|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
1-354 |
4.53e-84 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 259.87 E-value: 4.53e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 1 MKRGLQFRLSLLLIGVASGILLIAGISFMAGTHYHFRLYQDQYGMDHSLPGLAYHLEQALLQSMMWTLVGAVLLSIMISL 80
Cdd:COG5002 22 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLAL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 81 YVAKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDEL------ADLGKALNHLAEQLQKQEKLRVTMTQDIAHELRTPLA 154
Cdd:COG5002 102 LILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLsalllgLLLLAAVERDITELERLEQMRREFVANVSHELRTPLT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 155 TLKSHMQAMLDQIWDPTPAR---LRACYEETERLIALVADLEQLTVMDSPHFRLQRKPEDLSTLIQQSLGIVAAAFMEKG 231
Cdd:COG5002 182 SIRGYLELLLDGAADDPEERreyLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 232 VRLDV-MPHLSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVD 310
Cdd:COG5002 262 IELELdLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVD 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 517837428 311 KSRNRKMGGAGIGLTIVKKLVEAHGGTVWIES--DKGTTVYLRFPK 354
Cdd:COG5002 342 KSRSRETGGTGLGLAIVKHIVEAHGGRIWVESepGKGTTFTITLPL 387
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
123-354 |
5.22e-72 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 224.02 E-value: 5.22e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 123 ALNHLAEQLQKQEKLRVTMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPAR---LRACYEETERLIALVADLEQLTVMD 199
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERrelLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 200 SPHFRLQRKPEDLSTLIQQSLGIVAAAFMEKGVRLDV-MPHLSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQD 278
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELdLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517837428 279 ENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRkmGGAGIGLTIVKKLVEAHGGTVWIES--DKGTTVYLRFPK 354
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESepGGGTTFTVTLPL 236
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
56-354 |
1.25e-66 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 213.23 E-value: 1.25e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 56 LEQALLQSMMWTLVGAVLLSIMISLYVAKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQLQKQE 135
Cdd:COG0642 28 LLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEAN 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 136 KLRVTMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPARLRACYEETERLIALVADLEQLTVMDSPHFRLQRKPEDLSTL 215
Cdd:COG0642 108 EAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAEL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 216 IQQSLGIVAAAFMEKGVRLDV-MPHLSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGI 294
Cdd:COG0642 188 LEEVVELFRPLAEEKGIELELdLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGI 267
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517837428 295 APNDLPYVFERFYRVDKSRNRkmGGAGIGLTIVKKLVEAHGGTVWIES--DKGTTVYLRFPK 354
Cdd:COG0642 268 PPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESepGKGTTFTVTLPL 327
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
62-338 |
3.45e-60 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 200.05 E-value: 3.45e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 62 QSMMWTLVGAV--LLSIMISLYVAKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQLQKQEKLRV 139
Cdd:NF012163 162 QKRASWLIVALalLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRR 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 140 TMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPARLRACYEETERLIALVADLEQLTVMDSPHFRLQRKPEDLSTLIQQS 219
Cdd:NF012163 242 DFMADISHELRTPLAVLRAELEAIQDGIRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVE 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 220 LGIVAAAFMEKGVRLDVMPHLSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDL 299
Cdd:NF012163 322 GGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQL 401
|
250 260 270
....*....|....*....|....*....|....*....
gi 517837428 300 PYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTV 338
Cdd:NF012163 402 ARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTL 440
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
66-338 |
2.20e-59 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 198.32 E-value: 2.20e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 66 WTLVG-AVLLSIMISLYVAKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQLQKQEKLRVTMTQD 144
Cdd:PRK10549 167 WLIVAlSTLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMAD 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 145 IAHELRTPLATLKSHMQAMLDQIWDPTPARLRACYEETERLIALVADLEQLTVMDSPHFRLQRKPEDLSTLIQQSLGIVA 224
Cdd:PRK10549 247 ISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFR 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 225 AAFMEKGVRLDVMPHLSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFE 304
Cdd:PRK10549 327 ERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFE 406
|
250 260 270
....*....|....*....|....*....|....
gi 517837428 305 RFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTV 338
Cdd:PRK10549 407 RFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRI 440
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
147-349 |
8.86e-59 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 199.59 E-value: 8.86e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 147 HELRTPLATLKSHMQAMLDQIW-DPTPAR--LRACYEETERLIALVADLEQLTVMDSPHFRLQRKPEDLSTLIQQslgiV 223
Cdd:NF033092 381 HELRTPLTTMRSYLEALADGAWkDPELAPrfLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNY----I 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 224 AAAF-M---EKGVRLDV-MPHLSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPND 298
Cdd:NF033092 457 IDRFeMilkNKNITFKReFPKRDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKD 536
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 517837428 299 LPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIES--DKGTTVY 349
Cdd:NF033092 537 LDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAESeeGKGTTIY 589
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
55-353 |
5.63e-52 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 178.74 E-value: 5.63e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 55 HLEQALLQSMMWTLVGAVLLSIMISLYVAKRLSAPLVEMKNAAEQITRGKLTVRTSI-RGNDELADLGKALNHLAEQL-- 131
Cdd:TIGR01386 157 HLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPsRAPAELRELAQSFNAMLGRLed 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 132 --QKQEKLrvtmTQDIAHELRTPLATLKSHMQAMLDQiwDPTPARLRACY----EETERLIALVADLEQLTVMDSPHFRL 205
Cdd:TIGR01386 237 afQRLSQF----SADLAHELRTPLTNLLGQTQVALSQ--PRTGEEYREVLesnlEELERLSRMVSDMLFLARADNGQLAL 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 206 QRKPEDLSTLIQQSLGIVAAAFMEKGVRLDVmpHLSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLI 285
Cdd:TIGR01386 311 ERVRLDLAAELAKVAEYFEPLAEERGVRIRV--EGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRV 388
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517837428 286 AIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIESDKGTTVY-LRFP 353
Cdd:TIGR01386 389 SVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFiLRFP 457
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
130-352 |
3.76e-46 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 160.07 E-value: 3.76e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 130 QLQKQEKLRVTMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPAR---LRACYEETERLIALVADLEQLTVMDSPHFRLQ 206
Cdd:TIGR02966 106 RLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWnraLEIMLEQSQRMQSLVEDLLTLSRLESAASPLE 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 207 RKPEDLSTLIQQSLGIVAAAFMEKGVRLDVMPHLSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIA 286
Cdd:TIGR02966 186 DEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFS 265
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517837428 287 IQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIESD--KGTTVYLRF 352
Cdd:TIGR02966 266 VTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESElgKGSTFSFIF 333
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
67-354 |
5.53e-46 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 162.05 E-value: 5.53e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 67 TLVGAVLLSIMISLYVAKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQLQKQ------------ 134
Cdd:COG5000 14 IALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQreeleerrryle 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 135 --------------------------------------------------------------------------EKLRVT 140
Cdd:COG5000 94 tilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrRTLLVR 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 141 MT-----------QDI-------------------AHELRTPLA-------TLKSHMQAMLDQIWDPTPARLRACYEETE 183
Cdd:COG5000 174 ASplrddgyvivfDDItellraerlaawgelarriAHEIKNPLTpiqlsaeRLRRKLADKLEEDREDLERALDTIIRQVD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 184 RLIALVADLEQLTVMDSPhfrlQRKPEDLSTLIQQSLGIVAAAFMEKGVRLDV-MPHLSVRLHVDRDRFIQVLVNVLTNA 262
Cdd:COG5000 254 RLKRIVDEFLDFARLPEP----QLEPVDLNELLREVLALYEPALKEKDIRLELdLDPDLPEVLADRDQLEQVLINLLKNA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 263 LKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYrvdksrNRKMGGAGIGLTIVKKLVEAHGGTVWIES 342
Cdd:COG5000 330 IEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELES 403
|
410
....*....|....
gi 517837428 343 --DKGTTVYLRFPK 354
Cdd:COG5000 404 rpGGGTTFTIRLPL 417
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
66-349 |
1.99e-43 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 153.61 E-value: 1.99e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 66 WTLVGAVLL-----SIMISLYVAKRLSAPLVEMKNAAEQITRGKLtvrtSIRGND------ELADLGKALNHLAEQLQKQ 134
Cdd:NF012226 59 WIWLFTVILcgsviSLIIGMKLAQRFIVPINFLADAAKKISQGDL----SARAEDsqihsaEISELMHNFNDMAQKLESS 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 135 EKLRVTMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPARLRACYEETERLIALVADLEQLTVMDSPHFRLQRKPEDLST 214
Cdd:NF012226 135 VKNAQVWNAAIAHELRTPITILQGRLQGILDGVFEPDPALFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKD 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 215 LIQQSLGIVAAAFMEKGVRLDV-MPHLSVrlHVDRDRFIQVLVNVLTNALKFTpEKGQVKIQVQDENDTVLIAIQDTGTG 293
Cdd:NF012226 215 SIEKVLKMFEDRLEQAQLTIVLnLTATPV--FCDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQIEDEGPG 291
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 517837428 294 IAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIESDKGTTVY 349
Cdd:NF012226 292 IAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQGNSVF 347
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
68-354 |
1.13e-42 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 154.80 E-value: 1.13e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 68 LVGAVLLSIM--ISLYVAKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQLQKQ-------EKLR 138
Cdd:NF040691 192 LGGLALVVLLglIAWLVTRQVVAPVRSAARTAERFAAGDLSERMPVKGEDDLARLARSFNQMADSLQRQirqleelSRLQ 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 139 VTMTQDIAHELRTPLATLKshMQAmlDQIW------DPTPAR----LRacyEETERLIALVADLEQLTVMDSPHFRLQRK 208
Cdd:NF040691 272 QRFVSDVSHELRTPLTTIR--MAA--DVIHdsrddfDPATARsaelLH---TELDRFESLLSDLLEISRFDAGAAELDVE 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 209 PEDLSTLIQQSLGIVAAAFMEKGVRLDV-MPHLSVRLHVDRDRFIQVLVNVLTNALKFTpEKGQVKIQVQDENDTVLIAI 287
Cdd:NF040691 345 PVDLRPLVRRVVDALRQLAERAGVELRVdAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAVAVTV 423
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517837428 288 QDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGT--VWIESDKGTTVYLRFPK 354
Cdd:NF040691 424 RDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWleAWGRPGQGSQFRLTLPR 492
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
55-354 |
1.68e-41 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 151.08 E-value: 1.68e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 55 HLEQALLQSMMWTLVGAVLLSIMISLYVAKRLSAPLVEMKNAAEQITRGKLTVRTS-IRGNDELADLGKALNHLAEQLQK 133
Cdd:PRK09835 178 HYINDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDpQTVPIELEQLVLSFNHMIERIED 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 134 QEKLRVTMTQDIAHELRTPLATLKSHMQAMLDQiwDPTPARLR----ACYEETERLIALVADLEQLTVMDSPHFRLQRKP 209
Cdd:PRK09835 258 VFTRQSNFSADIAHEIRTPITNLITQTEIALSQ--SRSQKELEdvlySNLEELTRMAKMVSDMLFLAQADNNQLIPEKKM 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 210 EDLSTLIQQSLGIVAAAFMEKGV--RLDVMPHLsvrlhVDRD--RFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLI 285
Cdd:PRK09835 336 LDLADEVGKVFDFFEAWAEERGVelRFVGDPCQ-----VAGDplMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQL 410
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 286 AIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIESD-KGTTVYLRFPK 354
Cdd:PRK09835 411 VVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDaRGTRFVISLPR 480
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
5-353 |
2.63e-41 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 148.02 E-value: 2.63e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 5 LQFRLSLLLIGVASGILLIAGISFMAGTHYHFRLYQDQYGMDHSLPGLAYHLEQALLQSMMWTLVGAVLLSIMISLYVAK 84
Cdd:COG4191 9 LLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 85 RLSAPLVEMKNAAEQITRGKLtvRTSIRGNDELADLGKALNHLAEQLQKQEKLRV--TMTQDIAHELRTPLATLKS---H 159
Cdd:COG4191 89 LLEALLLLLLAALDAEENAEL--EELERDITELERAEEELRELQEQLVQSEKLAAlgELAAGIAHEINNPLAAILGnaeL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 160 MQAMLDQIWDPTPAR--LRACYEETERLIALVADLEQLTVMDSPhfrlQRKPEDLSTLIQQSLGIVAAAFMEKGVRL--D 235
Cdd:COG4191 167 LRRRLEDEPDPEELReaLERILEGAERAAEIVRSLRAFSRRDEE----EREPVDLNELIDEALELLRPRLKARGIEVelD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 236 VMPHLsVRLHVDRDRFIQVLVNVLTNALKFTPEK--GQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFY---RVD 310
Cdd:COG4191 243 LPPDL-PPVLGDPGQLEQVLLNLLINAIDAMEEGegGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttkPVG 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 517837428 311 KsrnrkmgGAGIGLTIVKKLVEAHGGTVWIES--DKGTTVYLRFP 353
Cdd:COG4191 322 K-------GTGLGLSISYGIVEKHGGRIEVESepGGGTTFTITLP 359
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
247-354 |
5.01e-40 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 137.01 E-value: 5.01e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 247 DRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKsRNRKMGGAGIGLTI 326
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|
gi 517837428 327 VKKLVEAHGGTVWIES--DKGTTVYLRFPK 354
Cdd:smart00387 81 VKKLVELHGGEISVESepGGGTTFTITLPL 110
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
90-342 |
6.98e-39 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 143.21 E-value: 6.98e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 90 LVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQLQKQEKLRVTMTQDIAHELRTPLATLKSHMqAMLDqiwD 169
Cdd:PRK10604 164 MLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRL-EMSD---N 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 170 PTPARLRACYEETERLIALVADLEQLTVMDSPHFRLQRKPEDLSTLIQQSLGIVAAAFMEKGVRLDvMPHLSVRLHVDRD 249
Cdd:PRK10604 240 LSAAESQALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLD-TPHQGDYGALDMR 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 250 RFIQVLVNVLTNALKFTpeKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKK 329
Cdd:PRK10604 319 LMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHS 396
|
250
....*....|...
gi 517837428 330 LVEAHGGTVWIES 342
Cdd:PRK10604 397 IALAMGGSVNCDE 409
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
3-354 |
1.03e-36 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 138.38 E-value: 1.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 3 RGLQFRLSLLLIGVASGILLIAGISFMAGTHYHFRLYQDQYGMDHSLPGLAYHLEQALLQSMMWTLVGAVLLSIMISLYV 82
Cdd:COG4251 147 LALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLG 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 83 AKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQLQKQEKLRVTMTQDIAHELRTPLATLKSHMQA 162
Cdd:COG4251 227 LLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQL 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 163 MLDQIWDPTPARLRACYE----ETERLIALVADLEQLTVMDSPHfrLQRKPEDLSTLIQQSLGIVAAAFMEKGVRLDVMP 238
Cdd:COG4251 307 LEEDYGDKLDEEGREYLErirdAAERMQALIDDLLAYSRVGRQE--LEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGP 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 239 HLSVRlhVDRDRFIQVLVNVLTNALKFTP--EKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDksRNRK 316
Cdd:COG4251 385 LPTVR--GDPTLLRQVFQNLISNAIKYSRpgEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDE 460
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 517837428 317 MGGAGIGLTIVKKLVEAHGGTVWIES--DKGTTVYLRFPK 354
Cdd:COG4251 461 YEGTGIGLAIVKKIVERHGGRIWVESepGEGATFYFTLPK 500
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
251-352 |
2.48e-36 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 126.95 E-value: 2.48e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 251 FIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRkmGGAGIGLTIVKKL 330
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 517837428 331 VEAHGGTVWIES--DKGTTVYLRF 352
Cdd:cd00075 79 VEAHGGRITVESepGGGTTFTVTL 102
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
251-353 |
1.89e-34 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 122.60 E-value: 1.89e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 251 FIQVLVNVLTNALKFTPEkGQVKIQVQ-----DENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLT 325
Cdd:cd16922 1 LRQILLNLLGNAIKFTEE-GEVTLRVSleeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 517837428 326 IVKKLVEAHGGTVWIES--DKGTTVYLRFP 353
Cdd:cd16922 80 ISKKLVELMGGDISVESepGQGSTFTFTLP 109
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
247-353 |
9.13e-34 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 120.55 E-value: 9.13e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 247 DRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDEnDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKsrnRKMGGAGIGLTI 326
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSI 77
|
90 100
....*....|....*....|....*....
gi 517837428 327 VKKLVEAHGGTVWIES--DKGTTVYLRFP 353
Cdd:pfam02518 78 VRKLVELLGGTITVESepGGGTTVTLTLP 106
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
126-353 |
2.44e-33 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 126.50 E-value: 2.44e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 126 HLAEQLQKQEKLRV--TMTQDIAHELRTPLATLKSHMQAMLDQI-WDPTPARLRACYEETERLIALVADLEQLTVMDSPH 202
Cdd:COG3852 121 RLERELRRAEKLAAvgELAAGLAHEIRNPLTGIRGAAQLLERELpDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPE 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 203 frlqRKPEDLSTLIQQSLGIVAAAFmEKGVRL--DVMPHLSvRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQV---- 276
Cdd:COG3852 201 ----REPVNLHEVLERVLELLRAEA-PKNIRIvrDYDPSLP-EVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTrver 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 277 ------QDENDTVLIAIQDTGTGIAPNDLPYVFERFYRvdksrnRKMGGAGIGLTIVKKLVEAHGGTVWIES--DKGTTV 348
Cdd:COG3852 275 qvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFT------TKEKGTGLGLAIVQKIVEQHGGTIEVESepGKGTTF 348
|
....*
gi 517837428 349 YLRFP 353
Cdd:COG3852 349 RIYLP 353
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
62-354 |
1.30e-32 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 126.88 E-value: 1.30e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 62 QSMMWTLVGAVLLSIMISLYVAKRLSAPLVEMKNAAEQITRGKlTVRTSIRGNDELADLGKALNHLAEQLQ-KQ--EKLR 138
Cdd:PRK11100 182 RRILWAGALLLGIALLIGAGVVWWLNRSIRRLTRYADAVTEGK-PVPLPKLGSSELRELAQALESMRVKLEgKAyvEQYV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 139 VTMTqdiaHELRTPLATLKShmQAMLDQiwDPTPARLRACY-----EETERLIALVADLEQLTVMDSPHFRLQRKPEDLS 213
Cdd:PRK11100 261 QTLT----HELKSPLAAIRG--AAELLQ--EDPPPEDRARFtgnilTQSARLQQLIDRLLELARLEQRQELEVLEPVALA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 214 TLIQQSLGIVAAAFMEKGVRLDVMPhlsVRLHVDRDRFI--QVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTG 291
Cdd:PRK11100 333 ALLEELVEAREAQAAAKGITLRLRP---DDARVLGDPFLlrQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQG 409
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517837428 292 TGIAPNDLPYVFERFY---RVDKSRNrkmgGAGIGLTIVKKLVEAHGGTVWIES--DKGTTVYLRFPK 354
Cdd:PRK11100 410 PGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNrpEGGVLATLTLPR 473
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
126-354 |
2.35e-32 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 126.24 E-value: 2.35e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 126 HLAEQLQKQEKLRVT--MTQDIAHELRTPLATLKSHMQAMLDQIWDPtparlRACY-----EETERLIALVADLEQLTVM 198
Cdd:COG5809 256 KLEELLRKSEKLSVVgeLAAGIAHEIRNPLTSLKGFIQLLKDTIDEE-----QKTYldimlSELDRIESIISEFLVLAKP 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 199 DSPHFrlqrKPEDLSTLIQQSLGIVAAAFMEKGVrldvmphlSVRLHVDRD---------RFIQVLVNVLTNALKFTPEK 269
Cdd:COG5809 331 QAIKY----EPKDLNTLIEEVIPLLQPQALLKNV--------QIELELEDDipdilgdenQLKQVFINLLKNAIEAMPEG 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 270 GQVKIQVQDENDT-VLIAIQDTGTGIAPNDLPYVFERFYrvdksrNRKMGGAGIGLTIVKKLVEAHGGTVWIES--DKGT 346
Cdd:COG5809 399 GNITIETKAEDDDkVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESevGKGT 472
|
....*...
gi 517837428 347 TVYLRFPK 354
Cdd:COG5809 473 TFSITLPI 480
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
247-353 |
4.21e-31 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 113.71 E-value: 4.21e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 247 DRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTI 326
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 517837428 327 VKKLVEAHGGTVWIESDK--GTTVYLRFP 353
Cdd:cd16946 81 CHNIALAHGGTISAEHSPlgGLRLVLTLP 109
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
127-353 |
4.55e-28 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 115.07 E-value: 4.55e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 127 LAEQLQKQEKLRV--TMTQDIAHELRTPLATLKSHMQAMLDQIWD-PTPARLRACYEETERLIALVadlEQLTVMDSPHf 203
Cdd:PRK11360 377 LQRRVARQERLAAlgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDpPSQEYLSVVLREVDRLNKVI---DQLLEFSRPR- 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 204 RLQRKPEDLSTLIQQSLGIVAAAFMEKGVRLDVmpHLSVRL---HVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDEN 280
Cdd:PRK11360 453 ESQWQPVSLNALVEEVLQLFQTAGVQARVDFET--ELDNELppiWADPELLKQVLLNILINAVQAISARGKIRIRTWQYS 530
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517837428 281 DT-VLIAIQDTGTGIAPNDLPYVFERFYrvdksrNRKMGGAGIGLTIVKKLVEAHGGTVWIESD--KGTTVYLRFP 353
Cdd:PRK11360 531 DGqVAVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEpgVGTTFTLYLP 600
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
111-345 |
1.73e-27 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 111.20 E-value: 1.73e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 111 IRGNDELADLGKALNHLAEQLQKQEKLrVTMtqdIAHELRTPLA-------TLKS--------HMQAMLDQIWDPTPARL 175
Cdd:PRK09303 128 LQLSDELFVLRQENETLLEQLKFKDRV-LAM---LAHDLRTPLTaaslaleTLELgqidedteLKPALIEQLQDQARRQL 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 176 RacyeETERLIAlvaDLEQLTVMDSPHFRLQRKPEDLSTLIQQSLGIVAAAFMEKGVRL--DVMPHLSvRLHVDRDRFIQ 253
Cdd:PRK09303 204 E----EIERLIT---DLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIqtDIPSDLP-SVYADQERIRQ 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 254 VLVNVLTNALKFTPEKGQVKIQVQDE-NDTVLIAIQDTGTGIAPNDLPYVFERFYRVdkSRNRKMGGAGIGLTIVKKLVE 332
Cdd:PRK09303 276 VLLNLLDNAIKYTPEGGTITLSMLHRtTQKVQVSICDTGPGIPEEEQERIFEDRVRL--PRDEGTEGYGIGLSVCRRIVR 353
|
250
....*....|...
gi 517837428 333 AHGGTVWIESDKG 345
Cdd:PRK09303 354 VHYGQIWVDSEPG 366
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
66-341 |
3.80e-27 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 111.18 E-value: 3.80e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 66 WTLVGAVLL-SIMISLYVAKRLSAPLVEMKNAAEQITRGKLTVRTSI-RGNDELADLGKALNHLAEQLQkqeklRVTMTQ 143
Cdd:PRK09470 169 LLLLLVTMLvSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELeTGPQEFRQAGASFNQMVTALE-----RMMTSQ 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 144 -----DIAHELRTPLATLksHM-QAML--DQIWDPTPARLRAcyeETERLIALVADLEQLTVMDSpHFRLQRKPEDLSTL 215
Cdd:PRK09470 244 qrllsDISHELRTPLTRL--QLaTALLrrRQGESKELERIET---EAQRLDSMINDLLVLSRNQQ-KNHLERETFKANSL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 216 IQQSL--GIVAAAFMEKgvrldvmpHLSVRLHVDRdRFI--------QVLVNVLTNALKFTpeKGQVKIQVQDENDTVLI 285
Cdd:PRK09470 318 WSEVLedAKFEAEQMGK--------SLTVSAPPGP-WPIngnpnalaSALENIVRNALRYS--HTKIEVAFSVDKDGLTI 386
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 517837428 286 AIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIE 341
Cdd:PRK09470 387 TVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAE 442
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
58-353 |
7.07e-27 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 112.04 E-value: 7.07e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 58 QALLQSMMWTLVGAVLLSIMISLYVAKRLSAPL---VEMKNAAEQITrgkLTVRTSIRGNDELADLGKALNHLAEQLQKQ 134
Cdd:PRK15347 293 KPALQQLPFALLILVLLTSVLFLLLRRYLAKPLwrfVDIINKTGPAA---LEPRLPENRLDELGSIAKAYNQLLDTLNEQ 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 135 ----EKlRVTM-TQ---------------------DIAHELRTPLATLKSHMQAMLDQIWDPTPARL----RACyeeTER 184
Cdd:PRK15347 370 ydtlEN-KVAErTQalaeakqraeqankrksehltTISHEIRTPLNGVLGALELLQNTPLTAEQMDLadtaRQC---TLS 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 185 LIALVADLEQLTVMDSPHFRLQRKPEDLSTLIQQSLGIVAAAFMEKGVRLD--VMPHLSVRLHVDRDRFIQVLVNVLTNA 262
Cdd:PRK15347 446 LLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRtfVGAHVPLYLHLDSLRLRQILVNLLGNA 525
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 263 LKFTpEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSrnrkMGGAGIGLTIVKKLVEAHGG--TVWI 340
Cdd:PRK15347 526 VKFT-ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIASSLAKMMGGelTLFS 600
|
330
....*....|...
gi 517837428 341 ESDKGTTVYLRFP 353
Cdd:PRK15347 601 TPGVGSCFSLVLP 613
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
129-354 |
1.25e-26 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 110.21 E-value: 1.25e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 129 EQLQKQEKLRVT--MTQDIAHELRTPLATLKSHMQAMLdqiwdPTPARLRACY----EETERLIALVADLEQLTVMDSPH 202
Cdd:COG5805 276 ELMARSEKLSIAgqLAAGIAHEIRNPLTSIKGFLQLLQ-----PGIEDKEEYFdimlSELDRIESIISEFLALAKPQAVN 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 203 FrlqrKPEDLSTLIQQslgivAAAFMEKGVRLD----VMPHL--SVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQV 276
Cdd:COG5805 351 K----EKENINELIQD-----VVTLLETEAILHniqiRLELLdeDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHT 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 277 QDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSrnrkmgGAGIGLTIVKKLVEAHGGTVWIES--DKGTTVYLRFPK 354
Cdd:COG5805 422 EEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSkvGKGTTFTITLPL 495
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
127-353 |
1.28e-26 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 109.88 E-value: 1.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 127 LAEQLQKQEKLRV--TMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPARLRA--CYEETERLIALVADLEQLTvmDSPH 202
Cdd:PRK10364 224 LQDEMKRKEKLVAlgHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAqvMAKEADRLNRVVSELLELV--KPTH 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 203 FRLQrkPEDLSTLIQQSLGIVAAAFMEKGVRLDVMPHLSV-RLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDEND 281
Cdd:PRK10364 302 LALQ--AVDLNDLINHSLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGA 379
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517837428 282 TVLIAIQDTGTGIAPNDLPYVFERFYrvdksrNRKMGGAGIGLTIVKKLVEAHGGTVWIESD--KGTTVYLRFP 353
Cdd:PRK10364 380 GVKISVTDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQegKGATFTLWLP 447
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
130-354 |
2.34e-25 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 105.86 E-value: 2.34e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 130 QLQKQEKLRVTMTQDIAHELRTPLATLKSHMQAMLDQIWDpTPARLRACY---EETERLIALVADLEQLTVMD-SPHFRL 205
Cdd:PRK11006 196 QMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLE-GALREKALHtmrEQTQRMEGLVKQLLTLSKIEaAPTIDL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 206 QRK---PEDLSTLIQQSlgiVAAAFMEKGVRLDVMPHLSVRlhVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDT 282
Cdd:PRK11006 275 NEKvdvPMMLRVLEREA---QTLSQGKHTITFEVDNSLKVF--GNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQG 349
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517837428 283 VLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIES--DKGTTVYLRFPK 354
Cdd:PRK11006 350 AEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESevGKGTRFSFVLPE 423
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-354 |
3.14e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 95.09 E-value: 3.14e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 253 QVLVNVLTNALKFTPEKgqVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVE 332
Cdd:cd16949 3 RALENVLRNALRYSPSK--ILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 517837428 333 AHGGTVWIESDK--GTTVYLRFPK 354
Cdd:cd16949 81 QHGGKIKASNRKpgGLRVRIWLPA 104
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
52-353 |
4.80e-24 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 103.23 E-value: 4.80e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 52 LAYHLEQALLQSMMWtLVGAVLLSIMIS-----LYVAKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKAL-- 124
Cdd:COG4192 313 LNQETAQLVQQSGIL-LLAIALLSLLLAvlinyFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLrv 391
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 125 -----NHLAEQLQ------------------------KQEKLRVTMTQdIAHELRTPLATLKSHMQAMLDQIWDPTPARL 175
Cdd:COG4192 392 frdqaIEKTQELEteieerkrieknlrqtqdeliqaaKMAVVGQTMTS-LAHELNQPLNAMSMYLFSAKKALEQENYAQL 470
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 176 RACYEETERLIA----LVADLEQLTVMDSPHFrlqrKPEDLSTLIQQSLGIVAAAFMEKGVRLDVMPHLSVRlhVDRDRF 251
Cdd:COG4192 471 PTSLDKIEGLIErmdkIIKSLRQFSRKSDTPL----QPVDLRQVIEQAWELVESRAKPQQITLHIPDDLMVQ--GDQVLL 544
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 252 IQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIApnDLPYVFERFYrvdksrNRKMGGAGIGLTIVKKLV 331
Cdd:COG4192 545 EQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFT------TTKEVGLGLGLSICRSIM 616
|
330 340
....*....|....*....|....
gi 517837428 332 EAHGGTVWIES--DKGTTVYLRFP 353
Cdd:COG4192 617 QQFGGDLYLAStlERGAMVILEFN 640
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-349 |
1.76e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 93.22 E-value: 1.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 254 VLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNrkMGGAGIGLTIVKKLVEA 333
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAIIEL 81
|
90
....*....|....*.
gi 517837428 334 HGGTVWIESDKGTTVY 349
Cdd:cd16923 82 HGGSASAEYDDNHDLF 97
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
247-340 |
2.46e-23 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 92.94 E-value: 2.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 247 DRDRFIQVLVNVLTNALKFTPEKGQVKIQVQ-DENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLT 325
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90
....*....|....*
gi 517837428 326 IVKKLVEAHGGTVWI 340
Cdd:cd16925 81 IVKEFVELHGGTVTV 95
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-353 |
3.03e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 92.65 E-value: 3.03e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 257 NVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGG 336
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 517837428 337 TVWIESD--KGTTVYLRFP 353
Cdd:cd16952 87 RLLIASElgKGSRFTCLFP 105
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
73-338 |
1.22e-22 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 98.06 E-value: 1.22e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 73 LLSIMISLYVAKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQLQKQEKLRVTMTQDIAHELRTP 152
Cdd:PRK09467 164 LLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTP 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 153 LAT--LKSHMQAmldqiwdptparlracyEETERLI-ALVADLEQltvMDS----------PHFRLQRKPEDLSTLIQQs 219
Cdd:PRK09467 244 LTRirLATEMMS-----------------EEDGYLAeSINKDIEE---CNAiieqfidylrTGQEMPMEMADLNALLGE- 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 220 lgiVAAAFM--EKGVRLDVMPHlSVRLHVDRDRFIQVLVNVLTNALKFTpeKGQVKIQVQDENDTVLIAIQDTGTGIAPN 297
Cdd:PRK09467 303 ---VIAAESgyEREIETALQPG-PIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVEDDGPGIPPE 376
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 517837428 298 DLPYVFERFYRVDKSRNRKmgGAGIGLTIVKKLVEAHGGTV 338
Cdd:PRK09467 377 QLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKV 415
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
124-354 |
1.16e-21 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 94.92 E-value: 1.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 124 LNHLAEQLQKQEKLrVTMTQDIAHELRTPLATLKSHMQamLDQiwdptparlracYEETERLI-ALVADLEQLTVMDSPH 202
Cdd:COG3290 176 LERLEEELEGVKEL-AEALRAQRHDFRNHLHTISGLLQ--LGE------------YDEALEYIdEISEELQELIDSLLSR 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 203 FrlqrKPEDLSTLIqqsLGIVAAAfMEKGVRLDVMPHLSVR-LHVDRDRFIQVLVNVLTNAL----KFTPEKGQVKIQVQ 277
Cdd:COG3290 241 I----GNPVLAALL---LGKAARA-RERGIDLTIDIDSDLPdLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIR 312
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517837428 278 DENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRkmggaGIGLTIVKKLVEAHGGTVWIESD--KGTTVYLRFPK 354
Cdd:COG3290 313 DDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLGEGR-----GLGLALVKQIVEKYGGTIEVESEegEGTVFTVRLPK 386
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
123-352 |
2.01e-21 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 95.49 E-value: 2.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 123 ALNHLAEQLQ---KQEKLRVTMTQDIAHELRTPLATLKShmQA---MLDQIWDPTP-----ARLRACYEETERLialVAD 191
Cdd:PRK10490 646 TLTASEEQARlasEREQLRNALLAALSHDLRTPLTVLFG--QAeilTLDLASEGSPharqaSEIRQQVLNTTRL---VNN 720
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 192 LEQLTVMDSPHFRLQRKPEDLSTLIQQSLGIVAAAFMEKGVRLDVMPHLsVRLHVDRDRFIQVLVNVLTNALKFTPEKGQ 271
Cdd:PRK10490 721 LLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPL-TLIHVDGPLFERVLINLLENAVKYAGAQAE 799
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 272 VKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSrnRKMGGAGIGLTIVKKLVEAHGGTVWIESDKGTTVYLR 351
Cdd:PRK10490 800 IGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKE--SAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFR 877
|
.
gi 517837428 352 F 352
Cdd:PRK10490 878 V 878
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
241-352 |
2.37e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 87.85 E-value: 2.37e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 241 SVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQdENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKsrnRKMGGA 320
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLS-ADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGS 79
|
90 100 110
....*....|....*....|....*....|....
gi 517837428 321 GIGLTIVKKLVEAHGGTVWIES--DKGTTVYLRF 352
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFLGNaqGGGLEAWVRL 113
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
51-353 |
3.21e-21 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 94.97 E-value: 3.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 51 GLAyHLEQALLQSMMWTLV--GAVLLSIMISLY--VAKRLSAPLVEMKNAAEQITRGKLTV----RTSIRGNDELADLG- 121
Cdd:PRK11466 318 GLA-HLEKASARGQYSLLLlgMVSLCALILILWrvVYRSVTRPLAEQTQALQRLLDGDIDSpfpeTAGVRELDTIGRLMd 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 122 ------KALNHLAEQLQKQEKLRVTMTQDI-------------------------AHELRTPLATLKSHMQAMLDQiwdP 170
Cdd:PRK11466 397 afrsnvHALNRHREQLAAQVKARTAELQELviehrqaraeaekasqaksaflaamSHEIRTPLYGILGTAQLLADN---P 473
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 171 TPAR----LRACYEETERLIALVADLEQLTVMD--SPHFRLQRKPEDLSTLIQQSLGIVAAAFMEKGVRL--DVMPHLSV 242
Cdd:PRK11466 474 ALNAqrddLRAITDSGESLLTILNDILDYSAIEagGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLatDIADDLPT 553
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 243 RLHVDRDRFIQVLVNVLTNALKFTpEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRnrkmGGAGI 322
Cdd:PRK11466 554 ALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGL 628
|
330 340 350
....*....|....*....|....*....|...
gi 517837428 323 GLTIVKKLVEAHGGTVWIES--DKGTTVYLRFP 353
Cdd:PRK11466 629 GLTISSRLAQAMGGELSATStpEVGSCFCLRLP 661
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
247-344 |
1.67e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 85.21 E-value: 1.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 247 DRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKmGGAGIGLTI 326
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYI 79
|
90
....*....|....*...
gi 517837428 327 VKKLVEAHGGTVWIESDK 344
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQ 97
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-353 |
2.46e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 84.69 E-value: 2.46e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 253 QVLVNVLTNALKFTPEK--GQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDkSRNrKMGGAGIGLTIVKKL 330
Cdd:cd16921 3 QVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH-SRE-EYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 517837428 331 VEAHGGTVWIES--DKGTTVYLRFP 353
Cdd:cd16921 81 IERHGGRIWLESepGEGTTFYFTLP 105
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-353 |
2.85e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 81.95 E-value: 2.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 254 VLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYrvDKSRNRKMGGA-GIGLTIVKKLVE 332
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGF--TGENGRNFQEStGMGLYLVKKLCD 86
|
90 100
....*....|....*....|...
gi 517837428 333 AHGGTVWIESD--KGTTVYLRFP 353
Cdd:cd16948 87 KLGHKIDVESEvgEGTTFTITFP 109
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
56-347 |
1.33e-18 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 87.21 E-value: 1.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 56 LEQALLQS----MMWTLVgaVLLSIMISLYVAKRLS----APLVEMKNAAEQITRGKLTVRtsIRGN--DELADLGKALN 125
Cdd:PRK11107 166 LKSVRLQQyreiFIAFLM--LLLGIGLALLFAFRLMrdvtGPIRNMVNTVDRIRRGQLDSR--VEGNmlGELDMLKNGIN 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 126 HLAEQL------------QKQEKLRVTMTQ--------DIA-------------------HELRTPL--------ATLK- 157
Cdd:PRK11107 242 AMAMSLsayheemqqnidQATSDLRETLEQmeiqnvelDLAkkraqeaarikseflanmsHELRTPLngvigftrQTLKt 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 158 ---SHMQAMLDQIwdptparlracyeetER----LIALVAD------LE--QLTVMDSPhFRLQRKPEDLSTLIQQSLgi 222
Cdd:PRK11107 322 pltPTQRDYLQTI---------------ERsannLLAIINDildfskLEagKLVLENIP-FSLRETLDEVVTLLAHSA-- 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 223 vaaafMEKGVRLDVMPHLSVRLHVDRD--RFIQVLVNVLTNALKFTpEKGQVKIQVQ-----DENDTVLIAIQDTGTGIA 295
Cdd:PRK11107 384 -----HEKGLELTLNIDPDVPDNVIGDplRLQQIITNLVGNAIKFT-ESGNIDILVElralsNTKVQLEVQIRDTGIGIS 457
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 517837428 296 PNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIES--DKGTT 347
Cdd:PRK11107 458 ERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSqpNRGST 511
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
128-353 |
2.68e-18 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 86.33 E-value: 2.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 128 AEQLQKQEKLRVTMTQD-----IAHELRTPLATLKSHMQaMLDQIWDPTPARLRA---CYEETERLIALVADLEQLTVMD 199
Cdd:PRK09959 697 ALEVERNKAINATVAKSqflatMSHEIRTPISSIMGFLE-LLSGSGLSKEQRVEAislAYATGQSLLGLIGEILDVDKIE 775
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 200 SPHFRLQRKPEDLSTLIQ---QSLGIVAAAfmeKGVRLD---VMP-HLSVRlhVDRDRFIQVLVNVLTNALKFTPEkGQV 272
Cdd:PRK09959 776 SGNYQLQPQWVDIPTLVQntcHSFGAIAAS---KSIALScssTFPdHYLVK--IDPQAFKQVLSNLLSNALKFTTE-GAV 849
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 273 KI-----QVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVdkSRNRKMGGAGIGLTIVKKLVEAHGGTVWIESDK--G 345
Cdd:PRK09959 850 KIttslgHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQT--SAGRQQTGSGLGLMICKELIKNMQGDLSLESHPgiG 927
|
....*...
gi 517837428 346 TTVYLRFP 353
Cdd:PRK09959 928 TTFTITIP 935
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-345 |
3.21e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 79.00 E-value: 3.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 253 QVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYrvdksRNRKMG-GAGIGLTIVKKLV 331
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF-----TTKPVGeGTGLGLSLSYRII 80
|
90
....*....|....
gi 517837428 332 EAHGGTVWIESDKG 345
Cdd:cd16943 81 QKHGGTIRVASVPG 94
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
60-354 |
1.25e-17 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 83.53 E-value: 1.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 60 LLQSMMWTLVGAVLLSIMISLYVAKRLSAPLVEMKNAAEQITRGKLtVRTSIRGNDELADLGKALNHLAEQLQKQEKlRV 139
Cdd:COG2972 155 LRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIE-EV 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 140 TMTQDIAHELRtpLATLKSHMQ-----------AMLDQIWDPtparlracyEETERLIALVADLeqltvmdsphFRLQ-R 207
Cdd:COG2972 233 YELELEKKEAE--LKALQAQINphflfntlnsiRWLAELEDP---------EEAEEMLEALSKL----------LRYSlS 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 208 KPEDLSTL------IQQSLGIvaaafmeKGVRLDvmPHLSVRLHVDRD--------RFIQVLV-NVLTNALKFTPEKGQV 272
Cdd:COG2972 292 KGDELVTLeeelelIKSYLEI-------QKLRFG--DRLEVEIEIDEElldllipkLILQPLVeNAIEHGIEPKEGGGTI 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 273 KIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRnrkmggaGIGLTIVK---KLVEAHGGTVWIES--DKGTT 347
Cdd:COG2972 363 RISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGR-------GIGLRNVRerlKLYYGEEYGLEIESepGEGTT 435
|
....*..
gi 517837428 348 VYLRFPK 354
Cdd:COG2972 436 VTIRIPL 442
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
71-354 |
1.63e-17 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 82.32 E-value: 1.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 71 AVLLSIMISLYVAKRLSAPLVEMKNAAEQITRGKLT---VRTSIrgnDELADLGKALNHLAEQLQ---KQEKLrvtMTQD 144
Cdd:PRK10755 70 MVSLTLLICFQAVRWITRPLAELQKELEARTADNLTpiaIHSST---LEIEAVTSALNQLVSRLTstlDQERL---FTAD 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 145 IAHELRTPLATLKSHMQAMLDQ-IWDPTP--ARLRACYEETERLIALvADLEQltVMDSPHFRLQRKPEDLSTLIQQSLG 221
Cdd:PRK10755 144 VAHELRTPLAGIRLHLELLEKQhHIDVAPliARLDQMMHTVEQLLQL-ARAGQ--SFSSGHYQTVKLLEDVILPSQDELS 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 222 IVAAAfmeKGVRLDVmPHLSVRLHVDRDR-FIQVLV-NVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDL 299
Cdd:PRK10755 221 EMLEQ---RQQTLLL-PESAADITVQGDAtLLRLLLrNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKC 296
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 517837428 300 PYVFERFYRVDksrnRKMGGAGIGLTIVKKLVEAHGGTVWIESDK---GTTVYLRFPK 354
Cdd:PRK10755 297 GELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQFFLQNRQersGTRAWVWLPK 350
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
128-345 |
6.77e-17 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 81.91 E-value: 6.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 128 AEQLQKQEKLRVTMTQDIAHELRTPLATLK--SHMqaMLD-QIWDPTPARLRACYEETERLIALVADLEQLTVMDSPHFR 204
Cdd:PRK11091 273 QDALEKASRDKTTFISTISHELRTPLNGIVglSRI--LLDtELTAEQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKLQ 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 205 LQRKP-------EDLSTLIqqslGIVAAafmEKGVRLDVMPHLSVRLHVDRD--RFIQVLVNVLTNALKFTpEKGQVKIQ 275
Cdd:PRK11091 351 LDNQPidftdflADLENLS----GLQAE---QKGLRFDLEPLLPLPHKVITDgtRLRQILWNLISNAVKFT-QQGGVTVR 422
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517837428 276 VQ-DENDTVLIAIQDTGTGIAPNDLPYVFERFYRV-DKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIESDKG 345
Cdd:PRK11091 423 VRyEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEG 494
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
237-342 |
1.12e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 75.24 E-value: 1.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 237 MPHLSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRK 316
Cdd:cd16947 7 IPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSA 86
|
90 100
....*....|....*....|....*.
gi 517837428 317 MGGAGIGLTIVKKLVEAHGGTVWIES 342
Cdd:cd16947 87 KQGNGLGLTITKRLAESMGGSIYVNS 112
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-345 |
2.06e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 73.97 E-value: 2.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 253 QVLVNVLTNALK----FTPEKGQVKIQV-QDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSrnrkmgGAGIGLTIV 327
Cdd:cd16920 3 QVLINLVRNGIEamseGGCERRELTIRTsPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSIC 76
|
90
....*....|....*...
gi 517837428 328 KKLVEAHGGTVWIESDKG 345
Cdd:cd16920 77 RSIIEAHGGRLSVESPAG 94
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-338 |
3.09e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 73.25 E-value: 3.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 253 QVLVNVLTNALKFTpeKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNrkMGGAGIGLTIVKKLVE 332
Cdd:cd16950 3 RVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISD 78
|
....*.
gi 517837428 333 AHGGTV 338
Cdd:cd16950 79 AHGGSL 84
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-341 |
6.13e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 72.85 E-value: 6.13e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 254 VLVNVLTNALKFTpeKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEA 333
Cdd:cd16939 4 ALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALW 81
|
....*...
gi 517837428 334 HGGTVWIE 341
Cdd:cd16939 82 HGGHVECD 89
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
46-353 |
3.22e-15 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 76.71 E-value: 3.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 46 DHSLPGLAYHLEQALLQSMMWTLvgAVLLSIMISLYV-AKRLSAPLVEMKNAAEQI--TRGKLTVR-TSIRGNDELADLG 121
Cdd:TIGR03785 391 EQTTNGIRTLRNSALEKLFNVIL--AIMSIGTLALFGfASWISWRIRRLSDDAEAAidSQGRISGAiPASRSRDEIGDLS 468
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 122 KALNHLAEQLQKQEKLRVTMTQDIAHELRTPLATLKSHMQ--AMLDQIWDPTPARLRAcYEETERLIALVADLEQLTVMD 199
Cdd:TIGR03785 469 RSFAQMVARLRQYTHYLENMSSRLSHELRTPVAVVRSSLEnlELQALEQEKQKYLERA-REGTERLSMILNNMSEATRLE 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 200 SPHFRLQRKPEDLSTLIQqslGIVAAAFM-EKGVRLDV-MPHLSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQ 277
Cdd:TIGR03785 548 QAIQSAEVEDFDLSEVLS---GCMQGYQMtYPPQRFELnIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLS 624
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517837428 278 DENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIE---SDKGTTVYLRFP 353
Cdd:TIGR03785 625 QNKSHALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAEnrqQNDGVVFRISLP 703
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
116-342 |
7.83e-15 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 75.44 E-value: 7.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 116 ELADLGKALNHL-AEQLQKQEKLRVTMTqDIAHELRTPLATLKSHMQAMLD----QIWDPTPARLracyEETERLIALVA 190
Cdd:PRK10815 244 ELTSLVRNLNRLlKNERERYTKYRTTLT-DLTHSLKTPLAVLQSTLRSLRSgkqmSVEQAEPIML----EQISRISQQIG 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 191 DLEQLTVMDSPHFRLQRKPEDLSTLIQQSLGIVAAAFMEKGV--RLDVMPHLSvrLHVDRDRFIQVLVNVLTNALKFTPE 268
Cdd:PRK10815 319 YYLHRASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVniTLDISPEIT--FVGEKNDFMEVMGNVLDNACKYCLE 396
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517837428 269 KgqVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNrkmgGAGIGLTIVKKLVEAHGGTVWIES 342
Cdd:PRK10815 397 F--VEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGD 464
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
116-338 |
8.05e-15 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 75.07 E-value: 8.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 116 ELADLGKALNHLAEQLQKQEKLRVTMTQDIAHELRTPLATLKshMQAMLDQIWDPTPA-RLRA---CYEETERLIALVAD 191
Cdd:PRK10337 215 EVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALK--VQTEVAQLSDDDPQaRKKAllqLHAGIDRATRLVDQ 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 192 LEQLTVMDSPHFRLQRKPEDLSTLIQQSLgivaaafmekgvrLDVMPH-----LSVRLHVDRDRFIQ--------VLV-N 257
Cdd:PRK10337 293 LLTLSRLDSLDNLQDVAEIPLEDLLQSAV-------------MDIYHTaqqagIDVRLTLNAHPVIRtgqplllsLLVrN 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 258 VLTNALKFTPEKGQVKIQVQDENDTVLiaiqDTGTGIAPNDLPYVFERFYR---VDKSrnrkmgGAGIGLTIVKKLVEAH 334
Cdd:PRK10337 360 LLDNAIRYSPQGSVVDVTLNARNFTVR----DNGPGVTPEALARIGERFYRppgQEAT------GSGLGLSIVRRIAKLH 429
|
....
gi 517837428 335 GGTV 338
Cdd:PRK10337 430 GMNV 433
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
210-344 |
2.23e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 69.20 E-value: 2.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 210 EDLSTLIQqSLGIVaaaFMEKGVRL--DVMPhlSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENdtVLIAI 287
Cdd:cd16954 1 PLLDSLCS-ALNKV---YQRKGVSIslDISP--ELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGG--LHLIV 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 517837428 288 QDTGTGIAPNDLPYVFERFYRVDKSRNrkmgGAGIGLTIVKKLVEAHGGTVWIESDK 344
Cdd:cd16954 73 DDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSP 125
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-338 |
2.91e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 68.26 E-value: 2.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 253 QVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMgGAGIGLTIVKKLVE 332
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQEVAQ 85
|
....*.
gi 517837428 333 AHGGTV 338
Cdd:cd16945 86 LHGGRI 91
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
253-338 |
5.40e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 67.60 E-value: 5.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 253 QVLVNVLTNALKFTP-EKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYrVDKSRNRKMG-GAGIGLTIVKKL 330
Cdd:cd16953 3 QVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISRQI 81
|
....*...
gi 517837428 331 VEAHGGTV 338
Cdd:cd16953 82 IEAHGGIS 89
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
130-353 |
1.70e-13 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 71.24 E-value: 1.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 130 QLQKQEKLRvTMTQDIAHELRTPLATLKSH---MQAMLDQIwDPTPARLRACYEETERLIALVADLEQLTVMDSPHFRLQ 206
Cdd:PRK13557 156 QAQKMEALG-QLTGGIAHDFNNLLQVMSGYldvIQAALSHP-DADRGRMARSVENIRAAAERAATLTQQLLAFARKQRLE 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 207 RKPEDLSTLIQqSLGIVAAAFMEKGVRLDVmpHLSVRL---HVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQ----DE 279
Cdd:PRK13557 234 GRVLNLNGLVS-GMGELAERTLGDAVTIET--DLAPDLwncRIDPTQAEVALLNVLINARDAMPEGGRVTIRTRnveiED 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 280 NDT-----------VLIAIQDTGTGIAPNDLPYVFERFYrVDKSRNRkmgGAGIGLTIVKKLVEAHGGTVWIESD--KGT 346
Cdd:PRK13557 311 EDLamyhglppgryVSIAVTDTGSGMPPEILARVMDPFF-TTKEEGK---GTGLGLSMVYGFAKQSGGAVRIYSEvgEGT 386
|
....*..
gi 517837428 347 TVYLRFP 353
Cdd:PRK13557 387 TVRLYFP 393
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
251-353 |
4.53e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 64.62 E-value: 4.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 251 FIQVLVNVLTNALKFT----PEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRkmggaGIGLTI 326
Cdd:cd16915 1 LITIVGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLAL 75
|
90 100
....*....|....*....|....*....
gi 517837428 327 VKKLVEAHGGTVWIESDK--GTTVYLRFP 353
Cdd:cd16915 76 VRQSVERLGGSITVESEPggGTTFSIRIP 104
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
238-345 |
3.28e-12 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 67.69 E-value: 3.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 238 PHLSVRLHVDRDRFIQVLVNVLTNALKFTpEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKM 317
Cdd:PRK10841 550 PDVPVALNGDPMRLQQVISNLLSNAIKFT-DTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNF 628
|
90 100
....*....|....*....|....*...
gi 517837428 318 GGAGIGLTIVKKLVEAHGGTVWIESDKG 345
Cdd:PRK10841 629 QGTGLGLAICEKLINMMDGDISVDSEPG 656
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
127-353 |
3.92e-12 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 67.40 E-value: 3.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 127 LAEQLQKQEKLRV--TMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPAR--LRACYEETERLIALVadlEQLTVMDSPH 202
Cdd:PRK13837 437 LERRLEHARRLEAvgTLASGIAHNFNNILGAILGYAEMALNKLARHSRAAryIDEIISAGARARLII---DQILAFGRKG 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 203 fRLQRKPEDLSTLIQQSLGIVAAAfMEKGVRLDVMPHlSVRLHV--DRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDEN 280
Cdd:PRK13837 514 -ERNTKPFDLSELVTEIAPLLRVS-LPPGVELDFDQD-QEPAVVegNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAK 590
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 281 ---------------DTVLIAIQDTGTGIAPNDLPYVFERFYrvdKSRNrkmGGAGIGLTIVKKLVEAHGG--TVWIESD 343
Cdd:PRK13837 591 lrapkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGyiDVQSTVG 664
|
250
....*....|
gi 517837428 344 KGTTVYLRFP 353
Cdd:PRK13837 665 RGTRFDVYLP 674
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
247-353 |
4.98e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 59.09 E-value: 4.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 247 DRDRFIQVLVNVLTNALKFTPE----KGQVKIQVQDENDT-VLIAIQDTGTGIAPNDLPYVFERfYRVDKSRnrkmgGAG 321
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGrpsdVGEVRIRVEADQDGrIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 517837428 322 IGLTIVKKLVEAHGGTVWIES--DKGTTVYLRFP 353
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNreAGGACIRIILP 108
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
252-338 |
7.07e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 58.62 E-value: 7.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 252 IQVLVNVLTNALKFTP--EKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYrvdksRNRKMG-GAGIGLTIVK 328
Cdd:cd16976 2 QQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSISY 76
|
90
....*....|
gi 517837428 329 KLVEAHGGTV 338
Cdd:cd16976 77 GIVEEHGGRL 86
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
251-353 |
1.90e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 57.77 E-value: 1.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 251 FIQVLVNVLTNALKFTPEKGQVKIQVQDE---------------NDTVLIAIQDTGTGIAPNDLPYVFERFYrvdksRNR 315
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSNQrvdadyalnyrdlipGNYVCLEVSDTGSGMPAEVLRRAFEPFF-----TTK 75
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 517837428 316 KMG-GAGIGLTIVKKLVEAHGGTVWIES--DKGTTVYLRFP 353
Cdd:cd16919 76 EVGkGTGLGLSMVYGFVKQSGGHLRIYSepGVGTTVRIYLP 116
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
87-131 |
2.59e-10 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 55.14 E-value: 2.59e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 517837428 87 SAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQL 131
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| ActS_PrrB_HisK |
NF033792 |
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ... |
146-338 |
3.59e-10 |
|
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.
Pssm-ID: 468186 [Multi-domain] Cd Length: 423 Bit Score: 60.99 E-value: 3.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 146 AHELRTPLATLKSHMQAMLDQIWDPTPAR-----LRacyEETERLIALVADLEQLTVMDSPHFRlqRKPedLSTLIQQsl 220
Cdd:NF033792 210 AHELGTPLATIALVAKELERELPDDPPLRedaelLR---SQAERCRDILRRLTSLGEEGDAHLD--RLP--LSALIEE-- 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 221 giVAAAFMEKGVRLDVMPHLSVRLHVDRDR---FIQVLVNVLTNALKFTpeKGQVKIQVQDENDTVLIAIQDTGTGIAPN 297
Cdd:NF033792 281 --AAAPHRGFGKEIEVVVAGDPGEEPVIRRnpeILYGLGNLIENAVDFA--RSTVTVTASWDAESVTITIEDDGPGFPPD 356
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 517837428 298 DL-----PYVFERfyRVDKSRNRKmGGAGIGLTIVKKLVEAHGGTV 338
Cdd:NF033792 357 VLsrigePYVTTR--RGEERRPGG-GGLGLGLFIAKTLLERSGATV 399
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
52-151 |
4.30e-10 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 60.80 E-value: 4.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 52 LAYHLEQALLQSMMWTLVGAVLLSIMISLYVAKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQL 131
Cdd:COG0840 172 LALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENL 251
|
90 100
....*....|....*....|
gi 517837428 132 QKQeklrVTMTQDIAHELRT 151
Cdd:COG0840 252 REL----VGQVRESAEQVAS 267
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
252-353 |
5.29e-10 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 60.70 E-value: 5.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 252 IQVLVNVLTNALKFTP--EKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVdKSRNRkmggaGIGLTIVKK 329
Cdd:PRK11086 435 ITILGNLIENALEAVGgeEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYST-KGSNR-----GVGLYLVKQ 508
|
90 100
....*....|....*....|....*.
gi 517837428 330 LVEAHGGTVWIESDKG--TTVYLRFP 353
Cdd:PRK11086 509 SVENLGGSIAVESEPGvgTQFFVQIP 534
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
16-326 |
7.36e-10 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 60.51 E-value: 7.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 16 VASGILLIAGISFMAGTHYHFRLYQDQYGMDHSLPGLAYHLEQALLQSMMWTLVGAVLLSIMISLYVAKRLSAPLVEMKN 95
Cdd:COG2770 166 LALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAE 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 96 AAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQLQ--------KQEKLRVTMTQDIAHELRTPLATLKSHMQAMLDQI 167
Cdd:COG2770 246 AARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLResieeaeeEEELAEAELARLLEALLELLLALLLLLLALLLLAA 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 168 WDPTPARLRACYEETERLIALVADLEQLTVMDSPHFRLQRKPEDLSTLIQQSLGIVAAAFMEKGVRLDVMPHLSVRLHVD 247
Cdd:COG2770 326 AALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLL 405
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517837428 248 RDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTI 326
Cdd:COG2770 406 ELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAAL 484
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
211-353 |
8.02e-10 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 59.92 E-value: 8.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 211 DLSTLIQQSLGIVAAAFMEKGVRLdvmpHLSV-RLHVDRDRFIQV--LVN-VLTNALKF---TPEKGQVKIQVQDENDTV 283
Cdd:COG3920 360 DLRDYLRELLEPLRDSYGGRGIRI----ELDGpDVELPADAAVPLglILNeLVTNALKHaflSGEGGRIRVSWRREDGRL 435
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 284 LIAIQDTGTGIAPNdlpyvferfyrVDKSRnrkmgGAGIGLTIVKKLVEAHGGTVWIESDKGTTVYLRFP 353
Cdd:COG3920 436 RLTVSDNGVGLPED-----------VDPPA-----RKGLGLRLIRALVRQLGGTLELDRPEGTRVRITFP 489
|
|
| HAMP |
pfam00672 |
HAMP domain; |
82-133 |
1.72e-09 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 53.01 E-value: 1.72e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 517837428 82 VAKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQLQK 133
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
252-349 |
2.38e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 54.33 E-value: 2.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 252 IQVLVNVLTNALKFTPEKG-----------QVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFYrvdksrNRKMGGA 320
Cdd:cd16918 2 IQVFLNLVRNAAQALAGSGgeiilrtrtqrQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMV------SGRENGT 75
|
90 100
....*....|....*....|....*....
gi 517837428 321 GIGLTIVKKLVEAHGGTVWIESDKGTTVY 349
Cdd:cd16918 76 GLGLAIAQNIVSQHGGVIECDSQPGHTVF 104
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
84-135 |
4.31e-09 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 51.87 E-value: 4.31e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 517837428 84 KRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLAEQLQKQE 135
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETI 52
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
49-352 |
7.22e-09 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 56.82 E-value: 7.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 49 LPGLAYHLEQALLQSMMWTLVGAVLLSIMISLYVAKRLSAPLVEMKNAAEQITRGKLTVRTSIRGNDELADLGKALNHLA 128
Cdd:COG3850 105 LLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMA 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 129 EQLQK-QEKLRVTMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPARLRACYEETERLIALVADLEQLTVMDSPHFRLQR 207
Cdd:COG3850 185 DELQElYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLE 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 208 KPEDLSTLIQQSL------GIVAAAFMEKGVRLDVMPHLSVRLHVDRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDEND 281
Cdd:COG3850 265 LLLALLLLLLASAllllelELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELA 344
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517837428 282 TVLIAIQDTGTGIAPNDLPYVFERFYRVDKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIESDKGTTVYLRF 352
Cdd:COG3850 345 SILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGG 415
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
135-196 |
4.34e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 49.52 E-value: 4.34e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517837428 135 EKLRVTMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPAR--LRACYEETERLIALVADLEQLT 196
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQReyLERIREEAERLLRLINDLLDLS 64
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
202-353 |
4.74e-08 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 51.07 E-value: 4.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 202 HFRLQRKPEDLSTLIQqslgIVAAAFMEKGVRLDvmphlsvrlhvDRDRFIQVLVNVLTNALKFT---PEKGQVKIQVQD 278
Cdd:COG2172 1 SLSLPADLEDLGLARR----AVRALLRELGLDED-----------DADDLVLAVSEAVTNAVRHAyggDPDGPVEVELEL 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517837428 279 ENDTVLIAIQDTGTGIAPNDLPyvferfyrvdkSRNRKMGGAGIGLTIVKKLVEAhggtVWIESDK-GTTVYLRFP 353
Cdd:COG2172 66 DPDGLEIEVRDEGPGFDPEDLP-----------DPYSTLAEGGRGLFLIRRLMDE----VEYESDPgGTTVRLVKR 126
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
138-201 |
1.46e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 47.95 E-value: 1.46e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517837428 138 RVTMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPAR-LRACYEETERLIALVADLEQLTVMDSP 201
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREyLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
105-353 |
2.60e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 51.16 E-value: 2.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 105 LTVRTSIRGNDELADLGKALNHLAEQLQKQEKLRvtmtqdIAHEL------RtpLATLKSHMQAMLDQIwDPTPARLRAC 178
Cdd:COG4585 23 ALVLLRARRAERAAELERELAARAEEAREEERRR------IARELhdgvgqS--LSAIKLQLEAARRLL-DADPEAAREE 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 179 YEETERLI-ALVADLEQL-TVMDSPHFRLQRKPEDLSTLIQQslgIVAAAFMEkgVRLDVMPHL-----SVRLHVDRdrf 251
Cdd:COG4585 94 LEEIRELArEALAELRRLvRGLRPPALDDLGLAAALEELAER---LLRAAGIR--VELDVDGDPdrlppEVELALYR--- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 252 iqVLVNVLTNALKFTPEKgQVKIQVQDENDTVLIAIQDTGTGIAPNDLPyvferfyrvdksrnrkmgGAGIGLTIVKKLV 331
Cdd:COG4585 166 --IVQEALTNALKHAGAT-RVTVTLEVDDGELTLTVRDDGVGFDPEAAP------------------GGGLGLRGMRERA 224
|
250 260
....*....|....*....|....
gi 517837428 332 EAHGGTVWIES--DKGTTVYLRFP 353
Cdd:COG4585 225 EALGGTLTIGSapGGGTRVRATLP 248
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
138-201 |
9.03e-07 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 45.67 E-value: 9.03e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517837428 138 RVTMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPAR-LRACYEETERLIALVADLEQLTVMDSP 201
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREyLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
228-346 |
1.31e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 47.19 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 228 MEKGVRLDVMPHLSVRLHVDRDRFIQVLVNVLTNAL----KFTPEKGQVKIQVQDENDTVLIAIQDTgtgiAPNDLPYVF 303
Cdd:cd16935 14 REKGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAIeacaKIDKENRFIHLKIRQKKGFLIISIENS----YEGELKKKN 89
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 517837428 304 ERFYRVDKSRNRkmggaGIGLTIVKKLVEAHGGTVWIESDKGT 346
Cdd:cd16935 90 GLFLSTKKDKNH-----GIGLKSIREIVKKYNGNLSIEYENGI 127
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
229-354 |
1.39e-06 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 49.83 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 229 EKGVRLDVMPhlSVRLH-----VDRDRFIQVLVNVLTNALKF---TPE-KGQVKIQVQDENDTVLIAIQDTGTGIAPNDL 299
Cdd:PRK15053 408 ELGLKMVIVP--GSQLSqlppgLDSTEFAAIVGNLLDNAFEAslrSDEgNKIVELFLSDEGDDVVIEVADQGCGVPESLR 485
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 517837428 300 PYVFERFYrvdKSRNRKMGGAGIGLTIVKKLVEAHGGTVWIESDK--GTTVYLRFPK 354
Cdd:PRK15053 486 DKIFEQGV---STRADEPGEHGIGLYLIASYVTRCGGVITLEDNDpcGTLFSIFIPK 539
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
259-353 |
1.67e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 45.62 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 259 LTNALKFTPEkGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPyvferfyrvdksrnrkmGGAGIGLTIVKKLVEAHGGTV 338
Cdd:cd16917 9 LTNALKHAGA-SRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*..
gi 517837428 339 WIES--DKGTTVYLRFP 353
Cdd:cd16917 71 TIGSrpGGGTRVTARLP 87
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
129-350 |
2.16e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 48.92 E-value: 2.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 129 EQLQ--KQEKLRVtMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPARL-RACYEETERLIALVADLEqltvmdSPHFRL 205
Cdd:PRK11073 120 EQLQhaQQVAARD-LVRGLAHEIKNPLGGLRGAAQLLSKALPDPALTEYtKVIIEQADRLRNLVDRLL------GPQRPG 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 206 QRKPEDLSTLIQQSLGIVAaafMEKG--VRL--DVMPHLSVRLHvDRDRFIQVLVNVLTNALKFTPEKG----------- 270
Cdd:PRK11073 193 THVTESIHKVAERVVQLVS---LELPdnVRLirDYDPSLPELAH-DPDQIEQVLLNIVRNALQALGPEGgtitlrtrtaf 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 271 QVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFerfYRVDKSRNrkmGGAGIGLTIVKKLVEAHGGTVWIESDKGTT--- 347
Cdd:PRK11073 269 QLTLHGERYRLAARIDIEDNGPGIPPHLQDTLF---YPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGHTefs 342
|
...
gi 517837428 348 VYL 350
Cdd:PRK11073 343 VYL 345
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
126-329 |
3.10e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 49.16 E-value: 3.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 126 HLAEQL-QKQEKLRVTMTQDIAHELRTPLATLKSHMQAMLDQIWDPTPAR-LRACYEETERLIALVADLEQLTVMDSPHF 203
Cdd:PRK10618 437 QQAQREyEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPeLDQLAEQSDVLVRLVDNIQLLNMLETQDW 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 204 RLQRKPEDLSTLIQQSLGIVAAAFMEKGVRLDVMPHLSVR--LHVDRDRFIQVLVNVLTNALKFTPeKGQVKIQV-QDEN 280
Cdd:PRK10618 517 KPEQELFSLQDLIDEVLPEVLPAIKRKGLQLLIHNHLKAEqlRIGDRDALRKILLLLLNYAITTTA-YGKITLEVdQDES 595
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517837428 281 --DTVLIAIQDTGTGIAPNDL-----PY----VFERFYRVD-------KSRNRKMGGAgigLTIVKK 329
Cdd:PRK10618 596 spDRLTIRILDTGAGVSIKELdnlhfPFlnqtQGDRYGKASgltfflcNQLCRKLGGH---LTIKSR 659
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
55-133 |
5.16e-06 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 48.13 E-value: 5.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 55 HLEQ-ALLQSMMwtLVGAVLLSIMISLYVAKRLSAP---LVEMKNAaeqITRGKLTVRTSIRGNDELADLGKALNHLAEQ 130
Cdd:PRK10600 119 RIETvVLVHRVF--AVFMALLLVFTIIWLRRRLLQPwrqLLSMANA---VSHRDFTQRANISGRDEMAMLGTALNNMSAE 193
|
...
gi 517837428 131 LQK 133
Cdd:PRK10600 194 LAE 196
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
251-353 |
9.66e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 43.96 E-value: 9.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 251 FIQVLV-NVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPndlpyvferfyrVDKSRNRKMGGAGIGLTIV-K 328
Cdd:cd16956 5 TLQPIVeNAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDP------------DTLARILIRSSNGLGLNLVdK 72
|
90 100
....*....|....*....|....*....
gi 517837428 329 KLVEA----HGGTVWIESDKGTTVYLRFP 353
Cdd:cd16956 73 RLRQAfgndYGLDIECAPGEGTRITIRLP 101
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
216-353 |
1.56e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 43.95 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 216 IQQSLGIVAAAFMEKGVRLDVMPHLsVRLHVDRDRFIQVLVN-VLTNALK--FTP-EKGQVKIQVQDENDTVLIAIQDTG 291
Cdd:cd16951 5 INRIASAINAIHAVGDIRINITGDT-GPVSSEVATAIGLVVNeLLQNALKhaFSDrEGGTITIRSVVDGDYLRITVIDDG 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517837428 292 TGIApndlpyvfERFYRVDKSRnrkmggagIGLTIVKKLVEAHGGT--VWIESDKGTTVYLRFP 353
Cdd:cd16951 84 VGLP--------QDEDWPNKGS--------LGLQIVRSLVEGELKAflEVQSAENGTRVNIDIP 131
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
252-353 |
7.45e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 41.28 E-value: 7.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 252 IQVLV-NVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPyvferfyrvdKSRNRKMGGAGIGLTIVKKL 330
Cdd:cd16924 6 LQPLVeNAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLN----------ILGKKPKEGNGIGLYNVHQR 75
|
90 100
....*....|....*....|....*...
gi 517837428 331 V-----EAHGGTVWIESDKGTTVYLRFP 353
Cdd:cd16924 76 LillfgEDYGIHIASEPDKGTRITFTIP 103
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
267-353 |
1.46e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 42.18 E-value: 1.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 267 PEKGQVKIQVQDENDTVLIAIQDTGTGIAPND-LPYVFERFYRVDKSRNR----------------------KMGGAGIG 323
Cdd:cd16916 67 PPEGTITLRAEHQGNQVVIEVSDDGRGIDREKiREKAIERGLITADEAATlsddevlnlifapgfstaeqvtDVSGRGVG 146
|
90 100 110
....*....|....*....|....*....|..
gi 517837428 324 LTIVKKLVEAHGGTVWIES--DKGTTVYLRFP 353
Cdd:cd16916 147 MDVVKRSIESLGGTIEVESepGQGTTFTIRLP 178
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
127-353 |
1.73e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 40.43 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 127 LAEQLQKQEKLRVTMTQ------DIAHELRTPLATLKSHMQAMLDQIWDPtpARLRACYEETERLIALVADLEQLTVMDS 200
Cdd:PRK13560 588 ISERKHAEEKIKAALTEkevllkEIHHRVKNNLQIISSLLDLQAEKLHDE--EAKCAFAESQDRICAMALAHEKLYQSED 665
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 201 PHFRlqrkpeDLSTLIQQSLGIVAAAFMEKGVRLDVMPHL-SVRLHVDRDRFIQVLVN-VLTNALKFT-PEK--GQVKIQ 275
Cdd:PRK13560 666 LADI------DFLDYIESLTAHLKNSFAIDFGRIDCKIDAdDGCLDIDKAIPCGLIISeLLSNALKHAfPDGaaGNIKVE 739
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517837428 276 VQDEND-TVLIAIQDTGTGiapndLPYVFErfYRVDKSrnrkmggagIGLTIVKKLVEAHGGTVWIESDKGTTVYLRFP 353
Cdd:PRK13560 740 IREQGDgMVNLCVADDGIG-----LPAGFD--FRAAET---------LGLQLVCALVKQLDGEIALDSRGGARFNIRFP 802
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
247-338 |
2.31e-03 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 37.25 E-value: 2.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 247 DRDRFIQVLVNVLTNALKFTP-EKGQVKIQVQ------DENDTVL---IAIQDTGTGIAPNDLPYVFErfyrvdksRNRK 316
Cdd:cd16932 3 DQIRLQQVLADFLLNAVRFTPsPGGWVEIKVSptkkqiGDGVHVIhleFRITHPGQGLPEELVQEMFE--------ENQW 74
|
90 100
....*....|....*....|..
gi 517837428 317 MGGAGIGLTIVKKLVEAHGGTV 338
Cdd:cd16932 75 TTQEGLGLSISRKLVKLMNGDV 96
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
267-353 |
2.92e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 39.39 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 267 PEKGQVKIQVQDENDTVLIAIQDTGTGIapnDLpyvfERFYR-------VDKSRNRKMG--------------------- 318
Cdd:COG0643 306 PETGTITLSAYHEGGRVVIEVSDDGRGL---DL----EKIRAkaiekglITAEEAAALSdeellelifapgfstaeevtd 378
|
90 100 110
....*....|....*....|....*....|....*....
gi 517837428 319 --GAGIGLTIVKKLVEAHGGTVWIES--DKGTTVYLRFP 353
Cdd:COG0643 379 lsGRGVGMDVVKTNIEALGGTIEIESepGKGTTFTLRLP 417
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
247-345 |
3.37e-03 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 37.44 E-value: 3.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 247 DRDRFIQVLVNVLTNALKFTPEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERF-YRVDKSR------------ 313
Cdd:cd16938 8 DERRVFQVLLHMLGNLLKMRNGGGNITFRVFLEGGSEDRSDRDWGPWRPSMSDESVEIRFeVEINDSGspsiesasmrns 87
|
90 100 110
....*....|....*....|....*....|....*..
gi 517837428 314 -NRKMG----GAGIGLTIVKKLVEAHGGTVWIESDKG 345
Cdd:cd16938 88 lNRRYNlselGEHLSFSICKQLVQLMGGNIWIVPGSG 124
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
268-351 |
3.38e-03 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 37.52 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 268 EKGQVKIQVQDENDTVLIAIQDTGTGIApnDLPYVFERFYRVDKSRNRkmggAGIGLTIVKKLVEAHggTVWIESDKGTT 347
Cdd:cd16942 59 PNGIVSISVIIEDGVVHLTVRDEGVGIP--DIEEARQPLFTTKPELER----SGMGFTIMENFMDEV--IVESEVNKGTT 130
|
....
gi 517837428 348 VYLR 351
Cdd:cd16942 131 VYLK 134
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
258-353 |
3.57e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 37.71 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 258 VLTNALKFTPEKGQ--------VKIQVQDENDTVLIAIQDTGTGIAPNDLPYVFERFY-------------RVDKSRNRK 316
Cdd:cd16929 51 LLKNAMRATVESHGddsddlppIKVTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYstapqpslddfsdLISGTQPSP 130
|
90 100 110
....*....|....*....|....*....|....*....
gi 517837428 317 MGGAGIGLTIVKKLVEAHGGTVWIESDKG--TTVYLRFP 353
Cdd:cd16929 131 LAGFGYGLPMSRLYAEYFGGDLDLQSMEGygTDVYIYLK 169
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
259-354 |
3.82e-03 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 39.19 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 259 LTNALKFTpEKGQVKIQVQDENDTVLIAIQDTGTGIAPNDLPyvferfyrvdksrnrkmggAGIGLTIVKKLVEAHGGTV 338
Cdd:PRK11644 419 LNNIVKHA-DASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQ-------------------QGFGLRGMRERVTALGGTL 478
|
90
....*....|....*.
gi 517837428 339 WIESDKGTTVYLRFPK 354
Cdd:PRK11644 479 TISCTHGTRLSVSLPQ 494
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
252-348 |
8.92e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 35.51 E-value: 8.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517837428 252 IQVLV-NVLTNALKFTPEKGQVKIQVQDEND-TVLIAIQDTGTGIAPNDLpyvferfyrvDKSRNRKMGGAGIGLTIVK- 328
Cdd:cd16955 6 IQPLVeNAIVHGIQEKKGKGVVKISVKKQLKnRLHIAVEDNGIGISPKVI----------ERVEQDEMPGNKIGLLNVHq 75
|
90 100
....*....|....*....|..
gi 517837428 329 --KLVEAHGGTVWIESDKGTTV 348
Cdd:cd16955 76 rlKLGYGEGLHIRSRPDPGTLI 97
|
|
| |
