|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
5-373 |
1.05e-71 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 228.59 E-value: 1.05e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 5 VFILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVM 84
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 85 TYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIA 164
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 165 FLSIISIILIYVFLENIPTEEVQP---ISVQIKSLGSVKMASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICY 241
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSlglLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 242 FLFGLSAVFGGAFGGTLADRIGSqKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAPPQQNYIIQIDPDA 321
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGR-RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 517537235 322 SDIQQSINNSALQIGISLGSAIGGVVLEHThSVISTAHVGAGVVVIALICGI 373
Cdd:cd17324 320 RGLASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLAL 370
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
3-378 |
2.36e-40 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 146.96 E-value: 2.36e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 3 FKVFILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGN 82
Cdd:PRK03545 9 LRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASH 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 83 VMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLG 162
Cdd:PRK03545 89 VLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 163 IAFLSIISIILIYVFLENIPTEevqpisvQIKSLGSVKM-------ASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQY 235
Cdd:PRK03545 169 IGGGALITLLLLIKLLPLLPSE-------HSGSLKSLPLlfrrpalVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSEN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 236 WISICYFLFGLSAVFGGAFGGTLADRiGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAPPQQNYII 315
Cdd:PRK03545 242 FATLLLLLFGGAGIIGSVLFSRLGNR-HPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517537235 316 QIDPDASDIQQSINNSALQIGISLGSAIGGVVLEHThSVISTAHVGAGVVVIALICGIISLTR 378
Cdd:PRK03545 321 KLAPDATDVAMALFSGIFNIGIGAGALLGNQVSLHL-GLSSIGYVGAALALAALVWSILIFRR 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-339 |
3.22e-40 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 145.89 E-value: 3.22e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 5 VFILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVM 84
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 85 TYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIA 164
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 165 FLSIISIILIYVFLENIPTEEVQPISVQIKSLGSVK-MASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFL 243
Cdd:COG2814 172 VLALLALLLLLRLLPESRPAARARLRGSLRELLRRPrLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 244 FGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTfSFPIFLVAMLLWGALSWSLAPPQQNYIIQIDPDAS- 322
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEAr 330
|
330
....*....|....*..
gi 517537235 323 DIQQSINNSALQIGISL 339
Cdd:COG2814 331 GRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-376 |
8.63e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 109.59 E-value: 8.63e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 8 LAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYF 87
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 88 SPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLS 167
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 168 IISIILIYVFL-ENIPTEEVQPISVQIKSLGSVKMASAH------LATMFMLAGHYTFYAYFTPFLETTLNMGQYWISIC 240
Cdd:cd17325 161 LLALVLALLLLpEPRPPPNKRAVSAARLRSGLRLLLRDRrllalfLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 241 YFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTfSFPIFLVAMLLWGALSWSLAPPQQNYIIQI-DP 319
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIvPP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 517537235 320 DASDIQQSINNSALQIGISLGSAIGGVVLEHTHsvISTAHVGAGVVVIALICGIISL 376
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG--FATPFLAAAALLLLAAVLFLLL 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
5-374 |
1.04e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 106.49 E-value: 1.04e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 5 VFILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVM 84
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 85 TYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIA 164
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 165 FLSIISIILIYVFLenipteevqpisvqikslgsvkmasaHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLF 244
Cdd:COG2271 172 LPGLLLALLRFWLL--------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 245 GLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTF-SFPIFLVAMLLWGALSWSLAPPQQNYIIQI-DPDAS 322
Cdd:COG2271 226 FLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLpSPALAIALLFLAGFGLGGAFGLLWALAAELfPKKAR 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 517537235 323 DIQQSINNSALQIGISLGSAIGGVVLEHTHSVISTAHVGAGVVVIALICGII 374
Cdd:COG2271 306 GTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
1-344 |
1.12e-25 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 106.72 E-value: 1.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 1 MNFKVFILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFL 80
Cdd:PRK10091 1 MKKVILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 81 GNVMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVF 160
Cdd:PRK10091 81 GNAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 161 LGIAFLSIISIILIYVFLENIPTEEVQPISVQIKSLGSVKMASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISIC 240
Cdd:PRK10091 161 LLIAVFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 241 YFLFGLSAVFGGAFGGTLADRIGSQK----SILLVISSFAIVLFLLPYSTFSfpifLVAMLLWGALSWSLAPPQQNYIIQ 316
Cdd:PRK10091 241 MMLVGLGMVLGNLLSGRLSGRYSPLRiaavTDFIIVLALLMLFFFGGMKTAS----LIFAFICCAGLFALSAPLQILLLQ 316
|
330 340
....*....|....*....|....*...
gi 517537235 317 IdpdaSDIQQSINNSALQIGISLGSAIG 344
Cdd:PRK10091 317 N----AKGGELLGAAGGQIAFNLGSAIG 340
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
5-370 |
1.19e-24 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 103.80 E-value: 1.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 5 VFILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVM 84
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 85 TYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDhFGWRTVFLGIA 164
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 165 FLSIISIILIYVFLENiPTEEVQPISVQIKSLGSVKMASAHLATMFMLA-----GHYTFYAYFTPFLETTLNMGQYWISI 239
Cdd:cd17474 160 ALIPVAFLAILFLLPE-PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAflyffLYFAFLTYLPFLLELLYGISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 240 CYFLFGLSAVFGGAFGGT-LADRIGSQKSILLVISSFAIVLFLLPYSTfSFPIFLVAMLLWGALSWSLAPPQQNYIIQID 318
Cdd:cd17474 239 LFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 517537235 319 PDAS-DIQQSINNSALQIGISLGSAIGGVVLEHTHSVISTAhVGAGVVVIALI 370
Cdd:cd17474 318 PEEErGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFL-VGAAIALAAAV 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
7-341 |
1.66e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.88 E-value: 1.66e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 7 ILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTY 86
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 87 FSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFL 166
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 167 SIISIILIYVFLENIPTEEVQPISVQIKSLGSVKMASAH------LATMFMLAGHYTFYAYFTPFLETTLNMGQYWISIC 240
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRdpvlwlLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 241 YFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPY--STFSFPIFLVAMLLWGALSWSLAPPQQNYIIQ-I 317
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLlsLTLSSLWLLLALLLLGFGFGLVFPALNALVSDlA 320
|
330 340
....*....|....*....|....
gi 517537235 318 DPDASDIQQSINNSALQIGISLGS 341
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-385 |
1.81e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 103.42 E-value: 1.81e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 7 ILAASTIAVGL---VELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNV 83
Cdd:COG2223 6 VLLLATLAFFLafgVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 84 MTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGI 163
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 164 AFLSIISIILIYVFLENIPTEEVQPISVQIKSLGSV-KMASAHLATMFMLA---GHYTFYAYFTPFLETTLNMGQYWISI 239
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEAlRDPRFWLLSLLYFGtfgSFIGFSSWLPPYLVDQFGLSAATAGL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 240 CYFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAPPQQNYIIQI-D 318
Cdd:COG2223 246 LAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIfP 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517537235 319 PDASDIQQSINNSALQIGISLGSAIGGVVLEHTHSVISTAHVGAGVVVIALICGIISLTRPYGVKQA 385
Cdd:COG2223 326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
8-348 |
1.73e-23 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 100.33 E-value: 1.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 8 LAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYF 87
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 88 SPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRtvflgiafls 167
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWR---------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 168 iisiiliYVFLENIPTEEVQPISVQIKSLGSvkmasahLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFGLS 247
Cdd:cd17321 151 -------WIFLINVPIGLVALLLARTFSGAV-------LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 248 AVFGGAFGGTLADRIGSQKSIL--LVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAPPQQNYII-QIDPDASDI 324
Cdd:cd17321 217 MLVAAPLAGRLADRFGPRLVLVagLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALsSVPKEKAGA 296
|
330 340
....*....|....*....|....
gi 517537235 325 QQSINNSALQIGISLGSAIGGVVL 348
Cdd:cd17321 297 ASGILNTARQLGGALGVALLGALL 320
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
8-373 |
4.72e-22 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 96.49 E-value: 4.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 8 LAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYF 87
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 88 SPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGiafls 167
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 168 iisiiliyvfleNIPTEEVQPISVQIKSLGSVKMASAHLATMFMLAGHYTFYA---YFTPFLETTLNMGQYWISICYFLF 244
Cdd:cd17503 156 ------------NLPIGILALLLAPLLDLRLFKDRNFTLGLLLSFLLGLGLFGamfLLPLYLQNVLGYSAFESGLVLAPG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 245 GLSAVFGGAFGGTLADRIGSQKSIL--LVISSFAIVLFLLPYSTFSFPIFLVAMLLWGA-LSWSLAPPQQNYIIQIDPDA 321
Cdd:cd17503 224 GLASAILSPLVGRLLDKFGPRLLLLagLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLgMGLVFMPLNTLALNSLPPEQ 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 517537235 322 SDIQQSINNSALQIGISLGSAIGGVVLE---HTHSVISTAHVGAGVVVIALICGI 373
Cdd:cd17503 304 IGDATALFNTIRQLGGSIGTALLATLLTnrtQFHHSRLSELLAQQVQKQALIIAF 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
25-370 |
3.08e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 85.34 E-value: 3.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 25 ILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMS 104
Cdd:cd17489 18 VLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 105 TALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLENIPTE 184
Cdd:cd17489 98 WGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 185 EVQPISVQIKSLGSVKMaSAHLATMFMLAGHYTFYAY--FTPFLETTLNMGQywISICYFLFGLSAVFGGAFGGTLADRI 262
Cdd:cd17489 178 AEEAEAGTRAFRRLVEK-KVLPPALILFLASIAYGAIstFLPLYAAERGISN--AGLFFTVYAIALLLSRPFSGKLSDRK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 263 GSQKSILLVISSFAIVLFLLPYSTfSFPIFLVAMLLWGALSWSLAPPQQNYIIQI-DPDASDIQQSINNSALQIGISLGS 341
Cdd:cd17489 255 GPKTVIIPGLLLLALGLLLLSFAG-SPWMLLLAAVLYGLGFGLLFPALQALAVDLvPPHRRGAANGTFFIFFDLGIGLGG 333
|
330 340
....*....|....*....|....*....
gi 517537235 342 AIGGVVLEHThSVISTAHVGAGVVVIALI 370
Cdd:cd17489 334 LLLGLVAELF-GYRAMFLLAAVVVLLALV 361
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
8-376 |
7.98e-18 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 84.17 E-value: 7.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 8 LAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYF 87
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 88 SPNFFIVMVARVITAMSTAlVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLS 167
Cdd:cd17504 81 APNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 168 IISIILIyvflenipteevqPIsVQIKSLGSVKMASAHLATMFMLAGHYTFYAYFTPFLE----TTLNMGQYWISICYFL 243
Cdd:cd17504 160 VLLAALV-------------PL-IDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 244 FGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAPPQQNYIIQ-IDPDAS 322
Cdd:cd17504 226 GALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVEsVPPDRT 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 517537235 323 DIQQSINNSALQIGISLGSAIGGVVLE--HTHSVISTAHVGAGVVVIALICGIISL 376
Cdd:cd17504 306 GIATGMNTVLRTIGSAIGPAIAGAILTtyTVSITSGGVPTEGAYVLAFLIGAALAL 361
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
26-373 |
1.75e-17 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 83.01 E-value: 1.75e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 26 LPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMST 105
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 106 ALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFL------E 179
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLpetlpeE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 180 NIPTEEVQPISVQIKSLGSVKMASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLA 259
Cdd:cd17320 182 KRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 260 DRIGSQKSILLVISSFAIVLFLLPYSTF-----SFPIFLVAMLLWGALSWSLaPPQQNYIIQIDPDASDIQQSINNSALQ 334
Cdd:cd17320 262 RRFGPRRLLRLGLLLLLAAALVLLLAALlgglsLWPLVAPLFLIFFGFGLIF-PNATSLALEPFPHVAGTASALLGFLQF 340
|
330 340 350
....*....|....*....|....*....|....*....
gi 517537235 335 IGISLGSAIGGVVLEHTHSVISTAHVGAGVVVIALICGI 373
Cdd:cd17320 341 LIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
8-370 |
3.16e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 82.47 E-value: 3.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 8 LAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYF 87
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 88 SPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDH--FGWRTVFLGIAF 165
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 166 LSIISIILIYVFLENIPTEEVQPISVQIKS---------LGSVKMASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYW 236
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKsvlkllkrvLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 237 ISICYFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAPPQQNYIIQ 316
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 517537235 317 IDPDASD-IQQSINNSALQIGISLGSAIGGVVLEHTHSVISTAHVGAGVVVIALI 370
Cdd:cd06174 321 LFPPEIRgTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
5-350 |
1.41e-15 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 77.65 E-value: 1.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 5 VFILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVM 84
Cdd:PRK10213 22 VFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 85 TYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIA 164
Cdd:PRK10213 102 VSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 165 FLSIISIILIYVFLENIPTEEVQPISVQIKSLGSVKMASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLF 244
Cdd:PRK10213 182 VMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 245 GLSAVFGGAFGGTLADRigSQKSIL----LVISSFAIVLFLLPYSTFsfpIFLVAMLLWGaLSWSLAP-PQQNYIIQIDP 319
Cdd:PRK10213 262 GIASFVGTSLSSFILKR--SVKLALagapLVLAVSALVLTLWGSDKI---VATGVAIIWG-LTFALVPvGWSTWITRSLA 335
|
330 340 350
....*....|....*....|....*....|.
gi 517537235 320 DASDIQQSINNSALQIGISLGSAIGGVVLEH 350
Cdd:PRK10213 336 DQAEKAGSIQVAVIQLANTCGAAIGGYALDN 366
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-282 |
2.62e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 75.62 E-value: 2.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 5 VFILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVM 84
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 85 TYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIA 164
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 165 FLSIISIILIYVFLENIPTEEVQPISVQIKSLGSVKMASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLF 244
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270
....*....|....*....|....*....|....*...
gi 517537235 245 GLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLL 282
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
8-374 |
1.29e-14 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 74.14 E-value: 1.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 8 LAASTIAVGLVELIVGGILPVIADDLNvSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYF 87
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 88 SPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFI--YMGISSslVLGVPIGILITDHFGWRtvflgiaf 165
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIgaVFGIAS--VAGPLIGGAFTDHLSWR-------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 166 lsiisiiliYVFLENIPteevqpisVQIKSLGSVKMASAHLATMFMLAGHYTFYAYFTP-FLETTLNMGQYWISICYFLF 244
Cdd:cd17502 150 ---------WCFYINLP--------IGGLALALLRTILLSSIFGFLFGGALFGLIYYLPlYFQLVLGDSATKSGVRLLPL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 245 GLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAPPQQNYIIQIDPDASDI 324
Cdd:cd17502 213 IIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPA 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 517537235 325 QQSINNSALQIGISLGSAIGGvvlehthSVISTAHVGAGVVVIALICGII 374
Cdd:cd17502 293 DVGVATATNTFFRSLGGTLGV-------AITDVFLVALALAALAFLLSLF 335
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-370 |
1.09e-13 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 71.92 E-value: 1.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 13 IAVGLVELIVGGI-------LPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMT 85
Cdd:cd17355 6 AVTFLILILSWGIryyfgvfIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 86 YFSPNF--FIVMVARVITAMSTALVVVLSLTIAAKiVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGI 163
Cdd:cd17355 86 ALATSLwqLYLLWGLLGGGGAGTLAAVAFATVAAW-WFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 164 AFLSIISIILIYVFLENIPTEEVQPISVQIK---SLGSVKMASAH-----LATMFMLAG--HYTFYAYFTPFLeTTLNMG 233
Cdd:cd17355 165 ALLALLVLVPVLLLLRRRPADLALRAYDDASpasPGSTLKEALRSasfwlLALAFFLCGfaVVGLIVHLVPYL-ADRGIS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 234 QYWISICYFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAPPQQNY 313
Cdd:cd17355 244 PAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAAL 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 517537235 314 IIQI-DPDASDIQQSINNSALQIGISLGSAIGGVVLEHTHSVISTAHVGAGVVVIALI 370
Cdd:cd17355 324 AARYfGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
4-301 |
2.49e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 70.68 E-value: 2.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 4 KVFILAASTIAVgLVELIVGGILPVIADD-LNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGN 82
Cdd:cd17473 1 LITLLLASTLTV-MAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 83 VMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDhFGWRTVFL- 161
Cdd:cd17473 80 VAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLv 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 162 -GIAFLSIISIILIYVFLENIPTEEVQPISVQIKSLGSVKMASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISIC 240
Cdd:cd17473 159 yLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLA 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517537235 241 YFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTfSFPIFLVAMLLWGA 301
Cdd:cd17473 239 LAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALAS-GLWVVLLGAILAGL 298
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
21-300 |
1.26e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 68.80 E-value: 1.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 21 IVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVI 100
Cdd:cd17328 17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 101 TAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHF-GWRTVFLGIAFLSIISIILIYVFLE 179
Cdd:cd17328 97 VGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 180 ----NIPTEEVQPISVQIKSLGSVKMASAHLATMFMLAGH--YTF----YAYFTPFLETTLNMGQYW----ISICYFL-F 244
Cdd:cd17328 177 epprGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFtaVSFvtgaLAFWAPTFFLRAFGVGDLssadVGLIFGAiT 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517537235 245 GLSAVFGGAFGGTLADRIGSQKS----ILLVISSF--AIVLFLLPYSTFSFPIFLVAMLLWG 300
Cdd:cd17328 257 CIAGVLGVLLGGILADRLRRKTPradpLVCAVGLLaaAPFLFLALVLALSNLLLAWVLLFLG 318
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
20-301 |
2.43e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 67.61 E-value: 2.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 20 LIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARV 99
Cdd:cd17365 16 AVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 100 ITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAflsiisiiliyvfle 179
Cdd:cd17365 96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG--------------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 180 nipteeVQPISVQIKSLGSVKMASAHLATMFMLAGHYTFYAYFtpFLETTLNMGQywISICYFLFGLSAVFGGAFGGTLA 259
Cdd:cd17365 161 ------VPPLILLPLLRGTLLLWVTFFMGLLLVYLLNSWLPKL--MVEAGYSLSQ--ALTITLLLNIGGVIGSLLLGWLA 230
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 517537235 260 DRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGA 301
Cdd:cd17365 231 DRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGA 272
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
22-380 |
7.81e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.05 E-value: 7.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 22 VGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVIT 101
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 102 AMSTALVVVLSLTIAAKIVdPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLENI 181
Cdd:COG2807 117 GAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 182 PTEEVQPiSVQIKSLGSVKMASAHLATMFMLAGHYTFYAYFT--PFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLA 259
Cdd:COG2807 196 PAAAAAA-PAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAwlPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 260 DRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAPpqqnYIIQIDPDASDIQQSINNSALQIGIS- 338
Cdd:COG2807 275 DRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPL----ALTLIGLRARTPAEAAALSGMAQSVGy 350
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 517537235 339 LGSAIG----GVVLEHTHSVISTAHVGAGVVVIALICGIIsLTRPY 380
Cdd:COG2807 351 LLAALGpllvGALHDATGSWTAALLLLAALAVLMLVAGLL-AGRPY 395
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
6-300 |
2.11e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.88 E-value: 2.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 6 FILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMT 85
Cdd:COG0738 11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 86 YFSPNFFIVMVARVITAMSTALVVVLSLTIAAkIVDPAHRAKALGFIYMGISSSLVLGVPIG---ILITDHFGWRTVFLG 162
Cdd:COG0738 91 ALAPSYPLLLLALFLLGLGLGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGgllILLGLSLSWHLPYLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 163 IAFLSIISIILIYVF---LENIPTEEVQPISVQIKSLGSVKMASAHLATMFMLAG-HYTFYAYFTPFLETTLNMGQYWIS 238
Cdd:COG0738 170 LAVLLLLLALLFLRSklpEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGaEGAIGDWLPLYLKDVLGLSEATAA 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517537235 239 ICYFLFGLSAVFGGAFGGTLADRIGSQKsILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWG 300
Cdd:COG0738 250 LGLSLFWGGMTIGRFLGGFLLKRFGPVR-LLRLSALLAAVGLLLALLAPGPWLALIGLALVG 310
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
5-262 |
2.54e-11 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 64.52 E-value: 2.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 5 VFILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVM 84
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 85 TYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIA 164
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 165 FLSIISIILIYVFLENIpteevqpisvqikslgsvkmasahLATMFMLAGHY-TFYAYFTPF---LETTLNMGQYWISIC 240
Cdd:cd17323 161 IISGFCLILIFLFLPIV------------------------LLLGLYVGLVYaILYLFLTAFpyvFGEVYGFSPGEVGLM 216
|
250 260
....*....|....*....|..
gi 517537235 241 YFLFGLSAVFGGAFGGTLADRI 262
Cdd:cd17323 217 YLPIGIGALIGSIIGGRLSDYY 238
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
5-373 |
3.48e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 63.77 E-value: 3.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 5 VFILAASTIAVGLVELIVGGILPVIA--DDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGN 82
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAaeFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 83 VMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHF----GWRT 158
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 159 VFLGIAFLSIISIILIYVFLENIpteevqpisvqikslgsvkmasahLATMFMLAGHYTFYAYFTPFLETTLNMGQYWIS 238
Cdd:cd17316 161 LFLIGALPALLALLLRRRTLLLI------------------------LLWFFISFGYYGLTTFLPTYLQTVLGLSPATSS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 239 ICYFLFGLSAVFGGAFGGTLADRIGSQKsiLLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAPPQQNYIIQI- 317
Cdd:cd17316 217 LYLLLISLGALVGALIAGLLSDRIGRKK--TLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLa 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 517537235 318 ---DPDASDIQQSINNSALQIGISLGSAIGGVVLEHTHSVISTAHVGAGVVVIALICGI 373
Cdd:cd17316 295 elfPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
5-374 |
3.91e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.15 E-value: 3.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 5 VFILAASTIAVGLVELIVGGILPVI-ADDLNVSLGTAGQLITVFALIYAISGPVL--LS--LTAKIERKKLYLLALFIFF 79
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYFyTDVLGLSAALVGLILLVARLWDAITDPLIgaLSdrTRTRWGRRRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 80 -LGNVMTYFSPNF--------FIVMVARVITAMSTALVVVLSLtIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILI 150
Cdd:COG2211 92 aLSFVLLFTAPDLsptgkliyALVTYLLLGLAYTLVNIPYSAL-GAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 151 TDHF------GWRTVFLGIAFLSIISIILIYVFLE--NIPTEEVQPISVQIKSLGSVKMASAHL-ATMFMLAGHYTFYAY 221
Cdd:COG2211 171 VAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKerPVPEEEKVSLKESLKALLKNRPFLLLLlAYLLFFLALALVAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 222 FTPFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLP-YSTFSFPIFLVAMLLWG 300
Cdd:COG2211 251 LLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFfLGPGNLWLLLVLAALAG 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 301 ---ALSWSLAPPQQNYIIQIDPDASDIQQ-----SINNSALQIGISLGSAIGGVVLEHTHSVISTAHVGAGVVVIALICG 372
Cdd:COG2211 331 iglGAILVLPWAMLADVVDYDEWKTGRRReglyfGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFF 410
|
..
gi 517537235 373 II 374
Cdd:COG2211 411 LL 412
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
5-164 |
7.97e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.98 E-value: 7.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 5 VFILAASTIAVGLVELIVGGILPVIADDL-NVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNV 83
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 84 MTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGI 163
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
.
gi 517537235 164 A 164
Cdd:cd17325 361 A 361
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
40-370 |
2.27e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 61.44 E-value: 2.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 40 AGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMSTALVVVlSLTIAAKI 119
Cdd:cd17330 36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 120 VDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLENIPteevqpisvqikslgsv 199
Cdd:cd17330 115 TDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLR----------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 200 kmaSAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFGLS-AVFGGAFGGTLADRIGSQKSILLVISSFAIV 278
Cdd:cd17330 178 ---RLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAgILAQLLLIPRLAKRLGERKLLRLGLLLAIIG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 279 LFLLPYSTFSFPIFLVAMLLwgALSWSLAPPQqnYIIQIDPDASDIQQSINNSALQIGISLGSAIGGVVLEHTHSVIS-- 356
Cdd:cd17330 255 LLLLPFASSVPLLVLAAAIL--AFGTGIVFPA--LSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGpg 330
|
330
....*....|....*
gi 517537235 357 -TAHVGAGVVVIALI 370
Cdd:cd17330 331 vPFLLAAGLLLIALF 345
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
8-306 |
2.69e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 61.42 E-value: 2.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 8 LAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYF 87
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 88 SPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGvPIGILITDHFGWRTVFLGIAFLS 167
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGALPFLIAAVLLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 168 IISIILIYVFLENIPTEEVQPISV-QIKSLGSVKMASAhLATMFMLAGHYTFYAYFTpfleTTLNMGQYWISICYFLFGL 246
Cdd:cd17477 160 LALVPLLLTRRAAPEIEEAESISLrRLLRIAPLALLGA-FVAGFLEGAFYSLLPLYG----LRLGLSVAQAALLLAAFVL 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 247 SAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSL 306
Cdd:cd17477 235 GGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPL 294
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
60-379 |
1.65e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 58.77 E-value: 1.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 60 SLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMSTALVVVLSLtiAAKIVDPAHRAKALGFIYMGISSS 139
Cdd:cd17472 54 LLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVVMAL--LADLTREENRTKAMALIGASIGIA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 140 LVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLENiPTEEVQPISVQIKSLGSVKMASAHL---ATMFMLagHY 216
Cdd:cd17472 132 FAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPD-PPKIVQISEKEKKKLKKLLKNKRLLrldFSIFIL--HF 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 217 TFYAYFT--PFLETTLnmgqYWISICYFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTF-----SF 289
Cdd:cd17472 209 VLMAFFYilPLLLTQL----GGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLlfaatSL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 290 PIFLVAMLLWGALSWSLAPPQQNYI-IQIDPDASDIQQSINNSALQIGISLGSAIGGVVLEHthsvISTAHVGAGVVVIA 368
Cdd:cd17472 285 WLLIIGLIIFFIGFNLLEALLPSLVsKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGL----LGYSSVFLTILILA 360
|
330
....*....|.
gi 517537235 369 LICGIISLTRP 379
Cdd:cd17472 361 LLWLLVSFLLP 371
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
25-297 |
4.88e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 57.62 E-value: 4.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 25 ILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLA-LFIFFLGNVMTYFSPNFFIVMVARVITAM 103
Cdd:cd17490 18 FLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIgLLFTVLASLIMILFPSPWGLLIARFLSGI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 104 STALVVVLSLTIAAkIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFL-GIAFLSIISIILIYVFLENIP 182
Cdd:cd17490 98 AAATWVSFTVLYAS-YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLlAALAGVLGFILSLFIKEERRE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 183 TEEVQPISVQIKSLGSVK-MASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLA-D 260
Cdd:cd17490 177 KKPVLTELKELLSVLKDKkLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyK 256
|
250 260 270
....*....|....*....|....*....|....*..
gi 517537235 261 RIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAML 297
Cdd:cd17490 257 KLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQAL 293
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
20-300 |
5.88e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 57.31 E-value: 5.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 20 LIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARV 99
Cdd:cd17371 16 LLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 100 ITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILI----TDHFGWRTVFL-GIAFLSIISIILI 174
Cdd:cd17371 96 LAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLfpllPPEIAWRVLFLlGALPALLVLFIRR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 175 YV-----FLENIPTEEVQPISVQIKSLGSVKMASAHLATMFM----LAGHYTFYAYFTPFLETTLNMGQYWISICYFLFG 245
Cdd:cd17371 176 FVkeppqWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLatgaLGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTI 255
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 517537235 246 LSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWG 300
Cdd:cd17371 256 LGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLG 310
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
20-303 |
5.96e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 57.37 E-value: 5.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 20 LIVGGILPVIADDLNVSLGTAGQLITvFALIYAISGPVLLSLTA-KIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVAR 98
Cdd:TIGR00895 34 AAMGFAAPAISAEWGLDPVQLGFLFS-AGLIGMAFGALFFGPLAdRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILR 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 99 VITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFL 178
Cdd:TIGR00895 113 FLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 179 ---------------------------ENIPTEEVQPISVQIKSLGSVKMASAH----------LATMFMLAGHYtFYAY 221
Cdd:TIGR00895 193 pesidflvskrpetvrrivnaiapqmqAEAQSALPEQKSTQGTKRSVFKALFQGktaritvllwLLYFMLLVGVY-FLTN 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 222 FTPFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSfAIVLFLLPYSTFSFPIFLVAMLLWGA 301
Cdd:TIGR00895 272 WLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLG-AVFAVLVGSTLFSPTLLLLLGAIAGF 350
|
..
gi 517537235 302 LS 303
Cdd:TIGR00895 351 FV 352
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
29-350 |
6.28e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 57.24 E-value: 6.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 29 IADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMSTALV 108
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 109 VVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIG-ILITDHFGWRTVFLGIAFLSIISIILIYvFLENIPTEEVQ 187
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGgLLLLYSFRLLFLAAAVLFLLAALVLLFL-LPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 188 PISVQIKSLGSVKMASAH----LATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLADRIG 263
Cdd:cd17329 185 EKTEILRGYKIVLRDRAFllflLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 264 SQKSILLVISSFAIVLFLLPYSTfSFPIFLVAMLLWGALSWSLAPPQQNYIIQIDPDASDIQ-QSINNSALQIGISLGSA 342
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFAN-TLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSyMGFYALAWGLGRAIGPL 343
|
....*...
gi 517537235 343 IGGVVLEH 350
Cdd:cd17329 344 VGGLLLDL 351
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
6-347 |
8.69e-09 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 56.88 E-value: 8.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 6 FILAASTIAV---GLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGN 82
Cdd:cd17388 3 FILVTVLLDAmgiGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 83 VMTYFSPNFFIVMVARVITAMSTALVVVLSLTIaAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHfGWRTVFLG 162
Cdd:cd17388 83 LLMAFAPTLWWLYLGRIIAGITGATGAVAAAYI-ADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 163 IAFLSIISIILIYVFL-ENIPTE--------EVQPISvQIKSLGSVKMASAHLATMF--MLAGH--YTFYAYFTpflETT 229
Cdd:cd17388 161 AAGLNGLNFLLGLFVLpESLPPErrrafrwrRANPFG-SLRWLTGFPGLLGLLAVFFliQLIGQvpATTWVLFT---EDR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 230 LNMGQYWISICYFLFG-LSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLwgALSWSLAP 308
Cdd:cd17388 237 FDWSPTMVGLSLAVFGlLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILL--ALGGIAGP 314
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 517537235 309 PQQNYI-IQIDPDASDIQQSINNSAlqigISLGSAIGGVV 347
Cdd:cd17388 315 ALQGLLsRQVPENEQGELQGVLTSL----TSLTSIIGPLL 350
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
26-370 |
1.20e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.08 E-value: 1.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 26 LPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKL-----YLLALFIFFLGNVMTYFSPNFFIVMVARVI 100
Cdd:cd06173 22 LPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLAFL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 101 TAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLEN 180
Cdd:cd06173 102 LGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 181 IPTEEVQPISVQIKSL--------GSVKMASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFGLSAVFGG 252
Cdd:cd06173 182 PPAAPGESSSLLLRDLreglrylrRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 253 AFGGTLADRIGSQKSILLVISSFAIVLFLLPYSTfSFPIFLVAMLLWGaLSWSLAPPQQNYIIQIDPDASDIQQ--SINN 330
Cdd:cd06173 262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP-SLWLLLAALFLLG-LAGGLFNVPLNTLLQLRVPDELRGRvfSVYN 339
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 517537235 331 SALQIGISLGSAIGGVVLEHTHSVISTAHVGAGVVVIALI 370
Cdd:cd06173 340 ALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALL 379
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
22-374 |
1.58e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 55.65 E-value: 1.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 22 VGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVIT 101
Cdd:cd17319 22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 102 AMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLENI 181
Cdd:cd17319 102 GVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 182 pteevqpisvqikslgsVKMAsahLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLADR 261
Cdd:cd17319 182 -----------------WGLA---LGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 262 IGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLL---------WGALSWSLAPpqqnyiIQIDPDASDIQQSINNSA 332
Cdd:cd17319 242 LLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLslagfgigaASPVFWSLPA------DLLPGEAAATAGGLINSG 315
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 517537235 333 LQIGISLGSAIGGVVLEHTHSVISTAHVGAGVVVIALICGII 374
Cdd:cd17319 316 GNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
2-161 |
7.11e-08 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 53.76 E-value: 7.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 2 NFKVFILAASTIAVG-LVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFL 80
Cdd:PRK11652 6 NVNLLFMLVLLVAVGqMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFIL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 81 GNVMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVF 160
Cdd:PRK11652 86 GTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACY 165
|
.
gi 517537235 161 L 161
Cdd:PRK11652 166 L 166
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-177 |
8.62e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.77 E-value: 8.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 2 NFKVFILAASTIAVGLVELIVGGILPVIADD-LNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFL 80
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 81 GNVMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVF 160
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*..
gi 517537235 161 LGIAFLSIISIILIYVF 177
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
10-271 |
2.86e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 51.92 E-value: 2.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 10 ASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSP 89
Cdd:cd06180 6 ALAVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 90 NFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVL-GVPIGILITDHFGWRTVFLGIAFLSI 168
Cdd:cd06180 86 GFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALsGLLVPAGLGGGLSWRAGWLALALLSA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 169 ISIILIYVFLENI---PTEEVQPISVQIKSLGSVKMASAHLatmfmLAGH-YTFYAYFTPFLETTLNMGQYWISICYFLF 244
Cdd:cd06180 166 VLLLLSFLLLRRGpsaPTEASAAESAPGLNRPLWRLALAYG-----LFGFgYIITATFLPLIARETGAGSLLAGLLWSLF 240
|
250 260
....*....|....*....|....*..
gi 517537235 245 GLSAVFGGAFGGTLADRIGSQKSILLV 271
Cdd:cd06180 241 GLAAVPSCFLWGALSDRWGTRRALAAN 267
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
25-308 |
6.03e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.02 E-value: 6.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 25 ILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMS 104
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 105 TALVVVLSLTIAAkIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLENIPTE 184
Cdd:cd17478 98 SAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 185 EVQPISVQIKSLGSVKMASAHLATMFMLAGHYTFYAYFT---PFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLADR 261
Cdd:cd17478 177 AKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTtflPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR 256
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 517537235 262 IGSQKSILLVISSFAIVLFLLPYStfSFPIFLVAMLLWGALSWSLAP 308
Cdd:cd17478 257 FGRRRVIIASLLLAAPFLLLFLLT--PGIWSYILLVLAGFLLFASFP 301
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
44-164 |
2.06e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 49.63 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 44 ITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPA 123
Cdd:TIGR00898 133 QSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKK 212
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 517537235 124 HRAKALGFIYMGISSSLVLGVPIGILITDhfgWRTVFLGIA 164
Cdd:TIGR00898 213 QRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWLQLAVS 250
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
25-351 |
2.33e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 49.18 E-value: 2.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 25 ILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMS 104
Cdd:cd17476 20 ILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 105 TALVVVLSLTIAAKIVDPaHRAKALGFIYMGISSSL--VLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLenip 182
Cdd:cd17476 100 PAFLLPNAMALLGRTYPP-GPRKNIVFSLFGATAPLgfALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWT---- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 183 teevqpisvqikslgSVKMASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLADRI 262
Cdd:cd17476 175 ---------------SPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 263 GSQKSILLVISSFAI--VLFLLPYSTFSF-PIFLVAMLL--WG-ALSWSLAppqqnyIIQIDPDASDIQQ----SINNSA 332
Cdd:cd17476 240 PPSYIMAISMVAFLVgpILFATMPVHQTYwAQAFPAMIVapFGmDFSFPAA------TIIASNAVPREYQglagSLVNTV 313
|
330
....*....|....*....
gi 517537235 333 LQIGISLGSAIGGVVLEHT 351
Cdd:cd17476 314 VNYGISIGLGIAGTVETSV 332
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
30-165 |
3.49e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 48.78 E-value: 3.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 30 ADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMSTALVV 109
Cdd:cd17313 273 SSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATIN 352
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 517537235 110 VLSLTIAAKIVDPAHR--AKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAF 165
Cdd:cd17313 353 INPYPLVSDYHSESGRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAV 410
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
25-298 |
4.96e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.99 E-value: 4.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 25 ILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIV-MVARVITAM 103
Cdd:cd17353 25 FNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLfLGYGVLGGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 104 STALVVVLSLTIAAKIVdPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLENIPT 183
Cdd:cd17353 105 GAGIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPK 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 184 EEVQPISVQIKSLGSVKMASAHLATMFMLAGHYTFYAYF----TPFLETTLNMGQYWISICYF-------LFGLSAVFGG 252
Cdd:cd17353 184 GWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFflnaTAGLMLIGQAKPIGQEFAGLdagiaalAVSILSIFNG 263
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 517537235 253 A---FGGTLADRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLL 298
Cdd:cd17353 264 GgrpFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVAL 312
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
3-368 |
1.05e-05 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 47.02 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 3 FKVFILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGN 82
Cdd:cd17314 3 FVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 83 VMTYFSPN-FFIVMVARVITAMSTALVVVLSLTIAAKIVdPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFL 161
Cdd:cd17314 83 TYLSYVFNsFPLSYACFVFIGAGTGILYGSAVLVTTQYF-PDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 162 GIAFLSIISIILIYVFLENIPTEEVQPISVQIKSLGSVKMASAHLATMFMlagHYTFYAYFTPFLETTLNMGQYWISICY 241
Cdd:cd17314 162 ILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWIL---FIAIFLVLIGGFLFIANMASLVRSLQL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 242 F----------LFGLSAVFGGAFGGTLADRIGSQ---KSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAP 308
Cdd:cd17314 239 DapsfvtklmsIYGLFNAFGRLLWGIVADFFGGRlstLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTV 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 309 PQQNYIIQIDPDASDIQQSINNSALQIGISLGSAIGGVVLEHTHSVISTAHVGAGVVVIA 368
Cdd:cd17314 319 YPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLA 378
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
45-165 |
1.09e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 46.80 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 45 TVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAH 124
Cdd:cd17317 32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 517537235 125 RAKALGFIYMGISSSLVLGVPIGILITDhfgWRTVFLGIAF 165
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISL 149
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
4-164 |
2.01e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.05 E-value: 2.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 4 KVFILAASTIAVGLVELIVGGILPVIADDLNVSlgTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNV 83
Cdd:cd17489 195 KVLPPALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 84 MTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGI 163
Cdd:cd17489 273 LLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLA 352
|
.
gi 517537235 164 A 164
Cdd:cd17489 353 A 353
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
17-164 |
3.35e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.26 E-value: 3.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 17 LVELIVGGILPVIA----DDLNVSLGTAGQLITVFALIYAIS-GPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNF 91
Cdd:cd17330 185 LIALAFAGLESVFSlflkDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSV 264
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517537235 92 FIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIA 164
Cdd:cd17330 265 PLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAA 337
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
10-370 |
3.78e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 45.31 E-value: 3.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 10 ASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSP 89
Cdd:cd17475 3 LAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 90 NFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSII 169
Cdd:cd17475 83 SYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 170 SIILIYVFLENIPTEEVQPISVQIK------SLGSVKMASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFL 243
Cdd:cd17475 163 AAVLFWLFYREPPAASAATESASTLlrslkeVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 244 FGLSAVFGGAFGGTLADRIGSQK-------SILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWslAPPQQNYIIQ 316
Cdd:cd17475 243 AQLGGALGRIGLGRVSDRVFGGRrrpvlviTAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGW--NGLYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 517537235 317 I-DPDASDIQQSINNSALQIGISLGSAIGGVVLEHTHSVISTAHVGAGVVVIALI 370
Cdd:cd17475 321 SaGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-164 |
4.04e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.25 E-value: 4.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 3 FKVFILAASTIAVGLVELIVGGILPVI-ADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKI--ERKKLYLLALFIFF 79
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 80 LGNVMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTV 159
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
....*
gi 517537235 160 FLGIA 164
Cdd:COG2271 340 FLLLA 344
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
25-161 |
8.18e-05 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 44.33 E-value: 8.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 25 ILPVIADDLNVSLGTAGQ----LITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVI 100
Cdd:PRK14995 24 VLHVAAPTLSMTLGASGNellwIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRAL 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517537235 101 TAMSTALVVVLSLT-IAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFL 161
Cdd:PRK14995 104 LAIGAAMIVPATLAgIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFL 165
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
25-196 |
1.12e-04 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 43.72 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 25 ILPVIADDLNVSlGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMS 104
Cdd:cd17384 19 VVPIIPDYLNEN-VRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 105 TALVVVLSL-TIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLENIPT 183
Cdd:cd17384 98 SACSSVAGMgMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVK 177
|
170
....*....|...
gi 517537235 184 EEVQPISVQIKSL 196
Cdd:cd17384 178 SEESEEGTPWKTL 190
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
25-161 |
1.21e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 43.92 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 25 ILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMS 104
Cdd:PRK03893 42 VLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMG 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 517537235 105 TALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFL 161
Cdd:PRK03893 122 MAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFF 178
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
17-300 |
1.26e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.78 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 17 LVELIVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVM-TYFSPNFFIVM 95
Cdd:cd17341 13 MVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLAlALAVSSYWGLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 96 VARVITAMSTALVVVlSLTIAAKIVDPAHRAKALGFIY----MGISSSLVLGVPI---GILITDHFGWRTVFLGIAFLSI 168
Cdd:cd17341 93 VLGFLLGFAGANFAS-GQPWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPLIagaIVFDGGFVGWRNAFFVPGILLA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 169 ISIILIYVFLENIPT------EEVQPISVQIKSLGSVKMASAHLATMfmlAGHYTFYAYFTPFLETTLNMGQYWISICYF 242
Cdd:cd17341 172 IAAVLVLLFGDDLPTgkasalEFLKVQLAVLKNYRTWILSLLYGVTF---GSFVGFSNVLPTYFKTRFGLPLVTAGILAA 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517537235 243 LFGLSAVFGGAFGGTLADRIGSQKSIL----LVISSFAIVLFLLPYSTFSFPIFLVAMLLWG 300
Cdd:cd17341 249 LFPLAGALARPAGGWLSDRFGGRRRLWwlfiVMTIGAALLSLSLPTSGTNLVLFLALFVALG 310
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
24-303 |
1.30e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 43.75 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 24 GILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAM 103
Cdd:cd17331 21 PVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 104 STALVVvlSLTIAAKIVDPAHRAKALGfiYMGISSSL--VLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLE-- 179
Cdd:cd17331 101 MHAMQA--AQMVVTDLTDPGERAAALG--RLGLSYGIgmVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPsn 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 180 -NIPTEEVQPISVQIKSLGSVKMASAHLAT----------MFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFG-LS 247
Cdd:cd17331 177 tKSKREKEAKESASPPSVFNLKEILRLLRLpgvaflllvkLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGvLG 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 517537235 248 AVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPY--STFSFPIFLVAMLLWGALS 303
Cdd:cd17331 257 MVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFvtTVWQLLVLLLPLVIGGSVL 314
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
40-350 |
1.59e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.41 E-value: 1.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 40 AGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMSTALVVVlSLTIAAKI 119
Cdd:cd17391 38 SGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPN-ATALIASQ 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 120 VDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLENIPTEEVQPISVQIKS-LGS 198
Cdd:cd17391 117 TPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEvWNS 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 199 VK----MASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLF---GLSAVFGGAFGGTLADRIGSQKsiLLV 271
Cdd:cd17391 197 VPnpslLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFsatGVSSLLSAPRLGKLGDRIGHHR--ILL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 272 ISSFAIVLFLLPYSTFSFPIFLVAML-LWGALSWSLAPPQQNYIIQIDPD--ASDIqQSINNSALQIGISLGSAIGGVVL 348
Cdd:cd17391 275 GALLASALLYIPQAFVQTPWQLGILRfLLGLATGGLLPAINSLLAKITPKevAGRI-FGYNQSFQYLGNVAGPLLGSAIA 353
|
..
gi 517537235 349 EH 350
Cdd:cd17391 354 AH 355
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
61-160 |
1.64e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 43.41 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 61 LTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSL 140
Cdd:PRK11551 73 LADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGG 152
|
90 100
....*....|....*....|
gi 517537235 141 VLGVPIGILITDHFGWRTVF 160
Cdd:PRK11551 153 ALASVIGVLAAGDAAWRHIF 172
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
43-296 |
1.75e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 43 LITVFALIYAISGPVLLSLTAK-----IERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVI--TAMSTALVVVLSLT- 114
Cdd:cd17471 33 QIGIFMTLSALSGIVVSQWLGRlsdrgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVllSLGAAAFPQLFALAr 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 115 IAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILIYVFLENIPTE--EVQPISVQ 192
Cdd:cd17471 113 EYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPaqKATPASSL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 193 IKSLGSVKMASAHLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISIcyfLFGLSAVFGGAF---GGTLADRIGSQKsiL 269
Cdd:cd17471 193 VKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGL---LFGLAAALEIPImllAGLLAKRFGKRR--L 267
|
250 260
....*....|....*....|....*..
gi 517537235 270 LVISSFAIVLFLLPYSTFSFPIFLVAM 296
Cdd:cd17471 268 LLAGFLAGVLFYLGLALATSLWQLIAL 294
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
26-160 |
2.29e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 43.00 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 26 LPVIADDLNVSLGTAGQ---LITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITA 102
Cdd:cd06179 17 PAAVLPFIVADLGPSSNstwISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIG 96
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 103 MSTALvVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIG--ILITDHFGWRTVF 160
Cdd:cd06179 97 IGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAgaLVEANAAGWRWIF 155
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
206-311 |
3.82e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.45 E-value: 3.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 206 LATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLpYS 285
Cdd:COG2270 245 LAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAA-YF 323
|
90 100 110
....*....|....*....|....*....|....*..
gi 517537235 286 TFSFPIFLVAMLLWG-------ALSWS----LAPPQQ 311
Cdd:COG2270 324 LTTALAFWILGLLIGlvmggiqALSRSllarLIPPGR 360
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
5-282 |
5.09e-04 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 41.97 E-value: 5.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 5 VFILAASTIAVGLVELIVGGILPVIADDLNVSLGTAGQLI----------TVFALIYAIS-----GP---VLLSLTAKIE 66
Cdd:PRK12382 14 NFSLFRIAFAVFLTYMTVGLPLPVIPLFVHHDLGFGNTMVgiavgiqflaTVLTRGYAGRladqyGAkrsALQGMLACGL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 67 RKKLYLLALFIFFLGNVmtyfspNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPI 146
Cdd:PRK12382 94 AGLAYLLAAILPVSAPF------KFALLVVGRLILGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGALAAGAPL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 147 GILITDHFGwrtvFLGIAFLSIISIILIYVFleNIPTEEVQPISVQIKSLGSVKMASAHLATMFMLAG-HYTFYAYFTPF 225
Cdd:PRK12382 168 GLLLHSHFG----FAALALTTMVLPLLAWAF--NGTVRKVPAHAGERPSLWSVVGLIWKPGLGLALQGvGFAVIGTFVSL 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 517537235 226 LETTLNMGQYWISICyfLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLL 282
Cdd:PRK12382 242 YFASKGWAMAGFTLT--AFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLL 296
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
3-169 |
5.17e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.76 E-value: 5.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 3 FKVFILAASTIAVGLVelivGGILPVI-ADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLG 81
Cdd:cd17370 202 FWLYLLAVALFALGNF----SFAFLILrAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 82 NVMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITDHFGWRTVFL 161
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
|
....*...
gi 517537235 162 GIAFLSII 169
Cdd:cd17370 358 FSAVLALI 365
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
21-165 |
7.78e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 41.40 E-value: 7.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 21 IVGGILPVIADDLNVSLGTAGqLITVFALIYAISGPVLL-SLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARV 99
Cdd:cd17359 19 VINGALPFLQTDFNLTPFLEG-LVVSSALLGAAIGALFAgRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARI 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517537235 100 ITAMSTALVVVLSLTIAAKIVDPAHRAKALGF----IYMGISSSLV----LGVPIGILITDHFGWRTVFLGIAF 165
Cdd:cd17359 98 IGGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlmIVFGQLLAYIvnylIANAGGADWLGAEGWRWMLGLEAI 171
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
205-371 |
8.14e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.06 E-value: 8.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 205 HLATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPY 284
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 285 StFSFPIFLVAMLLWGALSWSLAPPQQNYIIQIDPDASDIQQ-SINNSALQIGISLGSAIGGVVLEHTHSVISTAhvGAG 363
Cdd:cd17329 85 A-HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAfSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLA--AAV 161
|
....*...
gi 517537235 364 VVVIALIC 371
Cdd:cd17329 162 LFLLAALV 169
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
206-386 |
9.30e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.73 E-value: 9.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 206 LATMFMLAGHYTFYAYFTPFLETTLNMGQYWISICYFLFGLSAVFGGAFGGTLADRIGSQKSILLVISSFAIVLFLLPYS 285
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 286 TfSFPIFLVAMLLWGALSWSLAPPQQNYIIQI-DPDASDIQQSINNSALQIGISLGSAIGGVVLEHtHSVISTAHVGAGV 364
Cdd:COG2814 96 P-SLWLLLAARFLQGLGAGALFPAALALIADLvPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRWVFLVNAVL 173
|
170 180
....*....|....*....|..
gi 517537235 365 VVIALICGIISLTRPYGVKQAE 386
Cdd:COG2814 174 ALLALLLLLRLLPESRPAARAR 195
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
26-374 |
2.45e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.49 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 26 LPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIE-RKKLYLLALF---IFFLGnvMTYFSPNFFIVMVARVIT 101
Cdd:cd17335 20 LSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLaavLFFLS--LFFVAQIFWLLLLLVILG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 102 AMSTALVVVLSLTIAAKIVDpAHRAK--------ALGFIYMGISSSLVLG-VPIGILITDHFGWRTVFLGIAFLSIisii 172
Cdd:cd17335 98 AFFSAPVVPLVDSITLQYLG-EERERygkqrlwgSIGFGIAALLVGILIDrSSTYKNYTIAFYVFAVLMLLALLLA---- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 173 liyVFLENIPTEEVQPISVQ--IKSLGSVKMASAHLATMFMLAGHYTFYAYFTPFLETtLNMGQYWISICYFLFGLSAVF 250
Cdd:cd17335 173 ---LKFPFRPKHPEPNENTGglLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQD-LGGSKTLIGLLWTVGVVSEIP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 251 GGAFGGTLADRIGSQKsiLLVISSFAIVLFLLPYSTFSFP-IFLVAMLLWG---ALSWSLAPpqqNYIIQI-DPDASDIQ 325
Cdd:cd17335 249 FFFFSSRLIQRFGHVG--LLYLGLLAYVVRWLLYSFLENPwLVLPIELLHGltfALVWAAAV---SYASAAaPPGLRATA 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 517537235 326 QSINNSALQ-IGISLGSAIGGVVLEHthsvISTAHVGAGVVVIALICGII 374
Cdd:cd17335 324 QGLLQGLYFgLGGGLGSLIGGYLYEA----FGARTTFRFFAIAALAGLLA 369
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
22-380 |
2.45e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 39.52 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 22 VGGILPVI---ADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVAR 98
Cdd:cd17390 12 VSMILPLLsthIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 99 VITAMsTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIG-ILITDHFGWRTVFLGIAFLSIISIILIYVF 177
Cdd:cd17390 92 IPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGgHLAETDGGFYYVALLCSAIFILNAGLVWFL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 178 LenipteevqpisvqiKSLGSVKMASAHLATMFMLaghytFYAYFTPFLETTLNMGQYWISICYFLFGLSAVFGGAFGGT 257
Cdd:cd17390 171 L---------------SKLWDLLLVRFLMGFSVLL-----FRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 258 LADRIGSQKSILLVISSFAIVLFLLPYSTFSFPIFLVAMLLWGALSWSLAPPQQNYII--QIDPDASDIQQSINNSALQI 335
Cdd:cd17390 231 ILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLlsRGKSKERGTLLGVGQSVTSL 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 517537235 336 GISLGSAIGGVVLEhthsvISTAHVGAGVVVIALICGIISLTRPY 380
Cdd:cd17390 311 ARILAPLLSGLLQE-----FSVSGPGLLGAVLALAAILLMLARQR 350
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
21-164 |
2.50e-03 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 39.69 E-value: 2.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 21 IVGGILPVIADDLNVSLGTAGQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVI 100
Cdd:cd17437 15 VMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFV 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517537235 101 TAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGIL---ITDHFGWRtVFLGIA 164
Cdd:cd17437 95 AGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAfsgLPLHVGWR-LMLGVG 160
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
93-295 |
3.18e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 39.20 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 93 IVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKALGFIYMGISSSLVLGVPIGILITD--------HFGWRtvflgIA 164
Cdd:cd17367 103 ILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHtlgedqmaAWGWR-----IP 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 165 FLSIISIILIYVFLENIPTEEV---QPISVQIKSLGSVKMASAH----LATMFMLAGH----YTFYAYFTPFLETTLNMG 233
Cdd:cd17367 178 FLLGGVLAVVVLWLRRGLEETEsfeAIAESNEASAGTLRELRRHprelLLVVGLTAGGtlafYTWTTYLQKFLVNTAGFS 257
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517537235 234 QYWISICYFLFGLSAVFGGAFGGTLADRIGsQKSILLVISSFAIVlfllpystFSFPIFLVA 295
Cdd:cd17367 258 KGDATWITTAALLVFMLLQPLGGRLSDRIG-RRPLLLFFGIGGTL--------ATVPLLSAL 310
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
21-379 |
4.21e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 39.13 E-value: 4.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 21 IVGGILPVIADDLNVSLGTA-----GQLITVFALIYAISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVM 95
Cdd:PRK09874 32 LVMPFLPLYVEQLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 96 VARVITAMSTALVVVLSLTIAAKIvdPAHRAK-ALGFIYMGISSSLVLGVPIGILITDHFGWRTVFLGIAFLSIISIILI 174
Cdd:PRK09874 112 ILRALLGLLGGFVPNANALIATQV--PRNKSGwALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVT 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 175 YVFLEniptEEVQPISVQ--------IKSLGSVKMA-SAHLATMFMLAGHYTFYAYFTPFL-ETTLNMGQ--YWISICYF 242
Cdd:PRK09874 190 LFCIR----ENFQPVSKKemlhmrevVTSLKNPKLVlSLFVTTLIIQVATGSIAPILTLYVrELAGNVSNiaFISGMIAS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 243 LFGLSAVFGGAFGGTLADRIGSQKsiLLVISSFAIVLFLLPYSTFSFPIFL-VAMLLWGALSWSLAPPQQNYIIQidPDA 321
Cdd:PRK09874 266 VPGVAALLSAPRLGKLGDRIGPEK--ILITALIFSVLLLIPMSFVQTPLQLgILRFLLGAADGALLPAVQTLLVY--NSS 341
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517537235 322 SDIQQSI---NNSALQIGISLGSAIGGVVlEHTHSVISTAHVGAGVVVIALICGIISLTRP 379
Cdd:PRK09874 342 NQIAGRIfsyNQSFRDIGNVTGPLMGAAI-SANYGFRAVFLVTAGVVLFNAVYSWNSLRRR 401
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
21-165 |
5.86e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 38.32 E-value: 5.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517537235 21 IVGGILPVIADDLNVSLGTAGQLITVFALIY--AISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVAR 98
Cdd:cd17315 15 VINGALLYIAKDLGFGLSTSLQGLVVSSLLLgaAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGR 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517537235 99 VITAMSTALVVVLSLTIAAKIVdPAHRAKALG-----FIYMGISSSLVLGVPIGILITdhfGWRTVFLGIAF 165
Cdd:cd17315 95 FLLGLGVGLASVLVPLYISEIA-PAKIRGALGtlnqlMITFGILLAYLLGLALSLSPP---GWWRLMFALAA 162
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
53-129 |
6.71e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 38.04 E-value: 6.71e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517537235 53 ISGPVLLSLTAKIERKKLYLLALFIFFLGNVMTYFSPNFFIVMVARVITAMSTALVVVLSLTIAAKIVDPAHRAKAL 129
Cdd:cd17374 50 VGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAI 126
|
|
| |
