View
Concise Results
Standard Results
Full Results
Rne/Rng family ribonuclease [Acinetobacter tjernbergiae]
Protein Classification
ribonuclease E domain-containing protein ( domain architecture ID 1001066 )
ribonuclease E domain-containing protein similar to ribonuclease E (RNase E), a principal factor in RNA turnover and processing that helps to exercise fine control of gene expression in bacteria
List of domain hits
Name
Accession
Description
Interval
E-value
CafA
COG1530 Ribonuclease G or E [Translation, ribosomal structure and biogenesis];
2-484
0e+00
Ribonuclease G or E [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441139 [Multi-domain]
Cd Length: 490
Bit Score: 736.19
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 2 K RM LINAT HA E e V RVAL IT G N RL YDF D L E NRT REQ KKS NIYKG H VTRV E P S L E A V FV EY G AQ R Q GFL SMRE I ANS YF KAD 81
Cdd:COG1530 1 K EI LINAT PQ E - T RVAL VE G G RL VEL D I E RPG REQ LVG NIYKG K VTRV L P G L Q A A FV DI G LE R H GFL HVKD I SPE YF SLG 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 82 PRQTS --- NI RELIT EG T E L LVQV E KE E RG N KGA A L S TFISLAGRYLVLMPNN p KGG G I SR Q I S G SV - RE E LKE I L AS L N 157
Cdd:COG1530 80 KEDSG krp NI QDVLK EG Q E V LVQV V KE P RG T KGA R L T TFISLAGRYLVLMPNN - RHV G V SR R I E G EE e RE R LKE L L SE L K 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 158 I P R GM SV IVRTA GI G RTQ EELQ L DL QH LL D LW AQ IQ GS A S S GPS P M L VH QE AGVVT RA I RDY L R D D VA EIL I DS EQ AY NE 237
Cdd:COG1530 159 V P E GM GL IVRTA AE G ASE EELQ W DL DY LL K LW EA IQ EA A K S AKA P F L IY QE LDLII RA L RDY F R P D IG EIL V DS RE AY EK 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 238 A YN F VKA VMP RQL D KL K T YT LNE PLF AHFG IESQI QT A Y ER E V K L P SGG SI VIDQTEAL VS ID I NS AKS T R G HDV EETA L 317
Cdd:COG1530 239 A KD F ISL VMP DLA D RV K L YT GER PLF DRYQ IESQI ES A L ER R V W L K SGG YL VIDQTEAL TT ID V NS GRF T G G RNI EETA F 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 318 N TNLEAA E EIARQLRLRD I GG LV VIDFIDM TKDRN QR M VE AK L R EA TQS DRAR I Q F G QL SRFGL M EM S RQRLRPSL E E AT 397
Cdd:COG1530 319 K TNLEAA D EIARQLRLRD L GG II VIDFIDM EDEEH QR E VE NR L K EA LKK DRAR T Q I G GI SRFGL V EM T RQRLRPSL G E SL 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 398 GYV CPRC H G T G MVRDLRSLS L S I M R KV E EI A LR E RQG EV Q V EV P V E I AA F LLNEKR HS L VY LE QTSN V RVTVL P H P H LET 477
Cdd:COG1530 399 CEP CPRC E G R G TIKSVETVA L E I L R EI E RE A RK E NTR EV L V QA P P E V AA Y LLNEKR QE L AE LE KRYG V SIKLI P N P S LET 478
....*..
gi 517507172 478 PH Y Q I QF 484
Cdd:COG1530 479 EQ Y D I VR 485
rne super family
cl35953 ribonuclease E; Reviewed
1-1077
0e+00
ribonuclease E; Reviewed
PRK10811 :Pssm-ID: 236766 [Multi-domain]
Cd Length: 1068
Bit Score: 652.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 1 MKRMLINAT HA EE V RVAL IT G N RLYD F D L E NRTR EQKK S NIYKG HV TR V EPSLEA V FV E YGA Q R Q GFL SMR EIA NS YF K A 80
Cdd:PRK10811 1 MKRMLINAT QQ EE L RVAL VD G Q RLYD L D I E SPGH EQKK A NIYKG KI TR I EPSLEA A FV D YGA E R H GFL PLK EIA RE YF P A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 81 D -- PRQTS NI RELIT EG T E LL VQ VE KEERGNKGAAL S TFISLAG R YLVLMPNNP KG GGISR Q I S G SV R E ELKE I LASL NI 158
Cdd:PRK10811 81 N ys AHGRP NI KDVLR EG Q E VI VQ ID KEERGNKGAAL T TFISLAG S YLVLMPNNP RA GGISR R I E G DD R T ELKE A LASL EL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 159 P R GM SV IVRTAG I G RTQ E E LQ L DL QHL L DL W AQ I QGS A S S G P S P M L V HQE AG V VT RA I RDYLR D D VA EILID SEQAYNE A 238
Cdd:PRK10811 161 P E GM GL IVRTAG V G KSA E A LQ W DL SFR L KH W EA I KKA A E S R P A P F L I HQE SN V IV RA F RDYLR Q D IG EILID NPKVLEL A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 239 YNFVK A V - M P RQLD K L K T YT LNE PLF A H FG IESQI QT A YE REV K LPSGGSIVID Q TEAL VS IDINSA KS TRG H D V EETA L 317
Cdd:PRK10811 241 RQHIA A L g R P DFSS K I K L YT GEI PLF S H YQ IESQI ES A FQ REV R LPSGGSIVID S TEAL TA IDINSA RA TRG G D I EETA F 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 318 NTNLEAA E EIARQLRLRD I GGL V VIDFIDMT KD R N QR M VE AK LREA TQS DRARIQ FGQL SRFGL M EMSRQRL R PSL E E AT 397
Cdd:PRK10811 321 NTNLEAA D EIARQLRLRD L GGL I VIDFIDMT PV R H QR A VE NR LREA VRQ DRARIQ ISHI SRFGL L EMSRQRL S PSL G E SS 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 398 GY VCPRC H GTG M VRD LR SLSLSI M R KV EE I AL R E RQG EV QVE VPV E IA AF LLNEKR HSLVYL E - QTSN VR VTVL P HPHLE 476
Cdd:PRK10811 401 HH VCPRC S GTG T VRD NE SLSLSI L R LI EE E AL K E NTQ EV HAI VPV P IA SY LLNEKR SAVNAI E t RQGG VR CVIV P NDQMQ 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 477 TPHY qiqfnpdgfaps S YE R tea T R SS E K -- E L G Y ESSDW H L E EA ---- E HTH A APAQNNAA A QQKK A AQQQAAQ P KQTQ 550
Cdd:PRK10811 481 TPHY ------------ S VL R --- V R KG E E tp T L S Y MLPKL H E E AM alps E EEF A ERKRPEQP A LATF A MPDVPPA P TPAE 545
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 551 Q A VAQKS A S P cawlenlfvqkqaqttdqsrs AQN AA ASIE Q min N G AV SR g Q FG QVNVPVATT E AVA P VA nnayis Q SPV 630
Cdd:PRK10811 546 P A APVVA A A P --------------------- KAA AA TPPA Q --- P G LL SR - F FG ALKALFSGG E ETK P QE ------ Q PAP 594
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 631 K Q EA RESFEK D EKSH R P N QSQ ---------- N QKK R KHK E Q RE QH --- SHVHE QQ PNQVH E EIVQVPSRQEQPSRQE Q RE 697
Cdd:PRK10811 595 K A EA KPERQQ D RRKP R Q N NRR drnerrdtrd N RTR R EGR E N RE EN rrn RRQAQ QQ TAETR E SQQAEVTEKARTQDEQ Q QA 674
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 698 lkrqqkrqqpqehqsqqqhhdavhgnndstpl PRR D R nn Q Q R P N RPN R HRD Q SV l NETPIATEPAVNPQ Q VKVDVINA PR 777
Cdd:PRK10811 675 -------------------------------- PRR E R -- Q R R R N DEK R QAQ Q EA - KALNVEEQSVQETE Q EERVQQVQ PR 719
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 778 AEPMNTALI V N I - DQGQS E I VA LNAQQ T S A PAAK V EAA P VVVEKPETIEPVQTE Q AVV E VA EE VAVAEETAQAPVK R ASN 856
Cdd:PRK10811 720 RKQRQLNQK V R I e QSVAE E A VA PVVEE T V A AEPV V QEV P APRTELVKVPLPVVA Q TAP E QD EE NNAENRDNNGMPR R SRR 799
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 857 D PR ---- S RS R Q R ---------------- S A QTA P KT A VP K I ------- A P SQIPTLG Q ytlgslirhvyg EDCTILIE Q 909
Cdd:PRK10811 800 S PR hlrv S GQ R R R ryrderyptqspmplt V A CAS P EM A SG K V wirypvv R P QDVQVEE Q ------------ REAEEVQV Q 867
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 910 FGLVTTFNR A LQKF V EQYASSLVTTTEE E KRP V TRDVELPNQKQT E EAE P AAVL A LTPPEATA I RVANDP rerrrlakl A 989
Cdd:PRK10811 868 PVVAEVPVA A AVEP V VSAPVVEAVAEVV E EPV V VAEPQPEEVVVV E TTH P EVIA A PVTEQPQV I TESDVA --------- V 938
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 990 A EQAK E AHIA V S E EAPSPTEA E TTVTIE skv E EA V V E QT V K A EE A IVAT A PEQQPL E LT T VESSAITVVESET A VS E V N L 1069
Cdd:PRK10811 939 A QEVA E HAEP V V E PQDETADI E EAAETA --- E VV V A E PE V V A QP A APVV A EVAAEV E TV T AVEPEVAPAQVPE A TV E H N H 1015
....*...
gi 517507172 1070 SSV P EAT A 1077
Cdd:PRK10811 1016 ATA P MTR A 1023
Name
Accession
Description
Interval
E-value
CafA
COG1530 Ribonuclease G or E [Translation, ribosomal structure and biogenesis];
2-484
0e+00
Ribonuclease G or E [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441139 [Multi-domain]
Cd Length: 490
Bit Score: 736.19
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 2 K RM LINAT HA E e V RVAL IT G N RL YDF D L E NRT REQ KKS NIYKG H VTRV E P S L E A V FV EY G AQ R Q GFL SMRE I ANS YF KAD 81
Cdd:COG1530 1 K EI LINAT PQ E - T RVAL VE G G RL VEL D I E RPG REQ LVG NIYKG K VTRV L P G L Q A A FV DI G LE R H GFL HVKD I SPE YF SLG 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 82 PRQTS --- NI RELIT EG T E L LVQV E KE E RG N KGA A L S TFISLAGRYLVLMPNN p KGG G I SR Q I S G SV - RE E LKE I L AS L N 157
Cdd:COG1530 80 KEDSG krp NI QDVLK EG Q E V LVQV V KE P RG T KGA R L T TFISLAGRYLVLMPNN - RHV G V SR R I E G EE e RE R LKE L L SE L K 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 158 I P R GM SV IVRTA GI G RTQ EELQ L DL QH LL D LW AQ IQ GS A S S GPS P M L VH QE AGVVT RA I RDY L R D D VA EIL I DS EQ AY NE 237
Cdd:COG1530 159 V P E GM GL IVRTA AE G ASE EELQ W DL DY LL K LW EA IQ EA A K S AKA P F L IY QE LDLII RA L RDY F R P D IG EIL V DS RE AY EK 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 238 A YN F VKA VMP RQL D KL K T YT LNE PLF AHFG IESQI QT A Y ER E V K L P SGG SI VIDQTEAL VS ID I NS AKS T R G HDV EETA L 317
Cdd:COG1530 239 A KD F ISL VMP DLA D RV K L YT GER PLF DRYQ IESQI ES A L ER R V W L K SGG YL VIDQTEAL TT ID V NS GRF T G G RNI EETA F 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 318 N TNLEAA E EIARQLRLRD I GG LV VIDFIDM TKDRN QR M VE AK L R EA TQS DRAR I Q F G QL SRFGL M EM S RQRLRPSL E E AT 397
Cdd:COG1530 319 K TNLEAA D EIARQLRLRD L GG II VIDFIDM EDEEH QR E VE NR L K EA LKK DRAR T Q I G GI SRFGL V EM T RQRLRPSL G E SL 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 398 GYV CPRC H G T G MVRDLRSLS L S I M R KV E EI A LR E RQG EV Q V EV P V E I AA F LLNEKR HS L VY LE QTSN V RVTVL P H P H LET 477
Cdd:COG1530 399 CEP CPRC E G R G TIKSVETVA L E I L R EI E RE A RK E NTR EV L V QA P P E V AA Y LLNEKR QE L AE LE KRYG V SIKLI P N P S LET 478
....*..
gi 517507172 478 PH Y Q I QF 484
Cdd:COG1530 479 EQ Y D I VR 485
rne
PRK10811 ribonuclease E; Reviewed
1-1077
0e+00
ribonuclease E; Reviewed
Pssm-ID: 236766 [Multi-domain]
Cd Length: 1068
Bit Score: 652.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 1 MKRMLINAT HA EE V RVAL IT G N RLYD F D L E NRTR EQKK S NIYKG HV TR V EPSLEA V FV E YGA Q R Q GFL SMR EIA NS YF K A 80
Cdd:PRK10811 1 MKRMLINAT QQ EE L RVAL VD G Q RLYD L D I E SPGH EQKK A NIYKG KI TR I EPSLEA A FV D YGA E R H GFL PLK EIA RE YF P A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 81 D -- PRQTS NI RELIT EG T E LL VQ VE KEERGNKGAAL S TFISLAG R YLVLMPNNP KG GGISR Q I S G SV R E ELKE I LASL NI 158
Cdd:PRK10811 81 N ys AHGRP NI KDVLR EG Q E VI VQ ID KEERGNKGAAL T TFISLAG S YLVLMPNNP RA GGISR R I E G DD R T ELKE A LASL EL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 159 P R GM SV IVRTAG I G RTQ E E LQ L DL QHL L DL W AQ I QGS A S S G P S P M L V HQE AG V VT RA I RDYLR D D VA EILID SEQAYNE A 238
Cdd:PRK10811 161 P E GM GL IVRTAG V G KSA E A LQ W DL SFR L KH W EA I KKA A E S R P A P F L I HQE SN V IV RA F RDYLR Q D IG EILID NPKVLEL A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 239 YNFVK A V - M P RQLD K L K T YT LNE PLF A H FG IESQI QT A YE REV K LPSGGSIVID Q TEAL VS IDINSA KS TRG H D V EETA L 317
Cdd:PRK10811 241 RQHIA A L g R P DFSS K I K L YT GEI PLF S H YQ IESQI ES A FQ REV R LPSGGSIVID S TEAL TA IDINSA RA TRG G D I EETA F 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 318 NTNLEAA E EIARQLRLRD I GGL V VIDFIDMT KD R N QR M VE AK LREA TQS DRARIQ FGQL SRFGL M EMSRQRL R PSL E E AT 397
Cdd:PRK10811 321 NTNLEAA D EIARQLRLRD L GGL I VIDFIDMT PV R H QR A VE NR LREA VRQ DRARIQ ISHI SRFGL L EMSRQRL S PSL G E SS 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 398 GY VCPRC H GTG M VRD LR SLSLSI M R KV EE I AL R E RQG EV QVE VPV E IA AF LLNEKR HSLVYL E - QTSN VR VTVL P HPHLE 476
Cdd:PRK10811 401 HH VCPRC S GTG T VRD NE SLSLSI L R LI EE E AL K E NTQ EV HAI VPV P IA SY LLNEKR SAVNAI E t RQGG VR CVIV P NDQMQ 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 477 TPHY qiqfnpdgfaps S YE R tea T R SS E K -- E L G Y ESSDW H L E EA ---- E HTH A APAQNNAA A QQKK A AQQQAAQ P KQTQ 550
Cdd:PRK10811 481 TPHY ------------ S VL R --- V R KG E E tp T L S Y MLPKL H E E AM alps E EEF A ERKRPEQP A LATF A MPDVPPA P TPAE 545
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 551 Q A VAQKS A S P cawlenlfvqkqaqttdqsrs AQN AA ASIE Q min N G AV SR g Q FG QVNVPVATT E AVA P VA nnayis Q SPV 630
Cdd:PRK10811 546 P A APVVA A A P --------------------- KAA AA TPPA Q --- P G LL SR - F FG ALKALFSGG E ETK P QE ------ Q PAP 594
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 631 K Q EA RESFEK D EKSH R P N QSQ ---------- N QKK R KHK E Q RE QH --- SHVHE QQ PNQVH E EIVQVPSRQEQPSRQE Q RE 697
Cdd:PRK10811 595 K A EA KPERQQ D RRKP R Q N NRR drnerrdtrd N RTR R EGR E N RE EN rrn RRQAQ QQ TAETR E SQQAEVTEKARTQDEQ Q QA 674
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 698 lkrqqkrqqpqehqsqqqhhdavhgnndstpl PRR D R nn Q Q R P N RPN R HRD Q SV l NETPIATEPAVNPQ Q VKVDVINA PR 777
Cdd:PRK10811 675 -------------------------------- PRR E R -- Q R R R N DEK R QAQ Q EA - KALNVEEQSVQETE Q EERVQQVQ PR 719
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 778 AEPMNTALI V N I - DQGQS E I VA LNAQQ T S A PAAK V EAA P VVVEKPETIEPVQTE Q AVV E VA EE VAVAEETAQAPVK R ASN 856
Cdd:PRK10811 720 RKQRQLNQK V R I e QSVAE E A VA PVVEE T V A AEPV V QEV P APRTELVKVPLPVVA Q TAP E QD EE NNAENRDNNGMPR R SRR 799
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 857 D PR ---- S RS R Q R ---------------- S A QTA P KT A VP K I ------- A P SQIPTLG Q ytlgslirhvyg EDCTILIE Q 909
Cdd:PRK10811 800 S PR hlrv S GQ R R R ryrderyptqspmplt V A CAS P EM A SG K V wirypvv R P QDVQVEE Q ------------ REAEEVQV Q 867
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 910 FGLVTTFNR A LQKF V EQYASSLVTTTEE E KRP V TRDVELPNQKQT E EAE P AAVL A LTPPEATA I RVANDP rerrrlakl A 989
Cdd:PRK10811 868 PVVAEVPVA A AVEP V VSAPVVEAVAEVV E EPV V VAEPQPEEVVVV E TTH P EVIA A PVTEQPQV I TESDVA --------- V 938
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 990 A EQAK E AHIA V S E EAPSPTEA E TTVTIE skv E EA V V E QT V K A EE A IVAT A PEQQPL E LT T VESSAITVVESET A VS E V N L 1069
Cdd:PRK10811 939 A QEVA E HAEP V V E PQDETADI E EAAETA --- E VV V A E PE V V A QP A APVV A EVAAEV E TV T AVEPEVAPAQVPE A TV E H N H 1015
....*...
gi 517507172 1070 SSV P EAT A 1077
Cdd:PRK10811 1016 ATA P MTR A 1023
RNaseEG
TIGR00757 ribonuclease, Rne/Rng family; This model describes ribonuclease G (formerly CafA, cytoplasmic ...
15-422
1.66e-176
ribonuclease, Rne/Rng family; This model describes ribonuclease G (formerly CafA, cytoplasmic axial filament protein A), the N-terminal domain of ribonuclease E in which ribonuclease activity resides, and related proteins. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5' end of 16S RNA. The C-terminal half of RNase E (excluded from the seed alignment for this model) lacks ribonuclease activity but participates in mRNA degradation by organizing the degradosome. [Transcription, Degradation of RNA]
Pssm-ID: 273254 [Multi-domain]
Cd Length: 414
Bit Score: 523.81
E-value: 1.66e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 15 RVAL IT G N RL Y D FDL E NRTRE Q K K S NIYKG H VTR VE PSL E A V FV EY G AQRQ GFL SMRE I ANS Y FKAD P RQTS ----- N I R 89
Cdd:TIGR00757 2 RVAL VE G G RL F D LII E RPKSR Q L K G NIYKG R VTR IL PSL Q A A FV DI G LEKN GFL HASD I GPN Y ECLA P AEAK reagp S I S 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 90 EL ITE G TEL LVQV E KE E RGNKGA A L S T F ISL A GRYLVLMPNN P k GG G I SR Q I - SG SV RE E LK EI L A S LNI P R GM SV I V RT 168
Cdd:TIGR00757 82 EL LRP G QSV LVQV V KE P RGNKGA R L T T D ISL P GRYLVLMPNN S - HV G V SR R I e SG EE RE R LK KL L R S EEL P E GM GL I I RT 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 169 A GI G RTQ E E L QL DL QH LL DL W AQ I QGS A SSG P S P M L VHQ E AGVVT R A IRDYL RD DV A EILIDS EQA Y N EA YN F VKAVM P R 248
Cdd:TIGR00757 161 A AE G ASE E A L IK DL EF LL RK W EK I KEK A QKR P A P C L IYG E PDIIK R V IRDYL DT DV K EILIDS KEI Y E EA KE F IQLYA P E 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 249 QLD KLK T Y TLNE PLF AH F G IE S QI QT A YE R E V K LPSGG S IVIDQTEAL VS ID I NS AKS T R G HDV EETALNTNLEAA E EIA 328
Cdd:TIGR00757 241 LVS KLK L Y RGSD PLF EG F Q IE K QI DK A TQ R K V W LPSGG Y IVIDQTEAL TT ID V NS GRF T G G GNL EETALNTNLEAA K EIA 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 329 RQLRLR DI GG LVV IDFIDM TKDR NQR M V EAK L R EA TQS DRARIQ FGQL S R FGL M EM S R Q RLR P SL E E AT G Y VCP R C H GTG 408
Cdd:TIGR00757 321 RQLRLR NL GG III IDFIDM KSEK NQR R V LER L K EA LRR DRARIQ ISGI S E FGL V EM T R K RLR E SL M E VL G T VCP H C S GTG 400
410
....*....|....
gi 517507172 409 M V RDLR S LS L S I M R 422
Cdd:TIGR00757 401 I V KTSE S VL L E I E R 414
RNase_E_G
pfam10150 Ribonuclease E/G family; Ribonuclease E and Ribonuclease G are related enzymes that cleave a ...
120-387
5.55e-123
Ribonuclease E/G family; Ribonuclease E and Ribonuclease G are related enzymes that cleave a wide variety of RNAs.
Pssm-ID: 462965
Cd Length: 267
Bit Score: 378.27
E-value: 5.55e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 120 L A GRYLVLMP NN p K GG G I SR Q I SG - SV RE E LKEIL A SL N i P R GM S VIVRTA GI G RTQ EELQ L DL QH LL D LW AQ I QGS A SS 198
Cdd:pfam10150 1 L P GRYLVLMP FG - K IV G V SR K I ED e EE RE R LKEIL E SL K - P E GM G VIVRTA AE G ASE EELQ A DL EY LL K LW EE I LKK A KK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 199 GPS P M L VHQ E AGVVT R AI RD Y L R DD VA EI LI D S E QA Y N E AYN F VKAVM P RQLDKLKT Y TLNE PLF AHF GIE S QI QT A YE R 278
Cdd:pfam10150 79 AKA P S L LYE E LDLIL R VL RD L L N DD ID EI IV D D E EV Y E E IKE F LEEIA P DLKKRVEL Y EGER PLF DLY GIE K QI EK A LS R 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 279 E V K L P SGG SI VIDQTEAL VS ID I NS A K S T RGHDV EETAL N TNLEAA E EIARQLRLR DI GG LV VIDFIDM TKDR N QRM V EA 358
Cdd:pfam10150 159 K V W L K SGG YL VIDQTEAL TV ID V NS G K F T GKKNL EETAL K TNLEAA K EIARQLRLR NL GG II VIDFIDM KDEE N REK V LE 238
250 260
....*....|....*....|....*....
gi 517507172 359 K L R EA TQS DRA RI Q FGQLSRF GL M EM S R Q 387
Cdd:pfam10150 239 A L K EA LKK DRA KT Q VLGITKL GL V EM T R K 267
PRK11712
PRK11712 ribonuclease G; Provisional
4-460
2.18e-96
ribonuclease G; Provisional
Pssm-ID: 183285 [Multi-domain]
Cd Length: 489
Bit Score: 315.80
E-value: 2.18e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 4 M L I N A T HA E e V RVALI T G NR L YDFDL E NRTREQKKS NIYKG H V T RV E P SLE A V FV EY G AQRQG FL SMRE I A - NSYFK A DP 82
Cdd:PRK11712 5 L L V N V T PS E - T RVALI E G GI L QEIHI E REAKRGIVG NIYKG R V S RV L P GMQ A A FV DI G LDKAA FL HASD I V p HTECV A GE 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 83 R Q TS ---- N I R EL ITE G TELL VQV E K EER G N KGA A L S T F I S L AG RYLV L MP NNPKG G g I S RQ I - S GSV RE E LK E I L A SLN 157
Cdd:PRK11712 84 E Q KQ fvvr D I S EL VRQ G QDIM VQV V K DPL G T KGA R L T T D I T L PS RYLV F MP GASHV G - V S QR I e S EEE RE R LK K I V A PYC 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 158 IPR G m SV I V RTA GI G RTQ EEL QL D LQH L LD LW AQIQGSASSGPSPMLVHQ E AGVVT R AI RD YLRDDVAE I LI DS EQA Y N E 237
Cdd:PRK11712 163 DEQ G - GF I I RTA AE G VGE EEL AQ D AAF L KR LW TKVMERKKRYQTRYQLYG E LALAQ R VL RD FVGAELDR I RV DS RLT Y E E 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 238 AYN F VKAVM P RQL DKL KT Y TLNE P L F AHFGI E SQ IQ T A Y ER E V K L P SGG SIV IDQTEA LVSI DIN SAKST r GH - DV EET A 316
Cdd:PRK11712 242 LKE F TSEYI P EMT DKL EH Y SGRQ P I F DLYDV E NE IQ R A L ER K V E L K SGG YLI IDQTEA MTTV DIN TGAFV - GH r NL EET I 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 317 L NTN L EA AEE IARQLRLR DI GG LVV IDFIDM TKDRNQ R M V EAK L RE A TQS DR ARIQFGQL S RF GL M EM S R Q R L R P SLE EA 396
Cdd:PRK11712 321 F NTN I EA TQA IARQLRLR NL GG III IDFIDM NNEDHR R R V LHS L EQ A LSK DR VKTNINGF S QL GL V EM T R K R T R E SLE HV 400
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517507172 397 TGYV CP R CHG T G M V RDLRSLSLS IMR KVEEIALRERQGEVQ V EVPVEI A AF L LN E KR H S L VY LE 460
Cdd:PRK11712 401 LCGE CP T CHG R G T V KTVETVCYE IMR EIVRVHHAYDSDRFL V YASPAV A EA L KG E ES H A L AE LE 464
S1_RNase_E
cd04453 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential ...
32-123
8.17e-29
S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and the maturation of tRNA, 10Sa RNA and the M1 precursor of RNase P. RNase E associates with PNPase (3' to 5' exonuclease), Rhl B (DEAD-box RNA helicase) and enolase (glycolytic enzyme) to form the RNA degradosome. RNase E tends to cut mRNA within single-stranded regions that are rich in A/U nucleotides. The N-terminal region of RNase E contains the catalytic site. Within the conserved N-terminal domain of RNAse E and RNase G, there is an S1-like subdomain, which is an ancient single-stranded RNA-binding domain. S1 domain is an RNA-binding module originally identified in the ribosomal protein S1. The S1 domain is required for RNA cleavage by RNase E. RNase G is paralogous to RNase E with an N-terminal catalytic domain that is highly homologous to that of RNase E. RNase G not only shares sequence similarity with RNase E, but also functionally overlaps with RNase E. In Escherichia coli, RNase G is involved in the maturation of the 5' end of the 16S rRNA. RNase G plays a secondary role in mRNA decay.
Pssm-ID: 239900 [Multi-domain]
Cd Length: 88
Bit Score: 110.76
E-value: 8.17e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 32 RT RE QKKS NIY K G H V TRVE P S L E A V FV EY G AQRQ GFL SMRE I ANS YFK ADP rqts N I RE L IT EG T E L LVQV E KE ER G N KG 111
Cdd:cd04453 1 PN RE PIVG NIY L G R V KKIV P G L Q A A FV DI G LGKN GFL HLSD I LPA YFK KHK ---- K I AK L LK EG Q E I LVQV V KE PI G T KG 76
90
....*....|..
gi 517507172 112 AA L S T F ISL A GR 123
Cdd:cd04453 77 PR L T T N ISL P GR 88
S1
smart00316 Ribosomal protein S1-like RNA-binding domain;
37-116
8.73e-06
Ribosomal protein S1-like RNA-binding domain;
Pssm-ID: 197648 [Multi-domain]
Cd Length: 72
Bit Score: 44.52
E-value: 8.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 37 KKSNIYK G H VT RVE P S le AV FV EY G AQRQ G FLSMR E IANSYF K adprqts NIR E LITE G T E LL V Q V EKEERGNKGAA LS T 116
Cdd:smart00316 1 EVGDVVE G T VT EIT P G -- GA FV DL G NGVE G LIPIS E LSDKRV K ------- DPE E VLKV G D E VK V K V LSVDEEKGRII LS L 71
Name
Accession
Description
Interval
E-value
CafA
COG1530 Ribonuclease G or E [Translation, ribosomal structure and biogenesis];
2-484
0e+00
Ribonuclease G or E [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441139 [Multi-domain]
Cd Length: 490
Bit Score: 736.19
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 2 K RM LINAT HA E e V RVAL IT G N RL YDF D L E NRT REQ KKS NIYKG H VTRV E P S L E A V FV EY G AQ R Q GFL SMRE I ANS YF KAD 81
Cdd:COG1530 1 K EI LINAT PQ E - T RVAL VE G G RL VEL D I E RPG REQ LVG NIYKG K VTRV L P G L Q A A FV DI G LE R H GFL HVKD I SPE YF SLG 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 82 PRQTS --- NI RELIT EG T E L LVQV E KE E RG N KGA A L S TFISLAGRYLVLMPNN p KGG G I SR Q I S G SV - RE E LKE I L AS L N 157
Cdd:COG1530 80 KEDSG krp NI QDVLK EG Q E V LVQV V KE P RG T KGA R L T TFISLAGRYLVLMPNN - RHV G V SR R I E G EE e RE R LKE L L SE L K 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 158 I P R GM SV IVRTA GI G RTQ EELQ L DL QH LL D LW AQ IQ GS A S S GPS P M L VH QE AGVVT RA I RDY L R D D VA EIL I DS EQ AY NE 237
Cdd:COG1530 159 V P E GM GL IVRTA AE G ASE EELQ W DL DY LL K LW EA IQ EA A K S AKA P F L IY QE LDLII RA L RDY F R P D IG EIL V DS RE AY EK 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 238 A YN F VKA VMP RQL D KL K T YT LNE PLF AHFG IESQI QT A Y ER E V K L P SGG SI VIDQTEAL VS ID I NS AKS T R G HDV EETA L 317
Cdd:COG1530 239 A KD F ISL VMP DLA D RV K L YT GER PLF DRYQ IESQI ES A L ER R V W L K SGG YL VIDQTEAL TT ID V NS GRF T G G RNI EETA F 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 318 N TNLEAA E EIARQLRLRD I GG LV VIDFIDM TKDRN QR M VE AK L R EA TQS DRAR I Q F G QL SRFGL M EM S RQRLRPSL E E AT 397
Cdd:COG1530 319 K TNLEAA D EIARQLRLRD L GG II VIDFIDM EDEEH QR E VE NR L K EA LKK DRAR T Q I G GI SRFGL V EM T RQRLRPSL G E SL 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 398 GYV CPRC H G T G MVRDLRSLS L S I M R KV E EI A LR E RQG EV Q V EV P V E I AA F LLNEKR HS L VY LE QTSN V RVTVL P H P H LET 477
Cdd:COG1530 399 CEP CPRC E G R G TIKSVETVA L E I L R EI E RE A RK E NTR EV L V QA P P E V AA Y LLNEKR QE L AE LE KRYG V SIKLI P N P S LET 478
....*..
gi 517507172 478 PH Y Q I QF 484
Cdd:COG1530 479 EQ Y D I VR 485
rne
PRK10811 ribonuclease E; Reviewed
1-1077
0e+00
ribonuclease E; Reviewed
Pssm-ID: 236766 [Multi-domain]
Cd Length: 1068
Bit Score: 652.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 1 MKRMLINAT HA EE V RVAL IT G N RLYD F D L E NRTR EQKK S NIYKG HV TR V EPSLEA V FV E YGA Q R Q GFL SMR EIA NS YF K A 80
Cdd:PRK10811 1 MKRMLINAT QQ EE L RVAL VD G Q RLYD L D I E SPGH EQKK A NIYKG KI TR I EPSLEA A FV D YGA E R H GFL PLK EIA RE YF P A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 81 D -- PRQTS NI RELIT EG T E LL VQ VE KEERGNKGAAL S TFISLAG R YLVLMPNNP KG GGISR Q I S G SV R E ELKE I LASL NI 158
Cdd:PRK10811 81 N ys AHGRP NI KDVLR EG Q E VI VQ ID KEERGNKGAAL T TFISLAG S YLVLMPNNP RA GGISR R I E G DD R T ELKE A LASL EL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 159 P R GM SV IVRTAG I G RTQ E E LQ L DL QHL L DL W AQ I QGS A S S G P S P M L V HQE AG V VT RA I RDYLR D D VA EILID SEQAYNE A 238
Cdd:PRK10811 161 P E GM GL IVRTAG V G KSA E A LQ W DL SFR L KH W EA I KKA A E S R P A P F L I HQE SN V IV RA F RDYLR Q D IG EILID NPKVLEL A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 239 YNFVK A V - M P RQLD K L K T YT LNE PLF A H FG IESQI QT A YE REV K LPSGGSIVID Q TEAL VS IDINSA KS TRG H D V EETA L 317
Cdd:PRK10811 241 RQHIA A L g R P DFSS K I K L YT GEI PLF S H YQ IESQI ES A FQ REV R LPSGGSIVID S TEAL TA IDINSA RA TRG G D I EETA F 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 318 NTNLEAA E EIARQLRLRD I GGL V VIDFIDMT KD R N QR M VE AK LREA TQS DRARIQ FGQL SRFGL M EMSRQRL R PSL E E AT 397
Cdd:PRK10811 321 NTNLEAA D EIARQLRLRD L GGL I VIDFIDMT PV R H QR A VE NR LREA VRQ DRARIQ ISHI SRFGL L EMSRQRL S PSL G E SS 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 398 GY VCPRC H GTG M VRD LR SLSLSI M R KV EE I AL R E RQG EV QVE VPV E IA AF LLNEKR HSLVYL E - QTSN VR VTVL P HPHLE 476
Cdd:PRK10811 401 HH VCPRC S GTG T VRD NE SLSLSI L R LI EE E AL K E NTQ EV HAI VPV P IA SY LLNEKR SAVNAI E t RQGG VR CVIV P NDQMQ 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 477 TPHY qiqfnpdgfaps S YE R tea T R SS E K -- E L G Y ESSDW H L E EA ---- E HTH A APAQNNAA A QQKK A AQQQAAQ P KQTQ 550
Cdd:PRK10811 481 TPHY ------------ S VL R --- V R KG E E tp T L S Y MLPKL H E E AM alps E EEF A ERKRPEQP A LATF A MPDVPPA P TPAE 545
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 551 Q A VAQKS A S P cawlenlfvqkqaqttdqsrs AQN AA ASIE Q min N G AV SR g Q FG QVNVPVATT E AVA P VA nnayis Q SPV 630
Cdd:PRK10811 546 P A APVVA A A P --------------------- KAA AA TPPA Q --- P G LL SR - F FG ALKALFSGG E ETK P QE ------ Q PAP 594
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 631 K Q EA RESFEK D EKSH R P N QSQ ---------- N QKK R KHK E Q RE QH --- SHVHE QQ PNQVH E EIVQVPSRQEQPSRQE Q RE 697
Cdd:PRK10811 595 K A EA KPERQQ D RRKP R Q N NRR drnerrdtrd N RTR R EGR E N RE EN rrn RRQAQ QQ TAETR E SQQAEVTEKARTQDEQ Q QA 674
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 698 lkrqqkrqqpqehqsqqqhhdavhgnndstpl PRR D R nn Q Q R P N RPN R HRD Q SV l NETPIATEPAVNPQ Q VKVDVINA PR 777
Cdd:PRK10811 675 -------------------------------- PRR E R -- Q R R R N DEK R QAQ Q EA - KALNVEEQSVQETE Q EERVQQVQ PR 719
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 778 AEPMNTALI V N I - DQGQS E I VA LNAQQ T S A PAAK V EAA P VVVEKPETIEPVQTE Q AVV E VA EE VAVAEETAQAPVK R ASN 856
Cdd:PRK10811 720 RKQRQLNQK V R I e QSVAE E A VA PVVEE T V A AEPV V QEV P APRTELVKVPLPVVA Q TAP E QD EE NNAENRDNNGMPR R SRR 799
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 857 D PR ---- S RS R Q R ---------------- S A QTA P KT A VP K I ------- A P SQIPTLG Q ytlgslirhvyg EDCTILIE Q 909
Cdd:PRK10811 800 S PR hlrv S GQ R R R ryrderyptqspmplt V A CAS P EM A SG K V wirypvv R P QDVQVEE Q ------------ REAEEVQV Q 867
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 910 FGLVTTFNR A LQKF V EQYASSLVTTTEE E KRP V TRDVELPNQKQT E EAE P AAVL A LTPPEATA I RVANDP rerrrlakl A 989
Cdd:PRK10811 868 PVVAEVPVA A AVEP V VSAPVVEAVAEVV E EPV V VAEPQPEEVVVV E TTH P EVIA A PVTEQPQV I TESDVA --------- V 938
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 990 A EQAK E AHIA V S E EAPSPTEA E TTVTIE skv E EA V V E QT V K A EE A IVAT A PEQQPL E LT T VESSAITVVESET A VS E V N L 1069
Cdd:PRK10811 939 A QEVA E HAEP V V E PQDETADI E EAAETA --- E VV V A E PE V V A QP A APVV A EVAAEV E TV T AVEPEVAPAQVPE A TV E H N H 1015
....*...
gi 517507172 1070 SSV P EAT A 1077
Cdd:PRK10811 1016 ATA P MTR A 1023
RNaseEG
TIGR00757 ribonuclease, Rne/Rng family; This model describes ribonuclease G (formerly CafA, cytoplasmic ...
15-422
1.66e-176
ribonuclease, Rne/Rng family; This model describes ribonuclease G (formerly CafA, cytoplasmic axial filament protein A), the N-terminal domain of ribonuclease E in which ribonuclease activity resides, and related proteins. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5' end of 16S RNA. The C-terminal half of RNase E (excluded from the seed alignment for this model) lacks ribonuclease activity but participates in mRNA degradation by organizing the degradosome. [Transcription, Degradation of RNA]
Pssm-ID: 273254 [Multi-domain]
Cd Length: 414
Bit Score: 523.81
E-value: 1.66e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 15 RVAL IT G N RL Y D FDL E NRTRE Q K K S NIYKG H VTR VE PSL E A V FV EY G AQRQ GFL SMRE I ANS Y FKAD P RQTS ----- N I R 89
Cdd:TIGR00757 2 RVAL VE G G RL F D LII E RPKSR Q L K G NIYKG R VTR IL PSL Q A A FV DI G LEKN GFL HASD I GPN Y ECLA P AEAK reagp S I S 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 90 EL ITE G TEL LVQV E KE E RGNKGA A L S T F ISL A GRYLVLMPNN P k GG G I SR Q I - SG SV RE E LK EI L A S LNI P R GM SV I V RT 168
Cdd:TIGR00757 82 EL LRP G QSV LVQV V KE P RGNKGA R L T T D ISL P GRYLVLMPNN S - HV G V SR R I e SG EE RE R LK KL L R S EEL P E GM GL I I RT 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 169 A GI G RTQ E E L QL DL QH LL DL W AQ I QGS A SSG P S P M L VHQ E AGVVT R A IRDYL RD DV A EILIDS EQA Y N EA YN F VKAVM P R 248
Cdd:TIGR00757 161 A AE G ASE E A L IK DL EF LL RK W EK I KEK A QKR P A P C L IYG E PDIIK R V IRDYL DT DV K EILIDS KEI Y E EA KE F IQLYA P E 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 249 QLD KLK T Y TLNE PLF AH F G IE S QI QT A YE R E V K LPSGG S IVIDQTEAL VS ID I NS AKS T R G HDV EETALNTNLEAA E EIA 328
Cdd:TIGR00757 241 LVS KLK L Y RGSD PLF EG F Q IE K QI DK A TQ R K V W LPSGG Y IVIDQTEAL TT ID V NS GRF T G G GNL EETALNTNLEAA K EIA 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 329 RQLRLR DI GG LVV IDFIDM TKDR NQR M V EAK L R EA TQS DRARIQ FGQL S R FGL M EM S R Q RLR P SL E E AT G Y VCP R C H GTG 408
Cdd:TIGR00757 321 RQLRLR NL GG III IDFIDM KSEK NQR R V LER L K EA LRR DRARIQ ISGI S E FGL V EM T R K RLR E SL M E VL G T VCP H C S GTG 400
410
....*....|....
gi 517507172 409 M V RDLR S LS L S I M R 422
Cdd:TIGR00757 401 I V KTSE S VL L E I E R 414
RNase_E_G
pfam10150 Ribonuclease E/G family; Ribonuclease E and Ribonuclease G are related enzymes that cleave a ...
120-387
5.55e-123
Ribonuclease E/G family; Ribonuclease E and Ribonuclease G are related enzymes that cleave a wide variety of RNAs.
Pssm-ID: 462965
Cd Length: 267
Bit Score: 378.27
E-value: 5.55e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 120 L A GRYLVLMP NN p K GG G I SR Q I SG - SV RE E LKEIL A SL N i P R GM S VIVRTA GI G RTQ EELQ L DL QH LL D LW AQ I QGS A SS 198
Cdd:pfam10150 1 L P GRYLVLMP FG - K IV G V SR K I ED e EE RE R LKEIL E SL K - P E GM G VIVRTA AE G ASE EELQ A DL EY LL K LW EE I LKK A KK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 199 GPS P M L VHQ E AGVVT R AI RD Y L R DD VA EI LI D S E QA Y N E AYN F VKAVM P RQLDKLKT Y TLNE PLF AHF GIE S QI QT A YE R 278
Cdd:pfam10150 79 AKA P S L LYE E LDLIL R VL RD L L N DD ID EI IV D D E EV Y E E IKE F LEEIA P DLKKRVEL Y EGER PLF DLY GIE K QI EK A LS R 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 279 E V K L P SGG SI VIDQTEAL VS ID I NS A K S T RGHDV EETAL N TNLEAA E EIARQLRLR DI GG LV VIDFIDM TKDR N QRM V EA 358
Cdd:pfam10150 159 K V W L K SGG YL VIDQTEAL TV ID V NS G K F T GKKNL EETAL K TNLEAA K EIARQLRLR NL GG II VIDFIDM KDEE N REK V LE 238
250 260
....*....|....*....|....*....
gi 517507172 359 K L R EA TQS DRA RI Q FGQLSRF GL M EM S R Q 387
Cdd:pfam10150 239 A L K EA LKK DRA KT Q VLGITKL GL V EM T R K 267
PRK11712
PRK11712 ribonuclease G; Provisional
4-460
2.18e-96
ribonuclease G; Provisional
Pssm-ID: 183285 [Multi-domain]
Cd Length: 489
Bit Score: 315.80
E-value: 2.18e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 4 M L I N A T HA E e V RVALI T G NR L YDFDL E NRTREQKKS NIYKG H V T RV E P SLE A V FV EY G AQRQG FL SMRE I A - NSYFK A DP 82
Cdd:PRK11712 5 L L V N V T PS E - T RVALI E G GI L QEIHI E REAKRGIVG NIYKG R V S RV L P GMQ A A FV DI G LDKAA FL HASD I V p HTECV A GE 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 83 R Q TS ---- N I R EL ITE G TELL VQV E K EER G N KGA A L S T F I S L AG RYLV L MP NNPKG G g I S RQ I - S GSV RE E LK E I L A SLN 157
Cdd:PRK11712 84 E Q KQ fvvr D I S EL VRQ G QDIM VQV V K DPL G T KGA R L T T D I T L PS RYLV F MP GASHV G - V S QR I e S EEE RE R LK K I V A PYC 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 158 IPR G m SV I V RTA GI G RTQ EEL QL D LQH L LD LW AQIQGSASSGPSPMLVHQ E AGVVT R AI RD YLRDDVAE I LI DS EQA Y N E 237
Cdd:PRK11712 163 DEQ G - GF I I RTA AE G VGE EEL AQ D AAF L KR LW TKVMERKKRYQTRYQLYG E LALAQ R VL RD FVGAELDR I RV DS RLT Y E E 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 238 AYN F VKAVM P RQL DKL KT Y TLNE P L F AHFGI E SQ IQ T A Y ER E V K L P SGG SIV IDQTEA LVSI DIN SAKST r GH - DV EET A 316
Cdd:PRK11712 242 LKE F TSEYI P EMT DKL EH Y SGRQ P I F DLYDV E NE IQ R A L ER K V E L K SGG YLI IDQTEA MTTV DIN TGAFV - GH r NL EET I 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 317 L NTN L EA AEE IARQLRLR DI GG LVV IDFIDM TKDRNQ R M V EAK L RE A TQS DR ARIQFGQL S RF GL M EM S R Q R L R P SLE EA 396
Cdd:PRK11712 321 F NTN I EA TQA IARQLRLR NL GG III IDFIDM NNEDHR R R V LHS L EQ A LSK DR VKTNINGF S QL GL V EM T R K R T R E SLE HV 400
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517507172 397 TGYV CP R CHG T G M V RDLRSLSLS IMR KVEEIALRERQGEVQ V EVPVEI A AF L LN E KR H S L VY LE 460
Cdd:PRK11712 401 LCGE CP T CHG R G T V KTVETVCYE IMR EIVRVHHAYDSDRFL V YASPAV A EA L KG E ES H A L AE LE 464
S1_RNase_E
cd04453 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential ...
32-123
8.17e-29
S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and the maturation of tRNA, 10Sa RNA and the M1 precursor of RNase P. RNase E associates with PNPase (3' to 5' exonuclease), Rhl B (DEAD-box RNA helicase) and enolase (glycolytic enzyme) to form the RNA degradosome. RNase E tends to cut mRNA within single-stranded regions that are rich in A/U nucleotides. The N-terminal region of RNase E contains the catalytic site. Within the conserved N-terminal domain of RNAse E and RNase G, there is an S1-like subdomain, which is an ancient single-stranded RNA-binding domain. S1 domain is an RNA-binding module originally identified in the ribosomal protein S1. The S1 domain is required for RNA cleavage by RNase E. RNase G is paralogous to RNase E with an N-terminal catalytic domain that is highly homologous to that of RNase E. RNase G not only shares sequence similarity with RNase E, but also functionally overlaps with RNase E. In Escherichia coli, RNase G is involved in the maturation of the 5' end of the 16S rRNA. RNase G plays a secondary role in mRNA decay.
Pssm-ID: 239900 [Multi-domain]
Cd Length: 88
Bit Score: 110.76
E-value: 8.17e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 32 RT RE QKKS NIY K G H V TRVE P S L E A V FV EY G AQRQ GFL SMRE I ANS YFK ADP rqts N I RE L IT EG T E L LVQV E KE ER G N KG 111
Cdd:cd04453 1 PN RE PIVG NIY L G R V KKIV P G L Q A A FV DI G LGKN GFL HLSD I LPA YFK KHK ---- K I AK L LK EG Q E I LVQV V KE PI G T KG 76
90
....*....|..
gi 517507172 112 AA L S T F ISL A GR 123
Cdd:cd04453 77 PR L T T N ISL P GR 88
S1
smart00316 Ribosomal protein S1-like RNA-binding domain;
37-116
8.73e-06
Ribosomal protein S1-like RNA-binding domain;
Pssm-ID: 197648 [Multi-domain]
Cd Length: 72
Bit Score: 44.52
E-value: 8.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 37 KKSNIYK G H VT RVE P S le AV FV EY G AQRQ G FLSMR E IANSYF K adprqts NIR E LITE G T E LL V Q V EKEERGNKGAA LS T 116
Cdd:smart00316 1 EVGDVVE G T VT EIT P G -- GA FV DL G NGVE G LIPIS E LSDKRV K ------- DPE E VLKV G D E VK V K V LSVDEEKGRII LS L 71
S1
pfam00575 S1 RNA binding domain; The S1 domain occurs in a wide range of RNA associated proteins. It is ...
37-116
3.60e-04
S1 RNA binding domain; The S1 domain occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure.
Pssm-ID: 425760 [Multi-domain]
Cd Length: 72
Bit Score: 39.96
E-value: 3.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517507172 37 K K SNIYK G H VTRV EP sl EAV FV EY G AQRQ GF LSMR E IAN syfkadp RQTSNIR E L I TE G T E LL V Q V E K EERGNKGAA LS T 116
Cdd:pfam00575 2 E K GDVVE G E VTRV TK -- GGA FV DL G NGVE GF IPIS E LSD ------- DHVEDPD E V I KV G D E VK V K V L K VDKDRRRII LS I 72
S1_like
cd00164 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of ...
42-115
7.92e-03
S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. Both domains are members of the Oligonucleotide/oligosaccharide Binding (OB) fold.
Pssm-ID: 238094 [Multi-domain]
Cd Length: 65
Bit Score: 36.20
E-value: 7.92e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517507172 42 YK G H V TRVEP sl EA VFVE YGAQRQ G FLSMR E IANSYF K adprqts NIR E LITE G T E LL V Q V EKEERGNKGAA LS 115
Cdd:cd00164 1 VT G K V VSITK -- FG VFVE LEDGVE G LVHIS E LSDKFV K ------- DPS E VFKV G D E VE V K V LEVDPEKGRIS LS 65
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
