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Conserved domains on  [gi|517413483|ref|WP_018585538|]
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lactonase family protein [Salinispora arenicola]

Protein Classification

lactonase family protein( domain architecture ID 11457674)

lactonase family protein similar to 6-phosphogluconolactonase which\ncatalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid in the oxidative phase of the pentose phosphate pathway

CATH:  2.130.10.10
Gene Ontology:  GO:0052689
SCOP:  4002745|4000933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
7-345 1.93e-134

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


:

Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 386.95  E-value: 1.93e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483   7 IVYVGCYTvgaGGHGEGIVAARRDLVSGALTPLGTAAATPAPSFLARHPELPVLYAVNEVTDGAVSAFRV-ASDGGLTAL 85
Cdd:COG2706    9 FVYVGTYT---SGESEGIYVFRLDTATGELTLLGLVAALGNPSFLALSPDGRFLYAVNEVDDGGVSAFRIdPADGTLTLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  86 GSRPTGGAEPCHLAVAPNGRHLFVANYGGGSVAVFPLDGQGMPEERTDLVRHEGHGLDPERQQTAHTHMVAPGREGWPLF 165
Cdd:COG2706   86 NTVSSGGASPCHLSVDPDGRFLFVANYGGGSVSVFPIDADGSLGEPVQVIQHEGSGPNPERQEGPHAHSVVFDPDGRFLY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 166 VVDLGTDSVYLYEFDAATGRLAPRAcRVPTAAGTGPRHVARHPDGRRCWLVGELDGSVVTYEFTTE-GALRQRGRVSA-- 242
Cdd:COG2706  166 VPDLGTDRIYVYRLDPATGKLPEPP-EVSLPPGSGPRHLAFHPNGRFAYVINELDSTVSVYAYDAAtGTLTLIQTVSTlp 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 243 SERPGHVQPSEIAVGPGGRFLYVANRGVGTIAVFALDGE--LPVRVAEVDSGGEWPRHFALV--GPNLYVADERADLIAV 318
Cdd:COG2706  245 EDFTGENWAADIHISPDGRFLYVSNRGHNSIAVFAIDADggKLTLVGHVPTGGKWPRDFAIDpdGRFLLVANQKSDNITV 324

                        330       340
                 ....*....|....*....|....*..
gi 517413483 319 FRVDPVTGVPVPAAEPVAVPSPTCVLP 345
Cdd:COG2706  325 FRIDADTGKLTPTGRSVPVPSPVCVAF 351
 
Name Accession Description Interval E-value
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
7-345 1.93e-134

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 386.95  E-value: 1.93e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483   7 IVYVGCYTvgaGGHGEGIVAARRDLVSGALTPLGTAAATPAPSFLARHPELPVLYAVNEVTDGAVSAFRV-ASDGGLTAL 85
Cdd:COG2706    9 FVYVGTYT---SGESEGIYVFRLDTATGELTLLGLVAALGNPSFLALSPDGRFLYAVNEVDDGGVSAFRIdPADGTLTLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  86 GSRPTGGAEPCHLAVAPNGRHLFVANYGGGSVAVFPLDGQGMPEERTDLVRHEGHGLDPERQQTAHTHMVAPGREGWPLF 165
Cdd:COG2706   86 NTVSSGGASPCHLSVDPDGRFLFVANYGGGSVSVFPIDADGSLGEPVQVIQHEGSGPNPERQEGPHAHSVVFDPDGRFLY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 166 VVDLGTDSVYLYEFDAATGRLAPRAcRVPTAAGTGPRHVARHPDGRRCWLVGELDGSVVTYEFTTE-GALRQRGRVSA-- 242
Cdd:COG2706  166 VPDLGTDRIYVYRLDPATGKLPEPP-EVSLPPGSGPRHLAFHPNGRFAYVINELDSTVSVYAYDAAtGTLTLIQTVSTlp 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 243 SERPGHVQPSEIAVGPGGRFLYVANRGVGTIAVFALDGE--LPVRVAEVDSGGEWPRHFALV--GPNLYVADERADLIAV 318
Cdd:COG2706  245 EDFTGENWAADIHISPDGRFLYVSNRGHNSIAVFAIDADggKLTLVGHVPTGGKWPRDFAIDpdGRFLLVANQKSDNITV 324

                        330       340
                 ....*....|....*....|....*..
gi 517413483 319 FRVDPVTGVPVPAAEPVAVPSPTCVLP 345
Cdd:COG2706  325 FRIDADTGKLTPTGRSVPVPSPVCVAF 351
Lactonase pfam10282
Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases ...
 7-341 1.77e-122

Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.


Pssm-ID: 431196 [Multi-domain]  Cd Length: 340  Bit Score: 356.15  E-value: 1.77e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483    7 IVYVGCYTVGAGghgEGIVAARRDLVSGALTPLGTAAATPAPSFLARHPELPVLYAVNEVTD-GAVSAFRVASDGG-LTA 84
Cdd:pfam10282   1 TLYVGTYTKGDS---KGIYVLTLDTETGALTLLGLVAEVGNPSYLALSPDGRTLYAVNEEGDqGGVAAFRIDPDSGaLTL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483   85 LGSRPTGGAEPCHLAVAPNGRHLFVANYGGGSVAVFPLDGQGMPEERTDLVRHEGHGLDPERQQTAHTHMVAPGREGWPL 164
Cdd:pfam10282  78 LNQVPTGGASPCHLSVDPDGRFLFVANYHGGSVSVFPLDADGSLGELSQVVQHEGSGPPPERQESPHPHSVDLTPDGKFL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  165 FVVDLGTDSVYLYEFDAATGRLAPRAcRVPTAAGTGPRHVARHPDGRRCWLVGELDGSVVTYEFTTE-GALRQRGRVSA- 242
Cdd:pfam10282 158 VVPDLGTDRVRVYKLDAGGGKLTPPA-SVQTPPGSGPRHLAFHPNGKYAYVVNELSSTVTVFEYDPAtGTFEELQTVSTl 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  243 -SERPGHVQPSEIAVGPGGRFLYVANRGVGTIAVFALD--GELPVRVAEVDSGGEWPRHFAL--VGPNLYVADERADLIA 317
Cdd:pfam10282 237 pEGFTGTNGAAAIRVSPDGKFLYVSNRGHDSIAVFAVDeaGGTLTLVERVSTEGDFPRDFNIdpDGKFLVVANQDSDNVT 316

                         330       340
                  ....*....|....*....|....
gi 517413483  318 VFRVDPVTGVPVPAAEPVAVPSPT 341
Cdd:pfam10282 317 VFRRDPETGKLTLLGKDIEVPEPV 340
PRK11028 PRK11028
6-phosphogluconolactonase; Provisional
 71-326 2.59e-28

6-phosphogluconolactonase; Provisional


Pssm-ID: 182912 [Multi-domain]  Cd Length: 330  Bit Score: 112.36  E-value: 2.59e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  71 VSAFRVASDGGLTALGSRPTGGAePCHLAVAPNGRHLFVANYGGGSVAVFPLDGQGMPEERTDLVrhegHGL-------- 142
Cdd:PRK11028  59 VLSYRIADDGALTFAAESPLPGS-PTHISTDHQGRFLFSASYNANCVSVSPLDKDGIPVAPIQII----EGLegchsani 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 143 DPERQQtahthmvapgregwpLFVVDLGTDSVYLYEFDAAtGRLAP-RACRVPTAAGTGPRHVARHPDGRRCWLVGELDG 221
Cdd:PRK11028 134 DPDNRT---------------LWVPCLKEDRIRLFTLSDD-GHLVAqEPAEVTTVEGAGPRHMVFHPNQQYAYCVNELNS 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 222 SVVTYE---FTTEGALRQRGRVSASERPGHVQPSEIAVGPGGRFLYVANRGVGTIAVFAL--DGELPVRVAEVDSgGEWP 296
Cdd:PRK11028 198 SVDVWQlkdPHGEIECVQTLDMMPADFSDTRWAADIHITPDGRHLYACDRTASLISVFSVseDGSVLSFEGHQPT-ETQP 276

                        250       260       270
                 ....*....|....*....|....*....|..
gi 517413483 297 RHFAL--VGPNLYVADERADLIAVFRVDPVTG 326
Cdd:PRK11028 277 RGFNIdhSGKYLIAAGQKSHHISVYEIDGETG 308
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 98-322 2.77e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 44.97  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  98 LAVAPNGRHLFVANYGGGSVAVFPLDGQgmpeertdLVRHEGH-GLDPERQQTAHTHMVAPGREgwpLFVVDLGTDSVYL 176
Cdd:cd14963   13 MGVAVSDGRIYVADTNNHRVQVFDYEGK--------FKKSFGGpGTGPGEFKYPYGIAVDSDGN---IYVADLYNGRIQV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 177 YEFDAA-TGRLAPRACRVpTAAGTGPRHVArhpDGRrcWLVGELDGSVVTYeFTTEGA-LRQRGRVSAseRPGHVQ-PSE 253
Cdd:cd14963   82 FDPDGKfLKYFPEKKDRV-KLISPAGLAID---DGK--LYVSDVKKHKVIV-FDLEGKlLLEFGKPGS--EPGELSyPNG 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517413483 254 IAVGPGGRfLYVANRGVGTIAVFALDGELpvrVAEVDSGGEWPRHFAL-----VGP--NLYVADERADLIAVFRVD 322
Cdd:cd14963  153 IAVDEDGN-IYVADSGNGRIQVFDKNGKF---IKELNGSPDGKSGFVNprgiaVDPdgNLYVVDNLSHRVYVFDEQ 224
 
Name Accession Description Interval E-value
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
7-345 1.93e-134

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 386.95  E-value: 1.93e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483   7 IVYVGCYTvgaGGHGEGIVAARRDLVSGALTPLGTAAATPAPSFLARHPELPVLYAVNEVTDGAVSAFRV-ASDGGLTAL 85
Cdd:COG2706    9 FVYVGTYT---SGESEGIYVFRLDTATGELTLLGLVAALGNPSFLALSPDGRFLYAVNEVDDGGVSAFRIdPADGTLTLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  86 GSRPTGGAEPCHLAVAPNGRHLFVANYGGGSVAVFPLDGQGMPEERTDLVRHEGHGLDPERQQTAHTHMVAPGREGWPLF 165
Cdd:COG2706   86 NTVSSGGASPCHLSVDPDGRFLFVANYGGGSVSVFPIDADGSLGEPVQVIQHEGSGPNPERQEGPHAHSVVFDPDGRFLY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 166 VVDLGTDSVYLYEFDAATGRLAPRAcRVPTAAGTGPRHVARHPDGRRCWLVGELDGSVVTYEFTTE-GALRQRGRVSA-- 242
Cdd:COG2706  166 VPDLGTDRIYVYRLDPATGKLPEPP-EVSLPPGSGPRHLAFHPNGRFAYVINELDSTVSVYAYDAAtGTLTLIQTVSTlp 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 243 SERPGHVQPSEIAVGPGGRFLYVANRGVGTIAVFALDGE--LPVRVAEVDSGGEWPRHFALV--GPNLYVADERADLIAV 318
Cdd:COG2706  245 EDFTGENWAADIHISPDGRFLYVSNRGHNSIAVFAIDADggKLTLVGHVPTGGKWPRDFAIDpdGRFLLVANQKSDNITV 324

                        330       340
                 ....*....|....*....|....*..
gi 517413483 319 FRVDPVTGVPVPAAEPVAVPSPTCVLP 345
Cdd:COG2706  325 FRIDADTGKLTPTGRSVPVPSPVCVAF 351
Lactonase pfam10282
Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases ...
 7-341 1.77e-122

Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.


Pssm-ID: 431196 [Multi-domain]  Cd Length: 340  Bit Score: 356.15  E-value: 1.77e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483    7 IVYVGCYTVGAGghgEGIVAARRDLVSGALTPLGTAAATPAPSFLARHPELPVLYAVNEVTD-GAVSAFRVASDGG-LTA 84
Cdd:pfam10282   1 TLYVGTYTKGDS---KGIYVLTLDTETGALTLLGLVAEVGNPSYLALSPDGRTLYAVNEEGDqGGVAAFRIDPDSGaLTL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483   85 LGSRPTGGAEPCHLAVAPNGRHLFVANYGGGSVAVFPLDGQGMPEERTDLVRHEGHGLDPERQQTAHTHMVAPGREGWPL 164
Cdd:pfam10282  78 LNQVPTGGASPCHLSVDPDGRFLFVANYHGGSVSVFPLDADGSLGELSQVVQHEGSGPPPERQESPHPHSVDLTPDGKFL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  165 FVVDLGTDSVYLYEFDAATGRLAPRAcRVPTAAGTGPRHVARHPDGRRCWLVGELDGSVVTYEFTTE-GALRQRGRVSA- 242
Cdd:pfam10282 158 VVPDLGTDRVRVYKLDAGGGKLTPPA-SVQTPPGSGPRHLAFHPNGKYAYVVNELSSTVTVFEYDPAtGTFEELQTVSTl 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  243 -SERPGHVQPSEIAVGPGGRFLYVANRGVGTIAVFALD--GELPVRVAEVDSGGEWPRHFAL--VGPNLYVADERADLIA 317
Cdd:pfam10282 237 pEGFTGTNGAAAIRVSPDGKFLYVSNRGHDSIAVFAVDeaGGTLTLVERVSTEGDFPRDFNIdpDGKFLVVANQDSDNVT 316

                         330       340
                  ....*....|....*....|....
gi 517413483  318 VFRVDPVTGVPVPAAEPVAVPSPT 341
Cdd:pfam10282 317 VFRRDPETGKLTLLGKDIEVPEPV 340
PRK11028 PRK11028
6-phosphogluconolactonase; Provisional
 71-326 2.59e-28

6-phosphogluconolactonase; Provisional


Pssm-ID: 182912 [Multi-domain]  Cd Length: 330  Bit Score: 112.36  E-value: 2.59e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  71 VSAFRVASDGGLTALGSRPTGGAePCHLAVAPNGRHLFVANYGGGSVAVFPLDGQGMPEERTDLVrhegHGL-------- 142
Cdd:PRK11028  59 VLSYRIADDGALTFAAESPLPGS-PTHISTDHQGRFLFSASYNANCVSVSPLDKDGIPVAPIQII----EGLegchsani 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 143 DPERQQtahthmvapgregwpLFVVDLGTDSVYLYEFDAAtGRLAP-RACRVPTAAGTGPRHVARHPDGRRCWLVGELDG 221
Cdd:PRK11028 134 DPDNRT---------------LWVPCLKEDRIRLFTLSDD-GHLVAqEPAEVTTVEGAGPRHMVFHPNQQYAYCVNELNS 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 222 SVVTYE---FTTEGALRQRGRVSASERPGHVQPSEIAVGPGGRFLYVANRGVGTIAVFAL--DGELPVRVAEVDSgGEWP 296
Cdd:PRK11028 198 SVDVWQlkdPHGEIECVQTLDMMPADFSDTRWAADIHITPDGRHLYACDRTASLISVFSVseDGSVLSFEGHQPT-ETQP 276

                        250       260       270
                 ....*....|....*....|....*....|..
gi 517413483 297 RHFAL--VGPNLYVADERADLIAVFRVDPVTG 326
Cdd:PRK11028 277 RGFNIdhSGKYLIAAGQKSHHISVYEIDGETG 308
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
98-314 1.61e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 60.48  E-value: 1.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  98 LAVAPNGRHLFVANYGGGSVAVFPLDGQGMPEERTDLVRHEGHGLDPerQQTAHTHMVAPGREGWPLFVVDLGTDSVYLy 177
Cdd:COG3391   18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGA--AAVADADGADAGADGRRLYVANSGSGRVSV- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 178 eFDAATGRLAPRacrvpTAAGTGPRHVARHPDGRRCWLVGELDGSVVTYEFTTegaLRQRGRVsaserPGHVQPSEIAVG 257
Cdd:COG3391   95 -IDLATGKVVAT-----IPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTAT---GKVVATI-----PVGAGPHGIAVD 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517413483 258 PGGRFLYVANRGVGTIAVF--ALDGELPVRVAEVDSGGEwPRHFALV--GPNLYVADERAD 314
Cdd:COG3391  161 PDGKRLYVANSGSNTVSVIvsVIDTATGKVVATIPVGGG-PVGVAVSpdGRRLYVANRGSN 220
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
26-272 1.25e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.78  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  26 AARRDLVSGALTPLGTAAATPAPSFLARHPELPVLYAVNEVTDGAVSAFRVASDGGLTALGSRPTGGAEPCHLAVAPNGR 105
Cdd:COG3391    1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 106 HLFVANYGGGSVAVFPLDGQgmpeertDLVRHEGHGLDPerqqtahtHMVAPGREGWPLFVVDLGTDSVYLyeFDAATGR 185
Cdd:COG3391   81 RLYVANSGSGRVSVIDLATG-------KVVATIPVGGGP--------RGLAVDPDGGRLYVADSGNGRVSV--IDTATGK 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 186 LApraCRVPTaaGTGPRHVARHPDGRRCWLVGELDG--SVVTYEFTTEgalrqRGRVSASERPGHvQPSEIAVGPGGRFL 263
Cdd:COG3391  144 VV---ATIPV--GAGPHGIAVDPDGKRLYVANSGSNtvSVIVSVIDTA-----TGKVVATIPVGG-GPVGVAVSPDGRRL 212


                 ....*....
gi 517413483 264 YVANRGVGT 272
Cdd:COG3391  213 YVANRGSNT 221
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
89-337 6.11e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 56.18  E-value: 6.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  89 PTGGAEPCHLAVAPNGRhLFVANYGGGSVAVF-PLDGQgmpeertdLVRHEGHGLdperqqtAHTHMVAPGREGwPLFVV 167
Cdd:COG4257   13 PAPGSGPRDVAVDPDGA-VWFTDQGGGRIGRLdPATGE--------FTEYPLGGG-------SGPHGIAVDPDG-NLWFT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 168 DLGTDSVylYEFDAATGRLApracRVPT-AAGTGPRHVARHPDGrRCWLVGELDGSVVTYEFTTegalrqrGRVSASERP 246
Cdd:COG4257   76 DNGNNRI--GRIDPKTGEIT----TFALpGGGSNPHGIAFDPDG-NLWFTDQGGNRIGRLDPAT-------GEVTEFPLP 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 247 -GHVQPSEIAVGPGGRfLYVANRGVGTIAVFALDGeLPVRVAEVDSGGEWPRHFAlVGP--NLYVADERADliAVFRVDP 323
Cdd:COG4257  142 tGGAGPYGIAVDPDGN-LWVTDFGANAIGRIDPDT-GTLTEYALPTPGAGPRGLA-VDPdgNLWVADTGSG--RIGRFDP 216

                        250       260
                 ....*....|....*....|
gi 517413483 324 VTG------VPVPAAEPVAV 337
Cdd:COG4257  217 KTGtvteypLPGGGARPYGV 236
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2-226 2.98e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 53.93  E-value: 2.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483   2 AGQGAIVYVGCYTVGAGGHGEGIVAARRDLVSGALTPLGTAAATPAPSFLARHPELPVLYAVNEVtDGAVSAFRVASDgg 81
Cdd:COG3391   24 AVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSG-SGRVSVIDLATG-- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  82 ltALGSRPTGGAEPCHLAVAPNGRHLFVANYGGGSVAVFplDGQGMPEERTDLVrheghGLDPerqqtahtHMVAPGREG 161
Cdd:COG3391  101 --KVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVI--DTATGKVVATIPV-----GAGP--------HGIAVDPDG 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517413483 162 WPLFVVDLGTD--SVYLYEFDAATGRLAPRacrvpTAAGTGPRHVARHPDGRRCWLVGELDGSVVTY 226
Cdd:COG3391  164 KRLYVANSGSNtvSVIVSVIDTATGKVVAT-----IPVGGGPVGVAVSPDGRRLYVANRGSNTSNGG 225
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
149-326 1.30e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.00  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 149 TAHTHMVAPGREGWPLFVVDLGTDSVYLYEFDAATGRLAPRACRVPTAAGTGPRHVARHPDGRRCWLVGELDGSVVTYEF 228
Cdd:COG3391   18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 229 TTegalrqrGRVSASERPGhVQPSEIAVGPGGRFLYVANRGVGTIAVFALDGELPVRVAEVdsgGEWPRHFALVGPN--L 306
Cdd:COG3391   98 AT-------GKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPV---GAGPHGIAVDPDGkrL 166

                        170       180
                 ....*....|....*....|..
gi 517413483 307 YVADERADLIAVF--RVDPVTG 326
Cdd:COG3391  167 YVANSGSNTVSVIvsVIDTATG 188
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 98-322 2.77e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 44.97  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  98 LAVAPNGRHLFVANYGGGSVAVFPLDGQgmpeertdLVRHEGH-GLDPERQQTAHTHMVAPGREgwpLFVVDLGTDSVYL 176
Cdd:cd14963   13 MGVAVSDGRIYVADTNNHRVQVFDYEGK--------FKKSFGGpGTGPGEFKYPYGIAVDSDGN---IYVADLYNGRIQV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 177 YEFDAA-TGRLAPRACRVpTAAGTGPRHVArhpDGRrcWLVGELDGSVVTYeFTTEGA-LRQRGRVSAseRPGHVQ-PSE 253
Cdd:cd14963   82 FDPDGKfLKYFPEKKDRV-KLISPAGLAID---DGK--LYVSDVKKHKVIV-FDLEGKlLLEFGKPGS--EPGELSyPNG 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517413483 254 IAVGPGGRfLYVANRGVGTIAVFALDGELpvrVAEVDSGGEWPRHFAL-----VGP--NLYVADERADLIAVFRVD 322
Cdd:cd14963  153 IAVDEDGN-IYVADSGNGRIQVFDKNGKF---IKELNGSPDGKSGFVNprgiaVDPdgNLYVVDNLSHRVYVFDEQ 224
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 164-319 5.49e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 44.20  E-value: 5.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 164 LFVVDLGTDSVYLyeFDAaTGRLAPRACRVPTAAGTG--PRHVARHPDGRrcWLVGELDGSVVTyEFTTEGALRQRGRVS 241
Cdd:cd14956   26 VYVADARNGRIQV--FDK-DGTFLRRFGTTGDGPGQFgrPRGLAVDKDGW--LYVADYWGDRIQ-VFTLTGELQTIGGSS 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 242 ASERPGHVQPSEIAVGPGGRfLYVANRGVGTIAVFALDGELpvrVAEVDSGGEWPRHF-----ALVGP--NLYVADERAD 314
Cdd:cd14956  100 GSGPGQFNAPRGVAVDADGN-LYVADFGNQRIQKFDPDGSF---LRQWGGTGIEPGSFnyprgVAVDPdgTLYVADTYND 175


                 ....*
gi 517413483 315 LIAVF 319
Cdd:cd14956  176 RIQVF 180
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 82-280 3.49e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 41.88  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  82 LTALGSRPTG---GAEPCHLAVAPNGRhLFVANYGGGSVAVFPLDGqgmpEERTdLVRHEGHGldpERQQTAHTHMV--A 156
Cdd:cd14956   46 LRRFGTTGDGpgqFGRPRGLAVDKDGW-LYVADYWGDRIQVFTLTG----ELQT-IGGSSGSG---PGQFNAPRGVAvdA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 157 PGRegwpLFVVDLGTDSVylYEFDAATGRLapRAC-RVPTAAG--TGPRHVARHPDGRRcWLVGELDGSVVTyeFTTEGA 233
Cdd:cd14956  117 DGN----LYVADFGNQRI--QKFDPDGSFL--RQWgGTGIEPGsfNYPRGVAVDPDGTL-YVADTYNDRIQV--FDNDGA 185

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 517413483 234 -LRQRGRVSASerPGHV-QPSEIAVGPGGRfLYVANRGVGTIAVFALDG 280
Cdd:cd14956  186 fLRKWGGRGTG--PGQFnYPYGIAIDPDGN-VFVADFGNNRIQKFTADG 231
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 251-310 3.99e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 41.42  E-value: 3.99e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517413483 251 PSEIAVGPGGRFLYVANRGVGTIAVFALDGELPVRVAEVDSG-GEW--PRHFALVGP-NLYVAD 310
Cdd:cd14962  102 PTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRGSGpGEFnlPTDLAVDRDgNLYVTD 165
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
88-329 4.78e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 4.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  88 RPTGGAEPCHLAVAPNGRhLFVANYGGGSVAVF-PLDGQgmpeerTDLVRHEGHGLDPerqqtahtHMVAPGREGwPLFV 166
Cdd:COG4257   54 PLGGGSGPHGIAVDPDGN-LWFTDNGNNRIGRIdPKTGE------ITTFALPGGGSNP--------HGIAFDPDG-NLWF 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 167 VDLGTDSVylYEFDAATGRLapRACRVPTAAGtGPRHVARHPDGrRCWLVGELDGSVVTYEFTTegalrqrGRVSASERP 246
Cdd:COG4257  118 TDQGGNRI--GRLDPATGEV--TEFPLPTGGA-GPYGIAVDPDG-NLWVTDFGANAIGRIDPDT-------GTLTEYALP 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 247 GHVQ-PSEIAVGPGGRfLYVANRGVGTIAVFALDGElpvRVAEVDSGGEWPRHFALV---GPNLYVADERADliAVFRVD 322
Cdd:COG4257  185 TPGAgPRGLAVDPDGN-LWVADTGSGRIGRFDPKTG---TVTEYPLPGGGARPYGVAvdgDGRVWFAESGAN--RIVRFD 258


                 ....*..
gi 517413483 323 PVTGVPV 329
Cdd:COG4257  259 PDTELTE 265
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 86-322 6.05e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 41.11  E-value: 6.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  86 GSRPTGGAEPCHLAVAPNGrHLFVANYGGGSVAVFPLDGQ------GMPEERtdlvrheGHGLDPERqqtahthmVAPGR 159
Cdd:cd14956    6 GSGPGQFKDPRGIAVDADD-NVYVADARNGRIQVFDKDGTflrrfgTTGDGP-------GQFGRPRG--------LAVDK 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 160 EGWpLFVVDLGTDSVYLYEFdaaTGRLAPRACRVPTAAGT--GPRHVARHPDGrrCWLVGELDGSVVTyEFTTEGA-LRQ 236
Cdd:cd14956   70 DGW-LYVADYWGDRIQVFTL---TGELQTIGGSSGSGPGQfnAPRGVAVDADG--NLYVADFGNQRIQ-KFDPDGSfLRQ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 237 RGrvSASERPGH-VQPSEIAVGPGGRfLYVANRGVGTIAVFALDGELPVRVAEVDSG-GE--WPRHFAlVGP--NLYVAD 310
Cdd:cd14956  143 WG--GTGIEPGSfNYPRGVAVDPDGT-LYVADTYNDRIQVFDNDGAFLRKWGGRGTGpGQfnYPYGIA-IDPdgNVFVAD 218

                        250
                 ....*....|..
gi 517413483 311 ERADLIAVFRVD 322
Cdd:cd14956  219 FGNNRIQKFTAD 230
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
182-329 9.26e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.45  E-value: 9.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 182 ATGRLAPRACRVPTAAGTGPRHVARHPDGRRCWLVGELDGSVVTYEFTTEGALRQRGRVSASERPGHVQPSEIAVGPGGR 261
Cdd:COG3391    1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 262 FLYVANRGVGTIAVFALDGELPVRVAEVdsgGEWPRHFALV--GPNLYVADERADLIAVFrvDPVTGVPV 329
Cdd:COG3391   81 RLYVANSGSGRVSVIDLATGKVVATIPV---GGGPRGLAVDpdGGRLYVADSGNGRVSVI--DTATGKVV 145
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 98-319 2.15e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 39.49  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483  98 LAVAPNGRhLFVANYGGGSVAVFpldgqgmpeertDLVRHEGHGLDPErqqtAHTHMVAP----GREGWPLFVVDLGTDS 173
Cdd:cd14962   17 VAADGRGR-IYVADTGRGAVFVF------------DLPNGKVFVIGNA----GPNRFVSPigvaIDANGNLYVSDAELGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 174 VYLYEFDAatgrlapracRVPTAAGTG-----PRHVARHPDGRRCWLVGELDGSVvtYEFTTEGALR----QRGrvsasE 244
Cdd:cd14962   80 VFVFDRDG----------KFLRAIGAGalfkrPTGIAVDPAGKRLYVVDTLAHKV--KVFDLDGRLLfdigKRG-----S 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 245 RPGHV-QPSEIAVGPGGRfLYVANRGVGTIAVFALDGELPVRVAEV-DSGGEW--PRHFALVGP-NLYVADERADLIAVF 319
Cdd:cd14962  143 GPGEFnLPTDLAVDRDGN-LYVTDTMNFRVQIFDADGKFLRSFGERgDGPGSFarPKGIAVDSEgNIYVVDAAFDNVQIF 221
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 250-322 2.62e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 39.22  E-value: 2.62e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517413483 250 QPSEIAVGPGGRfLYVANRGVGTIAVFALDGELPVRVAEVDSGGE---WPRHFAlVGP--NLYVADERADLIAVFRVD 322
Cdd:cd05819    9 NPQGIAVDSSGN-IYVADTGNNRIQVFDPDGNFITSFGSFGSGDGqfnEPAGVA-VDSdgNLYVADTGNHRIQKFDPD 84
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 249-322 3.28e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 38.72  E-value: 3.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517413483 249 VQPSEIAVGPGGRfLYVANRGVGTIAVFALDGELpvrVAEVDSGGEWPRHFALV----GPNLYVADERADLIAVFRVD 322
Cdd:cd14962   57 VSPIGVAIDANGN-LYVSDAELGKVFVFDRDGKF---LRAIGAGALFKRPTGIAvdpaGKRLYVVDTLAHKVKVFDLD 130
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 251-319 3.38e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 38.79  E-value: 3.38e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517413483 251 PSEIAVGPGGRfLYVANRGVGTIAVFALDGELPVrvaEVDSGGEWPRHFAL-----VGP--NLYVADERADLIAVF 319
Cdd:cd14957  114 PYGIAVDSNGN-IYVADTGNHRIQVFTSSGTFSY---SIGSGGTGPGQFNGpqgiaVDSdgNIYVADTGNHRIQVF 185
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 228-319 4.38e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 38.45  E-value: 4.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 228 FTTEGALRQRGRVSASERPGHVQPSEIAVGPGGRfLYVANRGVGTIAVFALDGELpvrVAEVDSGGEWPRHFalVGP--- 304
Cdd:cd05819   81 FDPDGNFLASFGGSGDGDGEFNGPRGIAVDSSGN-IYVADTGNHRIQKFDPDGEF---LTTFGSGGSGPGQF--NGPtgv 154

                         90       100
                 ....*....|....*....|.
gi 517413483 305 ------NLYVADERADLIAVF 319
Cdd:cd05819  155 avdsdgNIYVADTGNHRIQVF 175
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 228-322 5.48e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 38.07  E-value: 5.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517413483 228 FTTEGALRQRGRVSASERPGHVQPSEIAVGPGGRfLYVANRGVGTIAVFALDGELpvrVAEVDSGGEWPRHFAL-----V 302
Cdd:cd05819   34 FDPDGNFITSFGSFGSGDGQFNEPAGVAVDSDGN-LYVADTGNHRIQKFDPDGNF---LASFGGSGDGDGEFNGprgiaV 109

                         90       100
                 ....*....|....*....|..
gi 517413483 303 GP--NLYVADERADLIAVFRVD 322
Cdd:cd05819  110 DSsgNIYVADTGNHRIQKFDPD 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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