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Conserved domains on  [gi|518160760|ref|WP_019330968|]
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MULTISPECIES: DUF4439 domain-containing protein [Streptomyces]

Protein Classification

ferritin family protein( domain architecture ID 38)

ferritin family protein similar to rubrerythrin, a non-heme di-iron that is involved in oxidative stress defense as a peroxide scavenger in a wide range of organisms

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ferritin_like super family cl00264
Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Ferritin-like, ...
 24-141 1.13e-15

Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Ferritin-like, diiron-carboxylate proteins participate in a range of functions including iron regulation, mono-oxygenation, and reactive radical production. These proteins are characterized by the fact that they catalyze dioxygen-dependent oxidation-hydroxylation reactions within diiron centers; one exception is manganese catalase, which catalyzes peroxide-dependent oxidation-reduction within a dimanganese center. Diiron-carboxylate proteins are further characterized by the presence of duplicate metal ligands, glutamates and histidines (ExxH) and two additional glutamates within a four-helix bundle. Outside of these conserved residues there is little obvious homology. Members include bacterioferritin, ferritin, rubrerythrin, aromatic and alkene monooxygenase hydroxylases (AAMH), ribonucleotide reductase R2 (RNRR2), acyl-ACP-desaturases (Acyl_ACP_Desat), manganese (Mn) catalases, demethoxyubiquinone hydroxylases (DMQH), DNA protecting proteins (DPS), and ubiquinol oxidases (AOX), and the aerobic cyclase system, Fe-containing subunit (ACSF).


The actual alignment was detected with superfamily member pfam14530:

Pssm-ID: 469698  Cd Length: 132  Bit Score: 68.92  E-value: 1.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518160760   24 YGYGVVGGRVGEERRTEARAAYDAHRARRDALTRDVRDLGARPVASAAGYALPFEVPDAASAVRLAAELEERVAGVYSDL 103
Cdd:pfam14530  14 YGYGVVGARLDGARRDAARDALAAHRARRDALIALLVARGATPPPAAAGYTLPFEVTDAASAARLAAALEEDLAAAYRAL 93

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 518160760  104 VRAVGGDRRTAAAGALREAAVRAARWRG-GSVAFPGLAE 141
Cdd:pfam14530  94 VAADDADLRTTAATALTEAAVRAARWRAeAGVAFPGMPE 132
 
Name Accession Description Interval E-value
DUF4439 pfam14530
Domain of unknown function (DUF4439); This domain has a ferritin-like fold.
 24-141 1.13e-15

Domain of unknown function (DUF4439); This domain has a ferritin-like fold.


Pssm-ID: 434020  Cd Length: 132  Bit Score: 68.92  E-value: 1.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518160760   24 YGYGVVGGRVGEERRTEARAAYDAHRARRDALTRDVRDLGARPVASAAGYALPFEVPDAASAVRLAAELEERVAGVYSDL 103
Cdd:pfam14530  14 YGYGVVGARLDGARRDAARDALAAHRARRDALIALLVARGATPPPAAAGYTLPFEVTDAASAARLAAALEEDLAAAYRAL 93

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 518160760  104 VRAVGGDRRTAAAGALREAAVRAARWRG-GSVAFPGLAE 141
Cdd:pfam14530  94 VAADDADLRTTAATALTEAAVRAARWRAeAGVAFPGMPE 132
 
Name Accession Description Interval E-value
DUF4439 pfam14530
Domain of unknown function (DUF4439); This domain has a ferritin-like fold.
 24-141 1.13e-15

Domain of unknown function (DUF4439); This domain has a ferritin-like fold.


Pssm-ID: 434020  Cd Length: 132  Bit Score: 68.92  E-value: 1.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518160760   24 YGYGVVGGRVGEERRTEARAAYDAHRARRDALTRDVRDLGARPVASAAGYALPFEVPDAASAVRLAAELEERVAGVYSDL 103
Cdd:pfam14530  14 YGYGVVGARLDGARRDAARDALAAHRARRDALIALLVARGATPPPAAAGYTLPFEVTDAASAARLAAALEEDLAAAYRAL 93

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 518160760  104 VRAVGGDRRTAAAGALREAAVRAARWRG-GSVAFPGLAE 141
Cdd:pfam14530  94 VAADDADLRTTAATALTEAAVRAARWRAeAGVAFPGMPE 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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