|
Name |
Accession |
Description |
Interval |
E-value |
| strep_PBP3 |
NF038273 |
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ... |
12-416 |
1.59e-134 |
|
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.
Pssm-ID: 468443 [Multi-domain] Cd Length: 407 Bit Score: 392.70 E-value: 1.59e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 12 FLASLLAAGTFQLPKKAYAqDDINVHAKAAILVEASTGKILYKKNADQALGIASMSKMMTEYILLKAIKEKKVSWDQKVT 91
Cdd:NF038273 3 LILLLLLLLAFFLATTVSA-DDFDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTPVK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 92 ISDYAYKISQNRDLSNVPLrQGGKYTLKELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQAKAFGLTHYKFVNSSG 171
Cdd:NF038273 82 ISDYPYELTTNYEISNVPL-DARKYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNASG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 172 LNNADLqgmqpdrGD-------ATEENAMSARSAAKVAYHLVNDFPEMLKTSSIPEKKFrpgtkDEIDMKNWNWMLPSLV 244
Cdd:NF038273 161 LNNSYL-------GDhiypgskKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADF-----AGTTIYSYNYMLKGMP 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 245 YGKEGVDGLKTGTTDYAGYCFTGTAEQNGMRVITVVLHATNAQGKGgyKARFDETSKLMDYAFNNYSMKTLYPKGYSVKN 324
Cdd:NF038273 229 YYREGVDGLKTGTTEKAGASFVATSVENGMRVITVVLNADNADEDE--YARFTATNQLLDYIYQNFEKVTLVKKGQAYKD 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 325 KKtITVKAGKEKQAPIVTEAPLKAPIKNGESHMYTPVVKLEKQQINAPVKKGTSVGTLLAKHKGGQEPGYLYGPdsPHVD 404
Cdd:NF038273 307 SK-LPVIDGKKKTVSAVAKKDLTVIQKIGTDSKPSVKFTPKKKELTAPIKKGQVVGKATFKDKDLIGKGYLGEP--PSVE 383
|
410
....*....|..
gi 517494710 405 VVVKNGVEKANW 416
Cdd:NF038273 384 LVAKKDVKKSFF 395
|
|
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
1-417 |
2.61e-108 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 322.94 E-value: 2.61e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 1 MKKRLQKIVFVFLASLLAAgtfqlpkkayAQDDINVHAKAAILVEASTGKILYKKNADQALGIASMSKMMTEYILLKAIK 80
Cdd:COG1686 1 MKKLLLLALLLLLAAAAAA----------PAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 81 EKKVSWDQKVTISDYAYKIsqnrDLSNVPLRQGGKYTLKELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQAKAFG 160
Cdd:COG1686 71 AGKISLDDKVTVSEEAART----GGSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 161 LTHYKFVNSSGLNNadlqgmqpdrgdatEENAMSARSAAKVAYHLVNDFPEMLKTSSIPEKKFRPGTKdeIDMKNWNWML 240
Cdd:COG1686 147 MTNTHFVNPTGLPD--------------PGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNGRG--ITLRNTNRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 241 pslvYGKEGVDGLKTGTTDYAGYCFTGTAEQNGMRVITVVLHATnaqgkgGYKARFDETSKLMDYAFnnysmktlyPKGY 320
Cdd:COG1686 211 ----GRYPGVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAP------SEKARFADAAKLLDYGF---------PKGE 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 321 SVKNKKTItvkagkekqapivteaplkapikngeshmytpvvkleKQQINAPVKKGTSVGTLLAKhKGGQEPGylygpds 400
Cdd:COG1686 272 ALKAEVVL-------------------------------------DGPLKAPVKKGQVVGTLVVT-LDGKTIA------- 306
|
410
....*....|....*..
gi 517494710 401 pHVDVVVKNGVEKANWF 417
Cdd:COG1686 307 -EVPLVAAEDVEKAGFF 322
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
36-283 |
4.63e-80 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 247.30 E-value: 4.63e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 36 VHAKAAILVEASTGKILYKKNADQALGIASMSKMMTEYILLKAIKEKKVSWDQKVTISDYAYKISQNrDLSNVPLRQGGK 115
Cdd:pfam00768 6 IAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP-GSSNIFLKPGSQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 116 YTLKELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQAKAFGLTHYKFVNSSGLNNadlqgmqpdrgdatEENAMSA 195
Cdd:pfam00768 85 VSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDA--------------HGQYSSA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 196 RSAAKVAYHLVNDFPEMLKTSSIPEKKFRpgtkdeiDMKNWNWMLPSLVYGKEG--VDGLKTGTTDYAGYCFTGTAEQNG 273
Cdd:pfam00768 151 RDMAILAKALIKDLPEELSITKEKSFTFR-------GINKINQRNRNGLLWDKTwnVDGLKTGYTNEAGYCLVASATKGG 223
|
250
....*....|
gi 517494710 274 MRVITVVLHA 283
Cdd:pfam00768 224 MRLISVVMGA 233
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
39-331 |
7.54e-58 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 194.04 E-value: 7.54e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 39 KAAILVeASTGKILYKKNADQALGIASMSKMMTEYILLKAIKEKKVSWDQKVTISDYAYKISQNRDLSNVPLRQGGKYTL 118
Cdd:NF038258 41 EGAIVT-TQTGQILYDYHGNKKWDPASMTKLMTMYLTLEAIKKGKLSLNDKVKITSDYEKMSTLPNLSTFPLKPGQTYTI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 119 KELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQAKAFGLTHYKFVNSSGLNNADLQGMQPDRGDATEENAMSARSA 198
Cdd:NF038258 120 KELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKALGMKHTHFTNPSGADNNLLKPYAPKKYKDETKSKSTAKDM 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 199 AKVAYHLVNDFPEMLKTSsipekKFRPGTKDEIDMKNWNWMLPSLVYGKEGVDGLKTGTTDyAGYCFTGTAEQNGMRVIT 278
Cdd:NF038258 200 AILSQHLIKKHPKILKYT-----KLTADTQHGVTLYTTNLSLPGQPMSLKGTDGLKTGTSD-EGYNLALTTKRDGLRINQ 273
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 517494710 279 VVLHATNAQGKGGYKARFDETSKLMDYAFNNYSMKTLYPKGYSVKNKKTITVK 331
Cdd:NF038258 274 VIMNVGPYPSEGAKHARNKIANALMERAFKQYEYKKVLSKGEHKIDGKTYYVK 326
|
|
| PRK10001 |
PRK10001 |
serine-type D-Ala-D-Ala carboxypeptidase; |
10-440 |
2.07e-43 |
|
serine-type D-Ala-D-Ala carboxypeptidase;
Pssm-ID: 182189 [Multi-domain] Cd Length: 400 Bit Score: 157.08 E-value: 2.07e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 10 FVFLASLLAAGT---FQLPKKAYAQDDI----NVHAKAAILVEASTGKILYKKNADQALGIASMSKMMTEYILLKAIKEK 82
Cdd:PRK10001 4 YSSLLRGLAAGSaflFLFAPTAFAAEQTveapSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKAD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 83 KVSWDQKVTISDYAYKISQN--RDLSNVPLRQGGKYTLKELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQAKAFG 160
Cdd:PRK10001 84 KIKLTDMVTVGKDAWATGNPalRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 161 LTHYKFVNSSGLnnadlqgmqpdrgDATEENAmSARSAAKVAYHLVNDFPEMLKTSSipEKKFrpgTKDEIDMKNWNWML 240
Cdd:PRK10001 164 LTNTTFQTVHGL-------------DAPGQFS-TARDMALLGKALIHDVPEEYAIHK--EKEF---TFNKIRQPNRNRLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 241 PSlvyGKEGVDGLKTGTTDYAGYCFTGTAEQNGMRVITVVLHATNAqgkggyKARFDETSKLMDYAFNNYSMKT-LYPKG 319
Cdd:PRK10001 225 WS---SNLNVDGMKTGTTAGAGYNLVASATQGDMRLISVVLGAKTD------RIRFNESEKLLTWGFRFFETVTpIKPDA 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 320 YSVK------NKKTITVKAGKEKQAPIvteaPlKAPIKNGESHmYTpvvkLEKQQINAPVKKGTSVGTLLAKHKGgqepg 393
Cdd:PRK10001 296 TFVTqrvwfgDKSEVNLGAGEAGSVTI----P-RGQLKNLKAS-YT----LTEPQLTAPLKKGQVVGTIDFQLNG----- 360
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 517494710 394 ylygpdsphvdvvvkNGVEKANWFVMMMRGIGGFFSGIWSHTV-------GSWF 440
Cdd:PRK10001 361 ---------------KSIEQRPLIVMENVEEGGFFSRMWDFVMmkfhqwfGSWF 399
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
310-413 |
1.96e-13 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 65.70 E-value: 1.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 310 YSMKTLYPKGYSVKnkkTITVKAGKEKQAPIVTEAPLKAPIKNGESHMYTPVVKLEKQQINAPVKKGTSVGTLLAKhKGG 389
Cdd:smart00936 1 FETVKLYKKGQVVG---TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVT-LDG 76
|
90 100
....*....|....*....|....
gi 517494710 390 QEPGylygpdspHVDVVVKNGVEK 413
Cdd:smart00936 77 KLIG--------EVPLVALEDVEK 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| strep_PBP3 |
NF038273 |
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ... |
12-416 |
1.59e-134 |
|
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.
Pssm-ID: 468443 [Multi-domain] Cd Length: 407 Bit Score: 392.70 E-value: 1.59e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 12 FLASLLAAGTFQLPKKAYAqDDINVHAKAAILVEASTGKILYKKNADQALGIASMSKMMTEYILLKAIKEKKVSWDQKVT 91
Cdd:NF038273 3 LILLLLLLLAFFLATTVSA-DDFDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGKLSWDTPVK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 92 ISDYAYKISQNRDLSNVPLrQGGKYTLKELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQAKAFGLTHYKFVNSSG 171
Cdd:NF038273 82 ISDYPYELTTNYEISNVPL-DARKYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITDAKLVNASG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 172 LNNADLqgmqpdrGD-------ATEENAMSARSAAKVAYHLVNDFPEMLKTSSIPEKKFrpgtkDEIDMKNWNWMLPSLV 244
Cdd:NF038273 161 LNNSYL-------GDhiypgskKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADF-----AGTTIYSYNYMLKGMP 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 245 YGKEGVDGLKTGTTDYAGYCFTGTAEQNGMRVITVVLHATNAQGKGgyKARFDETSKLMDYAFNNYSMKTLYPKGYSVKN 324
Cdd:NF038273 229 YYREGVDGLKTGTTEKAGASFVATSVENGMRVITVVLNADNADEDE--YARFTATNQLLDYIYQNFEKVTLVKKGQAYKD 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 325 KKtITVKAGKEKQAPIVTEAPLKAPIKNGESHMYTPVVKLEKQQINAPVKKGTSVGTLLAKHKGGQEPGYLYGPdsPHVD 404
Cdd:NF038273 307 SK-LPVIDGKKKTVSAVAKKDLTVIQKIGTDSKPSVKFTPKKKELTAPIKKGQVVGKATFKDKDLIGKGYLGEP--PSVE 383
|
410
....*....|..
gi 517494710 405 VVVKNGVEKANW 416
Cdd:NF038273 384 LVAKKDVKKSFF 395
|
|
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
1-417 |
2.61e-108 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 322.94 E-value: 2.61e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 1 MKKRLQKIVFVFLASLLAAgtfqlpkkayAQDDINVHAKAAILVEASTGKILYKKNADQALGIASMSKMMTEYILLKAIK 80
Cdd:COG1686 1 MKKLLLLALLLLLAAAAAA----------PAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 81 EKKVSWDQKVTISDYAYKIsqnrDLSNVPLRQGGKYTLKELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQAKAFG 160
Cdd:COG1686 71 AGKISLDDKVTVSEEAART----GGSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 161 LTHYKFVNSSGLNNadlqgmqpdrgdatEENAMSARSAAKVAYHLVNDFPEMLKTSSIPEKKFRPGTKdeIDMKNWNWML 240
Cdd:COG1686 147 MTNTHFVNPTGLPD--------------PGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNGRG--ITLRNTNRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 241 pslvYGKEGVDGLKTGTTDYAGYCFTGTAEQNGMRVITVVLHATnaqgkgGYKARFDETSKLMDYAFnnysmktlyPKGY 320
Cdd:COG1686 211 ----GRYPGVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAP------SEKARFADAAKLLDYGF---------PKGE 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 321 SVKNKKTItvkagkekqapivteaplkapikngeshmytpvvkleKQQINAPVKKGTSVGTLLAKhKGGQEPGylygpds 400
Cdd:COG1686 272 ALKAEVVL-------------------------------------DGPLKAPVKKGQVVGTLVVT-LDGKTIA------- 306
|
410
....*....|....*..
gi 517494710 401 pHVDVVVKNGVEKANWF 417
Cdd:COG1686 307 -EVPLVAAEDVEKAGFF 322
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
36-283 |
4.63e-80 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 247.30 E-value: 4.63e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 36 VHAKAAILVEASTGKILYKKNADQALGIASMSKMMTEYILLKAIKEKKVSWDQKVTISDYAYKISQNrDLSNVPLRQGGK 115
Cdd:pfam00768 6 IAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP-GSSNIFLKPGSQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 116 YTLKELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQAKAFGLTHYKFVNSSGLNNadlqgmqpdrgdatEENAMSA 195
Cdd:pfam00768 85 VSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDA--------------HGQYSSA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 196 RSAAKVAYHLVNDFPEMLKTSSIPEKKFRpgtkdeiDMKNWNWMLPSLVYGKEG--VDGLKTGTTDYAGYCFTGTAEQNG 273
Cdd:pfam00768 151 RDMAILAKALIKDLPEELSITKEKSFTFR-------GINKINQRNRNGLLWDKTwnVDGLKTGYTNEAGYCLVASATKGG 223
|
250
....*....|
gi 517494710 274 MRVITVVLHA 283
Cdd:pfam00768 224 MRLISVVMGA 233
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
39-331 |
7.54e-58 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 194.04 E-value: 7.54e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 39 KAAILVeASTGKILYKKNADQALGIASMSKMMTEYILLKAIKEKKVSWDQKVTISDYAYKISQNRDLSNVPLRQGGKYTL 118
Cdd:NF038258 41 EGAIVT-TQTGQILYDYHGNKKWDPASMTKLMTMYLTLEAIKKGKLSLNDKVKITSDYEKMSTLPNLSTFPLKPGQTYTI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 119 KELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQAKAFGLTHYKFVNSSGLNNADLQGMQPDRGDATEENAMSARSA 198
Cdd:NF038258 120 KELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKALGMKHTHFTNPSGADNNLLKPYAPKKYKDETKSKSTAKDM 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 199 AKVAYHLVNDFPEMLKTSsipekKFRPGTKDEIDMKNWNWMLPSLVYGKEGVDGLKTGTTDyAGYCFTGTAEQNGMRVIT 278
Cdd:NF038258 200 AILSQHLIKKHPKILKYT-----KLTADTQHGVTLYTTNLSLPGQPMSLKGTDGLKTGTSD-EGYNLALTTKRDGLRINQ 273
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 517494710 279 VVLHATNAQGKGGYKARFDETSKLMDYAFNNYSMKTLYPKGYSVKNKKTITVK 331
Cdd:NF038258 274 VIMNVGPYPSEGAKHARNKIANALMERAFKQYEYKKVLSKGEHKIDGKTYYVK 326
|
|
| PRK10001 |
PRK10001 |
serine-type D-Ala-D-Ala carboxypeptidase; |
10-440 |
2.07e-43 |
|
serine-type D-Ala-D-Ala carboxypeptidase;
Pssm-ID: 182189 [Multi-domain] Cd Length: 400 Bit Score: 157.08 E-value: 2.07e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 10 FVFLASLLAAGT---FQLPKKAYAQDDI----NVHAKAAILVEASTGKILYKKNADQALGIASMSKMMTEYILLKAIKEK 82
Cdd:PRK10001 4 YSSLLRGLAAGSaflFLFAPTAFAAEQTveapSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKAD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 83 KVSWDQKVTISDYAYKISQN--RDLSNVPLRQGGKYTLKELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQAKAFG 160
Cdd:PRK10001 84 KIKLTDMVTVGKDAWATGNPalRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 161 LTHYKFVNSSGLnnadlqgmqpdrgDATEENAmSARSAAKVAYHLVNDFPEMLKTSSipEKKFrpgTKDEIDMKNWNWML 240
Cdd:PRK10001 164 LTNTTFQTVHGL-------------DAPGQFS-TARDMALLGKALIHDVPEEYAIHK--EKEF---TFNKIRQPNRNRLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 241 PSlvyGKEGVDGLKTGTTDYAGYCFTGTAEQNGMRVITVVLHATNAqgkggyKARFDETSKLMDYAFNNYSMKT-LYPKG 319
Cdd:PRK10001 225 WS---SNLNVDGMKTGTTAGAGYNLVASATQGDMRLISVVLGAKTD------RIRFNESEKLLTWGFRFFETVTpIKPDA 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 320 YSVK------NKKTITVKAGKEKQAPIvteaPlKAPIKNGESHmYTpvvkLEKQQINAPVKKGTSVGTLLAKHKGgqepg 393
Cdd:PRK10001 296 TFVTqrvwfgDKSEVNLGAGEAGSVTI----P-RGQLKNLKAS-YT----LTEPQLTAPLKKGQVVGTIDFQLNG----- 360
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 517494710 394 ylygpdsphvdvvvkNGVEKANWFVMMMRGIGGFFSGIWSHTV-------GSWF 440
Cdd:PRK10001 361 ---------------KSIEQRPLIVMENVEEGGFFSRMWDFVMmkfhqwfGSWF 399
|
|
| PRK10793 |
PRK10793 |
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional |
12-382 |
5.13e-30 |
|
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
Pssm-ID: 182736 [Multi-domain] Cd Length: 403 Bit Score: 120.34 E-value: 5.13e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 12 FLASLLAAGTFQLPKKAYAQ-DDIN----------VHAKAAILVEASTGKILYKKNADQALGIASMSKMMTEYILLKAIK 80
Cdd:PRK10793 9 IMKRLALTTALCTAFISAAHaDDLNiktmipgvpqIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 81 EKKVSWDQKVTISDYAYKISQN--RDLSNVPLRQGGKYTLKELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQAKA 158
Cdd:PRK10793 89 AGKFKETDLVTVGNDAWATGNPvfKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVNA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 159 FGLTHYKFVNSSGLnnadlqgmqpdrgDAtEENAMSARSAAKVAYHLVNDFPEmlKTSSIPEKKFrpgTKDEIDMKNWNW 238
Cdd:PRK10793 169 LGLKNTHFQTVHGL-------------DA-DGQYSSARDMALIGQALIRDVPN--EYAIYKEKEF---TFNGIRQLNRNG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 239 ML--PSLvygkeGVDGLKTGTTDYAGYCFTGTAEQNGMRVITVVLhatnaqGKGGYKARFDETSKLMDYAFNNYsmKTLY 316
Cdd:PRK10793 230 LLwdNSL-----NVDGIKTGHTDKAGYNLVASATEGQMRLISAVM------GGRTFKGRETESKKLLTWGFRFF--ETVN 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517494710 317 PkgysvknkktitVKAGKE-----------KQAPIVTEAPLKAPIKNGESHMYTPVVKLEKQQINAPVKKGTSVGTL 382
Cdd:PRK10793 297 P------------LKVGKEfasepvwfgdsDRASLGVDKDVYLTIPRGRMKDLKASYVLNTSELHAPLQKNQVVGTI 361
|
|
| dacD |
PRK11397 |
serine-type D-Ala-D-Ala carboxypeptidase DacD; |
1-380 |
1.55e-29 |
|
serine-type D-Ala-D-Ala carboxypeptidase DacD;
Pssm-ID: 183117 [Multi-domain] Cd Length: 388 Bit Score: 118.77 E-value: 1.55e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 1 MKKRLQKIVFVFLASLLAAgtfqlpkkaYAQDDIN-------VHAKAAILVEASTGKILYKKNADQALGIASMSKMMTEY 73
Cdd:PRK11397 1 LKRRLIIAASLFAFNLSSA---------FAAENIPfspqppaIDAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGY 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 74 ILLKAIKEKKVSWDQKVTISDYAYKISQN--RDLSNVPLRQGGKYTLKELYEAMAIYSANGATIAIAEALAGSESNFLNM 151
Cdd:PRK11397 72 VVDRAIDSHRITPDDIVTVGRDAWAKDNPvfVGSSLMFLKEGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEM 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 152 MDKQAKAFGLTHYKFVNSSGLnnadlqgmqpdrgDATEENAmSARSAAKVAYHLVNDFPEMLKTSSipEKKFrpgTKDEI 231
Cdd:PRK11397 152 MNNYVEKLHLKDTHFETVHGL-------------DAPGQHS-SAYDLAVLSRAIIHGEPEFYHMYS--EKSL---TWNGI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 232 DMKNWNwmlpSLVYGKE-GVDGLKTGTTDYAGYCFTGTAEQNGMRVITVVLHATNAQGkggykaRFDETSKLMDYAFNNY 310
Cdd:PRK11397 213 TQQNRN----GLLWDKTmNVDGLKTGHTSGAGFNLIASAVDGQRRLIAVVMGADSAKG------REEQARKLLRWGQQNF 282
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517494710 311 SMKTLYPKGYSVKNKKtitVKAGKEKQAPIVTE-----APLKAPIKNGESHmYTpvvkLEKQQINAPVKKGTSVG 380
Cdd:PRK11397 283 TTVQILHRGKKVGTER---IWYGDKENIALGTEqdfwmVLPKAEIPHIKAK-YV----LDGKELEAPISAHQRVG 349
|
|
| pbpG |
PRK11669 |
D-alanyl-D-alanine endopeptidase; Provisional |
1-283 |
1.72e-16 |
|
D-alanyl-D-alanine endopeptidase; Provisional
Pssm-ID: 236952 Cd Length: 306 Bit Score: 79.72 E-value: 1.72e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 1 MKKRLQKIVFVFL---ASLLAAGTFQLPKKAYAQDDINVHAKAAILVEASTGKILYKKNADQALGIASMSKMMTEYILLK 77
Cdd:PRK11669 1 MKFRVSLLSLLLLlagVPFAPQAVAKTAAATTASQPQEIASGSAMVVDLNTNKVIYSSNPDLVVPIASITKLMTAMVVLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 78 AikekKVSWDQKVTIsdyayKISQNRDLSNV--PLRQGGKYTLKELYEAMAIYSANGATIAIAEALAGSESNFLNMMDKQ 155
Cdd:PRK11669 81 A----KLPLDEKLKV-----DISQTPEMKGVysRVRLNSEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMNAK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 156 AKAFGLTHYKFVNSSGLnnadlqgmqpdrgdaTEENAMSARSAAK--VAYHlvnDFPEMLKTSSIPEKK----------- 222
Cdd:PRK11669 152 AKALGMTNTRYVEPTGL---------------SIHNVSTARDLTKllIASK---QYPLIGQLSTTREKTatfrkpnytlp 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517494710 223 FRpGTKDEIDMKNWNWMLPslvygkegvdglKTGTTDYAGYCFTGTAEQNGMRVITVVLHA 283
Cdd:PRK11669 214 FR-NTNHLVYRDNWNIQLT------------KTGFTNAAGHCLVMRTVINNRPVALVVLDA 261
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
310-413 |
1.96e-13 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 65.70 E-value: 1.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 310 YSMKTLYPKGYSVKnkkTITVKAGKEKQAPIVTEAPLKAPIKNGESHMYTPVVKLEKQQINAPVKKGTSVGTLLAKhKGG 389
Cdd:smart00936 1 FETVKLYKKGQVVG---TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVT-LDG 76
|
90 100
....*....|....*....|....
gi 517494710 390 QEPGylygpdspHVDVVVKNGVEK 413
Cdd:smart00936 77 KLIG--------EVPLVALEDVEK 92
|
|
| PBP5_C |
pfam07943 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
310-413 |
2.34e-10 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 429749 [Multi-domain] Cd Length: 91 Bit Score: 56.83 E-value: 2.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 310 YSMKTLYPKGYSVKNKKtitVKAGKEKQAPIVTEAPLKAPIKNGESHMYTPVVKLEKqQINAPVKKGTSVGTLLAKhKGG 389
Cdd:pfam07943 1 FETKKLYKKGDVVKKVK---VWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKVTLKK-PLEAPIKKGQVVGKLEVY-LDG 75
|
90 100
....*....|....*....|....
gi 517494710 390 QEPGYlygpdsphVDVVVKNGVEK 413
Cdd:pfam07943 76 KLIGE--------VPLVAKEDVEE 91
|
|
| PenP |
COG2367 |
Beta-lactamase class A [Defense mechanisms]; |
56-208 |
2.41e-07 |
|
Beta-lactamase class A [Defense mechanisms];
Pssm-ID: 441934 [Multi-domain] Cd Length: 276 Bit Score: 51.82 E-value: 2.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 56 NADQALGIASMSKMMTEYILLKAIKEKKVSWDQKVTISDyaykisqnRDLSN-----VPLRQGGKYTLKELYEAMAIYSA 130
Cdd:COG2367 51 NADERFPAASTFKLPVLAAVLRQVDAGKLSLDERVTLTP--------EDLVGgsgilQKLPDGTGLTLRELAELMITVSD 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517494710 131 NGATIAIAEALAGSESNflnmmdKQAKAFGLTHYKFVNssglNNADLQGMQPDRgdateENAMSARSAAKVAYHLVND 208
Cdd:COG2367 123 NTATNLLLRLLGPDAVN------AFLRSLGLTDTRLDR----KEPDLNELPGDG-----RNTTTPRDMARLLAALYRG 185
|
|
| Beta-lactamase2 |
pfam13354 |
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ... |
56-208 |
1.32e-06 |
|
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.
Pssm-ID: 463854 [Multi-domain] Cd Length: 215 Bit Score: 48.81 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517494710 56 NADQALGIASMSKMMTEYILLKAIKEKKVSWDQKVTISDyAYKISQNRDLSnvPLRQGGKYTLKELYEAMAIYSANGATI 135
Cdd:pfam13354 16 NGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTA-EDKVGGSGILQ--YLPDGSQLSLRDLLTLMIAVSDNTATN 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517494710 136 AIAEALAGSESNflnmmdkqakafglthyKFVNSSGLNNADLQGMQPDR--GDATEENAMSARSAAKVAYHLVND 208
Cdd:pfam13354 93 LLIDRLGLEAVN-----------------ARLRALGLRDTRLRRKLPDLraADKGGTNTTTARDMAKLLEALYRG 150
|
|
| AmpC |
COG1680 |
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms]; |
40-95 |
4.69e-03 |
|
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];
Pssm-ID: 441286 [Multi-domain] Cd Length: 355 Bit Score: 38.90 E-value: 4.69e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517494710 40 AAILVeASTGKILYKKN---ADQALG----------IASMSKMMTEYILLKAIKEKKVSWDQKVtiSDY 95
Cdd:COG1680 35 AAVAV-VRDGKVVYEKAygvADLETGrpvtpdtlfrIASVTKSFTATAVLQLVEEGKLDLDDPV--SKY 100
|
|
| |
