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Conserved domains on  [gi|518125621|ref|WP_019295829|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [unclassified Leisingera]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
22-107 4.22e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 93.03  E-value: 4.22e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518125621  22 AAKASNFLKAISHQGRLMILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADDKPRRVLE 101
Cdd:COG0640    7 LEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                 ....*.
gi 518125621 102 VVYDIF 107
Cdd:COG0640   87 WLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
22-107 4.22e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 93.03  E-value: 4.22e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518125621  22 AAKASNFLKAISHQGRLMILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADDKPRRVLE 101
Cdd:COG0640    7 LEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                 ....*.
gi 518125621 102 VVYDIF 107
Cdd:COG0640   87 WLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 25-100 4.46e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 87.13  E-value: 4.46e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518125621  25 ASNFLKAISHQGRLMILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADDKPRRVL 100
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
40-103 7.28e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 68.78  E-value: 7.28e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518125621    40 ILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADDKPRRVLEVV 103
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 29-95 8.46e-16

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 66.17  E-value: 8.46e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518125621  29 LKAISHQGRLMILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADDK 95
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAE 67
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 34-78 1.09e-06

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 42.05  E-value: 1.09e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 518125621   34 HQGRLMILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLV 78
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 30-96 2.72e-05

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 40.18  E-value: 2.72e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518125621  30 KAISHQGRLMILCHL-VSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADDKP 96
Cdd:PRK10141  11 KILSDETRLGIVLLLrESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIP 78
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
22-107 4.22e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 93.03  E-value: 4.22e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518125621  22 AAKASNFLKAISHQGRLMILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADDKPRRVLE 101
Cdd:COG0640    7 LEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                 ....*.
gi 518125621 102 VVYDIF 107
Cdd:COG0640   87 WLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 25-100 4.46e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 87.13  E-value: 4.46e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518125621  25 ASNFLKAISHQGRLMILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADDKPRRVL 100
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
40-103 7.28e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 68.78  E-value: 7.28e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518125621    40 ILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADDKPRRVLEVV 103
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 29-95 8.46e-16

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 66.17  E-value: 8.46e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518125621  29 LKAISHQGRLMILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADDK 95
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAE 67
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 34-78 1.09e-06

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 42.05  E-value: 1.09e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 518125621   34 HQGRLMILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLV 78
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 30-96 2.72e-05

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 40.18  E-value: 2.72e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518125621  30 KAISHQGRLMILCHL-VSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADDKP 96
Cdd:PRK10141  11 KILSDETRLGIVLLLrESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIP 78
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
40-94 4.38e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.55  E-value: 4.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 518125621  40 ILCHLV-SGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLADD 94
Cdd:COG3398  102 ILLYLLeNPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
PaaX pfam07848
PaaX-like protein; This family contains proteins that are similar to the product of the paaX ...
 47-93 2.98e-03

PaaX-like protein; This family contains proteins that are similar to the product of the paaX gene of Escherichia coli. This protein is involved in the regulation of expression of a group of proteins known to participate in the metabolism of phenylacetic acid. In fact, some members of this family are annotated by InterPro as containing a winged helix DNA-binding domain (Interpro:IPR009058).


Pssm-ID: 285132 [Multi-domain]  Cd Length: 70  Bit Score: 33.86  E-value: 2.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 518125621   47 GEKSVTELEQLLSA---RQAAVSQQLSRLRLEGLVVPRRDGKAIYYSLAD 93
Cdd:pfam07848  19 GAIWLGSLIRLLAGfgiSERTVRTALSRLVKAGWLVRERTGRRSYYRLSD 68
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
18-91 6.57e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 34.48  E-value: 6.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518125621  18 MVANAAKASNFLKAISHqgRLMILCHLVSGEKSVTELEQLLSARQAAVSQQLSRLRLEGLVVpRRDGKaiyYSL 91
Cdd:COG4742    1 MGSMKLDLLDFLFLSEK--RKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIE-RDDGE---YEL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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