|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-471 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 761.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 1 MRRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 PVILERGDTFTLTVEEgVEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEGGVVSDHKGLNLP 160
Cdd:COG0469 82 PVELKKGDTFTLTTDD-VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 161 GAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRRLPVIAKVEKPQAVEDIEGIVAAFDGIMV 240
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 241 ARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKYPV 320
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 321 GAVHTMAKIVSAAEEDMLAGGLPPLTERDKPRTQGGAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRSPIPLLAFT 400
Cdd:COG0469 321 EAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517370859 401 PEPATRSQLSLTWGAETFLGPHVDSTDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGVSGTTNLVRVHHV 471
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
2-475 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 675.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 2 RRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEGP 81
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 82 VILERGDTFTLTVEEgVEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEGGVVSDHKGLNLPG 161
Cdd:PRK06247 85 VQLANGQTFRLDVDD-APGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 162 AAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVmdeEGRRLPVIAKVEKPQAVEDIEGIVAAFDGIMVA 241
Cdd:PRK06247 164 TVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 242 RGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKYPVG 321
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 322 AVHTMAKIVSAAEEDmlaGGLPPLTE--RDKPR-TQGGAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRSPIPLLA 398
Cdd:PRK06247 321 AVRTMARIIRQVERD---PTYPPLIHaqRPQPEaTKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILA 397
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517370859 399 FTPEPATRSQLSLTWGAETFLGPHVDSTDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGVSGTTNLVRVHHVGEDD 475
Cdd:PRK06247 398 LTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGEDD 474
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-468 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 574.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 2 RRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEGP 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 82 VILERGDTFTLTVEEG-VEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEGGVVSDHKGLNLP 160
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIkGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 161 GAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRR-LPVIAKVEKPQAVEDIEGIVAAFDGIM 239
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 240 VARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKYP 319
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 320 VGAVHTMAKIVSAAEEDMLAGGLPPLTERD--KPRTQGGAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRSPIPLL 397
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFNDRKNSdpKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517370859 398 AFTPEPATRSQLSLTWGAETFLGPH-VDSTDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGVSGTTNLVRV 468
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-471 |
3.63e-175 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 500.30 E-value: 3.63e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 1 MRRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 -PVILERGDTFTLTVEEG-VEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPR-VHTRVLEGGVVSDHKGL 157
Cdd:cd00288 81 kDISLKAGDKFLVTTDPAaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 158 NLPGAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRRLPVIAKVEKPQAVEDIEGIVAAFDG 237
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 238 IMVARGDLGVEMPLEHVPVVQK---RACQLARrnaKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETS 314
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKmliAKCNLAG---KPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 315 VGKYPVGAVHTMAKIVSAAEEDMLAGGL--PPLTERDKPRTQGGAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRS 392
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEKALSHRVLfnEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRP 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 393 PIPLLAFTPEPATRSQLSLTWGAETFLGPHV-----DSTDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGvSGTTNLVR 467
Cdd:cd00288 398 NAPIIAVTRNEQTARQLHLYRGVYPVLFEEPkpgwqEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMR 476
|
....
gi 517370859 468 VHHV 471
Cdd:cd00288 477 ILTV 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-334 |
1.22e-137 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 399.82 E-value: 1.22e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 1 MRRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 --PVILERGDTFTLTVEEGV--EGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGP-RVHTRVLEGGVVSDHK 155
Cdd:pfam00224 81 kkDIELKAGDEMIVSTDAKYkgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 156 GLNLPGAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRRLPVIAKVEKPQAVEDIEGIVAAF 235
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 236 DGIMVARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSV 315
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330
....*....|....*....
gi 517370859 316 GKYPVGAVHTMAKIVSAAE 334
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAE 339
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-471 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 761.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 1 MRRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG 80
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 PVILERGDTFTLTVEEgVEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEGGVVSDHKGLNLP 160
Cdd:COG0469 82 PVELKKGDTFTLTTDD-VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 161 GAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRRLPVIAKVEKPQAVEDIEGIVAAFDGIMV 240
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 241 ARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKYPV 320
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 321 GAVHTMAKIVSAAEEDMLAGGLPPLTERDKPRTQGGAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRSPIPLLAFT 400
Cdd:COG0469 321 EAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517370859 401 PEPATRSQLSLTWGAETFLGPHVDSTDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGVSGTTNLVRVHHV 471
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
2-475 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 675.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 2 RRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEGP 81
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 82 VILERGDTFTLTVEEgVEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEGGVVSDHKGLNLPG 161
Cdd:PRK06247 85 VQLANGQTFRLDVDD-APGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSLPG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 162 AAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVmdeEGRRLPVIAKVEKPQAVEDIEGIVAAFDGIMVA 241
Cdd:PRK06247 164 TVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 242 RGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKYPVG 321
Cdd:PRK06247 241 RGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 322 AVHTMAKIVSAAEEDmlaGGLPPLTE--RDKPR-TQGGAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRSPIPLLA 398
Cdd:PRK06247 321 AVRTMARIIRQVERD---PTYPPLIHaqRPQPEaTKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILA 397
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517370859 399 FTPEPATRSQLSLTWGAETFLGPHVDSTDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGVSGTTNLVRVHHVGEDD 475
Cdd:PRK06247 398 LTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYIGEDD 474
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
2-468 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 574.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 2 RRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEGP 81
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 82 VILERGDTFTLTVEEG-VEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEGGVVSDHKGLNLP 160
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIkGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 161 GAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRR-LPVIAKVEKPQAVEDIEGIVAAFDGIM 239
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 240 VARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKYP 319
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 320 VGAVHTMAKIVSAAEEDMLAGGLPPLTERD--KPRTQGGAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRSPIPLL 397
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFNDRKNSdpKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517370859 398 AFTPEPATRSQLSLTWGAETFLGPH-VDSTDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGVSGTTNLVRV 468
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-461 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 562.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 1 MRRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG 80
Cdd:PRK05826 3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 PVILERGDTFTLTVEEGVEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEGGVVSDHKGLNLP 160
Cdd:PRK05826 83 KITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINIP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 161 GAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGR-RLPVIAKVEKPQAVEDIEGIVAAFDGIM 239
Cdd:PRK05826 163 GGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAVDNIDEIIEASDGIM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 240 VARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKYP 319
Cdd:PRK05826 243 VARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYP 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 320 VGAVHTMAKIVSAAEEDmlagglpPLTERDKPRTQ------GGAVARAAAET-GDFLGARFLVAFTQSGDTARRLSRYRS 392
Cdd:PRK05826 323 VEAVEAMARICKGAEKE-------FSINLSKHRLDrqfdriDEAIAMSAMYAaNHLKGVKAIVALTESGRTARLISRFRP 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517370859 393 PIPLLAFTPEPATRSQLSLTWGAETFLGPHVDSTDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGVSG 461
Cdd:PRK05826 396 GAPIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-473 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 541.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 1 MRRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG 80
Cdd:PRK06354 7 MRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 PVILERGDTFTLTVEEgVEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGP--RVHTRVLEGGVVSDHKGLN 158
Cdd:PRK06354 87 PIELKTGDEFILTSRE-VLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKAdgELHCKVLVGGVLSNKKGVN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 159 LPGAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEE-GRRLPVIAKVEKPQAVEDIEGIVAAFDG 237
Cdd:PRK06354 166 FPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEKQEAIDNIDAILELCDG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 238 IMVARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGK 317
Cdd:PRK06354 246 LMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGD 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 318 YPVGAVHTMAKIVSAAEEDMLAggLPPLTERDKPRTQ-----GGAVARAAAEtgdfLGARFLVAFTQSGDTARRLSRYRS 392
Cdd:PRK06354 326 YPVEAVQTMATIAVRIEKDLPY--RDILSKRPEFTTTitnaiSQAVSHIALQ----LDAAAIVTLTKSGATARNVSKYRP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 393 PIPLLAFTPEPATRSQLSLTWGAETFLGPHVDSTDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGVSGTTNLVRVHHVG 472
Cdd:PRK06354 400 KTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVG 479
|
.
gi 517370859 473 E 473
Cdd:PRK06354 480 A 480
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
1-471 |
3.63e-175 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 500.30 E-value: 3.63e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 1 MRRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG 80
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 -PVILERGDTFTLTVEEG-VEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPR-VHTRVLEGGVVSDHKGL 157
Cdd:cd00288 81 kDISLKAGDKFLVTTDPAaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 158 NLPGAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRRLPVIAKVEKPQAVEDIEGIVAAFDG 237
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 238 IMVARGDLGVEMPLEHVPVVQK---RACQLARrnaKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETS 314
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKmliAKCNLAG---KPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 315 VGKYPVGAVHTMAKIVSAAEEDMLAGGL--PPLTERDKPRTQGGAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRS 392
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEKALSHRVLfnEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRP 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 393 PIPLLAFTPEPATRSQLSLTWGAETFLGPHV-----DSTDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGvSGTTNLVR 467
Cdd:cd00288 398 NAPIIAVTRNEQTARQLHLYRGVYPVLFEEPkpgwqEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMR 476
|
....
gi 517370859 468 VHHV 471
Cdd:cd00288 477 ILTV 480
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
1-469 |
2.56e-151 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 439.49 E-value: 2.56e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 1 MRRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG 80
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 P-VILERGDTFTLTVEEGVEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEGGVVSDHKGLNL 159
Cdd:PRK09206 81 NdVSLKAGQTFTFTTDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 160 PGAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEE-GRRLPVIAKVEKPQAVEDIEGIVAAFDGI 238
Cdd:PRK09206 161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHgGENIQIISKIENQEGLNNFDEILEASDGI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 239 MVARGDLGVEMPLEHVPVVQK---RACQLARrnaKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSV 315
Cdd:PRK09206 241 MVARGDLGVEIPVEEVIFAQKmmiEKCNRAR---KVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 316 GKYPVGAVHTMAKIVSAAEEDMLAGGLPPLTERDKPRTQggAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRSPIP 395
Cdd:PRK09206 318 GKYPLEAVSIMATICERTDRVMNSRLESNNDNRKLRITE--AVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDAT 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517370859 396 LLAFTPEPATRSQLSLTWGAETFLGPHVDSTDAMIAQVDELLLRYGRCEKGDMVVITAG--SPpgvSGTTNLVRVH 469
Cdd:PRK09206 396 ILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGalVP---SGTTNTASVH 468
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
1-334 |
1.22e-137 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 399.82 E-value: 1.22e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 1 MRRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG 80
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 --PVILERGDTFTLTVEEGV--EGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGP-RVHTRVLEGGVVSDHK 155
Cdd:pfam00224 81 kkDIELKAGDEMIVSTDAKYkgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 156 GLNLPGAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRRLPVIAKVEKPQAVEDIEGIVAAF 235
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 236 DGIMVARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSV 315
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330
....*....|....*....
gi 517370859 316 GKYPVGAVHTMAKIVSAAE 334
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAE 339
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
2-468 |
5.84e-124 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 371.02 E-value: 5.84e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 2 RRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRS-VGTLADLQGPKIRLGRFAEG 80
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARPNAnLGILLDTKGPEIRTGFLKNH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 -PVILERGDTFTLTVEEGVEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEGGVVSDHKGLNL 159
Cdd:PTZ00066 118 kPITLKEGQTLKITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 160 PGAAVSVPALTKKDEDD-LRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRRLPVIAKVEKPQAVEDIEGIVAAFDGI 238
Cdd:PTZ00066 198 PGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 239 MVARGDLGVEMPLEHVPVVQKraCQLARRN--AKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVG 316
Cdd:PTZ00066 278 MVARGDLGMEIPPEKVFLAQK--MMISKCNvaGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANG 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 317 KYPVGAVHTMAKIVSAAEE----DMLAGGLppLTERDKPRTQGGAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRS 392
Cdd:PTZ00066 356 KFPVEAVNIMAKICFEAETcidyRVLYHAI--HLAVPTPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRP 433
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517370859 393 PIPLLAFTPEPATRSQLSLTWGAETFLGPHVDSTDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGVSGTTNLVRV 468
Cdd:PTZ00066 434 SCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKV 509
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
3-450 |
1.16e-119 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 360.06 E-value: 1.16e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 3 RAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG-P 81
Cdd:PLN02461 22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGkP 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 82 VILERGDTFTLTVEEGVEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTS--VDGPRVHTRVLEGGVVSDHKGLNL 159
Cdd:PLN02461 102 VQLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAMLGERKNVNL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 160 PGAAVSVPALTKKDEDD-LRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRRLPVIAKVEKPQAVEDIEGIVAAFDGI 238
Cdd:PLN02461 182 PGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDILAESDAF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 239 MVARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKY 318
Cdd:PLN02461 262 MVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAY 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 319 PVGAVHTMAKIVSAAE----------EDMLAGGLP--PLTerdkprtqggAVARAAAETGDFLGARFLVAFTQSGDTARR 386
Cdd:PLN02461 342 PELAVKTMARICREAEasldygalfkEIMRSAPLPmsPLE----------SLASSAVRTANKVKASLIVVLTRGGTTARL 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 387 LSRYRSPIPLLA-FTPEPATRS------------QLSLTWGAETFLGP------HVDSTDAMIAQVDELLLRYGRCEKGD 447
Cdd:PLN02461 412 VAKYRPAVPILSvVVPEITTDSfdwscsdeaparHSLIYRGLIPVLAEgsakatDSESTEEILEAAIEHAKKKGLCKPGD 491
|
...
gi 517370859 448 MVV 450
Cdd:PLN02461 492 SVV 494
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
7-334 |
7.30e-99 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 301.09 E-value: 7.30e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 7 VCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADetgrSVGTLADLQGPKIRLGRFAEGPVILER 86
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDD----SIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 87 GDTFTLTVEEgVEGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEGGVVSDHKGLNLPGAAVSV 166
Cdd:PRK06739 82 GDSFILHTQP-VTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 167 PALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRRLP-VIAKVEKPQAVEDIEGIVAAFDGIMVARGDL 245
Cdd:PRK06739 161 PAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPnLIAKIETMEAIENFQDICKEADGIMIARGDL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 246 GVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKYPVGAVHT 325
Cdd:PRK06739 241 GVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVST 320
|
....*....
gi 517370859 326 MAKIVSAAE 334
Cdd:PRK06739 321 LRLVSEFAE 329
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
28-451 |
4.99e-98 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 302.35 E-value: 4.99e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 28 MDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEGPVILERGDTFTLTVEEGVE--GDRHHC 105
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAFAdkGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 106 GTTYAGLATDVTPGERVLVDDGRVCLEVTS-VDGPRVHTRVLEGGVVSDHKGLNLPGAAVSVPALTKKDEDDLRWALRTG 184
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVQShEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 185 FDTVALSFVRAGRDVLDVHRVMDEEGRRLPVIAKVEKPQAVEDIEGIVAAFDGIMVARGDLGVEMPLEHVPVVQK---RA 261
Cdd:PTZ00300 161 VDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKiliSK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 262 CQLArrnAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKYPVGAVHTMAKIV----SAAEEDM 337
Cdd:PTZ00300 241 CNVA---GKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICleaqSAVNEYV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 338 LAGGLPPLteRDKPRTQGGAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRSPIPLLAFTPEPATRSQLSLTWGAET 417
Cdd:PTZ00300 318 FFNSIKKL--QPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVES 395
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 517370859 418 F------LGpHVDSTDAMIAQVDELLLRYGRCEKGDMVVI 451
Cdd:PTZ00300 396 VffdaerLG-HDEGKEQRVAMGVGFAKSKGYVQSGDLMVV 434
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
2-457 |
8.99e-95 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 298.00 E-value: 8.99e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 2 RRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRR-AADETGRSVGTLADLQGPKIRLGRFAEg 80
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEyNAQSKDNVIAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 PVILERGDTFTLTVEEGVeGDRHHCGTTYAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEGGVVSDHKGLNLP 160
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRGV-STEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVR 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 161 GAAVSVPALTKKDEDDLRWALRTGFDTVALSFVRAGRDVLDVHRVMDEEGRRLPVIAKVEKPQAVEDIEGIVAAFDGIMV 240
Cdd:PLN02623 268 GKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIITASDGAMV 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 241 ARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKYPV 320
Cdd:PLN02623 348 ARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPL 427
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 321 GAVHTMAKIVSAAEEDMLAGGLPPLTERDKPRTQGGAVARAAAETGDFLGARFLVaFTQSGDTARRLSRYRSPIPLLAFT 400
Cdd:PLN02623 428 KAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTLGTSIIV-FTRTGFMAILLSHYRPSGTIFAFT 506
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 517370859 401 PEPATRSQLSLTWGAETFLGPHVDSTDAMIAQVDELLLRYGRCEKGDMV-VITAGSPP 457
Cdd:PLN02623 507 NEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVaLVQSGRQP 564
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
1-471 |
2.22e-92 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 289.72 E-value: 2.22e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 1 MRRAKIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRF-AE 79
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLgGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 80 GPVILERGDTFTLTVEEgVEGDRHHCGTT--YAGLATDVTPGERVLVDDGRVCLEVTSVDGPRVHTRVLEggvvsdhKGL 157
Cdd:PLN02762 104 SSAKAEDGEEWTFTVRK-FDGSRPEFTIQvnYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTD-------PGL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 158 NLPGAAVS--------------VPALTKKDEDDLRWALRTGFDTVALSFVRAGRDV--LDVHRVMDEEGRRLPVIAKVEK 221
Cdd:PLN02762 176 LLPRANLTfwrdgslvrernamLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIkhLKSYIAARSRDSDIGVIAKIES 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 222 PQAVEDIEGIVAAFDGIMVARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVL 301
Cdd:PLN02762 256 LDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVR 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 302 DGADAVMLSGETSVGKYPVGAVHTMaKIVS------AAEEDMLAG-GLPPLTERDKPRTqGGAVARAAAETGDFLGARFL 374
Cdd:PLN02762 336 QRADALMLSGESAMGLYPEKALSVL-RSVSlrmelwSREEKRHEAlELPQLSSSLSDRI-SEEICNSAAKMANNLGVDAI 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 375 VAFTQSGDTARRLSRYRSPIPLLAFTPEPATRSQLSLTWGAETFLGPHVDSTDAMIAQVDELLLRYGRCEKGDMVVITAG 454
Cdd:PLN02762 414 FVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIAVSD 493
|
490
....*....|....*..
gi 517370859 455 SPPgvSGTTNLVRVHHV 471
Cdd:PLN02762 494 LTP--SSMLQSIQVRNV 508
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
5-399 |
2.08e-77 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 251.13 E-value: 2.08e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 5 KIVCTLGPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEGPVIL 84
Cdd:PLN02765 31 KIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPISL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 85 ERGDTFTLTVEEGVEGDRHHCGTTYAGLATDVTPGERVLV--------DDGRVCLEVTSVDGPRV-----HTRVLEGGVV 151
Cdd:PLN02765 111 KAGNTVTLTPDQSKEASSEVLPINFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGDDVvctvkNSATLAGSLF 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 152 SDHkglnLPGAAVSVPALTKKDEDDLR-WALRTGFDTVALSFVRAGRDVLDVHRVMDEEG-RRLPVIAKVEKPQAVEDIE 229
Cdd:PLN02765 191 TLH----VSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIENVEGLTHFD 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 230 GIVAAFDGIMVARGDLGVEMPLEHVPVVQKRA---CQLArrnAKPVIVaTQMLDSMIENARPTRAEASDVANAVLDGADA 306
Cdd:PLN02765 267 EILQEADGIILSRGNLGIDLPPEKVFLFQKAAlykCNMA---GKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLDGADA 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 307 VMLSGETSVGKYPVGAVHTMAKIVSAAE---------EDMLAGGLPPLTERDkprtqggAVARAAAETGDFLGARFLVAF 377
Cdd:PLN02765 343 ILLGAETLRGLYPVETISTVGRICAEAEkvfnqdlyfKKTVKYVGEPMSHLE-------SIASSAVRAAIKVKASVIIVF 415
|
410 420
....*....|....*....|..
gi 517370859 378 TQSGDTARRLSRYRSPIPLLAF 399
Cdd:PLN02765 416 TSSGRAARLIAKYRPTMPVLSV 437
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
265-473 |
5.65e-56 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 188.96 E-value: 5.65e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 265 ARRNAKPVIVATQMLDSMIENARPTRAEASDVANAVLDGADAVMLSGETSVGKYPVGAVHTMAKIVSAAEEDMLAGGLPP 344
Cdd:COG3848 2 CNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 345 LTERDKPRTQGGAVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRSPIPLLAFTPEPATRSQLSLTWGAETFLGPHVD 424
Cdd:COG3848 82 PRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEESA 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 517370859 425 STDAMIAQVDELLLRYGRCEKGDMVVITAGSPPGVSGTTNLVRVHHVGE 473
Cdd:COG3848 162 STDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGD 210
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
2-329 |
4.69e-53 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 185.99 E-value: 4.69e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 2 RRAKIVCTL-GPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG 80
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVAGP 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 PVI--LERGDTFTLTVEEGVEGDRHHCGT---TYAGLATDVTPGERVLVDDGRVCLEVTSVdGP-----RVhTRVLEGGV 150
Cdd:PRK08187 213 LGKtrLYTGDRLALVAQGPPRRIDEEHFQvtcTLPEILARLAVGARVWIDDGKLGARVERV-GPggallEV-THARPKGL 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 151 -VSDHKGLNLPGAAVSVPALTKKDEDDLRWALRTGfDTVALSFVRAGRDV------LDVHRVMDEegRRLPVIAKVEKPQ 223
Cdd:PRK08187 291 kLKPEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVealqaaLAARRPDDW--RKLGLVLKIETPR 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 224 AVEDIEGIVAAFDG-----IMVARGDLGVEMPLEHVPVVQKRACQLARRNAKPVIVATQMLDSMIENARPTRAEASDVAN 298
Cdd:PRK08187 368 AVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAM 447
|
330 340 350
....*....|....*....|....*....|.
gi 517370859 299 AvlDGADAVMLSGetsvGKYPVGAVHTMAKI 329
Cdd:PRK08187 448 A--ARAECVMLNK----GPYLVEAVTFLDDL 472
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
2-329 |
2.01e-46 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 170.13 E-value: 2.01e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 2 RRAKIVCTL-GPATDSYDQIKALVEAGMDVARFNLSHGGQAEHEARYQRVRRAADETGRSVGTLADLQGPKIRLGRFAEG 80
Cdd:PRK14725 139 RPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPIAPG 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 81 P-VI----------------------------------------------LERGDTFTLT-------------------- 93
Cdd:PRK14725 219 PrVIklrptrdalgrvltparlwltasespppspppgpvglpvdpewlarLEPGDELRFTdargkkrkltvtevddegvl 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 94 --------VEEGVE-------------------------GDR-------------------HHCGTTYAGLATDVTPGER 121
Cdd:PRK14725 299 aegsqtayLANGTLlrlgrhdstrvgglppveqklrlkvGDRlvltrddapgdpaqgdappARISCTLPEAFRAARVGER 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 122 VLVDDGRVCLEVTSVDGPRVHTRVL---EGGV-VSDHKGLNLPGAAVSVPALTKKDEDDLRWALRTGfDTVALSFVRAGR 197
Cdd:PRK14725 379 VWFDDGKIGAVVVKVEADEVELRITharPGGSkLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSFVRSPE 457
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 198 DVLDVHRVMDEEG-RRLPVIAKVEKPQAVEDI-----EGIVAAFDGIMVARGDLGVEMPLEHVPVVQKRACQLARRNAKP 271
Cdd:PRK14725 458 DVRLLLDALEKLGaDDLGVVLKIETRRAFENLprillEAMRHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVP 537
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 517370859 272 VIVATQMLDSMIENARPTRAEASDVANAVLdgADAVMLSGetsvGKYPVGAVHTMAKI 329
Cdd:PRK14725 538 VIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLNK----GPHIVEAVRVLDDI 589
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
357-469 |
3.57e-36 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 129.52 E-value: 3.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517370859 357 AVARAAAETGDFLGARFLVAFTQSGDTARRLSRYRSPIPLLAFTPEPATRSQLSLTWGAETFLGPHVDSTDAMIAQVDEL 436
Cdd:pfam02887 2 AIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVKV 81
|
90 100 110
....*....|....*....|....*....|...
gi 517370859 437 LLRYGRCEKGDMVVITAGSPPGVSGTTNLVRVH 469
Cdd:pfam02887 82 AKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
|
|
| |
