEGEYSSVGGRMFPDTDRE 155
Cdd:PRK00772 80 DNLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLadASPL---KPeivAGLDILIVRELTGGIYFGEPRGREGLGGEE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 156 FVTQQTVMTRTGVDRILKFAFELAQSRpKKHLTSATKSNGISITMpYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHP 235
Cdd:PRK00772 156 RAFDTMVYTREEIERIARVAFELARKR-RKKVTSVDKANVLESSR-LWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 236 DWFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPEGdfPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEH-LGE 314
Cdd:PRK00772 234 KQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESG--PGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYsLGL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 517126793 315 KEAGQSIVEAIERTLAERtLRTKDL---GGNADTTACGKAVAD 354
Cdd:PRK00772 312 EEAADAIEAAVEKVLAQG-YRTADIaegGGKVSTSEMGDAILA 353
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
7-352 |
8.11e-105 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 311.54 E-value: 8.11e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 7 RIAVIPGDGIGKEVMPEGLRVLEAAAKKHGVSLQFDHFDFSSwDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWPAKIPD 86
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGG-AAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 87 HVSLWGSLIKFRREFDQYVNLRPVRLMP--GVPSPLAgRKPGDIDFWVVRENTEGEYSSVGgRMFPDTDREFVTQQTVMT 164
Cdd:pfam00180 80 GVRPENGLLALRKELGLFANLRPAKVFPplGDASPLK-NEVEGVDIVIVRELTGGIYFGIE-KGIKGSGNEVAVDTKLYS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 165 RTGVDRILKFAFELAQSRPKKHLTSATKSNgISITMPYWDERVEAMAK-KFPGVKWDKYHIDILTANFVLHPDWFDVVVG 243
Cdd:pfam00180 158 RDEIERIARVAFELARKRGRKKVTSVDKAN-VLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVIVT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 244 SNLFGDILSDLGPACTGTIGIAPSGNINPEGdfPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEH-LGEKEAGQSIV 322
Cdd:pfam00180 237 PNLFGDILSDEASMLTGSLGLLPSASLGANG--FGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIE 314
|
330 340 350
....*....|....*....|....*....|...
gi 517126793 323 EAIERTLAERTlRTKDLGGNAD---TTACGKAV 352
Cdd:pfam00180 315 AAVLKVLESGI-RTGDLAGSATyvsTSEFGEAV 346
|
|
| LEU3_arch |
TIGR02088 |
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ... |
8-353 |
1.21e-96 |
|
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.
Pssm-ID: 273962 Cd Length: 322 Bit Score: 289.74 E-value: 1.21e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 8 IAVIPGDGIGKEVMPEGLRVLEAaakkhgVSLQFDHFDFSSWD-YYEKHGQMMPDDWKEKIGKHDAIYFGAVGWPAKiPD 86
Cdd:TIGR02088 1 VAVIPGDGIGPEVIEAAIRILNK------LGLEIEFIEFEAGDeALKKYGSALPEDTLEEIRKADAILFGAVTTPAN-PG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 87 HVSLwgsLIKFRREFDQYVNLRPVRLMPGVPsplaGRKPGDIDFWVVRENTEGEYSSVGgRMFPDTDREFvtqqTVMTRT 166
Cdd:TIGR02088 74 YKSV---IVTLRKELDLYANVRPAKSLPGIP----DLYPNGKDIVIVRENTEGLYAGFE-FGFSDRAIAI----RVITRE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 167 GVDRILKFAFELAQSRPKKhLTSATKSNGISITMPYWDERVEAMAKKFpGVKWDKYHIDILTANFVLHPDWFDVVVGSNL 246
Cdd:TIGR02088 142 GSERIARFAFNLAKERNRK-VTCVHKANVLKGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTNM 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 247 FGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSIVEAIE 326
Cdd:TIGR02088 220 FGDILSDLASALAGSLGLAPSANI---GDRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVE 296
|
330 340
....*....|....*....|....*..
gi 517126793 327 RTLAErTLRTKDLGGNADTTACGKAVA 353
Cdd:TIGR02088 297 YYIIE-GKKTPDLGGTAKTKEVGDEIA 322
|
|
| AksF2_Meth |
NF040626 |
homoisocitrate dehydrogenase; |
6-352 |
7.87e-96 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468598 Cd Length: 332 Bit Score: 288.17 E-value: 7.87e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 6 YRIAVIPGDGIGKEVMPEGLRVLEAaakkhgVSLQFDHFD-FSSWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVgwpAKI 84
Cdd:NF040626 2 YKITVIPGDGIGKEVMEAALYVLDA------LDLNFDFIEaEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV---TST 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 85 PDHVSlwgSLIKFRREFDQYVNLRPVRLMPGVPSPLAgrkpgDIDFWVVRENTEGEYSSVGGRmfpdTDREFVTQQTVMT 164
Cdd:NF040626 73 PGQKS---PIITLRKELDLYANLRPIKSYEGINCLFK-----DLDFLIVRENTEGLYSGLEEE----YTEEKAIAERVIT 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 165 RTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVVVGS 244
Cdd:NF040626 141 RKASERICKFAFEYAIKLGRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTT 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 245 NLFGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSIVEA 324
Cdd:NF040626 221 NLFGDILSDEAAGLVGGLGLAPSANI---GDKNGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENA 297
|
330 340
....*....|....*....|....*...
gi 517126793 325 IERTLAERTLRTKDLGGNADTTACGKAV 352
Cdd:NF040626 298 LEKVLREGKVVTPDLGGNAKTMEMANEI 325
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
6-356 |
8.88e-95 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 285.49 E-value: 8.88e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 6 YRIAVIPGDGIGKEVMPEGLRVLEAAakkhGVSLQFDHFDFSSwDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWPAKip 85
Cdd:PRK14025 2 HKICVIEGDGIGKEVVPAALHVLEAT----GLPFEFVYAEAGD-EVFEKTGKALPEETIEAAKEADAVLFGAAGETAA-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 86 dhvslwGSLIKFRREFDQYVNLRPVRLMPGVPSplagRKPgDIDFWVVRENTEGEYSSVGGrmfpDTDREFVTQQTVMTR 165
Cdd:PRK14025 75 ------DVIVKLRRILDTYANVRPVKSYKGVKC----LYP-DIDYVIVRENTEGLYKGIEA----EIADGVTVATRVITR 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 166 TGVDRILKFAFELAQSRPK----KHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVV 241
Cdd:PRK14025 140 KASERIFRFAFEMAKRRKKmgkeGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 242 VGSNLFGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSI 321
Cdd:PRK14025 220 VTSNLFGDILSDGAAGLVGGLGLAPSANI---GDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKV 296
|
330 340 350
....*....|....*....|....*....|....*
gi 517126793 322 VEAIERTLAERtLRTKDLGGNADTTACGKAVADMV 356
Cdd:PRK14025 297 EKALEEVLALG-LTTPDLGGNLSTMEMAEEVAKRV 330
|
|
| leuB |
TIGR00169 |
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ... |
7-356 |
4.93e-87 |
|
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272939 Cd Length: 346 Bit Score: 266.19 E-value: 4.93e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 7 RIAVIPGDGIGKEVMPEGLRVLEAAAKKHGVSLQFDHFDFSSwDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWPA--KI 84
Cdd:TIGR00169 1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGG-AAIDATGQPLPEETLKGCKEADAVLLGAVGGPKwdNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 85 PDHVSLWGSLIKFRREFDQYVNLRPVRLMPGVP--SPLAGRKPGDIDFWVVRENTEGEYssVGGRMFPDTDREFVTQQtV 162
Cdd:TIGR00169 80 PRDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEdlSPLKEEIAKGVDFVVVRELTGGIY--FGEPKGREGEGEAWDTE-V 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 163 MTRTGVDRILKFAFELAQSRpKKHLTSATKSNGISITMpYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVVV 242
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKR-RKKVTSVDKANVLESSR-LWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 243 GSNLFGDILSDLGPACTGTIGIAPSGNINpeGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEH-LGEKEAGQSI 321
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLG--SDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYsFNLEEAADAI 312
|
330 340 350
....*....|....*....|....*....|....*
gi 517126793 322 VEAIERTLAErTLRTKDLGGNADTTACGKAVADMV 356
Cdd:TIGR00169 313 EAAVKKVLAE-GYRTPDLGSSATTAVGTAEMGEEL 346
|
|
| AksF_Meth |
NF040619 |
homoisocitrate dehydrogenase; |
6-352 |
3.95e-82 |
|
homoisocitrate dehydrogenase;
Pssm-ID: 468591 Cd Length: 332 Bit Score: 253.14 E-value: 3.95e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 6 YRIAVIPGDGIGKEVMPEGLRVLEaaakkhgvslQFDHFDF----SSWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWP 81
Cdd:NF040619 2 PKICVIEGDGIGKEVIPETVRVLK----------ELGDFEFikgeAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 82 AKIPDHVSLWGS-LIKFRREFDQYVNLRPVRLMPgvpsplAGRKPGDIDFWVVRENTEGEYSsvgGRMFPDTDREFVTQQ 160
Cdd:NF040619 72 KPTELKNKNYKSpILTLRKELDLYANVRPINNFG------DGQDVKNIDFVIIRENTEGLYV---GREYYDEENEIAIAE 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 161 TVMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKKF--PGVKWDKYHIDILTANFVLHPDWF 238
Cdd:NF040619 143 RIISKKGSERIIKFAFEYAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEMF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 239 DVVVGSNLFGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAG 318
Cdd:NF040619 223 DVIVTTNLFGDILSDEASGLIGGLGLAPSANI---GDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKG 299
|
330 340 350
....*....|....*....|....*....|....
gi 517126793 319 QSIVEAIERTLAERTLrTKDLGGNADTTACGKAV 352
Cdd:NF040619 300 DLIREAVKKCLENGKV-TPDLGGNLKTKEVTDKI 332
|
|
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
7-354 |
3.59e-76 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 238.08 E-value: 3.59e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 7 RIAVIPGDGIGKEVMPEGLRVLEAAakkhGVSLQFDHFDfSSWDYYEKHGQMMPDDWKEKIGKHDAIYFGAVGWP----- 81
Cdd:PRK08997 4 TITVIPGDGIGPSIIDATLKILDKL----GCDFEYEFAD-AGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPvgegf 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 82 AKIpdHVSLwgslikfRREFDQYVNLRPVRLMPGVPSplagrKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREFVTqqT 161
Cdd:PRK08997 79 TSI--NVTL-------RKKFDLYANVRPVLSFPGTKA-----RYDNIDIITVRENTEGMYSGEGQTVSEDGETAEAT--S 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 162 VMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVV 241
Cdd:PRK08997 143 IITRKGAERIVRFAYELARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 242 VGSNLFGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSI 321
Cdd:PRK08997 223 VTTNLFGDILSDLCAGLVGGLGMAPGANI---GRDAAIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERI 299
|
330 340 350
....*....|....*....|....*....|...
gi 517126793 322 VEAIERTLAERTLRTKDLGGNADTTACGKAVAD 354
Cdd:PRK08997 300 RKAIVAVIEAGDRTTRDLGGTHGTTDFTQAVID 332
|
|
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
6-352 |
3.52e-70 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 222.64 E-value: 3.52e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 6 YRIAVIPGDGIGKEVMPEGLRVLEAAakkhGVSLQFDHFDFSSwdyyEKHGQMM-PDDWKEKIGKHDAIYFGAVGWPAKI 84
Cdd:TIGR00175 4 YTVTLIPGDGIGPEISGSVKKIFRAA----NVPIEFEEIDVSP----QTDGKTEiPDEAVESIKRNKVALKGPLETPIGK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 85 PDHVSLWGSLikfRREFDQYVNLRPVRLMPGVPSPLAgrkpgDIDFWVVRENTEGEYSSVGGRMFPDTdrefVTQQTVMT 164
Cdd:TIGR00175 76 GGHRSLNVAL---RKELDLYANVVHCKSLPGFKTRHE-----DVDIVIIRENTEGEYSGLEHESVPGV----VESLKVIT 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 165 RTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVVVGS 244
Cdd:TIGR00175 144 RDKSERIARYAFEYARKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 245 NLFGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEP-VHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSIVE 323
Cdd:TIGR00175 224 NLYGNILSNLGAGLVGGPGLVPGANI---GRDYAVFEPgVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQK 300
|
330 340
....*....|....*....|....*....
gi 517126793 324 AIERTLAERTLRTKDLGGNADTTACGKAV 352
Cdd:TIGR00175 301 AVLSTIAEGKNRTKDLGGTATTSDFTEAV 329
|
|
| PRK09222 |
PRK09222 |
NADP-dependent isocitrate dehydrogenase; |
8-331 |
3.79e-59 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236416 [Multi-domain] Cd Length: 482 Bit Score: 198.19 E-value: 3.79e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 8 IAVIPGDGIGKEVMPEGLRVLEAAakkhGVSLqfdhfdfsSWDYYEkhgqmmpddwkekIGkhDAIYfgAVGWPAKIPDh 87
Cdd:PRK09222 7 ITVAYGDGIGPEIMEAVLKILEAA----GAPL--------EIETIE-------------IG--EKVY--KKGWTSGISP- 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 88 vSLWGSL-----------------------IKFRREFDQYVNLRPVR-LMPGVPSPLAGrkpgdIDFWVVRENTEGEYSS 143
Cdd:PRK09222 57 -SAWESIrrtkvllkapittpqgggykslnVTLRKTLGLYANVRPCVsYHPFVETKHPN-----LDVVIIRENEEDLYAG 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 144 VGGRMFPDtdrefVTQQT-VMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISITmpywD---ERV-EAMAKKFPGVK 218
Cdd:PRK09222 131 IEHRQTPD-----VYQCLkLISRPGSEKIIRYAFEYARANGRKKVTCLTKDNIMKLT----DglfHKVfDEIAKEYPDIE 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 219 WDKYHIDILTANFVLHPDWFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEPVHGSAPDIAGQGVANP 298
Cdd:PRK09222 202 AEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANI---GEEYAMFEAVHGSAPDIAGKNIANP 278
|
330 340 350
....*....|....*....|....*....|...
gi 517126793 299 IGAIWSGAMMLEHLGEKEAGQSIVEAIERTLAE 331
Cdd:PRK09222 279 SGLLNAAVMMLVHIGQFDIAELIENAWLKTLED 311
|
|
| PLN00118 |
PLN00118 |
isocitrate dehydrogenase (NAD+) |
2-354 |
4.56e-53 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062 Cd Length: 372 Bit Score: 179.30 E-value: 4.56e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 2 SKKQYRIAVIPGDGIGKEVMPEGLRVLEAAakkhGVSLQFD-HFDFSSWDyyEKHGQMMPDDWKEKIGKHDAIYFGAVGW 80
Cdd:PLN00118 38 SSTPITATLFPGDGIGPEIAESVKQVFTAA----GVPIEWEeHYVGTTVD--PRTGSFLTWESLESVRRNKVGLKGPMAT 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 81 PAKiPDHVSLWGSLikfRREFDQYVNLRPVRLMPGVPSplagrKPGDIDFWVVRENTEGEYSSVGGRMFPDTdrefVTQQ 160
Cdd:PLN00118 112 PIG-KGHRSLNLTL---RKELGLYANVRPCYSLPGYKT-----RYDDVDLVTIRENTEGEYSGLEHQVVRGV----VESL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 161 TVMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDV 240
Cdd:PLN00118 179 KIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 241 VVGSNLFGDILSDLGPACTGTIGIAPSGNINPEGdfPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQS 320
Cdd:PLN00118 259 LVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENG--LALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQ 336
|
330 340 350
....*....|....*....|....*....|....
gi 517126793 321 IVEAIERTLAERTLRTKDLGGNADTTACGKAVAD 354
Cdd:PLN00118 337 IHNAILNTIAEGKYRTADLGGSSTTTDFTKAICD 370
|
|
| PLN02329 |
PLN02329 |
3-isopropylmalate dehydrogenase |
3-339 |
2.09e-52 |
|
3-isopropylmalate dehydrogenase
Pssm-ID: 215188 Cd Length: 409 Bit Score: 178.73 E-value: 2.09e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 3 KKQYRIAVIPGDGIGKEVMPEGLRVLEAAAKKHGVSLQFDHFDFSSwDYYEKHGQMMPDDWKEKIGKHDAIYFGAVG--- 79
Cdd:PLN02329 44 KKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGG-AALDLVGVPLPEETFTAAKQSDAILLGAIGgyk 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 80 WPaKIPDHVSLWGSLIKFRREFDQYVNLRPVRLMPGV--PSPLAGRKPGDIDFWVVRENTEGEY-SSVGGRMFPDTDREF 156
Cdd:PLN02329 123 WD-KNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLvdASTLKKEVAEGVDMMIVRELTGGIYfGEPRGITINENGEEV 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 157 VTQQTVMTRTGVDRILKFAFELAQSRPKKhLTSATKSNGISITMpYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPD 236
Cdd:PLN02329 202 GVSTEIYAAHEIDRIARVAFETARKRRGK-LCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPK 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 237 WFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPEGdfPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEH-LGEK 315
Cdd:PLN02329 280 QFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESG--PGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEE 357
|
330 340
....*....|....*....|....
gi 517126793 316 EAGQSIVEAIERTLaERTLRTKDL 339
Cdd:PLN02329 358 KAAKRIEDAVVDAL-NKGFRTGDI 380
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
8-339 |
2.69e-51 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 175.68 E-value: 2.69e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 8 IAVIPGDGIGKEVMPEGLRVLEAAAKK-HGVSLQFDhfdfssWDYY---EKH----GQMMPDDWKEKIGKHdaiyfgavg 79
Cdd:COG0538 21 IPFIEGDGIGPEITRAIWKVIDAAVEKaYGGKRDIE------WKEVdagEKArdetGDWLPDETAEAIKEY--------- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 80 wpakipdHVSLWGSLI------------KFRREFDQYVNLRPVRLMPGVPSPLagRKPGDIDFWVVRENTEGEYS----S 143
Cdd:COG0538 86 -------GVGIKGPLTtpvgggwrslnvTIRQILDLYVCRRPVRYFKGVPSPV--KHPEKVDIVIFRENTEDIYAgiewK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 144 VGG------RMFPDTDREFVTQ---------QTVMTRTGVDRILKFAFELAQSRPKKHLTSATKSNgIS----------- 197
Cdd:COG0538 157 AGSpealklIFFLEDEMGVTVIrfpedsgigIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGN-IMkftegafkdwg 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 198 ------------ITMPYWDERVEAMAKKfpGVKWDKYHIDILTANFVLHPDWFDVVVGSNLFGDILSDLGPACTGTIGIA 265
Cdd:COG0538 236 yevaeeefgdkfITEGPWEKYKGPKPAG--KIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIA 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517126793 266 PSGNINPEGDFpsVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSIVEAIERTLAERTLrTKDL 339
Cdd:COG0538 314 PGANIGDDGGA--EFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKV-TYDL 384
|
|
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
8-357 |
4.89e-44 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 155.41 E-value: 4.89e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 8 IAVIPGDGIGKEVMPEGLRVLEAAAKKhgvslqfdhfdfSSWDYYEKHGQMM--PDDWKEKIGKHDAIYFGAVGWPakIP 85
Cdd:PLN00123 33 VTLIPGDGIGPLVTGAVEQVMEAMHAP------------VYFERYEVHGDMKkvPEEVLESIRRNKVCLKGGLATP--VG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 86 DHVSlwgSL-IKFRREFDQYVNLRPVRLMPGVPSplagrKPGDIDFWVVRENTEGEYSSVGGRMFPDTdrefVTQQTVMT 164
Cdd:PLN00123 99 GGVS---SLnVQLRKELDLFASLVNCFNLPGLPT-----RHENVDIVVIRENTEGEYSGLEHEVVPGV----VESLKVIT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 165 RTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKKFPGVKWDKYHIDILTANFVLHPDWFDVVVGS 244
Cdd:PLN00123 167 KFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 245 NLFGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEPVHGSA----PDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQS 320
Cdd:PLN00123 247 NLYGNLVANTAAGIAGGTGVMPGGNV---GADHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRHLQFPSFADR 323
|
330 340 350
....*....|....*....|....*....|....*..
gi 517126793 321 IVEAIERTLAERTLRTKDLGGNADTTACGKAVADMVD 357
Cdd:PLN00123 324 LETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANLD 360
|
|
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
8-333 |
2.13e-38 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 141.35 E-value: 2.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 8 IAVIPGDGIGKEVMPEGLRVLEAAAKK-HGVSLQFDHFD-FSSWDYYEKHGqmmPDDW--KEKIgkhDAI--YFGAVGWP 81
Cdd:PRK07006 22 IPFIEGDGIGPDITPAMLKVVDAAVEKaYKGERKISWMEiYAGEKATKVYG---EDVWlpEETL---DLIreYRVAIKGP 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 82 AKIPdhvsLWG---SL-IKFRREFDQYVNLRPVRLMPGVPSPLagRKPGDIDFWVVRENTEGEYS--------------- 142
Cdd:PRK07006 96 LTTP----VGGgirSLnVALRQELDLYVCLRPVRYFKGVPSPV--KRPEDTDMVIFRENSEDIYAgiewkagsaeakkvi 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 143 -------SVGGRMFPDTDREFVTQqtvMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISIT------MPYWDERVEA 209
Cdd:PRK07006 170 kflqeemGVKKIRFPETSGIGIKP---VSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTegafkdWGYQLAEEEF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 210 MAKKFPGVKWDKYH--------------IDILTANFVLHPDWFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINpegD 275
Cdd:PRK07006 247 GDELIDGGPWDKIKnpetgkeiivkdsiADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIN---D 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 517126793 276 FPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSIVEAIERTLAERT 333
Cdd:PRK07006 324 GHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKT 381
|
|
| PRK06451 |
PRK06451 |
NADP-dependent isocitrate dehydrogenase; |
8-339 |
5.88e-35 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803 Cd Length: 412 Bit Score: 132.26 E-value: 5.88e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 8 IAVIPGDGIGKEVMPEGLRVLEAA-AKKHGVSLQFDHFDFSSWDYYEK-HGQMMPDDWKEKIGKHDAIYFGAVGWPAKip 85
Cdd:PRK06451 26 ILYVEGDGIGPEITHAAMKVINKAvEKAYGSDREIKWVEVLAGDKAEKlTGNRFPKESEELIEKYRVLLKGPLETPIG-- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 86 dhvSLWGSL-IKFRREFDQYVNLRPVRLMPGVPSPLagRKPGDIDFWVVRENTEGEYSsvgGRMFP-DTD-----REFVT 158
Cdd:PRK06451 104 ---KGWKSInVAIRLMLDLYANIRPVKYIPGIESPL--KNPEKIDLIIFRENTDDLYR---GIEYPyDSEeakkiRDFLR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 159 QQ-------------TVMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDE---------------RVEAM 210
Cdd:PRK06451 176 KElgveveddtgigiKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREwayevalkefrdyvvTEEEV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 211 AKKFPGVKWDKYHI------DILTANFVLHPDWFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEPVH 284
Cdd:PRK06451 256 TKNYNGVPPSGKVIindriaDNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANI---GDTGGMFEAIH 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 517126793 285 GSAPDIAGQGVANPIGAIWSGAMMLEHLGEKEAGQSIVEAIERTLAERTLrTKDL 339
Cdd:PRK06451 333 GTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKV-TQDL 386
|
|
| PRK07362 |
PRK07362 |
NADP-dependent isocitrate dehydrogenase; |
8-339 |
2.45e-21 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 180944 Cd Length: 474 Bit Score: 94.78 E-value: 2.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 8 IAVIPGDGIGKEVMPEGLRVLEAA-AKKHGVSLQFDHFDFSSWDYY-EKHG--QMMPDDWKEKIGKhdaiYFGAVGWPAK 83
Cdd:PRK07362 31 IPFIRGDGTGVDIWPATQKVLDAAvAKAYGGERKINWFKVYAGDEAcDLYGtyQYLPEDTLEAIRE----YGVAIKGPLT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 84 IPDHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPSPlaGRKPGDIDFWVVRENTEGEY--------SSVGGRMFPDTDRE 155
Cdd:PRK07362 107 TPIGGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSP--HKNPEKLDVIVYRENTEDIYmgieweagDEIGDKLIKHLNEE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 156 FVTQQTVM----------------TRTGVDRILKFAFE--LAQSRPKKHLTSATKSNGISIT------------------ 199
Cdd:PRK07362 185 VIPASPELgkrqiplgsgigikpvSKTGSQRHIRRAIEhaLRLPGDKRHVTLVHKGNIMKYTegafrdwgyelattefrd 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 200 -----MPYW---------DERVEAMAKKF-PGV-----------------------------KW-DKYHIDILTANFVLH 234
Cdd:PRK07362 265 ecvteRESWilsnkeknpNISIEDNARMIePGYdsltpekkaaicaevkevldsiwsshgngKWkEKVLVDDRIADSIFQ 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517126793 235 -----PDWFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNInpeGDFPSVFEPVHGSAPDIAGQGVANPIGAIWSGAMML 309
Cdd:PRK07362 345 qiqtrPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANI---GDNAAIFEATHGTAPKHAGLDRINPGSVILSGVMML 421
|
410 420 430
....*....|....*....|....*....|
gi 517126793 310 EHLGEKEAGQSIVEAIERTLAERTLrTKDL 339
Cdd:PRK07362 422 EYLGWQEAADLITKGLSAAIANKQV-TYDL 450
|
|
| |
