NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|518125582|ref|WP_019295790|]
View 

MULTISPECIES: Hint domain-containing protein [unclassified Leisingera]

Protein Classification

Hint domain-containing protein( domain architecture ID 321058)

Hint (Hedgehog/INTein) domain-containing protein

CATH:  2.170.16.10
Gene Ontology:  GO:0016540|GO:0016539
PubMed:  19040769|9489693

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Hint super family cl22434
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
 31-144 2.80e-19

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


The actual alignment was detected with superfamily member pfam13403:

Pssm-ID: 451395 [Multi-domain]  Cd Length: 147  Bit Score: 80.75  E-value: 2.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518125582   31 FLAGTHVASNLGWRPVEALTPGDKVLTFDHGMQTVVELQREVMIPAEGDLEPARCPLFVPRDALMNRVP---MWLMPDQG 107
Cdd:pfam13403   3 FAPGTLIATPRGEVPVETLRPGDLVVTRDGGAQPVRWIGRRTLSLADLPAPPALRPVRIRAGALGPGVPardLLVSPQHR 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 518125582  108 VLLESELVEDSQGDPFAIVPACTLEGYRGIRRMHPGA 144
Cdd:pfam13403  83 LLLDGWRAELLFGEPEVLVPAKHLVNGDSIRDEPARP 119
 
Name Accession Description Interval E-value
Hint_2 pfam13403
Hint domain; This domain is found in inteins.
 31-144 2.80e-19

Hint domain; This domain is found in inteins.


Pssm-ID: 433179 [Multi-domain]  Cd Length: 147  Bit Score: 80.75  E-value: 2.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518125582   31 FLAGTHVASNLGWRPVEALTPGDKVLTFDHGMQTVVELQREVMIPAEGDLEPARCPLFVPRDALMNRVP---MWLMPDQG 107
Cdd:pfam13403   3 FAPGTLIATPRGEVPVETLRPGDLVVTRDGGAQPVRWIGRRTLSLADLPAPPALRPVRIRAGALGPGVPardLLVSPQHR 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 518125582  108 VLLESELVEDSQGDPFAIVPACTLEGYRGIRRMHPGA 144
Cdd:pfam13403  83 LLLDGWRAELLFGEPEVLVPAKHLVNGDSIRDEPARP 119
 
Name Accession Description Interval E-value
Hint_2 pfam13403
Hint domain; This domain is found in inteins.
 31-144 2.80e-19

Hint domain; This domain is found in inteins.


Pssm-ID: 433179 [Multi-domain]  Cd Length: 147  Bit Score: 80.75  E-value: 2.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518125582   31 FLAGTHVASNLGWRPVEALTPGDKVLTFDHGMQTVVELQREVMIPAEGDLEPARCPLFVPRDALMNRVP---MWLMPDQG 107
Cdd:pfam13403   3 FAPGTLIATPRGEVPVETLRPGDLVVTRDGGAQPVRWIGRRTLSLADLPAPPALRPVRIRAGALGPGVPardLLVSPQHR 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 518125582  108 VLLESELVEDSQGDPFAIVPACTLEGYRGIRRMHPGA 144
Cdd:pfam13403  83 LLLDGWRAELLFGEPEVLVPAKHLVNGDSIRDEPARP 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH