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Conserved domains on  [gi|517167913|ref|WP_018356731|]
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hypoxanthine phosphoribosyltransferase [Rodentibacter pneumotropicus]

Protein Classification

phosphoribosyltransferase( domain architecture ID 10786076)

type I phosphoribosyltransferase similar to phosphoribosyltransferases with specificities for hypoxanthine, guanine, and/or xanthine

EC:  2.4.2.-
Gene Ontology:  GO:0016763|GO:0000166|GO:0046872|GO:0043174
PubMed:  11751055
SCOP:  4000253

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 1-179 2.24e-92

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


:

Pssm-ID: 440399  Cd Length: 176  Bit Score: 266.51  E-value: 2.24e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   1 MKKHHVDVLISEADVKARITSLGEEITSFYQQKqvnKLIVVGLLRGSFMFMADLVRELRLPIEIEFMTTSSYVSGMTTNH 80
Cdd:COG0634    1 MHDDIAEVLISEEEIQARVKELAAQITADYAGK---EPLVVGVLKGAFVFMADLLRALDFPLEIDFMHVSSYGGGTESSG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  81 DVKISKDLEGDIQGENVLIVEDIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRREVSVPVEWVGFEIPDEFVVGFGI 160
Cdd:COG0634   78 EVRILKDLDEDIEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRKVDVPADYVGFEIPDEFVVGYGL 157

                        170
                 ....*....|....*....
gi 517167913 161 DYAQQYRNLGYIGKVVLEE 179
Cdd:COG0634  158 DYAEYYRNLPYIYALKPEV 176
 
Name Accession Description Interval E-value
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 1-179 2.24e-92

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 266.51  E-value: 2.24e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   1 MKKHHVDVLISEADVKARITSLGEEITSFYQQKqvnKLIVVGLLRGSFMFMADLVRELRLPIEIEFMTTSSYVSGMTTNH 80
Cdd:COG0634    1 MHDDIAEVLISEEEIQARVKELAAQITADYAGK---EPLVVGVLKGAFVFMADLLRALDFPLEIDFMHVSSYGGGTESSG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  81 DVKISKDLEGDIQGENVLIVEDIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRREVSVPVEWVGFEIPDEFVVGFGI 160
Cdd:COG0634   78 EVRILKDLDEDIEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRKVDVPADYVGFEIPDEFVVGYGL 157

                        170
                 ....*....|....*....
gi 517167913 161 DYAQQYRNLGYIGKVVLEE 179
Cdd:COG0634  158 DYAEYYRNLPYIYALKPEV 176
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 8-176 1.23e-83

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 244.07  E-value: 1.23e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913    8 VLISEADVKARITSLGEEITSFYQQKQvnkLIVVGLLRGSFMFMADLVRELRLPIEIEFMTTSSYVSGMTTNHDVKISKD 87
Cdd:TIGR01203   1 VLIPEEQIKARIAELAKQITEDYAGKP---LVLLCVLKGSFPFFADLIRYIAVPVQVDFMAVSSYGNGMQSSGDVKILKD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   88 LEGDIQGENVLIVEDIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRREVSVPVEWVGFEIPDEFVVGFGIDYAQQYR 167
Cdd:TIGR01203  78 LDLDIKGKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKVDVKVDFVGFEIPDKFVVGYGLDYAERYR 157


                  ....*....
gi 517167913  168 NLGYIGKVV 176
Cdd:TIGR01203 158 NLPYIGVLE 166
PRK15423 PRK15423
hypoxanthine phosphoribosyltransferase; Provisional
 3-177 5.16e-78

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 185321  Cd Length: 178  Bit Score: 230.29  E-value: 5.16e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   3 KHHVDVLISEADVKARITSLGEEITSFYQQKQvNKLIVVGLLRGSFMFMADLVRELRLPIEIEFMTTSSYVSGMTTNHDV 82
Cdd:PRK15423   2 KHTVEVMIPEAEIKARIAELGRQITERYKDSG-SDMVLVGLLRGSFMFMADLCREVQVSHEVDFMTASSYGSGMSTTRDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  83 KISKDLEGDIQGENVLIVEDIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRREVSVPVEWVGFEIPDEFVVGFGIDY 162
Cdd:PRK15423  81 KILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVGYGIDY 160

                        170
                 ....*....|....*
gi 517167913 163 AQQYRNLGYIGKVVL 177
Cdd:PRK15423 161 AQRYRHLPYIGKVIL 175
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 22-138 2.18e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 84.37  E-value: 2.18e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  22 LGEEITSFYQQKQVNKLIVVGLLRGSFMFMADLVRELRLPIEieFMTTSSYVSGMTTNHDVKISKDLEGDIQGENVLIVE 101
Cdd:cd06223    1 AGRLLAEEIREDLLEPDVVVGILRGGLPLAAALARALGLPLA--FIRKERKGPGRTPSEPYGLELPLGGDVKGKRVLLVD 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 517167913 102 DIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRRE 138
Cdd:cd06223   79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA 115
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 30-162 1.55e-19

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 80.10  E-value: 1.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   30 YQQKQVNKLIVVGLLRGSFMFMADLVRelRLPIEIEFMTTSSYVSGMTTNHdvkISKDLEGDIQGENVLIVEDIIDTGYT 109
Cdd:pfam00156  23 NEDYGGKPDVVVGILRGGLPFAGILAR--RLDVPLAFVRKVSYNPDTSEVM---KTSSALPDLKGKTVLIVDDILDTGGT 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 517167913  110 LEKVREILNLRNPASLTICTLLDKPSRREVSVPVEWVGFEiPDEFVVGFGIDY 162
Cdd:pfam00156  98 LLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDKYDKRVDD-WIVFVVGFGLDE 149
 
Name Accession Description Interval E-value
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 1-179 2.24e-92

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 266.51  E-value: 2.24e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   1 MKKHHVDVLISEADVKARITSLGEEITSFYQQKqvnKLIVVGLLRGSFMFMADLVRELRLPIEIEFMTTSSYVSGMTTNH 80
Cdd:COG0634    1 MHDDIAEVLISEEEIQARVKELAAQITADYAGK---EPLVVGVLKGAFVFMADLLRALDFPLEIDFMHVSSYGGGTESSG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  81 DVKISKDLEGDIQGENVLIVEDIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRREVSVPVEWVGFEIPDEFVVGFGI 160
Cdd:COG0634   78 EVRILKDLDEDIEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRKVDVPADYVGFEIPDEFVVGYGL 157

                        170
                 ....*....|....*....
gi 517167913 161 DYAQQYRNLGYIGKVVLEE 179
Cdd:COG0634  158 DYAEYYRNLPYIYALKPEV 176
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 8-176 1.23e-83

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 244.07  E-value: 1.23e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913    8 VLISEADVKARITSLGEEITSFYQQKQvnkLIVVGLLRGSFMFMADLVRELRLPIEIEFMTTSSYVSGMTTNHDVKISKD 87
Cdd:TIGR01203   1 VLIPEEQIKARIAELAKQITEDYAGKP---LVLLCVLKGSFPFFADLIRYIAVPVQVDFMAVSSYGNGMQSSGDVKILKD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   88 LEGDIQGENVLIVEDIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRREVSVPVEWVGFEIPDEFVVGFGIDYAQQYR 167
Cdd:TIGR01203  78 LDLDIKGKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKVDVKVDFVGFEIPDKFVVGYGLDYAERYR 157


                  ....*....
gi 517167913  168 NLGYIGKVV 176
Cdd:TIGR01203 158 NLPYIGVLE 166
PRK15423 PRK15423
hypoxanthine phosphoribosyltransferase; Provisional
 3-177 5.16e-78

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 185321  Cd Length: 178  Bit Score: 230.29  E-value: 5.16e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   3 KHHVDVLISEADVKARITSLGEEITSFYQQKQvNKLIVVGLLRGSFMFMADLVRELRLPIEIEFMTTSSYVSGMTTNHDV 82
Cdd:PRK15423   2 KHTVEVMIPEAEIKARIAELGRQITERYKDSG-SDMVLVGLLRGSFMFMADLCREVQVSHEVDFMTASSYGSGMSTTRDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  83 KISKDLEGDIQGENVLIVEDIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRREVSVPVEWVGFEIPDEFVVGFGIDY 162
Cdd:PRK15423  81 KILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVGYGIDY 160

                        170
                 ....*....|....*
gi 517167913 163 AQQYRNLGYIGKVVL 177
Cdd:PRK15423 161 AQRYRHLPYIGKVIL 175
PLN02238 PLN02238
hypoxanthine phosphoribosyltransferase
 1-173 6.58e-59

hypoxanthine phosphoribosyltransferase


Pssm-ID: 215132  Cd Length: 189  Bit Score: 182.16  E-value: 6.58e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   1 MKKHHVDVLISEADVKARITSLGEEITSFYQQKqvnKLIVVGLLRGSFMFMADLVRELRL---PIEIEFMTTSSYVSGMT 77
Cdd:PLN02238   3 YEVDIEKVLWTAEDISARVAELAAQIASDYAGK---SPVVLGVATGAFMFLADLVRAIQPlprGLTVDFIRASSYGGGTE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  78 TNHDVKIS-KDLEGDIQGENVLIVEDIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRREVSVPV-----EWVGFEIP 151
Cdd:PLN02238  80 SSGVAKVSgADLKIDVKGKHVLLVEDIVDTGNTLSALVAHLEAKGAASVSVCALLDKRARRKVKYELvgdgkEYVGFECP 159

                        170       180
                 ....*....|....*....|..
gi 517167913 152 DEFVVGFGIDYAQQYRNLGYIG 173
Cdd:PLN02238 160 DEFVVGYGLDFAEKYRNLPYVG 181
PTZ00271 PTZ00271
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 9-169 5.83e-36

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 140297  Cd Length: 211  Bit Score: 124.36  E-value: 5.83e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   9 LISEADVKARITSLGEEITSFYQQKQV---NKLIVVGLLRGSFMFMADLVRELR---LPIEIEFMTTSSYVSGMTTNHDV 82
Cdd:PTZ00271  27 LVTQEQVWAATAKCAKKIAEDYRSFKLtteNPLYLLCVLKGSFIFTADLARFLAdegVPVKVEFICASSYGTGVETSGQV 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  83 KISKDLEGDIQGENVLIVEDIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRREVSVPVEWVGFEIPDEFVVGFGIDY 162
Cdd:PTZ00271 107 RMLLDVRDSVENRHILIVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIGYGMDY 186


                 ....*..
gi 517167913 163 AQQYRNL 169
Cdd:PTZ00271 187 AESYREL 193
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 8-169 1.15e-24

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 95.99  E-value: 1.15e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   8 VLISEADVKARITSLGEEITSFYQQKQvnkLIVVGLLRGSFMFMADLV-----------RELRLPIEIE-FMTTSSYVSG 75
Cdd:PTZ00149  56 ILLPNGLIKDRVEKLAYDIKQVYGNEE---LHILCILKGSRGFFSALVdylnrihnyssTESPKPPYQEhYVRVKSYCND 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  76 MTTNHDVKISKDLEGdIQGENVLIVEDIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRREVSVPVEWVGFEIPDEFV 155
Cdd:PTZ00149 133 ESTGKLEIVSDDLSC-LKDKHVLIVEDIIDTGNTLVKFCEYLKKFEPKTIRIATLFEKRTPLSNGFKGDFVGFSIPDHFV 211

                        170
                 ....*....|....
gi 517167913 156 VGFGIDYAQQYRNL 169
Cdd:PTZ00149 212 VGYCLDYNEHFRDL 225
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 22-138 2.18e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 84.37  E-value: 2.18e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  22 LGEEITSFYQQKQVNKLIVVGLLRGSFMFMADLVRELRLPIEieFMTTSSYVSGMTTNHDVKISKDLEGDIQGENVLIVE 101
Cdd:cd06223    1 AGRLLAEEIREDLLEPDVVVGILRGGLPLAAALARALGLPLA--FIRKERKGPGRTPSEPYGLELPLGGDVKGKRVLLVD 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 517167913 102 DIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRRE 138
Cdd:cd06223   79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA 115
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 4-172 3.30e-21

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 181675  Cd Length: 181  Bit Score: 85.30  E-value: 3.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   4 HHVDVLISEADVKARITSLGEEITSFYQQKqvNKLIVVgLLRGSFMFMADLVRELRLPIEIEFMTTSSYvSGMTTNHDVK 83
Cdd:PRK09162  11 AEADCLVSAAEVEAAIDRMADEITADLADE--NPLVLC-VMGGGLVFTGQLLPRLDFPLEFDYLHATRY-RNETTGGELV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  84 ISKDLEGDIQGENVLIVEDIIDTGYTLEKVREILNLRNPASLTICTLLDKPSRREVS-VPVEWVGFEIPDEFVVGFGIDY 162
Cdd:PRK09162  87 WKVKPRESLKGRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYSAVLVDKTHDRKAKpLKADFVGLEVPDRYVFGYGMDY 166

                        170
                 ....*....|
gi 517167913 163 AQQYRNLGYI 172
Cdd:PRK09162 167 KGYWRNLPGI 176
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 30-162 1.55e-19

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 80.10  E-value: 1.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913   30 YQQKQVNKLIVVGLLRGSFMFMADLVRelRLPIEIEFMTTSSYVSGMTTNHdvkISKDLEGDIQGENVLIVEDIIDTGYT 109
Cdd:pfam00156  23 NEDYGGKPDVVVGILRGGLPFAGILAR--RLDVPLAFVRKVSYNPDTSEVM---KTSSALPDLKGKTVLIVDDILDTGGT 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 517167913  110 LEKVREILNLRNPASLTICTLLDKPSRREVSVPVEWVGFEiPDEFVVGFGIDY 162
Cdd:pfam00156  98 LLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDKYDKRVDD-WIVFVVGFGLDE 149
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 39-137 5.16e-17

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 73.73  E-value: 5.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  39 IVVGLLRGSfMFMADLV-RELRLPiEIEFMTTSSYVSGMTTNHDVKISKDLEGDIQGENVLIVEDIIDTGYTLEKVREIL 117
Cdd:COG2236   34 VIVAIARGG-LVPARILaDALGVP-DLASIRVSSYTGTAKRLEEPVVKGPLDEDLAGKRVLIVDDVADTGRTLEAVRDLL 111

                         90       100
                 ....*....|....*....|
gi 517167913 118 NLRNPASLTICTLLDKPSRR 137
Cdd:COG2236  112 KEAGPAEVRTAVLYYKPSSK 131
PRK09177 PRK09177
xanthine-guanine phosphoribosyltransferase; Validated
 40-117 3.87e-08

xanthine-guanine phosphoribosyltransferase; Validated


Pssm-ID: 236395  Cd Length: 156  Bit Score: 50.25  E-value: 3.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517167913  40 VVGLLRGSFMFMADLVREL--RLpieIEFMTTSSYvsGMTTNHDVKISKDLEGDiqGENVLIVEDIIDTGYTLEKVREIL 117
Cdd:PRK09177  35 IIAVTRGGLVPAAILARELgiRL---VDTVCISSY--DHDNQGELKVLKRAEGD--GEGFLVVDDLVDTGGTARAVREMY 107
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 80-117 1.09e-04

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 41.50  E-value: 1.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 517167913   80 HDVKISKDLEGDIQGENVLIVEDIIDTGYTLEKVREIL 117
Cdd:TIGR01251 196 TNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEIL 233
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
90-117 4.72e-04

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 39.72  E-value: 4.72e-04
                         10        20
                 ....*....|....*....|....*...
gi 517167913  90 GDIQGENVLIVEDIIDTGYTLEKVREIL 117
Cdd:PRK01259 204 GDVEGRDCILVDDMIDTAGTLCKAAEAL 231
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 90-110 3.14e-03

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 36.96  E-value: 3.14e-03
                         10        20
                 ....*....|....*....|.
gi 517167913  90 GDIQGENVLIVEDIIDTGYTL 110
Cdd:COG0462  207 GDVEGKTCIIVDDMIDTGGTL 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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