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Conserved domains on  [gi|517913054|ref|WP_019083262|]
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MULTISPECIES: P-loop NTPase fold protein [Enterobacterales]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KAP_NTPase super family cl46386
KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases ...
8-292 2.74e-06

KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side.


The actual alignment was detected with superfamily member COG4928:

Pssm-ID: 480726  Cd Length: 386  Bit Score: 49.91  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054   8 EQLKQLLTEKDNK---VIALSGKWGTGKSY---MWQQVKNSSADETVkgaLY--ASLFglSGIEQVKTKLIQSMVPAIKA 79
Cdd:COG4928   15 ESLANLIKSSDADeplVIGLDGEWGSGKTSflnLIEKELESNEKVIV---VYfnAWLY--DGEEDLLAALLSEIAAELEK 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054  80 NPKLWEGAKQTVKSGVKVLEGFHKGFGALNDLNLVFAPAI---------LRQKLI--VLDDIERKHEKLDIDEVLGFIDE 148
Cdd:COG4928   90 KKKKDKKAAKKLKKYAKRLSKLALKAGLLGGPAEAVAEALkallkkeykSKKKSIeaFREELEELLKELKGKRLVVFIDD 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054 149 ------------------FTQQHGCRFVLILNSDQLAK---------RDVWDLLrEKVVDQEIRLTTSSTE----AFDIA 197
Cdd:COG4928  170 ldrcepdeaievleliklFFDFPNVVFVLAFDREILEHalkerygedIDAREYL-EKIIQVPFRLPPLSNEllilELDRL 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054 198 IGYTASGYAEQIRTSVVSCGVTNIRIISKIIKVVNRILGERQELTDAVLWRVIPSTVLLAAIHYKGI--EDGPDFDFVLT 275
Cdd:COG4928  249 LELLLSALLEALLALLLLRALAESISSLRAEFLLLLLLLKLELLLALLVLLLKLELLLENLLLAALLllLDELELKKLLR 328
                        330
                 ....*....|....*..
gi 517913054 276 QDSENFASFFDSKEEVA 292
Cdd:COG4928  329 EDVASRASLYFINAELA 345
 
Name Accession Description Interval E-value
COG4928 COG4928
Predicted P-loop ATPase, KAP-like [General function prediction only];
8-292 2.74e-06

Predicted P-loop ATPase, KAP-like [General function prediction only];


Pssm-ID: 443956  Cd Length: 386  Bit Score: 49.91  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054   8 EQLKQLLTEKDNK---VIALSGKWGTGKSY---MWQQVKNSSADETVkgaLY--ASLFglSGIEQVKTKLIQSMVPAIKA 79
Cdd:COG4928   15 ESLANLIKSSDADeplVIGLDGEWGSGKTSflnLIEKELESNEKVIV---VYfnAWLY--DGEEDLLAALLSEIAAELEK 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054  80 NPKLWEGAKQTVKSGVKVLEGFHKGFGALNDLNLVFAPAI---------LRQKLI--VLDDIERKHEKLDIDEVLGFIDE 148
Cdd:COG4928   90 KKKKDKKAAKKLKKYAKRLSKLALKAGLLGGPAEAVAEALkallkkeykSKKKSIeaFREELEELLKELKGKRLVVFIDD 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054 149 ------------------FTQQHGCRFVLILNSDQLAK---------RDVWDLLrEKVVDQEIRLTTSSTE----AFDIA 197
Cdd:COG4928  170 ldrcepdeaievleliklFFDFPNVVFVLAFDREILEHalkerygedIDAREYL-EKIIQVPFRLPPLSNEllilELDRL 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054 198 IGYTASGYAEQIRTSVVSCGVTNIRIISKIIKVVNRILGERQELTDAVLWRVIPSTVLLAAIHYKGI--EDGPDFDFVLT 275
Cdd:COG4928  249 LELLLSALLEALLALLLLRALAESISSLRAEFLLLLLLLKLELLLALLVLLLKLELLLENLLLAALLllLDELELKKLLR 328
                        330
                 ....*....|....*..
gi 517913054 276 QDSENFASFFDSKEEVA 292
Cdd:COG4928  329 EDVASRASLYFINAELA 345
KAP_NTPase pfam07693
KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases ...
21-168 3.66e-03

KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side.


Pssm-ID: 462231  Cd Length: 293  Bit Score: 39.67  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054   21 VIALSGKWGTGKSYM----------------------WQQVKNSSADETVKGALYASLFGLSGIEQVKTkLIQSMVPAIK 78
Cdd:pfam07693  22 VIGLYGQWGSGKTSFlnllekelnefneefiivyfnpWSFSGQDDLDAELFSALADALEEEYSQLATKL-LIGKKLPALG 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054   79 ANPKL-WEG--AKQTVKSGVKVLEGFH-------------KGFGALNDLNlvfapailRQKLIVLDDIERKHEK-----L 137
Cdd:pfam07693 101 IDAKIgLIFgvAIILALTGLVVAIEEPmkklqteieelrsDIESTLKDLN--------KRIVIIIDDLDRCEPEeivllL 172
                         170       180       190
                  ....*....|....*....|....*....|.
gi 517913054  138 DIDEVLGFIDEFTqqhgcrFVLILNSDQLAK 168
Cdd:pfam07693 173 EAVRLLFDFPNVV------FILAADEEILKK 197
 
Name Accession Description Interval E-value
COG4928 COG4928
Predicted P-loop ATPase, KAP-like [General function prediction only];
8-292 2.74e-06

Predicted P-loop ATPase, KAP-like [General function prediction only];


Pssm-ID: 443956  Cd Length: 386  Bit Score: 49.91  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054   8 EQLKQLLTEKDNK---VIALSGKWGTGKSY---MWQQVKNSSADETVkgaLY--ASLFglSGIEQVKTKLIQSMVPAIKA 79
Cdd:COG4928   15 ESLANLIKSSDADeplVIGLDGEWGSGKTSflnLIEKELESNEKVIV---VYfnAWLY--DGEEDLLAALLSEIAAELEK 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054  80 NPKLWEGAKQTVKSGVKVLEGFHKGFGALNDLNLVFAPAI---------LRQKLI--VLDDIERKHEKLDIDEVLGFIDE 148
Cdd:COG4928   90 KKKKDKKAAKKLKKYAKRLSKLALKAGLLGGPAEAVAEALkallkkeykSKKKSIeaFREELEELLKELKGKRLVVFIDD 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054 149 ------------------FTQQHGCRFVLILNSDQLAK---------RDVWDLLrEKVVDQEIRLTTSSTE----AFDIA 197
Cdd:COG4928  170 ldrcepdeaievleliklFFDFPNVVFVLAFDREILEHalkerygedIDAREYL-EKIIQVPFRLPPLSNEllilELDRL 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054 198 IGYTASGYAEQIRTSVVSCGVTNIRIISKIIKVVNRILGERQELTDAVLWRVIPSTVLLAAIHYKGI--EDGPDFDFVLT 275
Cdd:COG4928  249 LELLLSALLEALLALLLLRALAESISSLRAEFLLLLLLLKLELLLALLVLLLKLELLLENLLLAALLllLDELELKKLLR 328
                        330
                 ....*....|....*..
gi 517913054 276 QDSENFASFFDSKEEVA 292
Cdd:COG4928  329 EDVASRASLYFINAELA 345
KAP_NTPase pfam07693
KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases ...
21-168 3.66e-03

KAP family P-loop domain; The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side.


Pssm-ID: 462231  Cd Length: 293  Bit Score: 39.67  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054   21 VIALSGKWGTGKSYM----------------------WQQVKNSSADETVKGALYASLFGLSGIEQVKTkLIQSMVPAIK 78
Cdd:pfam07693  22 VIGLYGQWGSGKTSFlnllekelnefneefiivyfnpWSFSGQDDLDAELFSALADALEEEYSQLATKL-LIGKKLPALG 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517913054   79 ANPKL-WEG--AKQTVKSGVKVLEGFH-------------KGFGALNDLNlvfapailRQKLIVLDDIERKHEK-----L 137
Cdd:pfam07693 101 IDAKIgLIFgvAIILALTGLVVAIEEPmkklqteieelrsDIESTLKDLN--------KRIVIIIDDLDRCEPEeivllL 172
                         170       180       190
                  ....*....|....*....|....*....|.
gi 517913054  138 DIDEVLGFIDEFTqqhgcrFVLILNSDQLAK 168
Cdd:pfam07693 173 EAVRLLFDFPNVV------FILAADEEILKK 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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