|
Name |
Accession |
Description |
Interval |
E-value |
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
1-429 |
2.66e-116 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 343.74 E-value: 2.66e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 1 MKKSFIqksivclLTFVLMigFIQKPAAAAENIDINANAVILIDAETGKILYEKNAETVLGIASMTKMMTEYLLLEAVKE 80
Cdd:COG1686 1 MKKLLL-------LALLLL--LAAAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 81 GKVKWDQTFTISPELSKMshddDLSNVYLRVDSAYTVEDLYSAMAIESANAATVAIAEIVAGSEANFVKLMNEKAEELGL 160
Cdd:COG1686 72 GKISLDDKVTVSEEAART----GGSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGM 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 161 GDFKFVNSTGLNNrdlakhfpdvvggaeEENVMSARAVAKLAYQILKDFPEVLETSSIPEKTFAEGTKdrFVMDNWNWML 240
Cdd:COG1686 148 TNTHFVNPTGLPD---------------PGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNGRG--ITLRNTNRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 241 egyrdiadrysyyqqFTYEGLDGLKTGSTNFAGFCFTGTASRDGVRYITVVMGTKSQTERFVETKKLLDFAfnnFSKEEL 320
Cdd:COG1686 211 ---------------GRYPGVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYG---FPKGEA 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 321 VPAEYVVKGTetvpvskgkedqvkvhsadaissivtpaeqenfdtvvkldkdklneegaLTAPIKKGDKIGTVTIQFkDG 400
Cdd:COG1686 273 LKAEVVLDGP-------------------------------------------------LKAPVKKGQVVGTLVVTL-DG 302
|
410 420
....*....|....*....|....*....
gi 517987028 401 EAVYlssegqksmTVDLIAAENVEKANWF 429
Cdd:COG1686 303 KTIA---------EVPLVAAEDVEKAGFF 322
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
34-295 |
1.61e-81 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 251.54 E-value: 1.61e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 34 DINANAVILIDAETGKILYEKNAETVLGIASMTKMMTEYLLLEAVKEGKVKWDQTFTISpELSKMSHDDDLSNVYLRVDS 113
Cdd:pfam00768 5 EIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTIS-EDAWATGNPGSSNIFLKPGS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 114 AYTVEDLYSAMAIESANAATVAIAEIVAGSEANFVKLMNEKAEELGLGDFKFVNSTGLNNrdlakhfpdvvggaeEENVM 193
Cdd:pfam00768 84 QVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDA---------------HGQYS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 194 SARAVAKLAYQILKDFPEVLETSSIPEKTFAEgtkdrfvMDNWNWMLEGyRDIADRYSYyqqftyegLDGLKTGSTNFAG 273
Cdd:pfam00768 149 SARDMAILAKALIKDLPEELSITKEKSFTFRG-------INKINQRNRN-GLLWDKTWN--------VDGLKTGYTNEAG 212
|
250 260
....*....|....*....|..
gi 517987028 274 FCFTGTASRDGVRYITVVMGTK 295
Cdd:pfam00768 213 YCLVASATKGGMRLISVVMGAF 234
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
13-295 |
1.77e-49 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 172.47 E-value: 1.77e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 13 LLTFVLMIGFIQKPAAAAEN--IDI-------------NANAVILIdAETGKILYEKNAETVLGIASMTKMMTEYLLLEA 77
Cdd:NF038258 1 IVSLLLLSTIITPPASAAAEtpVEIanqegyqnlseqyNPEGAIVT-TQTGQILYDYHGNKKWDPASMTKLMTMYLTLEA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 78 VKEGKVKWDQTFTISPELSKMSHDDDLSNVYLRVDSAYTVEDLYSAMAIESANAATVAIAEIVAGSEANFVKLMNEKAEE 157
Cdd:NF038258 80 IKKGKLSLNDKVKITSDYEKMSTLPNLSTFPLKPGQTYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 158 LGLGDFKFVNSTGLNNRdLAKHFPDVVGGAEEENVMSARAVAKLAYQILKDFPEVLETSSIPEKTfAEGTKdrfvMDNWN 237
Cdd:NF038258 160 LGMKHTHFTNPSGADNN-LLKPYAPKKYKDETKSKSTAKDMAILSQHLIKKHPKILKYTKLTADT-QHGVT----LYTTN 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 517987028 238 WMLEGyrdiadrysyyQQFTYEGLDGLKTGSTNfAGFCFTGTASRDGVRYITVVMGTK 295
Cdd:NF038258 234 LSLPG-----------QPMSLKGTDGLKTGTSD-EGYNLALTTKRDGLRINQVIMNVG 279
|
|
| PRK10001 |
PRK10001 |
serine-type D-Ala-D-Ala carboxypeptidase; |
22-455 |
2.08e-46 |
|
serine-type D-Ala-D-Ala carboxypeptidase;
Pssm-ID: 182189 [Multi-domain] Cd Length: 400 Bit Score: 165.17 E-value: 2.08e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 22 FIQKPAA-AAENI----DINANAVILIDAETGKILYEKNAETVLGIASMTKMMTEYLLLEAVKEGKVKWDQTFTI----- 91
Cdd:PRK10001 19 FLFAPTAfAAEQTveapSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVgkdaw 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 92 ---SPELSKMshdddlSNVYLRVDSAYTVEDLYSAMAIESANAATVAIAEIVAGSEANFVKLMNEKAEELGLGDFKFVNS 168
Cdd:PRK10001 99 atgNPALRGS------SVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 169 TGLnnrDLAKHFPdvvggaeeenvmSARAVAKLAYQILKDFPEvlETSSIPEKTFaegTKDRFVMDNWNWMLEGyrdiad 248
Cdd:PRK10001 173 HGL---DAPGQFS------------TARDMALLGKALIHDVPE--EYAIHKEKEF---TFNKIRQPNRNRLLWS------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 249 rysyyqqfTYEGLDGLKTGSTNFAGFCFTGTASRDGVRYITVVMGTKSQTERFVETKKLLDFAFNNFskEELVP----AE 324
Cdd:PRK10001 227 --------SNLNVDGMKTGTTAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFF--ETVTPikpdAT 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 325 YVvkgteTVPVSKGKEDQVKVHSADAISSIVTPAEQENFDTVVKLDkdklneEGALTAPIKKGDKIGTVTIQFKDgeavy 404
Cdd:PRK10001 297 FV-----TQRVWFGDKSEVNLGAGEAGSVTIPRGQLKNLKASYTLT------EPQLTAPLKKGQVVGTIDFQLNG----- 360
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 517987028 405 lSSEGQKSmtvdLIAAENVEKanwfvlmmrgiGGFFGDLWGSVSSTVKGWF 455
Cdd:PRK10001 361 -KSIEQRP----LIVMENVEE-----------GGFFSRMWDFVMMKFHQWF 395
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
315-425 |
6.40e-14 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 67.24 E-value: 6.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 315 FSKEELVPAEYVVKgteTVPVSKGKEDQVKVHSADAISSIVTPAEQENFDTVVKLDKDKLNeegaltAPIKKGDKIGTVT 394
Cdd:smart00936 1 FETVKLYKKGQVVG---TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELE------APIKKGQVVGTLV 71
|
90 100 110
....*....|....*....|....*....|.
gi 517987028 395 IQfkdgeavylsSEGQKSMTVDLIAAENVEK 425
Cdd:smart00936 72 VT----------LDGKLIGEVPLVALEDVEK 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
1-429 |
2.66e-116 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 343.74 E-value: 2.66e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 1 MKKSFIqksivclLTFVLMigFIQKPAAAAENIDINANAVILIDAETGKILYEKNAETVLGIASMTKMMTEYLLLEAVKE 80
Cdd:COG1686 1 MKKLLL-------LALLLL--LAAAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 81 GKVKWDQTFTISPELSKMshddDLSNVYLRVDSAYTVEDLYSAMAIESANAATVAIAEIVAGSEANFVKLMNEKAEELGL 160
Cdd:COG1686 72 GKISLDDKVTVSEEAART----GGSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGM 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 161 GDFKFVNSTGLNNrdlakhfpdvvggaeEENVMSARAVAKLAYQILKDFPEVLETSSIPEKTFAEGTKdrFVMDNWNWML 240
Cdd:COG1686 148 TNTHFVNPTGLPD---------------PGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPNGRG--ITLRNTNRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 241 egyrdiadrysyyqqFTYEGLDGLKTGSTNFAGFCFTGTASRDGVRYITVVMGTKSQTERFVETKKLLDFAfnnFSKEEL 320
Cdd:COG1686 211 ---------------GRYPGVDGLKTGYTDAAGYCLVASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYG---FPKGEA 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 321 VPAEYVVKGTetvpvskgkedqvkvhsadaissivtpaeqenfdtvvkldkdklneegaLTAPIKKGDKIGTVTIQFkDG 400
Cdd:COG1686 273 LKAEVVLDGP-------------------------------------------------LKAPVKKGQVVGTLVVTL-DG 302
|
410 420
....*....|....*....|....*....
gi 517987028 401 EAVYlssegqksmTVDLIAAENVEKANWF 429
Cdd:COG1686 303 KTIA---------EVPLVAAEDVEKAGFF 322
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
34-295 |
1.61e-81 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 251.54 E-value: 1.61e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 34 DINANAVILIDAETGKILYEKNAETVLGIASMTKMMTEYLLLEAVKEGKVKWDQTFTISpELSKMSHDDDLSNVYLRVDS 113
Cdd:pfam00768 5 EIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTIS-EDAWATGNPGSSNIFLKPGS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 114 AYTVEDLYSAMAIESANAATVAIAEIVAGSEANFVKLMNEKAEELGLGDFKFVNSTGLNNrdlakhfpdvvggaeEENVM 193
Cdd:pfam00768 84 QVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDA---------------HGQYS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 194 SARAVAKLAYQILKDFPEVLETSSIPEKTFAEgtkdrfvMDNWNWMLEGyRDIADRYSYyqqftyegLDGLKTGSTNFAG 273
Cdd:pfam00768 149 SARDMAILAKALIKDLPEELSITKEKSFTFRG-------INKINQRNRN-GLLWDKTWN--------VDGLKTGYTNEAG 212
|
250 260
....*....|....*....|..
gi 517987028 274 FCFTGTASRDGVRYITVVMGTK 295
Cdd:pfam00768 213 YCLVASATKGGMRLISVVMGAF 234
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
13-295 |
1.77e-49 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 172.47 E-value: 1.77e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 13 LLTFVLMIGFIQKPAAAAEN--IDI-------------NANAVILIdAETGKILYEKNAETVLGIASMTKMMTEYLLLEA 77
Cdd:NF038258 1 IVSLLLLSTIITPPASAAAEtpVEIanqegyqnlseqyNPEGAIVT-TQTGQILYDYHGNKKWDPASMTKLMTMYLTLEA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 78 VKEGKVKWDQTFTISPELSKMSHDDDLSNVYLRVDSAYTVEDLYSAMAIESANAATVAIAEIVAGSEANFVKLMNEKAEE 157
Cdd:NF038258 80 IKKGKLSLNDKVKITSDYEKMSTLPNLSTFPLKPGQTYTIKELLKQTALASSNAAALILAEKVSGNTSKFTDRMNEKAKA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 158 LGLGDFKFVNSTGLNNRdLAKHFPDVVGGAEEENVMSARAVAKLAYQILKDFPEVLETSSIPEKTfAEGTKdrfvMDNWN 237
Cdd:NF038258 160 LGMKHTHFTNPSGADNN-LLKPYAPKKYKDETKSKSTAKDMAILSQHLIKKHPKILKYTKLTADT-QHGVT----LYTTN 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 517987028 238 WMLEGyrdiadrysyyQQFTYEGLDGLKTGSTNfAGFCFTGTASRDGVRYITVVMGTK 295
Cdd:NF038258 234 LSLPG-----------QPMSLKGTDGLKTGTSD-EGYNLALTTKRDGLRINQVIMNVG 279
|
|
| PRK10001 |
PRK10001 |
serine-type D-Ala-D-Ala carboxypeptidase; |
22-455 |
2.08e-46 |
|
serine-type D-Ala-D-Ala carboxypeptidase;
Pssm-ID: 182189 [Multi-domain] Cd Length: 400 Bit Score: 165.17 E-value: 2.08e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 22 FIQKPAA-AAENI----DINANAVILIDAETGKILYEKNAETVLGIASMTKMMTEYLLLEAVKEGKVKWDQTFTI----- 91
Cdd:PRK10001 19 FLFAPTAfAAEQTveapSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVgkdaw 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 92 ---SPELSKMshdddlSNVYLRVDSAYTVEDLYSAMAIESANAATVAIAEIVAGSEANFVKLMNEKAEELGLGDFKFVNS 168
Cdd:PRK10001 99 atgNPALRGS------SVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 169 TGLnnrDLAKHFPdvvggaeeenvmSARAVAKLAYQILKDFPEvlETSSIPEKTFaegTKDRFVMDNWNWMLEGyrdiad 248
Cdd:PRK10001 173 HGL---DAPGQFS------------TARDMALLGKALIHDVPE--EYAIHKEKEF---TFNKIRQPNRNRLLWS------ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 249 rysyyqqfTYEGLDGLKTGSTNFAGFCFTGTASRDGVRYITVVMGTKSQTERFVETKKLLDFAFNNFskEELVP----AE 324
Cdd:PRK10001 227 --------SNLNVDGMKTGTTAGAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFF--ETVTPikpdAT 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 325 YVvkgteTVPVSKGKEDQVKVHSADAISSIVTPAEQENFDTVVKLDkdklneEGALTAPIKKGDKIGTVTIQFKDgeavy 404
Cdd:PRK10001 297 FV-----TQRVWFGDKSEVNLGAGEAGSVTIPRGQLKNLKASYTLT------EPQLTAPLKKGQVVGTIDFQLNG----- 360
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 517987028 405 lSSEGQKSmtvdLIAAENVEKanwfvlmmrgiGGFFGDLWGSVSSTVKGWF 455
Cdd:PRK10001 361 -KSIEQRP----LIVMENVEE-----------GGFFSRMWDFVMMKFHQWF 395
|
|
| dacD |
PRK11397 |
serine-type D-Ala-D-Ala carboxypeptidase DacD; |
13-429 |
2.75e-34 |
|
serine-type D-Ala-D-Ala carboxypeptidase DacD;
Pssm-ID: 183117 [Multi-domain] Cd Length: 388 Bit Score: 132.25 E-value: 2.75e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 13 LLTFVLMIGFIQKPAAAAENID-------INANAVILIDAETGKILYEKNAETVLGIASMTKMMTEYLLLEAVKEGKVKW 85
Cdd:PRK11397 5 LIIAASLFAFNLSSAFAAENIPfspqppaIDAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRITP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 86 DQTFTISPELSKMSHD--DDLSNVYLRVDSAYTVEDLYSAMAIESANAATVAIAEIVAGSEANFVKLMNEKAEELGLGDf 163
Cdd:PRK11397 85 DDIVTVGRDAWAKDNPvfVGSSLMFLKEGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLHLKD- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 164 kfvnstglnnrdlaKHFPDVVGGAEEENVMSARAVAKLAYQILKDFPEVLETSSipEKTFaegtkdrfvmdNWNWMLEGY 243
Cdd:PRK11397 164 --------------THFETVHGLDAPGQHSSAYDLAVLSRAIIHGEPEFYHMYS--EKSL-----------TWNGITQQN 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 244 RD--IADRYSYyqqftyegLDGLKTGSTNFAGFCFTGTASRDGVRYITVVMGTKSQTERFVETKKLLDFAFNNFSKEELV 321
Cdd:PRK11397 217 RNglLWDKTMN--------VDGLKTGHTSGAGFNLIASAVDGQRRLIAVVMGADSAKGREEQARKLLRWGQQNFTTVQIL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 322 PAEYVVkGTETvpVSKGKEDQVKVHSADAISSIVTPAEQENFDTVVKLDKDKlneegaLTAPIKKGDKIGtvTIQFKDGE 401
Cdd:PRK11397 289 HRGKKV-GTER--IWYGDKENIALGTEQDFWMVLPKAEIPHIKAKYVLDGKE------LEAPISAHQRVG--EIELYDRD 357
|
410 420
....*....|....*....|....*...
gi 517987028 402 AVYLSsegqksmtVDLIAAENVEKANWF 429
Cdd:PRK11397 358 KQVAH--------WPLVTLESVGEGGMF 377
|
|
| PRK10793 |
PRK10793 |
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional |
34-403 |
5.53e-33 |
|
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
Pssm-ID: 182736 [Multi-domain] Cd Length: 403 Bit Score: 128.82 E-value: 5.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 34 DINANAVILIDAETGKILYEKNAETVLGIASMTKMMTEYLLLEAVKEGKVKWDQTFTISPELSKMSHDD--DLSNVYLRV 111
Cdd:PRK10793 43 QIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMKAGKFKETDLVTVGNDAWATGNPVfkGSSLMFLKP 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 112 DSAYTVEDLYSAMAIESANAATVAIAEIVAGSEANFVKLMNekaeelglgdfKFVNSTGLNNrdlaKHFPDVVGGAEEEN 191
Cdd:PRK10793 123 GMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMN-----------SYVNALGLKN----THFQTVHGLDADGQ 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 192 VMSARAVAKLAYQILKDFPEvlETSSIPEKTFaegTKDRFVMDNWNWMLEGyrdiadrysyyqqfTYEGLDGLKTGSTNF 271
Cdd:PRK10793 188 YSSARDMALIGQALIRDVPN--EYAIYKEKEF---TFNGIRQLNRNGLLWD--------------NSLNVDGIKTGHTDK 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 272 AGFCFTGTASRDGVRYITVVMGTKSQTERFVETKKLLDFAFNNFskeELVPAEYVVKGTETVPVSKGKEDQVKVHSADAI 351
Cdd:PRK10793 249 AGYNLVASATEGQMRLISAVMGGRTFKGRETESKKLLTWGFRFF---ETVNPLKVGKEFASEPVWFGDSDRASLGVDKDV 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 517987028 352 SSIVTPAEQENFDTVVKLDKDKLNeegaltAPIKKGDKIGTVTIQFkDGEAV 403
Cdd:PRK10793 326 YLTIPRGRMKDLKASYVLNTSELH------APLQKNQVVGTINFQL-DGKTI 370
|
|
| pbpG |
PRK11669 |
D-alanyl-D-alanine endopeptidase; Provisional |
6-275 |
1.22e-20 |
|
D-alanyl-D-alanine endopeptidase; Provisional
Pssm-ID: 236952 Cd Length: 306 Bit Score: 92.05 E-value: 1.22e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 6 IQKSIVCLLTFVLMIGFI-------QKPAAAAENIDINANAVILIDAETGKILYEKNAETVLGIASMTKMMTEYLLLEAv 78
Cdd:PRK11669 3 FRVSLLSLLLLLAGVPFApqavaktAAATTASQPQEIASGSAMVVDLNTNKVIYSSNPDLVVPIASITKLMTAMVVLDA- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 79 kegKVKWDQTFTIspelsKMSHDDDLSNVYLRV--DSAYTVEDLYSAMAIESANAATVAIAEIVAGSEANFVKLMNEKAE 156
Cdd:PRK11669 82 ---KLPLDEKLKV-----DISQTPEMKGVYSRVrlNSEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMNAKAK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 157 ELGLGDFKFVNSTGLNnrdlakhfpdvvggaeEENVMSARAVAKLaYQILKDFPEVLETSSIPEKT--FAEGT------- 227
Cdd:PRK11669 154 ALGMTNTRYVEPTGLS----------------IHNVSTARDLTKL-LIASKQYPLIGQLSTTREKTatFRKPNytlpfrn 216
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 517987028 228 KDRFVM-DNWNwmlegyrdIadrysyyqQFTyegldglKTGSTNFAGFC 275
Cdd:PRK11669 217 TNHLVYrDNWN--------I--------QLT-------KTGFTNAAGHC 242
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
315-425 |
6.40e-14 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 67.24 E-value: 6.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 315 FSKEELVPAEYVVKgteTVPVSKGKEDQVKVHSADAISSIVTPAEQENFDTVVKLDKDKLNeegaltAPIKKGDKIGTVT 394
Cdd:smart00936 1 FETVKLYKKGQVVG---TVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELE------APIKKGQVVGTLV 71
|
90 100 110
....*....|....*....|....*....|.
gi 517987028 395 IQfkdgeavylsSEGQKSMTVDLIAAENVEK 425
Cdd:smart00936 72 VT----------LDGKLIGEVPLVALEDVEK 92
|
|
| PBP5_C |
pfam07943 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
315-425 |
3.22e-11 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 429749 [Multi-domain] Cd Length: 91 Bit Score: 59.53 E-value: 3.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 315 FSKEELVPAEYVVKgteTVPVSKGKEDQVKVHSADAISSIVTPAEQENFDTVVKLDKDklneegaLTAPIKKGDKIGTVT 394
Cdd:pfam07943 1 FETKKLYKKGDVVK---KVKVWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKVTLKKP-------LEAPIKKGQVVGKLE 70
|
90 100 110
....*....|....*....|....*....|.
gi 517987028 395 IQFkdgeavylssEGQKSMTVDLIAAENVEK 425
Cdd:pfam07943 71 VYL----------DGKLIGEVPLVAKEDVEE 91
|
|
| PenP |
COG2367 |
Beta-lactamase class A [Defense mechanisms]; |
13-208 |
5.96e-11 |
|
Beta-lactamase class A [Defense mechanisms];
Pssm-ID: 441934 [Multi-domain] Cd Length: 276 Bit Score: 62.99 E-value: 5.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 13 LLTFVLMIGFIQKPAAAAENiDINANA--------VILIDAETGKiLYEKNAETVLGIASMTKMMTEYLLLEAVKEGKVK 84
Cdd:COG2367 3 LLALLLLAAAAAAPASALEA-ELAALEaalggrvgVYVLDLDTGE-TVGINADERFPAASTFKLPVLAAVLRQVDAGKLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 85 WDQTFTISPELsKMSHDDDLSnvYLRVDSAYTVEDLYSAMAIESANAATVAIAEIVaGSEAnfvklMNEKAEELGLGDFK 164
Cdd:COG2367 81 LDERVTLTPED-LVGGSGILQ--KLPDGTGLTLRELAELMITVSDNTATNLLLRLL-GPDA-----VNAFLRSLGLTDTR 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 517987028 165 FVNSTGLNNRDLakhfpdvvggAEEENVMSARAVAKLAYQILKD 208
Cdd:COG2367 152 LDRKEPDLNELP----------GDGRNTTTPRDMARLLAALYRG 185
|
|
| Beta-lactamase2 |
pfam13354 |
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ... |
44-201 |
1.32e-10 |
|
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.
Pssm-ID: 463854 [Multi-domain] Cd Length: 215 Bit Score: 60.75 E-value: 1.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 44 DAETGKiLYEKNAETVLGIASMTKMMTEYLLLEAVKEGKVKWDQTFTISPELsKMSHDDDLSnvYLRVDSAYTVEDLYSA 123
Cdd:pfam13354 6 DLDTGE-ELGINGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTAED-KVGGSGILQ--YLPDGSQLSLRDLLTL 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517987028 124 MAIESANAATVAIAEIVAGSEanfvklMNEKAEELGLgdfkfvNSTGLNNRDLAKHFPDvvggAEEENVMSARAVAKL 201
Cdd:pfam13354 82 MIAVSDNTATNLLIDRLGLEA------VNARLRALGL------RDTRLRRKLPDLRAAD----KGGTNTTTARDMAKL 143
|
|
| AmpC |
COG1680 |
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms]; |
27-245 |
1.05e-04 |
|
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];
Pssm-ID: 441286 [Multi-domain] Cd Length: 355 Bit Score: 44.29 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 27 AAAAENIDINANAVILIDAetGKILYEK-------------NAETVLGIASMTKMMTEYLLLEAVKEGKVKWDQtfTIS- 92
Cdd:COG1680 24 DAALAEGGIPGAAVAVVRD--GKVVYEKaygvadletgrpvTPDTLFRIASVTKSFTATAVLQLVEEGKLDLDD--PVSk 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 93 --PELSK-------------MSH----DDDLSNVY--LRVDSAYTVEDLYSAMA---IESA--------NAATVAIAEIV 140
Cdd:COG1680 100 ylPEFKLpddakrditvrhlLTHtsglPDYEPDPYdaADVARPYTPDDLLARLAalpLLFEpgtrfsysNLGYDLLGEII 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517987028 141 AG-SEANFVKLMNEK-AEELGLGDFKFVNSTGLNNRDLAKHFPDvvGGAEEEN------------VMSARAVAKLAYQIL 206
Cdd:COG1680 180 ERvTGQPLEDYLRERiFEPLGMTDTGFGLPDAEAARLAPGYEAD--GEVHDAPawlgavagagglFSTARDLARFGQALL 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 517987028 207 KDfPEVLETSSIPEKTFAEGTKDRFVMDNWN------WMLEGYRD 245
Cdd:COG1680 258 NG-GEWDGKRLLSPETLAEMTTPQVPSGDAGggyglgWWLNDDGG 301
|
|
| |
