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Conserved domains on  [gi|517879254|ref|WP_019049462|]
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lysophospholipid acyltransferase family protein [Nocardia asteroides]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10168420)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0006644|GO:0008654
PubMed:  18718904|18931347|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 103-327 8.63e-39

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


:

Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 136.65  E-value: 8.63e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 103 LSDIWFRVETTGIENIPATGGALIVANHaGTVPLDGLMLQLAIHDKHPShRALRLLAADLIFELPLLGALARKAGHTLAC 182
Cdd:cd07987    1 HRKYFRVYEVRGLENIPDEGPALLVHPH-GGLPIDGALLAAAFLLLFPG-RLPRALADHFLFPLPGLRDLLRRLGAVPGS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 183 HPDAERLLRSGQIAGVFPEGFKGVGKNYADRYKLQRFGRGGFVSAAVRTGVPIIPCSIVGSEEIYPKLAD-----IKPLA 257
Cdd:cd07987   79 RENCVRLLREGELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDpdgpvGKRLF 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 258 RLLGLPYfpvtptfphlgplgavplPSKWYIEFGEPIATTAFEPEDADDPmTMFEVTDQVRETIQQTLYK 327
Cdd:cd07987  159 RLLPLPR------------------RLPLYPVFGEPIVVPRPPIPDPPDE-DVEELHQKYIAALRELIEK 209
 
Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 103-327 8.63e-39

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 136.65  E-value: 8.63e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 103 LSDIWFRVETTGIENIPATGGALIVANHaGTVPLDGLMLQLAIHDKHPShRALRLLAADLIFELPLLGALARKAGHTLAC 182
Cdd:cd07987    1 HRKYFRVYEVRGLENIPDEGPALLVHPH-GGLPIDGALLAAAFLLLFPG-RLPRALADHFLFPLPGLRDLLRRLGAVPGS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 183 HPDAERLLRSGQIAGVFPEGFKGVGKNYADRYKLQRFGRGGFVSAAVRTGVPIIPCSIVGSEEIYPKLAD-----IKPLA 257
Cdd:cd07987   79 RENCVRLLREGELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDpdgpvGKRLF 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 258 RLLGLPYfpvtptfphlgplgavplPSKWYIEFGEPIATTAFEPEDADDPmTMFEVTDQVRETIQQTLYK 327
Cdd:cd07987  159 RLLPLPR------------------RLPLYPVFGEPIVVPRPPIPDPPDE-DVEELHQKYIAALRELIEK 209
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 108-332 1.66e-26

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 104.32  E-value: 1.66e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 108 FRVETTGIENIPATGGALIVANHAGTvpLDGLMLQLAIhdkhpsHRALRLLAADLIFELPLLGALARKAGH--------- 178
Cdd:COG0204   29 VRVRVEGLENLPADGPVLIVANHQSW--LDILLLLAAL------PRPVRFVAKKELFKIPLLGWLLRALGAipvdrskrr 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 179 ----TLAchpDAERLLRSGQIAGVFPEGfkgvgkNYADRYKLQRFGRGGFVsAAVRTGVPIIPCSIVGSEEIYPKladik 254
Cdd:COG0204  101 aalrALR---QAVEALKAGESLVIFPEG------TRSPDGRLLPFKTGAAR-LALEAGVPIVPVAIDGTERALPK----- 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517879254 255 plarllglpyfpvtptfphlgplGAVPLPSKWYIEFGEPIATTAFEPEDADdpmtmfEVTDQVRETIQQTLYKLLAKR 332
Cdd:COG0204  166 -----------------------GFLPRPGKVTVRIGPPIDPSDLEGEDRR------ELAERLRAAIEALLAELRAEA 214
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 109-241 1.42e-21

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 88.49  E-value: 1.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254  109 RVETTGIENIPATGGALIVANHAGtvPLDGLMLQLAIHDkhpSHRALRLLAADLIFELPLLGALARKAGHTLAC------ 182
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQS--YLDVLLLSLALYK---RGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDrknrkd 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517879254  183 ----HPDAERLLRSGQIAGVFPEgfkgvGKNYADRYKLQrfGRGGFVSAAVRTGVPIIPCSIV 241
Cdd:pfam01553  76 aagtLEYLVELLREGKLVVIFPE-----GTRSREGELLP--FKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 124-243 1.78e-15

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 71.62  E-value: 1.78e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254   124 ALIVANHAGtvPLDGLMLQLAIHDKHPShraLRLLAADLIFELPLLGALARKAGH----------TLACHPDAERLLRSG 193
Cdd:smart00563   1 ALVVANHQS--FLDPLVLSALLPRKLGR---VRFVAKKELFYVPLLGWLLRLLGAifidrsngrkARAALREAVELLKEG 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 517879254   194 QIAGVFPEGFKGVGKnyadryKLQRFgRGGFVSAAVRTGVPIIPCSIVGS 243
Cdd:smart00563  76 EWLLIFPEGTRSRPG------KLLPF-KKGAARLALEAGVPIVPVAIRGT 118
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 108-241 1.53e-11

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 61.21  E-value: 1.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254  108 FRVETTGIENIPATGGALIVANHAGTvpLDGLMLQLAIHdkhpshRALRLLAADLIFELPLLGALARKAG------HTLA 181
Cdd:TIGR00530   2 LKVEVVGPENLPAKSPVLVVANHQSN--LDPLTLSAAFP------PPIVFIAKKELKWIPFFGIMLWLTGaifidrENIR 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517879254  182 CHPDAER----LLRSGQIAGVFPEGFKGVGKnyadryKLQRFGRGGFVSAAvRTGVPIIPCSIV 241
Cdd:TIGR00530  74 AIATALKaaieVLKQGRSIGVFPEGTRSRGR------DILPFKKGAFHIAI-KAGVPILPVVLS 130
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 100-242 3.45e-11

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 64.56  E-value: 3.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254  100 LRPLSDIWFRVETTGIENIPATGGALIVANHAGTVplDGLMLQLAihdkhpSHRALRLLAADLIFELPLLGALARKAGhT 179
Cdd:PRK08633  419 LLLLMHTRYRLRVEGRENIPAKGGALLLGNHVSWI--DWALLQAA------SPRPIRFVMERSIYEKWYLKWFFKLFG-V 489

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517879254  180 LACHPDAER--------LLRSGQIAGVFPEGfkGVGKNyadrYKLQRFgRGGFVSAAVRTGVPIIPCSIVG 242
Cdd:PRK08633  490 IPISSGGSKeslefirkALDDGEVVCIFPEG--AITRN----GQLNEF-KRGFELIVKGTDVPIIPFYIRG 553
 
Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 103-327 8.63e-39

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 136.65  E-value: 8.63e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 103 LSDIWFRVETTGIENIPATGGALIVANHaGTVPLDGLMLQLAIHDKHPShRALRLLAADLIFELPLLGALARKAGHTLAC 182
Cdd:cd07987    1 HRKYFRVYEVRGLENIPDEGPALLVHPH-GGLPIDGALLAAAFLLLFPG-RLPRALADHFLFPLPGLRDLLRRLGAVPGS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 183 HPDAERLLRSGQIAGVFPEGFKGVGKNYADRYKLQRFGRGGFVSAAVRTGVPIIPCSIVGSEEIYPKLAD-----IKPLA 257
Cdd:cd07987   79 RENCVRLLREGELVLIFPGGAREALKSKREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDpdgpvGKRLF 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 258 RLLGLPYfpvtptfphlgplgavplPSKWYIEFGEPIATTAFEPEDADDPmTMFEVTDQVRETIQQTLYK 327
Cdd:cd07987  159 RLLPLPR------------------RLPLYPVFGEPIVVPRPPIPDPPDE-DVEELHQKYIAALRELIEK 209
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 108-332 1.66e-26

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 104.32  E-value: 1.66e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 108 FRVETTGIENIPATGGALIVANHAGTvpLDGLMLQLAIhdkhpsHRALRLLAADLIFELPLLGALARKAGH--------- 178
Cdd:COG0204   29 VRVRVEGLENLPADGPVLIVANHQSW--LDILLLLAAL------PRPVRFVAKKELFKIPLLGWLLRALGAipvdrskrr 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 179 ----TLAchpDAERLLRSGQIAGVFPEGfkgvgkNYADRYKLQRFGRGGFVsAAVRTGVPIIPCSIVGSEEIYPKladik 254
Cdd:COG0204  101 aalrALR---QAVEALKAGESLVIFPEG------TRSPDGRLLPFKTGAAR-LALEAGVPIVPVAIDGTERALPK----- 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517879254 255 plarllglpyfpvtptfphlgplGAVPLPSKWYIEFGEPIATTAFEPEDADdpmtmfEVTDQVRETIQQTLYKLLAKR 332
Cdd:COG0204  166 -----------------------GFLPRPGKVTVRIGPPIDPSDLEGEDRR------ELAERLRAAIEALLAELRAEA 214
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 103-318 2.24e-23

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 95.03  E-value: 2.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 103 LSDIWFRVETTGIENIPATGGALIVANHAGTvpLDGLMLQLAIHDKhpshraLRLLAADLIFELPLLGALARKAGH---- 178
Cdd:cd07989    5 LRLLGVRVRVEGLENLPPKGPVIIVANHQSY--LDPLVLGAALPRP------IRFVAKKELFKIPFLGWLLRLLGAipid 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 179 ------TLACHPDAERLLRSGQIAGVFPEGFKGVGKnyadryKLQRFgRGGFVSAAVRTGVPIIPCSIVGSEEIYPKlad 252
Cdd:cd07989   77 rgngrsAREALREAIEALKEGESVVIFPEGTRSRDG------ELLPF-KSGAFRLAKEAGVPIVPVAISGTWGSLPK--- 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517879254 253 ikplarllglpyfpvtptfphlgpLGAVPLPSKWYIEFGEPIATTAFEPEDADDPmtmfEVTDQVR 318
Cdd:cd07989  147 ------------------------GKKLPRPGRVTVRIGEPIPPEGLELAEEDRK----ELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 109-241 1.42e-21

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 88.49  E-value: 1.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254  109 RVETTGIENIPATGGALIVANHAGtvPLDGLMLQLAIHDkhpSHRALRLLAADLIFELPLLGALARKAGHTLAC------ 182
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQS--YLDVLLLSLALYK---RGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDrknrkd 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517879254  183 ----HPDAERLLRSGQIAGVFPEgfkgvGKNYADRYKLQrfGRGGFVSAAVRTGVPIIPCSIV 241
Cdd:pfam01553  76 aagtLEYLVELLREGKLVVIFPE-----GTRSREGELLP--FKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 124-243 1.78e-15

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 71.62  E-value: 1.78e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254   124 ALIVANHAGtvPLDGLMLQLAIHDKHPShraLRLLAADLIFELPLLGALARKAGH----------TLACHPDAERLLRSG 193
Cdd:smart00563   1 ALVVANHQS--FLDPLVLSALLPRKLGR---VRFVAKKELFYVPLLGWLLRLLGAifidrsngrkARAALREAVELLKEG 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 517879254   194 QIAGVFPEGFKGVGKnyadryKLQRFgRGGFVSAAVRTGVPIIPCSIVGS 243
Cdd:smart00563  76 EWLLIFPEGTRSRPG------KLLPF-KKGAARLALEAGVPIVPVAIRGT 118
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 108-241 1.53e-11

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 61.21  E-value: 1.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254  108 FRVETTGIENIPATGGALIVANHAGTvpLDGLMLQLAIHdkhpshRALRLLAADLIFELPLLGALARKAG------HTLA 181
Cdd:TIGR00530   2 LKVEVVGPENLPAKSPVLVVANHQSN--LDPLTLSAAFP------PPIVFIAKKELKWIPFFGIMLWLTGaifidrENIR 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517879254  182 CHPDAER----LLRSGQIAGVFPEGFKGVGKnyadryKLQRFGRGGFVSAAvRTGVPIIPCSIV 241
Cdd:TIGR00530  74 AIATALKaaieVLKQGRSIGVFPEGTRSRGR------DILPFKKGAFHIAI-KAGVPILPVVLS 130
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 100-322 2.72e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 61.89  E-value: 2.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 100 LRPLSDIWFR-VETTGIENIPATGGALIVANHAGTVpLDGLMLQLAIHDKhpshraLRLLAADLIFELPLLGALARKAG- 177
Cdd:cd07992    5 SRVILRIYFRrITVVGRENVPKDGPVIFLGNHPNAL-IDPLLLAATLRRP------VRFLAKADLFKNPLIGWLLESFGa 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 178 ------HTLACHPDAE-----------RLLRSGQIAGVFPEGfkgvgkNYADRYKLQRFgRGGFVSAA------VRTGVP 234
Cdd:cd07992   78 ipvyrpKDLARGGIGKisnaavfdavgEALKAGGAIGIFPEG------GSHDRPRLLPL-KAGAARMAlealeaGQKDVK 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 235 IIPCSIVgseeiypkladikplarllglpYFPvtptfPHLgplgavpLPSKWYIEFGEPIATTAFEpEDADDPMTMFEVT 314
Cdd:cd07992  151 IVPVGLN----------------------YED-----KSR-------FRSRVLVEFGKPISVSAFE-EAEASRDVEKKLI 195


                 ....*...
gi 517879254 315 DQVRETIQ 322
Cdd:cd07992  196 NQLEAELE 203
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 100-242 3.45e-11

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 64.56  E-value: 3.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254  100 LRPLSDIWFRVETTGIENIPATGGALIVANHAGTVplDGLMLQLAihdkhpSHRALRLLAADLIFELPLLGALARKAGhT 179
Cdd:PRK08633  419 LLLLMHTRYRLRVEGRENIPAKGGALLLGNHVSWI--DWALLQAA------SPRPIRFVMERSIYEKWYLKWFFKLFG-V 489

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517879254  180 LACHPDAER--------LLRSGQIAGVFPEGfkGVGKNyadrYKLQRFgRGGFVSAAVRTGVPIIPCSIVG 242
Cdd:PRK08633  490 IPISSGGSKeslefirkALDDGEVVCIFPEG--AITRN----GQLNEF-KRGFELIVKGTDVPIIPFYIRG 553
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 99-248 1.31e-07

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 51.65  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254  99 ALRPLSDIW--------FRVETTGIENIPATG-GALIVANHAGTVPLDGLmLQLAihdkhpshRALRLLAADLIFELPLL 169
Cdd:PLN02901  18 AQHFINKVWatlstspfYKIEVEGLENLPSPDePAVYVSNHQSFLDIYTL-FHLG--------RPFKFISKTSIFLIPII 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 170 GALARKAGHT----------LACHPDAERLLRSGQIAGVFPEGFKGvgknyADRyKLQRFGRGGFvSAAVRTGVPIIPCS 239
Cdd:PLN02901  89 GWAMYMTGHIplkrmdrrsqLECLKRCMELLKKGASVFFFPEGTRS-----KDG-KLAAFKKGAF-SVAAKTGVPVVPIT 161


                 ....*....
gi 517879254 240 IVGSEEIYP 248
Cdd:PLN02901 162 LVGTGKIMP 170
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 100-240 5.15e-06

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 46.25  E-value: 5.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 100 LRPLSDIWFRVETTGIENIPATGGALIVANHagTVPLDGLMLQLAIHDKHPsHRALRLLAADLIFELPLLGAL------- 172
Cdd:cd06551    4 LLLNFFGFVRLEVKGPPPPPGGGPVLFVSNH--SSWWDGLILFLLLERGLR-RDVYGLMDEELLERYPFFTRLgafsvdr 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517879254 173 --ARKAGHTLAchpDAERLLRSGQIA-GVFPEGFKGvgknyADRYKLQRFgRGGFVSAAVRTGVPIIPCSI 240
Cdd:cd06551   81 dsPRSAAKSLK---YVARLLSKPGSVvWIFPEGTRT-----RRDKRPLQF-KPGVAHLAEKAGVPIVPVAL 142
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 105-264 8.27e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 46.09  E-value: 8.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 105 DIWFRVETTGIENIPATGGALIVANHAgTVPLDGLMLQLAIHDKHPShraLRLLAADLIFELPLL-------------GA 171
Cdd:cd07986    5 NVQLEVDVSGLENIPKDGPVVIVANHP-FGILDGLILADLLGSVRPD---VRILANQLLSKIPELrdlfipvdplegrAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 172 LARKAGHTLACHpdaeRLLRSGQIAGVFPEGFKGvgknyadRYKLQrFGR-------GGFVSAAVRTGVPIIPCSIVGSE 244
Cdd:cd07986   81 LAKNRESLREAL----RHLKNGGALIIFPAGRVS-------TASPP-FGRvsdrpwnPFVARLARKAKAPVVPVYFSGRN 148

                        170       180
                 ....*....|....*....|.
gi 517879254 245 EIYPKLAD-IKPLARLLGLPY 264
Cdd:cd07986  149 SRLFYLAGlIHPTLRTLLLPR 169
COG3176 COG3176
Putative hemolysin [General function prediction only];
108-237 8.72e-05

Putative hemolysin [General function prediction only];


Pssm-ID: 442409  Cd Length: 270  Bit Score: 43.49  E-value: 8.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517879254 108 FRVETTGIENIPATGGALIVANHAgTVPLDGLMLQLAIHDKHPS---------HRALRLLAADLIFELPLLGALARKAgh 178
Cdd:COG3176   57 LEVPEGDLDRIDADGHLLVVANHP-LGILDGLALLKLVGTVRPDyrilandlaLRIPGGFYSELEFPVDPFNLETLKA-- 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 517879254 179 tlachpdAERLLRSGQIAGVFPEGfkGVGKNYADRYKLQrfgRGGFVSAAVRTGVPIIP 237
Cdd:COG3176  134 -------ARRHLLEGGRSCVFPAG--RVSGARRVIDLLW---SGLAAKLARKAGAPVVP 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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