|
Name |
Accession |
Description |
Interval |
E-value |
| Lig |
COG0272 |
NAD-dependent DNA ligase [Replication, recombination and repair]; |
3-711 |
0e+00 |
|
NAD-dependent DNA ligase [Replication, recombination and repair];
Pssm-ID: 440042 [Multi-domain] Cd Length: 668 Bit Score: 1054.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 3 PQERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLSLG 82
Cdd:COG0272 6 AKERIEELREELRRHNYRYYVLDAPEISDAEYDALLRELQALEAEHPELITPDSPTQRVGGAPLEGFAKVRHAVPMLSLD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 83 NTYSEEDLIEFDKRVQKGLNGQAYEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGvgr 162
Cdd:COG0272 86 NAFSEEELRDFDRRVRKFLGDEPVEYVCELKIDGLAISLRYENGRLVRAATRGDGTVGEDVTANVRTIRSIPLRLKG--- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 163 grtqnvtpgpdlqsptPMPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCYVY 242
Cdd:COG0272 163 ----------------DDVPEVLEVRGEVYMPKADFEALNEEREEAGEKPFANPRNAAAGSLRQLDPKITAKRPLDFFAY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 243 SFLADETAPgaFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGYTA 322
Cdd:COG0272 227 GLGEVEGLL--PDTQSEALELLKEWGFPVNPERRVCKSIEEVLAYIEEWEEKRHSLPYEIDGVVIKVNDLALQERLGFTS 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 323 KSPRWAIAYKYKAMAASTVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKGGEII 402
Cdd:COG0272 305 RAPRWAIAYKFPAEEATTKLLDIEVQVGRTGALTPVARLEPVFVAGVTVSRATLHNEDEIERKDVRIGDTVVVRKAGDVI 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 403 PKITGVDLTKRTDKSEPIVYPTTCPVCDTPLIRREGErgvaqANFYCPNERGCPPQRQARFEHFIQRRAMNIESLGEGKI 482
Cdd:COG0272 385 PEVVGVVLEKRPGDEKPFVMPTHCPVCGSPLVREEGE-----AALRCTNGLSCPAQLKERLKHFASRKAMDIEGLGEKLI 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 483 ELLIDRGLVETPADLYKLTYDDLLGIEKvfldrnagpeetgkkrivsFREKTVENILTAIEKSKAQSFANVLFALGIRYV 562
Cdd:COG0272 460 EQLVDAGLVKDPADLYRLTKEDLLGLER-------------------MGEKSAQNLLAAIEKSKKTPLARFLFALGIRHV 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 563 GNTTAEKLADYFGSMDAVMAASQEALLAVPDTGPRIAESVVEWFADDYNRAIVEQLRDAGLQfFGEKKVVEREGDTLEGK 642
Cdd:COG0272 521 GETTAKLLARHFGSLDALMAASEEELAAVDGIGPVVAESIVEFFAEPHNRELIERLRAAGVN-MEEEEAEAAADSPLAGK 599
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517451758 643 TFLYTGTFANFTREELENRIEANGGRVLSGISKKLNYLIVGENAGpSKVEKARKLNVPLIGEDEFMAML 711
Cdd:COG0272 600 TFVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTDYVVAGENAG-SKLDKAEELGVPILDEAEFLELL 667
|
|
| ligA |
PRK07956 |
NAD-dependent DNA ligase LigA; Validated |
1-711 |
0e+00 |
|
NAD-dependent DNA ligase LigA; Validated
Pssm-ID: 236137 [Multi-domain] Cd Length: 665 Bit Score: 914.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 1 MIPQERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLS 80
Cdd:PRK07956 3 EEAKKRIEELREELNHHAYAYYVLDAPSISDAEYDRLYRELVALEAEHPELITPDSPTQRVGGAPLDGFEKVRHLVPMLS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 81 LGNTYSEEDLIEFDKRVQKGLNGQAYEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRvkgv 160
Cdd:PRK07956 83 LDNAFSEEELRAFDKRVRKRLPDPPLTYLCELKIDGLAVSLLYENGVLVRAATRGDGTTGEDITANVRTIRSIPLR---- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 161 grgrtqnvtpgpdLQSPtpmPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCY 240
Cdd:PRK07956 159 -------------LHGN---EPERLEVRGEVFMPKADFEALNEERREEGEKPFANPRNAAAGSLRQLDPKITAKRPLSFF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 241 VYSfLADETAPGAFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGY 320
Cdd:PRK07956 223 AYG-VGEVEGGELPDSQSEALEFLKAWGFPVNPYRKLCTSIEEVLAFYEEIEEERHDLPYDIDGVVIKVDDLALQEELGF 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 321 TAKSPRWAIAYKYKAMAASTVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKGGE 400
Cdd:PRK07956 302 TAKAPRWAIAYKFPAEEATTKLLDIEVQVGRTGAVTPVARLEPVEVAGVTVSRATLHNADEIERKDIRIGDTVVVRRAGD 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 401 IIPKITGVDLTKRTDKSEPIVYPTTCPVCDTPLIRREGErgvaqANFYCPNERGCPPQRQARFEHFIQRRAMNIESLGEG 480
Cdd:PRK07956 382 VIPEVVGVVLEKRPGDEREIVMPTHCPVCGSELVRVEGE-----AVLRCTNGLSCPAQLKERLIHFVSRNAMDIDGLGEK 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 481 KIELLIDRGLVETPADLYKLTYDDLLGIEKvfldrnagpeetgkkrivsFREKTVENILTAIEKSKAQSFANVLFALGIR 560
Cdd:PRK07956 457 IIEQLFEKGLIHDPADLFKLTAEDLLGLEG-------------------FGEKSAQNLLDAIEKSKETSLARFLYALGIR 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 561 YVGNTTAEKLADYFGSMDAVMAASQEALLAVPDTGPRIAESVVEWFADDYNRAIVEQLRDAGLQFfgekkVVEREGDTLE 640
Cdd:PRK07956 518 HVGEKAAKALARHFGSLEALRAASEEELAAVEGVGEVVAQSIVEFFAVEENRELIDELLEAGVNM-----EYKGEEVDLA 592
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517451758 641 GKTFLYTGTFANFTREELENRIEANGGRVLSGISKKLNYLIVGENAGpSKVEKARKLNVPLIGEDEFMAML 711
Cdd:PRK07956 593 GKTVVLTGTLEQLSRDEAKEKLEALGAKVSGSVSKKTDLVVAGEAAG-SKLAKAQELGIEVLDEEEFLRLL 662
|
|
| dnlj |
TIGR00575 |
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent ... |
10-707 |
0e+00 |
|
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent DNA ligases. Functions of these proteins include DNA repair, DNA replication, and DNA recombination. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The member of this family from Treponema pallidum differs in having three rather than just one copy of the BRCT (BRCA1 C Terminus) domain (pfam00533) at the C-terminus. It is included in the seed. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273148 [Multi-domain] Cd Length: 652 Bit Score: 787.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 10 LTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLSLGNTYSEED 89
Cdd:TIGR00575 1 LRKLIRHHDYRYYVLDEPSISDAEYDRLYRELQELEEKHPELITPDSPTQRVGAAPLSRFPKVRHSTPMLSLDNAFDEDE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 90 LIEFDKRVQKGLNGQAyEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGvgrgrtqnvt 169
Cdd:TIGR00575 81 LAAFIKRIRRQLGLKV-EYVVEPKIDGLSVSLTYENGVLVRALTRGDGTVGEDVTANVRTIRSIPLRLAG---------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 170 pgpdlqsptPMPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCYVYSFLadET 249
Cdd:TIGR00575 150 ---------DNPPERLEVRGEVFMPKEDFEALNEERREQGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAYGLG--EG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 250 APGAFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGYTAKSPRWAI 329
Cdd:TIGR00575 219 LELPDATQYEALAWLKKWGFPVSPHIRLCDSIEEVLEYYREIEEKRDSLPYEIDGVVVKVDDLALQDELGFTSKAPRWAI 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 330 AYKYKAMAASTVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKGGEIIPKITGVD 409
Cdd:TIGR00575 299 AYKFPAEEAQTKLLDVVVQVGRTGAITPVAKLEPVFVAGTTVSRATLHNEDEIEELDIRIGDTVVVRKAGDVIPKVVRVL 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 410 LTKRTDKSEPIVYPTTCPVCDTPLIRREGErgvaqANFYCPNERgCPPQRQARFEHFIQRRAMNIESLGEGKIELLIDRG 489
Cdd:TIGR00575 379 LEKRTGSERPIRFPTHCPSCGSPLVKIEEE-----AVIRCPNLN-CPAQRVERIKHFASRNAMDIEGLGDKVIEQLFEKK 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 490 LVETPADLYKLTYDDLLGIEKvfldrnagpeetgkkrivsFREKTVENILTAIEKSKAQSFANVLFALGIRYVGNTTAEK 569
Cdd:TIGR00575 453 LVRSVADLYALKKEDLLELEG-------------------FGEKSAQNLLNAIEKSKEKPLARLLFALGIRHVGEVTAKN 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 570 LADYFGSMDAVMAASQEALLAVPDTGPRIAESVVEWFADDYNRAIVEQLRDAGLQFFGEKKVVERE--GDTLEGKTFLYT 647
Cdd:TIGR00575 514 LAKHFGTLDKLKAASLEELLSVEGVGPKVAESIVNFFHDPNNRQLIKKLEELGVEMESLPEKVNAElaGSPLAGKTFVLT 593
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 648 GTFANFTREELENRIEANGGRVLSGISKKLNYLIVGENAGpSKVEKARKLNVPLIGEDEF 707
Cdd:TIGR00575 594 GTLSQMSRDEAKELLENLGGKVASSVSKKTDYVIAGEKAG-SKLAKAQELGIPIINEEEL 652
|
|
| LIGANc |
smart00532 |
Ligase N family; |
4-471 |
0e+00 |
|
Ligase N family;
Pssm-ID: 214709 [Multi-domain] Cd Length: 441 Bit Score: 561.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 4 QERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLSLGN 83
Cdd:smart00532 2 QKEISELRKLLNQHDYRYYVLDAPIISDAEYDRLMRELKELEEKHPELKTPDSPTQRVGGKPLEGFNKVRHPVPMLSLDN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 84 TYSEEDLIEFDKRVQKGLNGQAyEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGvgrg 163
Cdd:smart00532 82 AFDEDELRAFDERIEKALGSPF-AYVVEPKIDGLSVSLLYENGKLVQAATRGDGTVGEDVTQNVKTIRSIPLRLSG---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 164 rtqnvtpgpdlqsptpMPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCYVYS 243
Cdd:smart00532 157 ----------------DVPERLEVRGEVFMPKEDFLALNEELEEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRAFFYG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 244 fLADETAPGAFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGYTAK 323
Cdd:smart00532 221 -LGTGEELFLPKTQSEALKWLKELGFPVSPHTRLCKNADEVIEYYEEWEEKRAELPYEIDGVVVKVDDLALQRELGFTSK 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 324 SPRWAIAYKYKAMAASTVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKGGEIIP 403
Cdd:smart00532 300 APRWAIAYKFPAEEAETKLLDIIVQVGRTGKITPVAELEPVFLAGSTVSRATLHNEDEIEEKDIRIGDTVVVRKAGDVIP 379
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517451758 404 KITGVDLTKRTDKSEPIVYPTTCPVCDTPLIRREGErgvaqANFYCPNErGCPPQRQARFEHFIQRRA 471
Cdd:smart00532 380 KVVGVVKEKRPGDEREIEMPTHCPSCGSELVREEGE-----VDIRCPNP-LCPAQLIERIIHFASRKA 441
|
|
| LIGANc |
cd00114 |
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining ... |
5-335 |
2.13e-140 |
|
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction mechanism. The enzyme reacts with the cofactor to form a phosphoamide-linked AMP with the amino group of a conserved Lysine in the KXDG motif, and subsequently transfers it to the DNA substrate to yield adenylated DNA. This alignment contains members of the NAD+ dependent subfamily only.
Pssm-ID: 238062 [Multi-domain] Cd Length: 307 Bit Score: 413.53 E-value: 2.13e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 5 ERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLSLGNT 84
Cdd:cd00114 1 ERIAELRELLNKHDYRYYVLDEPSVSDAEYDRLYRELRALEEEHPELKTPDSPTQRVGGTPLSGFKKVRHPVPMLSLDNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 85 YSEEDLIEFDKRVQKGLnGQAYEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGvgrgr 164
Cdd:cd00114 81 FDEEELRAFDERIKRFL-GEEPAYVVEPKIDGLSISLRYENGVLVQAATRGDGTTGEDVTENVRTIRSIPLTLAG----- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 165 tqnvtpgpdlqsptpmPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCYVYSF 244
Cdd:cd00114 155 ----------------APETLEVRGEVFMPKADFEALNKEREERGEKPFANPRNAAAGSLRQLDPKITAKRPLRFFIYGL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 245 LadETAPGAFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGYTAKS 324
Cdd:cd00114 219 G--EAEGLGPKTQSEALAFLKEWGFPVSPETRLCKNIEEVLAFYDEIEAKRDSLPYEIDGVVVKVDDLALQRELGFTSKA 296
|
330
....*....|.
gi 517451758 325 PRWAIAYKYKA 335
Cdd:cd00114 297 PRWAIAYKFPA 307
|
|
| DNA_ligase_aden |
pfam01653 |
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining ... |
4-335 |
6.11e-132 |
|
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This domain is the catalytic adenylation domain. The NAD+ group is covalently attached to this domain at the lysine in the KXDG motif of this domain. This enzyme- adenylate intermediate is an important feature of the proposed catalytic mechanism.
Pssm-ID: 396292 [Multi-domain] Cd Length: 318 Bit Score: 392.48 E-value: 6.11e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 4 QERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLSLGN 83
Cdd:pfam01653 4 QQQLEELRELIRKYDYEYYVLDNPSVPDAEYDRLYRELKALEEKHPELITPDSPTQRVGAVPLADFNKVRHLTPMLSLDN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 84 TYSEEDLIEFDKRVQKGLNGQA-YEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGVGr 162
Cdd:pfam01653 84 AFNLDELQAFIERIRRALGNKEkVEYVVEPKIDGLSISLLYENGLLVRAATRGDGTTGEDVTANVKTIRNIPLKLKGDN- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 163 grtqnvtpgpdlqsptpmPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCYVY 242
Cdd:pfam01653 163 ------------------PPERLEVRGEVFMPKEDFEALNEERLEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAY 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 243 SFLADETAPGAFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGYTA 322
Cdd:pfam01653 225 GLGLLEGHELGFDTQYQALAFLKSLGFPVSPLLALCDGIEEVLAYYADWEKKRDSLPYEIDGVVVKVDELALQRELGFTA 304
|
330
....*....|...
gi 517451758 323 KSPRWAIAYKYKA 335
Cdd:pfam01653 305 KAPRWAIAYKFPA 317
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Lig |
COG0272 |
NAD-dependent DNA ligase [Replication, recombination and repair]; |
3-711 |
0e+00 |
|
NAD-dependent DNA ligase [Replication, recombination and repair];
Pssm-ID: 440042 [Multi-domain] Cd Length: 668 Bit Score: 1054.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 3 PQERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLSLG 82
Cdd:COG0272 6 AKERIEELREELRRHNYRYYVLDAPEISDAEYDALLRELQALEAEHPELITPDSPTQRVGGAPLEGFAKVRHAVPMLSLD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 83 NTYSEEDLIEFDKRVQKGLNGQAYEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGvgr 162
Cdd:COG0272 86 NAFSEEELRDFDRRVRKFLGDEPVEYVCELKIDGLAISLRYENGRLVRAATRGDGTVGEDVTANVRTIRSIPLRLKG--- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 163 grtqnvtpgpdlqsptPMPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCYVY 242
Cdd:COG0272 163 ----------------DDVPEVLEVRGEVYMPKADFEALNEEREEAGEKPFANPRNAAAGSLRQLDPKITAKRPLDFFAY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 243 SFLADETAPgaFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGYTA 322
Cdd:COG0272 227 GLGEVEGLL--PDTQSEALELLKEWGFPVNPERRVCKSIEEVLAYIEEWEEKRHSLPYEIDGVVIKVNDLALQERLGFTS 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 323 KSPRWAIAYKYKAMAASTVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKGGEII 402
Cdd:COG0272 305 RAPRWAIAYKFPAEEATTKLLDIEVQVGRTGALTPVARLEPVFVAGVTVSRATLHNEDEIERKDVRIGDTVVVRKAGDVI 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 403 PKITGVDLTKRTDKSEPIVYPTTCPVCDTPLIRREGErgvaqANFYCPNERGCPPQRQARFEHFIQRRAMNIESLGEGKI 482
Cdd:COG0272 385 PEVVGVVLEKRPGDEKPFVMPTHCPVCGSPLVREEGE-----AALRCTNGLSCPAQLKERLKHFASRKAMDIEGLGEKLI 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 483 ELLIDRGLVETPADLYKLTYDDLLGIEKvfldrnagpeetgkkrivsFREKTVENILTAIEKSKAQSFANVLFALGIRYV 562
Cdd:COG0272 460 EQLVDAGLVKDPADLYRLTKEDLLGLER-------------------MGEKSAQNLLAAIEKSKKTPLARFLFALGIRHV 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 563 GNTTAEKLADYFGSMDAVMAASQEALLAVPDTGPRIAESVVEWFADDYNRAIVEQLRDAGLQfFGEKKVVEREGDTLEGK 642
Cdd:COG0272 521 GETTAKLLARHFGSLDALMAASEEELAAVDGIGPVVAESIVEFFAEPHNRELIERLRAAGVN-MEEEEAEAAADSPLAGK 599
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517451758 643 TFLYTGTFANFTREELENRIEANGGRVLSGISKKLNYLIVGENAGpSKVEKARKLNVPLIGEDEFMAML 711
Cdd:COG0272 600 TFVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTDYVVAGENAG-SKLDKAEELGVPILDEAEFLELL 667
|
|
| ligA |
PRK07956 |
NAD-dependent DNA ligase LigA; Validated |
1-711 |
0e+00 |
|
NAD-dependent DNA ligase LigA; Validated
Pssm-ID: 236137 [Multi-domain] Cd Length: 665 Bit Score: 914.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 1 MIPQERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLS 80
Cdd:PRK07956 3 EEAKKRIEELREELNHHAYAYYVLDAPSISDAEYDRLYRELVALEAEHPELITPDSPTQRVGGAPLDGFEKVRHLVPMLS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 81 LGNTYSEEDLIEFDKRVQKGLNGQAYEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRvkgv 160
Cdd:PRK07956 83 LDNAFSEEELRAFDKRVRKRLPDPPLTYLCELKIDGLAVSLLYENGVLVRAATRGDGTTGEDITANVRTIRSIPLR---- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 161 grgrtqnvtpgpdLQSPtpmPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCY 240
Cdd:PRK07956 159 -------------LHGN---EPERLEVRGEVFMPKADFEALNEERREEGEKPFANPRNAAAGSLRQLDPKITAKRPLSFF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 241 VYSfLADETAPGAFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGY 320
Cdd:PRK07956 223 AYG-VGEVEGGELPDSQSEALEFLKAWGFPVNPYRKLCTSIEEVLAFYEEIEEERHDLPYDIDGVVIKVDDLALQEELGF 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 321 TAKSPRWAIAYKYKAMAASTVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKGGE 400
Cdd:PRK07956 302 TAKAPRWAIAYKFPAEEATTKLLDIEVQVGRTGAVTPVARLEPVEVAGVTVSRATLHNADEIERKDIRIGDTVVVRRAGD 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 401 IIPKITGVDLTKRTDKSEPIVYPTTCPVCDTPLIRREGErgvaqANFYCPNERGCPPQRQARFEHFIQRRAMNIESLGEG 480
Cdd:PRK07956 382 VIPEVVGVVLEKRPGDEREIVMPTHCPVCGSELVRVEGE-----AVLRCTNGLSCPAQLKERLIHFVSRNAMDIDGLGEK 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 481 KIELLIDRGLVETPADLYKLTYDDLLGIEKvfldrnagpeetgkkrivsFREKTVENILTAIEKSKAQSFANVLFALGIR 560
Cdd:PRK07956 457 IIEQLFEKGLIHDPADLFKLTAEDLLGLEG-------------------FGEKSAQNLLDAIEKSKETSLARFLYALGIR 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 561 YVGNTTAEKLADYFGSMDAVMAASQEALLAVPDTGPRIAESVVEWFADDYNRAIVEQLRDAGLQFfgekkVVEREGDTLE 640
Cdd:PRK07956 518 HVGEKAAKALARHFGSLEALRAASEEELAAVEGVGEVVAQSIVEFFAVEENRELIDELLEAGVNM-----EYKGEEVDLA 592
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517451758 641 GKTFLYTGTFANFTREELENRIEANGGRVLSGISKKLNYLIVGENAGpSKVEKARKLNVPLIGEDEFMAML 711
Cdd:PRK07956 593 GKTVVLTGTLEQLSRDEAKEKLEALGAKVSGSVSKKTDLVVAGEAAG-SKLAKAQELGIEVLDEEEFLRLL 662
|
|
| dnlj |
TIGR00575 |
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent ... |
10-707 |
0e+00 |
|
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent DNA ligases. Functions of these proteins include DNA repair, DNA replication, and DNA recombination. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The member of this family from Treponema pallidum differs in having three rather than just one copy of the BRCT (BRCA1 C Terminus) domain (pfam00533) at the C-terminus. It is included in the seed. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273148 [Multi-domain] Cd Length: 652 Bit Score: 787.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 10 LTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLSLGNTYSEED 89
Cdd:TIGR00575 1 LRKLIRHHDYRYYVLDEPSISDAEYDRLYRELQELEEKHPELITPDSPTQRVGAAPLSRFPKVRHSTPMLSLDNAFDEDE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 90 LIEFDKRVQKGLNGQAyEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGvgrgrtqnvt 169
Cdd:TIGR00575 81 LAAFIKRIRRQLGLKV-EYVVEPKIDGLSVSLTYENGVLVRALTRGDGTVGEDVTANVRTIRSIPLRLAG---------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 170 pgpdlqsptPMPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCYVYSFLadET 249
Cdd:TIGR00575 150 ---------DNPPERLEVRGEVFMPKEDFEALNEERREQGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAYGLG--EG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 250 APGAFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGYTAKSPRWAI 329
Cdd:TIGR00575 219 LELPDATQYEALAWLKKWGFPVSPHIRLCDSIEEVLEYYREIEEKRDSLPYEIDGVVVKVDDLALQDELGFTSKAPRWAI 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 330 AYKYKAMAASTVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKGGEIIPKITGVD 409
Cdd:TIGR00575 299 AYKFPAEEAQTKLLDVVVQVGRTGAITPVAKLEPVFVAGTTVSRATLHNEDEIEELDIRIGDTVVVRKAGDVIPKVVRVL 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 410 LTKRTDKSEPIVYPTTCPVCDTPLIRREGErgvaqANFYCPNERgCPPQRQARFEHFIQRRAMNIESLGEGKIELLIDRG 489
Cdd:TIGR00575 379 LEKRTGSERPIRFPTHCPSCGSPLVKIEEE-----AVIRCPNLN-CPAQRVERIKHFASRNAMDIEGLGDKVIEQLFEKK 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 490 LVETPADLYKLTYDDLLGIEKvfldrnagpeetgkkrivsFREKTVENILTAIEKSKAQSFANVLFALGIRYVGNTTAEK 569
Cdd:TIGR00575 453 LVRSVADLYALKKEDLLELEG-------------------FGEKSAQNLLNAIEKSKEKPLARLLFALGIRHVGEVTAKN 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 570 LADYFGSMDAVMAASQEALLAVPDTGPRIAESVVEWFADDYNRAIVEQLRDAGLQFFGEKKVVERE--GDTLEGKTFLYT 647
Cdd:TIGR00575 514 LAKHFGTLDKLKAASLEELLSVEGVGPKVAESIVNFFHDPNNRQLIKKLEELGVEMESLPEKVNAElaGSPLAGKTFVLT 593
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 648 GTFANFTREELENRIEANGGRVLSGISKKLNYLIVGENAGpSKVEKARKLNVPLIGEDEF 707
Cdd:TIGR00575 594 GTLSQMSRDEAKELLENLGGKVASSVSKKTDYVIAGEKAG-SKLAKAQELGIPIINEEEL 652
|
|
| ligA |
PRK14351 |
NAD-dependent DNA ligase LigA; Provisional |
5-711 |
0e+00 |
|
NAD-dependent DNA ligase LigA; Provisional
Pssm-ID: 184640 [Multi-domain] Cd Length: 689 Bit Score: 579.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 5 ERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYpEYRQPDSPTARVGGTISKEFATVYHRFPMLSLGNT 84
Cdd:PRK14351 34 EQAEQLREAIREHDHRYYVEADPVIADRAYDALFARLQALEDAF-DLDTENSPTRRVGGEPLDELETVEHVAPMLSIDQS 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 85 YSEEDLIEFDKRVQKGLNgqAYEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGvgrgr 164
Cdd:PRK14351 113 GEADDVREFDERVRREVG--AVEYVCEPKFDGLSVEVVYEDGEYQRAATRGDGREGDDVTANVRTIRSVPQKLRG----- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 165 tqnvtpgpdlqsptpMPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCYVYSF 244
Cdd:PRK14351 186 ---------------DYPDFLAVRGEVYMPKDAFQAYNRERIERGEEPFANPRNAAAGTLRQLDPSVVAERPLDIFFFDV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 245 LAdetAPGAFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGYTAKS 324
Cdd:PRK14351 251 LD---ASELFDSHWEELERFPEWGLRVTDRTERVDDIDDAIAYRDRLLAARDDLNYEIDGVVIKVDDRDAREELGATARA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 325 PRWAIAYKYKAMAASTVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKGGEIIPK 404
Cdd:PRK14351 328 PRWAFAYKFPARAEETTIRDIVVQVGRTGRLTPVALLDPVDVGGVTVSRASLHNPAEIEELGVNVGDRVRVKRAGDVIPY 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 405 ITGVdLTKRTDKSepIVYPTTCPVCDTPlIRREGERGvaqanfYCPNERGCPPQRQARFEHFIQRRAMNIESLGEGKIEL 484
Cdd:PRK14351 408 VEEV-VEKDSEGT--FEFPDTCPVCDSA-VERDGPLA------FCTGGLACPAQLERSIEHYASRDALDIEGLGEERVQQ 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 485 LIDRGLVETPADLYKLTYDDLLGIEkvfldrnagpeetgkkrivSFREKTVENILTAIEKSKAQSFANVLFALGIRYVGN 564
Cdd:PRK14351 478 LVDAGLVESLADLYDLTVADLAELE-------------------GWGETSAENLLAELEASREPPLADFLVALGIPEVGP 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 565 TTAEKLADYFGSMDAVMAASQEALLAVPDTGPRIAESVVEWFADDYNRAIVEQLRDAGLQffgEKKVVEREGDTLEGKTF 644
Cdd:PRK14351 539 TTARNLAREFGTFEAIMDADEEALRAVDDVGPTVAEEIREFFDSERNRAVIDDLLDHGVD---PQPAESEGGDALDGLTF 615
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517451758 645 LYTGTFANFTREELENRIEANGGRVLSGISKKLNYLIVGENAGPSKVEKARKLNVPLIGEDEFMAML 711
Cdd:PRK14351 616 VFTGSLSGYTRSEAQELVEAHGGNATGSVSGNTDYLVVGENPGQSKRDDAEANDVPTLDEEEFEELL 682
|
|
| LIGANc |
smart00532 |
Ligase N family; |
4-471 |
0e+00 |
|
Ligase N family;
Pssm-ID: 214709 [Multi-domain] Cd Length: 441 Bit Score: 561.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 4 QERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLSLGN 83
Cdd:smart00532 2 QKEISELRKLLNQHDYRYYVLDAPIISDAEYDRLMRELKELEEKHPELKTPDSPTQRVGGKPLEGFNKVRHPVPMLSLDN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 84 TYSEEDLIEFDKRVQKGLNGQAyEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGvgrg 163
Cdd:smart00532 82 AFDEDELRAFDERIEKALGSPF-AYVVEPKIDGLSVSLLYENGKLVQAATRGDGTVGEDVTQNVKTIRSIPLRLSG---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 164 rtqnvtpgpdlqsptpMPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCYVYS 243
Cdd:smart00532 157 ----------------DVPERLEVRGEVFMPKEDFLALNEELEEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRAFFYG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 244 fLADETAPGAFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGYTAK 323
Cdd:smart00532 221 -LGTGEELFLPKTQSEALKWLKELGFPVSPHTRLCKNADEVIEYYEEWEEKRAELPYEIDGVVVKVDDLALQRELGFTSK 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 324 SPRWAIAYKYKAMAASTVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKGGEIIP 403
Cdd:smart00532 300 APRWAIAYKFPAEEAETKLLDIIVQVGRTGKITPVAELEPVFLAGSTVSRATLHNEDEIEEKDIRIGDTVVVRKAGDVIP 379
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517451758 404 KITGVDLTKRTDKSEPIVYPTTCPVCDTPLIRREGErgvaqANFYCPNErGCPPQRQARFEHFIQRRA 471
Cdd:smart00532 380 KVVGVVKEKRPGDEREIEMPTHCPSCGSELVREEGE-----VDIRCPNP-LCPAQLIERIIHFASRKA 441
|
|
| LIGANc |
cd00114 |
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining ... |
5-335 |
2.13e-140 |
|
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction mechanism. The enzyme reacts with the cofactor to form a phosphoamide-linked AMP with the amino group of a conserved Lysine in the KXDG motif, and subsequently transfers it to the DNA substrate to yield adenylated DNA. This alignment contains members of the NAD+ dependent subfamily only.
Pssm-ID: 238062 [Multi-domain] Cd Length: 307 Bit Score: 413.53 E-value: 2.13e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 5 ERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLSLGNT 84
Cdd:cd00114 1 ERIAELRELLNKHDYRYYVLDEPSVSDAEYDRLYRELRALEEEHPELKTPDSPTQRVGGTPLSGFKKVRHPVPMLSLDNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 85 YSEEDLIEFDKRVQKGLnGQAYEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGvgrgr 164
Cdd:cd00114 81 FDEEELRAFDERIKRFL-GEEPAYVVEPKIDGLSISLRYENGVLVQAATRGDGTTGEDVTENVRTIRSIPLTLAG----- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 165 tqnvtpgpdlqsptpmPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCYVYSF 244
Cdd:cd00114 155 ----------------APETLEVRGEVFMPKADFEALNKEREERGEKPFANPRNAAAGSLRQLDPKITAKRPLRFFIYGL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 245 LadETAPGAFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGYTAKS 324
Cdd:cd00114 219 G--EAEGLGPKTQSEALAFLKEWGFPVSPETRLCKNIEEVLAFYDEIEAKRDSLPYEIDGVVVKVDDLALQRELGFTSKA 296
|
330
....*....|.
gi 517451758 325 PRWAIAYKYKA 335
Cdd:cd00114 297 PRWAIAYKFPA 307
|
|
| DNA_ligase_aden |
pfam01653 |
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining ... |
4-335 |
6.11e-132 |
|
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This domain is the catalytic adenylation domain. The NAD+ group is covalently attached to this domain at the lysine in the KXDG motif of this domain. This enzyme- adenylate intermediate is an important feature of the proposed catalytic mechanism.
Pssm-ID: 396292 [Multi-domain] Cd Length: 318 Bit Score: 392.48 E-value: 6.11e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 4 QERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLSLGN 83
Cdd:pfam01653 4 QQQLEELRELIRKYDYEYYVLDNPSVPDAEYDRLYRELKALEEKHPELITPDSPTQRVGAVPLADFNKVRHLTPMLSLDN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 84 TYSEEDLIEFDKRVQKGLNGQA-YEYICELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGVGr 162
Cdd:pfam01653 84 AFNLDELQAFIERIRRALGNKEkVEYVVEPKIDGLSISLLYENGLLVRAATRGDGTTGEDVTANVKTIRNIPLKLKGDN- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 163 grtqnvtpgpdlqsptpmPPALFEVRGEGFLPLAEFERINKEREDIGEPLLANPRNAASGTFKQQDSSAVAKRRLDCYVY 242
Cdd:pfam01653 163 ------------------PPERLEVRGEVFMPKEDFEALNEERLEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAY 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 243 SFLADETAPGAFQTHEESLIAMHQWGFNVSQSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQRELGYTA 322
Cdd:pfam01653 225 GLGLLEGHELGFDTQYQALAFLKSLGFPVSPLLALCDGIEEVLAYYADWEKKRDSLPYEIDGVVVKVDELALQRELGFTA 304
|
330
....*....|...
gi 517451758 323 KSPRWAIAYKYKA 335
Cdd:pfam01653 305 KAPRWAIAYKFPA 317
|
|
| ligA |
PRK14350 |
NAD-dependent DNA ligase LigA; Provisional |
4-703 |
8.10e-104 |
|
NAD-dependent DNA ligase LigA; Provisional
Pssm-ID: 172826 [Multi-domain] Cd Length: 669 Bit Score: 331.79 E-value: 8.10e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 4 QERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISKEFATVYHRFPMLSLGN 83
Cdd:PRK14350 6 QDEILDLKKLIRKWDKEYYVDSSPSVEDFTYDKALLRLQELESKYPEYKTLDSPTLKFGSDLLNDFKEVEHSFPILSLDK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 84 TYSEEDLIEF-DKRVQKGLNGQAYEYI-CELKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKgvg 161
Cdd:PRK14350 86 VYDLKLLKLWiEKMDLENSNLGFDFGIsVEPKIDGCSIVLYYKDGILEKALTRGDGRFGNDVTENVRTIRNVPLFID--- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 162 rGRTQNVtpgpdlqsptpmppalfeVRGEGFLPLAEFERINKEREDigePLLaNPRNAASGTFKQQDSSAVAKRRLDCYV 241
Cdd:PRK14350 163 -EKVELV------------------LRGEIYITKENFLKINKTLEK---PYT-NARNLASGILRRIDSREVANFPLDIFV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 242 YSFLadeTAPGAFQTHEESLIAMHQWGFNVS---QSWQKCVDIQAVMQYIDQWEQKRFDLPLGTDGIVIKVNRYDQQREL 318
Cdd:PRK14350 220 YDIL---YSSLELKTNHDAFDKLKKFGFKVNpfcRFFDGKNSIEEILNYVKDIEKKRNSFEYEIDGVVLKVSDFALREIL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 319 GYTAKSPRWAIAYKYKAMAASTVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKG 398
Cdd:PRK14350 297 GYTSHHPKWSMAYKFESLSGFSKVNDIVVQVGRSGKITPVANIEKVFVAGAFITNASLHNQDYIDSIGLNVGDVVKISRR 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 399 GEIIPKITGVdLTKRTDKSEPIvyPTTCPVCDTPLIrREGergvaqANFYCPNeRGCPPQRQARFEHFIQRRAMNIESLG 478
Cdd:PRK14350 377 GDVIPAVELV-IEKLSVGFFKI--PDNCPSCKTALI-KEG------AHLFCVN-NHCPSVIVERIKYFCSKKCMNIVGLS 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 479 EGKIELLIDRGLVETPADLYKLTYDDLLGIEkvfldrnagpeetgkkrivSFREKTVENILTAIEKSKAQSFANVLFALG 558
Cdd:PRK14350 446 DKTIEFLFEKKFISSEIDLYTFNFDRLINLK-------------------GFKDKRINNLKRSIEASKKRPFSKLLLSMG 506
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 559 IRYVG-NTTAEKLADYFGSMDAVMAASQE------ALLAVPDTGPRIAESVVEWFADDYNRAIVEQLRDAGLQFFGEKKV 631
Cdd:PRK14350 507 IKDLGeNTILLLINNNLNSFDKISTLCQDrefalsKLLKIKGIGEKIALNIIEAFNDKIILDKFNFFKNLGFKMEEDSIN 586
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517451758 632 VEREGDTLEGKTFLYTGTFANFTREELENRIEANGGRVLSGISKKLNYLIVGENAGpSKVEKARKLNVPLIG 703
Cdd:PRK14350 587 IDVENSFLFGKKFCITGSFNGYSRSVLIDKLTKKGAIFNTCVTKYLDFLLVGEKAG-LKLKKANNLGIKIMS 657
|
|
| ligB |
PRK08097 |
NAD-dependent DNA ligase LigB; |
4-627 |
1.55e-38 |
|
NAD-dependent DNA ligase LigB;
Pssm-ID: 236150 [Multi-domain] Cd Length: 562 Bit Score: 150.84 E-value: 1.55e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 4 QERIAELTDLLHYYNHQYYQNSTSEVDDFTFDKLLTELTELEIQYPEYRQPDSPTARVGGTISkefatvyHRFPMLSLGN 83
Cdd:PRK08097 31 QEEIAALQQQLAQWDDAYWRQGKSEVDDEVYDQLRARLTQWQRCFGGPEPRDVPLPPLNGKVL-------HPVAHTGVKK 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 84 TYSEEDLIEFDKRvQKGLNGQAyeyicelKFDGVALSLTYENGVFVQGATRGDGVRGDDITNNIRTIRTVPLRVKGvgrg 163
Cdd:PRK08097 104 LADKQALARWMAG-RSDLWVQP-------KVDGVAVTLVYRDGKLVQAISRGNGLKGEDWTAKARLIPAIPQQLPG---- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 164 rtqnvtpgpdlqsptpmPPALFEVRGEGFLPLAEferiNKEREDIGepllANPRNAASGTFKQQDSSAVAkRRLDCYVYS 243
Cdd:PRK08097 172 -----------------ALANLVLQGELFLRREG----HIQQQMGG----INARAKVAGLMMRKDPSPTL-NQIGVFVWA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 244 FladetaPGAFQTHEESLIAMHQWGFNVSQSWQKCVD-IQAVMQYIDQWEQKRfdLPLGTDGIVIKvnrydQQRELG--- 319
Cdd:PRK08097 226 W------PDGPASMPERLAQLATAGFPLTQRYTHPVKnAEEVARWRERWYRAP--LPFVTDGVVVR-----QAKEPPgry 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 320 YTAKSPRWAIAYKYKAMAASTVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKGG 399
Cdd:PRK08097 293 WQPGQGEWAVAWKYPPVQQVAEVRAVQFAVGRTGKITVVLELEPVMLDDKRVSRVNIGSVRRWQQWDIAPGDQVLVSLAG 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 400 EIIPKITGVDLtkRTDKSEPIVYPT-------TCpvcdtplirregergvaqanFYcpNERGCPPQRQARFEHFIQRRAM 472
Cdd:PRK08097 373 QGIPRLDKVVW--RGAERTKPTPPDadrfhslSC--------------------FR--ASPGCQEQFLARLVWLSGKQGL 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 473 NIESLGEGKIELLIDRGLVETPADLYKLTYDDLLGIekvfldrnAGpeetgkkrivsFREKTVENILTAIEKSKAQSFAN 552
Cdd:PRK08097 429 GLDGIGEGTWRALHQTGLFEHLFSWLALTPEQLANT--------PG-----------IGKARAEQLWHQFNLARQQPFSR 489
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517451758 553 VLFALGIRYVGNTTAEKLADyfgSMDAVMAASQEALLAVPDTGPRIAESVVEWFADDYNRAIVEQLRDAGLQFFG 627
Cdd:PRK08097 490 WLKALGIPLPQAALNALDDR---SWQQLLSRSEQQWQQLPGIGEGRARQLIAFLQHPEVKALADWLAAQGITGFE 561
|
|
| DNA_ligase_OB |
pfam03120 |
NAD-dependent DNA ligase OB-fold domain; DNA ligases catalyze the crucial step of joining the ... |
340-417 |
2.07e-38 |
|
NAD-dependent DNA ligase OB-fold domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This family is a small domain found after the adenylation domain pfam01653 in NAD dependent ligases. OB-fold domains generally are involved in nucleic acid binding.
Pssm-ID: 460813 [Multi-domain] Cd Length: 79 Bit Score: 136.73 E-value: 2.07e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517451758 340 TVLKGIRYQVGRTGAVTPVALLKPVLLAGTTVKRASLHNANEIERLGVMLHDTVFVEKGGEIIPKITGVDLTKRTDKS 417
Cdd:pfam03120 2 TKLLDIEFQVGRTGAITPVAVLEPVELAGTTVSRATLHNEDEIKRKDIRIGDTVIVRKAGDVIPEVVGVVLEKRPGDE 79
|
|
| BRCT_DNA_ligase_like |
cd17748 |
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also ... |
639-710 |
5.44e-26 |
|
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also called NAD(+)-dependent polydeoxyribonucleotide synthase, catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.
Pssm-ID: 349379 [Multi-domain] Cd Length: 76 Bit Score: 101.40 E-value: 5.44e-26
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517451758 639 LEGKTFLYTGTFANFTREELENRIEANGGRVLSGISKKLNYLIVGENAGPSK----VEKARKLNVPLIGEDEFMAM 710
Cdd:cd17748 1 LAGKTFVFTGTLSSMSRDEAEELIEALGGKVQSSVSKKTDYLVVGDNAGSKLkkgeELKAKGLGIKIISEEEFLDL 76
|
|
| HHH_2 |
pfam12826 |
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is ... |
553-615 |
5.19e-25 |
|
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.
Pssm-ID: 432812 [Multi-domain] Cd Length: 64 Bit Score: 98.36 E-value: 5.19e-25
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517451758 553 VLFALGIRYVGNTTAEKLADYFGSMDAVMAASQEALLAVPDTGPRIAESVVEWFADDYNRAIV 615
Cdd:pfam12826 2 LLFALGIRHVGETTAKLLARRFGSLDALAEASLEELLEVDDIGPEIAQSIVEFFADPANRELI 64
|
|
| BRCT_RFC1 |
cd17752 |
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed ... |
637-710 |
7.98e-23 |
|
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed activator 1 140 kDa subunit, or A1 140 kDa subunit, or activator 1 large subunit, or activator 1 subunit 1, or replication factor C 140 kDa subunit, or RF-C 140 kDa subunit, or RFC140, is the large subunit of replication factor C (RFC), which is a heteropentameric protein essential for DNA replication and repair. RFC1 can bind single- or double-stranded DNA. It could play a role in DNA transcription regulation as well as DNA replication and/or repair. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.
Pssm-ID: 349383 [Multi-domain] Cd Length: 79 Bit Score: 92.66 E-value: 7.98e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517451758 637 DTLEGKTFLYTGTFANFTREELENRIEANGGRVLSGISKKLNYLIVGENAGPSKVEKARKLNVPLIGEDEFMAM 710
Cdd:cd17752 4 NCLEGLTFVITGVLESLEREEAEDLIKRYGGKVTGSVSKKTSYLVVGRDAGPSKLEKAKELGTKIIDEDGLFDL 77
|
|
| BRCT |
pfam00533 |
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
639-711 |
8.19e-12 |
|
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 61.16 E-value: 8.19e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517451758 639 LEGKTFlYTGTFANFTREELENRIEANGGRVLSGISKKLNYLIVgeNAGPSKVEKARKLNVPLIGEDEFMAML 711
Cdd:pfam00533 6 FSGKTF-VITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIV--EARTKKYLKAKELGIPIVTEEWLLDCI 75
|
|
| BRCT |
smart00292 |
breast cancer carboxy-terminal domain; |
639-707 |
2.19e-10 |
|
breast cancer carboxy-terminal domain;
Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 57.39 E-value: 2.19e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517451758 639 LEGKTFLYTGTFANFTREELENRIEANGGRVLSGISKKLN-YLIVGENAGPS-KVEKARKLNVPLIGEDEF 707
Cdd:smart00292 4 FKGKTFYITGSFDKEERDELKELIEALGGKVTSSLSSKTTtHVIVGSPEGGKlELLKAIALGIPIVKEEWL 74
|
|
| BRCT_PARP1 |
cd17747 |
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2. ... |
639-705 |
1.20e-07 |
|
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2.30), also termed ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1), or NAD(+) ADP-ribosyltransferase 1 (ADPRT 1), or poly[ADP-ribose] synthase 1, is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism.
Pssm-ID: 349378 [Multi-domain] Cd Length: 76 Bit Score: 49.45 E-value: 1.20e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 639 LEGKTFLYTGTFaNFTREELENRIEANGGRVLSGISKKLNYLIVGE---NAGPSKVEKARKLNVPLIGED 705
Cdd:cd17747 1 LTGMKFALIGKL-SKSKDELKKLIEKLGGKVASKVTKKVTLCISTKaevEKMSKKMKEAKEAGVPVVSED 69
|
|
| DNA_ligase_ZBD |
pfam03119 |
NAD-dependent DNA ligase C4 zinc finger domain; DNA ligases catalyze the crucial step of ... |
425-456 |
1.58e-06 |
|
NAD-dependent DNA ligase C4 zinc finger domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This family is a small zinc binding motif that is presumably DNA binding. IT is found only in NAD dependent DNA ligases.
Pssm-ID: 460812 [Multi-domain] Cd Length: 26 Bit Score: 44.73 E-value: 1.58e-06
10 20 30
....*....|....*....|....*....|..
gi 517451758 425 TCPVCDTPLIRREGErgvaqANFYCPNeRGCP 456
Cdd:pfam03119 1 HCPVCGSPLVREEGE-----AALRCTN-LSCP 26
|
|
| MUS81 |
COG1948 |
ERCC4-type crossover junction endonuclease [Replication, recombination and repair]; |
520-604 |
1.59e-06 |
|
ERCC4-type crossover junction endonuclease [Replication, recombination and repair];
Pssm-ID: 441551 [Multi-domain] Cd Length: 214 Bit Score: 49.40 E-value: 1.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 520 EETGKKRIVSFR-EKTVENILTAIEkSKAQSFANVlfalgiryvGNTTAEKLADYFGSMDAVMAASQEALLAVPDTGPRI 598
Cdd:COG1948 130 EQEEEKREVSLHgKKKPKTLREQQL-YVVESLPGI---------GPKLARRLLEHFGSVEAVFNASEEELMKVEGIGEKT 199
|
....*.
gi 517451758 599 AESVVE 604
Cdd:COG1948 200 AERIRE 205
|
|
| BRCT |
cd00027 |
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ... |
643-705 |
1.90e-06 |
|
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.
Pssm-ID: 349339 [Multi-domain] Cd Length: 68 Bit Score: 45.82 E-value: 1.90e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517451758 643 TFLYTGtFANFTREELENRIEANGGRVLSGISKKLNYLIVGENAGPSKVEKARKLNVPLIGED 705
Cdd:cd00027 2 VICFSG-LDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPE 63
|
|
| PRK06195 |
PRK06195 |
DNA polymerase III subunit epsilon; Validated |
629-710 |
4.18e-06 |
|
DNA polymerase III subunit epsilon; Validated
Pssm-ID: 235735 [Multi-domain] Cd Length: 309 Bit Score: 49.39 E-value: 4.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 629 KKVVEREGDT-LEGKTFLYTGTFANFTREELENRIEANGGRVLSGISKKLNYLIVG--------ENAGPSKVEKARKL-- 697
Cdd:PRK06195 210 KKIIESFGFTaFKEEVVVFTGGLASMTRDEAMILVRRLGGTVGSSVTKKTTYLVTNtkdiedlnREEMSNKLKKAIDLkk 289
|
90
....*....|....*.
gi 517451758 698 ---NVPLIGEDEFMAM 710
Cdd:PRK06195 290 kgqNIKFLNEEEFLQK 305
|
|
| PRK06063 |
PRK06063 |
DEDDh family exonuclease; |
654-711 |
2.83e-05 |
|
DEDDh family exonuclease;
Pssm-ID: 180377 [Multi-domain] Cd Length: 313 Bit Score: 46.62 E-value: 2.83e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 517451758 654 TREELENRIEANGGRVLSGISKKLNYLIVGE-NAGPSKVEKARKLNVPLIGEDEFMAML 711
Cdd:PRK06063 247 THEELVERILHAGLAYSDSVDRDTSLVVCNDpAPEQGKGYHARQLGVPVLDEAAFLELL 305
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
512-604 |
3.63e-05 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 47.18 E-value: 3.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517451758 512 FLDRNAGPEETGKKRIVSFR-EKTVeniLTAIEKSKA--QSFANVlfalgiryvGNTTAEKLADYFGSMDAVMAASQEAL 588
Cdd:PRK13766 682 LLKVIAKREQEEEKREVSVHgEKKA---MTLKEQQEYivESLPDV---------GPVLARNLLEHFGSVEAVMTASEEEL 749
|
90
....*....|....*.
gi 517451758 589 LAVPDTGPRIAESVVE 604
Cdd:PRK13766 750 MEVEGIGEKTAKRIRE 765
|
|
| BRCT_TopBP1_rpt2_like |
cd17731 |
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ... |
655-698 |
8.14e-05 |
|
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.
Pssm-ID: 349363 [Multi-domain] Cd Length: 77 Bit Score: 41.37 E-value: 8.14e-05
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 517451758 655 REELENRIEANGGRVLSGISKKLNYLIVGENAGPsKVEKARKLN 698
Cdd:cd17731 18 RKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQ-KYEFARKWN 60
|
|
| uvrC |
PRK00558 |
excinuclease ABC subunit UvrC; |
544-609 |
1.48e-04 |
|
excinuclease ABC subunit UvrC;
Pssm-ID: 234792 [Multi-domain] Cd Length: 598 Bit Score: 45.11 E-value: 1.48e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517451758 544 KSKAqSFANVLfaLGIRYVGNTTAEKLADYFGSMDAVMAASQEALLAVPDTGPRIAESVVEWFADD 609
Cdd:PRK00558 536 RSKA-RLTSAL--DDIPGIGPKRRKALLKHFGSLKAIKEASVEELAKVPGISKKLAEAIYEALHKK 598
|
|
| uvrC |
PRK14666 |
excinuclease ABC subunit C; Provisional |
562-604 |
2.04e-03 |
|
excinuclease ABC subunit C; Provisional
Pssm-ID: 237782 [Multi-domain] Cd Length: 694 Bit Score: 41.41 E-value: 2.04e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 517451758 562 VGNTTAEKLADYFGSMDAVMAASQEALLAVPDTGPRIAESVVE 604
Cdd:PRK14666 645 IGPATARLLWERFGSLQAMAAAGEEGLAAVPGIGPARAAALHE 687
|
|
| BRCT_p53bp1_rpt1 |
cd17745 |
first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins; p53BP1, ... |
639-671 |
2.61e-03 |
|
first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins; p53BP1, also termed 53BP1, or TP53-binding protein 1 (TP53BP1) , is a double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. TP53BP1 contains two tandem BRCT repeats. This family also includes Schizosaccharomyces pombe Crb2, which is a checkpoint mediator required for the cellular response to DNA damage. This model corresponds to the first BRCT domain.
Pssm-ID: 349376 [Multi-domain] Cd Length: 99 Bit Score: 37.68 E-value: 2.61e-03
10 20 30
....*....|....*....|....*....|....*.
gi 517451758 639 LEGKTFLYTGTFAN---FTREELENRIEANGGRVLS 671
Cdd:cd17745 2 FSGCAFLLTGAEETdkpFDKERLESQIEANGGTVLE 37
|
|
| |
