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Conserved domains on  [gi|517309512|ref|WP_018498286|]
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amino acid ABC transporter permease [Leptotrichia wadei]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-215 1.83e-64

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 198.76  E-value: 1.83e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   1 MDFNFIIENIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIG 80
Cdd:COG0765    3 FDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  81 ITFNSHICAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSV 160
Cdd:COG0765   83 IDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 517309512 161 IGILALMELMYLTRDLIGLYYKTNESLFMLVAAYLIIILPVSFVLTVIERRIRYA 215
Cdd:COG0765  163 VSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-215 1.83e-64

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 198.76  E-value: 1.83e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   1 MDFNFIIENIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIG 80
Cdd:COG0765    3 FDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  81 ITFNSHICAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSV 160
Cdd:COG0765   83 IDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 517309512 161 IGILALMELMYLTRDLIGLYYKTNESLFMLVAAYLIIILPVSFVLTVIERRIRYA 215
Cdd:COG0765  163 VSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 2-212 6.70e-31

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 112.64  E-value: 6.70e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512    2 DFNFIIENIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIGI 81
Cdd:TIGR03003   2 DWEFVRQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   82 TFNSHICAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSVI 161
Cdd:TIGR03003  82 RLPALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 517309512  162 GILALMELMYLTRDLIGLYYKTNESLFMLVAAYLIIILPVSFVLTVIERRI 212
Cdd:TIGR03003 162 SAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
PRK15100 PRK15100
cystine ABC transporter permease;
3-196 7.02e-31

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 112.92  E-value: 7.02e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   3 FNFIIENIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIGIT 82
Cdd:PRK15100   5 IQLVIDSAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  83 FNSHICAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSVIG 162
Cdd:PRK15100  85 LDPIPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAA 164

                        170       180       190
                 ....*....|....*....|....*....|....
gi 517309512 163 ILALMELMyltRDLIGLYYKTNESLFMLVAAYLI 196
Cdd:PRK15100 165 TIQVPELF---RQAQLITSRTLEVFTMYLAASLI 195
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 17-203 1.18e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 66.53  E-value: 1.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  17 MRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIGITFNSH---ICAVMGL 93
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPglgLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  94 SFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSVIGILALMELMYLT 173
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 517309512 174 RDLIGLYYKTNESLFMLVAAYLIIILPVSF 203
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 31-214 2.50e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 54.61  E-value: 2.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   31 SILIGIVCALvlyYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIGITFNShICAVMGLSFLGGSYMCEAFRSGLE 110
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGI-LPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  111 SVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSVIGILALMELMYLTRDLIGLYYKTNE---SL 187
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEiqgPV 156

                         170       180
                  ....*....|....*....|....*..
gi 517309512  188 FMLVAAYLIIILPVSFVLTVIERRIRY 214
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRVRK 183
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-215 1.83e-64

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 198.76  E-value: 1.83e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   1 MDFNFIIENIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIG 80
Cdd:COG0765    3 FDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  81 ITFNSHICAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSV 160
Cdd:COG0765   83 IDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 517309512 161 IGILALMELMYLTRDLIGLYYKTNESLFMLVAAYLIIILPVSFVLTVIERRIRYA 215
Cdd:COG0765  163 VSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 1-212 1.98e-39

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 135.22  E-value: 1.98e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   1 MDFNFIIENIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIG 80
Cdd:COG4160    1 MDLDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  81 ITFNSHI---------CAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANI 151
Cdd:COG4160   81 WVRESWLwpllrdpwfCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEV 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517309512 152 IFLLKETSVIGILALMELMYLTRDLIGLYYKTNESLFMLVAAYLIIILPVSFVLTVIERRI 212
Cdd:COG4160  161 ILMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRL 221
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 2-212 6.70e-31

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 112.64  E-value: 6.70e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512    2 DFNFIIENIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIGI 81
Cdd:TIGR03003   2 DWEFVRQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   82 TFNSHICAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSVI 161
Cdd:TIGR03003  82 RLPALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 517309512  162 GILALMELMYLTRDLIGLYYKTNESLFMLVAAYLIIILPVSFVLTVIERRI 212
Cdd:TIGR03003 162 SAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
PRK15100 PRK15100
cystine ABC transporter permease;
3-196 7.02e-31

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 112.92  E-value: 7.02e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   3 FNFIIENIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIGIT 82
Cdd:PRK15100   5 IQLVIDSAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  83 FNSHICAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSVIG 162
Cdd:PRK15100  85 LDPIPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAA 164

                        170       180       190
                 ....*....|....*....|....*....|....
gi 517309512 163 ILALMELMyltRDLIGLYYKTNESLFMLVAAYLI 196
Cdd:PRK15100 165 TIQVPELF---RQAQLITSRTLEVFTMYLAASLI 195
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 2-213 9.00e-28

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 104.75  E-value: 9.00e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   2 DFNFIIENIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKI-- 79
Cdd:PRK09494   4 DWSAIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAfn 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  80 GITFNSHICAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETS 159
Cdd:PRK09494  84 DLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTS 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 517309512 160 VIGILALMELMYLTRDLIGLYYKTNESLFMLVAAYLIIILPVSFVLTVIERRIR 213
Cdd:PRK09494 164 LFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRMK 217
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 10-218 1.53e-25

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 98.77  E-value: 1.53e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   10 IPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIGITFNSHICA 89
Cdd:TIGR03004   4 LPLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIGLSLDPVTTG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   90 VMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSVIGILALMEL 169
Cdd:TIGR03004  84 VMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADL 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 517309512  170 MYLTRDLIGLYYKTNESLFMLVAAYLIIILPVSFVLTVIERRIRYATVG 218
Cdd:TIGR03004 164 TFAAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVVRRGNVF 212
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 9-107 2.02e-22

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 87.20  E-value: 2.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512    9 NIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIGITFNSHIC 88
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTA 80

                          90
                  ....*....|....*....
gi 517309512   89 AVMGLSFLGGSYMCEAFRS 107
Cdd:TIGR01726  81 AVIALTLFYGAYLAEIFRG 99
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
2-211 5.10e-17

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 76.41  E-value: 5.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   2 DFNFIIENIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKI-- 79
Cdd:PRK15107   5 DWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFlq 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  80 ---GITFNSHI---CAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIF 153
Cdd:PRK15107  85 nvlGLSPKTDIrliSAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIV 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 517309512 154 LLKETSVIGILALMELmYLTRDLIGLYYKTN-ESLFMLVAAYLIIILPVSFVLTVIERR 211
Cdd:PRK15107 165 LFQDTSLVYVLSLADF-FRTASTIGERDGTQvEMILFAGFVYFVISLSASLLVSYLKKR 222
artM PRK11122
arginine ABC transporter permease ArtM;
8-212 2.03e-14

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 69.22  E-value: 2.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   8 ENIPKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFG---LPKI----- 79
Cdd:PRK11122   3 EYLPELLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGpgqFPWLqeypw 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  80 --GITFNSHICAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLItNVILPQAFTVSFPAIAANIIFLLKE 157
Cdd:PRK11122  83 lwHLLSQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTL-RILLPYAFKRALSSYSNEVVLVFKS 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 517309512 158 TSVIGILALMELMYLTRDLIGLYYKTneslfMLVAAYLIIILPVSFVLTVIERRI 212
Cdd:PRK11122 162 TSLAYTITLMDVMGYSQLLYGRTYDV-----MVFGAAGIIYLVVNGLLTLLMRLI 211
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 17-203 1.18e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 66.53  E-value: 1.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  17 MRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIGITFNSH---ICAVMGL 93
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPglgLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  94 SFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSVIGILALMELMYLT 173
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 517309512 174 RDLIGLYYKTNESLFMLVAAYLIIILPVSF 203
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
29-211 5.48e-13

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 65.85  E-value: 5.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  29 VFSILIGIVCALVL----YYRVPAARQIVGIYIELSRNTPLVIQLFFLYFG------------------------LPKIG 80
Cdd:PRK11123  19 VCALIVGLALAMLFavweSAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGssqllltlsdgftlnlgfvqipvqMDIEN 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  81 ITFNSHICAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSV 160
Cdd:PRK11123  99 FEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVLLKDTAL 178

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 517309512 161 IGILALMELMYLTrDLIGLYYKTNESLFMLVAA-YLIIILPVSFVLTVIERR 211
Cdd:PRK11123 179 VSLISVNDLMLQT-KSIATRTQEPFTWYIIAAAiYLVITLISQYILKRIELR 229
PRK15069 PRK15069
histidine ABC transporter permease HisM;
13-211 4.56e-11

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 60.45  E-value: 4.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  13 YLEAMRLT-VIIGIFGIVFSILIGIVCALVLYY-RVPAARQI---VGIYIELSRNTPLVIQLFFLYFGLPKIGIT----- 82
Cdd:PRK15069  14 WTDGYRFTgLAITLWLLVASVVIGFVLAVPLAIaRVSSNKWIrfpVWLYTYVFRGTPLYVQLLVFYTGMYSLEIVrgtdl 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  83 ----FNSHI-CAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKE 157
Cdd:PRK15069  94 ldafFRSGLnCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHA 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 517309512 158 TSVIGILALMELMYLTRDLIGLYYKTNESLFMLVAAYLIIilpvSFVLTVIERR 211
Cdd:PRK15069 174 TTLAFTATVPDILKIARDINSATYQPFQAFGIAAVLYLII----SFVLISLFRR 223
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 31-214 2.50e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 54.61  E-value: 2.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512   31 SILIGIVCALvlyYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKIGITFNShICAVMGLSFLGGSYMCEAFRSGLE 110
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGI-LPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  111 SVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSVIGILALMELMYLTRDLIGLYYKTNE---SL 187
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEiqgPV 156

                         170       180
                  ....*....|....*....|....*..
gi 517309512  188 FMLVAAYLIIILPVSFVLTVIERRIRY 214
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRVRK 183
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
14-211 1.56e-08

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 52.87  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  14 LEAMRLTVIIGIFGIVFSILIGIVCALVLYYRVPAARQIVGIYIELSRNTPLVIQLFFLYFGLPKI-----------GIT 82
Cdd:PRK15135  10 LQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQIAlnsvtealgvgQID 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  83 FNSHICAVMGLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETSVIG 162
Cdd:PRK15135  90 IDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVS 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 517309512 163 ILALMELMYLTRdLIGlyYKTNESLFMLVAA---YLIIILPVSFVLTVIERR 211
Cdd:PRK15135 170 LLGLEDVVKATQ-LAG--KSTWEPFYFAIVCgviYLVFTTVSNGVLLWLERR 218
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 92-213 1.01e-07

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 51.30  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  92 GLSFLGGSYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQAFTVSFPAIAANIIFLLKETS---VIGilalme 168
Cdd:COG4597  271 ALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSlavAIG------ 344

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 517309512 169 lmYLtrDLIGLYYKT--N------ESLFMLVAAYLIIILPVSFVLTVIERRIR 213
Cdd:COG4597  345 --YP--DLVSVFAGTtlNqtgqaiEIIAITMAVYLTISLLISLLMNWYNRRVA 393
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 11-139 1.37e-03

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 38.59  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517309512  11 PKYLEAMRLTVIIGIFGIVFSILIGIVCALVLYyRVPAARQIVGIYIELSRNTPLV--IQLFFLYFGL---PKIGITFns 85
Cdd:COG0600   57 GELWEHLLASLLRVLLGFALAALLGVPLGLLLG-LSRLLRRLLDPLLVFLRPIPPLalAPLLILWFGIgeaSKIFVIF-- 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 517309512  86 hICAVMglsflggsYMCEAFRSGLESVTKGQRESGLSIGLTESQLITNVILPQA 139
Cdd:COG0600  134 -LGAFF--------PILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAA 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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