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Conserved domains on  [gi|517994785|ref|WP_019164993|]
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antibiotic biosynthesis monooxygenase [Staphylococcus delphini]

Protein Classification

antibiotic biosynthesis monooxygenase family protein( domain architecture ID 926)

antibiotic biosynthesis monooxygenase family protein may be involved in the biosynthesis of several antibiotics; similar to Streptomyces ambofaciens anthrone oxidase-like protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ABM super family cl10022
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 66-136 3.70e-03

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


The actual alignment was detected with superfamily member pfam03992:

Pssm-ID: 447883  Cd Length: 74  Bit Score: 34.55  E-value: 3.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517994785   66 FHALISIPTTEDHKYQLEKKLESYLPHLDEYEGFNTYRLLKPL-QSNIYKVFLGFSSRKAYEDYKKSSAFRE 136
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLeDPDEYVVLEVWEDEAAFEAHLQSPHFKA 72
 
Name Accession Description Interval E-value
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 66-136 3.70e-03

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 34.55  E-value: 3.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517994785   66 FHALISIPTTEDHKYQLEKKLESYLPHLDEYEGFNTYRLLKPL-QSNIYKVFLGFSSRKAYEDYKKSSAFRE 136
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLeDPDEYVVLEVWEDEAAFEAHLQSPHFKA 72
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 66-156 3.99e-03

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 34.97  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517994785  66 FHALISIPTTEDHKYQLEKKLESYLPHLDEYEGFNTYRLLKPL-QSNIYKVFLGFSSRKAYEDYKKSSAFREHFSKEavR 144
Cdd:COG2329    2 IVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLeDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKG--R 79

                         90
                 ....*....|..
gi 517994785 145 PLAGSSSAHASY 156
Cdd:COG2329   80 EILAGPPRVEHY 91
 
Name Accession Description Interval E-value
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 66-136 3.70e-03

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 34.55  E-value: 3.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517994785   66 FHALISIPTTEDHKYQLEKKLESYLPHLDEYEGFNTYRLLKPL-QSNIYKVFLGFSSRKAYEDYKKSSAFRE 136
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLeDPDEYVVLEVWEDEAAFEAHLQSPHFKA 72
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 66-156 3.99e-03

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 34.97  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517994785  66 FHALISIPTTEDHKYQLEKKLESYLPHLDEYEGFNTYRLLKPL-QSNIYKVFLGFSSRKAYEDYKKSSAFREHFSKEavR 144
Cdd:COG2329    2 IVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLeDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKG--R 79

                         90
                 ....*....|..
gi 517994785 145 PLAGSSSAHASY 156
Cdd:COG2329   80 EILAGPPRVEHY 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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