|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
22-435 |
2.81e-168 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 479.48 E-value: 2.81e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 22 ILKGSAGNLVEWYDVYIYTAFLAYFQPHFFNSKDPLQGALEGMAVFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMM 101
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 102 SAGSFFIAILPTKDVIGVWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVL 181
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 182 QNVLDKEALAGWGWRIPFAIGGVAALVVLWLRRSMEETVSASQveaaanAKASGEAQPGTLRLLFtKHWKALLICIGVTL 261
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEA------IAESNEASAGTLRELR-RHPRELLLVVGLTA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 262 GGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGITGVLFTWPLMSALAGT 341
Cdd:cd17367 234 GGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHT 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 342 KDPFVAFMLMMGGLLIVGGYTSINALVKAELFPASIRALGVGLGYAIANSLFGGTVPLIGAALQKAGQVELLFTYVTVAI 421
Cdd:cd17367 314 DSPYTAFALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFFWYVAGLI 393
|
410
....*....|....
gi 517593554 422 GISLLVYIFALKNK 435
Cdd:cd17367 394 AISLVVYLRMPETR 407
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
2-427 |
4.39e-131 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 385.70 E-value: 4.39e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 2 STQQAAPQSEAAQTRRAVGNILKGSAGNLVEWYDVYIYTAFLAYFQPHFFNSKDPLQGALEGMAVFAVTFLMRPIGSWFF 81
Cdd:PRK10406 4 STVTADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 82 GRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKRRGFFSS 161
Cdd:PRK10406 84 GRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYAS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 162 FQYVTLIGGQMLALLVLVVLQNVLDKEALAGWGWRIPFAIGGVAALVVLWLRRSMEETvsaSQVEAAANAKAsgeaqpGT 241
Cdd:PRK10406 164 FQYVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET---SQQETRALKEA------GS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 242 LRLLFtKHWKALLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLL 321
Cdd:PRK10406 235 LKGLW-RNRRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSML 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 322 WFGITGVLFTWPLMSALAGTKDPFVAFMLMMGGLLIVGGYTSINALVKAELFPASIRALGVGLGYAIANSLFGGTVPLIG 401
Cdd:PRK10406 314 CFGSLAALFTVPILSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVA 393
|
410 420
....*....|....*....|....*.
gi 517593554 402 AALQKAGQVELLFTYVTVAIGISLLV 427
Cdd:PRK10406 394 LSLKSIGMETAFFWYVTLMAVVAFLV 419
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
28-423 |
1.04e-113 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 340.02 E-value: 1.04e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 28 GNLVEWYDVYIYTAFLAYFQPH-FFNSKDPLQGALEGMAVFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSF 106
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTfFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 107 FIAILPTKDVIGVWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVLQNVLD 186
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 187 KEALAGWGWRIPFAIGGVAALVVLWLRRSMEETVSASQveaaanAKASGEAQPGTLRLLFTKHWKALLICIGVTLGGTVA 266
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEK------AQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 267 FYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGITGVLFTWPLMSALAGTKDPFV 346
Cdd:TIGR00883 235 FYLITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTL 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517593554 347 AFMLMMGGLLIVGGYTSINALVKAELFPASIRALGVGLGYAIANSLFGGTVPLIGAALQKAGQVELLFTYVTVAIGI 423
Cdd:TIGR00883 315 FFFLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALAL 391
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
16-430 |
4.00e-85 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 267.09 E-value: 4.00e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 16 RRAVgniLKGSAGNLVEWYDVYIY-TAFLAYFQPHFFNSKDPLQGALEGMAVFAVTFLMRPIGSWFFGRFADRKGRKAAL 94
Cdd:cd17369 1 RRVA---LASLVGTAIEWYDFFIYgTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 95 TLSVTMMSAGSFFIAILPTKDVIGVWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQMLA 174
Cdd:cd17369 78 VLTLLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 175 LLVLVVLQNVLDKEALAGWGWRIPFAIGGVAALVVLWLRRSMEETvsasqvEAAANAKASGEAQPGTLRLLFTKHWKALL 254
Cdd:cd17369 158 TGVFLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEET------PVFRRAKEAGQVVRAPLVEVLRRHWRALL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 255 ICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGITGVLFTWPL 334
Cdd:cd17369 232 LAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPF 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 335 MSALAGTKDPFVAFMLMMGGLLIVGGYTSINALVKAELFPASIRALGVGLGYAIANSLFGGTVPLIGAALQKA-GQVELL 413
Cdd:cd17369 312 FWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAAtGSWWPV 391
|
410
....*....|....*..
gi 517593554 414 FTYVTVAIGISLLVYIF 430
Cdd:cd17369 392 ALYLAALAVISLVAALF 408
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
22-404 |
5.67e-69 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 225.33 E-value: 5.67e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 22 ILKGSAGNLVEWYDVYIYTAFLAYFQPHFFNSKDPLQGALEGMAVFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMM 101
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 102 SAGSFFIAILPTKDVIGVWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVL 181
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 182 QNVLDKEALAGWGWRIPFAIGGVAALVVLWLRRSMEETVSasqvEAAANAKASGEAQPGTLRllftKHWKALLICIGVTL 261
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEA----FLERKARPTRRELFALLA----NNRRIILLGMLLVA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 262 GGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGITGVLFTWPLMSALAGT 341
Cdd:cd17368 233 GSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAA 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517593554 342 KDPFVAFMLMMGGLLIVGGYTSINALVKAELFPASIRALGVGLGYAIANSLFGGTVPLIGAAL 404
Cdd:cd17368 313 PSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWL 375
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
28-430 |
1.52e-62 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 207.60 E-value: 1.52e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 28 GNLVEWYDVYIYTAFLAYFQPHFFNSKDPLQGALEGMAVFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFF 107
Cdd:cd17366 7 GNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTFC 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 108 IAILPTKDVIGVWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVLQNVLDK 187
Cdd:cd17366 87 IGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLLTE 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 188 EALAGWGWRIPFAIGGVAALVVLWLRRSmeetvsasqveaaanakasgeaqpgtlrllftkhwkaLLICIGVTLGGTVAF 267
Cdd:cd17366 167 AQMLDWGWRIPFLIAAPLGLVGLYLRRP-------------------------------------LLICIGLVLVFNVTN 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 268 YTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPlLLWFGITG-VLFTWPLMSALAGTKDPFV 346
Cdd:cd17366 210 YMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKP-VYAAGLAGlLVLAVPAFLLMNSGSIAAI 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 347 AFMLMMGGLLIVgGYTSINALVKAELFPASIRALGVGLGYAIANSLFGGTVPLIGAALQKAGQVELLFT-YVTVAIGISL 425
Cdd:cd17366 289 FIGLLVLGLLLS-CYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAyYLMVAAVVGL 367
|
....*
gi 517593554 426 LVYIF 430
Cdd:cd17366 368 VAVLF 372
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-427 |
5.53e-59 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 197.44 E-value: 5.53e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 25 GSAGNLVEWYDVYIYTAFLAYFQPHFFNSKDPLQGALegmaVFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAG 104
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGL----LFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 105 SFFIAILPTKDVIGVWalvllvlaRLVQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVLQNV 184
Cdd:cd17316 80 TLLIGLLPTPILLLVL--------RFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 185 LDKEalagWGWRIPFAIGGVAALVVLWLRRSMeetvsasqveaaanakasgeaqpgtlrllftkhwkalLICIGVTLGGT 264
Cdd:cd17316 152 LSGD----WGWRILFLIGALPALLALLLRRRT-------------------------------------LLLILLWFFIS 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 265 VAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGITGVLFTWPLmsALAGTKDP 344
Cdd:cd17316 191 FGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPL--FYLLSGSP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 345 FVAFMLMMGGLLIVGGYTSINALVKAELFPASIRALGVGLGYAIANSLFGGTVPLIGAALQKAGQVELLFTYVTVAIGIS 424
Cdd:cd17316 269 TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVA 348
|
...
gi 517593554 425 LLV 427
Cdd:cd17316 349 LIV 351
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
7-404 |
5.45e-52 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 181.29 E-value: 5.45e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 7 APQSEAAQTRRAVGNILKGSAGNLVEWYDVYIYTAFLAYFQPHFFNSKDPLQGALEGMAVFAVTFLMRPIGSWFFGRFAD 86
Cdd:PRK15075 2 STMTPAASRESKARAILRVTSGNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYID 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 87 RKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVT 166
Cdd:PRK15075 82 RVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSAS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 167 LIGGQMLALLVLVVLQNVLDKEALAGWGWRIPFAIGGVAALVVLWLRRSMEETvsasqvEAAANAKasgeaQPGTLRLLF 246
Cdd:PRK15075 162 QQVAVVFAALLGYLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEET------EEFLARK-----HRPSMREIF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 247 T---KHWKALLICIGVTLGGTVAFYTYTNFILSFMNTTSGI-AKETTSVINFWALFIFMLLqPVYGIISDKVGRKPLLLW 322
Cdd:PRK15075 231 RslaANWRIVLAGMLMVAMTTVSFYLITVYTPTFGKTVLHLsAADSLLVTLCVGVSNFIWL-PIGGALSDRIGRRPVLIA 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 323 FGITGVLFTWPLMSALAGtkDPFVAFMLMMGGLL--IVGGYTSinALVKA--ELFPASIRALGVGLGYAIANSLFGGTVP 398
Cdd:PRK15075 310 FTVLAILTAYPALSWLVA--APSFARMLAVELWLsfLYGSYNG--AMVVAltEVMPAEVRTAGFSLAYSLATAIFGGFTP 385
|
....*.
gi 517593554 399 LIGAAL 404
Cdd:PRK15075 386 AISTWL 391
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
13-433 |
7.78e-51 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 179.52 E-value: 7.78e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 13 AQTRRAvgnILKGSAGNLVEWYDVYIYtAFLAY-FQPHFFNSKDPLQGALEGMAVFAVTFLMRPIGSWFFGRFADRKGRK 91
Cdd:PRK10642 12 GKLRKA---ITAASLGNAMEWFDFGVY-GFVAYaLGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 92 AALTLSVTMMSAGSFFIAILPTKDVIGVWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQ 171
Cdd:PRK10642 88 KILAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 172 MLALLVLVVLQNVLDKEALAGWGWRIPFAIGGVAALVVLWLRRSMEETVSASQ-VEAAANAKASGEAQPG--TLRLLFTK 248
Cdd:PRK10642 168 VLGAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQhVDKLEQGDREGLQDGPkvSFKEIATK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 249 HWKALLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAkETTSVINFWALFIFML-LQPVYGIISDKVGRKPLLLWFGITG 327
Cdd:PRK10642 248 HWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYS-EDHGVLIIIAIMIGMLfVQPVMGLLSDRFGRRPFVILGSVAL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 328 VLFTWPLMSALAGTKDPFVAFMLMMGGlLIVGGYTSINALVKAELFPASIRALGVGLGYAIAnSLFGGTVPLIGAALQKA 407
Cdd:PRK10642 327 FVLAIPAFILINSNVIGLIFAGLLMLA-VILNCFTGVMASTLPAMFPTHIRYSALAAAFNIS-VLVAGLTPTLAAWLVES 404
|
410 420
....*....|....*....|....*.
gi 517593554 408 GQVELLFTYVTVAIGISLLVYIFALK 433
Cdd:PRK10642 405 TQNLMMPAYYLMVVAVIGLITGVTMK 430
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
1-439 |
3.05e-47 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 168.76 E-value: 3.05e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 1 MSTQQAAPQSEAAQTRRAVgniLKGSAGNLVEWYDVYIY--TAFLAyFQPHFFNSKDPLQGALEGMAVFAVTFLMRPIGS 78
Cdd:PRK09952 6 ISTRPDEGTLSLSRARRAA---LGSFAGAVVDWYDFLLYgiTAALV-FNREFFPQVSPAMGTLAAFATFGVGFLFRPLGG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 79 WFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKRRGF 158
Cdd:PRK09952 82 VVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 159 FSSFQYVTLIGGQMLALLVLVVLQNVLDKEALAGWGWRIPFAIGGVAALVVLWLRRSMEETvsasqveaAANAKASGEAQ 238
Cdd:PRK09952 162 YSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEES--------AEFEQQQHEQA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 239 PGTLRL----LFTKHWKALLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKV 314
Cdd:PRK09952 234 AAKKRIpvieALLRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRF 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 315 GRKPLLLWFGITGVLFTWPLMSAL-AGTKDPFVAFMLMMGGL---LIVggytSINALVKAELFPASIRALGVGLGYAIAN 390
Cdd:PRK09952 314 GRRRVYITGALIGTLSAFPFFMALeAQSIFWIVFFSIMLANIahdMVV----CVQQPMFTEMFGASYRYSGAGVGYQVAS 389
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 517593554 391 SLFGGTVPLIGAALQK--AGQVELLFTYVTVAIGISLLVyifALKNKKATH 439
Cdd:PRK09952 390 VVGGGFTPFIAAALVTyfGGSWHSVAIYLLAGCLISAMT---ALLMKDNQR 437
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-437 |
2.58e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 104.19 E-value: 2.58e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 16 RRAVGNILKGSAGNLVEWYDVYIYTAFLAYFQPHFFNSKDPLQGAlegmavFAVTFLMRPIGSWFFGRFADRKGRKAALT 95
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLL------FAIPVLVGALLRIPLGFLVDRFGPRRVLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 96 LSVTMMSAGSFFIAILPTKDVIGVWALVllvlarlvQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQMLAL 175
Cdd:COG2223 75 IGLLLLGIGLLLLALAVSYWLLLLLGLL--------LGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 176 LVLVVlqnvldkeALAGWGWRIPFAIGGVAALVV-LWLRRSMEETVSASQVEAAANAKASGEAqpgtlrllfTKHWKALL 254
Cdd:COG2223 147 FLAPL--------LIAAFGWRNAFLILGILLLVVaVLAWLFLRDPPAGAAAAAKASLRDQLEA---------LRDPRFWL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 255 ICIGVTLGGTvAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGITGVLFTWpL 334
Cdd:COG2223 210 LSLLYFGTFG-SFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLL-L 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 335 MSALAGTKDPFVAFMLMMGGLLIvGGYTSINALVkAELFPASIRALGVGLGYAIANsLFGGTVPLI-GAALQKAGQVELL 413
Cdd:COG2223 288 LALALGSLWLFLVLFLLLGLALG-GGNGAVFALV-PDIFPTKNAGAVYGLVGAAGG-LGGFLGPLLfGALLDATGSYTAA 364
|
410 420
....*....|....*....|....
gi 517593554 414 FTYVTVAIGISLLVYIFALKNKKA 437
Cdd:COG2223 365 FLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
67-388 |
9.96e-22 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 96.60 E-value: 9.96e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 67 FAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVwalvllvlARLVQGFSVGGEYGTSATY 146
Cdd:cd17371 40 GTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI--------LRALAGLGFGGEWAAGAAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 147 MSEAATAKRRGFFSSFQYvtliGGQMLALLVLVVLQNVLDKEALAGWGWRIPFAIGGVAALVVLWLRRSMEETVSASQVE 226
Cdd:cd17371 112 MAEYVPARHRGKALGYVQ----SGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAAR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 227 AAANAKasgeAQPGTLRLLFTKHWKALLICIGVTLGGT-VAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQP 305
Cdd:cd17371 188 AARRHF----ADRPSLRELFSPPLLRTTLLASLLATGAlGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 306 VYGIISDKVGRKPLLLWFGITGVLFTwPLMSALAGTKDPFVAFMLMMGglLIVGGYTSINALVKAELFPASIRALGVGLG 385
Cdd:cd17371 264 AGGFLADRIGRRNNFALFALGSAISI-LLYFFLPLSPTLILILGFPLG--FFASGPFSGMGAYLTELFPTAVRATAQGFC 340
|
...
gi 517593554 386 YAI 388
Cdd:cd17371 341 YNV 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-390 |
6.06e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 93.50 E-value: 6.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 12 AAQTRRAVGNILKGSAGNLVEWYDVYIYTAFLAYFQPHFfnSKDPLQGALegmaVFAVTFLMRPIGSWFFGRFADRKGRK 91
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL--GASPAQAGL----VVTAYLLGAALGAPLAGRLADRFGRR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 92 AALTLSVTMMSAGSFFIAILPTKDVIGVWalvllvlaRLVQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQ 171
Cdd:COG2814 76 RVLLLGLLLFALGSLLCALAPSLWLLLAA--------RFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 172 MLALLVLVVlqnvldkeALAGWGWRIPFAIGGVAALVVLWL-RRSMEETVSASQveaaanakasgEAQPGTLRLLFtkHW 250
Cdd:COG2814 148 ALGPLLGGL--------LADLFGWRWVFLVNAVLALLALLLlLRLLPESRPAAR-----------ARLRGSLRELL--RR 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 251 KALLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWfGITGVLF 330
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI-GLLLLAL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 331 TWPLMSALAGTkdPFVAFMLMMGGLLIVGGYTSINALVkAELFPASIRALGVGLGYAIAN 390
Cdd:COG2814 286 GLLLLALAGSL--WLLLLALFLLGFGFGLLFPLLQALV-AELAPPEARGRASGLYNSAFF 342
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-326 |
1.14e-20 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 91.80 E-value: 1.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 9 QSEAAQTRRAVGNILKGSAGNLVEWYDVYIYTAFLAYFQPHFFNSKDPLQgalegmAVFAVTFLMRPIGSWFFGRFADRK 88
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLG------WIVSAYLLGRAIGLLLFGRLGDRY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 89 GRKAALTLSVTMMSAGSFFIAILPTKDVIGVWalvllvlaRLVQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLI 168
Cdd:COG0477 77 GRKRVLLIGLLLFGLASLLCGLAPSPELLIAA--------RALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 169 GGQMLALLVLVVlqnvldkeALAGWGWRIPFAIGGVAALVVLWLRRSMEETVSASQVEAAANAKASGEAQPGTLRLLFtk 248
Cdd:COG0477 149 LGLALGPLLGGL--------LVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLAL-- 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517593554 249 hWKALLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGIT 326
Cdd:COG0477 219 -LLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
28-400 |
5.64e-18 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 85.79 E-value: 5.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 28 GNLVEWYDVYIYTAFLA--YFQPHFF---NSKDPLQGALEGMAVFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMS 102
Cdd:pfam00083 8 GGFLFGYDTGVIGAFLTliDFFKNFGlskSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 103 AGSFFIAILPTKdvigvWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVLq 182
Cdd:pfam00083 88 IGAVLQGAAKGK-----WSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGL- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 183 nvldKEALAGWGWRIPFAIGGVAALVVL-----------WL--------------RRSMEETVSASQVEAAANAKASGEA 237
Cdd:pfam00083 162 ----NKTSNSDGWRIPLGLQLVPALLLIigllflpesprWLvekgrleearevlaKLRGVPDVDRELDEIKDSLEAGQEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 238 QPGTLRLLFTKHWKALLICIGVTLGGT-------VAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLqpvygii 310
Cdd:pfam00083 238 EKASWKELFSTKTRRQRLLIGVMLQIFqqltginAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFL------- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 311 SDKVGRKPLLLWFGITGVLFTWPLMS-ALAGTKDPFVAFMLMMGGLLIVG-----GYTSINALVKAELFPASIRALGVGL 384
Cdd:pfam00083 311 VDRFGRRPLLLLGAAGMAICFVILGIvALLGVSKSDWAGIVAIVFIALFIaffamGWGPVPWVIVSELFPLSVRSKAMAL 390
|
410
....*....|....*.
gi 517593554 385 GYAiANSLFGGTVPLI 400
Cdd:pfam00083 391 ATA-ANWLANFLIGFL 405
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
66-436 |
1.04e-16 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 81.45 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 66 VFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTkdvigvwaLVLLVLARLVQGFSVGGEYGTSAT 145
Cdd:COG2271 50 LASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS--------FWQLLLLRFLLGLGEAGFFPAALK 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 146 YMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVlqnvldkeALAGWGWRIPFAIGGVAALVVLWLRrsmeetvsasqv 225
Cdd:COG2271 122 LIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW--------LLAAFGWRAAFLILGLPGLLLALLR------------ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 226 eaaanakasgeaqpgtlrllftkhwkaLLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQP 305
Cdd:COG2271 182 ---------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 306 VYGIISDKVGRKPllLWFGITGVLFTWPLMSALAGTKDPFVAFMLMMGGLLIVGGYTSINALVKAELFPASIRALGVGLG 385
Cdd:COG2271 235 LGGWLSDRLGRRR--KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 517593554 386 YAIANsLFGGTVPLIGAALQKAGQVELLFTYVTVAIGISLLVYIFALKNKK 436
Cdd:COG2271 313 NTFGF-LGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
50-433 |
3.25e-14 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 73.76 E-value: 3.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 50 FFNSKDPLQGALEGMAVFAVtFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWALVLlvlar 129
Cdd:cd17359 26 FLQTDFNLTPFLEGLVVSSA-LLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIG----- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 130 lvqGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVLQNVLDKEALAGWGWRIPFAIGGVAALVV 209
Cdd:cd17359 100 ---GLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 210 LWLRRSMEETvsasqveaaanakasgeaqPgtlRLLFTKHWKALLICIGVTL-----GGTVAFYtYTNFIL---SFMNTT 281
Cdd:cd17359 177 LLGMLFIPES-------------------P---RWLVSKGKPILIIGIGLAIfqqfvGINVIFY-YGPEIFqnaGFSENA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 282 SGIAKETTSVINFWALFIFMLLqpvygiiSDKVGRKPLLLW--------FGITGVLFTWPLMSALAGtkdpfvaFMLMMG 353
Cdd:cd17359 234 ALLQTIGIGVVNVIFTIIAILL-------VDKVGRKPLLLIgsigmaisLLLIGTAFYFAPGSQASG-------IVALVL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 354 GLLIVGGY-TSINA---LVKAELFPASIRALGVGLGYA---IANSLFGGTVPLIGAALQKAgqvellFTYVTVAIgISLL 426
Cdd:cd17359 300 ILLFVAFFaMSWGPvtwVLLSEIFPNRIRGLAMGIAVFflwIANFLVSLTFPILLAAFGLA------FTFLIFAV-ICVL 372
|
....*..
gi 517593554 427 VYIFALK 433
Cdd:cd17359 373 AFLFVWK 379
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
66-430 |
1.69e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 68.76 E-value: 1.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 66 VFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVwalvllvlARLVQGFSVGGEYGTSAT 145
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL--------ARFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 146 YMSEAATAKRRG----FFSSFQYVTLIGGqmlallvlvvlqnvldkeALAG------WGWRIPFAIGGVAALVVLWLR-R 214
Cdd:cd17325 108 LIADIAPPEERGramgIFSSAIGLGFLIG------------------PLLGglladaLGYRAPFLVCAALALLALVLAlL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 215 SMEETVSASqveaaanAKASGEAQPGTLRLLFTKHWKALLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVINF 294
Cdd:cd17325 170 LLPEPRPPP-------NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 295 WALFIFMLLQPVYGIISDKVGRKPLLL--WFGITGVLFTWPLMSALagtkdPFVAFMLMMGGLLIVGGYTSINALVkAEL 372
Cdd:cd17325 243 AQGLASALSQPPAGKLSDRIGRKPLILigLLLSAVALLLLPLATSF-----WLLLLLLALLGLGLGLVFPATLALL-ADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 517593554 373 FPASIRALGVGLgYAIANSLFGGTVPLIGAALQKAGQVELLFTYVTVAIGISLLVYIF 430
Cdd:cd17325 317 VPPEGRGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
66-429 |
2.97e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 67.84 E-value: 2.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 66 VFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWalvllvlaRLVQGFSVGGEYGTSAT 145
Cdd:cd06174 36 LFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG--------RFLLGLGSGLIDPAVLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 146 YMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVLQnvldkeALAGWGWRIPFAIGGVAALVV-LWLRRSMEETVSASQ 224
Cdd:cd06174 108 LIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA------SSLGFGWRAVFLIAAALALLAaILLLLVVPDPPESAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 225 VEAAANAKASGEAQPGTLRllftkHWKALLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQ 304
Cdd:cd06174 182 AKNEEASSKSVLKLLKRVL-----KNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 305 PVYGIISDKVGRKPLLLWFGITGVLFTWPLMSALAGTKDPFVAFMLMMgglLIVGGYTSINALVKAELFPASIRALGVGL 384
Cdd:cd06174 257 LLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG---FGLGGLLPLSFALIAELFPPEIRGTAFGL 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 517593554 385 GYAIANSLFGGTVPLIGAALQKAGQVELLFTYVTVAIGISLLVYI 429
Cdd:cd06174 334 LNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
65-432 |
1.00e-11 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 66.15 E-value: 1.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 65 AVFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWALVLLVLARLvqGFSVGGEYGTSA 144
Cdd:cd17364 43 LVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMGWLIFFRFLL--GIGIGGDYPLSA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 145 TYMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVLQNVLDKEALAGW------GWRIPFAIGGVAALVVLWLRRSmee 218
Cdd:cd17364 121 TIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGTyhhadlVWRIVLGLGAIPALSVLYFRKH--- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 219 tvsasqveaaanakasgeaqpgtlrllftkhwkaLLICIGVTLGGTVAFYTYTNF---ILS--FMNTTSGIAKETTSVIN 293
Cdd:cd17364 198 ----------------------------------LLGTAGTWFLLDIAFYGQNLFqstIISaiGFSKTMNAYQELFNIAV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 294 FWALFIFMLLQPVY---GIISDKVGRKPL---------LLWFGITGVLFTWPLMSALAgtkdpFVAFMLMMggLLIVGGY 361
Cdd:cd17364 244 GQLIIALAGTVPGYwftVFLIDRIGRKKIqmmgffgmtIFLLILAGPYDHWKISTIGF-----FVLYGLTF--FFSNFGP 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517593554 362 TSINALVKAELFPASIRALGVGlgyaianslfggtvplIGAALQKAGQV--ELLFTYVTVAIGISLLVYIFAL 432
Cdd:cd17364 317 NTTTFIVPAEVFPARVRSTCHG----------------ISAASGKIGAIvgSFLFLSLTQNIGVRNVLIILAG 373
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
71-404 |
1.73e-11 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 65.87 E-value: 1.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 71 FLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPtkdviGVWALVLLVLARlvqGFSVGGEYGTSATYMSEA 150
Cdd:PRK03893 65 FISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAP-----GYWTLFIARLVI---GMGMAGEYGSSATYVIES 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 151 ATAKRRGFFSSFqyvtLIGGqmlaLLVLVVLQNVLDKEALAGWGWRIPFAIGGVAALVVLWLRRSMEETVSASQVEAAAN 230
Cdd:PRK03893 137 WPKHLRNKASGF----LISG----FSIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKA 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 231 AKA------------------------------SGEAQPGTLRLLFTKHWKALLIC-----------IGVTLGGTVAF-Y 268
Cdd:PRK03893 209 PVRtmvdilyrgehriinilltlaaaaalwfcfAGNLQNAAIVAVLGLLCAAIFISfmvqssgkrwpTGVMLMVVVLFaF 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 269 TYTNFILSFM----NTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGITGVLFTWPLMsALAGTKDP 344
Cdd:PRK03893 289 LYSWPIQALLptylKTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPVF-AIGGANVW 367
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 345 FVAFML----MMG----GLL--IVGGYtsinalvkaelFPASIRALGVGLGYAIAnSLFGGTVPLIGAAL 404
Cdd:PRK03893 368 VLGLLLffqqMLGqgisGLLpkLIGGY-----------FDTEQRAAGLGFTYNVG-ALGGALAPILGALI 425
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
76-404 |
3.94e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 64.69 E-value: 3.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 76 IGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWALVLlvlarlvqGFSVGGEYGTSATYMSEAATAKR 155
Cdd:TIGR00895 67 FGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLA--------GLGLGGLMPNLNALVSEYAPKRF 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 156 RGFFSSFQYVTLIGGQMLALlvlvvlqnvldkeALAGW-----GWRIPFAIGGVAALVVLWLRRS--------------- 215
Cdd:TIGR00895 139 RGTAVGLMFCGYPIGAAVGG-------------FLAGWlipvfGWRSLFYVGGIAPLLLLLLLMRflpesidflvskrpe 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 216 --------MEETVSASQVEAAANAKASGEAQPGTLRLLFTKHW-KALLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAK 286
Cdd:TIGR00895 206 tvrrivnaIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTaRITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLS 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 287 ETTSVInfwALFIF--MLLQPVYGIISDKVGRKPLLLWFGITGVLFtwPLMSALAGTKDPFvAFMLMMGGLLIVGGYTSI 364
Cdd:TIGR00895 286 LAATGG---ALFNFggVIGSIIFGWLADRLGPRVTALLLLLGAVFA--VLVGSTLFSPTLL-LLLGAIAGFFVNGGQSGL 359
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 517593554 365 NALVkAELFPASIRALGVGLGYAIanslfGGTVPLIGAAL 404
Cdd:TIGR00895 360 YALM-ALFYPTAIRATGVGWAIGI-----GRLGAIIGPIL 393
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
75-431 |
4.32e-11 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 64.52 E-value: 4.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 75 PIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAIlpTKDVIgvwalvLLVLARLVQGFSVGGEYGTSATYMSEAATAK 154
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAF--AKDVW------MLYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 155 RRGFFSSFQYVTLIGGQMLALlvlvvlqnvldkeaLAGW--GWRIPFAIGGVAALVVL---------------------- 210
Cdd:cd17358 127 VRGALGSLNQLLVNIGILLGY--------------VLGSflPWRTLALIGAIPPVVFLillffipesprwlakkgreeea 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 211 -----WLRRSMEETVSASQVEAAANAKASGEAQPGTLRLLFTKHW-KALLICIGVT----LGGTVAFYTYTNFIlsFMNT 280
Cdd:cd17358 193 ekslqFLRGKDADISKEAAEIQEELAELEKEAKESSFSDLFQRKYlKPLVIGLGLMlfqqLSGINAVIFYASSI--FDEA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 281 TSGIAKETTSVINFWALFIFMLLQPVygiISDKVGRKPLLLWFGI--------TGVLFTWPLMSALAGTkDPFVAFMLMM 352
Cdd:cd17358 271 GSGLDPNTATIIIGVVQVVGTLVATL---LVDRLGRRPLLLVSAIgmgigllaLGLYFYLQEHGALLSS-VSWLPLVGLV 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 353 GGLLIVG-GYTSINALVKAELFPASIRALGVGLgyAIANSLFGGTVpligaalqkagqVELLFTYVTVAIGISLLVYIFA 431
Cdd:cd17358 347 IYIISFSiGLGPLPWVIMSEIFPAKIKGLAGSL--VTLVNWLFAFI------------VTKTFPFLTLAWGASGTFWIFA 412
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
66-390 |
2.51e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.58 E-value: 2.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 66 VFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTkdvigvwaLVLLVLARLVQGFSVGGEYGTSAT 145
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS--------LWLLLVLRVLQGLGAGALFPAALA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 146 YMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVLqnvldkeaLAGWGWRIPFAIGGVAALVVLWLRRSMEETVSASQV 225
Cdd:pfam07690 109 LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL--------ASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 226 EAAANAKASGEAqpgTLRLLFTKHWKALLICIGVTLGGTVAFYTYtnfiLSFMNTTSGIAKETTSVINFWALFIFMLLQP 305
Cdd:pfam07690 181 KPAEEARLSLIV---AWKALLRDPVLWLLLALLLFGFAFFGLLTY----LPLYQEVLGLSALLAGLLLGLGGLLGAIGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 306 VYGIISDKVGRKPLLLWFGITGVLFTWPLMSALAGTKDPFVAFMLMMGGLLIVGGYTSINALVkAELFPASIRALGVGLG 385
Cdd:pfam07690 254 LLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV-SDLAPKEERGTASGLY 332
|
....*
gi 517593554 386 YAIAN 390
Cdd:pfam07690 333 NTAGS 337
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
35-428 |
7.57e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 57.18 E-value: 7.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 35 DVY--IYTAFLAYFQPHFFNSKdpLQGALEGMAVFAVTFLMRPigswFFGRFADRKGRKAALTLSVTMMSAGSFFIAILP 112
Cdd:cd17478 9 DFYqgFLPALLPLLIAKLGLSY--AQAGLLVSVFSITSSLLQP----LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 113 TKDVIGVwalvllvlARLVQGFSVGGEYGTSATYMSEAATaKRRGFFSSFqYVTliGGQMLALLVLVVLQNVLDKEALAG 192
Cdd:cd17478 83 NYWLLLL--------LVALAGIGSAAFHPEGARLASQAAG-GRRGLAMSI-FSV--GGNLGFALGPLIAAALVALFGGLG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 193 WGWRipFAIGGVAALVVLWLRRSMEETVSASqveaaanakasgEAQPGTLRLLFTKHWKALLICIGVTLGGTVAFYTYTN 272
Cdd:cd17478 151 LLIL--LIIPGLAVALLLLRLRPLKKPEAKK------------AAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTT 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 273 FiLSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGITGVLFTWPLMSAlagtkDPFVAFMLMM 352
Cdd:cd17478 217 F-LPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLT-----PGIWSYILLV 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517593554 353 GGLLIVGGYTSINALVKAELFPASiRALGVGLGYAIANSLFGGTVPLIGAALQKAGQVELLFTYVTVAIGISLLVY 428
Cdd:cd17478 291 LAGFLLFASFPVTVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
61-429 |
7.75e-09 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 57.63 E-value: 7.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 61 LEGMAVFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVwalvllvlARLVQGFSVGGEY 140
Cdd:PRK12307 53 MEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTL--------SRFIVGMGMAGEY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 141 GTSATYMSEA----ATAKRRGFF-SSFQYVTLIGGQMLALLVLVvlqnvldkealagWGWRIPFAIGGVAALVVLWLRRS 215
Cdd:PRK12307 125 ACASTYAVESwpkhLKSKASAFLvSGFGIGNIIAAYFMPSFAEA-------------YGWRAAFFVGLLPVLLVIYIRAR 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 216 MEETVSASQVEAAANAKASGEAQPG---TLRLLFTKHWKALLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVI 292
Cdd:PRK12307 192 APESKEWEEAKLSGKGKHSQSAWSVfslSMKGLFNRAQFPLTLCVFIVLFSIFGANWPIFGLLPTYLAGEGFDTGVVSNL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 293 NFWALFIFMLLQPVYGIISDKVGRKPLLLWFGITGVLFTWPLMSAlagTKDPFVAFMLMMGGLLIVGgyTSINALVKA-- 370
Cdd:PRK12307 272 MTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRI---PQDNYLLLGACLFGLMATN--VGVGGLVPKfl 346
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517593554 371 -ELFPASIRALGVGLGYAIANSlfGGTV-PLIGAALQKAGQVELLFTYVTVAIGISLLVYI 429
Cdd:PRK12307 347 yDYFPLEVRGLGTGLIYNLAAT--SGTFnSMAATWLGITMGLGAALTFIVAFWTATILLII 405
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
76-432 |
1.32e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 56.44 E-value: 1.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 76 IGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWALVLlvlarlvqGFSVGGEYGTSATYMSEAATAKR 155
Cdd:cd17365 49 IGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLT--------GLGLGAAMPNAITLVSEYAPARR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 156 RGFFSSFQYVTL-IGGQMLALLVLVVlqnvldkeaLAGWGWRIPFAIGGVAALVVLWLRRsmeetvsasqveaaanakas 234
Cdd:cd17365 121 RSLAVTLMFCGYpLGAALGGFLAAAL---------IPAFGWRSVFLLGGVPPLILLPLLR-------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 235 geaqpGTLrllftkhwkALLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLqpvyGIISDKV 314
Cdd:cd17365 172 -----GTL---------LLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLL----GWLADRF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 315 GRKPLLLWFGITGVLFtwpLMSALAGTKDPFVAFMLMMG-GLLIVGGYTSINALVkAELFPASIRALGVglGYAIANSLF 393
Cdd:cd17365 234 GPKRVLALFFALGAVS---LALLGVSPASLVLLYVLVFLaGACVNGAQVGLYALA-ARFYPTEVRATGV--GWALGVGRL 307
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 517593554 394 GGTV-PLIGAALQKAGqveLLFTYVTVAIGISLLVYIFAL 432
Cdd:cd17365 308 GAILgPLLGGLLLAAG---LGPESVFLALAIPAALGALAV 344
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
25-430 |
1.57e-08 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 56.43 E-value: 1.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 25 GSAGNLVEWYDVYIYTAFLAYFQPHFFNSKDPLqgaLEGMAVfAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAG 104
Cdd:cd17315 2 AALGGLLFGYDLGVINGALLYIAKDLGFGLSTS---LQGLVV-SSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 105 SFFIAILPTKDVIGVWALVLlvlarlvqGFSVGGEYGTSATYMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVLQNV 184
Cdd:cd17315 78 ALLSALAPNVWVLIVGRFLL--------GLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 185 ldkealAGWGWRIPFAIGGVAALVVLWLRRSMEETvsasqveaaanakasgeaqpgtlrllftkhwKALLicIGVTLGGT 264
Cdd:cd17315 150 ------PPGWWRLMFALAAVPALLQLLLMFFLPES-------------------------------RALL--VGVGLQLL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 265 --------VAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLqpvygiiSDKVGRKPLLLWfGITGVLFTWPLMS 336
Cdd:cd17315 191 qqltginaVMYYAPTIFKSAGGGTASILASIIVGVVNLLATLVAIRL-------VDKVGRRPLLLI-GFAGMAASLLLLA 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 337 ALAGTKDPfvafMLMMGGLLIVG----------GYTSINALVKAELFPASIRALGVGLGYA---IANSLFGGTVPLIgaa 403
Cdd:cd17315 263 IAFLLPAL----AKAAGWLALLGillyiaafamGAGPVPWLLLSEIFPLRIRGKGMAIATLvnwIFNFIVGLTFLIM--- 335
|
410 420
....*....|....*....|....*..
gi 517593554 404 LQKAGQVELLFTYVTVAIGISLLVYIF 430
Cdd:cd17315 336 VSTIGLAGVFIFFAAVCLLALVFVFFF 362
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
65-389 |
9.19e-08 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 54.25 E-value: 9.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 65 AVFAVTFLmrpIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWalvllvlaRLVQGFSVGGEYGTSA 144
Cdd:TIGR00898 134 SCFFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF--------RLLVGMGIGGIWVQAV 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 145 TYMSEAATAKRRGFFSSFQYVTLIGGQMLallvlvvlqnvldkEALAGW---GWR-------IPFAIGGVAALVV----- 209
Cdd:TIGR00898 203 VLNTEFLPKKQRAIVGTLIQVFFSLGLVL--------------LPLVAYfipDWRwlqlavsLPTFLFFLLSWFVpespr 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 210 -LWLRRSMEETVSASQVEAAANAKA---------------SGEAQPGTLRLLFTKHW-KALLICIGVTLGGTVAFYTYTn 272
Cdd:TIGR00898 269 wLISQGRIEEALKILQRIAKINGKKlpaevlslslekdlsSSKKQYSFLDLFRTPNLrKTTLCLMMLWFTTAFSYYGLV- 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 273 filsfMNTTSgiaketTSVINFWALFIFMLLQ-PVYGIIS---DKVGRKP----LLLWFGITGVlftwpLMSALAGTKDP 344
Cdd:TIGR00898 348 -----LDLGN------LGGNIYLDLFISGLVElPAKLITLlliDRLGRRYtmaaSLLLAGVALL-----LLLFVPVDLYF 411
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 517593554 345 FVAFMLMMGGLLIVGGYTSInALVKAELFPASIRALGVGLGYAIA 389
Cdd:TIGR00898 412 LRTALAVLGKFGITSAFQMV-YLYTAELYPTVVRNLGVGVCSTMA 455
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
63-387 |
9.34e-08 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 54.35 E-value: 9.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 63 GMAVFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVwaLVLLVLARLVQGFSVGGEYGT 142
Cdd:TIGR00887 58 SAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSV--MATLCFWRFWLGVGIGGDYPL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 143 SATYMSEAATAKRRGFFSS----FQYVTLIGGQMLALLVLVVLQNVLDKEA-----------LAGWGWRIPFAIGGVAAL 207
Cdd:TIGR00887 136 SAIITSEFATKKWRGAMMAavfaMQGFGILAGAIVALIVLAGFKHSLEAAAdeasctgscvpAVDYMWRILIGFGAVPAL 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 208 VVLWLRRSMEET------VSASQVEAAANAKASG----EAQPGTLRLLFT-------------------KHWKALLICIG 258
Cdd:TIGR00887 216 LALYFRLTIPETprytadVAKDVEQAASDMSAVLqvkiEAEPDEVEKASTavevpkaswsdffthffkwRHGKHLLGTAG 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 259 VTLGGTVAFY-------------------TYTNFILSFMNTTSG--IAKETTSVINFWALFIFMllqpvygiisDKVGRK 317
Cdd:TIGR00887 296 SWFLLDIAFYgvnlnqkvilsaigysppaATNNAYEELYKTAVGnlIIALAGTVPGYWVTVFLV----------DIIGRK 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 318 PL-LLWFGITGVLFTwplmsALAGTKDPfvafmLMMGGLLIVG---------GYTSINALVKAELFPASIRALGVGLGYA 387
Cdd:TIGR00887 366 PIqLMGFFILTVLFF-----VLGFAYNH-----LSTHGFLAIYvlaqffanfGPNATTFIVPGEVFPTRYRSTAHGISAA 435
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
64-438 |
1.87e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.93 E-value: 1.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 64 MAVFAVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWALVLlvlarlvqGFSVGGEYGTS 143
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLL--------GLGLGLLDVAA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 144 ATYMSEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVLQNVldkealAGWGWRIPF-AIGGVAALVVLWLRRSmeetvsa 222
Cdd:COG0738 118 NPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLG------LSLSWHLPYlILAVLLLLLALLFLRS------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 223 SQVEAAANAKASGEAQPGTLRLLFTKHWKALLICIGVTLGGTVAFYTytnFILSFMNTTSGIAKETTSVINFWALFIFML 302
Cdd:COG0738 185 KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGD---WLPLYLKDVLGLSEATAALGLSLFWGGMTI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 303 LQPVYGIISDKVGRKPLLLWFGITGVLFtwpLMSALAGTKDPFVAFMLMMGGLLIVGGYTSINALVKAELFPASIRALGV 382
Cdd:COG0738 262 GRFLGGFLLKRFGPVRLLRLSALLAAVG---LLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 517593554 383 GLGYAIanslFGGTV--PLIGAALQKAGqVELLFTYVTVAIGISLLVYIFALKNKKAT 438
Cdd:COG0738 339 VLIMGI----VGGAIgpPLIGFLADAFG-LRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
193-432 |
2.45e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.98 E-value: 2.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 193 WGWRIPFAIGGVAALV-VLWLRRSMEETVSASqvEAAANAKASgeaqpgtLRLLFTKhwKALLICIGVTLGGTVAFYTYT 271
Cdd:COG2211 180 LGYRLTALIFAVLGLLaFLLTFFGTKERPVPE--EEKVSLKES-------LKALLKN--RPFLLLLLAYLLFFLALALVA 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 272 NFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGITGVLFTwpLMSALAGTKDPFVAFMLM 351
Cdd:COG2211 249 ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL--LLLFFLGPGNLWLLLVLA 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 352 MGGLLIVGGYTSINALVKAELFPA--------------SIRALGVGLGYAIANSLFGGTVPLIGAALQKAGQVELLFTYV 417
Cdd:COG2211 327 ALAGIGLGAILVLPWAMLADVVDYdewktgrrreglyfGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIR 406
|
250
....*....|....*
gi 517593554 418 TVAIGISLLVYIFAL 432
Cdd:COG2211 407 LLFFLLPAVLLLLAA 421
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
76-430 |
4.99e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 51.88 E-value: 4.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 76 IGSWFFGRFADRKGRKAALTLSVTMMSAGS-FFIAILPTKDVIGVwalvllVLARLVQGFSVGGEYGTSATYMSEAATAK 154
Cdd:cd17357 64 IGSFISAFLANRFGRKNGLLISNALLVVSSlLMFLSKSAKSPELL------IFGRFLVGIACGLSTGFVPMYLQEISPSE 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 155 RRGFFSSFQYVTLIGGQMLALLVLVVLQNVLDKealagwGWRIPFAIGGVAALVVL-----------WLRRSM------- 216
Cdd:cd17357 138 LRGALGSLTQIGVTLGILLGQVFGLPSVLGTET------LWPYLLFFPGIPALLQLaalpffpespkFLLISKgdeeeae 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 217 ---------EETVSASQVEAAANAKASGEAQPGTLRLLFTK---HWKALLICI---GVTLGGTVAFYTYTNFILsfmnTT 281
Cdd:cd17357 212 kslkflrgiEDDVDQELEEIKKESEQMGDQKQVSLMQLLRDpslRLPLLLVLVvsaSQQFSGINAIFFYSTFIF----EN 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 282 SGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLwFGITGVLFTWPLMSALAGTKD--PFVAFMLMMGGLLIVG 359
Cdd:cd17357 288 AGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLL-ISLSVCAVALLLMSVFLFLSEqnSWMSYGCIVAIFLFIF 366
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517593554 360 GYT----SINALVKAELFPASIRALGVGLGYAIaNSLFGGTVPLIGAALQK--AGQVELLFtyvtVAIGISLLVYIF 430
Cdd:cd17357 367 FFAiglgPIPWFIGAELFPQAPRSAAQSLGSSV-NWTSNFIVGMAFPPLQSigGGFVFIIF----AIPCALFLLYLY 438
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
68-384 |
2.49e-05 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 46.11 E-value: 2.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 68 AVTFLMRPIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWALVLlvlarlvqGFSVGGEYGTSATYM 147
Cdd:cd17360 42 SSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLV--------GLGVGIASMTVPLYI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 148 SEAATAKRRGFFSSFQYVTLIGGQMLALLVLVVLQNVLDkealagwGWRIPFAIGGVAALVVLWLRRSMEETVSasqvea 227
Cdd:cd17360 114 AEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPG-------GWRWMLGLAAVPAVLQFIGLLFLPESPR------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 228 aanakasgeaQPGTLRllftkhwkALLICIGV----TLGGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFMLL 303
Cdd:cd17360 181 ----------WPSTRR--------ALIVGCGLqafqQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 304 qPVYGIisDKVGRKPLLLW--FGITGVLFTWPLMSALAGTKDPFVAFMLMMGgllivggytSINALVKAELFPASIRALG 381
Cdd:cd17360 243 -GMYLI--DKFGRRKLLLIslFGVIVALVVLAVWLALVGLILYLAFFAPGMG---------PVPWTVNSEIYPLWARGTG 310
|
...
gi 517593554 382 VGL 384
Cdd:cd17360 311 GGC 313
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
64-362 |
4.01e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.63 E-value: 4.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 64 MAVFAVTFLmrpIGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTkdvIGVWALVLLVLarlvqGFSVGGEYGTS 143
Cdd:cd17477 37 ASAYYLGIL---LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS---PWVWFLLRFVM-----GIGLAGLFVVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 144 ATYMSEAATAKRRG----FFSSFQYVTLIGGQMLALLVLVvlqnvldkealAGWgwrIPFAIGGV---AALVVLWLRRSm 216
Cdd:cd17477 106 ESWLNALATNENRGrvlgLYSTVLGLGFALGPLLLALVGT-----------AGA---LPFLIAAVlllLALVPLLLTRR- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 217 eetvsasqveaaaNAKASGEAQPGTLRLLFTKHWKALLICI--GVTLGGTVAFytytnfiLSFMNTTSGIAKETTSVinF 294
Cdd:cd17477 171 -------------AAPEIEEAESISLRRLLRIAPLALLGAFvaGFLEGAFYSL-------LPLYGLRLGLSVAQAAL--L 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 295 WALFIF--MLLQPVYGIISDKVGRKPLLLWFGITGVLFTWPLMSALAGTkdPFVAFMLMMGGLLIVGGYT 362
Cdd:cd17477 229 LAAFVLggLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLP--LALLVLLFLWGGAAGPLYT 296
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
254-432 |
6.72e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 6.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 254 LICIGVTLGGTVAFYTYTNF--ILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFgitgvLFT 331
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLsvAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG-----LLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 332 WPLMSALAGTKDPFVAFMLMMGGLLI-VGGYTSINALVKAELFPASIRALGVGLgYAIANSLFGGTVPLIGAALQKAGQV 410
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWFPPKERGRALGI-FNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180
....*....|....*....|..
gi 517593554 411 ELLFTYVTVAIGISLLVYIFAL 432
Cdd:COG2271 164 RAAFLILGLPGLLLALLRFWLL 185
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
248-401 |
7.59e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.04 E-value: 7.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 248 KHWKALLICIGVTL--GGTVAFYTytnFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGI 325
Cdd:TIGR00895 14 YQWRAIILSFLIMLmdGYDLAAMG---FAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 326 TGVLFTwpLMSALAGTKDPFVAFMLmMGGLLIVGGYTSINALVkAELFPASIRALGVGL-------GYAIANSLFGGTVP 398
Cdd:TIGR00895 91 LFSVFT--LLCALATNVTQLLILRF-LAGLGLGGLMPNLNALV-SEYAPKRFRGTAVGLmfcgypiGAAVGGFLAGWLIP 166
|
...
gi 517593554 399 LIG 401
Cdd:TIGR00895 167 VFG 169
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
76-353 |
2.72e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.92 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 76 IGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAIlptkdvigVWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKR 155
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL--------APSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 156 RGFFSSFQYVTLIGGQMLALLVLVVLQNVldkealagWGWRIPF-AIGGVAALVVLWLRRSMEETvsasqveaAANAKAS 234
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGRPLGGLLGQL--------LGWRAAFlAIAVLALLAALLLWRLLPSL--------PPKKPGS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 235 GEAQPGTLRLLFTKHWKALLICIGVTLGGTVAFYTYTNFILSFMNTTSGiaketTSVInfWALFIFMLL----QPVYGII 310
Cdd:cd17324 185 LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS-----SAII--GLLLLFGVAgvvgSPLAGRL 257
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 517593554 311 SDKVGRKPLLLWFGITGVLftWPLMSALAGTKDPFVAFMLMMG 353
Cdd:cd17324 258 ADRGGRRALLIALLLLAAA--LLLLTLLGPSPLLLLVGLVLWG 298
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
76-430 |
3.09e-04 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 42.77 E-value: 3.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 76 IGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVwalvllvlARLVQGFSVGGEYGTSATYMSEAATAKR 155
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMV--------GRFVAGIGVGFALMIAPVYTAEVAPASS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 156 RGFFSSFQYVTLIGGQMLALLVLVVLQNVLdkealAGWGWRIPFAIGGVAALVVLWLRRSMEEtvsasqveaaanakaSG 235
Cdd:cd17437 119 RGFLTSFPEIFINIGILLGYVSNYAFSGLP-----LHVGWRLMLGVGAVPSLFLAIGVLAMPE---------------SP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 236 EAQPGTLRLlftkhwkaLLICIGVTL----GG--TVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFIFmllqpVYGI 309
Cdd:cd17437 179 RWTPAVRRM--------LIAALGIHFfqqaSGidAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLFIL-----VATF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 310 ISDKVGRKPLLL--WFGITGVLFTWPLMSALAGTKDPFVAFMLMMGGLLIVG-------GYTSINALVKAELFPASIRAL 380
Cdd:cd17437 246 LLDKVGRRPLLLtsTGGMTLSLTALATSLTFIDRNGGGLTWALVLAITAVCSfvaffsiGAGPITWVYSSEIFPLRLRAQ 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 517593554 381 GVGLGYAIaNSLFGGTVPLIGAALQKAGQVE-LLFTYVTVAIGISLLVYIF 430
Cdd:cd17437 326 GASLGVVV-NRLMSGTVSMTFLSMSKAITTGgTFFLFAGVAAAAWVFFYFF 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
297-438 |
3.22e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.94 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 297 LFIFMLLQPVYGIISDKVGRK----PLLLWFGITGVLftwplmSALAGTKDPFVAFMLMMGglLIVGGYTSINALVKAEL 372
Cdd:cd17474 44 TLPAAVLMPVAGVLADRFGRKkvllPGLLLFGIGGLL------CGLSDSFALLLAGRALQG--IGAAGLGPLALTLIGDL 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517593554 373 FPASIRALGVGLgYAIANSLFGGTVPLIGAALQKAGQvELLFTYVTVAIGISLLVYIFALKNKKAT 438
Cdd:cd17474 116 FEGGERAKAMGL-YEAALGLGIAVGPLLGGLLAAISW-RYPFFLLAALIPVAFLAILFLLPEPKEK 179
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
77-409 |
5.27e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 42.26 E-value: 5.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 77 GSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAIlptkdvigVWALVLLVLARLVQGFSVGGEYGTSATYMSEAATAKRR 156
Cdd:PRK11551 66 GALLGGRLADRIGRKRILIVSVALFGLFSLATAQ--------AWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 157 GFFSSFQYVTL-IGGQMLALLVLVVLqnvldkealAGWGWRIPFAIGGVAALVV-----LWLRRSmeetvsasqvEAAAN 230
Cdd:PRK11551 138 GTAVSLMYCGVpFGGALASVIGVLAA---------GDAAWRHIFYVGGVGPLLLvpllmRWLPES----------RAFAQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 231 AKASGEAQPGTLRLLFTKHWKALLICIGVTLGGT-VAFYTYTNFILSFMnTTSGIAKETTSVINFW--------ALFIFM 301
Cdd:PRK11551 199 AAGAGKQRAPVLRALFGEGRATATLLLWISYFFTlIVLYFLLNWLPSLL-VGQGLSRSQAGLVQIAfniggalgSLLIGA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 302 LLqpvygiisDKVGRKP--LLLWFGITGVLftwplmSALAGTkdPFVAFMLMMG---GLLIVGGYTSINALVkAELFPAS 376
Cdd:PRK11551 278 LM--------DRLRPRRvvLLIYAGILASL------AALAAA--PSFAGMLLAGfaaGLFVVGGQSVLYALA-PLFYPTQ 340
|
330 340 350
....*....|....*....|....*....|....*
gi 517593554 377 IRALGVGLGYAIA--NSLFGgtvPLIGAALQKAGQ 409
Cdd:PRK11551 341 VRGTGVGAAVAVGrlGSMAG---PLLAGQLLALGR 372
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
192-353 |
5.42e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 41.90 E-value: 5.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 192 GWGWRIPFAIGGVAALVVLWLRRSMEETVSASQVEAAANAKAsgeaqpgTLRLLFTKHWKALLICIGVTLGGtvaFYTYT 271
Cdd:TIGR00886 164 AWGWAFVIVPAGILLLPALLIFFVGADTPPGKPATGKLSFKE-------ALKVFGNRHTWILALLYSVTFGS---FLGVS 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 272 NFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWF------GITGVLFTWPLMSALAGTKDPF 345
Cdd:TIGR00886 234 SIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNflgvamGAFLVVLGLVSDGSLAAFIVLF 313
|
....*...
gi 517593554 346 VAFMLMMG 353
Cdd:TIGR00886 314 VALFFFAG 321
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
259-449 |
7.52e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.64 E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 259 VTLGGTVAFYTYT--NFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVGRKPLLLWFGITGVLFTWPLMS 336
Cdd:cd06174 1 LLLGFFLTGLARGliSPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 337 AlagTKDPFVAFMLMMGGLLIVGGYTSINALVkAELFPASIRALGVGLgYAIANSLFGGTVPLIGAALQKAGQVELLFTY 416
Cdd:cd06174 81 A---PSFWLLLLGRFLLGLGSGLIDPAVLALI-ADLFPERERGRALGL-LQAFGSVGGILGPLLGGILASSLGFGWRAVF 155
|
170 180 190
....*....|....*....|....*....|...
gi 517593554 417 VTVAIgISLLVYIFALKNKKATHLDDEQGHAWE 449
Cdd:cd06174 156 LIAAA-LALLAAILLLLVVPDPPESARAKNEEA 187
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
76-430 |
1.13e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.18 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 76 IGSWFFGRFADRKGRKAALTLSVTMMSAGSFFIAILPTKDVIGVWALVLlvlarlvqGFSVGGEYGTSATYMSEAATAKR 155
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIY--------GVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 156 RGFFSSFQYVTLIGGQMLALLVLVVlqnvldkEALAGWGWRIPFAIGGVAALV----VLWLrrsmeetvsasqveaaana 231
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGYVSGYA-------FADVVGGWRYMYGLAAPPALLlgigMWFL------------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 232 KASGEAQPGTLRLLFTkhwkALLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVInFWALFIFMLLQPVYGIis 311
Cdd:cd17362 180 PPSPRWQGNYRKPLII----GLGLVLFQQITGQPSVLYYAATIFKSAGFSAASDATLVSVG-LGVFKLLMTIVAVLLV-- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 312 DKVGRKPLLLwFGITGVLFTWPLMSALAGTKDP---FVAFMLMMGGLLIVGGYT----SINALVKAELFPASIRALGVGL 384
Cdd:cd17362 253 DKLGRRPLLL-GGVSGMVVSLFLLAAYNLFVQMgpaGLAWLSLVALLLYVGAYQisfgPISWLMVSEIFPLRVRGRAIAL 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 517593554 385 GYAIaNSLFGGTVPLIGAALQKAGQVELLFTYVTVaIGISLLVYIF 430
Cdd:cd17362 332 AVLV-NFGSNALVSLAFLPLQELIGLPGTFLGFGV-IGVLALLFIY 375
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
132-384 |
1.49e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 40.70 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 132 QGFSVGGEYGTSATYMSEAATAKRRG-FFSSFQYVTLIGgqmlallVLVVLQNVLDKEALAGWGWRIPFAIGGVAALVVL 210
Cdd:cd17361 114 LGFGVGFGNQAVPLYLSEMAPAKLRGaLNIGFQLAITIG-------ILIANLINYGTSKIKPNGWRLSLGLAAVPALILL 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 211 WLRRSMEETVSASQVEAaanakasgeaqpgtlrllftkhwkALLICIGVTLGG--TVAFYTYTNF-ILSFMNTTSGIAKE 287
Cdd:cd17361 187 LGSLFLPETPNSPQLVI------------------------AILIPFFQQLTGinVIMFYAPVLFqTLGFGSDASLISAV 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 288 TTSVINFWALFIFMLLqpvygiiSDKVGRKPLLLWFGITG----VLFTWPLMSALAGTKDPFVAFMLMMGGL--LIVGGY 361
Cdd:cd17361 243 ITGAVNVVSTLVSIYL-------VDRFGRRFLLLEGGVQMlasqVAIGILLAVKFGDGGELPKAYAIAVVVLicLYVAAF 315
|
250 260
....*....|....*....|....*..
gi 517593554 362 ----TSINALVKAELFPASIRALGVGL 384
Cdd:cd17361 316 awswGPLGWLVPSEIFPLETRSAGQSL 342
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
194-427 |
2.61e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.91 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 194 GWRIPFAIGGV-----AALVVLWLRrsmeETVSASQVEAAANAKASGEAQPGTLRLLFtkhwkaLLICIGVTLGGtvAFY 268
Cdd:cd17475 148 GWRAAFVVAGLvsilaAVLFWLFYR----EPPAASAATESASTLLRSLKEVLRNRDVW------LIAIAGALLVA--PQF 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 269 TYTNFILSFMNTTSGIAKETTSVINFWALFIFMLLQPVYGIISDKVG---RKPLLLWFGITGVLFTWPLMSALAGTKDPF 345
Cdd:cd17475 216 ALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLVLSLLSPGTPLWL 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 346 VAFMLMMGGLLIVGGYtSINALVKAELFPASIRALGVGLGYAIANSLFGGTVPLIGAALQKAGQVELLFTYVTVAIGISL 425
Cdd:cd17475 296 LVLLLILLGLFAIGWN-GLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAA 374
|
..
gi 517593554 426 LV 427
Cdd:cd17475 375 LL 376
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
200-429 |
5.21e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 5.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 200 AIGGVAALVVLWLRRSmeetvsasqvEAAANAKASGEAQPGTLRLLFTKHWKALLICIGVTLGgtvaFYTYTNFILSFMN 279
Cdd:cd17370 163 AIPALLALLILLFVVK----------EYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALG----NFSFAFLILRAQE 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 280 TTSGIAkettSVINFWALF--IFMLLQPVYGIISDKVGRKPLLlwfgITGVLFTWPLMSALAGTKDPFVAFMLMMGGLLI 357
Cdd:cd17370 229 LGLSAA----LIPLLYALFnlVYALAAYPAGRLSDRIGRKKLL----ILGYLSLALAYLGFALGSSLWLLLLGFILWGLY 300
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517593554 358 VGGYTSINALVKAELFPASIRA-------LGVGLGYAIANSLFGGTVPLIGAAlqkagqveLLFTYVTVAIGISLLVYI 429
Cdd:cd17370 301 MGAQESIERAAVADLVPAELRGtayglfnTVVGIGWLLASLIAGYLWDLISPS--------AAFLFSAVLALIALLLLL 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
253-432 |
7.27e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 7.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 253 LLICIGVTLGGTVAFYTYTNFILSFMNTTSGIAKETTSVINFWALFiFMLLQPVYGIISDKVGRKPLLLwFGITGVLFTW 332
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLG-QFLASPLWGRLSDRYGRKPVLL-LSLAGSAVSY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517593554 333 PLMsALAGTKDPFVAFMLMMGgllIVGGYTSINALVKAELFPASIRAlgvgLGYAIANSLFG-GTV--PLIGAALQKAGQ 409
Cdd:cd17330 79 VLL-GLSRNLWLLFLARFLDG---LTGGNVSVAQAYIADITDEEERA----KAFGIISAAFGlGFIlgPALGGFLSTPYG 150
|
170 180
....*....|....*....|...
gi 517593554 410 VELLFtYVTVAIGISLLVYIFAL 432
Cdd:cd17330 151 YALPF-LVAAALALLNLVLVLFF 172
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
66-104 |
9.93e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 38.36 E-value: 9.93e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 517593554 66 VFAVTFLMRPIGSWFFGRFADRKGRK-----AALTLSVTMMSAG 104
Cdd:PRK09874 59 VFSITFLFSAIASPFWGGLADRKGRKimllrSALGMGIVMVLMG 102
|
|
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