|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
10-394 |
6.70e-84 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 261.47 E-value: 6.70e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 10 ASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTG 89
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 90 LATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLP----AWGWRGLFFV 165
Cdd:cd17371 83 FAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLFLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 166 GIIPVIFAYLVRKNLDESPEWLAAQKQKRTAKKAekSKLIQLFATPRTAATTAALAIMATVQIaGYNGLMIWLPSMLQQS 245
Cdd:cd17371 163 GALPALLVLFIRRFVKEPPQWQAARAARRHFADR--PSLRELFSPPLLRTTLLASLLATGALG-GYYGITTWLPSYLTGE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 246 QGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGV-LIGGAIVGFFSNGMFAG 324
Cdd:cd17371 240 RGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLiLILGFPLGFFASGPFSG 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 325 YGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAMLTLAKKT 394
Cdd:cd17371 320 MGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-364 |
6.83e-68 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 220.31 E-value: 6.83e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 3 YRSKTVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFA 82
Cdd:TIGR00895 14 YQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 83 IGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGL 162
Cdd:TIGR00895 94 VFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 163 FFVG-IIPVIFAYLVRKNLDESPEWLAAQKQKRTAK------------------------KAEKSKLIQLFaTPRTAATT 217
Cdd:TIGR00895 174 FYVGgIAPLLLLLLLMRFLPESIDFLVSKRPETVRRivnaiapqmqaeaqsalpeqkstqGTKRSVFKALF-QGKTARIT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 218 AALAIMATVQIAGYNGLMIWLPSMLQQSqGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFL 297
Cdd:TIGR00895 253 VLLWLLYFMLLVGVYFLTNWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLV 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517491048 298 YAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFIL 364
Cdd:TIGR00895 332 GSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
8-388 |
1.19e-56 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 189.74 E-value: 1.19e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 8 VAASVIGLTLEGMDIMFISFAMSMIIA--NFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGT 85
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 86 ALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLP----AWGWRG 161
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 162 LFFVGIIPVIFAYLVRKNLdespewlaaqkqkrtakkaekskliqlfatprtaattAALAIMATVQIAGYNGLMIWLPSM 241
Cdd:cd17316 161 LFLIGALPALLALLLRRRT-------------------------------------LLLILLWFFISFGYYGLTTFLPTY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 242 LQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYA--SGSAGVLIGGAIVGFFSN 319
Cdd:cd17316 204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVG 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517491048 320 GMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAML 388
Cdd:cd17316 284 GVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-394 |
8.63e-53 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 180.07 E-value: 8.63e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 2 NYRSKTVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLF 81
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 82 AIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRG 161
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 162 LFFVGIIPVIFAYLVRknldespewlaaqkqkrtakkaekskliqlfatprtaatTAALAIMATVQIAGYNGLMIWLPSM 241
Cdd:COG2271 166 AFLILGLPGLLLALLR---------------------------------------FWLLALAYFLVYFALYGFLTWLPTY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 242 LQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIG--IKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSN 319
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517491048 320 GMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAMLTLAKKT 394
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
13-390 |
1.31e-46 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 165.49 E-value: 1.31e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 13 IGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLAT 92
Cdd:PRK12307 25 LGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLAS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 93 SIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIF 172
Cdd:PRK12307 105 GVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 173 AYLVRKNLDESPEWLAAQ-----KQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGY--NGLmiwLPSMLQQS 245
Cdd:PRK12307 185 VIYIRARAPESKEWEEAKlsgkgKHSQSAWSVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGANWpiFGL---LPTYLAGE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 246 QGLSVSSSALWTIStAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMfaGY 325
Cdd:PRK12307 262 GFDTGVVSNLMTAA-AFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYLLLGACLFGLMATNV--GV 338
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517491048 326 GALISR----YFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAMLTL 390
Cdd:PRK12307 339 GGLVPKflydYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGLGAALTFIVAFWTATILLIIGL 407
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
6-377 |
1.49e-42 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 156.01 E-value: 1.49e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 6 KTVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGT 85
Cdd:PRK03893 20 KAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 86 ALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFV 165
Cdd:PRK03893 100 LACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 166 GIIPVIFAYLVRKNLDESPEWLAAQKQKRTAKK-------------------AEKSKLIQLFATPRTAATTAALAIMA-- 224
Cdd:PRK03893 180 GILPIIFALWLRKNLPEAEDWKEKHAGKAPVRTmvdilyrgehriinilltlAAAAALWFCFAGNLQNAAIVAVLGLLca 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 225 ------TVQIAGYN-----GLMI---------W-----LPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIG 279
Cdd:PRK03893 260 aifisfMVQSSGKRwptgvMLMVvvlfaflysWpiqalLPTYLKTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLG 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 280 IKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVG--FFSNGMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSP 357
Cdd:PRK03893 340 TRKAYVCSLLISQLLIIPVFAIGGANVWVLGLLLFFqqMLGQGISGLLPKLIGGYFDTEQRAAGLGFTYNVGALGGALAP 419
|
410 420
....*....|....*....|
gi 517491048 358 MLVGFILQHYQMSMAMGYLA 377
Cdd:PRK03893 420 ILGALIAQRLDLGTALASLS 439
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-400 |
1.77e-42 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 153.50 E-value: 1.77e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 2 NYRSKTVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLF 81
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 82 AIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRG 161
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 162 LFFV-GIIPVIFAYLVRKNLDESPE--WLAAQKQKRTAKKAEKSKLIQLFATPRTAAttaalaimatvqIAGYNGLMIWL 238
Cdd:COG2223 161 AFLIlGILLLVVAVLAWLFLRDPPAgaAAAAKASLRDQLEALRDPRFWLLSLLYFGT------------FGSFIGFSSWL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 239 PSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFS 318
Cdd:COG2223 229 PPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 319 NGM-FAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHY-QMSMAMGYLAALYCISCLAMLTLAKKTSD 396
Cdd:COG2223 309 LGGgNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
....
gi 517491048 397 GKQH 400
Cdd:COG2223 389 AAAA 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-354 |
3.99e-42 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 151.28 E-value: 3.99e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 3 YRSKTVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFA 82
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 83 IGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGL 162
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 163 FFVGIIPVIFAylvrknldespeWLAAQKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYNGLMIWLPSML 242
Cdd:COG2814 167 FLVNAVLALLA------------LLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 243 QQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMF 322
Cdd:COG2814 235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314
|
330 340 350
....*....|....*....|....*....|..
gi 517491048 323 AGYGALISRYFPVEVRSTAtNTIFNFGRAAGG 354
Cdd:COG2814 315 PLLQALVAELAPPEARGRA-SGLYNSAFFLGG 345
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
17-391 |
7.83e-38 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 140.03 E-value: 7.83e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 17 LEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQ 96
Cdd:cd17365 10 LDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 97 VYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVG-IIPVIFAYL 175
Cdd:cd17365 90 LALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGgVPPLILLPL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 176 VRKNLdespeWLAAqkqkrtakkaekskliqlfatprtaattaalaIMATVQIAGYnGLMIWLPSMLQQsQGLSVSSSAL 255
Cdd:cd17365 170 LRGTL-----LLWV--------------------------------TFFMGLLLVY-LLNSWLPKLMVE-AGYSLSQALT 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 256 WTISTAVGMIAGMLAFGQLIDRIGIK-LAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFP 334
Cdd:cd17365 211 ITLLLNIGGVIGSLLLGWLADRFGPKrVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYP 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 517491048 335 VEVRSTATNTIFNFGRAAGGFSPMLVGFILQ-HYQMSMAMGYLAALYCISCLAMLTLA 391
Cdd:cd17365 291 TEVRATGVGWALGVGRLGAILGPLLGGLLLAaGLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
6-389 |
5.93e-35 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 133.42 E-value: 5.93e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 6 KTVAASVIGLTLEGMDiMFISFAMSMIIAN---FHIDMTKGGFISSITNLGM-----LVGGMVFGIMADKFGRVRVFTYT 77
Cdd:cd17369 2 RVALASLVGTAIEWYD-FFIYGTAAALVFNklfFPAVDPAAGTLAAFATFGVgflarPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 78 IFLFAIGTALTGLATSIEQVYVF--------RFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALI 149
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILapillvllRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 150 SAVV--------LPAWGWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTAKKAekskLIQLFatPRTAATTAALA 221
Cdd:cd17369 161 FLLLsallsdeaFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAP----LVEVL--RRHWRALLLAI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 222 IMATVQIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYgiFLLASATAVFLYAY- 300
Cdd:cd17369 235 GLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVY--LAGALLAALFAFPFf 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 301 ---ASGSAGVLIGGAIVGFFS--NGMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSM--AM 373
Cdd:cd17369 313 wllDTGSTWLIVLAAVVVLGVlhGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWwpVA 392
|
410
....*....|....*.
gi 517491048 374 GYLAALYCISCLAMLT 389
Cdd:cd17369 393 LYLAALAVISLVAALF 408
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-390 |
3.83e-31 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 121.91 E-value: 3.83e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 25 ISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIA 104
Cdd:cd17319 22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 105 GLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFV-GIIPVIFAYLVRKNLdes 183
Cdd:cd17319 102 GVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIeGLLGLLLAVLWWFYL--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 184 pewlaaqkqkrtakkaekSKLIQLFATPRTAattaalaimatvqIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAVG 263
Cdd:cd17319 179 ------------------RQVWGLALGYFGI-------------NYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 264 MIAGMLAFGQLIDRIGI---KLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRST 340
Cdd:cd17319 228 GAIGMILGGRLSDRLLRgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAAT 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 517491048 341 ATNTIFNFGRAAGGFSPMLVGFILQH-YQMSMAMGYLAALYCISCLAMLTL 390
Cdd:cd17319 308 AGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
17-393 |
3.89e-31 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 122.76 E-value: 3.89e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 17 LEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQ 96
Cdd:PRK11551 26 LEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 97 VYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFV-GIIPVIFAYL 175
Cdd:PRK11551 106 LLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVgGVGPLLLVPL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 176 VRKNLDESPEWLAAqkqkRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYNgLMIWLPSMLqQSQGLSVSSSAL 255
Cdd:PRK11551 186 LMRWLPESRAFAQA----AGAGKQRAPVLRALFGEGRATATLLLWISYFFTLIVLYF-LLNWLPSLL-VGQGLSRSQAGL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 256 WTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPV 335
Cdd:PRK11551 260 VQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPT 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 517491048 336 EVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQ-MSMAMGYLAALYCISCLAMLTLAKK 393
Cdd:PRK11551 340 QVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRsTVGVIGASIPVILVAALAALLLVSR 398
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-272 |
7.80e-29 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 114.14 E-value: 7.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 4 RSKTVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAI 83
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 84 GTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLF 163
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 164 FVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYNGLMIWLPSMLQ 243
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260
....*....|....*....|....*....
gi 517491048 244 QSQGLSVSSSALWTISTAVGMIAGMLAFG 272
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLL 280
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
19-388 |
1.89e-26 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 109.18 E-value: 1.89e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 19 GMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVY 98
Cdd:cd17324 12 GTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 99 VFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLF-FVGIIPVIFAYLVR 177
Cdd:cd17324 92 LARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFlAIAVLALLAALLLW 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 178 KNLDESPewlaaqkqkrtAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYNGLMIWLPSMLQQSQGLSVSSSALWT 257
Cdd:cd17324 172 RLLPSLP-----------PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 258 ISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPvEV 337
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 517491048 338 RSTAT---NTIFNFGRAAGGFspmLVGFILQHYQMSMAMGYLAALYCISCLAML 388
Cdd:cd17324 320 RGLASslyLAAYNLGGALGAA---LGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-392 |
5.49e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 108.05 E-value: 5.49e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 13 IGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLAT 92
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 93 SIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFV----GII 168
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVcaalALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 169 PVIFAYLVRKNLDESPEWLAAQKQKRTAKKAEKSKLIQLFatprtaattaALAIMATVQIAGYNGLMIWLPSMLQQSQGL 248
Cdd:cd17325 163 ALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLL----------ALFLAIFVLAFAFGALEPFLPLYAAELGGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 249 SVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGAL 328
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517491048 329 ISRYFPVEVRSTAT---NTIFNFGRAAGgfsPMLVGFILQHYQMSMAMgYLAALYCISCLAMLTLAK 392
Cdd:cd17325 313 LADIVPPEGRGTAMglfNTAFSLGMVLG---PLLGGFLYDAFGFATPF-LAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-357 |
6.97e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.12 E-value: 6.97e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 13 IGLTLEGMDIMFISFAMSMIIA-NFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLA 91
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 92 TSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVI 171
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 172 FAYLVRKNLDESPEwlaaqkQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYNGLMIWLPsMLQQSQGLSVS 251
Cdd:pfam07690 163 LAAVLLLLPRPPPE------SKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 252 SSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASG---SAGVLIGGAIVGFFSNGMFAGYGAL 328
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlsSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*....
gi 517491048 329 ISRYFPVEVRSTATNTIFNFGRAAGGFSP 357
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
56-394 |
1.14e-24 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 104.68 E-value: 1.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 56 VGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQV--------YVFRFIAGLGAGGEYGIGMALVAEAWPKNK 127
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIgiwapiilLLARLLQGLSVGGEYGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 128 QGRASSYVSIGAQFGVIIAALISAVV--------LPAWGWRGLFFVGIIPVIFAYLVRKNLDESPewlaAQKQKRTAKKA 199
Cdd:cd17367 135 RGFYSSFQYVTLIGGQLLALGVLLVLqhtlgedqMAAWGWRIPFLLGGVLAVVVLWLRRGLEETE----SFEAIAESNEA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 200 EKSKLIQLFATPRTAATTAALAIMATVQIAGYNglmIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIG 279
Cdd:cd17367 211 SAGTLRELRRHPRELLLVVGLTAGGTLAFYTWT---TYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIG 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 280 IK---LAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALIS-RYFPVEVRSTATNTIFNFGRAA-GG 354
Cdd:cd17367 288 RRpllLFFGIGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINAVVKaELFPTHVRALGVGLPYALAVAIfGG 367
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 517491048 355 FSPMLVGFILQHYQMSMAMGYLAALYCISCLAMLTLAKKT 394
Cdd:cd17367 368 TAPYVALWLKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
12-324 |
4.16e-24 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 102.64 E-value: 4.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 12 VIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLA 91
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 92 TSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVI 171
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 172 FAYLvrknldespewlaaqkqkrtakkaekskLIQLFATPRTAATTAAlaimatvqiAGYNGLMIWLPSMLQQSQGLSVS 251
Cdd:cd17321 162 VALL----------------------------LARTFSGAVLAAFLLG---------AALGGLLFLLPLYLQGVLGYSPL 204
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517491048 252 SSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGV--LIGGAIVGFFSNGMFAG 324
Cdd:cd17321 205 QAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVwlLLPGLVLLGLGLGLFAT 279
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-388 |
5.16e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 102.50 E-value: 5.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 12 VIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLA 91
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 92 TSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPA--WGWRGLFFVGIIP 169
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 170 VIFAYLVRKNLDESPEWlaaqKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYNGLMIWLPSMLQQSQGLS 249
Cdd:cd06174 162 ALLAAILLLLVVPDPPE----SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 250 VSSSALWTISTAVGMIAGMLAFGQLIDR-IGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGAL 328
Cdd:cd06174 238 VAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 329 ISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAML 388
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
8-360 |
2.56e-23 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 100.91 E-value: 2.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 8 VAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKggFISSITNLGML--------VGGMVFGIMADKFGRVRVFTYTIF 79
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSE--FASLLLTFATFgvgffmrpIGAIVLGAYADRIGRKPAMTLTLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 80 LFAIGTALTGLATSIEQ--------VYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISA 151
Cdd:cd17368 79 IMALGTLLIALAPTYATigiaapllVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 152 VV--------LPAWGWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQkqkrtaKKAEKSKLIQLFATPRTAATTAALAIM 223
Cdd:cd17368 159 LLsltltaeaLAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERK------ARPTRRELFALLANNRRIILLGMLLVA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 224 ATVqIAGYNgLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIK---LAYGIFLLASATAVFLYAY 300
Cdd:cd17368 233 GST-VTFYF-TTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRpvlLVITLAALVTLYPVFAWLT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517491048 301 ASGSAGVLIGGAIV-GFFSNGMFAGYGALISRYFPVEVRSTATNTIFNFGRAA-GGFSPMLV 360
Cdd:cd17368 311 AAPSFGRLLLVLLVlSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIfGGFAQFIV 372
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
12-387 |
1.05e-21 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 96.57 E-value: 1.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 12 VIGLTLEGMDIMFISFAMSMIIANFHIDMTK-----------GGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFL 80
Cdd:pfam00083 6 ALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKsvsslaalsvlSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 81 FAIGTALTGLAT---SIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAA---LISAVVL 154
Cdd:pfam00083 86 FVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYifgLGLNKTS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 155 PAWGWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTAKK---------------------------AEKSKLIQL 207
Cdd:pfam00083 166 NSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREvlaklrgvpdvdreldeikdsleagqeAEKASWKEL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 208 FATPRTAATTAALAIMATV-QIAGYNGLMIWLPSMLQQsqgLSVSSSALWTIST-AVGMIAGMLAFgQLIDRIGIK--LA 283
Cdd:pfam00083 246 FSTKTRRQRLLIGVMLQIFqQLTGINAIFYYSTTIFEN---LGLSDSFLVTIIVgVVNFVFTFIAI-FLVDRFGRRplLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 284 YGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGA--------LISRYFPVEVRSTATntifNFGRAAGGF 355
Cdd:pfam00083 322 LGAAGMAICFVILGIVALLGVSKSDWAGIVAIVFIALFIAFFAMgwgpvpwvIVSELFPLSVRSKAM----ALATAANWL 397
|
410 420 430
....*....|....*....|....*....|..
gi 517491048 356 SPMLVGFILQHYQMSMAMGYLAALYCISCLAM 387
Cdd:pfam00083 398 ANFLIGFLFPIITDAIGLGYTFFIFAGLLVLF 429
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
17-386 |
8.32e-21 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 93.02 E-value: 8.32e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 17 LEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQ 96
Cdd:cd17359 12 LFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 97 VYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAW--------GWRGLFFVGII 168
Cdd:cd17359 92 FIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGgadwlgaeGWRWMLGLEAI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 169 PVIFAYLVRKNLDESPEWLAAQKQKrtakkaekskliqlfatprtaATTAALAIMATVQIAGYNGLMIWLPSMLQQSqGL 248
Cdd:cd17359 172 PAILFLLGMLFIPESPRWLVSKGKP---------------------ILIIGIGLAIFQQFVGINVIFYYGPEIFQNA-GF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 249 SVSSSALWTISTAVGMIAGMLAFGQLIDRIG---------IKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSN 319
Cdd:cd17359 230 SENAALLQTIGIGVVNVIFTIIAILLVDKVGrkpllligsIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAM 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517491048 320 GMFAGYGALISRYFPVEVR------STATNTIFNFgrAAGGFSPMLVGfilqhyqmSMAMGYLAALYCISCLA 386
Cdd:cd17359 310 SWGPVTWVLLSEIFPNRIRglamgiAVFFLWIANF--LVSLTFPILLA--------AFGLAFTFLIFAVICVL 372
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
56-394 |
1.36e-20 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 92.42 E-value: 1.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 56 VGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQV--------YVFRFIAGLGAGGEYGIGMALVAEAWPKNK 127
Cdd:cd17366 55 LGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTYATIgvwapillLLARMVQGFSTGGEYGGAATFVAEYAPDRK 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 128 QGRASSYVSIGAQFGVIIAALISAVV--------LPAWGWRGLFFVGIIPVIFAYLVRKNLdespewlaaqkqkrtakka 199
Cdd:cd17366 135 RGFLGSWLEFGTLAGFILGAGLVTLLtlllteaqMLDWGWRIPFLIAAPLGLVGLYLRRPL------------------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 200 ekskliqlfatprtaatTAALAIMATVQIAGYNgLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIG 279
Cdd:cd17366 196 -----------------LICIGLVLVFNVTNYM-LLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 280 IK---LAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTATNTIFNFGRA-AGGF 355
Cdd:cd17366 258 RKpvyAAGLAGLLVLAVPAFLLMNSGSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSlFGGT 337
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 517491048 356 SPMLVGFILQHYQMSMAMG-YLAALYCISCLAMLTLAKKT 394
Cdd:cd17366 338 TPLVASWLVSATGNPLMPAyYLMVAAVVGLVAVLFLTETA 377
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
12-354 |
2.79e-20 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 91.48 E-value: 2.79e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 12 VIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLA 91
Cdd:cd17503 2 LLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 92 TSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVI 171
Cdd:cd17503 82 PNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 172 FAYLVRKNLDespewlaaqkqkrtakkaeksklIQLFATPRTAATTAALAIMAtvqiAGYNGLMIWLPSMLQQSQGLSVS 251
Cdd:cd17503 162 LALLLAPLLD-----------------------LRLFKDRNFTLGLLLSFLLG----LGLFGAMFLLPLYLQNVLGYSAF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 252 SSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGV--------LIGGAIVGFFSNGMFA 323
Cdd:cd17503 215 ESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLwliilplfIRGLGMGLVFMPLNTL 294
|
330 340 350
....*....|....*....|....*....|.
gi 517491048 324 GYGALisryfPVEVRSTATnTIFNFGRAAGG 354
Cdd:cd17503 295 ALNSL-----PPEQIGDAT-ALFNTIRQLGG 319
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
32-395 |
3.67e-20 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 91.45 E-value: 3.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 32 IIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGE 111
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 112 YGIGMALVAEAWPKNKQGRASSY---VSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIFAYLVRKNldespeWLA 188
Cdd:COG0738 114 DVAANPYVAALGPETAASRLNLLhafFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRS------KLP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 189 AQKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYNglmiWLPSMLQQSQGLSVSSSALWTISTAVGMIAGM 268
Cdd:COG0738 188 EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGD----WLPLYLKDVLGLSEATAALGLSLFWGGMTIGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 269 LAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEvRSTATNTIFNF 348
Cdd:COG0738 264 FLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIM 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 517491048 349 GRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAMLTLAKKTS 395
Cdd:COG0738 343 GIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
25-394 |
4.90e-20 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 91.09 E-value: 4.90e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 25 ISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIA 104
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 105 GLGAGGEYGIGMALVAEAWPKnKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIFAYLVrknldesp 184
Cdd:COG2807 117 GAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLL-------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 185 eWLAAQKQKRTAKKAEKSKliQLFATPRTAATTAALAIMATVQIAGYNGLMIWLPSMLQQsQGLSVSSSALWTISTAVGM 264
Cdd:COG2807 188 -WLPLLRRRPAAAAAAPAA--ASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 265 IAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFP-VEVRSTATN 343
Cdd:COG2807 264 IPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSG 343
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 517491048 344 TIFNFGRAAGGFSPMLVGFILQH---YQMSMAMgyLAALYCISCLAMLTLAKKT 394
Cdd:COG2807 344 MAQSVGYLLAALGPLLVGALHDAtgsWTAALLL--LAALAVLMLVAGLLAGRPY 395
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
7-342 |
5.12e-18 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 85.32 E-value: 5.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 7 TVAASVIGLTLeGMDIMFISFAMSMI----IANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFA 82
Cdd:cd17358 4 TFVANLGSFSF-GIAVGWSSPALPSLmsdnSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 83 IGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVlpawGWRGL 162
Cdd:cd17358 83 LGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----PWRTL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 163 FFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTAKKA-----------------------------EKSKLIQLFATPRT 213
Cdd:cd17358 159 ALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSlqflrgkdadiskeaaeiqeelaelekeaKESSFSDLFQRKYL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 214 AATTAALAIMATVQIAGYNGLMIWLPSMLQQSQglSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKL-----AYGIFL 288
Cdd:cd17358 239 KPLVIGLGLMLFQQLSGINAVIFYASSIFDEAG--SGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPlllvsAIGMGI 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517491048 289 LASATAVFLY----AYASGSAGVLIGGAIVGF---FSNGMFAGYGALISRYFPVEVRSTAT 342
Cdd:cd17358 317 GLLALGLYFYlqehGALLSSVSWLPLVGLVIYiisFSIGLGPLPWVIMSEIFPAKIKGLAG 377
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
56-375 |
6.64e-18 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 85.53 E-value: 6.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 56 VGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVF--------RFIAGLGAGGEYGIGMALVAEAWPKNK 127
Cdd:PRK10642 72 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWapillllcKMAQGFSVGGEYTGASIFVAEYSPDRK 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 128 QGRASSYVSIGAQFGVIIAA----LISAVVLPA----WGWRGLFFVGIIPVIFAYLVRKNLDESPEWL-----AAQKQKR 194
Cdd:PRK10642 152 RGFMGSWLDFGSIAGFVLGAgvvvLISTIVGEAnfldWGWRIPFFIALPLGIIGLYLRHALEETPAFQqhvdkLEQGDRE 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 195 TAKKAEKSKLIQLFatPRTAATTAALAIMATVQIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQL 274
Cdd:PRK10642 232 GLQDGPKVSFKEIA--TKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLL 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 275 IDRIGIKlaygIFLLASATAVFLYAY------ASGSAGVLIGGAIVGFFSNGMFAGYGA-LISRYFPVEVRSTATNTIFN 347
Cdd:PRK10642 310 SDRFGRR----PFVILGSVALFVLAIpafiliNSNVIGLIFAGLLMLAVILNCFTGVMAsTLPAMFPTHIRYSALAAAFN 385
|
330 340
....*....|....*....|....*...
gi 517491048 348 FGRAAGGFSPMLVGFILQHYQMSMAMGY 375
Cdd:PRK10642 386 ISVLVAGLTPTLAAWLVESTQNLMMPAY 413
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
13-354 |
1.03e-17 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 83.38 E-value: 1.03e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 13 IGLTLEGMDIMFISFAMSMIIANFHiDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLAT 92
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 93 SIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIF 172
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 173 AYLvrknldespewlaaqkqkrtakkaekskLIQLFATPRTAATTAAlaimatvqiAGYNGLMIWLPSMLQQSQGLSVSS 252
Cdd:cd17502 162 ALA----------------------------LLRTILLSSIFGFLFG---------GALFGLIYYLPLYFQLVLGDSATK 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 253 SALWTISTAVGMIAGMLAFGQLIDRIGI--KLAYGIFLLASATAVFLYAYASGSAGVLIGG--AIVGFFSNGMFAGYGAL 328
Cdd:cd17502 205 SGVRLLPLIIGLVIGSIISGALISKTGRykPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGylILLGLGLGIGFQQPLVA 284
|
330 340
....*....|....*....|....*.
gi 517491048 329 ISRYFPVEVRSTATnTIFNFGRAAGG 354
Cdd:cd17502 285 VQNAVPPADVGVAT-ATNTFFRSLGG 309
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
28-389 |
1.74e-17 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 83.39 E-value: 1.74e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 28 AMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLG 107
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 108 AGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLF-FVGIIPVIFAYLVRKNLDESPEw 186
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFvFLALLGLLLLLLVLLFLPETLP- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 187 laaqkqkrtaKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYNGLMIWL---PSMLQQSQGLSVSSSALWTISTAVG 263
Cdd:cd17320 180 ----------EEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLaaaPFIYIEQLGLSPAQFGLLFALNAIA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 264 MIAGMLAFGQLIDRIGIK--LAYGIFLLASATAVFLYAYASGSAGV--LIGGAIVGFFSNGM-FAGYGALISRYFPvEVR 338
Cdd:cd17320 250 LILGSLLNGRLVRRFGPRrlLRLGLLLLLAAALVLLLAALLGGLSLwpLVAPLFLIFFGFGLiFPNATSLALEPFP-HVA 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 517491048 339 STATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAMLT 389
Cdd:cd17320 329 GTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
10-348 |
2.74e-17 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 82.62 E-value: 2.74e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 10 ASVIGLTLEGMDIMFISFAMSMIIANFHI--DMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTAL 87
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 88 TGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVL--PAWGWRGLFFV 165
Cdd:cd17315 81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSlsPPGWWRLMFAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 166 GIIPVIFAYLVRKNLDESPEWLAAQkqkrtakkaekskLIQLFatprtaattaalaimatVQIAGYNGLMIWLPSMLQQS 245
Cdd:cd17315 161 AAVPALLQLLLMFFLPESRALLVGV-------------GLQLL-----------------QQLTGINAVMYYAPTIFKSA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 246 QGLSvSSSALWTISTAVGMIAGMLAFGqLIDRIGIK-------LAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFS 318
Cdd:cd17315 211 GGGT-ASILASIIVGVVNLLATLVAIR-LVDKVGRRpllligfAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAA 288
|
330 340 350
....*....|....*....|....*....|....*...
gi 517491048 319 NGMFAG--YGALISRYFPVEVR------STATNTIFNF 348
Cdd:cd17315 289 FAMGAGpvPWLLLSEIFPLRIRgkgmaiATLVNWIFNF 326
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
24-386 |
4.07e-17 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 82.22 E-value: 4.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 24 FISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFI 103
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 104 AGLGAGGEYGIGMALVAEAWPKNKqGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIP-VIFAYLVRKNLDE 182
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAGGRR-GLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPgLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 183 SPEWLAAQKQKRTAKKAEKSKLIQLFATPRTAATTAALaimatvqiagYNGLMIWLPSMLQQSQGLSVSSSALWTISTAV 262
Cdd:cd17478 173 KKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWV----------LSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 263 GMIAGMLAfGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAgVLIGGAIVGFFSNGMFAGYGALISRYFPvEVRSTAT 342
Cdd:cd17478 243 GAIGTLIG-GPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIW-SYILLVLAGFLLFASFPVTVVLAQELLP-GNVGLAS 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 517491048 343 NTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLA 386
Cdd:cd17478 320 GLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
36-385 |
1.21e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 80.69 E-value: 1.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 36 FHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIG 115
Cdd:cd17474 29 LGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 116 MALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAvVLPAWGWRGLFFVGIIPVIFAYLVRKNLDESPEwlaAQKQKRT 195
Cdd:cd17474 109 LTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGG-LLAAISWRYPFFLLAALIPVAFLAILFLLPEPK---EKAKSSS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 196 AKKAEKSKLIQLfatprtAATTAALAIMATVQIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLI 275
Cdd:cd17474 185 ATKLRDLKKALR------GRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 276 D-RIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTATnTIFNFGRAAGG 354
Cdd:cd17474 259 KkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTAS-SLYNFVRFLGQ 337
|
330 340 350
....*....|....*....|....*....|..
gi 517491048 355 -FSPMLVGFILQHYQMSMAMGYLAALYCISCL 385
Cdd:cd17474 338 aVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
22-382 |
2.07e-16 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 80.06 E-value: 2.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 22 IMFISFAMS---------MIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLAT 92
Cdd:cd17333 3 ISFFSNGLTdallgilgpSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 93 SIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRAS---SYVSIGAQFGVIIA-ALISAVVLPAWGWRGLFFVGII 168
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNvlhGFFGLGALIGPLIAtSLLTSELSWSWAYLIIGLIYLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 169 PVIFAYLVRKnldespEWLAAQKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYNglmiWLPSMLQQSQGL 248
Cdd:cd17333 163 LAILILLTLF------PELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSS----WVPSYLVEKKHV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 249 SVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGAL 328
Cdd:cd17333 233 SDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSL 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 517491048 329 ISRYFPVEVRSTaTNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCI 382
Cdd:cd17333 313 GISNLPYAKGKG-TSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAI 365
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-391 |
2.70e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 79.92 E-value: 2.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAW 123
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 124 PKNKQGRASSYVSIGAQFGVIIAALISAvVLPAWGWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTAKKAEKSK 203
Cdd:cd17473 118 EGEERAKMLGLQSAAMSLGGVVFLLLGG-ALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPW 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 204 LIQLFatprtaattaaLAIMATVQIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLA 283
Cdd:cd17473 197 KRVLP-----------IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 284 YGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTAT---NTIFNFGRAaggFSPMLV 360
Cdd:cd17473 266 LAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMgivTSAFFLGQF---LSPLVL 342
|
330 340 350
....*....|....*....|....*....|.
gi 517491048 361 GFILQHYQMSMAMGYLAALYCISCLAMLTLA 391
Cdd:cd17473 343 GPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
56-198 |
3.52e-16 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 79.78 E-value: 3.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 56 VGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQV--------YVFRFIAGLGAGGEYGiGMALVA-EAWPKN 126
Cdd:PRK09952 79 LGGVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIgwwapvllVTLRAIQGFAVGGEWG-GAALLAvESAPKN 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 127 KQGRASSYVSIGAQFGVIIA----ALISAVV----LPAWGWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTAKK 198
Cdd:PRK09952 158 KKAFYSSGVQVGYGVGLLLStglvSLISMMTtdeqFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKK 237
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
47-199 |
3.54e-16 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 80.06 E-value: 3.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 47 SSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKN 126
Cdd:TIGR00898 133 QSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKK 212
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517491048 127 KQGRASSYVSIGAQFGVIIAALIsAVVLPawGWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTAKKA 199
Cdd:TIGR00898 213 QRAIVGTLIQVFFSLGLVLLPLV-AYFIP--DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKI 282
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
32-388 |
4.94e-16 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 79.24 E-value: 4.94e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 32 IIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYV-FRFIAGLGAGG 110
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLlWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 111 EYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWR------GLFFVGIIPVIFAYLVRKNLDESP 184
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRtallvlALLALLVLVPVLLLLRRRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 185 EWLAAQKQKR---TAKKAEKSKLIQLFATPRTAATtaalaimatvqiAGYNGLMIWLPSMLqQSQGLSVSSSAlWTIST- 260
Cdd:cd17355 189 RAYDDASPASpgsTLKEALRSASFWLLALAFFLCG------------FAVVGLIVHLVPYL-ADRGISPAAAA-VALALi 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 261 AVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIG-GAIVGFFSNGMFAGYGALISRYFPVEVRS 339
Cdd:cd17355 255 GLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLfAALFGLGWGATVPLTAALAARYFGARSYG 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 517491048 340 TATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAML 388
Cdd:cd17355 335 TLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLV 383
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
28-168 |
5.08e-16 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 78.77 E-value: 5.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 28 AMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLG 107
Cdd:cd17323 21 ALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFF 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517491048 108 AGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGII 168
Cdd:cd17323 101 GSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
44-379 |
1.14e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 77.63 E-value: 1.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAW 123
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 124 PKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIFAYLvrknldespewLAAQKQKRTAKKAEKSK 203
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL-----------LVFLVKDPPPVAAEEAE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 204 LIQLFATPRTAATTAALAIMATVQIAGYNGLMIWLPSMLQQsqgLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLA 283
Cdd:cd17489 183 AGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAE---RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 284 YGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFI 363
Cdd:cd17489 260 IIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV 339
|
330
....*....|....*.
gi 517491048 364 LQHYQMSMAMGYLAAL 379
Cdd:cd17489 340 AELFGYRAMFLLAAVV 355
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
28-391 |
6.24e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 75.69 E-value: 6.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 28 AMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLG 107
Cdd:cd17504 18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 108 aGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIFAY----LVRKNLDES 183
Cdd:cd17504 98 -GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAalvpLIDLRLLRR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 184 PEWLAAQkqkrtakkaekskLIQLFATPRTAattaalaimatvqiagynGLMIWLPSMLQQSQ----GLSVSSSALWTIS 259
Cdd:cd17504 177 RNVLLAN-------------ITALLAGFGMF------------------MVFQLLPQLLQLPTptgfGLGITEAGLLLLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 260 TAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAY-ASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVR 338
Cdd:cd17504 226 GALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRT 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517491048 339 STAT---NTIFNFGraaGGFSPMLVGFILQHYQMSMAM-------GYLAALYCISCLAMLTLA 391
Cdd:cd17504 306 GIATgmnTVLRTIG---SAIGPAIAGAILTTYTVSITSggvptegAYVLAFLIGAALALAALL 365
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
26-367 |
2.53e-14 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 73.95 E-value: 2.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 26 SFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAG 105
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 106 LGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLP-AWGWRGLFFV-GIIPVIFAYLVRKNLDES 183
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAeLYSWHWVFIVpGIIAIIVSLICFLLLRDS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 184 P---------EWLAAQKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYN-GLMIWLPSMLQQSQGLSVSSS 253
Cdd:TIGR00881 175 PqscglppaeEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRtGILDWSPLYLTQEKGFSKEKA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 254 ALWTISTAVGMIAGMLAFGQLIDRI--GIKLAYGIFLLA---SATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGAL 328
Cdd:TIGR00881 255 SWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMAliiVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVI 334
|
330 340 350
....*....|....*....|....*....|....*....
gi 517491048 329 ISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHY 367
Cdd:TIGR00881 335 ASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGF 373
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-176 |
1.24e-13 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 67.67 E-value: 1.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 52 LGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRA 131
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVA 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 517491048 132 SSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIFAYLV 176
Cdd:TIGR00880 89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
10-347 |
6.59e-13 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 69.61 E-value: 6.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 10 ASVIGLTLEGMDIMFISFAMSMIIANF-HIDMTKGG--FISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTA 86
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYIKDDLgEVVLSTGWqeLIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 87 LTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISA--VVLPAwGWRGLFF 164
Cdd:cd17360 81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGafSYLPG-GWRWMLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 165 VGIIPVIFAYLVRKNLDESPEWlaaqkqKRTAKKAEKSKLIQLFAtprtaattaalaimatvQIAGYNGLMIWLPSMLQ- 243
Cdd:cd17360 160 LAAVPAVLQFIGLLFLPESPRW------PSTRRALIVGCGLQAFQ-----------------QFSGINTVMYYSATILQm 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 244 ---QSQGLSVSSSALWTISTAVGMIAGMLafgqLIDRIGIKlaygIFLLASATAVFLyAYASGSAGVLIGGAIV--GFFS 318
Cdd:cd17360 217 agfKDNQNAIWLSLIVAGTNFIFTIVGMY----LIDKFGRR----KLLLISLFGVIV-ALVVLAVWLALVGLILylAFFA 287
|
330 340 350
....*....|....*....|....*....|....*
gi 517491048 319 NGMFAGYGALISRYFPVEVR------STATNTIFN 347
Cdd:cd17360 288 PGMGPVPWTVNSEIYPLWARgtgggcAAAVNWVFN 322
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
44-202 |
1.04e-12 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 69.21 E-value: 1.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLA---TSIEQVYVFRFIAGLGAGGEYGIGMALVA 120
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 121 EAWPKNKQGRASSYVSIGAQFGVIIAALIS--AVVLPAWGWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTAkk 198
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEE-- 209
|
....
gi 517491048 199 AEKS 202
Cdd:cd17357 210 AEKS 213
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
25-390 |
1.12e-12 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 68.84 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 25 ISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIA 104
Cdd:cd17312 22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 105 GLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFV-GIIPVIFAYLVRKNLDES 183
Cdd:cd17312 102 GLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVpGIVGLVVAIILFFFLRDS 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 184 PEWLaaqkqkrtakkaekskliqlfatprtaatTAALAIMATVQIAGYnGLMIWLPSMLQQSQGLSVSSSALWTISTAVG 263
Cdd:cd17312 182 PPYV-----------------------------WVLSLAYAFVYIVRY-ACLDWGPLYLYEVKGYSLIDAGWFSSLYEVG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 264 MIAGMLAFGQLIDRIGIK---LAYGIFLLASATAVFLYAYASGSAGVLIG-GAIVGFFSNGMFAGYGALISRYFPV-EVR 338
Cdd:cd17312 232 GIAGTILAGLLSDKLFGGrraPIAVIYMLLMTLSLALFWFFPHNKLLSIVlLFLIGFFVGGPINLIGGAAAQDIGRkEAA 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 517491048 339 STATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAMLTL 390
Cdd:cd17312 312 GTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
12-187 |
1.74e-12 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 68.80 E-value: 1.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 12 VIGLTL--EGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTG 89
Cdd:cd17438 3 VLGLALmaDGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 90 LATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWG----------- 158
Cdd:cd17438 83 FVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGwgfsmgtnyhf 162
|
170 180 190
....*....|....*....|....*....|.
gi 517491048 159 --WRGLFFVGIIPVIFAYLVRKNLDESPEWL 187
Cdd:cd17438 163 hsWRVFVIICALPCIASIIALKFMPESPRFL 193
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
12-176 |
2.95e-12 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 68.17 E-value: 2.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 12 VIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLA 91
Cdd:TIGR00711 8 MLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 92 TSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVI 171
Cdd:TIGR00711 88 PNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGI 167
|
....*
gi 517491048 172 FAYLV 176
Cdd:TIGR00711 168 IVVVV 172
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
59-388 |
2.78e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 64.49 E-value: 2.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 59 MVFGIMADKFGRVRVFTYT-IFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSI 137
Cdd:cd17370 52 LFSGYLSDRTGKRKPLVILgYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 138 GAQFGVIIAALISAVVLPAWGW--RGLFFVGIIPVIFA----YLVRKNLDESPEWLAAQKQKRTAKKAEKSKLIQLFATP 211
Cdd:cd17370 132 LDTLGAVLGPLLAALLLYLLGGnyRTIFLLAAIPALLAllilLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVAL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 212 RTaattaalaimatvqIAGYNGLMIWLpsMLQQSQGLSVSSSALWTISTAVGMIAGmLAFGQLIDRIGIKLAYGIFLLAS 291
Cdd:cd17370 212 FA--------------LGNFSFAFLIL--RAQELGLSAALIPLLYALFNLVYALAA-YPAGRLSDRIGRKKLLILGYLSL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 292 ATAVFLYAYASGSAGVLIGGAIVGFFsNGMFAGYG-ALISRYFPVEVRSTATNtIFNFGRAAGGF-SPMLVGFILQHYQM 369
Cdd:cd17370 275 ALAYLGFALGSSLWLLLLGFILWGLY-MGAQESIErAAVADLVPAELRGTAYG-LFNTVVGIGWLlASLIAGYLWDLISP 352
|
330
....*....|....*....
gi 517491048 370 SMAMGYLAALYCISCLAML 388
Cdd:cd17370 353 SAAFLFSAVLALIALLLLL 371
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
16-363 |
6.16e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.79 E-value: 6.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 16 TLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIE 95
Cdd:cd17328 9 LLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 96 QVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAW-GWR-GLFFVGIIPVIFA 173
Cdd:cd17328 89 QLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRwAFRVTGVLGVLLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 174 YLVRKNLDESPewLAAQKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYnGLMIWLPSMLQQSQGLSVSSS 253
Cdd:cd17328 169 ILLLLFVREPP--RGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTG-ALAFWAPTFFLRAFGVGDLSS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 254 A----LWTISTAVGMIAGMLAFGQLIDRIGIK--------LAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGM 321
Cdd:cd17328 246 AdvglIFGAITCIAGVLGVLLGGILADRLRRKtpradplvCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLN 325
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 517491048 322 FAGYGALISRYFPVEVRSTATNTIFNFGRAAG-GFSPMLVGFI 363
Cdd:cd17328 326 WAPVFAILLYVVIPTRRSTASAIQILLSHLLGdAGSPYLIGLI 368
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
31-391 |
9.97e-11 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 63.01 E-value: 9.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 31 MIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVY-VFRFIAGLGAG 109
Cdd:cd17353 28 PLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFlGYGVLGGIGAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 110 GEYGIGMALVAeAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFV-GIIPVIFAYLVRKNLDESPEWLa 188
Cdd:cd17353 108 IGYITPVSTAV-KWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLIlGIIFLIIIVIGAFLIRDPPKGW- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 189 aQKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYNGLMI--WLPSMLQQSQGLSVSSSALWTISTAVGMIA 266
Cdd:cd17353 186 -VPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLigQAKPIGQEFAGLDAGIAALAVSILSIFNGG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 267 GMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGG-AIVGFFSNGMFAGYGALISRYFPVEvRSTATNTI 345
Cdd:cd17353 265 GRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGvALIGFCYGGGFALFPALTADFFGTK-NAGTNYGL 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 517491048 346 FNFGRAAGGFspmLVGFILQHYQmsMAMGYLAALYCISCLAMLTLA 391
Cdd:cd17353 344 LYTAKGVGGL---IGPIIAAYVL--YTGGYNAAFIIAAALSLVALA 384
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
12-187 |
1.17e-10 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 62.89 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 12 VIGLTL--EGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTG 89
Cdd:cd17363 3 VLGLALmaDGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 90 LATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWG----------- 158
Cdd:cd17363 83 FVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGwgfsmgtayqf 162
|
170 180 190
....*....|....*....|....*....|.
gi 517491048 159 --WRGLFFVGIIPVIFAYLVRKNLDESPEWL 187
Cdd:cd17363 163 hsWRVFVIVCALPSVASVVALTFMPESPRFL 193
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
44-187 |
1.31e-10 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 62.65 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLAT-SIEQVYVFRFIAGLGAGGEYGIGMALVAEA 122
Cdd:cd17356 48 GLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIgKWYQLIVGRIIAGLGVGFASVLVPVYQSEV 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517491048 123 WPKNKQGRASSYVSIGAQFGVIIAALIS---AVVLPAWGWRGLFFVGIIPVIFAYLVRKNLDESPEWL 187
Cdd:cd17356 128 APKHIRGTLVSLYQLAITIGILVAYCINygtHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWL 195
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
12-187 |
3.80e-10 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 61.92 E-value: 3.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 12 VIGLTL--EGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTG 89
Cdd:TIGR01299 171 VLGLALmaDGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSS 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 90 LATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWG----------- 158
Cdd:TIGR01299 251 FVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGwsfqmgsayqf 330
|
170 180 190
....*....|....*....|....*....|.
gi 517491048 159 --WRGLFFVGIIPVIFAYLVRKNLDESPEWL 187
Cdd:TIGR01299 331 hsWRVFVIVCAFPCVFAIGALTFMPESPRFF 361
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
44-367 |
3.98e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 60.67 E-value: 3.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGeYGIGMALVAEAW 123
Cdd:cd17330 37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADIT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 124 PKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIFAYLVrknldespewlaaqkqkrtakkaeksk 203
Cdd:cd17330 116 DEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVL--------------------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 204 liQLFATPRTAATTAALAIMATVQIAGYNGLMIWLPSMLQQSqglSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLA 283
Cdd:cd17330 169 --VLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFS---PSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 284 YGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFI 363
Cdd:cd17330 244 LRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL 323
|
....
gi 517491048 364 LQHY 367
Cdd:cd17330 324 YSFL 327
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
44-385 |
5.06e-10 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 60.71 E-value: 5.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVF--RFIAGLGAGGEYGIGMALVAE 121
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIvlRILQGLAQGVTFPAMHALWAK 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 122 AWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFV-GIIPVIFA----YLVRknldesPEW--LAAQkqkr 194
Cdd:cd17318 139 WAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIfGGLGLLWCllwfFLVL------PVWaiVVAH---- 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 195 takkaekskliqlfatprtaattaalaimaTVQIAGYNGLMIWLPSMLQQSQGLSVSSSAL---------WTISTAVGMI 265
Cdd:cd17318 209 ------------------------------FGHNWGFYTLLTELPTYMSDVLHFNIKSNGFlsslpylamWICSIVGGYL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 266 AGMLAFGQLIDRIGI-KLAYGIFLLASATAVFLYAYASGSAGVL-----IGGAIVGFFSNGMFAGYGALISRYFpvevrS 339
Cdd:cd17318 259 ADWLRSRGILSTTTVrKLFTSIGFLGPGVFLIALGYLGSNATLAvvfltLSVGLSGACYSGFLVNHLDLAPNYA-----G 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 517491048 340 TATNTIFNFGRAAGGFSPMLVGFILQHYQMSMA----MGYLAALYCISCL 385
Cdd:cd17318 334 TLMGITNTAATIAGIISPLIVGAIVKNDQTIGQwrivFFISAAIYILGAI 383
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
45-175 |
7.75e-10 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 59.90 E-value: 7.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 45 FISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWP 124
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 517491048 125 KNKQGRASSYVSIGAQFGVIIAALIsAVVLPAWGWRgLFFVGIIPVIFAYL 175
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALL-AYLIRDWRWL-QLAISLPGLLFLLL 157
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
18-171 |
8.66e-10 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 59.86 E-value: 8.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 18 EGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQV 97
Cdd:cd17372 11 EAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWL 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517491048 98 YVFRFIAGLGAGGeYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVI 171
Cdd:cd17372 91 IILRCLVGLGLGG-GPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSS 163
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
23-390 |
1.05e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 59.55 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 23 MFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRF 102
Cdd:cd17329 17 MVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 103 IAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLpAWGWRGLFFVGIIPVIFAYLVrkNLDE 182
Cdd:cd17329 97 LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALV--LLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 183 SPEWLAAQKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYnglmiwLPSMLQQSQGLSVSS-SALWTISTA 261
Cdd:cd17329 174 LPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLEST------LPVYVVEILGLGESLlGLLLALNAL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 262 VgMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRST- 340
Cdd:cd17329 248 L-IVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSy 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 517491048 341 --ATNTIFNFGRAAGgfsPMLVGFILQHYQMSMAMGYLAALYCISCLAMLTL 390
Cdd:cd17329 327 mgFYALAWGLGRAIG---PLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
29-390 |
1.37e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 59.24 E-value: 1.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 29 MSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGA 108
Cdd:cd06180 22 LPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAAS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 109 GGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAAL-ISAVVLPAWGWRGLFFV-GIIPVIFAYLVRKNLDESPEW 186
Cdd:cd06180 102 AFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLlVPAGLGGGLSWRAGWLAlALLSAVLLLLSFLLLRRGPSA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 187 LAAQKQKRTAkKAEKSKLIQLFATPRTAAttaalaimatvqiAGYNGLMIWLPSMLQQSQGLSVSSSALWTIsTAVGMIA 266
Cdd:cd06180 182 PTEASAAESA-PGLNRPLWRLALAYGLFG-------------FGYIITATFLPLIARETGAGSLLAGLLWSL-FGLAAVP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 267 GMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAgYGALISRYFPVEVRSTA---TN 343
Cdd:cd06180 247 SCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITA-LVMALARELAPPAAPRAlalMT 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 517491048 344 TIFNFGRAAGgfsPMLVGFILQHYQMSMAMGYLAALYCISCLAMLTL 390
Cdd:cd06180 326 ASFGVGQILG---PLLAGWLADATGGFAPALILAAAALVVAALLALL 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
52-390 |
1.40e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.17 E-value: 1.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 52 LGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLAT-----SIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKN 126
Cdd:cd06173 45 LPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 127 KQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVG----IIPVIFAYLVRKNldespewlaAQKQKRTAKKAEKS 202
Cdd:cd06173 125 QLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINalsfLLSALLLLFIRRP---------PPAAPGESSSLLLR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 203 KLIQLFATPRTAATTAALAIMATVQIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKL 282
Cdd:cd06173 196 DLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 283 AYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGF 362
Cdd:cd06173 276 LLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL 355
|
330 340
....*....|....*....|....*...
gi 517491048 363 ILQHYQMSMAMGYLAALYCISCLAMLTL 390
Cdd:cd06173 356 LADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
12-257 |
3.53e-09 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 58.50 E-value: 3.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 12 VIGLTL--EGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTG 89
Cdd:cd17439 3 VLGLALmaDGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 90 LATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWG----------- 158
Cdd:cd17439 83 FVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfqmgsayqf 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 159 --WRGLFFVGIIPVIFAYLVRKNLDESPE-----------WLAAQKQKRTAKKAeKSKLIQLFATPRTAATTAALAIMAT 225
Cdd:cd17439 163 hsWRVFVLVCAFPSVFAIGALTTMPESPRfflengkhdeaWMVLKQVHDTNMRA-KGHPERVFSVTHIKRRITLMMMAVW 241
|
250 260 270
....*....|....*....|....*....|...
gi 517491048 226 VQIA-GYNGLMIWLPSMLQQSQGLSVSSSALWT 257
Cdd:cd17439 242 FTMSfSYYGLTVWFPDMIKHLQKSVVFEDSLFE 274
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
13-348 |
3.58e-09 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 58.50 E-value: 3.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 13 IGLTLEGMDIMFISFAMSMIIANFHIDMTKG--------GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIG 84
Cdd:TIGR00879 35 IGGLMFGYDTGVIGGALALPAFEFKFTSANSdsyssslwGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 85 TALTGL---ATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALI-SAVVLPAW--G 158
Cdd:TIGR00879 115 AILMGLaafALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFgSGKVSLNNtlG 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 159 WRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTAKKA--------EKSKLIQLFATPRTAATTAALAIMATV---- 226
Cdd:TIGR00879 195 WRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSlarlrgtsGEDKELLDELELIDIKRSIEKRSVQPSwgsl 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 227 ---------------------QIAGYNGLMIWLPSMLQQSqGLSVSSSALWTIST-AVGMIAGMLAFGqLIDRIGIKLAY 284
Cdd:TIGR00879 275 fsstrrirrrlflgvvlqwfqQFTGINAIMYYSPTIFENA-GVSTDHAFLVSIIVgAVNFAFTFVAIF-LVDRFGRRPLL 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 285 GIFLLASATAVFLYAYASGSAGVLIGGAiVGFFSNGMFAGYGA------------LISRYFPVEVRS------TATNTIF 346
Cdd:TIGR00879 353 LIGAAGMAICLFVLGILGASFVTGSSKS-SGNVAIVFILLFIAffamgwgpvpwvIVSEIFPLSLRPkgisiaVAANWLA 431
|
..
gi 517491048 347 NF 348
Cdd:TIGR00879 432 NF 433
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
56-188 |
4.43e-09 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 58.03 E-value: 4.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 56 VGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQ--------VYVFRFIAGLGAGGEYGIGMALVAEAWPKNK 127
Cdd:PRK15075 71 LGAIVLGAYIDRVGRRKGLIVTLSIMASGTLLIAFVPGYATiglaapllVLLGRLLQGFSAGVELGGVSVYLAEIATPGR 150
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517491048 128 QGRASSYVSIGAQFGVIIAALI--------SAVVLPAWGWRGLFFVG--IIPVIFayLVRKNLDESPEWLA 188
Cdd:PRK15075 151 KGFYTSWQSASQQVAVVFAALLgyllnqwlSPAQMAEWGWRIPFLIGclIVPFIF--LIRRSLEETEEFLA 219
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
226-399 |
5.02e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.43 E-value: 5.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 226 VQIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSA 305
Cdd:pfam07690 7 LAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 306 GVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCL 385
Cdd:pfam07690 87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170
....*....|....
gi 517491048 386 AMLTLAKKTSDGKQ 399
Cdd:pfam07690 167 LLLLPRPPPESKRP 180
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
20-367 |
7.29e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.22 E-value: 7.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 20 MDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMAD----KFGRVRVF-TYTIFLFAIGTALTGLATSI 94
Cdd:COG2211 25 AFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWiLIGAIPLALSFVLLFTAPDL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 95 EQ------VYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQ-GRASSYVSIGAQFGVIIAALISAVVL------PAWGWRG 161
Cdd:COG2211 105 SPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPDYEErTRLSSWRFAFAGLGGLLASVLPPPLVaafggdAALGYRL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 162 LFFVGIIPVIFAYLvrknldespeWLAAQKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYNGLMIWLPSM 241
Cdd:COG2211 185 TALIFAVLGLLAFL----------LTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYY 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 242 LQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAY--GIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSN 319
Cdd:COG2211 255 FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFiiGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLG 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 517491048 320 GMFAGYGALISRYFPVEVRSTATNT------IFNFGRAAG-GFSPMLVGFILQHY 367
Cdd:COG2211 335 AILVLPWAMLADVVDYDEWKTGRRReglyfgIFTFAIKLGqALAGALAGLLLALF 389
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
12-187 |
8.14e-09 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 57.23 E-value: 8.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 12 VIGLTL--EGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTG 89
Cdd:cd17440 3 VLGMALmaDGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 90 LATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWG----------- 158
Cdd:cd17440 83 FVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfsmgsayqf 162
|
170 180 190
....*....|....*....|....*....|.
gi 517491048 159 --WRGLFFVGIIPVIFAYLVRKNLDESPEWL 187
Cdd:cd17440 163 hsWRVFVIVCALPCVSSVVALTFMPESPRFL 193
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-146 |
8.71e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.52 E-value: 8.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 4 RSKTVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAI 83
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517491048 84 GTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIA 146
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
242-410 |
9.11e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.81 E-value: 9.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 242 LQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGM 321
Cdd:COG2223 31 LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 322 FAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAMLTLAKKTSDGKQHN 401
Cdd:COG2223 111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA 190
|
....*....
gi 517491048 402 SISSVSKLA 410
Cdd:COG2223 191 AKASLRDQL 199
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
44-180 |
1.36e-08 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 56.13 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLA------TSIEQVYVFRFIAGLGAGGEYGIGMA 117
Cdd:cd17364 42 GLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSpgstplGVMGWLIFFRFLLGIGIGGDYPLSAT 121
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517491048 118 LVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWG--------------WRGLFFVGIIPVIFAYLVRKNL 180
Cdd:cd17364 122 IMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEhplpagtyhhadlvWRIVLGLGAIPALSVLYFRKHL 198
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
18-189 |
2.04e-08 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 55.58 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 18 EGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQV 97
Cdd:cd17442 13 EAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 98 YVFRFIAGLGAGGeYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIP-----VIF 172
Cdd:cd17442 93 VFLRCMVGCGVSG-HSQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIPgiiliVVF 171
|
170
....*....|....*..
gi 517491048 173 AYLVRKNLDESPEWLAA 189
Cdd:cd17442 172 KFIPRTTLQIWVIWLGI 188
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
52-176 |
2.33e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 55.69 E-value: 2.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 52 LGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRA 131
Cdd:PRK11102 37 LGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRM 116
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 517491048 132 SSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFV-GIIPVIFAYLV 176
Cdd:PRK11102 117 MSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVlALAAILAAALV 162
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
19-176 |
2.36e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 2.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 19 GMDIMFISFAMSMIIA-----NFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATS 93
Cdd:cd17489 200 ALILFLASIAYGAISTflplyAAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGS 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 94 IEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIFA 173
Cdd:cd17489 280 PWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLA 359
|
...
gi 517491048 174 YLV 176
Cdd:cd17489 360 LVL 362
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
47-175 |
2.83e-08 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 54.99 E-value: 2.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 47 SSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKN 126
Cdd:cd17374 41 QSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPR 120
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 517491048 127 KQGRASSYVSIGAQFGVIIAALIsAVVLPAWGWrgLFFVGIIPVIFAYL 175
Cdd:cd17374 121 HRALAITLTSCFFSIGQMLLAGL-AYAIRDWRL--LQLVVSVPFFLFFL 166
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
61-390 |
3.53e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 54.91 E-value: 3.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 61 FGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGeyGIGMALVAEAWPKNKQGRASSYVSIGAQ 140
Cdd:cd17472 52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAIS--SVVMALLADLTREENRTKAMALIGASIG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 141 FGVIIAALISAVVLPAWGWRGLF----FVGIIPVIFAYLVRKNLDEspewlaaqkqKRTAKKAEKSKLIQLFATPRTAAT 216
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGLFlitaILSLVSLLILLFFVPDPPK----------IVQISEKEKKKLKKLLKNKRLLRL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 217 TAALAIMATVQIAgyngLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAgMLAFGQLIDRIGI-KLAYGIFLLASATAV 295
Cdd:cd17472 200 DFSIFILHFVLMA----FFYILPLLLTQLGGGKGQLWKVYLPAILIGFIL-MVPFVIYAEKKGKmKQVFVSSILLIAVGF 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 296 FLYAYASGSAGVLIGGAIVgFFS--NGMFAGYGALISRYFPVEVRSTAT---NTIFNFGRAAGGfspMLVGFILQHYqms 370
Cdd:cd17472 275 LLLLFAATSLWLLIIGLII-FFIgfNLLEALLPSLVSKIAPKEYRGTAMgiyNTSQFLGSFLGG---ALGGLLWGLL--- 347
|
330 340
....*....|....*....|
gi 517491048 371 mamGYLAALYCISCLAMLTL 390
Cdd:cd17472 348 ---GYSSVFLTILILALLWL 364
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
23-176 |
3.86e-08 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 54.62 E-value: 3.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 23 MFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLAT-SIEQVYVFR 101
Cdd:TIGR00886 19 AFSPLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSYSVLLLIR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 102 FIAGLgAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGV---------IIAALISAVVLP---AWGWRGLFFVGIIP 169
Cdd:TIGR00886 99 LFIGI-AGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGgvaqfvmppIIGSLIFGGGQPahlAWGWAFVIVPAGIL 177
|
....*..
gi 517491048 170 VIFAYLV 176
Cdd:TIGR00886 178 LLPALLI 184
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
44-387 |
4.08e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.49 E-value: 4.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAW 123
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 124 PKNKQGRASSYVSIGAQFGVIIAALISAVVLPAwGWRGLFFVGIIPVIFAYLVrknldespewLAAQKQKRTAKKAEKSK 203
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALPFLIAAVLLLLALVPL----------LLTRRAAPEIEEAESIS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 204 LIQLFatPRTAATTAALAIMATVQIAGYNGLMIWLpsmlqQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLA 283
Cdd:cd17477 183 LRRLL--RIAPLALLGAFVAGFLEGAFYSLLPLYG-----LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 284 YGIFLLASATAVFLYAYASGSAGVLIGGAIV-GFFSNGMFAGYGALISRYFPVEVRSTAtNTIFNFGRAAGGFS-PMLVG 361
Cdd:cd17477 256 LLGCALLGALAALLLPLVPGLPLALLVLLFLwGGAAGPLYTLALALAGDRLPGDELVAA-NAALLLLYGLGSVIgPLLAG 334
|
330 340
....*....|....*....|....*.
gi 517491048 362 FILQHYQMSMAMGYLAALYCISCLAM 387
Cdd:cd17477 335 ALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
16-189 |
5.45e-08 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 54.33 E-value: 5.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 16 TLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIE 95
Cdd:cd17437 7 ILLGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 96 QVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVV--LPA-WGWRGLFFVGIIPVIF 172
Cdd:cd17437 87 VLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFsgLPLhVGWRLMLGVGAVPSLF 166
|
170
....*....|....*..
gi 517491048 173 AYLVRKNLDESPEWLAA 189
Cdd:cd17437 167 LAIGVLAMPESPRWTPA 183
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
48-159 |
8.74e-08 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 53.51 E-value: 8.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 48 SITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNK 127
Cdd:cd17379 40 SSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
|
90 100 110
....*....|....*....|....*....|..
gi 517491048 128 QGRASSYVSIGAQFGVIIAALIsAVVLPAWGW 159
Cdd:cd17379 120 RRTVGIVYQMFFTLGLLILPGI-AYFIPHWRW 150
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
62-390 |
8.81e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 53.76 E-value: 8.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 62 GIMADKFGRVRVFTYTIFLFAI-GTALTGLATSIEQVYVFRFIAGLGAGgEYGIGMALVAEAWPKNKQGRASSYVSIGAQ 140
Cdd:cd17490 52 GILSDRIGKRKLFIIIGLLFTVlASLIMILFPSPWGLLIARFLSGIAAA-TWVSFTVLYASYFPPDEAAKAMGLINLVNN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 141 FGVIIAALISAVVLPAWGWRGLFFVGIIPVIFAYLVRKNLDEspewlaaqkqKRTAKKAEKSKLIQLFATPRTAATTAAL 220
Cdd:cd17490 131 LGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKE----------ERREKKPVLTELKELLSVLKDKKLLFFS 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 221 AIMATVQIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAY 300
Cdd:cd17490 201 LLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPF 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 301 ASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTAT---NTIFNFGRAAGgfsPMLVGFILQHYQMSMAMGYLA 377
Cdd:cd17490 281 APNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMgffQAIYALGMFLG---PVLVGIISEAFGLQTGFFVIG 357
|
330
....*....|...
gi 517491048 378 ALYCISCLAMLTL 390
Cdd:cd17490 358 VIALLAAILSLAY 370
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
44-367 |
9.25e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 53.81 E-value: 9.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLgAGGEYGIGMALVAEAW 123
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 124 PKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFF-VGIIPVIFAYLVrknldespewLAAQKQKRTAKKAEKS 202
Cdd:cd17391 118 PKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFiTGGLLFLAFLLT----------LFFVKEDFKPVEKKKM 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 203 KLIQ--LFATPRTAATTAALAIMATVQIAGY--NGLMIWLPSMLQQSQ-------GLSVSSSALWTISTAVGMiagmlaf 271
Cdd:cd17391 188 VSTKevWNSVPNPSLLISLFVTTFIIQLANQsiEPILTLYIRQLMGDAsnlafisGLVFSATGVSSLLSAPRL------- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 272 GQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTA---TNTIFNF 348
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIfgyNQSFQYL 340
|
330
....*....|....*....
gi 517491048 349 GRAAGgfsPMLVGFILQHY 367
Cdd:cd17391 341 GNVAG---PLLGSAIAAHF 356
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
3-206 |
9.54e-08 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 53.96 E-value: 9.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 3 YRSKTVAASVIGLTLEGMDIMFISFAMSMI-IANFHIDMT----KGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYT 77
Cdd:TIGR00887 13 QHFRAIVIAGVGFFTDSYDLFCISLVTKMLgYVYYHGKGPlpssVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGME 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 78 IFLFAIGTALTGLA------TSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISA 151
Cdd:TIGR00887 93 LIIMIIATVASGLSpgsspkSVMATLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQGFGILAGAIVAL 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517491048 152 VVL---------------------PAWG--WRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTAKKAEKSKLIQ 206
Cdd:TIGR00887 173 IVLagfkhsleaaadeasctgscvPAVDymWRILIGFGAVPALLALYFRLTIPETPRYTADVAKDVEQAASDMSAVLQ 250
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
32-391 |
9.71e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 53.40 E-value: 9.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 32 IIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGE 111
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 112 YGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLF-FVGIIPVIFAYLVRKNLDESPewlaAQ 190
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFvVAGLVSILAAVLFWLFYREPP----AA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 191 KQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAgyngLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLA 270
Cdd:cd17475 178 SAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFA----LLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 271 FGQLIDRIG-------IKLAYGIFLLASATAVFLYAYASGSAGVLIgGAIVGFFSNGMFAGYGALISRYFPVEVRSTAT- 342
Cdd:cd17475 254 LGRVSDRVFggrrrpvLVITAAIAAAALLVLSLLSPGTPLWLLVLL-LILLGLFAIGWNGLYLTLVAESAGPEQAGTALg 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 517491048 343 --NTIFNFGRAAGgfsPMLVGFILQHyqmsmAMGYLAALYCISCLAMLTLA 391
Cdd:cd17475 333 laNTINFIGIAIG---PPLFGLLVDA-----THSYAPAWLALALLLVLAAL 375
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
18-175 |
1.62e-07 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 52.89 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 18 EGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQV 97
Cdd:cd17441 11 DAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWI 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517491048 98 YVFRFIAGLGAGGeYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPV-IFAYL 175
Cdd:cd17441 91 LVLRGLVGFGIGG-VPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLlIFAVL 168
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
25-391 |
1.83e-07 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 52.80 E-value: 1.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 25 ISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIE-QVYVFRFI 103
Cdd:cd17314 22 WSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFpLSYACFVF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 104 AGLGAGGEYGIGMaLVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVgIIPVIFAYLVRKNLDES 183
Cdd:cd17314 102 IGAGTGILYGSAV-LVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTI-LGILAAIVLSVVSLLGF 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 184 PEWLAAQKQKRTAKKaeksKLIQLFATPRTAATTAALAIMATVQIAGYNgLMIWLPSMLQQSQGLSVSSSALWTISTAVG 263
Cdd:cd17314 180 KEPPDNQARLHVQKK----KTQTMGEIFRDKVFWILFIAIFLVLIGGFL-FIANMASLVRSLQLDAPSFVTKLMSIYGLF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 264 MIAGMLAFGQLIDRIGIK---LAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRST 340
Cdd:cd17314 255 NAFGRLLWGIVADFFGGRlstLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFAT 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 517491048 341 ATNTIFNFGRAAGGFSPMLVGFIlqhyqMSMAMGYLAALYCISCLAMLTLA 391
Cdd:cd17314 335 LYGILLFAPAIGSILGPMLGAKF-----YDRTPSYISAVYIYAVIVFLASA 380
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
242-409 |
2.19e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.28 E-value: 2.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 242 LQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGM 321
Cdd:COG2814 36 IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 322 FAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAMLTLAKKTSDGKQHN 401
Cdd:COG2814 116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARAR 195
|
....*...
gi 517491048 402 SISSVSKL 409
Cdd:COG2814 196 LRGSLREL 203
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
46-173 |
2.85e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 52.63 E-value: 2.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 46 ISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEyGIGMALVAEAWPK 125
Cdd:cd06179 37 ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPN 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 517491048 126 NKQGRASSYVSIGAQFGVIIAALISAVVLPAW--GWRGLFFVGIIPVIFA 173
Cdd:cd06179 116 KYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYINAIFNALA 165
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
46-354 |
4.74e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 51.48 E-value: 4.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 46 ISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPK 125
Cdd:cd17327 46 GNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKR 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 126 NKQGRASSYVSIGAQFGVIIAALISAVVL------PAWGWRGLFFV-GII-----PVIFAYLVRKN-----LDESPEWLA 188
Cdd:cd17327 126 EEQAKRIAFFYAAAGLGSIFGGLLAYGVFkilgvgGLAGWRWLFIIeGLItiiigLVIFFWLPDNPskawfLTEEEKELA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 189 AQKQKR--TAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGyNGLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIa 266
Cdd:cd17327 206 VERLRAnqTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITN-NGISNFLPLILKSLGFYSLQTNLLSVPIGALGAV- 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 267 GMLAFGQLIDRIGIKLAYGIFLLASATAVF-LYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTATNTI 345
Cdd:cd17327 284 SLLIAALLSDRFKKRGLFAIFACVLALVGSiILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAI 363
|
....*....
gi 517491048 346 FNFGRAAGG 354
Cdd:cd17327 364 MLIFYNVGN 372
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
10-349 |
6.56e-07 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 51.20 E-value: 6.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 10 ASVIGLtLEGMDIMFISFAMSMI-------IANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFA 82
Cdd:cd17362 2 PALGGL-LFGYDIGATSGALLSItspalsgTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 83 IGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPA-WGWRG 161
Cdd:cd17362 81 VGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVvGGWRY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 162 LFFVGIIPVIFAYLVRKNLDESPEWlaaQKQKRTAKKAEKSklIQLFatprtaattaalaimatVQIAGYNGLMIWLPSM 241
Cdd:cd17362 161 MYGLAAPPALLLGIGMWFLPPSPRW---QGNYRKPLIIGLG--LVLF-----------------QQITGQPSVLYYAATI 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 242 LqQSQGLSVSSSALwTISTAVG---MIAGMLAFGqLIDRIGIK---------LAYGIFLLAsATAVFLYAYASGSAGVLI 309
Cdd:cd17362 219 F-KSAGFSAASDAT-LVSVGLGvfkLLMTIVAVL-LVDKLGRRplllggvsgMVVSLFLLA-AYNLFVQMGPAGLAWLSL 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 517491048 310 GG--AIVGFFSNGMFAGYGALISRYFPVEVRSTATN--TIFNFG 349
Cdd:cd17362 295 VAllLYVGAYQISFGPISWLMVSEIFPLRVRGRAIAlaVLVNFG 338
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
30-388 |
6.82e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 51.01 E-value: 6.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 30 SMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFG-RVRVFTYTIFLFaIGTALTGLATSIEQVYV-FRFIAGLG 107
Cdd:cd17352 27 VELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGcRPVAIAGGLLAA-LGLLLSSFATSLWQLYLtYGVLGGLG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 108 AGGEYGIGMALVAEaWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRG--LFFVGIIPVIFAYlvrknldespe 185
Cdd:cd17352 106 LGLIYSPAIVIVGQ-YFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGalLILGGLCLNLCVC----------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 186 wlaaqkqkrtakkaekSKLIQLFATPRTAATTAALAIMATvqiaGYNGLMIWLPSMLqQSQGLSVSSSALWTISTAVGMI 265
Cdd:cd17352 174 ----------------GLLLRLLKDPTFVLLALGVSFAML----GFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 266 AGMLAFGQLIDRIGIKLAY--GIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTATN 343
Cdd:cd17352 233 VGRILLGLLADKPRIGRLYlyIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 517491048 344 TIFNFGRAAGGFSPMLVGFILqhyqmSMAMGYLAALYCISCLAML 388
Cdd:cd17352 313 LVLLFQGLAALVGPPIAGLLR-----DYTGDYDAAFYFCGACLLL 352
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
56-199 |
7.50e-07 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 50.96 E-value: 7.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 56 VGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVF--------RFIAGLGAGGEYGIGMALVAEAWPKNK 127
Cdd:PRK10406 78 IGGWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWapallllaRLFQGLSVGGEYGTSATYMSEVAVEGR 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 128 QGRASS--YVS-IGAQF-----GVIIAALISAVVLPAWGWRGLFFVGIIPVIFAYLVRKNLDESpewlaAQKQKRTAKKA 199
Cdd:PRK10406 158 KGFYASfqYVTlIGGQLlallvVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET-----SQQETRALKEA 232
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
36-178 |
8.35e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 50.63 E-value: 8.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 36 FHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLA--TSIEQVYVFRFIAGLGAGGEYG 113
Cdd:cd17380 29 FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILSRILLGLGEGVHFP 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517491048 114 IGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFV-GIIPVIFAYLVRK 178
Cdd:cd17380 109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFfGLLGLLWALVWLI 174
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
52-363 |
1.35e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 50.07 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 52 LGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRA 131
Cdd:TIGR00710 51 LGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 132 SSYVSIGAQFGVIIAALISAVVLPAWGWRGLF-FVGIIPVIFAYLVrknldespeWLAAQKQKRTAKKAEKSKLIQLFAT 210
Cdd:TIGR00710 131 YSILMPVLALAPAVAPLLGGYILVWLSWHAIFaFLSLAGILLSALI---------FFILPETLPYEARIQISTYFETFLL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 211 PRTAATTAALAIMATVQIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIK----LAYGI 286
Cdd:TIGR00710 202 LLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKsllrMGLIL 281
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517491048 287 FLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGM-FAGYGALISRYFPvEVRSTATNTIFNFGRAAGGFSPMLVGFI 363
Cdd:TIGR00710 282 FAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMiSSIAMAYALEDFP-HVAGTASALFGTLRLVLGAIVGYLVSLI 358
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
44-176 |
2.23e-06 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 49.53 E-value: 2.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLgAGGEYGIGMALVAEAW 123
Cdd:PRK09874 57 GLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQV 135
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 517491048 124 PKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIFAYLV 176
Cdd:PRK09874 136 PRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLV 188
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
29-406 |
4.16e-06 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 48.38 E-value: 4.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 29 MSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGA 108
Cdd:PRK03699 30 MGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAMFVLGVVS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 109 GGEYGIGMALVAEAWPKNKQGRA----SSYVSI-GAQFGVIIAALISAVVlpAWGWRGLfFVGIIPV-IFAYLVRKNLDe 182
Cdd:PRK03699 110 GITMSIGTFLITHVYEGKQRGSRllftDSFFSMaGMIFPIIAAYLLARSI--EWYWVYA-CIGLVYVaIFILTLFSEFP- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 183 spewLAAQKQKRTAKKAEKSKLiqlfatprtAATTAALAIMATVQIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAV 262
Cdd:PRK03699 186 ----ALGKHAPKADKPVAKEKW---------GIGVLFLAIAALLYILAQLTFISWVPEYAQKKFGMSLEDAGNLVSNFWM 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 263 GMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYGALISryFPVEVRS-TA 341
Cdd:PRK03699 253 AYMVGMWIFSFIVRFFDLQRILTVLAGLALVLMYLFVNTDDPSHLLYAILGLGFFSSAIYTTIITLGS--QQTKVASpKL 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517491048 342 TNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLaMLTLAKKTSDGKQHNSISSV 406
Cdd:PRK03699 331 VNFILTCGTIGTMLTFVVTSPIVAHFGLQAALLTANGLYAVVFV-MCILLGFVSKHRQHGALTAH 394
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
48-159 |
7.83e-06 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 47.41 E-value: 7.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 48 SITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNK 127
Cdd:cd17446 40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
90 100 110
....*....|....*....|....*....|....*
gi 517491048 128 Q---GRASSYVSIGAQFgvIIAALisAVVLPAWGW 159
Cdd:cd17446 120 RavvGTLLGYCYTLGQL--ILAGV--AYAIRDWRW 150
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
11-165 |
8.64e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.62 E-value: 8.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 11 SVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGL 90
Cdd:cd17475 204 AIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLV 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 91 ------ATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIA-ALISAVVLPAWGWRGLF 163
Cdd:cd17475 284 lsllspGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGpPLFGLLVDATHSYAPAW 363
|
..
gi 517491048 164 FV 165
Cdd:cd17475 364 LA 365
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
35-344 |
1.01e-05 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 47.56 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 35 NFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGI 114
Cdd:cd17433 35 ALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 115 GMALVAEAWPKNKQGRASSYVSIGAQFGvIIAALISAVVLPawgWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKR 194
Cdd:cd17433 115 VPVYISEIAHPRVRGTLGSCVQLMVVIG-IMGAYLAGLVLD---WRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQ 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 195 TAKKA--------------------------EKSKLIQLFATPRTAATTAALAIMATVQIAGYNGLMIWLPSMLQQSQgl 248
Cdd:cd17433 191 EAMAAlrflrgpdqgwewecigieqsfhleeQSFSLALLKQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAK-- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 249 sVSSSALWTISTAVGMIAGMLAFGQLIDRIGIK--LAYGIFLLASATAVFLYaYASGSAGVLIGGAIVGFFSNGMFagyg 326
Cdd:cd17433 269 -FKDSSVASVIVAAIQVLFTAVAALIMDRAGRKvlLVLSGVVMVFSTAAFGW-LAVGSMGFFIAGFAVGWGPIPWL---- 342
|
330
....*....|....*...
gi 517491048 327 aLISRYFPVEVRSTATNT 344
Cdd:cd17433 343 -VMSEIFPLHVRGVASGI 359
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
44-172 |
1.33e-05 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 46.97 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMAD-KFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEA 122
Cdd:cd17378 36 GLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEP 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 517491048 123 WPKNKQGRASSYVSIGAQFGVIIAALISavVLPAWGWRGLFFVGIIPVIF 172
Cdd:cd17378 116 VGPKWRGQVGMSTFFFFVLGFMSLPGIA--YLNGSSWRVLYFWTSIPALI 163
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
4-176 |
1.67e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.44 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 4 RSKTVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAI 83
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 84 GTALTGLA--TSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRG 161
Cdd:cd17316 256 LALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335
|
170
....*....|....*
gi 517491048 162 LFFVGIIPVIFAYLV 176
Cdd:cd17316 336 VPALILALLAIVALI 350
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
4-176 |
2.87e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.00 E-value: 2.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 4 RSKTVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAI 83
Cdd:cd17324 197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 84 GTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKqGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLF 163
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
170
....*....|...
gi 517491048 164 FVGIIPVIFAYLV 176
Cdd:cd17324 356 WVGAALLLLALLL 368
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
44-168 |
3.30e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 45.89 E-value: 3.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 44 GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVF--RFIAGLGAGGEYGIGMALVAE 121
Cdd:TIGR00894 79 GLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVfcRVIQGLAQGSVSPATHKIIVK 158
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 517491048 122 AWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAW-GWRGLFFVGII 168
Cdd:TIGR00894 159 WAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGI 206
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
55-324 |
3.69e-05 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 45.70 E-value: 3.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 55 LVGGMVF----GIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGR 130
Cdd:PRK15402 58 LAGGMFLqwllGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIK 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 131 ASSYVSIGAQFGVIIAALISAVVLPAWGWRGLF-FVGIIPVI-FAYLVRKnldeSPEWLAAQKQKRTAKKAEKSKLiQLF 208
Cdd:PRK15402 138 ITALMANVALLAPLLGPLVGAALIHVLPWRGMFvLFAALAALsFFGLWRA----MPETAGRVGEKLSLKELGRDYK-LVL 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 209 ATPRTAATTAAlaimatvqiAGYNG--LMIWL---PSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIG---- 279
Cdd:PRK15402 213 KNRRFVAGALA---------LGLVSlpLLAWIalsPVILISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPlrsl 283
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 517491048 280 IKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGM-FAG 324
Cdd:PRK15402 284 IRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYAFGIGLaNAG 329
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
247-398 |
3.96e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 45.32 E-value: 3.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 247 GLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYG 326
Cdd:cd17341 30 GLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAGANFASGQ 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517491048 327 ALISRYFPVEVRSTATNTIFNFGRAAGGFS----PMLVGFILQ---HYQMSMAMGYLAALYCISCLAMLTLAKKTSDGK 398
Cdd:cd17341 110 PWASFWFPKEKIGGAAGGIAGAGNMGVAVSqllaPLIAGAIVFdggFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTGK 188
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
22-168 |
4.22e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 45.29 E-value: 4.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 22 IMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFtytIFLFAIGTALTGLATSIEQVYV-- 99
Cdd:cd17353 230 LMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTL---SIAFLIQGVAMFLLPFIGSVAVlf 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517491048 100 --FRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGII 168
Cdd:cd17353 307 vlGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAA 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
4-147 |
4.40e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 4.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 4 RSKTVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAI 83
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517491048 84 GTALTGLATSIEQ---VYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAA 147
Cdd:pfam07690 278 AALGLLLLSLTLSslwLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
56-173 |
4.42e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.23 E-value: 4.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 56 VGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYV 135
Cdd:cd17370 249 LAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLF 328
|
90 100 110
....*....|....*....|....*....|....*...
gi 517491048 136 SIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIFA 173
Cdd:cd17370 329 NTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIA 366
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
17-334 |
5.66e-05 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 45.03 E-value: 5.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 17 LEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGR-----VRVFTYTIFLFAIgtaltGLA 91
Cdd:cd17396 11 VHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRkpsvlLGMVLYALFFVGI-----LFS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 92 TSIEQVYVFRFIAGLG-AGGEYGIGMALVaEAWPKnKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFV---GI 167
Cdd:cd17396 86 PNLIIAYVFALLAGAAnSFLDTGTYPALM-EAFPK-ASGSANILVKAFVSFGQFLLPFIIAFLAANNLWYGWSFIvpaAV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 168 IPVIFAYLVRKNLDESPEWLAAQKQKRTAKKAEKSKLIqlfatprtaATTAALAIMATVQIAGYNGLMIWLPSMLQQSQG 247
Cdd:cd17396 164 LVLNALLLLKLSFPPQTVTAANTKQKEIPVKREKPKFL---------IEGIALILIGFTSTATFYLFSQWMPKYGSAVAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 248 LSVSSSALWTISTAVGMIAGMLAFGQLIDR----IGIKLAYGIFLLASATAVFLYayaSGSAGVLIGGAIVGFFSNGMFA 323
Cdd:cd17396 235 MGEAESLKLISYYSMGSLVCVFITAVLLKRyvrpIWILVLYPIISLLALFVLYLV---PSPDVCILGAFVIGFFAAGGVL 311
|
330
....*....|..
gi 517491048 324 GYG-ALISRYFP 334
Cdd:cd17396 312 QLGlTLMAEFFP 323
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
42-175 |
6.46e-05 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 44.77 E-value: 6.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 42 KGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAE 121
Cdd:cd17377 40 KVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNE 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 517491048 122 AWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPawgWRGLFFVGIIPVIFAYL 175
Cdd:cd17377 120 CVGKSYWALAGSLGGLFFAVGIAQYALLGYFIRS---WRTLAVVVNLQGTLVFL 170
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
12-176 |
6.85e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.56 E-value: 6.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 12 VIGLTLEGMDIMFISFAMSMIIANFHIDMTKG--------GFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAI 83
Cdd:cd17391 203 LISLFVTTFIIQLANQSIEPILTLYIRQLMGDasnlafisGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 84 GTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLF 163
Cdd:cd17391 283 LYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVF 362
|
170
....*....|...
gi 517491048 164 FVGIIPVIFAYLV 176
Cdd:cd17391 363 VVTALLVLLNAIW 375
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
244-408 |
7.94e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.49 E-value: 7.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 244 QSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFA 323
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 324 GYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALYCISCLAMLTLAKKTSDGKQHNSI 403
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAV 183
|
....*
gi 517491048 404 SSVSK 408
Cdd:cd17325 184 SAARL 188
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
48-201 |
1.78e-04 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 43.48 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 48 SITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGL---ATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWP 124
Cdd:cd17431 57 AIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLsklAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 125 KNKQGRASSYvsigAQFGVIIAALISAVV-LP-----AWGWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRT-AK 197
Cdd:cd17431 137 TALRGALGTL----HQLGIVVGILISQIFgLEfilgtEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEeAK 212
|
....
gi 517491048 198 KAEK 201
Cdd:cd17431 213 SVLK 216
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
242-367 |
2.12e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.88 E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 242 LQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGM 321
Cdd:COG0477 40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL 119
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 517491048 322 FAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHY 367
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL 165
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
60-299 |
3.13e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 42.63 E-value: 3.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 60 VFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPK-NKQGRASSYVSIG 138
Cdd:cd17476 52 IFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGAT 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 139 AQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIF---AYLVRKNLDESPEWLAAqkqkrtakkaekskliqlfatprtaa 215
Cdd:cd17476 132 APLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIvavAAIFWTSPSFIAVLLAV-------------------------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 216 ttaalaimaTVQIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAV 295
Cdd:cd17476 186 ---------FLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMAISMVAFLVGP 256
|
....
gi 517491048 296 FLYA 299
Cdd:cd17476 257 ILFA 260
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
11-196 |
3.26e-04 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 42.76 E-value: 3.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 11 SVIGLTLEGMDIMFI-SFAMSMIIANFHIdmtkgGFISSITNLGMLVGGMVFGIMADKFGR---VRVFTYTIFLFAIGTA 86
Cdd:PRK10077 29 AVISGTVESLNTVFVaPQNLSESAANSLL-----GFCVASALIGCIIGGALGGYCSNRFGRrdsLKIAAVLFFISALGSA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 87 LTGL---------ATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYvsigAQFGVIIAALI-------- 149
Cdd:PRK10077 104 WPEFgftsigpdnTGYVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSF----NQFAIIFGQLVvyfvnyfi 179
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 517491048 150 ----SAVVLPAWGWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTA 196
Cdd:PRK10077 180 arsgDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQA 230
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
4-176 |
3.72e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.41 E-value: 3.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 4 RSKTVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADK-FGRVRVFTYTIFLFA 82
Cdd:cd06174 202 NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 83 IGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPA-WGWRG 161
Cdd:cd06174 282 LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTG 361
|
170
....*....|....*
gi 517491048 162 LFFVGIIPVIFAYLV 176
Cdd:cd06174 362 AFLVLAVLLLLAAIL 376
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
233-366 |
4.99e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 4.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 233 GLMIWLPSMlQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAY----GIFLLASATAVFlyayaSGSAGVL 308
Cdd:cd17321 14 IVNVALPTI-ARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFliglALFGLASLLCAL-----APSLAFL 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 517491048 309 IGG-AIVGFFSNGMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQH 366
Cdd:cd17321 88 IAArALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLEL 146
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
45-199 |
5.71e-04 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 41.83 E-value: 5.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 45 FISSITNLGMLVGGMVFGIMADKFGRVRVFTY-TIFLF--AIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAE 121
Cdd:cd17432 54 LTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLnNIFAIvaAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGE 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 122 AWPKNKQGRASSYVSIGAQFGVIIAAL--ISAVVLPAWGWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQ-KRTAKK 198
Cdd:cd17432 134 SAPKNLRGAVGLVPAIFITLGILLGQVlgLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGdEEAARK 213
|
.
gi 517491048 199 A 199
Cdd:cd17432 214 A 214
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
26-394 |
5.91e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 41.94 E-value: 5.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 26 SFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFgRVRVftytifLFAIGTALTGLATSI----EQVYVFR 101
Cdd:cd17343 23 SFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQI-SARW------LFSSGLVLSGLTTVAfsgsSSVWVFS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 102 ---FIAGLGAGGEYGiGMALVAEAWPKNKQ-GRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLF----FVGIIPVIFA 173
Cdd:cd17343 96 ilwFLNGLAQGLGWP-PCAKILRKWFSPSQfGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLsisgTVAVVMSVVC 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 174 YLVRKNlDESPEWL-----AAQKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAgyngLMIWLPSMLQQSQGL 248
Cdd:cd17343 175 LLFIKN-EPSDVGLnnieeEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTA----VTDWGQLFLIQDKGQ 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 249 SVSSSALWTISTAVGMIAGMLAFGQLID--------------RIGIKLAYGIFLLASATA-VFLYAYASGSAGVLIGGAI 313
Cdd:cd17343 250 SALTGSSFMSSLEVGGFVGSIAAGYLSDwavakhgsssrgnpRMPLALVFMAGLTVSLHLfRVHITSDSSELFILLLGFL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 314 VGFFSNGMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMGYLAALyCISCLAMLTLAKK 393
Cdd:cd17343 330 IGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEIL-CAITVVILFLLRN 408
|
.
gi 517491048 394 T 394
Cdd:cd17343 409 I 409
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
23-175 |
8.31e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.02 E-value: 8.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 23 MFISFAMSMIIANFHIDM---------TKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATS 93
Cdd:cd17330 184 FLIALAFAGLESVFSLFLkdrfgfspsQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 94 IEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRA----SSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIP 169
Cdd:cd17330 264 VPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAqgiiQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIA 343
|
....*.
gi 517491048 170 VIFAYL 175
Cdd:cd17330 344 LFLLSL 349
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
32-390 |
1.43e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.70 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 32 IIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLA-TSIEQVYVFRFIAGLGaGG 110
Cdd:cd17341 25 IRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGFLLGFA-GA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 111 EYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAW-------GWRGLFFV-GIIPVIFAYLVRKNLDE 182
Cdd:cd17341 104 NFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIvfdggfvGWRNAFFVpGILLAIAAVLVLLFGDD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 183 SPEWLAAQKQKRTAKKAekskliqlfatPRTAATTAALAIMATVQIAGYNGLMIWLPSMLQQSQGLSVSSSALWTISTAV 262
Cdd:cd17341 184 LPTGKASALEFLKVQLA-----------VLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 263 GMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNGMFAGYG-----ALISRYFPVEV 337
Cdd:cd17341 253 AGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGngsvfRMVPFIFRREL 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 517491048 338 rSTATNTIFNFGRAAGGFSPMLVGFILQHYQM-SMAMGYLAALYcISCLAMLTL 390
Cdd:cd17341 333 -GAVTGLVGAIGGLGGFFLPLLFGSSALMTGSgVGAFSLFGVLA-VACTLLVWL 384
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
7-195 |
1.78e-03 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 40.17 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 7 TVAASVIGLTLEGMDIMFISFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTA 86
Cdd:cd17436 2 TATVSLLGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 87 LTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSIGAQFGVIIA-ALISAVVLPAWGWRGLFFV 165
Cdd:cd17436 82 ILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISyALNYFFSNVLTGWRYMFGL 161
|
170 180 190
....*....|....*....|....*....|
gi 517491048 166 GIIPVIFAYLVRKNLDESPEWLAAQKQKRT 195
Cdd:cd17436 162 AIIPAAIQFASILLLPKKPEVLNIKDNMRR 191
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
59-173 |
2.23e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.84 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 59 MVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPkNKQGRASSYVSIG 138
Cdd:cd17471 253 LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMP-GQPGLATTLYSNA 331
|
90 100 110
....*....|....*....|....*....|....*
gi 517491048 139 AQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIFA 173
Cdd:cd17471 332 SRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLA 366
|
|
| MFS_SLC22A16_CT2 |
cd17375 |
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ... |
46-172 |
2.32e-03 |
|
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 39.73 E-value: 2.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 46 ISSITNLGMLVGGMVFGIMADKFGRVRVFTYT---IFLFAIGTALTGLATSIeqvYVFRFIAGLGAGGEYGIGMALVAEA 122
Cdd:cd17375 40 IQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTstgQFVFGIAVAFTFDYYSF---VIVRFLLAMVSSGYLVVVFVYVTEF 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 517491048 123 WPKNKQGRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIF 172
Cdd:cd17375 117 TGIKARTWASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLVTIPFIL 166
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
52-379 |
2.68e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.55 E-value: 2.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 52 LGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAG-GEYGIGMALVA--EAWPKNKQ 128
Cdd:cd17393 45 VGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGaLDVAMNAQGVAveRAYGRPIM 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 129 GRASSYVSIGAQFGVIIAALISAVVLPAWGWRGLFFVGIIPVIFAYlVRKNLDESPEwlaaqkqKRTAKKAEKSKLIQLF 208
Cdd:cd17393 125 SSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVA-IRALLPGTGE-------AAEDRPDGAGKPGFLL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 209 ATPRTAATTAALAIMATVQIAGYNglmiWLPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFL 288
Cdd:cd17393 197 PNRLLLLLGLLALAAALAEGAAAD----WSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 289 LASATAVFLYAYASGSAGVLIGGAIVGFfsnGMFAGYGALISR--YFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQH 366
Cdd:cd17393 273 LLAALGLLLALLAPSVWVALAGFALMGL---GLSVVVPLAFSAagALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADA 349
|
330
....*....|...
gi 517491048 367 YQMSMAMGYLAAL 379
Cdd:cd17393 350 TGLRTAFLVVALL 362
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
238-374 |
3.62e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 39.52 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 238 LPSMlQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAGVLIGGAIVGFF 317
Cdd:cd17438 22 LPSA-EKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFG 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 517491048 318 SNGMFAGYGALISRYFPVEVRSTATNTIFNFGRAAGGFSPMLVGFILQHYQMSMAMG 374
Cdd:cd17438 101 IGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWGFSMG 157
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
37-199 |
4.63e-03 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 39.05 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 37 HIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGM 116
Cdd:cd17434 37 HLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIP 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 117 ALVAEAWPKNKQGRASSYVSIGAQFGVIIAALIsAVVLPawgWRGLFFVGIIPVIFAYLVRKNLDESPEWLAAQKQKRTA 196
Cdd:cd17434 117 VYVSEISHPGVRGALGACPQIMAVFGSLALYAL-GLLLP---WRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKA 192
|
...
gi 517491048 197 KKA 199
Cdd:cd17434 193 LKA 195
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
48-178 |
6.41e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 38.46 E-value: 6.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 48 SITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNK 127
Cdd:PRK10473 45 SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRR 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 128 QGRASSYVSigaqfGVI-----IAALISAVVLPAWGWRGLFF----VGIIPVIFAYLVRK 178
Cdd:PRK10473 125 RAKVLSLLN-----GITciipvLAPVLGHLIMLKFPWQSLFYtmaaMGILVLLLSLFILK 179
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
37-176 |
6.42e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 38.45 E-value: 6.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 37 HIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRvRVFTYTIFLFAIGTAL--------TGLATSIeqvyVFRFIAGLGA 108
Cdd:cd17344 243 ILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGG-RATTCAAMLILAAPMLfiynyfgqVSMTTNI----VLLIVCGLLV 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 109 GGEYG-IGMALVAE-AWPKNKQG--RASSYV--------SIGAQFGVIIAALISAVvlpawGWRGLFFVGIIPVIFAYLV 176
Cdd:cd17344 318 NGPYAlITTAVSADlGTHKSLKGnaRALATVtaiidgtgSIGAALGPLLAGLISSR-----GWNNVFYMLIAADVCAGLL 392
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
26-389 |
6.73e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 38.38 E-value: 6.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 26 SFAMSMIIANFHIDMTKGGFISSITNLGMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLA----TSIEQVYVFR 101
Cdd:cd17345 23 SLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVpsatSSVGLMFILL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 102 FIAGLGAGGEYGIGMALVAEAWPKNKQGRASSYVSI----GAQFGVIIAALISAVVLPAWgWRGLFFV-GIIPVIFAYLV 176
Cdd:cd17345 103 FLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNIshnvGGGLVGPLAGLGLAIFGDGW-WRGAFIFpAIIAIIVAVIV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 177 RKNLDESPEWL------------AAQKQKRTAKKAEKSKLIQLFATPRTAATTAALAIMATVQIAGYnGLMIWLPSMLQQ 244
Cdd:cd17345 182 LFLGKDTPESEglppieeykgdyPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIANVFVYLVRY-GILDWAPTYLSE 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 245 SQGLSVsSSALWTIST-AVGMIAGMLAFGQLIDRI--GIKLAYG-IFLLASATAVFLYAYASGSAGVLIGGAIVGFFSNG 320
Cdd:cd17345 261 VKGFSK-AQAMWAFSLfEWAAIPGTLLAGWLSDKLfkGRRAPTGiIFMILVIVALIVYWLAPNVLVDLIALIALGFLIYG 339
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517491048 321 --MFAGYGALisRYFPVEVRSTATNTIFNFGRAAGG-FSPMLVGFILQHY--QMSMAMGYLAALYCISCLAMLT 389
Cdd:cd17345 340 pvMLIGLQAL--ELVPKKAAGTAAGLTGLFGYLGGSvLATALIGIIVDHFgwNGGFIVLLASCILAIIFLALVA 411
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
46-172 |
8.65e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 38.25 E-value: 8.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 46 ISSITNLGMLVGGMVFGIMADKFGRVRvftyTIFLF-AIGTALTGLAT-SIEQVYVFRFIAGLGAGGEYGIGM------- 116
Cdd:cd17337 249 IWGIIFLVNIFFNLIFGILGDKIGWRR----TVRWFgGVGCAISTLLFyYVPQLFGHNYWAALIAAILFGIGLagfvpls 324
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517491048 117 ALVAEAWPKNKqGRASSYVSIGAQFGVIIAALISAVVLPA-------WGWRGLFFVGIIPVIF 172
Cdd:cd17337 325 ALMPSLAPEHK-GAAMSILNLGAGLSNFVGPAIVTLFLGSfgaggvvWIFAGLYLLSAVLTLF 386
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
233-341 |
9.01e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.05 E-value: 9.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 233 GLMIW------LPSMLQQSQGLSVSSSALWTISTAVGMIAGMLAFGQLIDRIGIKLAYGIFLLASATAVFLYAYASGSAG 306
Cdd:TIGR00886 13 SFLVWfafsplAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYS 92
|
90 100 110
....*....|....*....|....*....|....*
gi 517491048 307 VLIGGAIVGFFSNGMFAGYGALISRYFPVEVRSTA 341
Cdd:TIGR00886 93 VLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTA 127
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
53-165 |
9.22e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 37.95 E-value: 9.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517491048 53 GMLVGGMVFGIMADKFGRVRVFTYTIFLFAIGTALTGLATSIEQVYVFRFIAGLGAGGEYGIGMALVAEAWPKNKQGRAs 132
Cdd:PRK11043 53 GFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRV- 131
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 517491048 133 syvsigaqFGVI---------IAALISAVVLPAWGWRGLFFV 165
Cdd:PRK11043 132 --------FATImplvalspaLAPLLGAWLLNHFGWQAIFAT 165
|
|
| |
