|
Name |
Accession |
Description |
Interval |
E-value |
| strep_PBP3 |
NF038273 |
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ... |
7-415 |
1.53e-127 |
|
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.
Pssm-ID: 468443 [Multi-domain] Cd Length: 407 Bit Score: 374.98 E-value: 1.53e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 7 KRFIAIVTVLTLFCSMFvtygSASAEtgaALNVEAGAAILVEADSGKILYQKNADELLAIASMTKMMSEYLVNEAVAKGK 86
Cdd:NF038273 1 KKLILLLLLLLAFFLAT----TVSAD---DFDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 87 LKWDQKVKVSEYAHMISQDRSLSNVPLENGgSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMNDKAKELGLKN 166
Cdd:NF038273 74 LSWDTPVKISDYPYELTTNYEISNVPLDAR-KYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 167 YKFVNSTGLTNHDLKGQQPEGTTPDEENKMSARDCAILAQHLIQDFPKVLETAKIPKKVFqeGGKypvKMDNWNWMLKGL 246
Cdd:NF038273 153 AKLVNASGLNNSYLGDHIYPGSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADF--AGT---TIYSYNYMLKGM 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 247 VKEYEGVDGLKTGSTPEAGDCFTGTAERNGMRLISVVIKTN----SHTARFDETKKLFDYGFTNFEVKKVYPKGSAVKGh 322
Cdd:NF038273 228 PYYREGVDGLKTGTTEKAGASFVATSVENGMRVITVVLNADnadeDEYARFTATNQLLDYIYQNFEKVTLVKKGQAYKD- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 323 ETVRVENAKDKDVTIQTKQAIALPMLKGSKDVYKTEFKDVSKDKEAPIKKGTTLGQmiISPKDNND--PGFLsGKSLQVD 400
Cdd:NF038273 307 SKLPVIDGKKKTVSAVAKKDLTVIQKIGTDSKPSVKFTPKKKELTAPIKKGQVVGK--ATFKDKDLigKGYL-GEPPSVE 383
|
410 420
....*....|....*....|..
gi 517613343 401 LITKSEVEKANW-------FVR 415
Cdd:NF038273 384 LVAKKDVKKSFFlkvwwnhFVR 405
|
|
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
7-415 |
3.74e-120 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 352.99 E-value: 3.74e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 7 KRFIAIVTVLTLFcsmfvtygSASAETGAALNVEAGAAILVEADSGKILYQKNADELLAIASMTKMMSEYLVNEAVAKGK 86
Cdd:COG1686 2 KKLLLLALLLLLA--------AAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 87 LKWDQKVKVSEYAHMISqdrsLSNVPLENGGSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMNDKAKELGLKN 166
Cdd:COG1686 74 ISLDDKVTVSEEAARTG----GSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 167 YKFVNSTGLtnhdlkgqqpegttPDEENKMSARDCAILAQHLIQDFPKVLETAKIPKKVFQEGGKYpvKMDNWNWMLkgl 246
Cdd:COG1686 150 THFVNPTGL--------------PDPGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNGRGI--TLRNTNRLL--- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 247 vKEYEGVDGLKTGSTPEAGDCFTGTAERNGMRLISVVIKTNSHTARFDETKKLFDYGFtnfevkkvyPKGSAVKghetVR 326
Cdd:COG1686 211 -GRYPGVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYGF---------PKGEALK----AE 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 327 VEnakdkdvtiqtkqaialpmlkgskdvyktefkdVSKDKEAPIKKGTTLGQMIISpkdnndpgfLSGKSL-QVDLITKS 405
Cdd:COG1686 277 VV---------------------------------LDGPLKAPVKKGQVVGTLVVT---------LDGKTIaEVPLVAAE 314
|
410
....*....|
gi 517613343 406 EVEKANWFVR 415
Cdd:COG1686 315 DVEKAGFFSR 324
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
35-284 |
1.54e-89 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 271.57 E-value: 1.54e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 35 AALNVEAGAAILVEADSGKILYQKNADELLAIASMTKMMSEYLVNEAVAKGKLKWDQKVKVSEYAHMISQDRSlSNVPLE 114
Cdd:pfam00768 2 SAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNPGS-SNIFLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 115 NGGSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMNDKAKELGLKNYKFVNSTGLTNHDlkgqqpegttpdeeN 194
Cdd:pfam00768 81 PGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHG--------------Q 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 195 KMSARDCAILAQHLIQDFPKVLETAKIPKKVFQEggkypvkMDNWNWMLKGLVKEYEG--VDGLKTGSTPEAGDCFTGTA 272
Cdd:pfam00768 147 YSSARDMAILAKALIKDLPEELSITKEKSFTFRG-------INKINQRNRNGLLWDKTwnVDGLKTGYTNEAGYCLVASA 219
|
250
....*....|..
gi 517613343 273 ERNGMRLISVVI 284
Cdd:pfam00768 220 TKGGMRLISVVM 231
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
13-316 |
4.41e-65 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 212.91 E-value: 4.41e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 13 VTVLTLFCSMFVTYGSASAETGAALNVEAGAAIL----------VEADSGKILYQKNADELLAIASMTKMMSEYLVNEAV 82
Cdd:NF038258 1 IVSLLLLSTIITPPASAAAETPVEIANQEGYQNLseqynpegaiVTTQTGQILYDYHGNKKWDPASMTKLMTMYLTLEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 83 AKGKLKWDQKVKVSE-YAHMiSQDRSLSNVPLENGGSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMNDKAKE 161
Cdd:NF038258 81 KKGKLSLNDKVKITSdYEKM-STLPNLSTFPLKPGQTYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 162 LGLKNYKFVNSTGLTNHDLKGQQPEGTTPDEENKMSARDCAILAQHLIQDFPKVLETAKIPKkvfqeGGKYPVKMDNWNW 241
Cdd:NF038258 160 LGMKHTHFTNPSGADNNLLKPYAPKKYKDETKSKSTAKDMAILSQHLIKKHPKILKYTKLTA-----DTQHGVTLYTTNL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 242 MLKGLVKEYEGVDGLKTGSTPEAGDcFTGTAERNGMRLISVVIKT---NSHTARFDETK---KLFDYGFTNFEVKKVYPK 315
Cdd:NF038258 235 SLPGQPMSLKGTDGLKTGTSDEGYN-LALTTKRDGLRINQVIMNVgpyPSEGAKHARNKianALMERAFKQYEYKKVLSK 313
|
.
gi 517613343 316 G 316
Cdd:NF038258 314 G 314
|
|
| PRK10001 |
PRK10001 |
serine-type D-Ala-D-Ala carboxypeptidase; |
22-439 |
8.29e-51 |
|
serine-type D-Ala-D-Ala carboxypeptidase;
Pssm-ID: 182189 [Multi-domain] Cd Length: 400 Bit Score: 176.72 E-value: 8.29e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 22 MFVTYGSASAETGAALNVEAGAAILVEADSGKILYQKNADELLAIASMTKMMSEYLVNEAVAKGKLKWDQKVKVSEYAHM 101
Cdd:PRK10001 20 LFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 102 ISQD--RSLSNVPLENGGSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMNDKAKELGLKNYKFVNSTGLtnhD 179
Cdd:PRK10001 100 TGNPalRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGL---D 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 180 LKGQQPegttpdeenkmSARDCAILAQHLIQDFPKVLETAKIPKKVFQEggkypVKMDNWNWMlkgLVKEYEGVDGLKTG 259
Cdd:PRK10001 177 APGQFS-----------TARDMALLGKALIHDVPEEYAIHKEKEFTFNK-----IRQPNRNRL---LWSSNLNVDGMKTG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 260 STPEAGDCFTGTAERNGMRLISVVIKTNSHTARFDETKKLFDYGFTNFE-VKKVYPKGSAVkgheTVRVENAKDKDVTIQ 338
Cdd:PRK10001 238 TTAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFEtVTPIKPDATFV----TQRVWFGDKSEVNLG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 339 TKQAIALPMLKGSKDVYKTEFKDVSKDKEAPIKKGTTLGQMIISpkdnndpgfLSGKSL-QVDLITKSEVEKanwfvrsm 417
Cdd:PRK10001 314 AGEAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQ---------LNGKSIeQRPLIVMENVEE-------- 376
|
410 420
....*....|....*....|..
gi 517613343 418 rgiGSFFSGIWNSAVDTVKGWF 439
Cdd:PRK10001 377 ---GGFFSRMWDFVMMKFHQWF 395
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
307-409 |
3.69e-15 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 70.71 E-value: 3.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 307 FEVKKVYPKGSAVKgheTVRVENAKDKDVTIQTKQAIALPMLKGSKDVYKTEFKDVSKDKEAPIKKGTTLGQMIISpkdn 386
Cdd:smart00936 1 FETVKLYKKGQVVG---TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVT---- 73
|
90 100
....*....|....*....|...
gi 517613343 387 nDPGFLSGKslqVDLITKSEVEK 409
Cdd:smart00936 74 -LDGKLIGE---VPLVALEDVEK 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| strep_PBP3 |
NF038273 |
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is ... |
7-415 |
1.53e-127 |
|
streptococcal D-alanyl-D-alanine carboxypeptidase PBP3; PBP3 (penicillin-binding protein 3) is the lone D-alanyl-D-alanine carboxypeptidase in Streptococcus pneumoniae. The gene is known as pbp3 or dacA.
Pssm-ID: 468443 [Multi-domain] Cd Length: 407 Bit Score: 374.98 E-value: 1.53e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 7 KRFIAIVTVLTLFCSMFvtygSASAEtgaALNVEAGAAILVEADSGKILYQKNADELLAIASMTKMMSEYLVNEAVAKGK 86
Cdd:NF038273 1 KKLILLLLLLLAFFLAT----TVSAD---DFDVAAKHAIAVEANTGKILYEKDATTPVPIASLTKLLTAYLVYKEIKSGK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 87 LKWDQKVKVSEYAHMISQDRSLSNVPLENGgSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMNDKAKELGLKN 166
Cdd:NF038273 74 LSWDTPVKISDYPYELTTNYEISNVPLDAR-KYTVKELLEASLVASANSAAIALAEKIAGSEPKFVDKMKAQLKEWGITD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 167 YKFVNSTGLTNHDLKGQQPEGTTPDEENKMSARDCAILAQHLIQDFPKVLETAKIPKKVFqeGGKypvKMDNWNWMLKGL 246
Cdd:NF038273 153 AKLVNASGLNNSYLGDHIYPGSKKDDENKLSAKDVAIIARHLIKDFPEVLKITSKTSADF--AGT---TIYSYNYMLKGM 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 247 VKEYEGVDGLKTGSTPEAGDCFTGTAERNGMRLISVVIKTN----SHTARFDETKKLFDYGFTNFEVKKVYPKGSAVKGh 322
Cdd:NF038273 228 PYYREGVDGLKTGTTEKAGASFVATSVENGMRVITVVLNADnadeDEYARFTATNQLLDYIYQNFEKVTLVKKGQAYKD- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 323 ETVRVENAKDKDVTIQTKQAIALPMLKGSKDVYKTEFKDVSKDKEAPIKKGTTLGQmiISPKDNND--PGFLsGKSLQVD 400
Cdd:NF038273 307 SKLPVIDGKKKTVSAVAKKDLTVIQKIGTDSKPSVKFTPKKKELTAPIKKGQVVGK--ATFKDKDLigKGYL-GEPPSVE 383
|
410 420
....*....|....*....|..
gi 517613343 401 LITKSEVEKANW-------FVR 415
Cdd:NF038273 384 LVAKKDVKKSFFlkvwwnhFVR 405
|
|
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
7-415 |
3.74e-120 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 352.99 E-value: 3.74e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 7 KRFIAIVTVLTLFcsmfvtygSASAETGAALNVEAGAAILVEADSGKILYQKNADELLAIASMTKMMSEYLVNEAVAKGK 86
Cdd:COG1686 2 KKLLLLALLLLLA--------AAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 87 LKWDQKVKVSEYAHMISqdrsLSNVPLENGGSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMNDKAKELGLKN 166
Cdd:COG1686 74 ISLDDKVTVSEEAARTG----GSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 167 YKFVNSTGLtnhdlkgqqpegttPDEENKMSARDCAILAQHLIQDFPKVLETAKIPKKVFQEGGKYpvKMDNWNWMLkgl 246
Cdd:COG1686 150 THFVNPTGL--------------PDPGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNGRGI--TLRNTNRLL--- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 247 vKEYEGVDGLKTGSTPEAGDCFTGTAERNGMRLISVVIKTNSHTARFDETKKLFDYGFtnfevkkvyPKGSAVKghetVR 326
Cdd:COG1686 211 -GRYPGVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYGF---------PKGEALK----AE 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 327 VEnakdkdvtiqtkqaialpmlkgskdvyktefkdVSKDKEAPIKKGTTLGQMIISpkdnndpgfLSGKSL-QVDLITKS 405
Cdd:COG1686 277 VV---------------------------------LDGPLKAPVKKGQVVGTLVVT---------LDGKTIaEVPLVAAE 314
|
410
....*....|
gi 517613343 406 EVEKANWFVR 415
Cdd:COG1686 315 DVEKAGFFSR 324
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
35-284 |
1.54e-89 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 271.57 E-value: 1.54e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 35 AALNVEAGAAILVEADSGKILYQKNADELLAIASMTKMMSEYLVNEAVAKGKLKWDQKVKVSEYAHMISQDRSlSNVPLE 114
Cdd:pfam00768 2 SAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNPGS-SNIFLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 115 NGGSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMNDKAKELGLKNYKFVNSTGLTNHDlkgqqpegttpdeeN 194
Cdd:pfam00768 81 PGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHG--------------Q 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 195 KMSARDCAILAQHLIQDFPKVLETAKIPKKVFQEggkypvkMDNWNWMLKGLVKEYEG--VDGLKTGSTPEAGDCFTGTA 272
Cdd:pfam00768 147 YSSARDMAILAKALIKDLPEELSITKEKSFTFRG-------INKINQRNRNGLLWDKTwnVDGLKTGYTNEAGYCLVASA 219
|
250
....*....|..
gi 517613343 273 ERNGMRLISVVI 284
Cdd:pfam00768 220 TKGGMRLISVVM 231
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
13-316 |
4.41e-65 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 212.91 E-value: 4.41e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 13 VTVLTLFCSMFVTYGSASAETGAALNVEAGAAIL----------VEADSGKILYQKNADELLAIASMTKMMSEYLVNEAV 82
Cdd:NF038258 1 IVSLLLLSTIITPPASAAAETPVEIANQEGYQNLseqynpegaiVTTQTGQILYDYHGNKKWDPASMTKLMTMYLTLEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 83 AKGKLKWDQKVKVSE-YAHMiSQDRSLSNVPLENGGSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMNDKAKE 161
Cdd:NF038258 81 KKGKLSLNDKVKITSdYEKM-STLPNLSTFPLKPGQTYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 162 LGLKNYKFVNSTGLTNHDLKGQQPEGTTPDEENKMSARDCAILAQHLIQDFPKVLETAKIPKkvfqeGGKYPVKMDNWNW 241
Cdd:NF038258 160 LGMKHTHFTNPSGADNNLLKPYAPKKYKDETKSKSTAKDMAILSQHLIKKHPKILKYTKLTA-----DTQHGVTLYTTNL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 242 MLKGLVKEYEGVDGLKTGSTPEAGDcFTGTAERNGMRLISVVIKT---NSHTARFDETK---KLFDYGFTNFEVKKVYPK 315
Cdd:NF038258 235 SLPGQPMSLKGTDGLKTGTSDEGYN-LALTTKRDGLRINQVIMNVgpyPSEGAKHARNKianALMERAFKQYEYKKVLSK 313
|
.
gi 517613343 316 G 316
Cdd:NF038258 314 G 314
|
|
| PRK10001 |
PRK10001 |
serine-type D-Ala-D-Ala carboxypeptidase; |
22-439 |
8.29e-51 |
|
serine-type D-Ala-D-Ala carboxypeptidase;
Pssm-ID: 182189 [Multi-domain] Cd Length: 400 Bit Score: 176.72 E-value: 8.29e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 22 MFVTYGSASAETGAALNVEAGAAILVEADSGKILYQKNADELLAIASMTKMMSEYLVNEAVAKGKLKWDQKVKVSEYAHM 101
Cdd:PRK10001 20 LFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 102 ISQD--RSLSNVPLENGGSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMNDKAKELGLKNYKFVNSTGLtnhD 179
Cdd:PRK10001 100 TGNPalRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGL---D 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 180 LKGQQPegttpdeenkmSARDCAILAQHLIQDFPKVLETAKIPKKVFQEggkypVKMDNWNWMlkgLVKEYEGVDGLKTG 259
Cdd:PRK10001 177 APGQFS-----------TARDMALLGKALIHDVPEEYAIHKEKEFTFNK-----IRQPNRNRL---LWSSNLNVDGMKTG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 260 STPEAGDCFTGTAERNGMRLISVVIKTNSHTARFDETKKLFDYGFTNFE-VKKVYPKGSAVkgheTVRVENAKDKDVTIQ 338
Cdd:PRK10001 238 TTAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFEtVTPIKPDATFV----TQRVWFGDKSEVNLG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 339 TKQAIALPMLKGSKDVYKTEFKDVSKDKEAPIKKGTTLGQMIISpkdnndpgfLSGKSL-QVDLITKSEVEKanwfvrsm 417
Cdd:PRK10001 314 AGEAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQ---------LNGKSIeQRPLIVMENVEE-------- 376
|
410 420
....*....|....*....|..
gi 517613343 418 rgiGSFFSGIWNSAVDTVKGWF 439
Cdd:PRK10001 377 ---GGFFSRMWDFVMMKFHQWF 395
|
|
| PRK10793 |
PRK10793 |
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional |
1-415 |
1.15e-37 |
|
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
Pssm-ID: 182736 [Multi-domain] Cd Length: 403 Bit Score: 141.53 E-value: 1.15e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 1 MKGMFCKRFIAIVTVLTLFCSMFVTYGSASAETGAAL-----NVEAGAAILVEADSGKILYQKNADELLAIASMTKMMSE 75
Cdd:PRK10793 1 MKTIFSARIMKRLALTTALCTAFISAAHADDLNIKTMipgvpQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 76 YLVNEAVAKGKLKWDQKVKVSEYA----HMISQDRSLsnVPLENGGSYTVKELYEAMAIYSANGATIALAEAIAGKEADF 151
Cdd:PRK10793 81 YVIGQAMKAGKFKETDLVTVGNDAwatgNPVFKGSSL--MFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 152 VKMMNDKAKELGLKNYKFVNSTGLtnhDLKGQQPegttpdeenkmSARDCAILAQHLIQDFPKvlETAKIPKKVFQEGGk 231
Cdd:PRK10793 159 VGLMNSYVNALGLKNTHFQTVHGL---DADGQYS-----------SARDMALIGQALIRDVPN--EYAIYKEKEFTFNG- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 232 ypVKMDNWNWML--KGLvkeyeGVDGLKTGSTPEAGDCFTGTAERNGMRLISVVIKTNSHTARFDETKKLFDYGFTNFEV 309
Cdd:PRK10793 222 --IRQLNRNGLLwdNSL-----NVDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGRETESKKLLTWGFRFFET 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 310 KKVYPKGSAVKGH-----ETVRVENAKDKDVTIQTKQAiALPMLKGSKDVYKTEFkdvskdkEAPIKKGTTLGQMIISpk 384
Cdd:PRK10793 295 VNPLKVGKEFASEpvwfgDSDRASLGVDKDVYLTIPRG-RMKDLKASYVLNTSEL-------HAPLQKNQVVGTINFQ-- 364
|
410 420 430
....*....|....*....|....*....|..
gi 517613343 385 dnndpgfLSGKSL-QVDLITKSEVEKANWFVR 415
Cdd:PRK10793 365 -------LDGKTIeQRPLVVLQEIPEGNFFGK 389
|
|
| dacD |
PRK11397 |
serine-type D-Ala-D-Ala carboxypeptidase DacD; |
39-415 |
1.63e-36 |
|
serine-type D-Ala-D-Ala carboxypeptidase DacD;
Pssm-ID: 183117 [Multi-domain] Cd Length: 388 Bit Score: 138.03 E-value: 1.63e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 39 VEAGAAILVEADSGKILYQKNADELLAIASMTKMMSEYLVNEAVAKGKLKWDQKVKVSEYAHmiSQDRSL----SNVPLE 114
Cdd:PRK11397 34 IDAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRITPDDIVTVGRDAW--AKDNPVfvgsSLMFLK 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 115 NGGSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMNDKAKELGLKNYKFVNSTGLtnhDLKGQQPegttpdeen 194
Cdd:PRK11397 112 EGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLHLKDTHFETVHGL---DAPGQHS--------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 195 kmSARDCAILAQHLIQDFPKVLETakipkkvfqeggkYPVKMDNWNWMLK----GLVKEYE-GVDGLKTGSTPEAGDCFT 269
Cdd:PRK11397 180 --SAYDLAVLSRAIIHGEPEFYHM-------------YSEKSLTWNGITQqnrnGLLWDKTmNVDGLKTGHTSGAGFNLI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 270 GTAERNGMRLISVVIKTNSHTARFDETKKLFDYGFTNFEVKKVYPKGSAVkGHEtvRVENAKDKDVTIQTKQAIALPMLK 349
Cdd:PRK11397 245 ASAVDGQRRLIAVVMGADSAKGREEQARKLLRWGQQNFTTVQILHRGKKV-GTE--RIWYGDKENIALGTEQDFWMVLPK 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517613343 350 GSKDVYKTEFKDVSKDKEAPIKKGTTLGQMIISPKDnndpgflsgKSL-QVDLITKSEVEKANWFVR 415
Cdd:PRK11397 322 AEIPHIKAKYVLDGKELEAPISAHQRVGEIELYDRD---------KQVaHWPLVTLESVGEGGMFSR 379
|
|
| pbpG |
PRK11669 |
D-alanyl-D-alanine endopeptidase; Provisional |
7-267 |
2.63e-19 |
|
D-alanyl-D-alanine endopeptidase; Provisional
Pssm-ID: 236952 Cd Length: 306 Bit Score: 87.81 E-value: 2.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 7 KRFIAIVTVLTLFCSMFVTYGSASAETGAA-----LNVEAGAAILVEADSGKILYQKNADELLAIASMTKMMSEYLVNEA 81
Cdd:PRK11669 2 KFRVSLLSLLLLLAGVPFAPQAVAKTAAATtasqpQEIASGSAMVVDLNTNKVIYSSNPDLVVPIASITKLMTAMVVLDA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 82 vakgKLKWDQKVKVSeyahmISQDRSL----SNVPLenGGSYTVKELYEAMAIYSANGATIALAEAIAGKEADFVKMMND 157
Cdd:PRK11669 82 ----KLPLDEKLKVD-----ISQTPEMkgvySRVRL--NSEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMNA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 158 KAKELGLKNYKFVNSTGLTNHdlkgqqpegttpdeeNKMSARDcaiLAQHLI--QDFPKVLETAKIPKK--VFQEGgKYP 233
Cdd:PRK11669 151 KAKALGMTNTRYVEPTGLSIH---------------NVSTARD---LTKLLIasKQYPLIGQLSTTREKtaTFRKP-NYT 211
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 517613343 234 ---------VKMDNWNWMLKglvkeyegvdglKTGSTPEAGDC 267
Cdd:PRK11669 212 lpfrntnhlVYRDNWNIQLT------------KTGFTNAAGHC 242
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
307-409 |
3.69e-15 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 70.71 E-value: 3.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 307 FEVKKVYPKGSAVKgheTVRVENAKDKDVTIQTKQAIALPMLKGSKDVYKTEFKDVSKDKEAPIKKGTTLGQMIISpkdn 386
Cdd:smart00936 1 FETVKLYKKGQVVG---TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVT---- 73
|
90 100
....*....|....*....|...
gi 517613343 387 nDPGFLSGKslqVDLITKSEVEK 409
Cdd:smart00936 74 -LDGKLIGE---VPLVALEDVEK 92
|
|
| PBP5_C |
pfam07943 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
307-409 |
1.27e-13 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 429749 [Multi-domain] Cd Length: 91 Bit Score: 66.08 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 307 FEVKKVYPKGSAVKgheTVRVENAKDKDVTIQTKQAIALPMLKGSKDVYKTEFKdVSKDKEAPIKKGTTLGQMIISpKDN 386
Cdd:pfam07943 1 FETKKLYKKGDVVK---KVKVWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKVT-LKKPLEAPIKKGQVVGKLEVY-LDG 75
|
90 100
....*....|....*....|...
gi 517613343 387 NDPGflsgkslQVDLITKSEVEK 409
Cdd:pfam07943 76 KLIG-------EVPLVAKEDVEE 91
|
|
| PenP |
COG2367 |
Beta-lactamase class A [Defense mechanisms]; |
35-211 |
3.88e-11 |
|
Beta-lactamase class A [Defense mechanisms];
Pssm-ID: 441934 [Multi-domain] Cd Length: 276 Bit Score: 63.38 E-value: 3.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 35 AALNVEAGAAILvEADSGKILYQkNADELLAIASMTKMMSEYLVNEAVAKGKLKWDQKVKVSEyahmisQDRSL-SNV-- 111
Cdd:COG2367 29 AALGGRVGVYVL-DLDTGETVGI-NADERFPAASTFKLPVLAAVLRQVDAGKLSLDERVTLTP------EDLVGgSGIlq 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 112 PLENGGSYTVKELYEAMAIYSANGATIALAEAIaGKEAdfvkmMNDKAKELGLKNYKFVNSTGLTNHDLkgqqpegttPD 191
Cdd:COG2367 101 KLPDGTGLTLRELAELMITVSDNTATNLLLRLL-GPDA-----VNAFLRSLGLTDTRLDRKEPDLNELP---------GD 165
|
170 180
....*....|....*....|
gi 517613343 192 EENKMSARDCAILAQHLIQD 211
Cdd:COG2367 166 GRNTTTPRDMARLLAALYRG 185
|
|
| Beta-lactamase2 |
pfam13354 |
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ... |
59-211 |
2.00e-08 |
|
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.
Pssm-ID: 463854 [Multi-domain] Cd Length: 215 Bit Score: 54.59 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 59 NADELLAIASMTKMMSEYLVNEAVAKGKLKWDQKVKVSE-----YAHMISqdrslsnvPLENGGSYTVKELYEAMAIYSA 133
Cdd:pfam13354 16 NGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTAedkvgGSGILQ--------YLPDGSQLSLRDLLTLMIAVSD 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517613343 134 NGATIALAEaIAGKEAdfvkmMNDKAKELGLKNykfvnstglTNHDLKGQQPEGTTPDEENKMSARDCAILAQHLIQD 211
Cdd:pfam13354 88 NTATNLLID-RLGLEA-----VNARLRALGLRD---------TRLRRKLPDLRAADKGGTNTTTARDMAKLLEALYRG 150
|
|
| AmpC |
COG1680 |
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms]; |
42-211 |
4.51e-06 |
|
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];
Pssm-ID: 441286 [Multi-domain] Cd Length: 355 Bit Score: 48.53 E-value: 4.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 42 GAAILVeADSGKILYQK-------------NADELLAIASMTKMMSEYLVNEAVAKGKLKWDQkvKVSEY---------- 98
Cdd:COG1680 34 GAAVAV-VRDGKVVYEKaygvadletgrpvTPDTLFRIASVTKSFTATAVLQLVEEGKLDLDD--PVSKYlpefklpdda 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517613343 99 ------AHMISQ------DRSLSNVPLENGGSYTVKELYEAMA------------IYSaNGATIALAEAIA---GKE-AD 150
Cdd:COG1680 111 krditvRHLLTHtsglpdYEPDPYDAADVARPYTPDDLLARLAalpllfepgtrfSYS-NLGYDLLGEIIErvtGQPlED 189
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517613343 151 FVKmmnDK-AKELGLKNYKFVNSTGLTNHDLKGQQPEGTTPDEENKM-----------SARDCAILAQHLIQD 211
Cdd:COG1680 190 YLR---ERiFEPLGMTDTGFGLPDAEAARLAPGYEADGEVHDAPAWLgavagagglfsTARDLARFGQALLNG 259
|
|
| |
